TDMS Study 05201-05 Pathology Tables
NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Tongue | | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | M + + + + + + + + M + M + + + + + M + + + + + + +| Adenoma | X | Carcinoma | X | Bilateral, Adenoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X | Polyp Stromal | X X | Polyp Stromal, Multiple | X | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Lymph Node | +| Pancreatic, Leukemia Mononuclear | X| |__________________________________________________________________________| Lymph Node, Bronchial | + + M M + + M + + + + + + + + + + M + M M + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + M M| Leukemia Mononuclear | X X X X X | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Leukemia Mononuclear | X X X X X X X X X X| Sarcoma | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 4| 4| 7| 7| 7| 7| DAY ON TEST | 3| 3| 8| 9| 3| 7| 7| 3| 1| 2| 3| 0| 3| 3| 3| 8| 3| 2| 3| 7| 7| 3| 3| 3| 0| | 5| 1| 1| 3| 5| 0| 3| 5| 6| 1| 5| 7| 5| 5| 5| 1| 5| 7| 5| 8| 7| 6| 6| 6| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + I + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 15 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Tongue | + | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X| 2 | Leukemia Mononuclear | X X X X X X X X | 14 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 10 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X | 4 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + M + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 10 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 38 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X X X X X | 7 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + M| 44 | Adenoma | X X | 3 | Carcinoma | X X | 3 | Bilateral, Adenoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X X | 3 | Polyp Stromal | X X X | 5 | Polyp Stromal, Multiple | | 1 | Schwannoma Malignant | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node | + + + | 4 | Pancreatic, Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymph Node, Bronchial | + M + + + + M + + + + + M + M + M + M + + + + M +| 37 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | X X X X X X | 9 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + M + + M + + + + + + + + + + M +| 46 | Leukemia Mononuclear | X X X X X X X X | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 16 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + + M + + + + + + + + M + + + M + + + +| 43 | Leukemia Mononuclear | X X X X X X | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + M +| 47 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Carcinoma | X X X| 7 | Carcinoma, Multiple | X | 2 | Fibroadenoma | X X X X X X X X X X| 17 | Fibroadenoma, Multiple | X | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X| 1 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 19 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 7| 6| 6| 4| 0| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 0| 6| 3| 5| 0| 5| 9| 3| 0| 7| 9| 3| 3| 3| 0| 0| 3| 3| 3| 3| 3| 3| 3| | | 6| 6| 9| 1| 6| 2| 9| 6| 8| 6| 7| 3| 9| 6| 6| 6| 7| 4| 6| 6| 6| 6| 6| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Mesentery | + + | Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Tongue | + + | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X X| Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + A + + + M + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + M M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + M + + + +| Adenoma | X X | Leukemia Mononuclear | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Polyp Stromal | X X X | Schwannoma Malignant | | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node | + + | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M M + + M M + + + M + M M + + M + + M M + + M + +| Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + M M M + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | M + + M M M + + + + + + M + + M + + + + + + + + M| Carcinoma, Metastatic, Kidney | X | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M M + + M + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 6| 4| 6| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 3| 7| 3| 7| 6| 7| 5| 3| 9| 8| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| | 7| 5| 5| 1| 5| 9| 9| 7| 1| 5| 7| 1| 5| 5| 2| 6| 8| 6| 7| 3| 6| 6| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Leukemia Mononuclear | X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Renal Tubule, Carcinoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + I + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Transitional Epithelium, Carcinoma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Mesentery | + + + + + + | 8 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | X X X | 4 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Tongue | + + | 4 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 11 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 11 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X | 5 | Bilateral, Pheochromocytoma Benign | X| 