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TDMS Study 05201-06 Pathology Tables

NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27

                                                         CHRONIC STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           12           15            8                                     
    Natural Death                                      5            3            2            2                                     
    Accidently Killed                                               1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           33           32           40                                     
  Other                                                             1                                                               
  Animals Examined Microscopically                    50           49           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (48)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
   Gallbladder                                        (43)         (45)         (47)         (41)                                   
      Degeneration, Hyaline                            1 (2%)                                                                       
      Inflammation, Suppurative                                     2 (4%)                                                          
   Intestine Large, Rectum                            (49)         (45)         (49)         (48)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Metaplasia, Squamous                                                       1 (2%)                                             
   Intestine Small, Duodenum                          (47)         (46)         (48)         (48)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Jejunum                           (45)         (46)         (48)         (48)                                   
      Peyer's Patch, Hyperplasia                                                 1 (2%)                                             
   Intestine Small, Ileum                             (45)         (47)         (48)         (48)                                   
      Peyer's Patch, Hyperplasia                                    1 (2%)       1 (2%)                                             
   Liver                                              (50)         (49)         (49)         (49)                                   
      Basophilic Focus                                                                        2 (4%)                                
      Clear Cell Focus                                                                        2 (4%)                                
      Degeneration, Fatty                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Eosinophilic Focus                              14 (28%)     19 (39%)     20 (41%)      8 (16%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                    5 (10%)      5 (10%)                               
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Chronic                                         4 (8%)       4 (8%)       1 (2%)                                
      Inflammation, Focal, Granulomatous               1 (2%)       2 (4%)                                                          
      Karyomegaly                                                                1 (2%)                                             
      Necrosis                                         2 (4%)       1 (2%)       4 (8%)       2 (4%)                                
      Pigmentation, Bile                                            1 (2%)                                                          
      Regeneration                                                               1 (2%)                                             
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Necrosis                                       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (15)         (6)          (11)         (10)                                   
      Angiectasis                                                                             1 (10%)                               
      Inflammation, Chronic                            1 (7%)                                 1 (10%)                               
      Fat, Hemorrhage                                                            1 (9%)       1 (10%)                               
      Fat, Necrosis                                   13 (87%)      6 (100%)     8 (73%)      7 (70%)                               
   Oral Mucosa                                                                               (1)                                    
      Pharyngeal, Hyperplasia                                                                 1 (100%)                              
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Atrophy                                          7 (14%)      3 (6%)       5 (10%)      9 (18%)                               
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Hypertrophy                                      1 (2%)                    2 (4%)       1 (2%)                                
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)                                                          
      Duct, Cyst                                                                              1 (2%)                                
   Stomach, Forestomach                               (50)         (48)         (49)         (49)                                   
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Suppurative                                     2 (4%)       1 (2%)                                             
      Ulcer                                                         3 (6%)                    1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)       8 (17%)      6 (12%)      3 (6%)                                
   Stomach, Glandular                                 (50)         (46)         (49)         (48)                                   
      Inflammation, Suppurative                                     2 (4%)       2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Inflammation                                                  1 (100%)                                                        
   Heart                                              (50)         (49)         (49)         (50)                                   
      Cardiomyopathy                                  36 (72%)     40 (82%)     46 (94%)     42 (84%)                               
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hyperplasia                                                   2 (4%)                                                          
      Hypertrophy                                      4 (8%)       1 (2%)       3 (6%)       3 (6%)                                
   Adrenal Medulla                                    (48)         (48)         (49)         (49)                                   
      Hyperplasia                                      4 (8%)       1 (2%)       2 (4%)       4 (8%)                                
   Islets, Pancreatic                                 (49)         (48)         (49)         (49)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       2 (4%)                                             
   Parathyroid Gland                                  (32)         (32)         (29)         (26)                                   
