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TDMS Study 05197-12 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/18/98

EXPERIMENT: 05197 TEST: 12                                                                                     TIME: 09:23:05
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 111-76-0002
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/18/98     
EXPERIMENT: 05197 TEST: 12                                                                                     TIME: 09:23:05     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D     
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 111-76-0002   



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 2-BUTOXYETHANOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
                                       Hypertrophy
Bone Marrow                            Hyperplasia
Heart                                  Cardiomyopathy
Islets, Pancreatic                     Hyperplasia
Kidney                                 Glomerulosclerosis
                                       Hydronephrosis
                                       Inflammation Chronic
                                       Nephropathy
Kidney: Renal Tubule                   Pigmentation
Liver                                  Basophilic Focus
                                       Necrosis
Liver: Kupffer Cell                    Pigmentation Hemosiderin
Lung                                   Infiltration Cellular Histiocyte
Lung: Alveolar Epithelium              Hyperplasia
Nose: Olfactory Epithelium             Atrophy
Pancreas                               Atrophy
Preputial Gland                        Inflammation
Prostate                               Inflammation
Skin: Prepuce                          Hyperplasia
                                       Inflammation Chronic
                                       Ulcer
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
                                       Pigmentation Hemosiderin
Stomach, Forestomach                   Ulcer
Stomach, Forestomach: Epithelium       Hyperplasia
Stomach, Glandular: Epithelium         Hyperplasia
Urinary Bladder                        Inflammation
Urinary Bladder: Transitional Epithelium
                                       Ulcer
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Degeneration Cystic
Kidney                                 Glomerulosclerosis
Larynx: Squamous Epithelium            Hyperplasia
Liver                                  Hematopoietic Cell Proliferation
                                       Necrosis
Liver: Kupffer Cell                    Pigmentation Hemosiderin
Lung                                   Hemorrhage
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/18/98     
EXPERIMENT: 05197 TEST: 12                                                                                     TIME: 09:23:05     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D     
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 111-76-0002   

Lymph Node, Bronchial                  Hyperplasia
Nose: Olfactory Epithelium             Degeneration Hyaline
Nose: Respiratory Epithelium           Degeneration Hyaline
Ovary                                  Cyst
Spleen                                 Hematopoietic Cell Proliferation
                                       Hyperplasia Lymphoid
                                       Pigmentation Hemosiderin
Stomach, Forestomach                   Ulcer
Stomach, Forestomach: Epithelium       Hyperplasia
Uterus                                 Hyperplasia Cystic
===============================================================
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.5%         |
|TERMINAL (d)       |     1/39 (3%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    2/36 (6%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.362N     P=0.500N     P=0.573N     P=0.581N    |P=0.061      (e)          (e)          P=0.287      |
|POLY 3             |     P=0.305N     P=0.490N     P=0.525N     P=0.526N    |P=0.047 *    (e)          (e)          P=0.242      |
|POLY 1.5           |     P=0.304N     P=0.494N     P=0.515N     P=0.518N    |P=0.046 *    (e)          (e)          P=0.240      |
|POLY 6             |     P=0.306N     P=0.488N     P=0.538N     P=0.536N    |P=0.047 *    (e)          (e)          P=0.246      |
|LOGISTIC REGRESSION|     P=0.362N     (e)          (e)          (e)         |(e)          (e)          (e)          P=0.287      |
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.505N     P=0.500N    |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         2.5%         0.0%        |2.3%         4.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     663          ---          600          ---         |645          456          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.440N     P=0.486N     P=0.711      P=0.531N    |P=0.189N     P=0.491      P=0.500N     P=0.485N     |
|POLY 3             |     P=0.435N     P=0.491N     P=0.734      P=0.527N    |P=0.188N     P=0.500      P=0.506N     P=0.497N     |
|POLY 1.5           |     P=0.425N     P=0.494N     P=0.744      P=0.518N    |P=0.189N     P=0.497      P=0.507N     P=0.498N     |
|POLY 6             |     P=0.445N     P=0.490N     P=0.718      P=0.538N    |P=0.185N     P=0.506      P=0.502N     P=0.494N     |
|LOGISTIC REGRESSION|     P=0.333N     P=0.550N     P=0.735N     P=0.492N    |P=0.171N     P=0.647      P=0.486N     P=0.508N     |
|COCH-ARM / FISHERS |     P=0.406N     P=0.500N     P=0.747      P=0.500N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   9/50 (18%)   9/49 (18%)   9/50 (18%)  |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     11.1%        18.8%        22.0%        22.8%       |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     5/39 (13%)   7/39 (18%)   7/27 (26%)   9/26 (35%)  |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      549          502          729 (T)     |715          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.035 *    P=0.199      P=0.063      P=0.038 *   |P=0.296N     P=0.506N     P=0.483N     P=0.489N     |
|POLY 3             |     P=0.114      P=0.229      P=0.140      P=0.125     |P=0.307N     P=0.505N     P=0.505N     P=0.496N     |
|POLY 1.5           |     P=0.144      P=0.216      P=0.159      P=0.145     |P=0.306N     P=0.505N     P=0.507N     P=0.498N     |
|POLY 6             |     P=0.084      P=0.240      P=0.116      P=0.103     |P=0.308N     P=0.503N     P=0.500N     P=0.492N     |
|LOGISTIC REGRESSION|     P=0.105      P=0.216      P=0.133      P=0.038 *   |P=0.302N     P=0.503N     P=0.501N     P=0.493N     |
|COCH-ARM / FISHERS |     P=0.216      P=0.194      P=0.183      P=0.194     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     38/50 (76%)  28/50 (56%)  27/49 (55%)  27/50 (54%) |3/50 (6%)    2/50 (4%)    6/50 (12%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     81.7%        58.7%        64.2%        62.9%       |7.0%         4.8%         14.2%        11.4%        |
|TERMINAL (d)       |     34/39 (87%)  26/39 (67%)  21/27 (78%)  19/26 (73%) |2/29 (7%)    1/31 (3%)    4/33 (12%)   5/36 (14%)   |
|FIRST INCIDENCE    |     556          649          430          374         |721          712          627          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.271      P=0.019N*    P=0.575N     P=0.551     |P=0.280      P=0.482N     P=0.307      P=0.472      |
|POLY 3             |     P=0.078N     P=0.009N**   P=0.038N*    P=0.030N*   |P=0.204      P=0.511N     P=0.233      P=0.368      |
|POLY 1.5           |     P=0.060N     P=0.014N*    P=0.027N*    P=0.026N*   |P=0.199      P=0.511N     P=0.228      P=0.363      |
|POLY 6             |     P=0.107N     P=0.007N**   P=0.075N     P=0.038N*   |P=0.211      P=0.506N     P=0.248      P=0.377      |
|LOGISTIC REGRESSION|     P=0.182N     P=0.006N**   P=0.101N     P=0.070N    |P=0.213      P=0.500N     P=0.239      P=0.407      |
|COCH-ARM / FISHERS |     P=0.033N*    P=0.028N*    P=0.024N*    P=0.018N*   |P=0.189      P=0.500N     P=0.243      P=0.357      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Capsule                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         0.0%         7.6%        |0.0%         0.0%         2.4%         0.0%         |
|TERMINAL (d)       |     2/39 (5%)    0/39 (0%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    0/31 (0%)    1/33 (3%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          663         |---          ---          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.146      P=0.238N     P=0.322N     P=0.342     |P=0.719      (e)          P=0.526      (e)          |
|POLY 3             |     P=0.217      P=0.227N     P=0.266N     P=0.444     |P=0.708      (e)          P=0.495      (e)          |
|POLY 1.5           |     P=0.226      P=0.230N     P=0.255N     P=0.461     |P=0.703      (e)          P=0.494      (e)          |
|POLY 6             |     P=0.206      P=0.224N     P=0.282N     P=0.424     |P=0.713      (e)          P=0.500      (e)          |
|LOGISTIC REGRESSION|     P=0.183      (e)          (e)          P=0.416     |(e)          (e)          P=0.526      (e)          |
|COCH-ARM / FISHERS |     P=0.245      P=0.247N     P=0.253N     P=0.500     |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/49 (0%)    3/49 (6%)   |1/50 (2%)    3/50 (6%)    3/49 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         0.0%         7.8%        |2.3%         7.2%         7.3%         4.5%         |
|TERMINAL (d)       |     0/38 (0%)    1/39 (3%)    0/27 (0%)    2/25 (8%)   |1/29 (3%)    3/31 (10%)   3/33 (9%)    2/36 (6%)    |
|FIRST INCIDENCE    |     565          681          ---          684         |731 (T)      731 (T)      731 (T)      731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.152      P=0.524      P=0.513N     P=0.216     |P=0.574      P=0.328      P=0.352      P=0.576      |
|POLY 3             |     P=0.200      P=0.522      P=0.523N     P=0.257     |P=0.493      P=0.296      P=0.290      P=0.508      |
|POLY 1.5           |     P=0.214      P=0.517      P=0.513N     P=0.272     |P=0.486      P=0.296      P=0.287      P=0.504      |
|POLY 6             |     P=0.184      P=0.525      P=0.537N     P=0.239     |P=0.504      P=0.299      P=0.300      P=0.514      |
|LOGISTIC REGRESSION|     P=0.226      P=0.409      P=0.463N     P=0.296     |P=0.574      P=0.328      P=0.352      P=0.576      |
|COCH-ARM / FISHERS |     P=0.239      P=0.508      P=0.500N     P=0.309     |P=0.476      P=0.309      P=0.301      P=0.500      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    0/50 (0%)    1/50 (2%)   |22/50 (44%)  28/50 (56%)  25/50 (50%)  21/50 (42%)  |
|POLY-3 ADJUSTED (b)|     2.2%         8.5%         0.0%         2.5%        |50.5%        64.4%        58.9%        46.1%        |
|TERMINAL (d)       |     1/39 (3%)    4/39 (10%)   0/27 (0%)    0/26 (0%)   |17/29 (59%)  22/31 (71%)  22/33 (67%)  17/36 (47%)  |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          694         |649          592          627          485          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.489N     P=0.179      P=0.573N     P=0.685     |P=0.074N     P=0.235      P=0.570      P=0.207N     |
|POLY 3             |     P=0.382N     P=0.194      P=0.524N     P=0.732     |P=0.212N     P=0.127      P=0.279      P=0.417N     |
|POLY 1.5           |     P=0.364N     P=0.189      P=0.513N     P=0.741     |P=0.253N     P=0.126      P=0.275      P=0.454N     |
|POLY 6             |     P=0.407N     P=0.197      P=0.538N     P=0.721     |P=0.166N     P=0.151      P=0.313      P=0.363N     |
|LOGISTIC REGRESSION|     P=0.443N     P=0.179      (e)          P=0.729     |P=0.226N     P=0.121      P=0.380      P=0.434N     |
|COCH-ARM / FISHERS |     P=0.337N     P=0.181      P=0.500N     P=0.753N    |P=0.316N     P=0.159      P=0.344      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    9/49 (18%)   5/50 (10%)  |2/50 (4%)    4/50 (8%)    2/50 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         21.2%        12.5%       |4.6%         9.1%         4.6%         9.0%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    2/27 (7%)    3/26 (12%)  |1/29 (3%)    0/31 (0%)    0/33 (0%)    2/36 (6%)    |
|FIRST INCIDENCE    |     ---          729 (T)      537          670         |715          255          72           582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005 **   P=0.500      P<0.001 **   P=0.015 *   |P=0.386      P=0.347      P=0.680N     P=0.402      |
|POLY 3             |     P=0.005 **   P=0.510      P<0.001 **   P=0.021 *   |P=0.359      P=0.348      P=0.690N     P=0.353      |
|POLY 1.5           |     P=0.007 **   P=0.506      P<0.001 **   P=0.024 *   |P=0.352      P=0.341      P=0.693      P=0.346      |
|POLY 6             |     P=0.004 **   P=0.512      P<0.001 **   P=0.019 *   |P=0.371      P=0.361      P=0.679N     P=0.365      |
|LOGISTIC REGRESSION|     P=0.021 *    P=0.500      P=0.004 **   P=0.022 *   |P=0.302      P=0.460      P=0.525N     P=0.341      |
|COCH-ARM / FISHERS |     P=0.017 *    P=0.500      P<0.001 **   P=0.028 *   |P=0.344      P=0.339      P=0.691N     P=0.339      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Meninges                                                                                                                  |
|     Infiltration Cellular Mononuclear Cell                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         0.0%         0.0%        |4.6%         0.0%         0.0%         4.5%         |
