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TDMS Study 05201-05 Pathology Tables

NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11

                                                    2 YEAR CHRONIC FINAL #2




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           21           24           32                                     
    Natural Death                                      1            3            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           25           22           16                                     
    Natural Death                                                   1                                                               
  Other                                                                          1                                                  

  Animals Examined Microscopically                    50           50           49           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (48)         (48)                                   
      Parasite Metazoan                                2 (4%)       3 (6%)       2 (4%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (47)         (47)         (49)                                   
      Parasite Metazoan                                4 (8%)       3 (6%)       3 (6%)       3 (6%)                                
   Intestine Large, Cecum                             (49)         (47)         (46)         (48)                                   
      Parasite Metazoan                                5 (10%)      4 (9%)       8 (17%)      4 (8%)                                
   Intestine Small, Ileum                             (49)         (47)         (46)         (48)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (49)         (49)         (50)                                   
      Angiectasis                                      3 (6%)       2 (4%)       3 (6%)       5 (10%)                               
      Basophilic Focus                                30 (60%)     31 (63%)     34 (69%)     22 (44%)                               
      Clear Cell Focus                                 5 (10%)      6 (12%)      6 (12%)      3 (6%)                                
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                                                       1 (2%)       1 (2%)                                
      Degeneration, Fatty                             13 (26%)      9 (18%)     10 (20%)     17 (34%)                               
      Eosinophilic Focus                               3 (6%)       2 (4%)       4 (8%)       1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       7 (14%)      6 (12%)      4 (8%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                 9 (18%)     13 (27%)      9 (18%)      8 (16%)                               
      Necrosis                                         1 (2%)       1 (2%)                    2 (4%)                                
      Regeneration                                                  1 (2%)                    1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia                           6 (12%)      7 (14%)      6 (12%)      7 (14%)                               
      Centrilobular, Necrosis                          6 (12%)      6 (12%)      8 (16%)      9 (18%)                               
   Mesentery                                          (15)         (8)          (11)         (7)                                    
      Fat, Hemorrhage                                  1 (7%)                                                                       
      Fat, Necrosis                                   13 (87%)      7 (88%)     11 (100%)     6 (86%)                               
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Pharyngeal, Hyperplasia, Squamous                             1 (100%)     1 (100%)                                           

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (49)         (49)         (48)         (50)                                   
      Atrophy                                         10 (20%)     11 (22%)     11 (23%)     11 (22%)                               
      Basophilic Focus                                 4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
   Salivary Glands                                    (49)         (50)         (49)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                                         1 (2%)       1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         5 (10%)      6 (12%)      5 (10%)     12 (24%)                               
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Mineralization                                   2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Necrosis                                         1 (2%)       2 (4%)       3 (6%)       7 (14%)                               
   Tongue                                             (1)          (4)          (1)          (3)                                    
      Hyperplasia, Squamous                                                                   1 (33%)                               
   Tooth                                              (1)                                    (1)                                    
      Degeneration                                                                            1 (100%)                              
      Pulp, Necrosis                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Aorta, Mineralization                                         1 (100%)                                                        
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                  29 (58%)     24 (48%)     23 (47%)     19 (38%)                               
      Artery, Mineralization                                        1 (2%)                                                          
      Atrium, Thrombosis                               3 (6%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (48)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Hyperplasia                                     19 (38%)     22 (44%)     21 (44%)     23 (46%)                               
      Hypertrophy                                      2 (4%)       4 (8%)       6 (13%)      2 (4%)                                
      Necrosis                                         4 (8%)       1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                        5 (10%)      3 (6%)       3 (6%)       8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (48)         (50)                                   
      Hyperplasia                                     12 (24%)      7 (14%)     10 (21%)     14 (28%)                               
   Islets, Pancreatic                                 (49)         (48)         (48)         (50)                                   
      Hyperplasia                                                                2 (4%)                                             
   Parathyroid Gland                                  (46)         (43)         (44)         (46)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (48)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Pars Distalis, Angiectasis                                                 3 (6%)                                             
      Pars Distalis, Hyperplasia                       8 (16%)     10 (20%)      7 (15%)      9 (18%)                               
   Thyroid Gland                                      (49)         (49)         (47)         (48)                                   
      C-Cell, Hyperplasia                             40 (82%)     41 (84%)     35 (74%)     39 (81%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (45)         (46)         (45)                                   
