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TDMS Study 05201-05 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97

EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 18:43:54
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000
                

Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97     
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 18:43:54     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000  



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF            FURFURYL ALCOHOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
                                       Hypertrophy
                                       Vacuolization Cytoplasmic
Adrenal Medulla                        Hyperplasia
Blood Vessel: Aorta                    Mineralization
Bone                                   Fibrous Osteodystrophy
                                       Hyperostosis
Heart                                  Cardiomyopathy
Heart: Artery                          Mineralization
Heart: Atrium                          Thrombosis
Intestine Large, Cecum                 Parasite Metazoan
Intestine Large, Colon                 Mineralization
Intestine Large, Rectum                Mineralization
Islets, Pancreatic                     Hyperplasia
Kidney                                 Cyst
                                       Mineralization
                                       Nephropathy
Kidney: Renal Tubule                   Hyperplasia
Liver                                  Angiectasis
                                       Basophilic Focus
                                       Clear Cell Focus
                                       Degeneration Cystic
                                       Eosinophilic Focus
                                       Hepatodiaphragmatic Nodule
                                       Necrosis
Liver: Bile Duct                       Hyperplasia
Liver: Centrilobular                   Necrosis
Lung                                   Mineralization
Lung: Alveolar Epithelium              Hyperplasia
Lung: Artery, Mediastinum              Mineralization
Lymph Node, Mediastinal                Hemorrhage
Lymph Node: Renal                      Ectasia
                                       Hemorrhage
Mammary Gland                          Galactocele
Mesentery: Artery                      Inflammation Chronic
                                       Mineralization
Mesentery: Fat                         Necrosis
Nose                                   Inflammation
                                       Thrombosis
Nose: Glands                           Hyperplasia
Nose: Lateral Wall                     Hyperplasia
                                       Metaplasia
Nose: Olfactory Epithelium             Atrophy
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97     
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 18:43:54     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000  

                                       Degeneration Hyaline
                                       Fibrosis
                                       Hyperplasia
                                       Metaplasia
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
                                       Metaplasia
Pancreas                               Atrophy
                                       Hyperplasia
Pancreas: Artery                       Inflammation
                                       Mineralization
Parathyroid Gland                      Hyperplasia
Pituitary Gland: Pars Distalis         Hyperplasia
Preputial Gland                        Inflammation Chronic
Prostate                               Hyperplasia
Seminal Vesicle                        Mineralization
Skin: Tail                             Inflammation Chronic
Spleen                                 Fibrosis
                                       Hematopoietic Cell Proliferation
                                       Hemorrhage
Stomach, Forestomach                   Mineralization
Stomach, Glandular                     Mineralization
Testes                                 Atrophy
Testes: Artery                         Inflammation Chronic
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hyperplasia
                                       Vacuolization Cytoplasmic
Adrenal Medulla                        Hyperplasia
Heart                                  Cardiomyopathy
Kidney                                 Nephropathy
Kidney: Renal Tubule                   Hyperplasia
Liver                                  Basophilic Focus
                                       Degeneration Fatty
Nose                                   Inflammation
Nose: Glands                           Hyperplasia
Nose: Lateral Wall                     Hyperplasia
                                       Metaplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
                                       Fibrosis
                                       Hyperplasia
                                       Metaplasia
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Hyperplasia
                                       Metaplasia
Skin: Tail                             Inflammation Chronic
Stomach, Forestomach                   Necrosis
Stomach, Glandular                     Necrosis
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97     
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 18:43:54     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000  

Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  19/50 (38%)  20/50 (40%)  24/50 (48%) |19/50 (38%)  22/50 (44%)  21/48 (44%)  23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     42.1%        51.3%        53.9%        64.5%       |45.3%        49.5%        50.2%        57.6%        |
|TERMINAL (d)       |     4/8 (50%)    3/5 (60%)    8/9 (89%)    0/0 (0%)    |15/26 (58%)  14/26 (54%)  13/22 (59%)  11/16 (69%)  |
|FIRST INCIDENCE    |     581          477          519          421         |478          535          547          497          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.139      P=0.294      P<0.001 **  |P=0.013 *    P=0.376      P=0.244      P=0.019 *    |
|POLY 3             |     P=0.038 *    P=0.278      P=0.203      P=0.030 *   |P=0.172      P=0.431      P=0.406      P=0.176      |
|POLY 1.5           |     P=0.052      P=0.283      P=0.213      P=0.042 *   |P=0.232      P=0.400      P=0.399      P=0.219      |
|POLY 6             |     P=0.016 *    P=0.253      P=0.173      P=0.011 *   |P=0.115      P=0.485      P=0.404      P=0.133      |
|LOGISTIC REGRESSION|     P=0.009 **   P=0.224      P=0.206      P=0.014 *   |P=0.162      P=0.393      P=0.368      P=0.135      |
|COCH-ARM / FISHERS |     P=0.062      P=0.263      P=0.201      P=0.050     |P=0.322      P=0.342      P=0.354      P=0.272      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    4/50 (8%)   |2/50 (4%)    4/50 (8%)    6/48 (13%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     9.2%         9.3%         3.0%         13.8%       |4.9%         9.5%         14.9%        5.4%         |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |1/26 (4%)    3/26 (12%)   4/22 (18%)   2/16 (13%)   |
|FIRST INCIDENCE    |     681          601          616          583         |652          637          522          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.044 *    P=0.556      P=0.305N     P=0.070     |P=0.591N     P=0.353      P=0.109      P=0.547      |
|POLY 3             |     P=0.306      P=0.661      P=0.291N     P=0.435     |P=0.441N     P=0.355      P=0.128      P=0.664      |
|POLY 1.5           |     P=0.337      P=0.662N     P=0.295N     P=0.475     |P=0.407N     P=0.350      P=0.129      P=0.679      |
|POLY 6             |     P=0.246      P=0.643      P=0.289N     P=0.339     |P=0.490N     P=0.361      P=0.123      P=0.640      |
|LOGISTIC REGRESSION|     P=0.223      P=0.606      P=0.294N     P=0.328     |P=0.415N     P=0.355      P=0.122      P=0.638      |
|COCH-ARM / FISHERS |     P=0.362      P=0.661N     P=0.309N     P=0.500     |P=0.370N     P=0.339      P=0.121      P=0.691N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |4/50 (8%)    1/50 (2%)    0/48 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.9%         3.6%        |9.7%         2.4%         0.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          635          638         |604          679          ---          632          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.171      (e)          P=0.262      P=0.362     |P=0.357N     P=0.165N     P=0.075N     P=0.238N     |
|POLY 3             |     P=0.354      (e)          P=0.245      P=0.469     |P=0.311N     P=0.172N     P=0.066N     P=0.207N     |
|POLY 1.5           |     P=0.392      (e)          P=0.243      P=0.487     |P=0.303N     P=0.173N     P=0.064N     P=0.192N     |
|POLY 6             |     P=0.267      (e)          P=0.248      P=0.425     |P=0.321N     P=0.172N     P=0.072N     P=0.229N     |
|LOGISTIC REGRESSION|     P=0.343      (e)          P=0.243      P=0.462     |P=0.283N     P=0.182N     P=0.069N     P=0.178N     |
|COCH-ARM / FISHERS |     P=0.419      (e)          P=0.247      P=0.500     |P=0.290N     P=0.181N     P=0.064N     P=0.181N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    4/50 (8%)    8/50 (16%)  |5/50 (10%)   3/50 (6%)    3/48 (6%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     12.1%        9.3%         11.8%        26.5%       |12.3%        7.1%         7.6%         20.4%        |
|TERMINAL (d)       |     2/8 (25%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |3/26 (12%)   2/26 (8%)    2/22 (9%)    1/16 (6%)    |
|FIRST INCIDENCE    |     599          644          666          606         |573          651          623          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.634N     P=0.602N     P=0.002 **  |P=0.024 *    P=0.352N     P=0.432N     P=0.150      |
|POLY 3             |     P=0.035 *    P=0.510N     P=0.632N     P=0.121     |P=0.064      P=0.339N     P=0.375N     P=0.246      |
|POLY 1.5           |     P=0.047 *    P=0.500N     P=0.632N     P=0.153     |P=0.071      P=0.343N     P=0.371N     P=0.261      |
|POLY 6             |     P=0.019 *    P=0.535N     P=0.636N     P=0.067     |P=0.057      P=0.333N     P=0.388N     P=0.229      |
|LOGISTIC REGRESSION|     P=0.007 **   P=0.546N     P=0.633N     P=0.049 *   |P=0.069      P=0.337N     P=0.373N     P=0.260      |
|COCH-ARM / FISHERS |     P=0.059      P=0.500N     P=0.643N     P=0.178     |P=0.082      P=0.357N     P=0.381N     P=0.277      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  17/50 (34%)  24/50 (48%)  19/50 (38%) |12/50 (24%)  7/50 (14%)   10/48 (21%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     70.8%        45.8%        61.9%        52.4%       |28.8%        16.5%        24.5%        35.8%        |
|TERMINAL (d)       |     6/8 (75%)    1/5 (20%)    8/9 (89%)    0/0 (0%)    |7/26 (27%)   4/26 (15%)   3/22 (14%)   7/16 (44%)   |
|FIRST INCIDENCE    |     382          560          483          472         |581          581          547          497          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.035 *    P=0.088N     P=0.173N     P=0.210     |P=0.021 *    P=0.158N     P=0.520N     P=0.121      |
|POLY 3             |     P=0.197N     P=0.012N*    P=0.249N     P=0.052N    |P=0.093      P=0.137N     P=0.423N     P=0.329      |
|POLY 1.5           |     P=0.149N     P=0.008N**   P=0.183N     P=0.028N*   |P=0.115      P=0.140N     P=0.421N     P=0.371      |
|POLY 6             |     P=0.382N     P=0.027N*    P=0.412N     P=0.173N    |P=0.068      P=0.137N     P=0.435N     P=0.271      |
|LOGISTIC REGRESSION|     P=0.218N     P=0.007N**   P=0.123N     P=0.028N*   |P=0.097      P=0.132N     P=0.433N     P=0.323      |
|COCH-ARM / FISHERS |     P=0.135N     P=0.008N**   P=0.158N     P=0.022N*   |P=0.149      P=0.154N     P=0.447N     P=0.410      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/2 (100%)   2/2 (100%)   2/3 (67%)    31/31 (100%)|0/0 (0%)     1/1 (100%)   0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       74.7%        100.0%      |0.0%         100.0%       0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     686          637          692          555         |---          679          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.466N     (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.460      (e)          P=0.712N     (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.334      (e)          P=0.640N     (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.756      (e)          P=0.863N     (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.254      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.263      (e)          P=0.600N     (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   6/50 (12%)   34/50 (68%) |0/50 (0%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.1%         15.5%        17.6%        84.9%       |0.0%         2.4%         0.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     665          637          635          555         |---          679          ---          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.146      P=0.190      P<0.001 **  |P=0.398      P=0.518      (e)          P=0.403      |
|POLY 3             |     P<0.001 **   P=0.204      P=0.140      P<0.001 **  |P=0.459      P=0.509      (e)          P=0.484      |
|POLY 1.5           |     P<0.001 **   P=0.214      P=0.140      P<0.001 **  |P=0.468      P=0.506      (e)          P=0.492      |
|POLY 6             |     P<0.001 **   P=0.182      P=0.139      P<0.001 **  |P=0.445      P=0.512      (e)          P=0.473      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.151      P=0.136      P<0.001 **  |P=0.446      P=0.501      (e)          P=0.403      |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.218      P=0.134      P<0.001 **  |P=0.478      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Hyperostosis                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   1/50 (2%)    0/50 (0%)   |8/50 (16%)   14/50 (28%)  12/49 (24%)  6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     0.0%         15.0%        3.0%         0.0%        |19.4%        32.5%        28.2%        15.8%        |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |6/26 (23%)   8/26 (31%)   2/22 (9%)    2/16 (13%)   |
|FIRST INCIDENCE    |     ---          581          693          ---         |581          506          518          597          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.327N     P=0.027 *    P=0.513      (e)         |P=0.348N     P=0.132      P=0.186      P=0.576      |
|POLY 3             |     P=0.170N     P=0.030 *    P=0.507      (e)         |P=0.151N     P=0.129      P=0.244      P=0.446N     |