|TERMINAL (d)       |     1/39 (3%)    1/39 (3%)    0/27 (0%)    0/26 (0%)   |1/29 (3%)    0/31 (0%)    0/33 (0%)    2/36 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |689          ---          ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.308N     P=0.762      P=0.573N     P=0.581N    |P=0.548      P=0.235N     P=0.223N     P=0.635N     |
|POLY 3             |     P=0.251N     P=0.750N     P=0.525N     P=0.526N    |P=0.508      P=0.244N     P=0.243N     P=0.687N     |
|POLY 1.5           |     P=0.245N     P=0.753N     P=0.515N     P=0.518N    |P=0.505      P=0.243N     P=0.245N     P=0.690N     |
|POLY 6             |     P=0.260N     P=0.747N     P=0.538N     P=0.536N    |P=0.510      P=0.242N     P=0.238N     P=0.682N     |
|LOGISTIC REGRESSION|     P=0.308N     P=0.762      (e)          (e)         |P=0.516      P=0.242N     P=0.241N     P=0.679N     |
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.505N     P=0.500N    |P=0.500      P=0.247N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    1/49 (2%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     8.9%         8.5%         2.5%         10.1%       |                                                    |
|TERMINAL (d)       |     4/39 (10%)   4/39 (10%)   1/27 (4%)    4/26 (15%)  |                                                    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.384      P=0.645      P=0.304N     P=0.409     |                                                    |
|POLY 3             |     P=0.557      P=0.616N     P=0.218N     P=0.570     |                                                    |
|POLY 1.5           |     P=0.564N     P=0.625N     P=0.203N     P=0.594     |                                                    |
|POLY 6             |     P=0.524      P=0.610N     P=0.242N     P=0.541     |                                                    |
|LOGISTIC REGRESSION|     P=0.384      P=0.645      P=0.304N     P=0.409     |                                                    |
|COCH-ARM / FISHERS |     P=0.521N     P=0.643N     P=0.187N     P=0.643N    |                                                    |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)    |1/1 (100%)   0/0 (0%)     0/0 (0%)     3/4 (75%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         100.0%       0.0%        |100.0%       0.0%         0.0%         75.0%        |
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     1/1 (100%)   0/0 (0%)    |1/1 (100%)   0/0 (0%)     0/0 (0%)     1/2 (50%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |731 (T)      ---          ---          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.500      (e)          P=0.500      (e)         |P=0.256      (e)          (e)          P=0.485      |
|POLY 3             |     P=1.000N     (e)          P=1.000N     (e)         |P=1.000      (e)          (e)          P=0.749N     |
|POLY 1.5           |     P=1.000N     (e)          P=1.000N     (e)         |P=1.000      (e)          (e)          P=0.749N     |
|POLY 6             |     P=1.000N     (e)          P=1.000N     (e)         |P=1.000      (e)          (e)          P=0.749N     |
|LOGISTIC REGRESSION|     P=0.250      (e)          P=0.250      (e)         |P=0.256      (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500      (e)          P=0.500      (e)         |P=0.556N     (e)          (e)          P=0.800N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     47/50 (94%)  48/50 (96%)  47/50 (94%)  47/50 (94%) |46/50 (92%)  45/50 (90%)  44/50 (88%)  45/50 (90%)  |
|POLY-3 ADJUSTED (b)|     97.4%        97.3%        98.0%        99.2%       |94.7%        96.3%        94.4%        94.9%        |
|TERMINAL (d)       |     39/39 (100%) 39/39 (100%) 27/27 (100%) 26/26 (100%)|29/29 (100%) 30/31 (97%)  32/33 (97%)  36/36 (100%) |
|FIRST INCIDENCE    |     459          611          430          312         |521          456          72           485          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.567      P=0.006 **   P=0.004 **  |P=0.057N     P=0.384N     P=0.180N     P=0.069N     |
|POLY 3             |     P=0.309      P=0.774N     P=0.751      P=0.557     |P=0.564N     P=0.553      P=0.668N     P=0.690      |
|POLY 1.5           |     P=0.369      P=0.671      P=0.704      P=0.515     |P=0.467N     P=0.621      P=0.572N     P=0.603N     |
|POLY 6             |     P=0.331      P=0.776N     P=0.880      P=0.781     |P=0.482      P=0.531      P=0.674      P=0.562      |
|LOGISTIC REGRESSION|     P=0.043 *    P=0.477N     P=0.381      P=0.150     |P=0.346N     P=0.523      P=0.604N     P=0.479N     |
|COCH-ARM / FISHERS |     P=0.521N     P=0.500      P=0.661N     P=0.661N    |P=0.437N     P=0.500N     P=0.370N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum                                                                                                        |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/44 (0%)    1/41 (2%)   |0/45 (0%)    2/49 (4%)    0/47 (0%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.8%        |0.0%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/25 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          684         |---          472          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170      (e)          (e)          P=0.461     |P=0.402N     P=0.235      (e)          (e)          |
|POLY 3             |     P=0.168      (e)          (e)          P=0.455     |P=0.398N     P=0.252      (e)          (e)          |
|POLY 1.5           |     P=0.170      (e)          (e)          P=0.457     |P=0.400N     P=0.252      (e)          (e)          |
|POLY 6             |     P=0.166      (e)          (e)          P=0.451     |P=0.392N     P=0.254      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.178      (e)          (e)          P=0.466     |P=0.419N     P=0.357      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.176      (e)          (e)          P=0.456     |P=0.400N     P=0.269      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Duodenum: Epithelium                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/44 (0%)    1/41 (2%)   |1/45 (2%)    2/49 (4%)    0/47 (0%)    2/47 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.8%        |2.5%         4.8%         0.0%         4.6%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/25 (0%)   |1/29 (3%)    1/31 (3%)    0/33 (0%)    1/36 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          684         |731 (T)      472          ---          485          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170      (e)          (e)          P=0.461     |P=0.513      P=0.508      P=0.474N     P=0.548      |
|POLY 3             |     P=0.168      (e)          (e)          P=0.455     |P=0.492      P=0.519      P=0.493N     P=0.533      |
|POLY 1.5           |     P=0.170      (e)          (e)          P=0.457     |P=0.485      P=0.521      P=0.494N     P=0.526      |
|POLY 6             |     P=0.166      (e)          (e)          P=0.451     |P=0.500      P=0.521      P=0.488N     P=0.541      |
|LOGISTIC REGRESSION|     P=0.178      (e)          (e)          P=0.466     |P=0.450      P=0.564      (e)          P=0.483      |
|COCH-ARM / FISHERS |     P=0.176      (e)          (e)          P=0.456     |P=0.476      P=0.532      P=0.489N     P=0.516      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    2/47 (4%)    0/46 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     13.2%        6.3%         5.1%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     5/39 (13%)   2/39 (5%)    2/27 (7%)    0/25 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     561          707          729 (T)      ---         |586          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.031N*    P=0.242N     P=0.263N     P=0.049N*   |P=0.308N     P=0.505N     P=0.514N     P=0.500N     |
|POLY 3             |     P=0.017N*    P=0.223N     P=0.187N     P=0.029N*   |P=0.305N     P=0.507N     P=0.507N     P=0.498N     |
|POLY 1.5           |     P=0.015N*    P=0.230N     P=0.171N     P=0.026N*   |P=0.305N     P=0.506N     P=0.508N     P=0.499N     |
|POLY 6             |     P=0.020N*    P=0.220N     P=0.213N     P=0.033N*   |P=0.305N     P=0.507N     P=0.503N     P=0.495N     |
|LOGISTIC REGRESSION|     P=0.017N*    P=0.234N     P=0.184N     P=0.027N*   |P=0.303N     P=0.446N     P=0.459N     P=0.518N     |
|COCH-ARM / FISHERS |     P=0.012N*    P=0.243N     P=0.155N     P=0.017N*   |P=0.306N     P=0.500N     P=0.505N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Glomerulosclerosis                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    11/47 (23%)  9/50 (18%)  |7/50 (14%)   2/50 (4%)    8/49 (16%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     8.6%         8.3%         25.7%        21.8%       |15.5%        4.7%         17.7%        16.9%        |
|TERMINAL (d)       |     1/39 (3%)    1/39 (3%)    3/27 (11%)   5/26 (19%)  |2/29 (7%)    0/31 (0%)    1/33 (3%)    2/36 (6%)    |
|FIRST INCIDENCE    |     561          611          430          454         |376          534          408          437          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.018 *    P=0.609N     P=0.026 *    P=0.056     |P=0.288      P=0.095N     P=0.516      P=0.566      |
|POLY 3             |     P=0.020 *    P=0.622N     P=0.028 *    P=0.074     |P=0.268      P=0.091N     P=0.498      P=0.536      |
|POLY 1.5           |     P=0.026 *    P=0.628N     P=0.030 *    P=0.086     |P=0.251      P=0.089N     P=0.482      P=0.520      |
|POLY 6             |     P=0.014 *    P=0.617N     P=0.025 *    P=0.062     |P=0.289      P=0.090N     P=0.524      P=0.559      |
|LOGISTIC REGRESSION|     P=0.140      P=0.412      P=0.062      P=0.142     |P=0.167      P=0.041N*    P=0.587      P=0.455      |
|COCH-ARM / FISHERS |     P=0.049 *    P=0.643N     P=0.034 *    P=0.117     |P=0.223      P=0.080N     P=0.483      P=0.500      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    6/47 (13%)   5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         14.6%        12.4%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    1/27 (4%)    1/26 (4%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     565          ---          537          596         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.012 *    P=0.487N     P=0.045 *    P=0.072     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.011 *    P=0.493N     P=0.041 *    P=0.076     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.013 *    P=0.495N     P=0.044 *    P=0.083     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.009 **   P=0.492N     P=0.037 *    P=0.070     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.052      P=0.707N     P=0.066      P=0.111     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.022 *    P=0.500N     P=0.047 *    P=0.102     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/47 (4%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         5.0%         10.0%       |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          707          563          623         |---          534          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.010 *    P=0.505      P=0.211      P=0.034 *   |P=0.571N     P=0.487      (e)          (e)          |
|POLY 3             |     P=0.014 *    P=0.510      P=0.211      P=0.047 *   |P=0.568N     P=0.498      (e)          (e)          |
|POLY 1.5           |     P=0.016 *    P=0.507      P=0.217      P=0.050     |P=0.569N     P=0.497      (e)          (e)          |
|POLY 6             |     P=0.013 *    P=0.513      P=0.202      P=0.042 *   |P=0.564N     P=0.501      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.026 *    P=0.502      P=0.246      P=0.051     |P=0.586N     P=0.597      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.022 *    P=0.500      P=0.232      P=0.059     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/47 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    3/49 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         0.0%         0.0%        |2.3%         2.4%         7.1%         9.1%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    0/27 (0%)    0/26 (0%)   |1/29 (3%)    1/31 (3%)    3/33 (9%)    4/36 (11%)   |
|FIRST INCIDENCE    |     ---          649          ---          ---         |731 (T)      731 (T)      731 (T)      731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.474N     P=0.252      (e)          (e)         |P=0.116      P=0.747N     P=0.352      P=0.249      |
|POLY 3             |     P=0.430N     P=0.250      (e)          (e)         |P=0.081      P=0.755      P=0.296      P=0.185      |
|POLY 1.5           |     P=0.421N     P=0.245      (e)          (e)         |P=0.079      P=0.755      P=0.292      P=0.182      |
|POLY 6             |     P=0.445N     P=0.253      (e)          (e)         |P=0.083      P=0.758      P=0.305      P=0.190      |
|LOGISTIC REGRESSION|     P=0.411N     P=0.213      (e)          (e)         |P=0.116      P=0.747N     P=0.352      P=0.249      |
