Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/12022

TDMS Study 05201-05 Pathology Tables

NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11

                                                    2 YEAR CHRONIC FINAL #2




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           21           24           32                                     
    Natural Death                                      1            3            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           25           22           16                                     
    Natural Death                                                   1                                                               
  Other                                                                          1                                                  

  Animals Examined Microscopically                    50           50           49           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (48)         (48)                                   
      Parasite Metazoan                                2 (4%)       3 (6%)       2 (4%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (47)         (47)         (49)                                   
      Parasite Metazoan                                4 (8%)       3 (6%)       3 (6%)       3 (6%)                                
   Intestine Large, Cecum                             (49)         (47)         (46)         (48)                                   
      Parasite Metazoan                                5 (10%)      4 (9%)       8 (17%)      4 (8%)                                
   Intestine Small, Ileum                             (49)         (47)         (46)         (48)                                   
      Parasite Metazoan                                1 (2%)                                                                       
   Liver                                              (50)         (49)         (49)         (50)                                   
      Angiectasis                                      3 (6%)       2 (4%)       3 (6%)       5 (10%)                               
      Basophilic Focus                                30 (60%)     31 (63%)     34 (69%)     22 (44%)                               
      Clear Cell Focus                                 5 (10%)      6 (12%)      6 (12%)      3 (6%)                                
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                                                       1 (2%)       1 (2%)                                
      Degeneration, Fatty                             13 (26%)      9 (18%)     10 (20%)     17 (34%)                               
      Eosinophilic Focus                               3 (6%)       2 (4%)       4 (8%)       1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       4 (8%)       7 (14%)      6 (12%)      4 (8%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mixed Cell Focus                                 9 (18%)     13 (27%)      9 (18%)      8 (16%)                               
      Necrosis                                         1 (2%)       1 (2%)                    2 (4%)                                
      Regeneration                                                  1 (2%)                    1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia                           6 (12%)      7 (14%)      6 (12%)      7 (14%)                               
      Centrilobular, Necrosis                          6 (12%)      6 (12%)      8 (16%)      9 (18%)                               
   Mesentery                                          (15)         (8)          (11)         (7)                                    
      Fat, Hemorrhage                                  1 (7%)                                                                       
      Fat, Necrosis                                   13 (87%)      7 (88%)     11 (100%)     6 (86%)                               
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Pharyngeal, Hyperplasia, Squamous                             1 (100%)     1 (100%)                                           

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (49)         (49)         (48)         (50)                                   
      Atrophy                                         10 (20%)     11 (22%)     11 (23%)     11 (22%)                               
      Basophilic Focus                                 4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Metaplasia, Hepatocyte                                                                  1 (2%)                                
   Salivary Glands                                    (49)         (50)         (49)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Hyperplasia, Squamous                                         1 (2%)       1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Necrosis                                         5 (10%)      6 (12%)      5 (10%)     12 (24%)                               
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Mineralization                                   2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Necrosis                                         1 (2%)       2 (4%)       3 (6%)       7 (14%)                               
   Tongue                                             (1)          (4)          (1)          (3)                                    
      Hyperplasia, Squamous                                                                   1 (33%)                               
   Tooth                                              (1)                                    (1)                                    
      Degeneration                                                                            1 (100%)                              
      Pulp, Necrosis                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Aorta, Mineralization                                         1 (100%)                                                        
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                  29 (58%)     24 (48%)     23 (47%)     19 (38%)                               
      Artery, Mineralization                                        1 (2%)                                                          
      Atrium, Thrombosis                               3 (6%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (48)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Hyperplasia                                     19 (38%)     22 (44%)     21 (44%)     23 (46%)                               
      Hypertrophy                                      2 (4%)       4 (8%)       6 (13%)      2 (4%)                                
      Necrosis                                         4 (8%)       1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic                        5 (10%)      3 (6%)       3 (6%)       8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (48)         (50)                                   
      Hyperplasia                                     12 (24%)      7 (14%)     10 (21%)     14 (28%)                               
   Islets, Pancreatic                                 (49)         (48)         (48)         (50)                                   
      Hyperplasia                                                                2 (4%)                                             
   Parathyroid Gland                                  (46)         (43)         (44)         (46)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (48)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Pars Distalis, Angiectasis                                                 3 (6%)                                             
      Pars Distalis, Hyperplasia                       8 (16%)     10 (20%)      7 (15%)      9 (18%)                               
   Thyroid Gland                                      (49)         (49)         (47)         (48)                                   
      C-Cell, Hyperplasia                             40 (82%)     41 (84%)     35 (74%)     39 (81%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (45)         (46)         (45)                                   