|POLY 1.5           |     P=0.149N     P=0.031 *    P=0.505      (e)         |P=0.125N     P=0.125      P=0.237      P=0.416N     |
|POLY 6             |     P=0.223N     P=0.028 *    P=0.507      (e)         |P=0.189N     P=0.136      P=0.251      P=0.485N     |
|LOGISTIC REGRESSION|     P=0.177N     P=0.032 *    P=0.506      (e)         |P=0.130N     P=0.130      P=0.216      P=0.445N     |
|COCH-ARM / FISHERS |     P=0.142N     P=0.028 *    P=0.500      (e)         |P=0.100N     P=0.114      P=0.212      P=0.387N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |2/49 (4%)    1/48 (2%)    1/48 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |5.1%         2.4%         2.6%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |2/26 (8%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |735 (T)      651          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.297N     P=0.487N     P=0.559N     P=0.350N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.233N     P=0.485N     P=0.502N     P=0.249N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.223N     P=0.492N     P=0.500N     P=0.240N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.475N     P=0.509N     P=0.261N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.242N     P=0.486N     P=0.559N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.209N     P=0.508N     P=0.508N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/49 (0%)    0/48 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          691          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.892N     P=0.175      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.418N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.404N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.442N     P=0.221      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.710N     P=0.193      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.394N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          616          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.591N     P=0.224      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.414N     P=0.235      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.400N     P=0.238      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.436N     P=0.227      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.433N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/44 (2%)    5/45 (11%)   2/46 (4%)    1/45 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.8%         13.1%        5.4%         3.0%         |
|TERMINAL (d)       |                                                        |1/24 (4%)    3/23 (13%)   2/21 (10%)   1/14 (7%)    |
|FIRST INCIDENCE    |                                                        |735 (T)      651          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.445N     P=0.104      P=0.453      P=0.638      |
|POLY 3             |                                                        |P=0.283N     P=0.118      P=0.520      P=0.748      |
|POLY 1.5           |                                                        |P=0.267N     P=0.115      P=0.523      P=0.757      |
|POLY 6             |                                                        |P=0.309N     P=0.122      P=0.510      P=0.733      |
|LOGISTIC REGRESSION|                                                        |P=0.360N     P=0.121      P=0.453      P=0.638      |
|COCH-ARM / FISHERS |                                                        |P=0.252N     P=0.107      P=0.517      P=0.747N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/44 (5%)    3/45 (7%)    1/46 (2%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |5.5%         7.9%         2.7%         0.0%         |
|TERMINAL (d)       |                                                        |0/24 (0%)    2/23 (9%)    1/21 (5%)    0/14 (0%)    |
|FIRST INCIDENCE    |                                                        |98           676          735 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.173N     P=0.511      P=0.539N     P=0.269N     |
|POLY 3             |                                                        |P=0.131N     P=0.521      P=0.491N     P=0.257N     |
|POLY 1.5           |                                                        |P=0.123N     P=0.516      P=0.486N     P=0.246N     |
|POLY 6             |                                                        |P=0.143N     P=0.527      P=0.504N     P=0.274N     |
|LOGISTIC REGRESSION|                                                        |P=0.100N     P=0.414      P=0.667N     P=0.278N     |
|COCH-ARM / FISHERS |                                                        |P=0.112N     P=0.511      P=0.483N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     2/3 (67%)    0/1 (0%)     1/3 (33%)   |0/1 (0%)     0/0 (0%)     0/1 (0%)     0/1 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         82.3%        0.0%         66.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/1 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          477          ---          638         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     38/50 (76%)  32/50 (64%)  40/50 (80%)  42/50 (84%) |29/50 (58%)  24/50 (48%)  23/49 (47%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     87.9%        77.8%        88.4%        94.0%       |67.4%        53.8%        54.4%        49.3%        |
|TERMINAL (d)       |     8/8 (100%)   5/5 (100%)   9/9 (100%)   0/0 (0%)    |20/26 (77%)  16/26 (62%)  15/22 (68%)  12/16 (75%)  |
|FIRST INCIDENCE    |     351          477          473          476         |581          506          589          497          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.525N     P=0.531      P<0.001 **  |P=0.479      P=0.209N     P=0.369N     P=0.513N     |
|POLY 3             |     P=0.035 *    P=0.120N     P=0.621      P=0.205     |P=0.137N     P=0.128N     P=0.141N     P=0.061N     |
|POLY 1.5           |     P=0.041 *    P=0.109N     P=0.542      P=0.217     |P=0.088N     P=0.149N     P=0.143N     P=0.042N*    |
|POLY 6             |     P=0.040 *    P=0.197N     P=0.711      P=0.213     |P=0.246N     P=0.109N     P=0.159N     P=0.114N     |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.102N     P=0.521      P=0.155     |P=0.136N     P=0.150N     P=0.156N     P=0.077N     |
|COCH-ARM / FISHERS |     P=0.060      P=0.138N     P=0.405      P=0.227     |P=0.052N     P=0.212N     P=0.184N     P=0.036N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    29/50 (58%) |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.2%         6.0%         76.5%       |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     686          637          692          555         |---          679          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.621      P=0.646N     P<0.001 **  |P=0.645N     P=0.518      (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.692      P=0.687N     P<0.001 **  |P=0.608N     P=0.509      (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.694N     P=0.687N     P<0.001 **  |P=0.607N     P=0.506      (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.678      P=0.691N     P<0.001 **  |P=0.607N     P=0.512      (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.656      P=0.686N     P<0.001 **  |P=0.613N     P=0.501      (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.691N     P=0.691N     P<0.001 **  |P=0.608N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   1/50 (2%)    3/50 (6%)   |3/50 (6%)    3/50 (6%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     9.1%         18.1%        3.0%         10.5%       |7.4%         7.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     684          490          616          521         |693          693          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.171      P=0.172      P=0.298N     P=0.037 *   |P=0.110N     P=0.640N     P=0.156N     P=0.177N     |
|POLY 3             |     P=0.494N     P=0.239      P=0.294N     P=0.599     |P=0.079N     P=0.646N     P=0.121N     P=0.134N     |
|POLY 1.5           |     P=0.454N     P=0.246      P=0.296N     P=0.639     |P=0.076N     P=0.650N     P=0.120N     P=0.126N     |
|POLY 6             |     P=0.576N     P=0.220      P=0.295N     P=0.495     |P=0.085N     P=0.641N     P=0.127N     P=0.147N     |
|LOGISTIC REGRESSION|     P=0.545N     P=0.214      P=0.295N     P=0.535     |P=0.083N     P=0.646N     P=0.123N     P=0.138N     |
|COCH-ARM / FISHERS |     P=0.424N     P=0.243      P=0.309N     P=0.661N    |P=0.072N     P=0.661N     P=0.125N     P=0.121N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/46 (4%)    2/49 (4%)    8/44 (18%)   4/45 (9%)   |5/49 (10%)   4/47 (9%)    8/46 (17%)   4/48 (8%)    |
|POLY-3 ADJUSTED (b)|     6.7%         6.3%         25.3%        14.9%       |12.7%        10.0%        20.7%        10.7%        |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     4/9 (44%)    0/0 (0%)    |4/26 (15%)   3/26 (12%)   6/22 (27%)   3/16 (19%)   |
|FIRST INCIDENCE    |     685          477          473          497         |707          721          546          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.039 *    P=0.633      P=0.056      P=0.082     |P=0.427      P=0.490N     P=0.185      P=0.528      |
|POLY 3             |     P=0.267      P=0.672N     P=0.047 *    P=0.284     |P=0.488N     P=0.486N     P=0.261      P=0.530N     |
|POLY 1.5           |     P=0.311      P=0.667N     P=0.044 *    P=0.312     |P=0.459N     P=0.499N     P=0.257      P=0.516N     |
|POLY 6             |     P=0.171      P=0.687N     P=0.051      P=0.216     |P=0.537N     P=0.469N     P=0.259      P=0.557N     |
|LOGISTIC REGRESSION|     P=0.307      P=0.677N     P=0.044 *    P=0.313     |P=0.502N     P=0.447N     P=0.244      P=0.529N     |
|COCH-ARM / FISHERS |     P=0.343      P=0.667N     P=0.038 *    P=0.328     |P=0.437N     P=0.527N     P=0.236      P=0.513N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/48 (2%)    9/47 (19%)  |0/50 (0%)    0/47 (0%)    0/48 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         3.1%         30.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/25 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          730          580         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.545      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   (e)          P=0.504      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   (e)          P=0.502      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   (e)          P=0.504      P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.521      P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.495      P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    6/48 (13%)   5/47 (11%)  |2/50 (4%)    3/47 (6%)    2/48 (4%)    3/48 (6%)    |
|POLY-3 ADJUSTED (b)|     9.2%         11.9%        17.2%        17.6%       |5.0%         7.6%         5.1%         8.1%         |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |2/26 (8%)    2/25 (8%)    2/22 (9%)    1/16 (6%)    |
|FIRST INCIDENCE    |     591          399          492          497         |735 (T)      693          735 (T)      599          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.087      P=0.432      P=0.268      P=0.086     |P=0.287      P=0.488      P=0.635      P=0.326      |
|POLY 3             |     P=0.270      P=0.516      P=0.271      P=0.276     |P=0.453      P=0.494      P=0.687      P=0.463      |
|POLY 1.5           |     P=0.316      P=0.520      P=0.257      P=0.312     |P=0.468      P=0.487      P=0.688      P=0.474      |
|POLY 6             |     P=0.182      P=0.504      P=0.290      P=0.198     |P=0.430      P=0.505      P=0.681      P=0.446      |
|LOGISTIC REGRESSION|     P=0.368      P=0.510      P=0.239      P=0.314     |P=0.400      P=0.510      P=0.635      P=0.439      |
|COCH-ARM / FISHERS |     P=0.351      P=0.511      P=0.233      P=0.334     |P=0.483      P=0.470      P=0.676      P=0.480      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/48 (0%)    2/47 (4%)   |0/50 (0%)    0/47 (0%)    0/47 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         7.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          522         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.015 *    (e)          (e)          P=0.135     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.032 *    (e)          (e)          P=0.208     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.036 *    (e)          (e)          P=0.226     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.026 *    (e)          (e)          P=0.169     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.046 *    (e)          (e)          P=0.244     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.040 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/47 (2%)    3/50 (6%)    4/48 (8%)    1/47 (2%)   |4/50 (8%)    3/47 (6%)    3/47 (6%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     3.3%         9.0%         12.0%        3.8%        |10.0%        7.5%         7.8%         8.2%         |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |4/26 (15%)   2/26 (8%)    3/22 (14%)   2/16 (13%)   |
|FIRST INCIDENCE    |     735 (T)      399          585          610         |735 (T)      547          735 (T)      733          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.556      P=0.231      P=0.212      P=0.477     |P=0.449      P=0.500N     P=0.594N     P=0.559      |
|POLY 3             |     P=0.468N     P=0.335      P=0.205      P=0.729     |P=0.563N     P=0.500N     P=0.520N     P=0.548N     |
|POLY 1.5           |     P=0.418N     P=0.336      P=0.198      P=0.749     |P=0.538N     P=0.511N     P=0.520N     P=0.529N     |
|POLY 6             |     P=0.583N     P=0.326      P=0.214      P=0.676     |P=0.599N     P=0.483N     P=0.527N     P=0.576N     |
|LOGISTIC REGRESSION|     P=0.407N     P=0.321      P=0.200      P=0.637     |P=0.594      P=0.505N     P=0.594N     (e)          |
|COCH-ARM / FISHERS |     P=0.382N     P=0.332      P=0.187      P=0.753N    |P=0.506N     P=0.535N     P=0.535N     P=0.511N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)   |0/49 (0%)    0/48 (0%)    2/48 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         3.7%        |0.0%         0.0%         5.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          693         |---          ---          522          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   (e)          (e)          P=0.035 *   |P=0.714N     (e)          P=0.228      (e)          |
|POLY 3             |     P=0.202      (e)          (e)          P=0.465     |P=0.676N     (e)          P=0.240      (e)          |
|POLY 1.5           |     P=0.215      (e)          (e)          P=0.484     |P=0.661N     (e)          P=0.239      (e)          |