|COCH-ARM / FISHERS |     P=0.407N     P=0.247      (e)          (e)         |P=0.075      P=0.753N     P=0.301      P=0.181      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/47 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         5.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/39 (3%)    0/39 (0%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.155      P=0.500N     P=0.573N     P=0.360     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.222      P=0.490N     P=0.529N     P=0.455     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.230      P=0.494N     P=0.521N     P=0.469     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.214      P=0.488N     P=0.540N     P=0.437     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.155      (e)          (e)          P=0.360     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.515N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  45/50 (90%)  40/47 (85%)  37/50 (74%) |34/50 (68%)  39/50 (78%)  38/49 (78%)  33/50 (66%)  |
|POLY-3 ADJUSTED (b)|     96.7%        92.7%        91.5%        85.6%       |72.3%        84.0%        84.7%        70.9%        |
|TERMINAL (d)       |     38/39 (97%)  38/39 (97%)  27/27 (100%) 24/26 (92%) |21/29 (72%)  26/31 (84%)  31/33 (94%)  26/36 (72%)  |
|FIRST INCIDENCE    |     374          649          430          374         |521          456          456          582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.139      P=0.272N     P=0.176      P=0.333     |P=0.066N     P=0.328      P=0.528      P=0.163N     |
|POLY 3             |     P=0.020N*    P=0.311N     P=0.223N     P=0.037N*   |P=0.352N     P=0.122      P=0.106      P=0.532N     |
|POLY 1.5           |     P=0.007N**   P=0.262N     P=0.125N     P=0.013N*   |P=0.343N     P=0.129      P=0.121      P=0.521N     |
|POLY 6             |     P=0.055N     P=0.403N     P=0.477N     P=0.098N    |P=0.359N     P=0.131      P=0.096      P=0.535N     |
|LOGISTIC REGRESSION|     P=0.023N*    P=0.100N     P=0.097N     P=0.015N*   |P=0.278N     P=0.125      P=0.145      P=0.465N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.218N     P=0.066N     P=0.002N**  |P=0.342N     P=0.184      P=0.200      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Cortex                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    0/47 (0%)    6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.9%         2.1%         0.0%         15.1%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/39 (10%)   1/39 (3%)    0/27 (0%)    4/26 (15%)  |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          694         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.056      P=0.179N     P=0.118N     P=0.165     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.126      P=0.164N     P=0.080N     P=0.294     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.136      P=0.169N     P=0.075N     P=0.317     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.115      P=0.161N     P=0.090N     P=0.268     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.075      P=0.179N     (e)          P=0.221     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.159      P=0.181N     P=0.066N     P=0.370     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/47 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         4.2%         2.6%         0.0%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     2/39 (5%)    2/39 (5%)    1/27 (4%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          606          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.211N     P=0.695      P=0.628N     P=0.331N    |P=0.559N     P=0.495      (e)          (e)          |
|POLY 3             |     P=0.156N     P=0.676N     P=0.551N     P=0.267N    |P=0.568N     P=0.497      (e)          (e)          |
|POLY 1.5           |     P=0.146N     P=0.682N     P=0.537N     P=0.257N    |P=0.570N     P=0.496      (e)          (e)          |
|POLY 6             |     P=0.168N     P=0.672N     P=0.570N     P=0.279N    |P=0.564N     P=0.501      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.211N     P=0.695      P=0.628N     (e)         |P=0.578N     P=0.539      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.128N     P=0.691N     P=0.523N     P=0.247N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    3/47 (6%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.8%         4.2%         7.7%         5.0%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     3/39 (8%)    2/39 (5%)    1/27 (4%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     556          729 (T)      681          638         |---          712          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.493N     P=0.337N     P=0.644      P=0.468N    |P=0.562N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.390N     P=0.321N     P=0.582N     P=0.398N    |P=0.569N     P=0.495      (e)          (e)          |
|POLY 1.5           |     P=0.369N     P=0.326N     P=0.560N     P=0.379N    |P=0.570N     P=0.495      (e)          (e)          |
|POLY 6             |     P=0.414N     P=0.318N     P=0.611N     P=0.419N    |P=0.565N     P=0.498      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.345N     P=0.346N     P=0.550N     P=0.335N    |P=0.562N     P=0.496      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.323N     P=0.339N     P=0.535N     P=0.339N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/47 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         7.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    1/26 (4%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          613         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.007 **   (e)          (e)          P=0.089     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.009 **   (e)          (e)          P=0.099     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.010 *    (e)          (e)          P=0.105     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.009 **   (e)          (e)          P=0.093     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.012 *    (e)          (e)          P=0.117     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/48 (0%)    1/49 (2%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.6%        |2.3%         6.9%         0.0%         2.3%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          684         |730          534          ---          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.170      (e)          (e)          P=0.461     |P=0.396N     P=0.306      P=0.481N     P=0.743N     |
|POLY 3             |     P=0.179      (e)          (e)          P=0.472     |P=0.409N     P=0.308      P=0.505N     P=0.757N     |
|POLY 1.5           |     P=0.184      (e)          (e)          P=0.479     |P=0.414N     P=0.303      P=0.507N     P=0.761N     |
|POLY 6             |     P=0.174      (e)          (e)          P=0.464     |P=0.401N     P=0.320      P=0.500N     P=0.752N     |
|LOGISTIC REGRESSION|     P=0.190      (e)          (e)          P=0.489     |P=0.422N     P=0.358      P=0.483N     P=0.749      |
|COCH-ARM / FISHERS |     P=0.196      (e)          (e)          P=0.495     |P=0.416N     P=0.309      P=0.500N     P=0.747      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Squamous Epithelium                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/48 (0%)    0/49 (0%)   |2/50 (4%)    8/50 (16%)   3/50 (6%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     0.0%         6.3%         0.0%         0.0%        |4.6%         17.5%        7.0%         11.2%        |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    0/27 (0%)    0/26 (0%)   |2/29 (7%)    1/31 (3%)    1/33 (3%)    2/35 (6%)    |
|FIRST INCIDENCE    |     ---          670          ---          ---         |731 (T)      255          397          437          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.393N     P=0.137      (e)          (e)         |P=0.460      P=0.058      P=0.546      P=0.273      |
|POLY 3             |     P=0.346N     P=0.129      (e)          (e)         |P=0.427      P=0.055      P=0.498      P=0.232      |
|POLY 1.5           |     P=0.334N     P=0.125      (e)          (e)         |P=0.409      P=0.050      P=0.491      P=0.222      |
|POLY 6             |     P=0.364N     P=0.132      (e)          (e)         |P=0.450      P=0.066      P=0.512      P=0.246      |
|LOGISTIC REGRESSION|     P=0.338N     P=0.113      (e)          (e)         |P=0.357      P=0.076      P=0.513      P=0.193      |
|COCH-ARM / FISHERS |     P=0.318N     P=0.121      (e)          (e)         |P=0.388      P=0.046 *    P=0.500      P=0.210      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |0.0%         2.4%         0.0%         4.5%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    1/27 (4%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    2/36 (6%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          712          ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.638      (e)          P=0.427      (e)         |P=0.166      P=0.500      (e)          P=0.287      |
|POLY 3             |     P=0.640      (e)          P=0.475      (e)         |P=0.143      P=0.495      (e)          P=0.242      |
|POLY 1.5           |     P=0.654      (e)          P=0.485      (e)         |P=0.142      P=0.495      (e)          P=0.240      |
|POLY 6             |     P=0.627      (e)          P=0.462      (e)         |P=0.146      P=0.498      (e)          P=0.246      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.427      (e)         |P=0.150      P=0.496      (e)          P=0.287      |
|COCH-ARM / FISHERS |     P=0.692      (e)          P=0.495      (e)         |P=0.140      P=0.500      (e)          P=0.247      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    3/49 (6%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         7.5%        |2.3%         0.0%         0.0%         2.3%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |1/29 (3%)    0/31 (0%)    0/33 (0%)    1/36 (3%)    |
|FIRST INCIDENCE    |     ---          ---          618          442         |731 (T)      ---          ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.014 *    (e)          P=0.455      P=0.099     |P=0.637      P=0.487N     P=0.474N     P=0.713N     |
|POLY 3             |     P=0.015 *    (e)          P=0.477      P=0.100     |P=0.601      P=0.505N     P=0.505N     P=0.756N     |
|POLY 1.5           |     P=0.016 *    (e)          P=0.486      P=0.104     |P=0.599      P=0.505N     P=0.507N     P=0.758N     |
|POLY 6             |     P=0.014 *    (e)          P=0.465      P=0.095     |P=0.603      P=0.503N     P=0.500N     P=0.752N     |
|LOGISTIC REGRESSION|     P=0.043 *    (e)          P=0.531      P=0.162     |P=0.637      (e)          (e)          P=0.713N     |
|COCH-ARM / FISHERS |     P=0.019 *    (e)          P=0.495      P=0.117     |P=0.594      P=0.500N     P=0.505N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    5/49 (10%)   3/49 (6%)   |2/50 (4%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     8.9%         0.0%         12.6%        7.7%        |4.6%         2.4%         0.0%         2.3%         |
|TERMINAL (d)       |     4/39 (10%)   0/39 (0%)    5/27 (19%)   3/26 (12%)  |2/29 (7%)    1/31 (3%)    0/33 (0%)    1/36 (3%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |731 (T)      731 (T)      ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.266      P=0.063N     P=0.277      P=0.596     |P=0.309N     P=0.477N     P=0.210N     P=0.424N     |
|POLY 3             |     P=0.396      P=0.054N     P=0.422      P=0.578N    |P=0.363N     P=0.509N     P=0.242N     P=0.492N     |
|POLY 1.5           |     P=0.423      P=0.056N     P=0.452      P=0.557N    |P=0.365N     P=0.509N     P=0.245N     P=0.496N     |
|POLY 6             |     P=0.367      P=0.053N     P=0.381      P=0.602N    |P=0.361N     P=0.505N     P=0.236N     P=0.486N     |
|LOGISTIC REGRESSION|     P=0.266      (e)          P=0.277      P=0.596     |P=0.309N     P=0.477N     (e)          P=0.424N     |
|COCH-ARM / FISHERS |     P=0.488      P=0.059N     P=0.487      P=0.511N    |P=0.367N     P=0.500N     P=0.253N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    4/49 (8%)    0/49 (0%)   |2/50 (4%)    1/50 (2%)    1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         9.8%         0.0%        |4.6%         2.4%         2.4%         2.3%         |
|TERMINAL (d)       |     1/39 (3%)    2/39 (5%)    2/27 (7%)    0/26 (0%)   |0/29 (0%)    1/31 (3%)    0/33 (0%)    1/36 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      502          ---         |586          731 (T)      570          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.518N     P=0.500      P=0.112      P=0.581N    |P=0.373N     P=0.495N     P=0.509N     P=0.458N     |
|POLY 3             |     P=0.462N     P=0.517      P=0.149      P=0.529N    |P=0.403N     P=0.513N     P=0.508N     P=0.496N     |
|POLY 1.5           |     P=0.436N     P=0.511      P=0.160      P=0.521N    |P=0.406N     P=0.511N     P=0.512N     P=0.498N     |
|POLY 6             |     P=0.490N     P=0.521      P=0.135      P=0.537N    |P=0.400N     P=0.512N     P=0.500N     P=0.492N     |
|LOGISTIC REGRESSION|     P=0.386N     P=0.500      P=0.187      (e)         |P=0.414N     P=0.500N     P=0.469N     P=0.503N     |
|COCH-ARM / FISHERS |     P=0.381N     P=0.500      P=0.175      P=0.505N    |P=0.410N     P=0.500N     P=0.508N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  10/50 (20%)  18/49 (37%)  12/49 (24%) |10/50 (20%)  6/50 (12%)   10/49 (20%)  5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     30.5%        21.1%        42.2%        30.5%       |22.6%        14.0%        23.1%        11.4%        |
|TERMINAL (d)       |     12/39 (31%)  9/39 (23%)   11/27 (41%)  10/26 (39%) |6/29 (21%)   3/31 (10%)   6/33 (18%)   5/36 (14%)   |