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Carcinoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Parathyroid Gland | + + + + M + + + + + + + + M M + + + M + + + + + +| 43 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 5 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 35 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X | 5 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + M + + + + + + + + + M| 45 | Adenoma | | 2 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | X | 1 | Leukemia Mononuclear | X X X X | 6 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 4 | Polyp Stromal | X X X X X X | 9 | Schwannoma Malignant | X | 1 | |__________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X| 11 | |__________________________________________________________________________|____________| Lymph Node | + + + | 5 | Pancreatic, Leukemia Mononuclear | X | 2 | Renal, Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + M M M M + + + + M + + + + + M M M + M + + + +| 30 | Leukemia Mononuclear | X X X X X X X X X X| 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X X X X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X| 17 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + M + + + + + + M M + + + + M + + + + M + + +| 37 | Carcinoma, Metastatic, Kidney | | 1 | Leukemia Mononuclear | X X X X X X X X X X X| 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X| 19 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + M + + + + + + + + + + + + + M +| 44 | Leukemia Mononuclear | X X X X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Carcinoma | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | X X X X X X X X| 17 | Fibroadenoma, Multiple | X X X X X | 7 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mammary Gland | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 18 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 7 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 3| 1| 4| 7| 2| 3| 3| 3| 0| 2| 3| 3| 3| 5| 3| 3| 2| 0| 3| | | 6| 3| 6| 6| 6| 0| 6| 6| 7| 6| 8| 6| 6| 6| 6| 8| 6| 6| 6| 1| 6| 5| 1| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X| 13 | Renal Tubule, Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | Transitional Epithelium, Carcinoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X| 19 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + M M + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| Fibroma | | Leiomyosarcoma | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A + +| Adenocarcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Osteosarcoma, Metastatic, Bone | X X | |__________________________________________________________________________| Mesentery | + + + + + + | Leukemia Mononuclear | X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X X X X X X X| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X X X X X X X| Pheochromocytoma Benign | | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + M + M + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + A + +| C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + M + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, | | Intestine Large, Rectum | X | Leukemia Mononuclear | X X | Polyp Stromal | X X | |__________________________________________________________________________| Vagina | + + | Leiomyosarcoma, Metastatic, | | Intestine Large, Rectum | X | Polyp | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + +| Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X X| Renal, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M + + + + + M M + + + + + + + + + M| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + M + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + M + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + I +| Leukemia Mononuclear | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 5| 5| 6| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 3| 2| 2| 3| 3| 2| 5| 0| 3| 1| 1| 5| 3| 4| 4| 7| 2| 3| | 5| 9| 5| 5| 5| 9| 3| 5| 7| 3| 5| 5| 8| 2| 0| 5| 5| 8| 8| 6| 7| 7| 0| 2| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X X X X X| Osteosarcoma, Metastatic, Bone | X X | Mediastinum, Osteosarcoma, | | Metastatic, Bone | X | |__________________________________________________________________________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Lateral Wall, Adenoma | X | |__________________________________________________________________________| Trachea | + + + + + + A + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Transitional Epithelium, Carcinoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma, Metastatic, | | Intestine Large, Rectum | X | Leukemia Mononuclear | X X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + + M + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I| 47 | Fibroma | X | 1 | Leiomyosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Adenocarcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| 46 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 18 | Osteosarcoma, Metastatic, Bone | | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 11 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 