|POLY 6             |     P=0.175      (e)          (e)          P=0.421     |P=0.697N     (e)          P=0.238      (e)          |
|LOGISTIC REGRESSION|     P=0.078      (e)          (e)          P=0.223     |P=0.625N     (e)          P=0.205      (e)          |
|COCH-ARM / FISHERS |     P=0.224      (e)          (e)          P=0.495     |P=0.644N     (e)          P=0.242      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     3.1%         9.4%         0.0%         13.9%       |0.0%         0.0%         0.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     690          694          ---          609         |---          ---          ---          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   P=0.226      P=0.488N     P=0.037 *   |P=0.215      (e)          (e)          P=0.495      |
|POLY 3             |     P=0.110      P=0.296      P=0.495N     P=0.138     |P=0.216      (e)          (e)          P=0.487      |
|POLY 1.5           |     P=0.126      P=0.304      P=0.496N     P=0.162     |P=0.223      (e)          (e)          P=0.493      |
|POLY 6             |     P=0.082      P=0.276      P=0.497N     P=0.094     |P=0.208      (e)          (e)          P=0.477      |
|LOGISTIC REGRESSION|     P=0.045 *    P=0.239      P=0.494N     P=0.120     |P=0.245      (e)          (e)          P=0.504      |
|COCH-ARM / FISHERS |     P=0.141      P=0.309      P=0.500N     P=0.181     |P=0.230      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.9%         0.0%        |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          666          ---         |---          428          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.721      (e)          P=0.258      (e)         |P=0.610N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.704N     (e)          P=0.245      (e)         |P=0.603N     P=0.509      (e)          (e)          |
|POLY 1.5           |     P=0.674N     (e)          P=0.243      (e)         |P=0.604N     P=0.505      (e)          (e)          |
|POLY 6             |     P=0.679      (e)          P=0.247      (e)         |P=0.602N     P=0.514      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.788N     (e)          P=0.243      (e)         |P=0.634N     P=0.329      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.652N     (e)          P=0.247      (e)         |P=0.606N     P=0.495      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     3.0%         6.1%         0.0%         3.6%        |4.9%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    1/26 (4%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     536          490          ---          521         |661          735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.697      P=0.480      P=0.490N     P=0.758N    |P=0.267N     P=0.487N     P=0.270N     P=0.287N     |
|POLY 3             |     P=0.628N     P=0.496      P=0.498N     P=0.724     |P=0.224N     P=0.494N     P=0.241N     P=0.257N     |
|POLY 1.5           |     P=0.610N     P=0.502      P=0.497N     P=0.746     |P=0.219N     P=0.497N     P=0.239N     P=0.247N     |
|POLY 6             |     P=0.657N     P=0.481      P=0.502N     P=0.666     |P=0.230N     P=0.490N     P=0.248N     P=0.272N     |
|LOGISTIC REGRESSION|     P=0.570N     P=0.480      P=0.551N     P=0.759     |P=0.227N     P=0.493N     P=0.240N     P=0.247N     |
|COCH-ARM / FISHERS |     P=0.594N     P=0.500      P=0.500N     P=0.753N    |P=0.211N     P=0.508N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    28/50 (56%) |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.2%         6.0%         74.7%       |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     686          637          692          555         |---          679          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.621      P=0.646N     P<0.001 **  |P=0.645N     P=0.518      (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.692      P=0.687N     P<0.001 **  |P=0.605N     P=0.506      (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.694N     P=0.687N     P<0.001 **  |P=0.605N     P=0.503      (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.678      P=0.691N     P<0.001 **  |P=0.604N     P=0.511      (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.656      P=0.686N     P<0.001 **  |P=0.612N     P=0.497      (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.691N     P=0.691N     P<0.001 **  |P=0.606N     P=0.495      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     50/50 (100%) 49/50 (98%)  50/50 (100%) 50/50 (100%)|47/50 (94%)  45/49 (92%)  47/49 (96%)  47/50 (94%)  |
|POLY-3 ADJUSTED (b)|     100.0%       99.4%        100.0%       100.0%      |98.8%        95.1%        98.3%        98.2%        |
|TERMINAL (d)       |     8/8 (100%)   5/5 (100%)   9/9 (100%)   0/0 (0%)    |26/26 (100%) 25/26 (96%)  22/22 (100%) 16/16 (100%) |
|FIRST INCIDENCE    |     302          399          428          347         |456          469          518          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.337      (e)          (e)         |P=0.008 **   P=0.375N     P=0.277      P=0.039 *    |
|POLY 3             |     P=0.994      P=0.990N     (e)          (e)         |P=0.561      P=0.289N     P=0.848N     P=0.831N     |
|POLY 1.5           |     P=0.855      P=0.795N     (e)          (e)         |P=0.575      P=0.314N     P=0.755N     P=0.683N     |
|POLY 6             |     P=1.000      P=1.000N     (e)          (e)         |P=0.543      P=0.301N     P=0.999N     P=0.999N     |
|LOGISTIC REGRESSION|     P=0.619      P=0.422N     (e)          (e)         |P=0.267      P=0.296N     P=0.395N     P=0.583      |
|COCH-ARM / FISHERS |     P=0.608      P=0.500N     (e)          (e)         |P=0.549      P=0.489N     P=0.510      P=0.661N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   2/50 (4%)    6/50 (12%)  |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     15.1%        15.3%        6.0%         20.6%       |0.0%         0.0%         0.0%         5.3%         |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     617          609          688          580         |---          ---          ---          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.486      P=0.188N     P<0.001 **  |P=0.022 *    (e)          (e)          P=0.178      |
|POLY 3             |     P=0.290      P=0.628      P=0.203N     P=0.407     |P=0.037 *    (e)          (e)          P=0.221      |
|POLY 1.5           |     P=0.334      P=0.630N     P=0.206N     P=0.464     |P=0.039 *    (e)          (e)          P=0.229      |
|POLY 6             |     P=0.209      P=0.607      P=0.204N     P=0.279     |P=0.034 *    (e)          (e)          P=0.210      |
|LOGISTIC REGRESSION|     P=0.082      P=0.568      P=0.199N     P=0.106     |P=0.035 *    (e)          (e)          P=0.217      |
|COCH-ARM / FISHERS |     P=0.371      P=0.630N     P=0.218N     P=0.500     |P=0.043 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    3/50 (6%)    4/50 (8%)   |3/50 (6%)    2/49 (4%)    3/49 (6%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     18.2%        6.3%         8.8%         14.1%       |7.5%         4.9%         7.5%         13.4%        |
|TERMINAL (d)       |     3/8 (38%)    2/5 (40%)    1/9 (11%)    0/0 (0%)    |3/26 (12%)   2/26 (8%)    1/22 (5%)    3/16 (19%)   |
|FIRST INCIDENCE    |     681          735 (T)      592          622         |735 (T)      735 (T)      679          707          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   P=0.262N     P=0.225N     P=0.008 **  |P=0.053      P=0.500N     P=0.593      P=0.144      |
|POLY 3             |     P=0.537      P=0.136N     P=0.216N     P=0.462N    |P=0.151      P=0.488N     P=0.662      P=0.314      |
|POLY 1.5           |     P=0.578      P=0.131N     P=0.224N     P=0.405N    |P=0.169      P=0.494N     P=0.662N     P=0.335      |
|POLY 6             |     P=0.452      P=0.154N     P=0.209N     P=0.605N    |P=0.129      P=0.479N     P=0.657      P=0.285      |
|LOGISTIC REGRESSION|     P=0.179      P=0.185N     P=0.223N     P=0.222     |P=0.088      P=0.500N     P=0.638      P=0.189      |
|COCH-ARM / FISHERS |     P=0.587N     P=0.134N     P=0.243N     P=0.370N    |P=0.192      P=0.510N     P=0.651      P=0.357      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   12/50 (24%)  27/50 (54%)  31/50 (62%) |30/50 (60%)  31/49 (63%)  34/49 (69%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     26.5%        35.0%        69.7%        77.0%       |69.1%        69.4%        76.5%        54.6%        |
|TERMINAL (d)       |     4/8 (50%)    4/5 (80%)    8/9 (89%)    0/0 (0%)    |22/26 (85%)  22/26 (85%)  21/22 (96%)  12/16 (75%)  |
|FIRST INCIDENCE    |     561          491          536          472         |478          497          522          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.130      P<0.001 **   P<0.001 **  |P=0.481      P=0.537      P=0.090      P=0.477      |
|POLY 3             |     P<0.001 **   P=0.300      P<0.001 **   P<0.001 **  |P=0.046N*    P=0.584      P=0.277      P=0.110N     |
|POLY 1.5           |     P<0.001 **   P=0.315      P<0.001 **   P<0.001 **  |P=0.029N*    P=0.542      P=0.273      P=0.089N     |
|POLY 6             |     P<0.001 **   P=0.262      P<0.001 **   P<0.001 **  |P=0.083N     P=0.569N     P=0.263      P=0.151N     |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.244      P<0.001 **   P<0.001 **  |P=0.053N     P=0.550      P=0.245      P=0.139N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.312      P<0.001 **   P<0.001 **  |P=0.018N*    P=0.449      P=0.222      P=0.080N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    4/50 (8%)    0/50 (0%)   |5/50 (10%)   6/49 (12%)   6/49 (12%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     15.1%        3.1%         12.0%        0.0%        |12.3%        14.4%        15.1%        8.1%         |
|TERMINAL (d)       |     2/8 (25%)    0/5 (0%)     3/9 (33%)    0/0 (0%)    |4/26 (15%)   5/26 (19%)   6/22 (27%)   3/16 (19%)   |
|FIRST INCIDENCE    |     609          686          730          ---         |631          581          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.530N     P=0.170N     P=0.445N     P=0.432N    |P=0.498N     P=0.505      P=0.389      P=0.604N     |
|POLY 3             |     P=0.094N     P=0.104N     P=0.497N     P=0.047N*   |P=0.277N     P=0.521      P=0.486      P=0.404N     |
|POLY 1.5           |     P=0.077N     P=0.101N     P=0.492N     P=0.036N*   |P=0.247N     P=0.511      P=0.495      P=0.380N     |
|POLY 6             |     P=0.145N     P=0.117N     P=0.517N     P=0.086N    |P=0.323N     P=0.535      P=0.463      P=0.441N     |
|LOGISTIC REGRESSION|     P=0.308N     P=0.122N     P=0.476N     P=0.150N    |P=0.346N     P=0.527      P=0.444      P=0.472N     |
|COCH-ARM / FISHERS |     P=0.067N     P=0.102N     P=0.500N     P=0.028N*   |P=0.214N     P=0.486      P=0.486      P=0.357N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.8%         0.0%        |2.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          492          ---         |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.644N     (e)          P=0.239      (e)         |P=0.629N     P=0.500N     P=0.533N     P=0.597N     |
|POLY 3             |     P=0.703N     (e)          P=0.250      (e)         |P=0.553N     P=0.495N     P=0.502N     P=0.516N     |
|POLY 1.5           |     P=0.674N     (e)          P=0.246      (e)         |P=0.551N     P=0.497N     P=0.501N     P=0.508N     |
|POLY 6             |     P=0.678      (e)          P=0.255      (e)         |P=0.554N     P=0.491N     P=0.507N     P=0.527N     |
|LOGISTIC REGRESSION|     P=0.642N     (e)          P=0.171      (e)         |P=0.629N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.652N     (e)          P=0.247      (e)         |P=0.545N     P=0.505N     P=0.505N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  18/50 (36%)  12/50 (24%)  9/50 (18%)  |0/50 (0%)    0/49 (0%)    1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     31.7%        49.4%        33.3%        29.4%       |0.0%         0.0%         2.5%         2.7%         |
|TERMINAL (d)       |     2/8 (25%)    2/5 (40%)    2/9 (22%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    1/16 (6%)    |
|FIRST INCIDENCE    |     561          560          554          581         |---          ---          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.081      P=0.064      P=0.551      P=0.012 *   |P=0.237      (e)          P=0.467      P=0.403      |
|POLY 3             |     P=0.205N     P=0.086      P=0.545      P=0.531N    |P=0.320      (e)          P=0.498      P=0.484      |
|POLY 1.5           |     P=0.147N     P=0.092      P=0.533      P=0.450N    |P=0.334      (e)          P=0.499      P=0.492      |
|POLY 6             |     P=0.382N     P=0.077      P=0.554      P=0.518     |P=0.299      (e)          P=0.493      P=0.473      |
|LOGISTIC REGRESSION|     P=0.341N     P=0.065      P=0.529      P=0.473     |(e)          (e)          P=0.467      P=0.403      |
|COCH-ARM / FISHERS |     P=0.117N     P=0.093      P=0.500      P=0.402N    |P=0.351      (e)          P=0.495      P=0.500      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   9/50 (18%)   3/50 (6%)    7/50 (14%)  |13/50 (26%)  9/49 (18%)   10/49 (20%)  17/50 (34%)  |
|POLY-3 ADJUSTED (b)|     14.2%        25.1%        8.8%         23.3%       |29.6%        21.1%        23.6%        40.8%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |3/26 (12%)   1/26 (4%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     382          490          571          580         |456          628          518          438          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.190      P=0.196      P=0.358N     P=0.146     |P=0.024 *    P=0.228N     P=0.402N     P=0.140      |
|POLY 3             |     P=0.357      P=0.190      P=0.373N     P=0.261     |P=0.048 *    P=0.256N     P=0.348N     P=0.192      |
|POLY 1.5           |     P=0.424      P=0.196      P=0.361N     P=0.324     |P=0.056      P=0.249N     P=0.334N     P=0.219      |
|POLY 6             |     P=0.241      P=0.179      P=0.393N     P=0.154     |P=0.041 *    P=0.260N     P=0.373N     P=0.170      |
|LOGISTIC REGRESSION|     P=0.529      P=0.161      P=0.399N     P=0.406     |P=0.088      P=0.270N     P=0.376N     P=0.269      |
|COCH-ARM / FISHERS |     P=0.486      P=0.194      P=0.357N     P=0.380     |P=0.073      P=0.251N     P=0.337N     P=0.257      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |3/50 (6%)    2/49 (4%)    4/49 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     12.2%        6.2%         8.8%         13.9%       |7.5%         4.9%         10.0%        2.7%         |