|FIRST INCIDENCE    |     459          670          430          663         |586          592          537          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.135      P=0.233N     P=0.054      P=0.340     |P=0.104N     P=0.192N     P=0.516N     P=0.070N     |
|POLY 3             |     P=0.321      P=0.211N     P=0.176      P=0.592     |P=0.161N     P=0.225N     P=0.577      P=0.129N     |
|POLY 1.5           |     P=0.386      P=0.221N     P=0.202      P=0.544N    |P=0.163N     P=0.223N     P=0.566      P=0.130N     |
|POLY 6             |     P=0.257      P=0.204N     P=0.144      P=0.538     |P=0.161N     P=0.218N     P=0.601      P=0.128N     |
|LOGISTIC REGRESSION|     P=0.382      P=0.210N     P=0.209      P=0.581     |P=0.161N     P=0.217N     P=0.570      P=0.121N     |
|COCH-ARM / FISHERS |     P=0.535      P=0.241N     P=0.238      P=0.433N    |P=0.171N     P=0.207N     P=0.579      P=0.131N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/49 (4%)    2/49 (4%)   |5/50 (10%)   7/50 (14%)   1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         4.9%         5.1%        |11.3%        15.8%        2.3%         2.3%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    0/27 (0%)    1/26 (4%)   |1/29 (3%)    2/31 (7%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     621          729 (T)      563          670         |521          456          72           708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252      P=0.751N     P=0.443      P=0.424     |P=0.023N*    P=0.392      P=0.102N     P=0.093N     |
|POLY 3             |     P=0.273      P=0.752N     P=0.462      P=0.449     |P=0.023N*    P=0.382      P=0.107N     P=0.101N     |
|POLY 1.5           |     P=0.290      P=0.754N     P=0.476      P=0.463     |P=0.023N*    P=0.374      P=0.108N     P=0.101N     |
|POLY 6             |     P=0.255      P=0.750N     P=0.442      P=0.433     |P=0.022N*    P=0.400      P=0.103N     P=0.099N     |
|LOGISTIC REGRESSION|     P=0.388      P=0.734      P=0.566      P=0.494     |P=0.024N*    P=0.435      P=0.049N*    P=0.106N     |
|COCH-ARM / FISHERS |     P=0.329      P=0.753N     P=0.492      P=0.492     |P=0.025N*    P=0.380      P=0.107N     P=0.102N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    6/49 (12%)   6/49 (12%)  |3/50 (6%)    5/50 (10%)   4/49 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     13.3%        6.3%         15.0%        15.3%       |6.8%         11.8%        9.5%         9.0%         |
|TERMINAL (d)       |     5/39 (13%)   2/39 (5%)    4/27 (15%)   4/26 (15%)  |1/29 (3%)    2/31 (7%)    4/33 (12%)   3/36 (8%)    |
|FIRST INCIDENCE    |     669          621          663          663         |521          670          731 (T)      621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.180      P=0.235N     P=0.380      P=0.369     |P=0.550N     P=0.368      P=0.536      P=0.568      |
|POLY 3             |     P=0.303      P=0.217N     P=0.534      P=0.521     |P=0.507      P=0.333      P=0.472      P=0.503      |
|POLY 1.5           |     P=0.334      P=0.226N     P=0.567      P=0.547     |P=0.503      P=0.337      P=0.472      P=0.501      |
|POLY 6             |     P=0.270      P=0.211N     P=0.488      P=0.491     |P=0.514      P=0.337      P=0.478      P=0.509      |
|LOGISTIC REGRESSION|     P=0.283      P=0.229N     P=0.476      P=0.487     |P=0.506      P=0.366      P=0.491      P=0.487      |
|COCH-ARM / FISHERS |     P=0.406      P=0.243N     P=0.606      P=0.606     |P=0.499      P=0.357      P=0.489      P=0.500      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Karyomegaly                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         0.0%         0.0%         2.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/39 (5%)    0/39 (0%)    0/27 (0%)    1/26 (4%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.579N     P=0.238N     P=0.322N     P=0.640N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.481N     P=0.227N     P=0.266N     P=0.550N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.474N     P=0.230N     P=0.255N     P=0.537N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.488N     P=0.224N     P=0.282N     P=0.565N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.579N     (e)          (e)          P=0.640N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.467N     P=0.247N     P=0.253N     P=0.508N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    7/49 (14%)   9/49 (18%)  |2/50 (4%)    8/50 (16%)   7/49 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     13.2%        4.2%         17.0%        21.3%       |4.6%         18.5%        16.2%        6.6%         |
|TERMINAL (d)       |     4/39 (10%)   0/39 (0%)    2/27 (7%)    3/26 (12%)  |1/29 (3%)    3/31 (10%)   3/33 (9%)    1/36 (3%)    |
|FIRST INCIDENCE    |     663          611          511          374         |645          592          537          529          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.034 *    P=0.128N     P=0.298      P=0.155     |P=0.425N     P=0.063      P=0.108      P=0.547      |
|POLY 3             |     P=0.058      P=0.116N     P=0.424      P=0.235     |P=0.462N     P=0.044 *    P=0.076      P=0.519      |
|POLY 1.5           |     P=0.065      P=0.122N     P=0.452      P=0.244     |P=0.479N     P=0.043 *    P=0.073      P=0.510      |
|POLY 6             |     P=0.052      P=0.112N     P=0.387      P=0.224     |P=0.439N     P=0.048 *    P=0.085      P=0.530      |
|LOGISTIC REGRESSION|     P=0.166      P=0.163N     P=0.480      P=0.346     |P=0.507N     P=0.046 *    P=0.076      P=0.483      |
|COCH-ARM / FISHERS |     P=0.085      P=0.134N     P=0.484      P=0.274     |P=0.502N     P=0.046 *    P=0.075      P=0.500      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Kupffer Cell                                                                                                              |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    8/49 (16%)   30/49 (61%) |0/50 (0%)    5/50 (10%)   25/49 (51%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         19.5%        69.9%       |0.0%         11.5%        54.1%        92.2%        |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    4/27 (15%)   16/26 (62%) |0/29 (0%)    1/31 (3%)    15/33 (46%)  34/36 (94%)  |
|FIRST INCIDENCE    |     ---          ---          567          374         |---          369          408          489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.002 **   P<0.001 **  |P<0.001 **   P=0.039 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   (e)          P=0.002 **   P<0.001 **  |P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   (e)          P=0.003 **   P<0.001 **  |P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   (e)          P=0.002 **   P<0.001 **  |P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.004 **   P<0.001 **  |P<0.001 **   P=0.044 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.003 **   P<0.001 **  |P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Oval Cell                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/49 (4%)    3/49 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         5.0%         7.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/39 (3%)    0/39 (0%)    2/27 (7%)    3/26 (12%)  |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      681          729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.074      P=0.747N     P=0.372      P=0.173     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.122      P=0.749N     P=0.457      P=0.256     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.133      P=0.753N     P=0.473      P=0.268     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.110      P=0.745N     P=0.433      P=0.241     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.095      P=0.765N     P=0.372      P=0.173     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.159      P=0.753N     P=0.492      P=0.301     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   5/49 (10%)   3/50 (6%)   |10/50 (20%)  2/50 (4%)    6/50 (12%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     11.0%        10.6%        12.6%        7.5%        |22.9%        4.8%         13.8%        13.6%        |
|TERMINAL (d)       |     4/39 (10%)   5/39 (13%)   4/27 (15%)   1/26 (4%)   |7/29 (24%)   2/31 (7%)    4/33 (12%)   6/36 (17%)   |
|FIRST INCIDENCE    |     556          729 (T)      705          614         |572          731 (T)      72           731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.530N     P=0.629N     P=0.412      P=0.526N    |P=0.218N     P=0.014N*    P=0.164N     P=0.110N     |
|POLY 3             |     P=0.373N     P=0.607N     P=0.543      P=0.426N    |P=0.305N     P=0.016N*    P=0.205N     P=0.198N     |
|POLY 1.5           |     P=0.343N     P=0.614N     P=0.577      P=0.404N    |P=0.312N     P=0.015N*    P=0.212N     P=0.202N     |
|POLY 6             |     P=0.407N     P=0.604N     P=0.497      P=0.450N    |P=0.299N     P=0.015N*    P=0.189N     P=0.191N     |
|LOGISTIC REGRESSION|     P=0.368N     P=0.612N     P=0.532      P=0.368N    |P=0.325N     P=0.016N*    P=0.194N     P=0.177N     |
|COCH-ARM / FISHERS |     P=0.281N     P=0.630N     P=0.617      P=0.357N    |P=0.329N     P=0.014N*    P=0.207N     P=0.207N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    4/49 (8%)    4/50 (8%)   |3/50 (6%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     13.3%        2.1%         10.1%        10.0%       |7.0%         4.7%         7.1%         4.5%         |
|TERMINAL (d)       |     5/39 (13%)   1/39 (3%)    4/27 (15%)   3/26 (12%)  |2/29 (7%)    1/31 (3%)    2/33 (6%)    2/36 (6%)    |
|FIRST INCIDENCE    |     667          729 (T)      729 (T)      604         |713          255          723          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.414      P=0.058N     P=0.602N     P=0.597N    |P=0.378N     P=0.487N     P=0.605N     P=0.419N     |
|POLY 3             |     P=0.565N     P=0.049N*    P=0.453N     P=0.449N    |P=0.447N     P=0.502N     P=0.651      P=0.490N     |
|POLY 1.5           |     P=0.538N     P=0.052N     P=0.421N     P=0.424N    |P=0.451N     P=0.504N     P=0.647      P=0.495N     |
|POLY 6             |     P=0.542      P=0.048N*    P=0.501N     P=0.481N    |P=0.440N     P=0.497N     P=0.663      P=0.483N     |
|LOGISTIC REGRESSION|     P=0.525      P=0.049N*    P=0.537N     P=0.465N    |P=0.456N     P=0.449N     P=0.645N     P=0.467N     |
|COCH-ARM / FISHERS |     P=0.483N     P=0.056N     P=0.383N     P=0.370N    |P=0.456N     P=0.500N     P=0.661N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    2/49 (4%)    4/50 (8%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     13.3%        2.1%         5.0%         10.1%       |4.6%         4.8%         0.0%         4.5%         |
|TERMINAL (d)       |     6/39 (15%)   1/39 (3%)    1/27 (4%)    4/26 (15%)  |2/29 (7%)    2/31 (7%)    0/33 (0%)    2/36 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      663          729 (T)     |731 (T)      731 (T)      ---          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.474      P=0.058N     P=0.274N     P=0.636     |P=0.477N     P=0.672N     P=0.210N     P=0.615N     |
|POLY 3             |     P=0.508N     P=0.048N*    P=0.174N     P=0.453N    |P=0.552N     P=0.685      P=0.242N     P=0.686N     |
|POLY 1.5           |     P=0.486N     P=0.051N     P=0.158N     P=0.426N    |P=0.555N     P=0.685      P=0.244N     P=0.689N     |
|POLY 6             |     P=0.533N     P=0.046N*    P=0.198N     P=0.487N    |P=0.548N     P=0.690      P=0.236N     P=0.680N     |
|LOGISTIC REGRESSION|     P=0.540      P=0.058N     P=0.218N     P=0.636     |P=0.477N     P=0.672N     (e)          P=0.615N     |
|COCH-ARM / FISHERS |     P=0.444N     P=0.056N     P=0.141N     P=0.370N    |P=0.556N     P=0.691N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Perivascular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |1/29 (3%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |713          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.104N     P=0.239N     P=0.220N     P=0.213N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.112N     P=0.243N     P=0.243N     P=0.232N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.113N     P=0.243N     P=0.245N     P=0.235N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.113N     P=0.241N     P=0.237N     P=0.228N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.110N     P=0.238N     P=0.233N     P=0.225N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/38 (5%)    0/35 (0%)    1/33 (3%)    0/35 (0%)   |1/41 (2%)    6/39 (15%)   4/41 (10%)   1/37 (3%)    |
|POLY-3 ADJUSTED (b)|     6.0%         0.0%         3.5%         0.0%        |2.8%         17.2%        10.8%        3.0%         |
|TERMINAL (d)       |     2/29 (7%)    0/27 (0%)    1/23 (4%)    0/18 (0%)   |1/24 (4%)    5/26 (19%)   3/29 (10%)   1/27 (4%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |731 (T)      647          537          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.268N     P=0.254N     P=0.581N     P=0.348N    |P=0.294N     P=0.070      P=0.223      P=0.736N     |
|POLY 3             |     P=0.229N     P=0.237N     P=0.555N     P=0.293N    |P=0.353N     P=0.052      P=0.192      P=0.747      |
|POLY 1.5           |     P=0.221N     P=0.244N     P=0.551N     P=0.282N    |P=0.366N     P=0.049 *    P=0.185      P=0.743      |
|POLY 6             |     P=0.236N     P=0.233N     P=0.561N     P=0.304N    |P=0.333N     P=0.055      P=0.205      P=0.753      |
|LOGISTIC REGRESSION|     P=0.268N     (e)          P=0.581N     (e)         |P=0.371N     P=0.056      P=0.179      P=0.736N     |