      Hyperplasia                                      1 (2%)       5 (11%)      2 (4%)       1 (2%)                                
      Inflammation, Chronic Active                     2 (5%)       3 (7%)       1 (2%)                                             
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Cyst                                             3 (6%)       5 (10%)      6 (12%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (48)         (48)         (50)                                   
      Hyperplasia, Histiocytic                         2 (4%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (4)          (5)          (8)          (11)                                   
      Renal, Ectasia                                                                          1 (9%)                                
      Renal, Hemorrhage                                             1 (20%)      1 (13%)      1 (9%)                                
      Renal, Pigmentation                                                        1 (13%)                                            
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
   Lymph Node, Mediastinal                            (43)         (37)         (45)         (40)                                   
      Hemorrhage                                                                 1 (2%)       1 (3%)                                
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Accessory Spleen                                                           2 (4%)       1 (2%)                                
      Fibrosis                                         5 (10%)      3 (6%)       3 (6%)       5 (10%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       4 (8%)       2 (4%)       5 (10%)                               
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                 1 (2%)                                
      Metaplasia, Lipocyte                             1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (50)                                   
      Galactocele                                      3 (6%)       2 (4%)       1 (2%)       5 (10%)                               
      Hyperplasia, Atypical                                                                   1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
   Skin                                               (50)         (50)         (48)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Subcutaneous Tissue, Necrosis                                                           1 (2%)                                
      Tail, Hyperkeratosis                                                                    1 (2%)                                
      Tail, Inflammation, Chronic Active                                                      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Fibrous Osteodystrophy                                        1 (2%)                    1 (2%)                                
      Hyperostosis                                     8 (16%)     14 (28%)     12 (24%)      6 (12%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (49)                                   
      Epiglottis, Metaplasia, Squamous                 1 (2%)                                                                       
   Lung                                               (50)         (50)         (49)         (50)                                   
      Foreign Body                                                                            1 (2%)                                
      Infiltration Cellular, Histiocyte                2 (4%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                    2 (4%)       3 (6%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 9 (18%)     16 (32%)     13 (27%)     12 (24%)                               
      Mediastinum, Inflammation, Granulomatous                                                1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                             1 (2%)                                                                       
   Nose                                               (49)         (50)         (48)         (49)                                   
      Inflammation, Suppurative                        4 (8%)       1 (2%)       5 (10%)     23 (47%)                               
      Thrombosis                                       7 (14%)      3 (6%)       6 (13%)      5 (10%)                               
      Glands, Hyperplasia                                                       24 (50%)     46 (94%)                               
      Lateral Wall, Hyperplasia                                    39 (78%)     48 (100%)    49 (100%)                              
      Lateral Wall, Metaplasia, Squamous                            1 (2%)                   24 (49%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atrophy                                 6 (12%)     44 (92%)     49 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline     43 (88%)     50 (100%)    47 (98%)     48 (98%)                               
      Olfactory Epithelium, Fibrosis                                            16 (33%)     31 (63%)                               
      Olfactory Epithelium, Hyperplasia                                         31 (65%)     41 (84%)                               
      Olfactory Epithelium, Metaplasia                              5 (10%)     37 (77%)     48 (98%)                               
      Respiratory Epithelium, Degeneration, Hyaline   23 (47%)     39 (78%)     45 (94%)      6 (12%)                               
      Respiratory Epithelium, Hyperplasia                          18 (36%)     40 (83%)     49 (100%)                              
      Respiratory Epithelium, Metaplasia, Squamous                               2 (4%)      10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                       (1)          (1)                                    
      Cataract                                         1 (100%)                  1 (100%)                                           
      Retina, Atrophy                                  1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          2 (4%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Nephropathy                                     47 (94%)     45 (92%)     47 (96%)     47 (94%)                               
      Renal Tubule, Hyperplasia                                                               2 (4%)                                
   Urinary Bladder                                    (49)         (49)         (49)         (50)                                   
      Transitional Epithelium, Hyperplasia                                       2 (4%)       1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           43           31           43                                     
    Natural Death                                      8            2           10            7                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                 7            5            9                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (48)         (49)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (50)         (48)         (47)                                   
      Mineralization                                                             1 (2%)       9 (19%)                               
      Parasite Metazoan                                3 (6%)       4 (8%)       6 (13%)      5 (11%)                               
   Intestine Large, Rectum                            (47)         (50)         (48)         (47)                                   
      Mineralization                                                                          2 (4%)                                
      Parasite Metazoan                                1 (2%)       3 (6%)       4 (8%)       1 (2%)                                
   Intestine Large, Cecum                             (46)         (49)         (44)         (45)                                   