      Hyperplasia                                      1 (2%)       5 (11%)      2 (4%)       1 (2%)                                
      Inflammation, Chronic Active                     2 (5%)       3 (7%)       1 (2%)                                             
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             3 (6%)       5 (10%)      6 (12%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (48)         (48)         (50)                                   
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (4)          (5)          (8)          (11)                                   
      Renal, Ectasia                                                                          1 (9%)                                
      Renal, Hemorrhage                                             1 (20%)      1 (13%)      1 (9%)                                
      Renal, Pigmentation                                                        1 (13%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
   Lymph Node, Mediastinal                            (43)         (37)         (45)         (40)                                   
      Hemorrhage                                                                 1 (2%)       1 (3%)                                
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Accessory Spleen                                                           2 (4%)       1 (2%)                                
      Fibrosis                                         5 (10%)      3 (6%)       3 (6%)       5 (10%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       4 (8%)       2 (4%)       5 (10%)                               
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Metaplasia, Lipocyte                             1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (50)                                   
      Galactocele                                      3 (6%)       2 (4%)       1 (2%)       5 (10%)                               
      Hyperplasia, Atypical                                                                   1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
   Skin                                               (50)         (50)         (48)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Subcutaneous Tissue, Necrosis                                                           1 (2%)                                
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Chronic Active                                                      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Fibrous Osteodystrophy                                        1 (2%)                    1 (2%)                                
      Hyperostosis                                     8 (16%)     14 (28%)     12 (24%)      6 (12%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (49)                                   
      Epiglottis, Metaplasia, Squamous                 1 (2%)                                                                       
   Lung                                               (50)         (50)         (49)         (50)                                   
      Foreign Body                                                                            1 (2%)                                
      Infiltration Cellular, Histiocyte                2 (4%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                    2 (4%)       3 (6%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 9 (18%)     16 (32%)     13 (27%)     12 (24%)                               
      Mediastinum, Inflammation, Granulomatous                                                1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                             1 (2%)                                                                       
   Nose                                               (49)         (50)         (48)         (49)                                   
      Inflammation, Suppurative                        4 (8%)       1 (2%)       5 (10%)     23 (47%)                               
      Thrombosis                                       7 (14%)      3 (6%)       6 (13%)      5 (10%)                               
      Glands, Hyperplasia                                                       24 (50%)     46 (94%)                               
      Lateral Wall, Hyperplasia                                    39 (78%)     48 (100%)    49 (100%)                              
      Lateral Wall, Metaplasia, Squamous                            1 (2%)                   24 (49%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atrophy                                 6 (12%)     44 (92%)     49 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline     43 (88%)     50 (100%)    47 (98%)     48 (98%)                               
      Olfactory Epithelium, Fibrosis                                            16 (33%)     31 (63%)                               
      Olfactory Epithelium, Hyperplasia                                         31 (65%)     41 (84%)                               
      Olfactory Epithelium, Metaplasia                              5 (10%)     37 (77%)     48 (98%)                               
      Respiratory Epithelium, Degeneration, Hyaline   23 (47%)     39 (78%)     45 (94%)      6 (12%)                               
      Respiratory Epithelium, Hyperplasia                          18 (36%)     40 (83%)     49 (100%)                              
      Respiratory Epithelium, Metaplasia, Squamous                               2 (4%)      10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)          (1)                                    
      Cataract                                         1 (100%)                  1 (100%)                                           
      Retina, Atrophy                                  1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          2 (4%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Nephropathy                                     47 (94%)     45 (92%)     47 (96%)     47 (94%)                               
      Renal Tubule, Hyperplasia                                                               2 (4%)                                
   Urinary Bladder                                    (49)         (49)         (49)         (50)                                   
      Transitional Epithelium, Hyperplasia                                       2 (4%)       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           43           31           43                                     
    Natural Death                                      8            2           10            7                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                 7            5            9                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (48)         (49)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (50)         (48)         (47)                                   
      Mineralization                                                             1 (2%)       9 (19%)                               
      Parasite Metazoan                                3 (6%)       4 (8%)       6 (13%)      5 (11%)                               
   Intestine Large, Rectum                            (47)         (50)         (48)         (47)                                   
      Mineralization                                                                          2 (4%)                                
      Parasite Metazoan                                1 (2%)       3 (6%)       4 (8%)       1 (2%)                                