|COCH-ARM / FISHERS |     P=0.203N     P=0.268N     P=0.553N     P=0.268N    |P=0.384N     P=0.047 *    P=0.180      P=0.727      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/24 (0%)    1/26 (4%)    1/32 (3%)    1/25 (4%)   |1/37 (3%)    2/38 (5%)    2/40 (5%)    1/38 (3%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.0%         3.8%         5.0%        |3.1%         6.4%         6.0%         3.0%         |
|TERMINAL (d)       |     0/19 (0%)    1/21 (5%)    0/16 (0%)    1/15 (7%)   |1/23 (4%)    2/22 (9%)    2/28 (7%)    0/26 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      430          729 (T)     |731 (T)      731 (T)      731 (T)      708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.322      P=0.520      P=0.496      P=0.453     |P=0.503N     P=0.484      P=0.569      P=0.741N     |
|POLY 3             |     P=0.341      P=0.523      P=0.534      P=0.482     |P=0.544N     P=0.487      P=0.513      P=0.755N     |
|POLY 1.5           |     P=0.355      P=0.521      P=0.545      P=0.489     |P=0.544N     P=0.492      P=0.512      P=0.755N     |
|POLY 6             |     P=0.325      P=0.525      P=0.518      P=0.474     |P=0.544N     P=0.485      P=0.519      P=0.756N     |
|LOGISTIC REGRESSION|     P=0.484      P=0.520      (e)          P=0.453     |P=0.543N     P=0.484      P=0.569      P=0.760N     |
|COCH-ARM / FISHERS |     P=0.391      P=0.520      P=0.571      P=0.510     |P=0.547N     P=0.510      P=0.530      P=0.747N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/40 (0%)    0/33 (0%)    0/40 (0%)    0/37 (0%)   |2/31 (6%)    2/40 (5%)    5/38 (13%)   0/34 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |7.2%         5.9%         15.5%        0.0%         |
|TERMINAL (d)       |     0/31 (0%)    0/25 (0%)    0/22 (0%)    0/18 (0%)   |0/18 (0%)    1/25 (4%)    5/26 (19%)   0/22 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |645          647          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.221N     P=0.661N     P=0.339      P=0.225N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.268N     P=0.618N     P=0.277      P=0.229N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.257N     P=0.614N     P=0.278      P=0.224N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.281N     P=0.619N     P=0.282      P=0.234N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.259N     P=0.600N     P=0.290      P=0.209N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.245N     P=0.591N     P=0.307      P=0.224N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/47 (0%)    1/43 (2%)   |0/47 (0%)    0/48 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         4.2%         0.0%         2.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/39 (3%)    2/39 (5%)    0/27 (0%)    0/24 (0%)   |0/28 (0%)    0/30 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     642          729 (T)      ---          694         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.426N     P=0.685N     P=0.304N     P=0.605N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.370N     P=0.679N     P=0.273N     P=0.593N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.359N     P=0.683N     P=0.263N     P=0.581N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.385N     P=0.677N     P=0.289N     P=0.606N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.374N     P=0.693N     P=0.249N     P=0.569N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.341N     P=0.691N     P=0.263N     P=0.557N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/47 (2%)    0/43 (0%)   |0/47 (0%)    1/48 (2%)    1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.2%         6.3%         2.6%         0.0%        |0.0%         2.5%         2.4%         2.3%         |
|TERMINAL (d)       |     1/39 (3%)    2/39 (5%)    0/27 (0%)    0/24 (0%)   |0/28 (0%)    1/30 (3%)    1/33 (3%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      707          563          ---         |---          731 (T)      731 (T)      708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.307N     P=0.309      P=0.715      P=0.597N    |P=0.433      P=0.514      P=0.533      P=0.511      |
|POLY 3             |     P=0.272N     P=0.324      P=0.730      P=0.553N    |P=0.410      P=0.501      P=0.507      P=0.517      |
|POLY 1.5           |     P=0.260N     P=0.317      P=0.738      P=0.546N    |P=0.406      P=0.500      P=0.505      P=0.515      |
|POLY 6             |     P=0.289N     P=0.328      P=0.718      P=0.560N    |P=0.417      P=0.503      P=0.512      P=0.521      |
|LOGISTIC REGRESSION|     P=0.239N     P=0.326      P=0.755N     (e)         |P=0.413      P=0.514      P=0.533      P=0.516      |
|COCH-ARM / FISHERS |     P=0.235N     P=0.309      P=0.737      P=0.538N    |P=0.399      P=0.505      P=0.510      P=0.515      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   4/47 (9%)    4/43 (9%)   |1/47 (2%)    2/48 (4%)    3/49 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     15.6%        14.8%        10.3%        11.5%       |2.5%         4.9%         7.1%         6.8%         |
|TERMINAL (d)       |     7/39 (18%)   7/39 (18%)   2/27 (7%)    2/24 (8%)   |1/28 (4%)    2/30 (7%)    3/33 (9%)    1/36 (3%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      681          684         |731 (T)      731 (T)      731 (T)      656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.457N     P=0.615      P=0.487N     P=0.548N    |P=0.310      P=0.524      P=0.365      P=0.368      |
|POLY 3             |     P=0.310N     P=0.576N     P=0.348N     P=0.425N    |P=0.265      P=0.501      P=0.317      P=0.338      |
|POLY 1.5           |     P=0.287N     P=0.588N     P=0.324N     P=0.405N    |P=0.259      P=0.501      P=0.314      P=0.333      |
|POLY 6             |     P=0.337N     P=0.567N     P=0.382N     P=0.445N    |P=0.275      P=0.505      P=0.326      P=0.347      |
|LOGISTIC REGRESSION|     P=0.386N     P=0.615      P=0.424N     P=0.481N    |P=0.265      P=0.524      P=0.365      P=0.333      |
|COCH-ARM / FISHERS |     P=0.237N     P=0.613N     P=0.299N     P=0.356N    |P=0.249      P=0.508      P=0.324      P=0.332      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.6%         4.8%         2.4%         4.5%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/29 (0%)    2/31 (7%)    1/33 (3%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |521          731 (T)      731 (T)      660          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.534N     P=0.691      P=0.489N     P=0.686N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.570N     P=0.679      P=0.514N     P=0.688N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.574N     P=0.682      P=0.515N     P=0.691N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.564N     P=0.680      P=0.508N     P=0.682N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.577N     P=0.692N     P=0.484N     P=0.683      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.577N     P=0.691N     P=0.500N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/5 (100%)   2/3 (67%)    2/3 (67%)    0/1 (0%)    |7/10 (70%)   3/4 (75%)    4/5 (80%)    9/9 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       66.7%        78.5%        0.0%        |72.3%        79.6%        82.1%        100.0%       |
|TERMINAL (d)       |     5/5 (100%)   2/3 (67%)    2/2 (100%)   0/0 (0%)    |3/5 (60%)    1/1 (100%)   3/3 (100%)   5/5 (100%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |521          456          591          529          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.815N     P=0.398N     P=1.000N     P=1.000N    |P=0.267      P=0.461N     P=0.435N     P=0.396      |
|POLY 3             |     P=0.095N     P=0.392N     P=0.695N     P=1.000N    |P=0.081      P=0.657      P=0.590      P=0.130      |
|POLY 1.5           |     P=0.070N     P=0.392N     P=0.524N     P<0.001N**  |P=0.079      P=0.663      P=0.584      P=0.122      |
|POLY 6             |     P=0.233N     P=0.392N     P=0.973N     P=1.000N    |P=0.087      P=0.640      P=0.594      P=0.149      |
|LOGISTIC REGRESSION|     P=0.815N     P=0.398N     P=1.000N     (e)         |P=0.056      P=0.714N     P=0.513      P=0.104      |
|COCH-ARM / FISHERS |     P=0.061N     P=0.375N     P=0.375N     P=0.167N    |P=0.073      P=0.790N     P=0.593      P=0.124      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   2/48 (4%)    2/48 (4%)   |2/50 (4%)    3/50 (6%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         12.6%        5.1%         5.2%        |4.6%         7.2%         2.4%         0.0%         |
|TERMINAL (d)       |     1/39 (3%)    4/39 (10%)   2/27 (7%)    2/26 (8%)   |1/29 (3%)    2/31 (7%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     669          681          729 (T)      729 (T)     |725          723          723          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.559N     P=0.151      P=0.570      P=0.565     |P=0.080N     P=0.521      P=0.461N     P=0.201N     |
|POLY 3             |     P=0.445N     P=0.150      P=0.643      P=0.632     |P=0.101N     P=0.488      P=0.515N     P=0.232N     |
|POLY 1.5           |     P=0.418N     P=0.144      P=0.660      P=0.647     |P=0.103N     P=0.489      P=0.518N     P=0.234N     |
|POLY 6             |     P=0.480N     P=0.153      P=0.618      P=0.614     |P=0.097N     P=0.494      P=0.504N     P=0.228N     |
|LOGISTIC REGRESSION|     P=0.479N     P=0.145      P=0.628      P=0.625     |P=0.092N     P=0.502      P=0.489N     P=0.220N     |
|COCH-ARM / FISHERS |     P=0.366N     P=0.134      P=0.676      P=0.676     |P=0.105N     P=0.500      P=0.508N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    3/48 (6%)    0/48 (0%)   |2/50 (4%)    4/50 (8%)    2/49 (4%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     8.8%         8.4%         7.6%         0.0%        |4.6%         9.3%         4.9%         9.0%         |
|TERMINAL (d)       |     3/39 (8%)    2/39 (5%)    3/27 (11%)   0/26 (0%)   |1/29 (3%)    3/31 (10%)   2/33 (6%)    3/36 (8%)    |
|FIRST INCIDENCE    |     642          681          729 (T)      ---         |621          255          731 (T)      682          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.107N     P=0.625N     P=0.626      P=0.117N    |P=0.431      P=0.359      P=0.659N     P=0.414      |
|POLY 3             |     P=0.071N     P=0.617N     P=0.576N     P=0.085N    |P=0.352      P=0.331      P=0.676      P=0.345      |
|POLY 1.5           |     P=0.062N     P=0.626N     P=0.551N     P=0.078N    |P=0.347      P=0.332      P=0.673      P=0.342      |
|POLY 6             |     P=0.082N     P=0.611N     P=0.612N     P=0.093N    |P=0.360      P=0.334      P=0.684      P=0.352      |
|LOGISTIC REGRESSION|     P=0.071N     P=0.633N     P=0.613N     P=0.083N    |P=0.342      P=0.383      P=0.680      P=0.344      |
|COCH-ARM / FISHERS |     P=0.047N*    P=0.643N     P=0.523N     P=0.064N    |P=0.343      P=0.339      P=0.684      P=0.339      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/48 (6%)    1/48 (2%)   |6/50 (12%)   14/50 (28%)  11/49 (22%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         7.5%         2.6%        |13.8%        33.2%        26.7%        26.9%        |
|TERMINAL (d)       |     1/39 (3%)    2/39 (5%)    2/27 (7%)    1/26 (4%)   |5/29 (17%)   12/31 (39%)  11/33 (33%)  10/36 (28%)  |
|FIRST INCIDENCE    |     729 (T)      729 (T)      583          729 (T)     |621          670          731 (T)      621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.471      P=0.500      P=0.207      P=0.669     |P=0.357      P=0.051      P=0.205      P=0.194      |
|POLY 3             |     P=0.529      P=0.517      P=0.263      P=0.723     |P=0.201      P=0.028 *    P=0.112      P=0.102      |
|POLY 1.5           |     P=0.554      P=0.511      P=0.276      P=0.732     |P=0.191      P=0.030 *    P=0.112      P=0.099      |
|POLY 6             |     P=0.503      P=0.521      P=0.245      P=0.713     |P=0.219      P=0.029 *    P=0.121      P=0.110      |
|LOGISTIC REGRESSION|     P=0.553      P=0.500      P=0.277      P=0.669     |P=0.221      P=0.034 *    P=0.144      P=0.109      |
|COCH-ARM / FISHERS |     P=0.596N     P=0.500      P=0.293      P=0.742     |P=0.182      P=0.039 *    P=0.133      P=0.096      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    10/50 (20%)  5/48 (10%)   5/48 (10%)  |17/50 (34%)  35/50 (70%)  26/49 (53%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     8.9%         20.9%        12.6%        12.9%       |38.8%        77.3%        61.9%        51.4%        |
|TERMINAL (d)       |     4/39 (10%)   6/39 (15%)   3/27 (11%)   3/26 (12%)  |14/29 (48%)  25/31 (81%)  22/33 (67%)  21/36 (58%)  |
|FIRST INCIDENCE    |     729 (T)      656          655          629         |621          456          570          582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.373      P=0.089      P=0.298      P=0.291     |P=0.251N     P<0.001 **   P=0.121      P=0.408      |
|POLY 3             |     P=0.527      P=0.092      P=0.423      P=0.407     |P=0.481      P<0.001 **   P=0.022 *    P=0.160      |
|POLY 1.5           |     P=0.552N     P=0.085      P=0.446      P=0.426     |P=0.464      P<0.001 **   P=0.023 *    P=0.156      |
|POLY 6             |     P=0.489      P=0.099      P=0.390      P=0.388     |P=0.507      P<0.001 **   P=0.027 *    P=0.171      |
|LOGISTIC REGRESSION|     P=0.511      P=0.088      P=0.368      P=0.383     |P=0.522      P<0.001 **   P=0.034 *    P=0.187      |