      Parasite Metazoan                                2 (4%)       2 (4%)       8 (18%)      4 (9%)                                
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
   Intestine Small, Ileum                             (47)         (49)         (43)         (45)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      6 (12%)      2 (4%)       3 (6%)       4 (8%)                                
      Basophilic Focus                                 9 (18%)     12 (24%)     27 (54%)     31 (62%)                               
      Clear Cell Focus                                 5 (10%)      1 (2%)       4 (8%)                                             
      Cyst                                                                       2 (4%)                                             
      Degeneration, Cystic                            12 (24%)     18 (36%)     12 (24%)      9 (18%)                               
      Degeneration, Fatty                              5 (10%)      9 (18%)      3 (6%)       7 (14%)                               
      Eosinophilic Focus                               4 (8%)       2 (4%)       3 (6%)       4 (8%)                                
      Hepatodiaphragmatic Nodule                                    1 (2%)       4 (8%)       6 (12%)                               
      Mixed Cell Focus                                              1 (2%)       2 (4%)       2 (4%)                                
      Necrosis                                                      2 (4%)                    2 (4%)                                
      Regeneration                                     1 (2%)       3 (6%)       2 (4%)                                             
      Tension Lipidosis                                                          1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Bile Duct, Hyperplasia                          28 (56%)     31 (62%)     30 (60%)     13 (26%)                               
      Centrilobular, Necrosis                         12 (24%)     17 (34%)     15 (30%)      8 (16%)                               
   Mesentery                                          (11)         (13)         (9)          (26)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pigmentation                                                               1 (11%)                                            
      Thrombosis                                                                              1 (4%)                                
      Artery, Inflammation, Chronic Active                                                    3 (12%)                               
      Artery, Mineralization                                        2 (15%)                  22 (85%)                               
      Fat, Hemorrhage                                               2 (15%)      1 (11%)      2 (8%)                                
      Fat, Necrosis                                   10 (91%)      6 (46%)      7 (78%)      4 (15%)                               
   Oral Mucosa                                        (1)          (1)          (1)          (1)                                    
      Gingival, Inflammation, Chronic Active           1 (100%)                                                                     
      Pharyngeal, Hyperplasia                                                    1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Atrophy                                         22 (44%)     22 (44%)     23 (46%)     17 (35%)                               
      Basophilic Focus                                 3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Hyperplasia                                      5 (10%)      2 (4%)                    2 (4%)                                
      Artery, Inflammation                                          1 (2%)                    5 (10%)                               
      Artery, Mineralization                                                     1 (2%)       3 (6%)                                
   Salivary Glands                                    (47)         (50)         (49)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)      12 (24%)                               
      Necrosis                                         9 (18%)      6 (12%)     10 (20%)      6 (12%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Mineralization                                   2 (4%)       2 (4%)       3 (6%)      32 (65%)                               
      Necrosis                                         7 (14%)      3 (6%)       4 (8%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (2)          (3)          (31)                                   
      Aorta, Mineralization                            2 (100%)     2 (100%)     2 (67%)     31 (100%)                              
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  38 (76%)     32 (64%)     40 (80%)     42 (84%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Artery, Mineralization                           2 (4%)       2 (4%)       2 (4%)      29 (58%)                               
      Atrium, Thrombosis                               3 (6%)       6 (12%)      1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     15 (30%)     19 (38%)     20 (40%)     24 (48%)                               
      Hypertrophy                                      3 (6%)       3 (6%)       1 (2%)       4 (8%)                                
      Necrosis                                                                   2 (4%)       1 (2%)                                
      Vacuolization Cytoplasmic                        4 (8%)       3 (6%)       4 (8%)       8 (16%)                               
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                     30 (60%)     17 (34%)     24 (48%)     19 (38%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (49)         (45)         (50)         (49)                                   
      Hyperplasia                                      9 (18%)      5 (11%)     12 (24%)     39 (80%)                               
      Necrosis                                                                                1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (48)         (50)                                   
      Mineralization                                   1 (2%)                                                                       
      Pars Distalis, Angiectasis                                                              1 (2%)                                
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       4 (8%)       8 (16%)      3 (6%)      11 (22%)                               
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (49)         (49)         (49)         (47)                                   
      C-Cell, Hyperplasia                             27 (55%)     33 (67%)     30 (61%)     21 (45%)                               
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)       4 (8%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      7 (14%)      3 (6%)       5 (10%)                                            
      Inflammation, Chronic Active                     9 (18%)      8 (16%)      3 (6%)       5 (10%)                               
   Seminal Vesicle                                    (49)         (49)         (46)         (47)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                             1 (2%)       3 (6%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)       5 (10%)                               
      Artery, Inflammation, Chronic Active             3 (6%)       1 (2%)       4 (8%)       8 (16%)                               
      Interstitial Cell, Hyperplasia                   4 (8%)       6 (12%)      4 (8%)       7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Necrosis                                                      2 (4%)                                                          
   Lymph Node                                         (10)         (8)          (10)         (12)                                   
