Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/6104

TDMS Study 05200-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                       NITROMETHANE                                     DATE: 04/04/96       
EXPERIMENT: 05200 TEST: 05                                                                                     TIME: 05:46:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-75189                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C61927       
PATHOLOGIST: R. MILLER                       R. RENNE                                                          CAS: 75-52-5         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                       NITROMETHANE                                     DATE: 04/04/96      
EXPERIMENT: 05200 TEST: 05                                                                                     TIME: 05:46:11      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-75189                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C61927      
PATHOLOGIST: R. MILLER                       R. RENNE                                                          CAS: 75-52-5        
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 0    TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      242   411   490   491   504   512   528   537   552   565                 |
 |      569   580   590   592   600   611   611   612   623   626                 |
 |      644   644   660   664   664   670   673   681   684   692                 |
 |      708   719   720   720   725   727   730                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 94 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      292   397   427   439   490   492   515   520   523   524                 |
 |      574   581   586   588   593   601   604   606   607   608                 |
 |      609   616   636   642   646   650   664   665   665   670                 |
 |      677   686   692   714                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 188 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395   471   492   499   509   518   552   560   561   568                 |
 |      580   590   608   611   621   621   624   629   631   638                 |
 |      638   639   643   650   650   650   665   677   678   678                 |
 |      681   684   692   707   720   728                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 375 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      405   428   444   480   495   516   544   551   571   573                 |
 |      588   590   595   607   608   612   617   630   634   636                 |
 |      638   643   650   650   656   660   664   675   681   681                 |
 |      683   688   692   692   698   698   700   700   705   709                 |
 |      719   732                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  96.0  96.0  84.0  70.0  50.0  26.0      |
 |           |                                                                    |
 |           |                                                                    |
 |94 PPM     |   100.0 100.0 100.0  98.0  96.0  92.0  80.0  66.0  42.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 |188 PPM    |   100.0 100.0 100.0 100.0  98.0  96.0  88.0  76.0  46.0  28.0      |
 |           |                                                                    |
 |           |                                                                    |
 |375 PPM    |   100.0 100.0 100.0 100.0  98.0  92.0  86.0  74.0  46.0  16.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      94 PPM       188 PPM      375 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       26.0%        32.0%        28.0%        16.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.378      P=1.000N     P=1.000N     P=0.361  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       610.0        582.3        612.7        622.3    |
 |NATURAL DEATHS (C)      |       (16.6)       (16.1)       (12.6)       (12.7)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       642.0        630.5        646.4        640.0    |
 |(STANDARD ERROR)        |       (14.5)       (14.8)       (11.9)       (12.1)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      454   519   519   539   544   565   573   585   600   604                 |
 |      630   631   631   650   658   681   691   691   713   714                 |
 |      726   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 94 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   435   473   488   495   512   520   551   561   576                 |
 |      579   580   586   588   600   606   621   623   636   662                 |
 |      664   665   667   672   680   691   698   700   720   727                 |
 |      730                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 188 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      432   440   468   491   508   512   513   545   619   638                 |
 |      646   650   657   665   670   686   691   698   705   712                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 375 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      387   425   492   496   550   552   594   597   600   604                 |
 |      604   607   634   636   642   651   660   665   665   670                 |
 |      672   676   684   709   712   720   720                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                   NITROMETHANE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  90.0  80.0  70.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |94 PPM     |   100.0 100.0 100.0 100.0 100.0  94.0  86.0  70.0  56.0  38.0      |
 |           |                                                                    |
 |           |                                                                    |
 |188 PPM    |   100.0 100.0 100.0 100.0 100.0  94.0  84.0  84.0  72.0  60.0      |
 |           |                                                                    |
 |           |                                                                    |
 |375 PPM    |   100.0 100.0 100.0 100.0  96.0  96.0  92.0  78.0  62.0  46.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      94 PPM       188 PPM      375 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%        38.0%        60.0%        46.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.780      P=0.083      P=0.900N     P=0.404  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       620.2        604.3        597.3        615.7    |
 |NATURAL DEATHS (C)      |       (16.4)       (15.4)       (21.6)       (16.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       683.4        653.2        678.7        669.7    |
 |(STANDARD ERROR)        |       (10.7)       (13.0)       (12.8)       (12.2)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                            NITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        94 PPM           = 2
                                                        188 PPM          = 3
                                                        375 PPM          = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  112 +
      |
      |
      | 1                                      1      2                241  4      3
P  96 +                                                                2 1 2424    34113
E     |                                                                      2      421131
R     |                                                                               2  1 211433
C     |                                                                                      1 1313
E  80 +                                                                                    2     1114 3
N     |                                                                                            12 1 33
T     |                                                                                             2 11413
      |                                                                                                22433
S  64 +                                                                                                  11133
U     |                                                                                                 22 141
R     |                                                                                                  2  213  1
V     |                                                                                                      224 11
I  48 +                                                                                                       2  2111
V     |                                                                                                          22411
A     |                                                                                                           2221  11
L     |                                                                                                             22 32
   32 +                                                                                                              443211 2
      |                                                                                                                   1 1
      |                                                                                                               444
      |                                                                                                                 44  4
   16 +                                                                                                                     4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 99 obs hidden.
                                                            NITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        94 PPM           = 2
                                                        188 PPM          = 3
                                                        375 PPM          = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                                                             4     2   1
      |                                                               4    422  1          1
   96 +                                                                    4 2    32  4
      |                                                                           32 23    1 1
      |                                                                              22 3    114
      |                                                                               2 32    1  1
   88 +                                                                                  2 2   4 11   4
      |                                                                                  3 2  32  1 1 44
P     |                                                                                       32 2  1  1  3
E     |                                                                                          2 2   11 3  3
R  80 +                                                                                                 1  1 33
C     |                                                                                                    11
E     |                                                                                            22   4   4 33
N     |                                                                                                     1 13 3
T  72 +                                                                                             2  2    4411 33
      |                                                                                                22    441  3 1
S     |                                                                                                 2 2   4  4  11
U     |                                                                                                              33
R  64 +                                                                                                   2 2        1331
V     |                                                                                                     2    24    33
I     |                                                                                                                 1 1 3
V     |                                                                                                           44
A  56 +                                                                                                          2244     1 1
L     |                                                                                                             4   4
      |                                                                                                           2 2
      |                                                                                                             22  44
   48 +                                                                                                              22
      |                                                                                                                  4  4
      |                                                                                                               2  2
      |                                                                                                                  22
   40 +                                                                                                                   2 2
      |                                                                                                                     2
      |
      |
   32 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 17 obs hidden.