5 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X | 13 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X | 13 | Pheochromocytoma Benign | X X | 2 | Bilateral, Pheochromocytoma Benign | X | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X X | 3 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + +| 44 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X | 10 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 34 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | C-Cell, Adenoma | X X | 6 | C-Cell, Carcinoma | X X | 2 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + +| 46 | Adenoma | X | 2 | Carcinoma | X | 2 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Granulosa Cell Tumor Benign | X | 1 | Leukemia Mononuclear | X X X X X | 7 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leiomyosarcoma, Metastatic, | | | Intestine Large, Rectum | | 1 | Leukemia Mononuclear | X X X | 5 | Polyp Stromal | X X X X | 6 | |__________________________________________________________________________|____________| Vagina | + | 3 | Leiomyosarcoma, Metastatic, | | | Intestine Large, Rectum | | 1 | Polyp | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node | + | 8 | Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X | 4 | Renal, Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + M + + + + + + + + + M + + + M + + + M| 40 | Leukemia Mononuclear | X X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + M + + + +| 46 | Leukemia Mononuclear | X X X X X X | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 17 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + + + M + + + + + +| 45 | Leukemia Mononuclear | X X X X X X | 13 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 18 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Thymus | + M + + + + + + + M + + + + + + + + + + + M + +| 44 | Leukemia Mononuclear | X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma | X | 2 | Fibroadenoma | X X X X X X X X | 19 | Fibroadenoma, Multiple | X X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | | 1 | Subcutaneous Tissue, Fibroma | X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Osteosarcoma | | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X X X X X X | 18 | Osteosarcoma, Metastatic, Bone | | 2 | Mediastinum, Osteosarcoma, | | | Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 4 | Lateral Wall, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 5| | DAY ON TEST | 9| 0| 9| 3| 4| 3| 3| 9| 3| 3| 8| 3| 3| 7| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 9| | | 4| 6| 3| 6| 6| 6| 6| 4| 2| 6| 9| 6| 6| 9| 9| 9| 6| 6| 6| 6| 1| 6| 6| 6| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 13 | Transitional Epithelium, Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leiomyosarcoma, Metastatic, | | | Intestine Large, Rectum | | 1 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 18 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + | Leukemia Mononuclear | X | Sarcoma Stromal, Metastatic, Uterus | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Tongue | + + | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Adenoma | X | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + M + M + + +| Adenoma | X X X X X | Carcinoma | | Bilateral, Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Sertoli Cell Tumor Benign | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Lymph Node | + + + + + | Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M + M + + + + + + + M M M M + M M + M M M + +| Histiocytic Sarcoma | X | __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + M M + M + + + + + + + + + + + + + M + + M + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + M M + + + + + + + + + M + + + + M + + + + + M| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + + M + + + + + + + + + + M + + + + M + + + + + M| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X | Fibroadenoma, Multiple | X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| DAY ON TEST | 3| 1| 3| 3| 7| 0| 3| 3| 3| 3| 1| 1| 1| 1| 8| 3| 3| 1| 2| 6| 4| 3| 3| 3| 3| | 5| 5| 3| 5| 0| 7| 5| 8| 5| 5| 8| 2| 2| 8| 6| 5| 5| 1| 5| 5| 2| 5| 6| 6| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + A + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + A + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Respiratory Epithelium, Adenoma | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X| Renal Tubule, Adenoma | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 29 | |__________________________________________________________________________|____________| Mesentery | + + + | 7 | Leukemia Mononuclear | | 1 | Sarcoma Stromal, Metastatic, Uterus | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | Leukemia Mononuclear | X X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Tongue | + | 3 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 16 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 15 | Pheochromocytoma Benign | X | 5 | Bilateral, Pheochromocytoma Benign | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + M + + + + M + + + + + + + +| 46 | Adenoma | | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 14 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| 35 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | | 5 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 45 | Adenoma | X X | 7 | Carcinoma | X | 1 | Bilateral, Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 8 | Sertoli Cell Tumor Benign | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | Polyp Stromal | X X | 2 | Sarcoma Stromal | X | 2 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X | 15 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + | 11 | Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X X | 4 | Renal, Leukemia Mononuclear | X X X X | 7 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M + M + + M M + + M M + + M + M M + M M +| 25 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + M M + +| 42 | Leukemia Mononuclear | X X X X X X X X X X X | 18 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + M + M + + + + + M + M + + + M + + + +| 40 | Leukemia Mononuclear | X X X X X X X X X X X X | 20 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 29 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + M + + + M + M| 43 | Leukemia Mononuclear | X X X X X X X X | 13 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X | 14 | Fibroadenoma, Multiple | X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 9 | Respiratory Epithelium, Adenoma | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 5| 5| 4| 5| 7| 6| 4| 7| 3| 6| 6| 6| 6| 6| 7| 7| 4| 6| 5| 7| 6| 5| 7| 7| 6| | DAY ON TEST | 9| 9| 9| 8| 3| 1| 2| 3| 0| 9| 8| 3| 2| 3| 3| 3| 7| 7| 6| 2| 3| 2| 0| 3| 5| | | 7| 9| 7| 1| 6| 6| 9| 6| 2| 3| 9| 9| 1| 8| 6| 6| 8| 1| 0| 1| 2| 6| 6| 6| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X | 22 | Renal Tubule, Adenoma | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 29 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + A + + + I + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + + + + + A + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + M + +| Leukemia Mononuclear | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Adenoma | | Carcinoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node | + + + + + +| Leukemia Mononuclear | X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X X X X| Renal, Leukemia Mononuclear | X X| |__________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + M M + M M + + M + M + + + + + + + M| Leukemia Mononuclear | X X X X X X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + M + M M + + + + + + + M + +| __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M M + M + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thymus | + M + + + + + + + + + M + + M + + + + + + + + M +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + M + M M M + M M + M M M + + + + M M M + M| Carcinoma, Multiple | | Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X| Keratoacanthoma | X | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Schwannoma | | Malignant | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 5| 5| 5| 6| 5| 5| 3| 6| 3| 6| 7| 5| 6| 3| 6| 7| 6| 6| 4| 6| 6| 5| 6| DAY ON TEST | 8| 3| 0| 7| 9| 4| 3| 7| 8| 0| 5| 6| 1| 6| 7| 3| 6| 1| 2| 9| 6| 1| 9| 2| 9| | 4| 5| 7| 4| 9| 8| 2| 8| 2| 6| 1| 5| 7| 1| 9| 3| 4| 5| 4| 6| 9| 7| 6| 5| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X| Meningioma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + A + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X | 29 | |__________________________________________________________________________|____________| Mesentery | + + + | 11 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 7 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 22 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 22 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X | 11 | Bilateral, Pheochromocytoma Benign | X X X | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 17 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 36 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 3 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X| 2 | Carcinoma | X X | 3 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X| 28 | Interstitial Cell, Adenoma | X | 7 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 20 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 10 | Leukemia Mononuclear | | 1 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | X | 1 | Lumbar, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X X X | 8 | Renal, Leukemia Mononuclear | X X | 4 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + M + + + M + + + M + + + + + + + + + +| 39 | Leukemia Mononuclear | X X X X X X X X X X X X | 25 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 44 | Leukemia Mononuclear | X X X X X X X X X X | 22 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + M + + M + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X X X X X X X X X | 27 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X X X X X | 25 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 29 | |__________________________________________________________________________|____________| Thymus | + M + + + + + M + + + + + M + + + + + + + + + + +| 43 | Leukemia Mononuclear | X X X X X X X | 16 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + M + M + M + + + + M + + M + + + + + M M +| 30 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma, Multiple | X | 1 | Fibroadenoma | X | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | X | 2 | Keratoacanthoma | X X X X | 5 | Sebaceous Gland, Carcinoma | X X | 2 | Subcutaneous Tissue, Fibroma | X | 4 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | Meningioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 28 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 6| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 3| 5| 6| 7| 5| 6| 7| 6| 5| 5| 5| 5| 6| | DAY ON TEST | 9| 8| 3| 3| 0| 9| 2| 3| 3| 8| 8| 3| 0| 9| 8| 3| 2| 5| 3| 8| 3| 9| 7| 9| 0| | | 0| 5| 5| 5| 2| 3| 7| 5| 5| 1| 5| 5| 2| 5| 6| 5| 2| 7| 5| 1| 6| 1| 2| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Zymbal's Gland | +| 1 | Carcinoma | X| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 23 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 29 | Mesothelioma Malignant | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | | Mesothelioma Malignant | X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | X X| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| |__________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| Pheochromocytoma Benign | X X X X X X X| Bilateral, Pheochromocytoma Benign | X X X X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Tunica Vaginalis, Mesothelioma | | Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | Mesothelioma Malignant | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + A + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node | + + + +| Leukemia Mononuclear | X X | Deep Cervical, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X| Renal, Leukemia Mononuclear | X X | |__________________________________________________________________________| Lymph Node, Bronchial | + M + + M M M + M + + + M + + + + M + + M + M M M| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + M + + + M + + + M + + + + M + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + M M M + + M M + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + M M M M + + + M M + M M M M + + + + M M + M M| Fibroadenoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Keratoacanthoma | | Leukemia Mononuclear | | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Turbinate, Osteosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Lateral Wall, Adenoma | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + | __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 7| 6| 6| 6| 4| 5| 7| 7| 5| 7| 4| 6| 4| 6| 4| 6| 6| 6| 7| 6| 4| 7| 7| 4| DAY ON TEST | 2| 1| 8| 0| 9| 6| 5| 2| 2| 7| 3| 7| 0| 9| 2| 9| 8| 0| 5| 0| 3| 9| 3| 3| 9| | 7| 6| 6| 6| 3| 2| 5| 6| 8| 1| 5| 7| 9| 0| 2| 0| 9| 4| 2| 5| 7| 0| 5| 5| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Lipoma | X | Renal Tubule, Adenoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X X| Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 31 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 13 | Leukemia Mononuclear | X X X | 3 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X | 7 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 14 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 24 | Pheochromocytoma Benign | X X X X X X | 13 | Bilateral, Pheochromocytoma Benign | X X X X X X | 14 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Parathyroid Gland | + + + + + + + + + M + + + + + + + M + M M + + + +| 45 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 21 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| 37 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + I + + + + + + +| 49 | C-Cell, Adenoma | X X X| 6 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | Tunica Vaginalis, Mesothelioma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 2 | |__________________________________________________________________________|____________| Penis | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Carcinoma | X X | 2 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | Leukemia Mononuclear | X X X | 6 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| 27 | Interstitial Cell, Adenoma | X X X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Leukemia Mononuclear | X | 3 | Deep Cervical, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Pancreatic, Leukemia Mononuclear | X X X | 5 | Renal, Leukemia Mononuclear | X | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + M M + + M M + M + + M M + M + + + M M| 28 | Leukemia Mononuclear | X X X X X X X X | 16 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + M M + + + + + + + + + + + + M +| 42 | Leukemia Mononuclear | X X X X X X X X X X X X | 23 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 26 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 31 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + M + + M + + + + M + + + + + + + + M + + +| 40 | Leukemia Mononuclear | X X X X X X X X X X