|TERMINAL (d)       |     2/8 (25%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |3/26 (12%)   2/26 (8%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     657          571          554          526         |735 (T)      735 (T)      679          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.022 *    P=0.469N     P=0.461N     P=0.009 **  |P=0.431N     P=0.500N     P=0.419      P=0.451N     |
|POLY 3             |     P=0.356      P=0.340N     P=0.476N     P=0.572     |P=0.301N     P=0.488N     P=0.499      P=0.328N     |
|POLY 1.5           |     P=0.398      P=0.334N     P=0.482N     P=0.617     |P=0.282N     P=0.494N     P=0.501      P=0.316N     |
|POLY 6             |     P=0.271      P=0.360N     P=0.472N     P=0.457     |P=0.328N     P=0.479N     P=0.491      P=0.344N     |
|LOGISTIC REGRESSION|     P=0.268      P=0.379N     P=0.486N     P=0.317     |P=0.321N     P=0.500N     P=0.464      P=0.335N     |
|COCH-ARM / FISHERS |     P=0.433      P=0.339N     P=0.500N     P=0.643N    |P=0.259N     P=0.510N     P=0.489      P=0.309N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    4/50 (8%)    6/50 (12%)  |4/50 (8%)    7/49 (14%)   6/49 (12%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         11.6%        20.1%       |9.7%         16.5%        14.6%        10.4%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |2/26 (8%)    5/26 (19%)   3/22 (14%)   1/16 (6%)    |
|FIRST INCIDENCE    |     ---          490          554          522         |98           506          518          438          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.504      P=0.077      P=0.004 **  |P=0.588N     P=0.269      P=0.326      P=0.499      |
|POLY 3             |     P=0.004 **   P=0.501      P=0.065      P=0.009 **  |P=0.433N     P=0.272      P=0.364      P=0.601      |
|POLY 1.5           |     P=0.006 **   P=0.502      P=0.064      P=0.013 *   |P=0.404N     P=0.262      P=0.364      P=0.618      |
|POLY 6             |     P=0.002 **   P=0.494      P=0.066      P=0.005 **  |P=0.477N     P=0.285      P=0.357      P=0.574      |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.420      P=0.065      P=0.016 *   |P=0.313N     P=0.201      P=0.279      P=0.630N     |
|COCH-ARM / FISHERS |     P=0.008 **   P=0.500      P=0.059      P=0.013 *   |P=0.362N     P=0.251      P=0.357      P=0.643N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |9/50 (18%)   13/49 (27%)  9/49 (18%)   8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         5.9%         7.1%        |21.7%        30.2%        21.6%        20.8%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |5/26 (19%)   8/26 (31%)   3/22 (14%)   4/16 (25%)   |
|FIRST INCIDENCE    |     ---          627          571          623         |599          497          546          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.105      P=0.484      P=0.250      P=0.154     |P=0.531      P=0.262      P=0.518      P=0.428      |
|POLY 3             |     P=0.213      P=0.498      P=0.245      P=0.205     |P=0.354N     P=0.260      P=0.599N     P=0.571N     |
|POLY 1.5           |     P=0.244      P=0.501      P=0.244      P=0.224     |P=0.310N     P=0.248      P=0.598N     P=0.534N     |
|POLY 6             |     P=0.153      P=0.491      P=0.247      P=0.165     |P=0.421N     P=0.276      P=0.601      P=0.594      |
|LOGISTIC REGRESSION|     P=0.227      P=0.500      P=0.242      P=0.209     |P=0.298N     P=0.237      P=0.591      P=0.553N     |
|COCH-ARM / FISHERS |     P=0.267      P=0.500      P=0.247      P=0.247     |P=0.262N     P=0.218      P=0.584      P=0.500N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/49 (2%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.2%         0.0%         7.2%        |2.4%         2.4%         0.0%         5.4%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     ---          637          ---          601         |470          506          ---          721          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058      P=0.219      (e)          P=0.046 *   |P=0.246      P=0.755N     P=0.496N     P=0.396      |
|POLY 3             |     P=0.249      P=0.235      (e)          P=0.204     |P=0.293      P=0.755N     P=0.506N     P=0.467      |
|POLY 1.5           |     P=0.272      P=0.238      (e)          P=0.223     |P=0.305      P=0.758N     P=0.503N     P=0.483      |
|POLY 6             |     P=0.205      P=0.227      (e)          P=0.163     |P=0.277      P=0.751N     P=0.512N     P=0.445      |
|LOGISTIC REGRESSION|     P=0.207      P=0.229      (e)          P=0.162     |P=0.352      P=0.654      P=0.650N     P=0.506      |
|COCH-ARM / FISHERS |     P=0.290      P=0.247      (e)          P=0.247     |P=0.321      P=0.747      P=0.505N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     3.0%         9.1%         6.0%         0.0%        |0.0%         2.4%         0.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     606          604          693          ---         |---          676          ---          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.310N     P=0.321      P=0.521      P=0.514N    |P=0.441      P=0.529      (e)          P=0.481      |
|POLY 3             |     P=0.224N     P=0.305      P=0.507      P=0.537N    |P=0.464      P=0.506      (e)          P=0.487      |
|POLY 1.5           |     P=0.194N     P=0.308      P=0.507      P=0.515N    |P=0.472      P=0.503      (e)          P=0.494      |
|POLY 6             |     P=0.299N     P=0.295      P=0.503      P=0.586N    |P=0.453      P=0.511      (e)          P=0.478      |
|LOGISTIC REGRESSION|     P=0.200N     P=0.304      P=0.509      P=0.500N    |P=0.498      P=0.496      (e)          P=0.499      |
|COCH-ARM / FISHERS |     P=0.173N     P=0.309      P=0.500      P=0.500N    |P=0.480      P=0.495      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  31/50 (62%)  30/50 (60%)  13/50 (26%) |6/50 (12%)   7/49 (14%)   6/49 (12%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     67.1%        75.6%        69.9%        38.7%       |14.8%        16.7%        14.5%        18.0%        |
|TERMINAL (d)       |     4/8 (50%)    3/5 (60%)    6/9 (67%)    0/0 (0%)    |3/26 (12%)   3/26 (12%)   0/22 (0%)    2/16 (13%)   |
|FIRST INCIDENCE    |     469          477          428          469         |693          651          547          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.445N     P=0.230      P=0.503      P=0.529N    |P=0.266      P=0.526      P=0.533      P=0.297      |
|POLY 3             |     P<0.001N**   P=0.250      P=0.481      P=0.006N**  |P=0.445      P=0.527      P=0.608N     P=0.470      |
|POLY 1.5           |     P<0.001N**   P=0.310      P=0.479      P=0.002N**  |P=0.471      P=0.513      P=0.612N     P=0.486      |
|POLY 6             |     P=0.009N**   P=0.163      P=0.457      P=0.051N    |P=0.410      P=0.546      P=0.609N     P=0.447      |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.346      P=0.447      P=0.003N**  |P=0.462      P=0.532      P=0.615      P=0.462      |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.342      P=0.420      P=0.002N**  |P=0.503      P=0.484      P=0.606      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  17/50 (34%)  15/50 (30%)  8/50 (16%)  |6/50 (12%)   6/49 (12%)   8/49 (16%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     32.3%        45.1%        37.9%        25.3%       |14.4%        14.0%        18.7%        22.3%        |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |1/26 (4%)    1/26 (4%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     382          490          428          469         |456          497          518          497          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.545N     P=0.168      P=0.370      P=0.411     |P=0.132      P=0.586N     P=0.349      P=0.194      |
|POLY 3             |     P=0.136N     P=0.175      P=0.389      P=0.350N    |P=0.189      P=0.604N     P=0.403      P=0.258      |
|POLY 1.5           |     P=0.084N     P=0.185      P=0.368      P=0.273N    |P=0.208      P=0.613N     P=0.397      P=0.273      |
|POLY 6             |     P=0.311N     P=0.163      P=0.415      P=0.553N    |P=0.166      P=0.589N     P=0.408      P=0.241      |
|LOGISTIC REGRESSION|     P=0.047N*    P=0.189      P=0.294      P=0.197N    |P=0.300      P=0.574      P=0.314      P=0.304      |
|COCH-ARM / FISHERS |     P=0.059N     P=0.189      P=0.326      P=0.227N    |P=0.236      P=0.606      P=0.371      P=0.288      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.9%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |456          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.339N     P=0.236N     P=0.263N     P=0.277N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.317N     P=0.233N     P=0.244N     P=0.259N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.314N     P=0.234N     P=0.241N     P=0.249N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.320N     P=0.232N     P=0.251N     P=0.275N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.297N     P=0.278N     P=0.286N     P=0.235N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.308N     P=0.247N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Granulomatous                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/49 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         0.0%         0.0%        |2.4%         0.0%         4.9%         8.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    2/16 (13%)   |
|FIRST INCIDENCE    |     ---          689          ---          ---         |470          ---          547          658          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.970N     P=0.487      (e)          (e)         |P=0.073      P=0.500N     P=0.505      P=0.217      |
|POLY 3             |     P=0.620N     P=0.497      (e)          (e)         |P=0.093      P=0.496N     P=0.498      P=0.273      |
|POLY 1.5           |     P=0.614N     P=0.501      (e)          (e)         |P=0.102      P=0.497N     P=0.500      P=0.288      |
|POLY 6             |     P=0.623N     P=0.489      (e)          (e)         |P=0.082      P=0.495N     P=0.493      P=0.254      |
|LOGISTIC REGRESSION|     P=0.759N     P=0.480      (e)          (e)         |P=0.135      P=0.627N     P=0.364      P=0.309      |
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.116      P=0.500N     P=0.492      P=0.309      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    24/50 (48%) |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     3.1%         6.2%         6.0%         66.8%       |0.0%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     727          637          692          555         |---          679          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.411      P=0.552      P<0.001 **  |P=0.645N     P=0.518      (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.497      P=0.512      P<0.001 **  |P=0.608N     P=0.509      (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.502      P=0.509      P<0.001 **  |P=0.607N     P=0.506      (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.484      P=0.513      P<0.001 **  |P=0.607N     P=0.512      (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.456      P=0.518      P<0.001 **  |P=0.613N     P=0.501      (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |P=0.608N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  7/50 (14%)   5/50 (10%)   8/50 (16%)  |9/50 (18%)   16/50 (32%)  13/49 (27%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     32.9%        21.2%        14.7%        25.6%       |22.2%        36.9%        30.5%        31.4%        |
|TERMINAL (d)       |     3/8 (38%)    2/5 (40%)    2/9 (22%)    0/0 (0%)    |7/26 (27%)   12/26 (46%)  5/22 (23%)   8/16 (50%)   |
|FIRST INCIDENCE    |     490          555          646          526         |661          469          547          525          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.121      P=0.300N     P=0.053N     P=0.490     |P=0.170      P=0.087      P=0.169      P=0.059      |
|POLY 3             |     P=0.498N     P=0.198N     P=0.060N     P=0.344N    |P=0.470      P=0.104      P=0.268      P=0.250      |
|POLY 1.5           |     P=0.450N     P=0.168N     P=0.053N     P=0.270N    |P=0.526      P=0.097      P=0.254      P=0.281      |
|POLY 6             |     P=0.543      P=0.273N     P=0.076N     P=0.535N    |P=0.393      P=0.115      P=0.282      P=0.206      |
|LOGISTIC REGRESSION|     P=0.529N     P=0.158N     P=0.049N*    P=0.235N    |P=0.466      P=0.098      P=0.226      P=0.181      |
|COCH-ARM / FISHERS |     P=0.416N     P=0.154N     P=0.054N     P=0.227N    |P=0.532N     P=0.083      P=0.218      P=0.312      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery, Mediastinum                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    26/50 (52%) |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     3.1%         6.2%         6.0%         70.3%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     727          637          692          555         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.411      P=0.552      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.497      P=0.512      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.502      P=0.509      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.484      P=0.513      P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.456      P=0.518      P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/47 (0%)    0/46 (0%)    2/44 (5%)   |0/43 (0%)    0/37 (0%)    1/45 (2%)    1/40 (3%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         8.1%        |0.0%         0.0%         2.7%         3.2%         |
|TERMINAL (d)       |     0/8 (0%)     0/3 (0%)     0/7 (0%)     0/0 (0%)    |0/24 (0%)    0/19 (0%)    0/20 (0%)    0/13 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          568         |---          ---          628          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   (e)          (e)          P=0.049 *   |P=0.330      (e)          P=0.500      P=0.495      |
|POLY 3             |     P=0.030 *    (e)          (e)          P=0.194     |P=0.328      (e)          P=0.512      P=0.480      |
|POLY 1.5           |     P=0.034 *    (e)          (e)          P=0.215     |P=0.337      (e)          P=0.513      P=0.485      |
|POLY 6             |     P=0.024 *    (e)          (e)          P=0.155     |P=0.313      (e)          P=0.508      P=0.471      |
|LOGISTIC REGRESSION|     P=0.031 *    (e)          (e)          P=0.198     |P=0.335      (e)          P=0.489      P=0.474      |