|COCH-ARM / FISHERS |     P=0.477N     P=0.074      P=0.474      P=0.474     |P=0.448      P<0.001 **   P=0.043 *    P=0.154      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    0/49 (0%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         0.0%         4.9%         2.3%         |
|TERMINAL (d)       |                                                        |2/29 (7%)    0/31 (0%)    2/32 (6%)    1/35 (3%)    |
|FIRST INCIDENCE    |                                                        |731 (T)      ---          731 (T)      731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.469N     P=0.223N     P=0.660N     P=0.434N     |
|POLY 3             |                                                        |P=0.526N     P=0.246N     P=0.677      P=0.500N     |
|POLY 1.5           |                                                        |P=0.529N     P=0.246N     P=0.674      P=0.503N     |
|POLY 6             |                                                        |P=0.525N     P=0.241N     P=0.686      P=0.494N     |
|LOGISTIC REGRESSION|                                                        |P=0.469N     (e)          P=0.660N     P=0.434N     |
|COCH-ARM / FISHERS |                                                        |P=0.536N     P=0.253N     P=0.684      P=0.508N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    2/49 (4%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         4.8%         4.8%         2.3%         |
|TERMINAL (d)       |                                                        |0/29 (0%)    1/31 (3%)    0/32 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |                                                        |713          715          537          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.524N     P=0.497      P=0.516      P=0.751N     |
|POLY 3             |                                                        |P=0.552N     P=0.486      P=0.488      P=0.761N     |
|POLY 1.5           |                                                        |P=0.556N     P=0.486      P=0.484      P=0.759      |
|POLY 6             |                                                        |P=0.545N     P=0.492      P=0.498      P=0.757N     |
|LOGISTIC REGRESSION|                                                        |P=0.560N     P=0.494      P=0.507      P=0.762N     |
|COCH-ARM / FISHERS |                                                        |P=0.562N     P=0.492      P=0.492      P=0.747      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |11/50 (22%)  12/49 (24%)  19/49 (39%)  16/49 (33%)  |
|POLY-3 ADJUSTED (b)|                                                        |24.5%        28.7%        43.4%        35.6%        |
|TERMINAL (d)       |                                                        |7/29 (24%)   8/31 (26%)   12/32 (38%)  12/35 (34%)  |
|FIRST INCIDENCE    |                                                        |521          672          196          485          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.243      P=0.540      P=0.108      P=0.329      |
|POLY 3             |                                                        |P=0.121      P=0.421      P=0.046 *    P=0.177      |
|POLY 1.5           |                                                        |P=0.113      P=0.434      P=0.044 *    P=0.172      |
|POLY 6             |                                                        |P=0.132      P=0.421      P=0.054      P=0.186      |
|LOGISTIC REGRESSION|                                                        |P=0.107      P=0.459      P=0.054      P=0.166      |
|COCH-ARM / FISHERS |                                                        |P=0.102      P=0.478      P=0.055      P=0.168      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/49 (0%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         0.0%         4.9%         0.0%         |
|TERMINAL (d)       |                                                        |1/29 (3%)    0/31 (0%)    2/32 (6%)    0/35 (0%)    |
|FIRST INCIDENCE    |                                                        |731 (T)      ---          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.415N     P=0.487N     P=0.535      P=0.462N     |
|POLY 3             |                                                        |P=0.455N     P=0.508N     P=0.483      P=0.500N     |
|POLY 1.5           |                                                        |P=0.458N     P=0.508N     P=0.481      P=0.502N     |
|POLY 6             |                                                        |P=0.452N     P=0.504N     P=0.492      P=0.497N     |
|LOGISTIC REGRESSION|                                                        |P=0.415N     (e)          P=0.535      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.465N     P=0.505N     P=0.492      P=0.505N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  4/50 (8%)    2/47 (4%)    4/47 (9%)   |6/49 (12%)   4/50 (8%)    2/49 (4%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     22.1%        8.4%         5.1%         10.5%       |14.1%        9.5%         4.8%         17.8%        |
|TERMINAL (d)       |     9/39 (23%)   3/39 (8%)    2/27 (7%)    3/26 (12%)  |5/29 (17%)   3/31 (10%)   2/33 (6%)    6/36 (17%)   |
|FIRST INCIDENCE    |     642          681          729 (T)      670         |715          694          731 (T)      437          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.185N     P=0.073N     P=0.061N     P=0.236N    |P=0.377      P=0.339N     P=0.098N     P=0.529      |
|POLY 3             |     P=0.093N     P=0.060N     P=0.026N*    P=0.131N    |P=0.289      P=0.376N     P=0.136N     P=0.428      |
|POLY 1.5           |     P=0.084N     P=0.064N     P=0.022N*    P=0.119N    |P=0.282      P=0.374N     P=0.139N     P=0.418      |
|POLY 6             |     P=0.105N     P=0.056N     P=0.033N*    P=0.147N    |P=0.296      P=0.370N     P=0.129N     P=0.442      |
|LOGISTIC REGRESSION|     P=0.124N     P=0.059N     P=0.039N*    P=0.150N    |P=0.287      P=0.365N     P=0.110N     P=0.412      |
|COCH-ARM / FISHERS |     P=0.070N     P=0.074N     P=0.018N*    P=0.092N    |P=0.270      P=0.357N     P=0.134N     P=0.403      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Cytoplasmic Alteration                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/47 (0%)    1/47 (2%)   |1/49 (2%)    2/50 (4%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         2.6%        |2.4%         4.8%         0.0%         4.5%         |
|TERMINAL (d)       |     1/39 (3%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |1/29 (3%)    1/31 (3%)    0/33 (0%)    1/36 (3%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          663         |731 (T)      712          ---          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.524      P=0.500N     P=0.573N     P=0.694     |P=0.521      P=0.515      P=0.474N     P=0.562      |
|POLY 3             |     P=0.557      P=0.490N     P=0.528N     P=0.723     |P=0.481      P=0.496      P=0.503N     P=0.515      |
|POLY 1.5           |     P=0.564      P=0.494N     P=0.520N     P=0.730     |P=0.478      P=0.497      P=0.504N     P=0.511      |
|POLY 6             |     P=0.549      P=0.488N     P=0.539N     P=0.716     |P=0.488      P=0.499      P=0.498N     P=0.521      |
|LOGISTIC REGRESSION|     P=0.570      (e)          (e)          P=0.736     |P=0.484      P=0.501      (e)          P=0.511      |
|COCH-ARM / FISHERS |     P=0.581      P=0.500N     P=0.515N     P=0.737     |P=0.474      P=0.508      P=0.500N     P=0.508      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/47 (0%)    0/47 (0%)   |0/49 (0%)    0/50 (0%)    3/49 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |0.0%         0.0%         7.1%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    3/33 (9%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          705          ---          ---         |---          ---          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.632N     P=0.510      (e)          (e)         |P=0.593      (e)          P=0.144      (e)          |
|POLY 3             |     P=0.585N     P=0.510      (e)          (e)         |P=0.561      (e)          P=0.116      (e)          |
|POLY 1.5           |     P=0.581N     P=0.507      (e)          (e)         |P=0.555      (e)          P=0.115      (e)          |
|POLY 6             |     P=0.592N     P=0.513      (e)          (e)         |P=0.567      (e)          P=0.119      (e)          |
|LOGISTIC REGRESSION|     P=0.596N     P=0.500      (e)          (e)         |(e)          (e)          P=0.144      (e)          |
|COCH-ARM / FISHERS |     P=0.578N     P=0.500      (e)          (e)         |P=0.543      (e)          P=0.121      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/46 (0%)    0/48 (0%)   |1/50 (2%)    4/49 (8%)    0/48 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         9.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/27 (0%)    0/25 (0%)   |1/29 (3%)    2/30 (7%)    0/33 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      604          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.191      P=0.474N     P=0.462N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.123N     P=0.168      P=0.506N     P=0.500N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.125N     P=0.167      P=0.509N     P=0.502N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.173      P=0.500N     P=0.497N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.128N     P=0.168      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.175      P=0.510N     P=0.505N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   1/49 (2%)    2/46 (4%)    1/48 (2%)   |15/50 (30%)  15/49 (31%)  16/48 (33%)  20/49 (41%)  |
|POLY-3 ADJUSTED (b)|     11.3%        2.1%         5.2%         2.6%        |34.6%        36.0%        37.6%        45.7%        |
|TERMINAL (d)       |     4/38 (11%)   0/39 (0%)    1/27 (4%)    1/25 (4%)   |12/29 (41%)  12/30 (40%)  13/33 (39%)  17/35 (49%)  |
|FIRST INCIDENCE    |     669          549          563          729 (T)     |649          606          544          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.174N     P=0.097N     P=0.345N     P=0.210N    |P=0.335      P=0.551N     P=0.521N     P=0.414      |
|POLY 3             |     P=0.126N     P=0.088N     P=0.278N     P=0.138N    |P=0.148      P=0.537      P=0.472      P=0.196      |
|POLY 1.5           |     P=0.116N     P=0.093N     P=0.261N     P=0.127N    |P=0.139      P=0.533      P=0.446      P=0.187      |
|POLY 6             |     P=0.138N     P=0.084N     P=0.305N     P=0.153N    |P=0.162      P=0.561      P=0.517      P=0.216      |
|LOGISTIC REGRESSION|     P=0.093N     P=0.117N     P=0.261N     P=0.155N    |P=0.159      P=0.543      P=0.505      P=0.213      |
|COCH-ARM / FISHERS |     P=0.099N     P=0.102N     P=0.245N     P=0.107N    |P=0.128      P=0.560      P=0.445      P=0.180      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/46 (0%)    0/48 (0%)   |1/50 (2%)    2/49 (4%)    1/48 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         4.9%         2.4%         2.3%         |
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/27 (0%)    0/25 (0%)   |1/29 (3%)    2/30 (7%)    0/33 (0%)    1/35 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      731 (T)      544          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.480N     P=0.512      P=0.756N     P=0.720N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.528N     P=0.482      P=0.758      P=0.761N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.532N     P=0.483      P=0.753      P=0.758      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.521N     P=0.486      P=0.756N     P=0.757N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.533N     P=0.512      P=0.759N     P=0.720N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.537N     P=0.492      P=0.742      P=0.747      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    7/49 (14%)   6/49 (12%)   8/49 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     4.5%         15.1%        14.9%        20.1%       |                                                    |
|TERMINAL (d)       |     1/39 (3%)    6/38 (16%)   3/27 (11%)   4/26 (15%)  |                                                    |
|FIRST INCIDENCE    |     618          656          618          623         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.016 *    P=0.084      P=0.063      P=0.019 *   |                                                    |
|POLY 3             |     P=0.038 *    P=0.089      P=0.102      P=0.028 *   |                                                    |
|POLY 1.5           |     P=0.047 *    P=0.086      P=0.115      P=0.033 *   |                                                    |
|POLY 6             |     P=0.030 *    P=0.090      P=0.086      P=0.024 *   |                                                    |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.083      P=0.118      P=0.036 *   |                                                    |
|COCH-ARM / FISHERS |     P=0.072      P=0.080      P=0.134      P=0.046 *   |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    3/48 (6%)    4/45 (9%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         4.3%         7.3%         10.8%       |                                                    |
|TERMINAL (d)       |     0/38 (0%)    1/38 (3%)    0/27 (0%)    1/24 (4%)   |                                                    |