X | 16 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + M M + + + + M M M + M + M M + + + + M + + + + M| 25 | Fibroadenoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Keratoacanthoma | X | 1 | Leukemia Mononuclear | X | 1 | Squamous Cell Papilloma | X | 2 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Schwannoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Turbinate, Osteosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 30 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | Lateral Wall, Adenoma | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 3 | |__________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X| 28 | Lipoma | | 1 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 3| 5| 7| 5| 5| 6| 6| 4| 5| 6| 6| 6| 5| 5| 6| 7| 6| 6| 6| 6| 6| 6| 6| 7| | DAY ON TEST | 9| 9| 4| 3| 7| 6| 0| 0| 7| 2| 2| 0| 8| 8| 7| 8| 2| 3| 9| 7| 1| 4| 1| 6| 3| | | 4| 9| 3| 5| 8| 0| 1| 9| 7| 5| 3| 9| 6| 1| 8| 9| 1| 7| 1| 8| 6| 4| 6| 0| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| 31 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Squamous Cell Papilloma | | __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X X X X| Bilateral, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X| Pheochromocytoma Malignant | X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X X X X X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| Leukemia Mononuclear | X X X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node | + + + + + + + +| Leukemia Mononuclear | X X | Deep Cervical, Leukemia Mononuclear | X X | Iliac, Leukemia Mononuclear | X X X X| Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | X X X | |__________________________________________________________________________| Lymph Node, Bronchial | M M + + + + + + M + + M M + M M + M + M + + M + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X X| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Kidney | | Leukemia Mononuclear | X X X X X X X X X X X X X X| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X X X X X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + + + + M + + + M M + + + + + + M + + + + + M +| Carcinoma | X X | Fibroadenoma | X X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X X | Basal Cell Carcinoma | X | Keratoacanthoma | X X X X X | Squamous Cell Carcinoma | X | Subcutaneous Tissue, Fibroma | X X X| Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Carcinoma, Metastatic, Kidney | | Carcinoma, Metastatic, Preputial | | Gland | X | Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| Pheochromocytoma Malignant, | | Metastatic, Adrenal Medulla | X | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 7| 7| 5| 5| 6| 7| 7| 7| 7| 6| 4| 7| 7| 6| 5| 6| 6| 7| 7| 5| 5| 6| 7| 6| 5| DAY ON TEST | 3| 3| 5| 0| 8| 0| 3| 0| 3| 9| 2| 3| 1| 4| 8| 3| 3| 0| 3| 9| 2| 6| 3| 7| 8| | 5| 5| 4| 5| 8| 8| 5| 0| 5| 2| 8| 5| 6| 6| 8| 9| 5| 8| 5| 2| 5| 6| 5| 1| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X| Respiratory Epithelium, Adenoma | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X X X X X X X| Nephroblastoma | | Stromal Nephroma | X | Renal Tubule, Adenoma | X X | Transitional Epithelium, Carcinoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Leukemia Mononuclear | X X X X X X X X X X X X X X X X| Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + A + A + + A + + + + + + + + + + + A + + A + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + A + + A + + + + + + + + + + + A + + A + +| 43 | Leukemia Mononuclear | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + A + A + + A + + + + + + + + + + + A + + A + +| 43 | Leukemia Mononuclear | X X X X | 4 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Leukemia Mononuclear | X X X X X X X X X X X X| 28 | |__________________________________________________________________________|____________| Mesentery | + + + +| 9 | Leukemia Mononuclear | X | 2 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X | 6 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 76 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 3 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 3 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X X X X X X | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 18 | Bilateral, Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X X X X X X X X | 15 | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X X X X X X X | 12 | Bilateral, Pheochromocytoma Benign | X X X X | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adenoma | | 2 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Leukemia Mononuclear | X X X X X X X X | 14 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| 39 | |__________________________________________________________________________|____________| Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Adenoma | X | 5 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 2 | Carcinoma | X | 5 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Seminal Vesicle | + + A + A + + + + + + + + + + + + + + A + + M + +| 46 | Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X| 27 | Interstitial Cell, Adenoma | X X X X X | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X | 21 | |__________________________________________________________________________|____________| Lymph Node | + + | 10 | Leukemia Mononuclear | X | 3 | Deep Cervical, Leukemia Mononuclear | | 2 | Iliac, Leukemia Mononuclear | X | 5 | Pancreatic, Leukemia Mononuclear | X X | 4 | Renal, Leukemia Mononuclear | X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + M + + + M + + + + + + + + M + M M M| 33 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 17 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Leukemia Mononuclear | X X X X X X X X X X X | 24 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Kidney | X | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 25 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + M + + + + M + + + M| 46 | Carcinoma, Metastatic, Kidney | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X | 25 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X| 28 | Mesothelioma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + M + + + + + + M M + M + + M + + + M + M + M| 41 | Leukemia Mononuclear | X X X X X X | 12 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M + + M M + M M + M M M M + + M M + M + + +| 29 | Carcinoma | | 2 | Fibroadenoma | X X| 5 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 3 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | X X | 7 | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Fibroma | X X | 5 | Subcutaneous Tissue, Fibroma, | | | Multiple | X | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Carcinoma, Metastatic, Kidney | X | 1 | Carcinoma, Metastatic, Preputial | | | Gland | | 1 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X| 26 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Medulla | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 12 | Respiratory Epithelium, Adenoma | X | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 6| 4| 5| 4| 5| 7| 5| 5| 6| 5| 5| 6| 5| 6| 6| 4| 5| 7| 6| 7| 6| 7| | DAY ON TEST | 9| 3| 7| 7| 7| 8| 7| 5| 0| 7| 4| 2| 7| 4| 6| 1| 9| 1| 8| 9| 3| 6| 3| 5| 3| | | 2| 6| 0| 9| 8| 5| 3| 9| 8| 1| 7| 1| 2| 6| 6| 9| 3| 6| 3| 7| 5| 5| 0| 2| 5| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X | 24 | Nephroblastoma | X | 1 | Stromal Nephroma | | 1 | Renal Tubule, Adenoma | | 2 | Transitional Epithelium, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Leukemia Mononuclear | X X X X X X X X X X X X| 28 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 4| 6| 6| 5| 6| 6| 6| 4| 6| 5| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| DAY ON TEST | 6| 9| 0| 6| 6| 1| 3| 8| 0| 1| 8| 7| 3| 2| 3| 5| 0| 2| 2| 7| 1| 9| 8| 8| 0| | 8| 4| 6| 8| 9| 3| 1| 1| 9| 0| 2| 6| 8| 6| 2| 5| 1| 2| 2| 2| 2| 3| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + A A + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 4| 6| 6| 5| 6| 6| 6| 4| 6| 5| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| DAY ON TEST | 6| 9| 0| 6| 6| 1| 3| 8| 0| 1| 8| 7| 3| 2| 3| 5| 0| 2| 2| 7| 1| 9| 8| 8| 0| | 8| 4| 6| 8| 9| 3| 1| 1| 9| 0| 2| 6| 8| 6| 2| 5| 1| 2| 2| 2| 2| 3| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X X | Bilateral, Pheochromocytoma Benign | X X X X X X X X X| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + A + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | Schwannoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 4| 6| 6| 5| 6| 6| 6| 4| 6| 5| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| DAY ON TEST | 6| 9| 0| 6| 6| 1| 3| 8| 0| 1| 8| 7| 3| 2| 3| 5| 0| 2| 2| 7| 1| 9| 8| 8| 0| | 8| 4| 6| 8| 9| 3| 1| 1| 9| 0| 2| 6| 8| 6| 2| 5| 1| 2| 2| 2| 2| 3| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Bilateral, Carcinoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node | + + + + + + + + | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | |__________________________________________________________________________| Lymph Node, Bronchial | M M M M + M + + M M M + + + M + M M M + + M M M +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + M + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + M + M + + + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | |__________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M + + + + + M| Leukemia Mononuclear | X X X X X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | |__________________________________________________________________________| Thymus | M + + M + + + + + + + + M M M M + + + M + + + + M| Leukemia Mononuclear | X X | __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 4| 6| 6| 5| 6| 6| 6| 4| 6| 5| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| DAY ON TEST | 6| 9| 0| 6| 6| 1| 3| 8| 0| 1| 8| 7| 3| 2| 3| 5| 0| 2| 2| 7| 1| 9| 8| 8| 0| | 8| 4| 6| 8| 9| 3| 1| 1| 9| 0| 2| 6| 8| 6| 2| 5| 1| 2| 2| 2| 2| 3| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + M + + M + + M + + M + + + M M + + + + + + + M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Respiratory Epithelium, Carcinoma | X | Respiratory Epithelium, Squamous | | Cell Carcinoma | X X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 _____________________________________________________________________________________________________________________ | 6| 5| 6| 5| 4| 6| 6| 5| 6| 6| 6| 4| 6| 5| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| DAY ON TEST | 6| 9| 0| 6| 6| 1| 3| 8| 0| 1| 8| 7| 3| 2| 3| 5| 0| 2| 2| 7| 1| 9| 8| 8| 0| | 8| 4| 6| 8| 9| 3| 1| 1| 9| 0| 2| 6| 8| 6| 2| 5| 1| 2| 2| 2| 2| 3| 1| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Harderian Gland | + | |__________________________________________________________________________| Zymbal's Gland | + + | Carcinoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________|__________________________________________________________________________| Page 87 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 6| 6| 5| 5| 6| 6| 6| 3| 6| 6| 6| 6| 5| 6| 4| 5| 6| 4| 6| 6| | DAY ON TEST | 0| 8| 5| 2| 8| 4| 1| 2| 8| 1| 7| 5| 4| 6| 5| 3| 3| 9| 3| 2| 8| 3| 9| 3| 2| | | 4| 0| 1| 1| 5| 9| 0| 2| 3| 5| 4| 0| 7| 4| 1| 8| 7| 9| 7| 1| 0| 7| 7| 8| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A A + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A A + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A A + + + + + A + + A + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A A + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 14 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + +| 26 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 88 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 6| 6| 5| 5| 6| 6| 6| 3| 6| 6| 6| 6| 5| 6| 4| 5| 6| 4| 6| 6| | DAY ON TEST | 0| 8| 5| 2| 8| 4| 1| 2| 8| 1| 7| 5| 4| 6| 5| 3| 3| 9| 3| 2| 8| 3| 9| 3| 2| | | 4| 0| 1| 1| 5| 9| 0| 2| 3| 5| 4| 0| 7| 4| 1| 8| 7| 9| 7| 1| 0| 7| 7| 8| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + +| 31 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 11 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X | 6 | Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X| 20 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | Pars Distalis, Adenoma | X X X X X X X X X X X| 31 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 6| 6| 5| 5| 6| 6| 6| 3| 6| 6| 6| 6| 5| 6| 4| 5| 6| 4| 6| 6| | DAY ON TEST | 0| 8| 5| 2| 8| 4| 1| 2| 8| 1| 7| 5| 4| 6| 5| 3| 3| 9| 3| 2| 8| 3| 9| 3| 2| | | 4| 0| 1| 1| 5| 9| 0| 2| 3| 5| 4| 0| 7| 4| 1| 8| 7| 9| 7| 1| 0| 7| 7| 8| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Penis | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 2 | Carcinoma | X X | 2 | Schwannoma Malignant | | 1 | Bilateral, Carcinoma | | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + A A + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X| 18 | Interstitial Cell, Adenoma | X X X X X X X X X X | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X | 11 | |__________________________________________________________________________|____________| Lymph Node | + + + + | 12 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | X X | 3 | |__________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M M + + + M + M + M M M M + M M M M + M +| 22 | Leukemia Mononuclear | X X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 | Leukemia Mononuclear | X X X X X X | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 6| 6| 5| 5| 6| 6| 6| 3| 6| 6| 6| 6| 5| 6| 4| 5| 6| 4| 6| 6| | DAY ON TEST | 0| 8| 5| 2| 8| 4| 1| 2| 8| 1| 7| 5| 4| 6| 5| 3| 3| 9| 3| 2| 8| 3| 9| 3| 2| | | 4| 0| 1| 1| 5| 9| 0| 2| 3| 5| 4| 0| 7| 4| 1| 8| 7| 9| 7| 1| 0| 7| 7| 8| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + M + + + + + + + + + + +| 45 | Leukemia Mononuclear | X X X X X X | 10 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + M M + + + M + + + + + + + + + + + + M + +| 44 | Leukemia Mononuclear | X X X X X | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + M + + + + + M M + + + +| 38 | Leukemia Mononuclear | X X | 4 | Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M + M M + + M M M M + + M + + M M M + M + M M +| 27 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X X X | 4 | Subcutaneous Tissue, Fibroma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 91 NTP Experiment-Test: 05201-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURFURYL ALCOHOL Date: 09/14/00 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:38:46 __________________________________________________________________________________________________________________________________ | 6| 5| 6| 5| 5| 6| 6| 5| 5| 6| 6| 6| 3| 6| 6| 6| 6| 5| 6| 4| 5| 6| 4| 6| 6| | DAY ON TEST | 0| 8| 5| 2| 8| 4| 1| 2| 8| 1| 7| 5| 4| 6| 5| 3| 3| 9| 3| 2| 8| 3| 9| 3| 2| | | 4| 0| 1| 1| 5| 9| 0| 2| 3| 5| 4| 0| 7| 4| 1| 8| 7| 9| 7| 1| 0| 7| 7| 8| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 14 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | Respiratory Epithelium, Carcinoma | | 1 | Respiratory Epithelium, Squamous | | | Cell Carcinoma | X | 3 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 3 | |__________________________________________________________________________|____________| Harderian Gland | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 3 | Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 12 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------