|COCH-ARM / FISHERS |     P=0.038 *    (e)          (e)          P=0.242     |P=0.342      (e)          P=0.511      P=0.482      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/10 (0%)    0/8 (0%)     0/10 (0%)    4/12 (33%)  |0/4 (0%)     0/5 (0%)     0/8 (0%)     1/11 (9%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         45.4%       |0.0%         0.0%         0.0%         10.7%        |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/2 (0%)     0/0 (0%)    |0/1 (0%)     0/1 (0%)     0/2 (0%)     0/5 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          594         |---          ---          ---          712          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.023 *   |P=0.176      (e)          (e)          P=0.440      |
|POLY 3             |     P=0.002 **   (e)          (e)          P=0.089     |P=0.359      (e)          (e)          P=0.694      |
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.077     |P=0.362      (e)          (e)          P=0.694      |
|POLY 6             |     P=0.002 **   (e)          (e)          P=0.108     |P=0.356      (e)          (e)          P=0.697      |
|LOGISTIC REGRESSION|     P=0.004 **   (e)          (e)          P=0.077     |P=0.370      (e)          (e)          P=0.702      |
|COCH-ARM / FISHERS |     P=0.004 **   (e)          (e)          P=0.068     |P=0.362      (e)          (e)          P=0.733      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node: Renal                                                                                                                |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/10 (10%)   0/8 (0%)     1/10 (10%)   3/12 (25%)  |0/4 (0%)     1/5 (20%)    1/8 (13%)    1/11 (9%)    |
|POLY-3 ADJUSTED (b)|     18.0%        0.0%         15.2%        36.1%       |0.0%         22.5%        16.2%        10.8%        |
|TERMINAL (d)       |     1/1 (100%)   0/1 (0%)     0/2 (0%)     0/0 (0%)    |0/1 (0%)     1/1 (100%)   0/2 (0%)     1/5 (20%)    |
|FIRST INCIDENCE    |     735 (T)      ---          688          601         |---          735 (T)      628          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   P=0.500N     P=0.671N     P=0.038 *   |P=0.579N     P=0.500      P=0.506      P=0.814      |
|POLY 3             |     P=0.130      P=0.499N     P=0.734N     P=0.451     |P=0.637N     P=0.547      P=0.615      P=0.693      |
|POLY 1.5           |     P=0.133      P=0.519N     P=0.748N     P=0.415     |P=0.637N     P=0.545      P=0.623      P=0.694      |
|POLY 6             |     P=0.114      P=0.466N     P=0.697N     P=0.515     |P=0.636N     P=0.553      P=0.611      P=0.694      |
|LOGISTIC REGRESSION|     P=0.088      (e)          P=0.634N     P=0.339     |P=0.640N     P=0.500      P=0.764      P=0.814      |
|COCH-ARM / FISHERS |     P=0.127      P=0.556N     P=0.763N     P=0.368     |P=0.645N     P=0.556      P=0.667      P=0.733      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/30 (20%)   2/25 (8%)    6/29 (21%)   7/27 (26%)  |3/50 (6%)    2/49 (4%)    1/49 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     26.6%        10.8%        27.3%        39.8%       |7.4%         4.8%         2.5%         13.2%        |
|TERMINAL (d)       |     2/7 (29%)    0/2 (0%)     3/8 (38%)    0/0 (0%)    |1/26 (4%)    2/26 (8%)    1/22 (5%)    1/16 (6%)    |
|FIRST INCIDENCE    |     591          644          621          610         |616          735 (T)      735 (T)      638          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.294N     P=0.583N     P=0.009 **  |P=0.057      P=0.490N     P=0.344N     P=0.238      |
|POLY 3             |     P=0.099      P=0.188N     P=0.614      P=0.286     |P=0.118      P=0.493N     P=0.313N     P=0.315      |
|POLY 1.5           |     P=0.133      P=0.185N     P=0.613      P=0.349     |P=0.128      P=0.496N     P=0.309N     P=0.336      |
|POLY 6             |     P=0.060      P=0.207N     P=0.610      P=0.186     |P=0.105      P=0.489N     P=0.326N     P=0.289      |
|LOGISTIC REGRESSION|     P=0.032 *    P=0.187N     P=0.626N     P=0.189     |P=0.102      P=0.488N     P=0.309N     P=0.319      |
|COCH-ARM / FISHERS |     P=0.183      P=0.193N     P=0.601      P=0.414     |P=0.144      P=0.510N     P=0.316N     P=0.357      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/11 (0%)    0/13 (0%)    0/9 (0%)     3/26 (12%)  |0/15 (0%)    0/8 (0%)     0/11 (0%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         17.4%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/2 (0%)     0/3 (0%)     0/0 (0%)    |0/10 (0%)    0/4 (0%)     0/7 (0%)     0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          637         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.035 *   |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.051      (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.059      (e)          (e)          P=0.278     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.038 *    (e)          (e)          P=0.208     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.081      (e)          (e)          P=0.291     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.068      (e)          (e)          P=0.335     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Artery                                                                                                                |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/11 (0%)    2/13 (15%)   0/9 (0%)     22/26 (85%) |0/15 (0%)    0/8 (0%)     0/11 (0%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         20.8%        0.0%         91.2%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/2 (0%)     0/3 (0%)     0/0 (0%)    |0/10 (0%)    0/4 (0%)     0/7 (0%)     0/2 (0%)     |
|FIRST INCIDENCE    |     ---          637          ---          555         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.207      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.252      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.259      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.247      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.239      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.283      (e)          P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/11 (0%)    2/13 (15%)   1/9 (11%)    2/26 (8%)   |1/15 (7%)    0/8 (0%)     0/11 (0%)    0/7 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         20.8%        12.8%        11.7%       |7.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     1/2 (50%)    0/3 (0%)     0/0 (0%)    |1/10 (10%)   0/4 (0%)     0/7 (0%)     0/2 (0%)     |
|FIRST INCIDENCE    |     ---          616          688          581         |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.121      P=0.319      P=0.523      P=0.226     |P=0.767N     P=0.682N     P=0.571N     P=0.814N     |
|POLY 3             |     P=0.611      P=0.253      P=0.484      P=0.397     |P=0.619N     P=0.641N     P=0.561N     P=0.682N     |
|POLY 1.5           |     P=0.646      P=0.260      P=0.472      P=0.419     |P=0.627N     P=0.634N     P=0.562N     P=0.669N     |
|POLY 6             |     P=0.539      P=0.247      P=0.508      P=0.355     |P=0.603N     P=0.651N     P=0.559N     P=0.698N     |
|LOGISTIC REGRESSION|     P=0.595N     P=0.244      P=0.475      P=0.671     |P=0.767N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.616N     P=0.283      P=0.450      P=0.488     |P=0.639N     P=0.652N     P=0.577N     P=0.682N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/11 (91%)  6/13 (46%)   7/9 (78%)    4/26 (15%)  |13/15 (87%)  7/8 (88%)    11/11 (100%) 6/7 (86%)    |
|POLY-3 ADJUSTED (b)|     92.5%        52.6%        79.4%        22.1%       |88.3%        90.0%        100.0%       96.8%        |
|TERMINAL (d)       |     1/1 (100%)   0/2 (0%)     2/3 (67%)    0/0 (0%)    |9/10 (90%)   4/4 (100%)   7/7 (100%)   2/2 (100%)   |
|FIRST INCIDENCE    |     578          578          616          580         |581          506          518          632          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.511      P=0.284N     P=0.167N     P=0.497     |P=0.371      P=0.535N     P=0.487      P=0.514      |
|POLY 3             |     P<0.001N**   P=0.030N*    P=0.424N     P<0.001N**  |P=0.465      P=0.725      P=0.345      P=0.587      |
|POLY 1.5           |     P<0.001N**   P=0.024N*    P=0.426N     P<0.001N**  |P=0.562      P=0.721      P=0.324      P=0.651      |
|POLY 6             |     P<0.001N**   P=0.045N*    P=0.422N     P<0.001N**  |P=0.424      P=0.728      P=0.387      P=0.559      |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.019N*    P=0.544N     P<0.001N**  |P=0.563      P=0.717      P=0.301      P=0.510      |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.027N*    P=0.421N     P<0.001N**  |P=0.679N     P=0.743N     P=0.323      P=0.705N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   17/50 (34%)  44/50 (88%) |4/49 (8%)    1/50 (2%)    5/48 (10%)   23/49 (47%)  |
|POLY-3 ADJUSTED (b)|     9.0%         18.4%        45.5%        95.6%       |9.9%         2.4%         12.6%        53.5%        |
|TERMINAL (d)       |     1/8 (13%)    2/5 (40%)    2/9 (22%)    0/0 (0%)    |2/26 (8%)    0/26 (0%)    2/22 (9%)    6/16 (38%)   |
|FIRST INCIDENCE    |     333          609          572          469         |456          707          679          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.158      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.183N     P=0.445      P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.221      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.167N     P=0.489      P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.234      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.168N     P=0.495      P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.195      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.165N     P=0.476      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.228      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.186N     P=0.490      P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.243      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.175N     P=0.487      P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  15/50 (30%)  11/50 (22%)  2/50 (4%)   |7/49 (14%)   3/50 (6%)    6/48 (13%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     26.8%        41.0%        28.7%        7.0%        |16.9%        7.1%         14.4%        13.0%        |
|TERMINAL (d)       |     0/8 (0%)     1/5 (20%)    0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     302          490          428          469         |456          651          518          597          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.040N*    P=0.162      P=0.505      P=0.063N    |P=0.503      P=0.150N     P=0.542N     P=0.482N     |
|POLY 3             |     P=0.008N**   P=0.139      P=0.532      P=0.037N*   |P=0.566      P=0.148N     P=0.497N     P=0.433N     |
|POLY 1.5           |     P=0.003N**   P=0.158      P=0.523      P=0.021N*   |P=0.581N     P=0.146N     P=0.497N     P=0.407N     |
|POLY 6             |     P=0.039N*    P=0.116      P=0.540      P=0.105N    |P=0.535      P=0.149N     P=0.503N     P=0.465N     |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.176      P=0.422      P=0.011N*   |P=0.495N     P=0.168N     P=0.605N     P=0.368N     |
|COCH-ARM / FISHERS |     P=0.002N**   P=0.178      P=0.500      P=0.014N*   |P=0.544N     P=0.151N     P=0.516N     P=0.380N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Glands                                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    22/50 (44%)  49/50 (98%) |0/49 (0%)    0/50 (0%)    24/48 (50%)  46/49 (94%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         54.1%        99.4%       |0.0%         0.0%         54.0%        97.0%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     3/9 (33%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    11/22 (50%)  15/16 (94%)  |
|FIRST INCIDENCE    |     ---          ---          473          347         |---          ---          518          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Lateral Wall                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    49/50 (98%)  50/50 (100%) 50/50 (100%)|0/49 (0%)    39/50 (78%)  48/48 (100%) 49/49 (100%) |
|POLY-3 ADJUSTED (b)|     3.1%         99.7%        100.0%       100.0%      |0.0%         79.5%        100.0%       100.0%       |
|TERMINAL (d)       |     0/8 (0%)     5/5 (100%)   9/9 (100%)   0/0 (0%)    |0/26 (0%)    17/26 (65%)  22/22 (100%) 16/16 (100%) |
|FIRST INCIDENCE    |     727          462          428          347         |---          428          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Lateral Wall                                                                                                               |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    8/50 (16%)   33/50 (66%) |0/49 (0%)    1/50 (2%)    0/48 (0%)    24/49 (49%)  |
|POLY-3 ADJUSTED (b)|     3.1%         3.1%         22.2%        79.2%       |0.0%         2.4%         0.0%         55.7%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    1/26 (4%)    0/22 (0%)    7/16 (44%)   |
|FIRST INCIDENCE    |     715          726          478          472         |---          735 (T)      ---          438          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.709      P=0.027 *    P<0.001 **  |P<0.001 **   P=0.500      (e)          P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.758      P=0.021 *    P<0.001 **  |P<0.001 **   P=0.512      (e)          P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.761      P=0.019 *    P<0.001 **  |P<0.001 **   P=0.510      (e)          P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.748      P=0.024 *    P<0.001 **  |P<0.001 **   P=0.515      (e)          P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.718      P=0.019 *    P<0.001 **  |P<0.001 **   P=0.500      (e)          P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.753N     P=0.015 *    P<0.001 **  |P<0.001 **   P=0.505      (e)          P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    12/50 (24%)  47/50 (94%)  50/50 (100%)|0/49 (0%)    6/50 (12%)   44/48 (92%)  49/49 (100%) |
|POLY-3 ADJUSTED (b)|     3.1%         33.2%        96.7%        100.0%      |0.0%         14.2%        91.7%        100.0%       |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    9/9 (100%)   0/0 (0%)    |0/26 (0%)    4/26 (15%)   18/22 (82%)  16/16 (100%) |
|FIRST INCIDENCE    |     735 (T)      490          428          347         |---          603          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.020 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.019 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.020 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.021 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  48/50 (96%)  50/50 (100%) 47/50 (94%) |43/49 (88%)  50/50 (100%) 47/48 (98%)  48/49 (98%)  |
|POLY-3 ADJUSTED (b)|     88.2%        97.0%        100.0%       95.9%       |91.6%        100.0%       97.9%        98.9%        |
