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TDMS Study 05201-05 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 03/25/97       
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 20:34:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C       
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              CHRONIC                                                               
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 03/25/97      
EXPERIMENT: 05201 TEST: 05                                                                                     TIME: 20:34:11      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C      
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 0098-00-0000   
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      302   333   351   382   469   490   507   522   525   532                 |
 |      536   561   572   574   578   581   591   595   599   599                 |
 |      606   609   617   624   648   657   664   665   679   681                 |
 |      684   685   685   686   690   693   696   696   702   715                 |
 |      717   727                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 45     CENSORED DEATHS 0    TERMINAL 5         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      399   462   477   477   490   490   490   491   525   543                 |
 |      555   560   571   578   578   581   601   604   606   609                 |
 |      609   609   616   616   622   623   627   637   637   644                 |
 |      652   660   678   686   686   689   689   691   693   694                 |
 |      705   716   721   726   728                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 41     CENSORED DEATHS 0    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   473   478   483   492   505   519   525   536   546                 |
 |      547   554   559   571   572   580   585   588   592   597                 |
 |      616   621   635   639   646   652   665   666   666   670                 |
 |      671   679   688   692   693   700   708   708   708   716                 |
 |      730                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 32.0 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      347   421   469   472   476   497   521   522   526   532                 |
 |      555   568   580   580   581   581   583   585   594   599                 |
 |      601   604   606   609   609   610   610   612   613   615                 |
 |      622   622   623   631   637   637   637   638   638   638                 |
 |      649   650   651   651   664   668   674   681   682   693                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  94.0  92.0  90.0  78.0  60.0  44.0  16.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0 PPM    |   100.0 100.0 100.0 100.0  98.0  92.0  80.0  64.0  36.0  10.0      |
 |           |                                                                    |
 |           |                                                                    |
 |8.0 PPM    |   100.0 100.0 100.0 100.0 100.0  92.0  82.0  60.0  46.0  18.0      |
 |           |                                                                    |
 |           |                                                                    |
 |32.0 PPM   |   100.0 100.0 100.0  98.0  96.0  90.0  80.0  56.0  10.0   0.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      2.0 PPM      8.0 PPM      32.0 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       16.0%        10.0%        18.0%         0.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001      P=0.597      P=0.915N     P<0.001  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       595.8        607.6        607.3        593.3    |
 |NATURAL DEATHS (C)      |       (16.6)       (12.3)       (12.6)       ( 9.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       618.1        620.3        630.3        593.3    |
 |(STANDARD ERROR)        |       (15.7)       (12.3)       (12.4)       ( 9.9)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      98    456   470   477   478   573   581   581   599   604                 |
 |      609   609   616   627   631   652   661   673   693   707                 |
 |      707   707   707   721                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   469   497   506   535   547   571   581   603   628                 |
 |      637   651   651   676   677   679   690   693   707   708                 |
 |      716   721   727   732                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8.0 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      518   522   546   547   547   563   589   595   606   609                 |
 |      616   623   627   628   639   652   658   670   679   679                 |
 |      693   694   694   700   715   729   732                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 32.0 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      302   429   438   478   497   518   518   525   526   560                 |
 |      581   597   599   616   621   632   638   639   642   658                 |
 |      665   670   671   686   689   693   706   707   711   712                 |
 |      712   715   721   733                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                 FURFURYL ALCOHOL

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.0  98.0  98.0  98.0  90.0  90.0  80.0  66.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2.0 PPM    |   100.0 100.0 100.0 100.0 100.0  96.0  90.0  82.0  74.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |8.0 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  95.9  83.7  65.3  44.9      |
 |           |                                                                    |
 |           |                                                                    |
 |32.0 PPM   |   100.0 100.0 100.0  98.0  98.0  92.0  82.0  74.0  58.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      2.0 PPM      8.0 PPM      32.0 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.0%        52.0%        44.9%        32.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.028      P=0.982N     P=0.681      P=0.094  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       593.2        626.3        632.2        611.9    |
 |NATURAL DEATHS (C)      |       (27.0)       (18.3)       (12.3)       (17.5)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       666.9        682.8        678.4        651.3    |
 |(STANDARD ERROR)        |       (16.3)       (11.6)       (10.0)       (14.4)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          FURFURYL ALCOHOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.0 PPM          = 2
                                                        8.0 PPM          = 3
                                                        32.0 PPM         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                               1      4       2    3
      |                                                 1    1 4       2   43    2 3
      |                                                      1  1    1     4     2432
      |                                                              1            1 223
   90 +                                                                           14 13 3
      |                                                                              14 1  3
      |                                                                              22 1  143
      |                                                                                    1132
   80 +                                                                                     11232
      |                                                                                      1 3314
      |                                                                                         2112
      |                                                                                           11
P  70 +                                                                                           33
E     |                                                                                            13 12
R     |                                                                                             3 112
C     |                                                                                               33
E  60 +                                                                                                113
N     |                                                                                                4433
T     |                                                                                                 121133
      |                                                                                                  221 31
S  50 +                                                                                                 44    11
U     |                                                                                                   22   1 1
R     |                                                                                                    22    131
V     |                                                                                                     22     11
I  40 +                                                                                                  44  2 2
V     |                                                                                                        2 233
A     |                                                                                                   4 4    2 223
L     |                                                                                                             11
   30 +                                                                                                             223
      |                                                                                                              11 3
      |                                                                                                     44        11
      |                                                                                                              22131
   20 +                                                                                                      44       22 3  3
      |                                                                                                                2 11 3
      |                                                                                                                  21 1
      |                                                                                                       4  4
   10 +                                                                                                          44       2 2
      |                                                                                                           44
      |                                                                                                            44
      |                                                                                                             44
    0 +                                                                                                              4
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 55 obs hidden.
                                                          FURFURYL ALCOHOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2.0 PPM          = 2
                                                        8.0 PPM          = 3
                                                        32.0 PPM         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1              1                                4                   2            3
      |                1                                4                   2    12      3 3
      |                                                                     44   1211 2 2  3  33
      |                                                                             4 4 2    2
   90 +                                                                             1 4  4   2 2 31
      |                                                                                        2 311  3
P     |                                                                                  4 44     21   12
E     |                                                                                     4   4     311  2
R  80 +                                                                                         4  4    33 22
C     |                                                                                            4   4 33 2 2
E     |                                                                                                41131  2    2
N     |                                                                                                  44113
T  70 +                                                                                                   4 13 1
      |                                                                                                     44 1 1 2 2
S     |                                                                                                        3 131 1 2
U     |                                                                                                      4 4  33 1 12
R  60 +                                                                                                        4 4 3 3  22
V     |                                                                                                          44  33
I     |                                                                                                           4 4  1 12 2
V     |                                                                                                             44   1  1
A  50 +                                                                                                               3  3  3
L     |                                                                                                              4 4
      |                                                                                                                44   3
      |
   40 +
      |                                                                                                                 44
      |                                                                                                                  4  4
      |                                                                                                                     4
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 29 obs hidden.