   Intestine Large, Cecum                             (46)         (49)         (44)         (45)                                   
      Parasite Metazoan                                2 (4%)       2 (4%)       8 (18%)      4 (9%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
   Intestine Small, Ileum                             (47)         (49)         (43)         (45)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      6 (12%)      2 (4%)       3 (6%)       4 (8%)                                
      Basophilic Focus                                 9 (18%)     12 (24%)     27 (54%)     31 (62%)                               
      Clear Cell Focus                                 5 (10%)      1 (2%)       4 (8%)                                             
      Cyst                                                                       2 (4%)                                             
      Degeneration, Cystic                            12 (24%)     18 (36%)     12 (24%)      9 (18%)                               
      Degeneration, Fatty                              5 (10%)      9 (18%)      3 (6%)       7 (14%)                               
      Eosinophilic Focus                               4 (8%)       2 (4%)       3 (6%)       4 (8%)                                
      Hepatodiaphragmatic Nodule                                    1 (2%)       4 (8%)       6 (12%)                               
      Mixed Cell Focus                                              1 (2%)       2 (4%)       2 (4%)                                
      Necrosis                                                      2 (4%)                    2 (4%)                                
      Regeneration                                     1 (2%)       3 (6%)       2 (4%)                                             
      Tension Lipidosis                                                          1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Bile Duct, Hyperplasia                          28 (56%)     31 (62%)     30 (60%)     13 (26%)                               
      Centrilobular, Necrosis                         12 (24%)     17 (34%)     15 (30%)      8 (16%)                               
   Mesentery                                          (11)         (13)         (9)          (26)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pigmentation                                                               1 (11%)                                            
      Thrombosis                                                                              1 (4%)                                
      Artery, Inflammation, Chronic Active                                                    3 (12%)                               
      Artery, Mineralization                                        2 (15%)                  22 (85%)                               
      Fat, Hemorrhage                                               2 (15%)      1 (11%)      2 (8%)                                
      Fat, Necrosis                                   10 (91%)      6 (46%)      7 (78%)      4 (15%)                               
   Oral Mucosa                                        (1)          (1)          (1)          (1)                                    
      Gingival, Inflammation, Chronic Active           1 (100%)                                                                     
      Pharyngeal, Hyperplasia                                                    1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy                                         22 (44%)     22 (44%)     23 (46%)     17 (35%)                               
      Basophilic Focus                                 3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Hyperplasia                                      5 (10%)      2 (4%)                    2 (4%)                                
      Artery, Inflammation                                          1 (2%)                    5 (10%)                               
      Artery, Mineralization                                                     1 (2%)       3 (6%)                                
   Salivary Glands                                    (47)         (50)         (49)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)      12 (24%)                               
      Necrosis                                         9 (18%)      6 (12%)     10 (20%)      6 (12%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Mineralization                                   2 (4%)       2 (4%)       3 (6%)      32 (65%)                               
      Necrosis                                         7 (14%)      3 (6%)       4 (8%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (2)          (3)          (31)                                   
      Aorta, Mineralization                            2 (100%)     2 (100%)     2 (67%)     31 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  38 (76%)     32 (64%)     40 (80%)     42 (84%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Artery, Mineralization                           2 (4%)       2 (4%)       2 (4%)      29 (58%)                               
      Atrium, Thrombosis                               3 (6%)       6 (12%)      1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     15 (30%)     19 (38%)     20 (40%)     24 (48%)                               
      Hypertrophy                                      3 (6%)       3 (6%)       1 (2%)       4 (8%)                                
      Necrosis                                                                   2 (4%)       1 (2%)                                
      Vacuolization Cytoplasmic                        4 (8%)       3 (6%)       4 (8%)       8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                     30 (60%)     17 (34%)     24 (48%)     19 (38%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (49)         (45)         (50)         (49)                                   
      Hyperplasia                                      9 (18%)      5 (11%)     12 (24%)     39 (80%)                               
      Necrosis                                                                                1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (48)         (50)                                   
      Mineralization                                   1 (2%)                                                                       
      Pars Distalis, Angiectasis                                                              1 (2%)                                
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       4 (8%)       8 (16%)      3 (6%)      11 (22%)                               
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (49)         (49)         (49)         (47)                                   
      C-Cell, Hyperplasia                             27 (55%)     33 (67%)     30 (61%)     21 (45%)                               
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)       4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      7 (14%)      3 (6%)       5 (10%)                                            
      Inflammation, Chronic Active                     9 (18%)      8 (16%)      3 (6%)       5 (10%)                               
   Seminal Vesicle                                    (49)         (49)         (46)         (47)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                             1 (2%)       3 (6%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)       5 (10%)                               
      Artery, Inflammation, Chronic Active             3 (6%)       1 (2%)       4 (8%)       8 (16%)                               