|FIRST INCIDENCE    |     ---          707          537          623         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.024 *    P=0.243      P=0.105      P=0.042 *   |                                                    |
|POLY 3             |     P=0.025 *    P=0.249      P=0.106      P=0.040 *   |                                                    |
|POLY 1.5           |     P=0.028 *    P=0.245      P=0.110      P=0.042 *   |                                                    |
|POLY 6             |     P=0.023 *    P=0.252      P=0.100      P=0.038 *   |                                                    |
|LOGISTIC REGRESSION|     P=0.059      P=0.249      P=0.128      P=0.052     |                                                    |
|COCH-ARM / FISHERS |     P=0.036 *    P=0.247      P=0.117      P=0.049 *   |                                                    |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    2/46 (4%)    3/46 (7%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         5.2%         7.7%        |                                                    |
|TERMINAL (d)       |     1/39 (3%)    0/39 (0%)    1/27 (4%)    0/26 (0%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      ---          705          402         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058      P=0.500N     P=0.378      P=0.232     |                                                    |
|POLY 3             |     P=0.075      P=0.492N     P=0.447      P=0.256     |                                                    |
|POLY 1.5           |     P=0.078      P=0.496N     P=0.459      P=0.261     |                                                    |
|POLY 6             |     P=0.071      P=0.489N     P=0.430      P=0.251     |                                                    |
|LOGISTIC REGRESSION|     P=0.166      (e)          P=0.414      P=0.402     |                                                    |
|COCH-ARM / FISHERS |     P=0.089      P=0.505N     P=0.468      P=0.278     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         5.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          ---          704          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.035 *    (e)          P=0.441      P=0.154     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.055      (e)          P=0.476      P=0.209     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.059      (e)          P=0.485      P=0.218     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.050      (e)          P=0.463      P=0.199     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.045 *    (e)          P=0.475      P=0.154     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.495      P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    13/49 (27%)  8/50 (16%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         6.3%         30.1%        19.7%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/39 (5%)    1/39 (3%)    5/27 (19%)   3/26 (12%)  |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      656          537          596         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.005 **   P=0.510      P<0.001 **   P=0.019 *   |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.006 **   P=0.525      P<0.001 **   P=0.030 *   |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.008 **   P=0.516      P<0.001 **   P=0.034 *   |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.004 **   P=0.534      P<0.001 **   P=0.027 *   |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.024 *    P=0.511      P=0.003 **   P=0.033 *   |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.020 *    P=0.500      P=0.002 **   P=0.046 *   |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    11/49 (22%)  8/50 (16%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.3%         25.7%        19.7%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    4/27 (15%)   3/26 (12%)  |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          656          537          596         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.131      P<0.001 **   P=0.002 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.129      P<0.001 **   P=0.002 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.126      P<0.001 **   P=0.002 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.132      P<0.001 **   P=0.002 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.005 **   P=0.110      P<0.001 **   P=0.003 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.004 **   P=0.121      P<0.001 **   P=0.003 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  11/50 (22%)  26/48 (54%)  42/49 (86%) |24/50 (48%)  29/50 (58%)  32/49 (65%)  35/50 (70%)  |
|POLY-3 ADJUSTED (b)|     25.2%        22.7%        58.5%        87.8%       |52.1%        61.6%        69.6%        73.4%        |
|TERMINAL (d)       |     6/39 (15%)   6/39 (15%)   13/27 (48%)  21/26 (81%) |14/29 (48%)  16/31 (52%)  22/33 (67%)  25/36 (69%)  |
|FIRST INCIDENCE    |     459          621          502          73          |376          255          72           489          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.465N     P<0.001 **   P<0.001 **  |P=0.182      P=0.307      P=0.222      P=0.192      |
|POLY 3             |     P<0.001 **   P=0.483N     P<0.001 **   P<0.001 **  |P=0.017 *    P=0.233      P=0.059      P=0.023 *    |
|POLY 1.5           |     P<0.001 **   P=0.487N     P<0.001 **   P<0.001 **  |P=0.014 *    P=0.214      P=0.054      P=0.019 *    |
|POLY 6             |     P<0.001 **   P=0.482N     P<0.001 **   P<0.001 **  |P=0.024 *    P=0.282      P=0.080      P=0.033 *    |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.544      P=0.004 **   P<0.001 **  |P=0.016 *    P=0.219      P=0.060      P=0.022 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.002 **   P<0.001 **  |P=0.015 *    P=0.212      P=0.062      P=0.021 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   3/48 (6%)    1/49 (2%)   |6/50 (12%)   15/50 (30%)  12/49 (24%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     11.1%        17.0%        7.6%         2.6%        |13.8%        35.7%        28.6%        22.6%        |
|TERMINAL (d)       |     5/39 (13%)   8/39 (21%)   3/27 (11%)   1/26 (4%)   |5/29 (17%)   14/31 (45%)  11/33 (33%)  9/36 (25%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |561          712          723          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117N     P=0.273      P=0.569N     P=0.217N    |P=0.500N     P=0.028 *    P=0.146      P=0.343      |
|POLY 3             |     P=0.057N     P=0.308      P=0.430N     P=0.138N    |P=0.396      P=0.015 *    P=0.076      P=0.213      |
|POLY 1.5           |     P=0.049N*    P=0.297      P=0.406N     P=0.127N    |P=0.384      P=0.017 *    P=0.076      P=0.210      |
|POLY 6             |     P=0.069N     P=0.315      P=0.467N     P=0.150N    |P=0.418      P=0.014 *    P=0.081      P=0.222      |
|LOGISTIC REGRESSION|     P=0.117N     P=0.273      P=0.569N     P=0.217N    |P=0.439      P=0.020 *    P=0.095      P=0.227      |
|COCH-ARM / FISHERS |     P=0.036N*    P=0.277      P=0.381N     P=0.107N    |P=0.372      P=0.024 *    P=0.088      P=0.207      |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    6/50 (12%)   45/48 (94%)  44/49 (90%) |39/50 (78%)  44/50 (88%)  46/49 (94%)  48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     0.0%         12.7%        95.9%        95.2%       |84.3%        92.4%        98.6%        98.8%        |
|TERMINAL (d)       |     0/39 (0%)    4/39 (10%)   27/27 (100%) 25/26 (96%) |26/29 (90%)  30/31 (97%)  33/33 (100%) 36/36 (100%) |
|FIRST INCIDENCE    |     ---          705          430          312         |561          372          408          485          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.020 *    P<0.001 **   P<0.001 **  |P=0.463      P=0.331      P=0.355      P=0.451      |
|POLY 3             |     P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.162      P=0.007 **   P=0.005 **   |
|POLY 1.5           |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.130      P=0.006 **   P=0.005 **   |
|POLY 6             |     P<0.001 **   P=0.019 *    P<0.001 **   P<0.001 **  |P=0.002 **   P=0.246      P=0.012 *    P=0.009 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **  |P=0.003 **   P=0.060      P=0.004 **   P=0.004 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P=0.004 **   P=0.143      P=0.022 *    P=0.007 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    9/49 (18%)   3/48 (6%)   |1/50 (2%)    7/50 (14%)   13/49 (27%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     2.2%         4.2%         21.9%        7.5%        |2.3%         16.2%        29.0%        49.7%        |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    5/27 (19%)   1/26 (4%)   |0/29 (0%)    2/31 (7%)    7/33 (21%)   21/36 (58%)  |
|FIRST INCIDENCE    |     459          621          457          312         |565          534          397          656          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.092      P=0.512      P=0.003 **   P=0.245     |P<0.001 **   P=0.038 *    P=0.002 **   P<0.001 **   |
|POLY 3             |     P=0.109      P=0.514      P=0.004 **   P=0.257     |P<0.001 **   P=0.029 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.126      P=0.509      P=0.005 **   P=0.267     |P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.092      P=0.518      P=0.003 **   P=0.245     |P<0.001 **   P=0.031 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.278      P=0.266      P=0.012 *    P=0.453     |P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.176      P=0.500      P=0.007 **   P=0.293     |P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    7/50 (14%)   16/49 (33%)  21/48 (44%) |6/50 (12%)   27/50 (54%)  42/49 (86%)  44/50 (88%)  |
|POLY-3 ADJUSTED (b)|     2.2%         14.7%        36.2%        50.9%       |13.6%        58.3%        88.7%        90.5%        |
|TERMINAL (d)       |     0/39 (0%)    5/39 (13%)   5/27 (19%)   17/26 (65%) |4/29 (14%)   15/31 (48%)  29/33 (88%)  33/36 (92%)  |
|FIRST INCIDENCE    |     459          621          457          312         |565          372          397          437          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.039 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.033 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.036 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/46 (2%)    2/47 (4%)   |0/48 (0%)    1/50 (2%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         2.1%         2.6%         5.3%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     1/39 (3%)    1/39 (3%)    1/27 (4%)    1/26 (4%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      702         |---          592          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.220      P=0.762      P=0.678      P=0.369     |P=0.561N     P=0.505      (e)          (e)          |
|POLY 3             |     P=0.289      P=0.750N     P=0.726      P=0.442     |P=0.570N     P=0.502      (e)          (e)          |
|POLY 1.5           |     P=0.301      P=0.753N     P=0.734      P=0.452     |P=0.570N     P=0.503      (e)          (e)          |
|POLY 6             |     P=0.276      P=0.747N     P=0.713      P=0.430     |P=0.568N     P=0.503      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.250      P=0.762      P=0.678      P=0.419     |P=0.581N     P=0.563      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.328      P=0.753N     P=0.731      P=0.477     |P=0.566N     P=0.510      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/46 (4%)    0/47 (0%)   |1/48 (2%)    1/50 (2%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         5.0%         0.0%        |2.4%         2.4%         2.3%         2.3%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          707          502          ---         |586          534          537          708          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.639      P=0.505      P=0.230      (e)         |P=0.629N     P=0.753      P=0.748      P=0.752N     |
|POLY 3             |     P=0.609      P=0.510      P=0.210      (e)         |P=0.625N     P=0.761N     P=0.760N     P=0.754N     |
|POLY 1.5           |     P=0.627      P=0.507      P=0.215      (e)         |P=0.627N     P=0.759N     P=0.760      P=0.755N     |
|POLY 6             |     P=0.589      P=0.513      P=0.203      (e)         |P=0.623N     P=0.761N     P=0.757N     P=0.752N     |
|LOGISTIC REGRESSION|     P=0.473N     P=0.502      P=0.197      (e)         |P=0.624      P=0.677N     P=0.699N     P=0.757      |
|COCH-ARM / FISHERS |     P=0.634N     P=0.500      P=0.227      (e)         |P=0.631N     P=0.742N     P=0.747N     P=0.747N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Epithelium                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/46 (9%)    1/47 (2%)   |1/48 (2%)    0/50 (0%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         10.0%        2.6%        |2.4%         0.0%         2.4%         2.3%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    1/27 (4%)    1/26 (4%)   |1/29 (3%)    0/31 (0%)    1/33 (3%)    1/36 (3%)    |
|FIRST INCIDENCE    |     ---          ---          537          729 (T)     |731 (T)      ---          731 (T)      731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.180      (e)          P=0.045 *    P=0.419     |P=0.593      P=0.487N     P=0.733N     P=0.713N     |
|POLY 3             |     P=0.164      (e)          P=0.046 *    P=0.466     |P=0.556      P=0.500N     P=0.761      P=0.752N     |