|TERMINAL (d)       |     7/8 (88%)    5/5 (100%)   9/9 (100%)   0/0 (0%)    |24/26 (92%)  26/26 (100%) 21/22 (96%)  16/16 (100%) |
|FIRST INCIDENCE    |     302          399          428          347         |456          428          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.124      P=0.284      P<0.001 **  |P=0.007 **   P=0.231      P=0.137      P=0.010 *    |
|POLY 3             |     P=0.315      P=0.072      P=0.008 **   P=0.120     |P=0.231      P=0.040 *    P=0.160      P=0.089      |
|POLY 1.5           |     P=0.306      P=0.058      P=0.005 **   P=0.110     |P=0.237      P=0.031 *    P=0.125      P=0.087      |
|POLY 6             |     P=0.316      P=0.102      P=0.019 *    P=0.134     |P=0.225      P=0.061      P=0.226      P=0.097      |
|LOGISTIC REGRESSION|     P=0.370      P=0.049 *    P=0.004 **   P=0.168     |P=0.162      P=0.024 *    P=0.088      P=0.053      |
|COCH-ARM / FISHERS |     P=0.291      P=0.046 *    P=0.003 **   P=0.100     |P=0.185      P=0.012 *    P=0.059      P=0.056      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    26/50 (52%)  40/50 (80%) |0/49 (0%)    0/50 (0%)    16/48 (33%)  31/49 (63%)  |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         63.4%        87.4%       |0.0%         0.0%         39.2%        71.9%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     5/9 (56%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    9/22 (41%)   11/16 (69%)  |
|FIRST INCIDENCE    |     ---          490          473          347         |---          ---          547          497          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.504      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.501      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.502      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.494      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.420      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    42/50 (84%)  40/50 (80%) |0/49 (0%)    0/50 (0%)    31/48 (65%)  41/49 (84%)  |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         90.5%        86.9%       |0.0%         0.0%         71.7%        90.0%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     9/9 (100%)   0/0 (0%)    |0/26 (0%)    0/26 (0%)    17/22 (77%)  14/16 (88%)  |
|FIRST INCIDENCE    |     ---          490          428          347         |---          ---          518          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.504      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.501      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.502      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.494      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.420      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    8/50 (16%)   37/50 (74%)  49/50 (98%) |0/49 (0%)    5/50 (10%)   37/48 (77%)  48/49 (98%)  |
|POLY-3 ADJUSTED (b)|     3.1%         22.9%        84.0%        99.8%       |0.0%         11.9%        81.3%        99.6%        |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     9/9 (100%)   0/0 (0%)    |0/26 (0%)    4/26 (15%)   17/22 (77%)  16/16 (100%) |
|FIRST INCIDENCE    |     735 (T)      543          428          421         |---          603          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.034 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.036 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.035 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.038 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.018 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.039 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.030 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     12/50 (24%)  14/50 (28%)  45/50 (90%)  3/50 (6%)   |23/49 (47%)  39/50 (78%)  45/48 (94%)  6/49 (12%)   |
|POLY-3 ADJUSTED (b)|     31.7%        37.1%        92.9%        10.2%       |51.5%        82.1%        95.0%        15.4%        |
|TERMINAL (d)       |     1/8 (13%)    2/5 (40%)    9/9 (100%)   0/0 (0%)    |10/26 (39%)  20/26 (77%)  21/22 (96%)  1/16 (6%)    |
|FIRST INCIDENCE    |     302          462          428          347         |456          428          518          478          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.207N     P=0.333      P<0.001 **   P=0.116N    |P<0.001N**   P=0.017 *    P<0.001 **   P=0.007N**   |
|POLY 3             |     P=0.005N**   P=0.397      P<0.001 **   P=0.031N*   |P<0.001N**   P<0.001 **   P<0.001 **   P<0.001N**   |
|POLY 1.5           |     P<0.001N**   P=0.408      P<0.001 **   P=0.017N*   |P<0.001N**   P<0.001 **   P<0.001 **   P<0.001N**   |
|POLY 6             |     P=0.367N     P=0.371      P<0.001 **   P=0.099N    |P<0.001N**   P<0.001 **   P<0.001 **   P<0.001N**   |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.388      P<0.001 **   P=0.008N**  |P<0.001N**   P<0.001 **   P<0.001 **   P<0.001N**   |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.410      P<0.001 **   P=0.011N*   |P<0.001N**   P<0.001 **   P<0.001 **   P<0.001N**   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    26/50 (52%)  50/50 (100%) 50/50 (100%)|0/49 (0%)    18/50 (36%)  40/48 (83%)  49/49 (100%) |
|POLY-3 ADJUSTED (b)|     0.0%         63.6%        100.0%       100.0%      |0.0%         41.2%        83.9%        100.0%       |
|TERMINAL (d)       |     0/8 (0%)     2/5 (40%)    9/9 (100%)   0/0 (0%)    |0/26 (0%)    10/26 (39%)  16/22 (73%)  16/16 (100%) |
|FIRST INCIDENCE    |     ---          462          428          347         |---          547          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    26/50 (52%) |0/49 (0%)    0/50 (0%)    2/48 (4%)    10/49 (20%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         8.7%         67.6%       |0.0%         0.0%         5.0%         26.3%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    3/16 (19%)   |
|FIRST INCIDENCE    |     ---          ---          571          472         |---          ---          609          621          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.132      P<0.001 **  |P<0.001 **   (e)          P=0.236      P<0.001 **   |
|POLY 3             |     P<0.001 **   (e)          P=0.127      P<0.001 **  |P<0.001 **   (e)          P=0.241      P<0.001 **   |
|POLY 1.5           |     P<0.001 **   (e)          P=0.125      P<0.001 **  |P<0.001 **   (e)          P=0.240      P<0.001 **   |
|POLY 6             |     P<0.001 **   (e)          P=0.130      P<0.001 **  |P<0.001 **   (e)          P=0.240      P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.120      P<0.001 **  |P<0.001 **   (e)          P=0.207      P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.121      P<0.001 **  |P<0.001 **   (e)          P=0.242      P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    5/50 (10%)   6/49 (12%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|                                                        |7.5%         11.8%        14.5%        17.9%        |
|TERMINAL (d)       |                                                        |2/26 (8%)    4/26 (15%)   2/22 (9%)    2/16 (13%)   |
|FIRST INCIDENCE    |                                                        |707          428          518          581          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.069      P=0.360      P=0.203      P=0.082      |
|POLY 3             |                                                        |P=0.154      P=0.386      P=0.253      P=0.141      |
|POLY 1.5           |                                                        |P=0.168      P=0.378      P=0.250      P=0.150      |
|POLY 6             |                                                        |P=0.140      P=0.395      P=0.251      P=0.132      |
|LOGISTIC REGRESSION|                                                        |P=0.190      P=0.370      P=0.232      P=0.145      |
|COCH-ARM / FISHERS |                                                        |P=0.187      P=0.357      P=0.233      P=0.159      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/50 (44%)  22/50 (44%)  23/50 (46%)  17/49 (35%) |10/49 (20%)  11/49 (22%)  11/48 (23%)  11/50 (22%)  |
|POLY-3 ADJUSTED (b)|     56.8%        55.2%        57.5%        49.8%       |24.6%        25.8%        27.2%        27.5%        |
|TERMINAL (d)       |     6/8 (75%)    2/5 (40%)    5/9 (56%)    0/0 (0%)    |5/26 (19%)   7/26 (27%)   6/22 (27%)   3/16 (19%)   |
|FIRST INCIDENCE    |     469          477          478          497         |581          497          623          438          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.048 *    P=0.377      P=0.556      P=0.031 *   |P=0.194      P=0.522      P=0.388      P=0.266      |
|POLY 3             |     P=0.308N     P=0.535N     P=0.569      P=0.347N    |P=0.463      P=0.549      P=0.494      P=0.482      |
|POLY 1.5           |     P=0.214N     P=0.541N     P=0.552      P=0.266N    |P=0.497      P=0.536      P=0.499      P=0.505      |
|POLY 6             |     P=0.547N     P=0.545N     P=0.587      P=0.571N    |P=0.418      P=0.563      P=0.476      P=0.449      |
|LOGISTIC REGRESSION|     P=0.227N     P=0.578N     P=0.541      P=0.335N    |P=0.478      P=0.536      P=0.497      P=0.500      |
|COCH-ARM / FISHERS |     P=0.157N     P=0.580N     P=0.500      P=0.229N    |P=0.536      P=0.500      P=0.479      P=0.521      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    1/49 (2%)   |4/49 (8%)    1/49 (2%)    1/48 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     9.1%         3.1%         5.9%         3.6%        |10.1%        2.4%         2.6%         2.7%         |
|TERMINAL (d)       |     2/8 (25%)    1/5 (20%)    1/9 (11%)    0/0 (0%)    |2/26 (8%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    |
|FIRST INCIDENCE    |     606          735 (T)      505          583         |599          497          735 (T)      706          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.636      P=0.426N     P=0.465N     P=0.753     |P=0.384N     P=0.179N     P=0.229N     P=0.292N     |
|POLY 3             |     P=0.423N     P=0.314N     P=0.484N     P=0.368N    |P=0.308N     P=0.162N     P=0.182N     P=0.197N     |
|POLY 1.5           |     P=0.396N     P=0.306N     P=0.487N     P=0.334N    |P=0.293N     P=0.167N     P=0.180N     P=0.185N     |
|POLY 6             |     P=0.484N     P=0.336N     P=0.485N     P=0.459N    |P=0.328N     P=0.156N     P=0.189N     P=0.217N     |
|LOGISTIC REGRESSION|     P=0.488N     P=0.355N     P=0.488N     P=0.494N    |P=0.273N     P=0.190N     P=0.181N     P=0.196N     |
|COCH-ARM / FISHERS |     P=0.372N     P=0.309N     P=0.500N     P=0.316N    |P=0.271N     P=0.181N     P=0.187N     P=0.175N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    0/50 (0%)    2/49 (4%)   |1/49 (2%)    1/49 (2%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     14.8%        6.2%         0.0%         7.2%        |2.6%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    1/26 (4%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     572          616          ---          532         |735 (T)      735 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.583      P=0.278N     P=0.038N*    P=0.623     |P=0.440N     P=0.762      P=0.533N     P=0.597N     |
|POLY 3             |     P=0.394N     P=0.227N     P=0.029N*    P=0.295N    |P=0.355N     P=0.750N     P=0.500N     P=0.511N     |
|POLY 1.5           |     P=0.375N     P=0.218N     P=0.029N*    P=0.251N    |P=0.351N     P=0.753N     P=0.500N     P=0.503N     |
|POLY 6             |     P=0.429N     P=0.253N     P=0.031N*    P=0.418N    |P=0.360N     P=0.745N     P=0.504N     P=0.522N     |
|LOGISTIC REGRESSION|     P=0.406N     P=0.222N     P=0.031N*    P=0.286N    |P=0.440N     P=0.762      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.358N     P=0.218N     P=0.028N*    P=0.226N    |P=0.344N     P=0.753N     P=0.505N     P=0.495N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    5/49 (10%)  |0/49 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         0.0%         17.3%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          560          ---          606         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.500      (e)          P=0.009 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.500      (e)          P=0.019 *   |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.502      (e)          P=0.025 *   |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.493      (e)          P=0.011 *   |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.002 **   P=0.482      (e)          P=0.023 *   |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.002 **   P=0.500      (e)          P=0.027 *   |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Artery                                                                                                                 |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    3/49 (6%)   |0/49 (0%)    0/49 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         3.0%         10.8%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          730          638         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.545      P=0.003 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.015 *    (e)          P=0.506      P=0.090     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.019 *    (e)          P=0.505      P=0.105     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.010 *    (e)          P=0.505      P=0.064     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.002 **   (e)          P=0.521      P=0.036 *   |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.022 *    (e)          P=0.500      P=0.117     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   5/45 (11%)   12/50 (24%)  39/49 (80%) |1/46 (2%)    1/43 (2%)    1/44 (2%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     26.8%        17.2%        34.1%        92.2%       |2.7%         2.8%         2.8%         2.9%         |
|TERMINAL (d)       |     2/8 (25%)    1/5 (20%)    4/9 (44%)    0/0 (0%)    |0/24 (0%)    0/22 (0%)    0/19 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     522          716          546          532         |707          679          670          715          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.381N     P=0.390      P<0.001 **  |P=0.610      P=0.750N     P=0.733      P=0.686      |
|POLY 3             |     P<0.001 **   P=0.267N     P=0.341      P<0.001 **  |P=0.663      P=0.755      P=0.753      P=0.747      |
|POLY 1.5           |     P<0.001 **   P=0.248N     P=0.344      P<0.001 **  |P=0.675      P=0.753      P=0.755      P=0.754      |