      Interstitial Cell, Hyperplasia                   4 (8%)       6 (12%)      4 (8%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Necrosis                                                      2 (4%)                                                          
   Lymph Node                                         (10)         (8)          (10)         (12)                                   
      Ectasia                                                                                 1 (8%)                                
      Iliac, Ectasia                                                                          1 (8%)                                
      Renal, Ectasia                                                                          4 (33%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hemorrhage                                1 (10%)                   1 (10%)      3 (25%)                               
   Lymph Node, Mandibular                             (44)         (42)         (48)         (46)                                   
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
   Lymph Node, Mediastinal                            (45)         (47)         (46)         (44)                                   
      Hemorrhage                                                                              2 (5%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 3 (6%)                                 1 (2%)                                
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                        14 (28%)     13 (26%)     10 (20%)     12 (24%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Hemorrhage                                                                              3 (6%)                                
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Necrosis                                         2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Thymus                                             (43)         (40)         (41)         (38)                                   
      Cyst                                                          1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (30)         (25)         (29)         (27)                                   
      Degeneration                                     1 (3%)                    1 (3%)                                             
      Galactocele                                      6 (20%)      2 (8%)       6 (21%)      7 (26%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     2 (4%)                                                          
      Fibrosis, Focal                                                                         1 (2%)                                
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Tail, Hyperkeratosis                             1 (2%)                                                                       
      Tail, Inflammation, Chronic Active               1 (2%)       2 (4%)       6 (12%)     18 (36%)                               
      Tail, Subcutaneous Tissue, Thrombosis                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           2 (4%)       5 (10%)      6 (12%)     34 (68%)                               
      Fracture                                                                                1 (2%)                                
      Hyperostosis                                                  5 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Necrosis                                                      2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)      24 (48%)                               
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                12 (24%)      7 (14%)      5 (10%)      8 (16%)                               
      Artery, Mediastinum, Mineralization              1 (2%)       2 (4%)       2 (4%)      26 (52%)                               
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                                          1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        3 (6%)       6 (12%)     17 (34%)     44 (88%)                               
      Thrombosis                                      10 (20%)     15 (30%)     11 (22%)      2 (4%)                                
      Glands, Hyperplasia                                                       22 (44%)     49 (98%)                               
      Lateral Wall, Hyperplasia                        1 (2%)      49 (98%)     50 (100%)    50 (100%)                              
      Lateral Wall, Metaplasia, Squamous               1 (2%)       1 (2%)       8 (16%)     33 (66%)                               
      Lateral Wall, Necrosis                           1 (2%)                                                                       
      Nasopharyngeal Duct, Inflammation, Acute                                   1 (2%)                                             
      Olfactory Epithelium, Atrophy                    1 (2%)      12 (24%)     47 (94%)     50 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline     42 (84%)     48 (96%)     50 (100%)    47 (94%)                               
      Olfactory Epithelium, Fibrosis                                1 (2%)      26 (52%)     40 (80%)                               
      Olfactory Epithelium, Hyperplasia                             1 (2%)      42 (84%)     40 (80%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)       8 (16%)     37 (74%)     49 (98%)                               
      Respiratory Epithelium, Degeneration, Hyaline   12 (24%)     14 (28%)     45 (90%)      3 (6%)                                
      Respiratory Epithelium, Hyperplasia                          26 (52%)     50 (100%)    50 (100%)                              
      Respiratory Epithelium, Metaplasia, Squamous                               3 (6%)      26 (52%)                               
   Trachea                                            (49)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)          (1)          (3)                                    
      Cataract                                                      1 (33%)      1 (100%)     1 (33%)                               
      Inflammation, Chronic Active                                  2 (67%)                   1 (33%)                               
      Retina, Atrophy                                               1 (33%)                   1 (33%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Harderian Gland                                                 (1)                       (1)                                    
      Hyperplasia                                                                             1 (100%)                              
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       3 (6%)                    4 (8%)                                
      Hydronephrosis                                                             2 (4%)                                             
      Hyperplasia, Oncocytic                                                                  1 (2%)                                
      Infarct                                          1 (2%)       2 (4%)                    1 (2%)                                
      Mineralization                                   2 (4%)       2 (4%)       2 (4%)      28 (56%)                               
      Nephropathy                                     50 (100%)    49 (98%)     50 (100%)    50 (100%)                              
      STROMAL HYPERPLASIA                                                        1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        5 (10%)      5 (10%)      2 (4%)       6 (12%)                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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