      Ectasia                                                                                 1 (8%)                                
      Iliac, Ectasia                                                                          1 (8%)                                
      Renal, Ectasia                                                                          4 (33%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hemorrhage                                1 (10%)                   1 (10%)      3 (25%)                               
   Lymph Node, Mandibular                             (44)         (42)         (48)         (46)                                   
      Infiltration Cellular, Plasma Cell               1 (2%)       1 (2%)                                                          
   Lymph Node, Mediastinal                            (45)         (47)         (46)         (44)                                   
      Hemorrhage                                                                              2 (5%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Accessory Spleen                                 3 (6%)                                 1 (2%)                                
      Angiectasis                                                                1 (2%)                                             
      Fibrosis                                        14 (28%)     13 (26%)     10 (20%)     12 (24%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)       2 (4%)       4 (8%)                                
      Hemorrhage                                                                              3 (6%)                                
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Necrosis                                         2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Thymus                                             (43)         (40)         (41)         (38)                                   
      Cyst                                                          1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (30)         (25)         (29)         (27)                                   
      Degeneration                                     1 (3%)                    1 (3%)                                             
      Galactocele                                      6 (20%)      2 (8%)       6 (21%)      7 (26%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     2 (4%)                                                          
      Fibrosis, Focal                                                                         1 (2%)                                
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Tail, Hyperkeratosis                             1 (2%)                                                                       
      Tail, Inflammation, Chronic Active               1 (2%)       2 (4%)       6 (12%)     18 (36%)                               
      Tail, Subcutaneous Tissue, Thrombosis                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           2 (4%)       5 (10%)      6 (12%)     34 (68%)                               
      Fracture                                                                                1 (2%)                                
      Hyperostosis                                                  5 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Necrosis                                                      2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                 1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)                                                          
      Mineralization                                   1 (2%)       2 (4%)       2 (4%)      24 (48%)                               
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                12 (24%)      7 (14%)      5 (10%)      8 (16%)                               
      Artery, Mediastinum, Mineralization              1 (2%)       2 (4%)       2 (4%)      26 (52%)                               
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                                          1 (2%)                                                          
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        3 (6%)       6 (12%)     17 (34%)     44 (88%)                               
      Thrombosis                                      10 (20%)     15 (30%)     11 (22%)      2 (4%)                                
      Glands, Hyperplasia                                                       22 (44%)     49 (98%)                               
      Lateral Wall, Hyperplasia                        1 (2%)      49 (98%)     50 (100%)    50 (100%)                              
      Lateral Wall, Metaplasia, Squamous               1 (2%)       1 (2%)       8 (16%)     33 (66%)                               
      Lateral Wall, Necrosis                           1 (2%)                                                                       
      Nasopharyngeal Duct, Inflammation, Acute                                   1 (2%)                                             
      Olfactory Epithelium, Atrophy                    1 (2%)      12 (24%)     47 (94%)     50 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline     42 (84%)     48 (96%)     50 (100%)    47 (94%)                               
      Olfactory Epithelium, Fibrosis                                1 (2%)      26 (52%)     40 (80%)                               
      Olfactory Epithelium, Hyperplasia                             1 (2%)      42 (84%)     40 (80%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)       8 (16%)     37 (74%)     49 (98%)                               
      Respiratory Epithelium, Degeneration, Hyaline   12 (24%)     14 (28%)     45 (90%)      3 (6%)                                
      Respiratory Epithelium, Hyperplasia                          26 (52%)     50 (100%)    50 (100%)                              
      Respiratory Epithelium, Metaplasia, Squamous                               3 (6%)      26 (52%)                               
   Trachea                                            (49)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)          (1)          (3)                                    
      Cataract                                                      1 (33%)      1 (100%)     1 (33%)                               
      Inflammation, Chronic Active                                  2 (67%)                   1 (33%)                               
      Retina, Atrophy                                               1 (33%)                   1 (33%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05201-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:07:11  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Harderian Gland                                                 (1)                       (1)                                    
      Hyperplasia                                                                             1 (100%)                              
      Inflammation, Chronic Active                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       3 (6%)                    4 (8%)                                
      Hydronephrosis                                                             2 (4%)                                             
      Hyperplasia, Oncocytic                                                                  1 (2%)                                
      Infarct                                          1 (2%)       2 (4%)                    1 (2%)                                
      Mineralization                                   2 (4%)       2 (4%)       2 (4%)      28 (56%)                               
      Nephropathy                                     50 (100%)    49 (98%)     50 (100%)    50 (100%)                              
      STROMAL HYPERPLASIA                                                        1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        5 (10%)      5 (10%)      2 (4%)       6 (12%)                               
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------