|POLY 6             |     P<0.001 **   P=0.315N     P=0.333      P<0.001 **  |P=0.647      P=0.758      P=0.748      P=0.737      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.294N     P=0.325      P<0.001 **  |P=0.677      P=0.754      P=0.755      P=0.740      |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.244N     P=0.331      P<0.001 **  |P=0.672N     P=0.736      P=0.742      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/48 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    3/48 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         3.6%        |0.0%         0.0%         7.7%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    2/22 (9%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          599         |---          ---          693          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.221      (e)          (e)          P=0.494     |P=0.696N     (e)          P=0.098      (e)          |
|POLY 3             |     P=0.207      (e)          (e)          P=0.469     |P=0.623N     (e)          P=0.113      (e)          |
|POLY 1.5           |     P=0.220      (e)          (e)          P=0.488     |P=0.602N     (e)          P=0.114      (e)          |
|POLY 6             |     P=0.180      (e)          (e)          P=0.426     |P=0.652N     (e)          P=0.109      (e)          |
|LOGISTIC REGRESSION|     P=0.236      (e)          (e)          P=0.503     |P=0.644N     (e)          P=0.106      (e)          |
|COCH-ARM / FISHERS |     P=0.229      (e)          (e)          P=0.500     |P=0.577N     (e)          P=0.114      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    8/50 (16%)   3/48 (6%)    11/50 (22%) |8/50 (16%)   10/49 (20%)  7/48 (15%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     11.8%        23.2%        9.0%         34.1%       |18.9%        23.5%        17.3%        22.5%        |
|TERMINAL (d)       |     1/8 (13%)    1/5 (20%)    0/9 (0%)     0/0 (0%)    |3/26 (12%)   6/26 (23%)   4/22 (18%)   3/16 (19%)   |
|FIRST INCIDENCE    |     469          490          473          347         |470          547          518          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.002 **   P=0.147      P=0.490N     P=0.002 **  |P=0.261      P=0.424      P=0.569N     P=0.315      |
|POLY 3             |     P=0.022 *    P=0.173      P=0.508N     P=0.025 *   |P=0.473      P=0.403      P=0.537N     P=0.448      |
|POLY 1.5           |     P=0.031 *    P=0.179      P=0.510N     P=0.036 *   |P=0.503      P=0.397      P=0.527N     P=0.473      |
|POLY 6             |     P=0.010 *    P=0.159      P=0.510N     P=0.009 **  |P=0.435      P=0.412      P=0.560N     P=0.416      |
|LOGISTIC REGRESSION|     P=0.049 *    P=0.178      P=0.555N     P=0.051     |P=0.567      P=0.373      P=0.558N     P=0.517      |
|COCH-ARM / FISHERS |     P=0.040 *    P=0.178      P=0.523N     P=0.045 *   |P=0.543      P=0.379      P=0.535N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    2/49 (4%)    4/50 (8%)   |                                                    |
|POLY-3 ADJUSTED (b)|     3.2%         0.0%         6.1%         13.8%       |                                                    |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     717          ---          708          568         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.545N     P=0.541      P=0.019 *   |                                                    |
|POLY 3             |     P=0.028 *    P=0.500N     P=0.509      P=0.146     |                                                    |
|POLY 1.5           |     P=0.034 *    P=0.496N     P=0.508      P=0.169     |                                                    |
|POLY 6             |     P=0.018 *    P=0.511N     P=0.508      P=0.100     |                                                    |
|LOGISTIC REGRESSION|     P=0.012 *    P=0.539N     P=0.517      P=0.136     |                                                    |
|COCH-ARM / FISHERS |     P=0.040 *    P=0.495N     P=0.500      P=0.187     |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    5/50 (10%)   0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     20.9%        9.3%         14.8%        0.0%        |                                                    |
|TERMINAL (d)       |     3/8 (38%)    1/5 (20%)    3/9 (33%)    0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     599          678          639          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.279N     P=0.275N     P=0.325N     P=0.251N    |                                                    |
|POLY 3             |     P=0.029N*    P=0.164N     P=0.368N     P=0.014N*   |                                                    |
|POLY 1.5           |     P=0.022N*    P=0.156N     P=0.366N     P=0.009N**  |                                                    |
|POLY 6             |     P=0.057N     P=0.186N     P=0.381N     P=0.033N*   |                                                    |
|LOGISTIC REGRESSION|     P=0.104N     P=0.195N     P=0.353N     P=0.064N    |                                                    |
|COCH-ARM / FISHERS |     P=0.018N*    P=0.159N     P=0.380N     P=0.006N**  |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   8/50 (16%)   3/50 (6%)    5/50 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     25.8%        23.0%        8.9%         17.2%       |                                                    |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     525          477          679          580         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.337      P=0.578N     P=0.063N     P=0.271     |                                                    |
|POLY 3             |     P=0.286N     P=0.504N     P=0.059N     P=0.297N    |                                                    |
|POLY 1.5           |     P=0.235N     P=0.492N     P=0.057N     P=0.232N    |                                                    |
|POLY 6             |     P=0.404N     P=0.543N     P=0.068N     P=0.479N    |                                                    |
|LOGISTIC REGRESSION|     P=0.290N     P=0.502N     P=0.054N     P=0.350N    |                                                    |
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.061N     P=0.194N    |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/46 (2%)    3/47 (6%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         3.2%         11.2%       |                                                    |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     ---          ---          692          610         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.525      P=0.009 **  |                                                    |
|POLY 3             |     P=0.015 *    (e)          P=0.497      P=0.089     |                                                    |
|POLY 1.5           |     P=0.018 *    (e)          P=0.494      P=0.102     |                                                    |
|POLY 6             |     P=0.010 *    (e)          P=0.499      P=0.063     |                                                    |
|LOGISTIC REGRESSION|     P=0.007 **   (e)          P=0.498      P=0.060     |                                                    |
|COCH-ARM / FISHERS |     P=0.022 *    (e)          P=0.484      P=0.113     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Cyst Epithelial Inclusion                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.2%         0.0%         0.0%        |2.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          678          ---          ---         |735 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.843N     P=0.207      (e)          (e)         |P=0.629N     P=0.500N     P=0.533N     P=0.597N     |
|POLY 3             |     P=0.415N     P=0.233      (e)          (e)         |P=0.553N     P=0.492N     P=0.504N     P=0.516N     |
|POLY 1.5           |     P=0.400N     P=0.237      (e)          (e)         |P=0.552N     P=0.494N     P=0.503N     P=0.508N     |
|POLY 6             |     P=0.438N     P=0.223      (e)          (e)         |P=0.554N     P=0.490N     P=0.508N     P=0.527N     |
|LOGISTIC REGRESSION|     P=0.583N     P=0.207      (e)          (e)         |P=0.629N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |P=0.546N     P=0.500N     P=0.510N     P=0.500N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Acute                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          490          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.389N     P=0.242      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.411N     P=0.239      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.398N     P=0.241      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.431N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.385N     P=0.195      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.390N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     3.1%         6.1%         6.0%         7.0%        |0.0%         4.8%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    1/26 (4%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     696          477          692          497         |---          679          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.135      P=0.457      P=0.536      P=0.235     |P=0.460N     P=0.250      (e)          (e)          |
|POLY 3             |     P=0.451      P=0.500      P=0.510      P=0.453     |P=0.395N     P=0.247      (e)          (e)          |
|POLY 1.5           |     P=0.490      P=0.504      P=0.509      P=0.482     |P=0.392N     P=0.244      (e)          (e)          |
|POLY 6             |     P=0.364      P=0.487      P=0.509      P=0.383     |P=0.399N     P=0.251      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.488      P=0.500      P=0.513      P=0.505     |P=0.417N     P=0.246      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.518      P=0.500      P=0.500      P=0.500     |P=0.390N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Tail                                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    6/50 (12%)   18/50 (36%) |0/50 (0%)    0/50 (0%)    0/48 (0%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     3.1%         6.1%         17.9%        51.8%       |0.0%         0.0%         0.0%         13.2%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     4/9 (44%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    2/16 (13%)   |
|FIRST INCIDENCE    |     727          578          671          476         |---          ---          ---          560          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.471      P=0.069      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.013 *    |
|POLY 3             |     P<0.001 **   P=0.503      P=0.056      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.025 *    |
|POLY 1.5           |     P<0.001 **   P=0.505      P=0.058      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.028 *    |
|POLY 6             |     P<0.001 **   P=0.496      P=0.053      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.021 *    |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.499      P=0.054      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.026 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.056      P<0.001 **  |P<0.001 **   (e)          (e)          P=0.028 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Accessory Spleen                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/49 (0%)    2/49 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     8.9%         0.0%         0.0%         3.6%        |0.0%         0.0%         5.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    |
|FIRST INCIDENCE    |     536          ---          ---          693         |---          ---          623          632          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.677      P=0.131N     P=0.121N     P=0.689N    |P=0.359      (e)          P=0.224      P=0.500      |
|POLY 3             |     P=0.549N     P=0.126N     P=0.118N     P=0.379N    |P=0.386      (e)          P=0.242      P=0.491      |
|POLY 1.5           |     P=0.543N     P=0.121N     P=0.116N     P=0.335N    |P=0.404      (e)          P=0.242      P=0.498      |
|POLY 6             |     P=0.548N     P=0.141N     P=0.123N     P=0.486N    |P=0.361      (e)          P=0.238      P=0.482      |
|LOGISTIC REGRESSION|     P=0.552N     P=0.121N     P=0.124N     P=0.340N    |P=0.430      (e)          P=0.239      P=0.508      |
|COCH-ARM / FISHERS |     P=0.532N     P=0.121N     P=0.121N     P=0.309N    |P=0.425      (e)          P=0.247      P=0.505      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  13/50 (26%)  10/50 (20%)  12/50 (24%) |5/49 (10%)   3/49 (6%)    3/49 (6%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     39.7%        35.9%        27.8%        36.7%       |12.8%        7.2%         7.4%         13.3%        |
|TERMINAL (d)       |     3/8 (38%)    0/5 (0%)     2/9 (22%)    0/0 (0%)    |5/26 (19%)   0/26 (0%)    1/22 (5%)    2/16 (13%)   |
|FIRST INCIDENCE    |     522          462          492          472         |735 (T)      693          609          670          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.016 *    P=0.497      P=0.236N     P=0.004 **  |P=0.211      P=0.347N     P=0.429N     P=0.377      |
|POLY 3             |     P=0.552N     P=0.464N     P=0.197N     P=0.498N    |P=0.373      P=0.323N     P=0.338N     P=0.608      |
|POLY 1.5           |     P=0.483N     P=0.470N     P=0.210N     P=0.435N    |P=0.399      P=0.334N     P=0.340N     P=0.626      |
|POLY 6             |     P=0.430      P=0.467N     P=0.187N     P=0.565     |P=0.340      P=0.306N     P=0.340N     P=0.585      |
|LOGISTIC REGRESSION|     P=0.546      P=0.521N     P=0.212N     P=0.592     |P=0.340      P=0.308N     P=0.358N     P=0.529      |
|COCH-ARM / FISHERS |     P=0.436N     P=0.500N     P=0.241N     P=0.410N    |P=0.433      P=0.357N     P=0.357N     P=0.617N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |2/49 (4%)    4/49 (8%)    2/49 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     3.1%         6.1%         5.8%         13.8%       |5.0%         9.3%         5.0%         12.7%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |1/26 (4%)    0/26 (0%)    1/22 (5%)    0/16 (0%)    |
|FIRST INCIDENCE    |     679          399          546          522         |604          497          522          429          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.023 *    P=0.480      P=0.489      P=0.014 *   |P=0.144      P=0.362      P=0.669      P=0.162      |
|POLY 3             |     P=0.097      P=0.502      P=0.519      P=0.139     |P=0.197      P=0.376      P=0.688N     P=0.211      |
|POLY 1.5           |     P=0.117      P=0.505      P=0.513      P=0.162     |P=0.210      P=0.363      P=0.686N     P=0.219      |
|POLY 6             |     P=0.064      P=0.490      P=0.525      P=0.093     |P=0.181      P=0.393      P=0.694      P=0.198      |