|POLY 1.5           |     P=0.180      (e)          P=0.048 *    P=0.472     |P=0.551      P=0.499N     P=0.760      P=0.753N     |
|POLY 6             |     P=0.148      (e)          P=0.043 *    P=0.459     |P=0.559      P=0.500N     P=0.758N     P=0.749N     |
|LOGISTIC REGRESSION|     P=0.304      (e)          P=0.060      P=0.419     |P=0.593      (e)          P=0.733N     P=0.713N     |
|COCH-ARM / FISHERS |     P=0.226      (e)          P=0.049 *    P=0.485     |P=0.542      P=0.490N     P=0.747N     P=0.747N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    6/49 (12%)   4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     11.0%        8.4%         14.7%        9.8%        |                                                    |
|TERMINAL (d)       |     3/39 (8%)    2/39 (5%)    3/27 (11%)   2/26 (8%)   |                                                    |
|FIRST INCIDENCE    |     667          611          583          73          |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.435      P=0.470N     P=0.313      P=0.601     |                                                    |
|POLY 3             |     P=0.541      P=0.468N     P=0.427      P=0.568N    |                                                    |
|POLY 1.5           |     P=0.547N     P=0.479N     P=0.453      P=0.543N    |                                                    |
|POLY 6             |     P=0.495      P=0.460N     P=0.389      P=0.599N    |                                                    |
|LOGISTIC REGRESSION|     P=0.369N     P=0.529N     P=0.479      P=0.411N    |                                                    |
|COCH-ARM / FISHERS |     P=0.485N     P=0.500N     P=0.486      P=0.500N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/49 (6%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.5%         0.0%        |                                                    |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    2/27 (7%)    0/26 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          585          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.453      (e)          P=0.076      (e)         |                                                    |
|POLY 3             |     P=0.451      (e)          P=0.099      (e)         |                                                    |
|POLY 1.5           |     P=0.477      (e)          P=0.106      (e)         |                                                    |
|POLY 6             |     P=0.424      (e)          P=0.090      (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.542      (e)          P=0.115      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.538      (e)          P=0.117      (e)         |                                                    |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/43 (2%)    1/43 (2%)    1/36 (3%)    1/37 (3%)   |1/46 (2%)    2/41 (5%)    0/46 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.4%         3.4%         3.3%        |2.5%         5.5%         0.0%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    0/35 (0%)    0/20 (0%)    0/20 (0%)   |0/27 (0%)    0/28 (0%)    0/32 (0%)    0/35 (0%)    |
|FIRST INCIDENCE    |     642          611          704          623         |645          647          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.561      P=0.741N     P=0.704      P=0.730     |P=0.180N     P=0.505      P=0.500N     P=0.485N     |
|POLY 3             |     P=0.530      P=0.752N     P=0.690      P=0.696     |P=0.177N     P=0.460      P=0.502N     P=0.491N     |
|POLY 1.5           |     P=0.546      P=0.754N     P=0.705      P=0.705     |P=0.178N     P=0.458      P=0.503N     P=0.491N     |
|POLY 6             |     P=0.511      P=0.751N     P=0.669      P=0.684     |P=0.174N     P=0.469      P=0.497N     P=0.489N     |
|LOGISTIC REGRESSION|     P=0.613N     P=0.677      P=0.738      P=0.772N    |P=0.177N     P=0.468      P=0.485N     P=0.494N     |
|COCH-ARM / FISHERS |     P=0.584      P=0.753N     P=0.707      P=0.714     |P=0.178N     P=0.456      P=0.500N     P=0.489N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/43 (0%)    0/43 (0%)    0/36 (0%)    0/37 (0%)   |1/46 (2%)    2/41 (5%)    1/46 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.5%         5.6%         2.5%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    0/35 (0%)    0/20 (0%)    0/20 (0%)   |1/27 (4%)    2/28 (7%)    1/32 (3%)    0/35 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      731 (T)      731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.190N     P=0.513      P=0.724N     P=0.448N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.229N     P=0.459      P=0.761      P=0.489N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.231N     P=0.457      P=0.758      P=0.490N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.225N     P=0.467      P=0.755N     P=0.486N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.190N     P=0.513      P=0.724N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.232N     P=0.456      P=0.753N     P=0.489N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   8/48 (17%)   6/49 (12%)   5/50 (10%)  |11/50 (22%)  8/50 (16%)   11/50 (22%)  11/49 (22%)  |
|POLY-3 ADJUSTED (b)|     11.1%        17.5%        14.9%        12.6%       |25.5%        19.1%        26.1%        25.6%        |
|TERMINAL (d)       |     5/39 (13%)   6/38 (16%)   4/27 (15%)   3/26 (12%)  |9/29 (31%)   8/31 (26%)   9/33 (27%)   11/35 (31%)  |
|FIRST INCIDENCE    |     729 (T)      656          618          684         |689          731 (T)      698          731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.368      P=0.271      P=0.273      P=0.390     |P=0.467N     P=0.249N     P=0.472N     P=0.404N     |
|POLY 3             |     P=0.554N     P=0.286      P=0.424      P=0.552     |P=0.446      P=0.327N     P=0.573      P=0.594      |
|POLY 1.5           |     P=0.514N     P=0.273      P=0.451      P=0.576     |P=0.436      P=0.326N     P=0.563      P=0.585      |
|POLY 6             |     P=0.510      P=0.299      P=0.386      P=0.524     |P=0.459      P=0.318N     P=0.596N     P=0.590N     |
|LOGISTIC REGRESSION|     P=0.521      P=0.289      P=0.375      P=0.483     |P=0.500      P=0.292N     P=0.554N     P=0.544N     |
|COCH-ARM / FISHERS |     P=0.433N     P=0.250      P=0.486      P=0.630N    |P=0.419      P=0.306N     P=0.595N     P=0.574      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     4/4 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     3/3 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          707          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    5/46 (11%)   4/45 (9%)   |1/47 (2%)    1/49 (2%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         12.3%        10.6%       |2.4%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    1/31 (3%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          707          537          623         |611          731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.026 *    P=0.243      P=0.027 *    P=0.037 *   |P=0.217N     P=0.756N     P=0.505N     P=0.486N     |
|POLY 3             |     P=0.025 *    P=0.249      P=0.023 *    P=0.041 *   |P=0.229N     P=0.759      P=0.501N     P=0.488N     |
|POLY 1.5           |     P=0.028 *    P=0.245      P=0.023 *    P=0.042 *   |P=0.230N     P=0.760N     P=0.501N     P=0.488N     |
|POLY 6             |     P=0.023 *    P=0.252      P=0.021 *    P=0.039 *   |P=0.229N     P=0.758      P=0.498N     P=0.487N     |
|LOGISTIC REGRESSION|     P=0.060      P=0.249      P=0.028 *    P=0.047 *   |P=0.228N     P=0.750N     P=0.462N     P=0.496N     |
|COCH-ARM / FISHERS |     P=0.037 *    P=0.247      P=0.022 *    P=0.047 *   |P=0.228N     P=0.742N     P=0.495N     P=0.485N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/46 (2%)    1/45 (2%)   |0/47 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.2%         2.6%         2.7%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    1/39 (3%)    0/27 (0%)    0/26 (0%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          681          537          623         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.425      P=0.253      P=0.487      P=0.481     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.430      P=0.249      P=0.472      P=0.465     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.440      P=0.245      P=0.478      P=0.468     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.419      P=0.252      P=0.464      P=0.460     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.547      P=0.235      P=0.473      P=0.515     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.465      P=0.247      P=0.479      P=0.474     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/46 (9%)    2/45 (4%)   |0/47 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         9.9%         5.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/27 (0%)    2/26 (8%)   |0/29 (0%)    0/31 (0%)    0/33 (0%)    0/36 (0%)    |
|FIRST INCIDENCE    |     ---          707          537          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.102      P=0.505      P=0.050      P=0.154     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.102      P=0.510      P=0.047 *    P=0.197     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.110      P=0.507      P=0.048 *    P=0.202     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.092      P=0.513      P=0.044 *    P=0.191     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.182      P=0.502      P=0.058      P=0.154     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.135      P=0.500      P=0.049 *    P=0.222     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         7.2%         2.4%         0.0%         |
|TERMINAL (d)       |                                                        |1/29 (3%)    2/31 (7%)    1/33 (3%)    0/36 (0%)    |
|FIRST INCIDENCE    |                                                        |725          723          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.078N     P=0.521      P=0.463N     P=0.201N     |
|POLY 3             |                                                        |P=0.100N     P=0.488      P=0.509N     P=0.232N     |
|POLY 1.5           |                                                        |P=0.102N     P=0.489      P=0.513N     P=0.234N     |
|POLY 6             |                                                        |P=0.097N     P=0.494      P=0.500N     P=0.228N     |
|LOGISTIC REGRESSION|                                                        |P=0.089N     P=0.502      P=0.477N     P=0.220N     |
|COCH-ARM / FISHERS |                                                        |P=0.105N     P=0.500      P=0.508N     P=0.247N     |
|=================================================================================================================================|
       Date:  02/18/98                           EXPERIMENT: 05197 TEST: 12                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    2/50 (4%)    1/49 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         4.8%         2.4%         6.8%         |
|TERMINAL (d)       |                                                        |2/29 (7%)    1/31 (3%)    1/33 (3%)    3/36 (8%)    |
|FIRST INCIDENCE    |                                                        |731 (T)      712          731 (T)      731 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.485      P=0.676N     P=0.455N     P=0.599      |
|POLY 3             |                                                        |P=0.415      P=0.686      P=0.509N     P=0.511      |
|POLY 1.5           |                                                        |P=0.410      P=0.685      P=0.512N     P=0.506      |
|POLY 6             |                                                        |P=0.421      P=0.691      P=0.500N     P=0.519      |
|LOGISTIC REGRESSION|                                                        |P=0.440      P=0.695N     P=0.455N     P=0.599      |
|COCH-ARM / FISHERS |                                                        |P=0.403      P=0.691N     P=0.508N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      62.5 PPM     125 PPM      250 PPM     |CONTROL      62.5 PPM     125 PPM      250 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    2/49 (4%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|                                                        |4.6%         0.0%         4.7%         13.5%        |
|TERMINAL (d)       |                                                        |1/29 (3%)    0/31 (0%)    1/33 (3%)    5/36 (14%)   |
|FIRST INCIDENCE    |                                                        |572          ---          572          582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.032 *    P=0.240N     P=0.686N     P=0.197      |
|POLY 3             |                                                        |P=0.019 *    P=0.246N     P=0.685      P=0.139      |
|POLY 1.5           |                                                        |P=0.019 *    P=0.244N     P=0.681      P=0.137      |
|POLY 6             |                                                        |P=0.020 *    P=0.244N     P=0.694N     P=0.144      |
|LOGISTIC REGRESSION|                                                        |P=0.019 *    P=0.222N     P=0.686N     P=0.135      |
|COCH-ARM / FISHERS |                                                        |P=0.019 *    P=0.247N     P=0.684      P=0.134      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).