|LOGISTIC REGRESSION|     P=0.152      P=0.490      P=0.488      P=0.149     |P=0.281      P=0.269      P=0.681      P=0.232      |
|COCH-ARM / FISHERS |     P=0.134      P=0.500      P=0.500      P=0.181     |P=0.223      P=0.339      P=0.691N     P=0.226      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |1/49 (2%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         10.3%       |2.5%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          421         |707          ---          589          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   (e)          (e)          P=0.089     |P=0.521N     P=0.494N     P=0.739      P=0.560N     |
|POLY 3             |     P=0.006 **   (e)          (e)          P=0.098     |P=0.499N     P=0.490N     P=0.756N     P=0.511N     |
|POLY 1.5           |     P=0.007 **   (e)          (e)          P=0.111     |P=0.489N     P=0.493N     P=0.755N     P=0.503N     |
|POLY 6             |     P=0.004 **   (e)          (e)          P=0.071     |P=0.514N     P=0.487N     P=0.760N     P=0.523N     |
|LOGISTIC REGRESSION|     P=0.009 **   (e)          (e)          P=0.098     |P=0.462N     P=0.489N     P=0.755      P=0.521N     |
|COCH-ARM / FISHERS |     P=0.008 **   (e)          (e)          P=0.121     |P=0.473N     P=0.500N     P=0.753N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/49 (2%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.0%         6.1%         8.7%         7.1%        |2.5%         2.4%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     532          490          580          610         |477          677          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.503      P=0.691N     P=0.497      P=0.654     |P=0.370N     P=0.745N     P=0.492N     P=0.500N     |
|POLY 3             |     P=0.563      P=0.690      P=0.512      P=0.633     |P=0.356N     P=0.753N     P=0.501N     P=0.514N     |
|POLY 1.5           |     P=0.612      P=0.695N     P=0.510      P=0.669     |P=0.352N     P=0.755N     P=0.498N     P=0.505N     |
|POLY 6             |     P=0.453      P=0.675      P=0.513      P=0.543     |P=0.361N     P=0.749N     P=0.507N     P=0.527N     |
|LOGISTIC REGRESSION|     P=0.578N     P=0.670      P=0.491      P=0.684N    |P=0.332N     P=0.716      P=0.641N     P=0.537N     |
|COCH-ARM / FISHERS |     P=0.600N     P=0.691N     P=0.500      P=0.691N    |P=0.344N     P=0.753N     P=0.500N     P=0.495N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    12/50 (24%) |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     3.1%         6.2%         6.0%         38.3%       |2.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     727          637          692          581         |616          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.411      P=0.552      P<0.001 **  |P=0.558N     P=0.485N     P=0.495N     P=0.505N     |
|POLY 3             |     P<0.001 **   P=0.497      P=0.512      P<0.001 **  |P=0.552N     P=0.494N     P=0.504N     P=0.518N     |
|POLY 1.5           |     P<0.001 **   P=0.502      P=0.509      P<0.001 **  |P=0.551N     P=0.495N     P=0.502N     P=0.509N     |
|POLY 6             |     P<0.001 **   P=0.484      P=0.513      P<0.001 **  |P=0.551N     P=0.493N     P=0.510N     P=0.530N     |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.456      P=0.518      P<0.001 **  |P=0.533N     P=0.526N     P=0.532N     P=0.496N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500      P=0.500      P<0.001 **  |P=0.546N     P=0.500N     P=0.505N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   6/50 (12%)   10/50 (20%)  6/50 (12%)  |5/50 (10%)   6/50 (12%)   5/49 (10%)   12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     25.5%        18.1%        27.7%        20.0%       |11.9%        13.9%        12.2%        30.3%        |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    1/16 (6%)    |
|FIRST INCIDENCE    |     490          571          571          421         |456          535          623          597          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.189      P=0.401N     P=0.540      P=0.334     |P=0.007 **   P=0.533      P=0.584      P=0.032 *    |
|POLY 3             |     P=0.455N     P=0.325N     P=0.522      P=0.409N    |P=0.011 *    P=0.519      P=0.612      P=0.034 *    |
|POLY 1.5           |     P=0.379N     P=0.298N     P=0.520      P=0.333N    |P=0.013 *    P=0.514      P=0.621      P=0.042 *    |
|POLY 6             |     P=0.525      P=0.389N     P=0.519      P=0.597N    |P=0.008 **   P=0.527      P=0.597      P=0.028 *    |
|LOGISTIC REGRESSION|     P=0.420N     P=0.294N     P=0.518      P=0.319N    |P=0.022 *    P=0.448      P=0.578      P=0.055      |
|COCH-ARM / FISHERS |     P=0.326N     P=0.288N     P=0.500      P=0.288N    |P=0.019 *    P=0.500      P=0.617      P=0.054      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    32/49 (65%) |2/50 (4%)    2/49 (4%)    1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.2%         8.9%         82.3%       |4.9%         4.8%         2.5%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    1/16 (6%)    |
|FIRST INCIDENCE    |     686          637          688          555         |599          679          735 (T)      735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.621      P=0.556      P<0.001 **  |P=0.522N     P=0.670N     P=0.519N     P=0.570N     |
|POLY 3             |     P<0.001 **   P=0.692      P=0.515      P<0.001 **  |P=0.443N     P=0.690N     P=0.511N     P=0.535N     |
|POLY 1.5           |     P<0.001 **   P=0.694N     P=0.512      P<0.001 **  |P=0.427N     P=0.692N     P=0.505N     P=0.517N     |
|POLY 6             |     P<0.001 **   P=0.678      P=0.517      P<0.001 **  |P=0.465N     P=0.688N     P=0.525N     P=0.560N     |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.656      P=0.515      P<0.001 **  |P=0.419N     P=0.675      P=0.522N     P=0.496N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.691N     P=0.500      P<0.001 **  |P=0.406N     P=0.684      P=0.508N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    4/50 (8%)    4/49 (8%)   |1/50 (2%)    2/49 (4%)    3/49 (6%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     20.0%        9.3%         11.6%        13.8%       |2.5%         4.8%         7.5%         18.4%        |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     382          678          554          472         |661          651          679          642          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.241      P=0.236N     P=0.253N     P=0.589     |P=0.003 **   P=0.527      P=0.285      P=0.018 *    |
|POLY 3             |     P=0.505N     P=0.185N     P=0.263N     P=0.372N    |P=0.007 **   P=0.510      P=0.302      P=0.023 *    |
|POLY 1.5           |     P=0.463N     P=0.168N     P=0.258N     P=0.312N    |P=0.008 **   P=0.505      P=0.304      P=0.026 *    |
|POLY 6             |     P=0.580      P=0.229N     P=0.280N     P=0.529N    |P=0.005 **   P=0.517      P=0.294      P=0.019 *    |
|LOGISTIC REGRESSION|     P=0.457N     P=0.159N     P=0.260N     P=0.261N    |P=0.006 **   P=0.496      P=0.301      P=0.024 *    |
|COCH-ARM / FISHERS |     P=0.430N     P=0.159N     P=0.262N     P=0.274N    |P=0.011 *    P=0.492      P=0.301      P=0.030 *    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 48
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    5/50 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     3.0%         3.1%         8.6%         17.3%       |                                                    |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     591          644          505          610         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.004 **   P=0.737      P=0.307      P=0.016 *   |                                                    |
|POLY 3             |     P=0.024 *    P=0.757      P=0.325      P=0.069     |                                                    |
|POLY 1.5           |     P=0.031 *    P=0.761      P=0.319      P=0.087     |                                                    |
|POLY 6             |     P=0.013 *    P=0.747      P=0.331      P=0.039 *   |                                                    |
|LOGISTIC REGRESSION|     P=0.039 *    P=0.762      P=0.265      P=0.065     |                                                    |
|COCH-ARM / FISHERS |     P=0.040 *    P=0.753N     P=0.309      P=0.102     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    4/50 (8%)    8/50 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     9.1%         3.1%         11.7%        26.1%       |                                                    |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     0/9 (0%)     0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     581          726          646          555         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.400N     P=0.534      P=0.010 *   |                                                    |
|POLY 3             |     P=0.007 **   P=0.318N     P=0.518      P=0.065     |                                                    |
|POLY 1.5           |     P=0.009 **   P=0.308N     P=0.514      P=0.084     |                                                    |
|POLY 6             |     P=0.003 **   P=0.343N     P=0.522      P=0.033 *   |                                                    |
|LOGISTIC REGRESSION|     P=0.004 **   P=0.327N     P=0.514      P=0.073     |                                                    |
|COCH-ARM / FISHERS |     P=0.012 *    P=0.309N     P=0.500      P=0.100     |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 49
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   4/50 (8%)    7/50 (14%)  |                                                    |
|POLY-3 ADJUSTED (b)|     11.4%        16.9%        11.1%        22.3%       |                                                    |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |                                                    |
|FIRST INCIDENCE    |     351          490          428          421         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.273      P=0.378      P=0.632N     P=0.273     |                                                    |
|POLY 3             |     P=0.183      P=0.371      P=0.633N     P=0.189     |                                                    |
|POLY 1.5           |     P=0.224      P=0.375      P=0.633N     P=0.230     |                                                    |
|POLY 6             |     P=0.115      P=0.358      P=0.637N     P=0.115     |                                                    |
|LOGISTIC REGRESSION|     P=0.292      P=0.244      P=0.426      P=0.239     |                                                    |
|COCH-ARM / FISHERS |     P=0.260      P=0.370      P=0.643N     P=0.262     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     27/49 (55%)  33/49 (67%)  30/49 (61%)  21/47 (45%) |40/49 (82%)  41/49 (84%)  35/47 (74%)  39/48 (81%)  |
|POLY-3 ADJUSTED (b)|     68.7%        76.2%        71.4%        58.9%       |86.7%        86.3%        78.7%        86.9%        |
|TERMINAL (d)       |     6/8 (75%)    2/5 (40%)    7/9 (78%)    0/0 (0%)    |22/26 (85%)  24/26 (92%)  17/22 (77%)  13/16 (81%)  |
|FIRST INCIDENCE    |     302          399          483          472         |456          428          518          302          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.117      P=0.128      P=0.446      P=0.044 *   |P=0.036 *    P=0.551      P=0.499N     P=0.090      |
|POLY 3             |     P=0.077N     P=0.285      P=0.492      P=0.235N    |P=0.503      P=0.603N     P=0.222N     P=0.617      |
|POLY 1.5           |     P=0.050N     P=0.228      P=0.432      P=0.203N    |P=0.549      P=0.615N     P=0.216N     P=0.595N     |
|POLY 6             |     P=0.196N     P=0.351      P=0.562      P=0.380N    |P=0.468      P=0.604N     P=0.244N     P=0.591      |
|LOGISTIC REGRESSION|     P=0.059N     P=0.155      P=0.389      P=0.265N    |P=0.521      P=0.572      P=0.215N     P=0.592      |
|COCH-ARM / FISHERS |     P=0.042N*    P=0.150      P=0.341      P=0.207N    |P=0.544N     P=0.500      P=0.274N     P=0.584N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 05                                            Page 50
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER344)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    2/49 (4%)    2/47 (4%)   |0/49 (0%)    0/49 (0%)    0/47 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     3.2%         3.2%         6.1%         7.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/8 (13%)    0/5 (0%)     1/9 (11%)    0/0 (0%)    |0/26 (0%)    0/26 (0%)    0/22 (0%)    0/16 (0%)    |
|FIRST INCIDENCE    |     735 (T)      525          708          585         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.083      P=0.709      P=0.556      P=0.163     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.334      P=0.760N     P=0.513      P=0.441     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.367      P=0.758N     P=0.510      P=0.469     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.263      P=0.761      P=0.516      P=0.375     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.298      P=0.762N     P=0.543      P=0.365     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.392      P=0.753N     P=0.500      P=0.484     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder: Transitional Epithelium                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/49 (0%)    2/49 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         3.1%         0.0%         0.0%        |0.0%         0.0%         5.0%         2.7%         |
|TERMINAL (d)       |     0/8 (0%)     0/5 (0%)     0/9 (0%)     0/0 (0%)    |0/26 (0%)    0/26 (0%)    1/22 (5%)    1/16 (6%)    |
|FIRST INCIDENCE    |     ---          689          ---          ---         |---          ---          518          735 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.970N     P=0.487      (e)          (e)         |P=0.327      (e)          P=0.230      P=0.403      |
|POLY 3             |     P=0.620N     P=0.497      (e)          (e)         |P=0.384      (e)          P=0.243      P=0.489      |
|POLY 1.5           |     P=0.614N     P=0.501      (e)          (e)         |P=0.403      (e)          P=0.243      P=0.497      |
|POLY 6             |     P=0.623N     P=0.489      (e)          (e)         |P=0.356      (e)          P=0.240      P=0.478      |
|LOGISTIC REGRESSION|     P=0.759N     P=0.480      (e)          (e)         |P=0.430      (e)          P=0.209      P=0.403      |
|COCH-ARM / FISHERS |     P=0.608N     P=0.500      (e)          (e)         |P=0.425      (e)          P=0.247      P=0.505      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).