      Hyperplasia                                                                1 (3%)                                             
   Pituitary Gland                                    (48)         (48)         (48)         (49)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Angiectasis                                                                             1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Angiectasis                                    1 (2%)                    1 (2%)                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      15 (31%)     17 (35%)     15 (31%)     17 (35%)                               
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (49)         (49)                                   
      Inflammation                                     1 (2%)                                                                       
      Follicular Cell, Cyst                            1 (2%)                                                                       
      Follicular Cell, Hyperplasia                    17 (34%)     21 (43%)     17 (35%)     30 (61%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (48)         (49)                                   
      Angiectasis                                                   2 (4%)       1 (2%)                                             
      Atrophy                                          4 (8%)       3 (6%)       1 (2%)       2 (4%)                                
      Cyst                                            14 (28%)     14 (29%)     18 (38%)     15 (31%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Corpus Luteum, Hemorrhage                        1 (2%)                                                                       
      Corpus Luteum, Hyperplasia                                    1 (2%)                                                          
      Germinal Epithelium, Hyperplasia                 1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)       2 (4%)       1 (2%)                                             
   Uterus                                             (50)         (49)         (49)         (49)                                   
      Angiectasis                                      3 (6%)                    4 (8%)       2 (4%)                                
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hydrometra                                       5 (10%)      5 (10%)      4 (8%)       3 (6%)                                
      Hyperplasia, Cystic                              4 (8%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    1 (2%)                                
      Thrombosis                                       1 (2%)       2 (4%)       1 (2%)                                             
      Endometrium, Hyperplasia                                                   1 (2%)       1 (2%)                                
      Endometrium, Metaplasia                                                                 1 (2%)                                
      Myometrium, Hyperplasia                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (49)                                   
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Lymph Node                                         (6)          (4)          (5)          (4)                                    
      Angiectasis                                      4 (67%)      3 (75%)      2 (40%)                                            
      Necrosis                                         1 (17%)                                                                      
      Renal, Hyperplasia                                            1 (25%)      1 (20%)                                            
   Lymph Node, Bronchial                              (33)         (27)         (30)         (37)                                   
      Hyperplasia                                      1 (3%)       1 (4%)       1 (3%)       2 (5%)                                
   Lymph Node, Mandibular                             (36)         (40)         (43)         (40)                                   
      Hyperplasia                                      1 (3%)       2 (5%)                    2 (5%)                                
      Infiltration Cellular, Mast Cell                                           1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (47)         (47)         (46)                                   
      Angiectasis                                                   1 (2%)                    2 (4%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                                   2 (4%)       1 (2%)       1 (2%)                                
   Lymph Node, Mediastinal                            (41)         (34)         (40)         (40)                                   
      Hyperplasia                                      4 (10%)      1 (3%)       3 (8%)       2 (5%)                                
   Spleen                                             (50)         (48)         (49)         (49)                                   
      Hematopoietic Cell Proliferation                11 (22%)     11 (23%)     12 (24%)     17 (35%)                               
      Hyperplasia, Lymphoid                            8 (16%)      8 (17%)      4 (8%)       5 (10%)                               
   Thymus                                             (42)         (40)         (46)         (38)                                   
      Angiectasis                                                   1 (3%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (50)                                   
      Hyperplasia                                                   2 (4%)       1 (2%)       2 (4%)                                
   Skin                                               (50)         (49)         (49)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Angiectasis                 1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Granulomatous                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)                                   
      Fibrous Osteodystrophy                          16 (32%)     19 (39%)     15 (30%)     22 (44%)                               
      Fracture                                                      1 (2%)                                                          
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (49)                                   
      Gliosis                                                                                 1 (2%)                                
      Necrosis                                                      2 (4%)       1 (2%)                                             
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         4 (8%)       4 (8%)       2 (4%)       4 (8%)                                
   Peripheral Nerve                                                             (1)                                                 
      Degeneration                                                               1 (100%)                                           
   Spinal Cord                                        (2)                       (2)          (1)                                    
      Degeneration                                                               1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (49)         (50)         (49)                                   
      Hyperplasia                                      5 (10%)      9 (18%)      3 (6%)       5 (10%)                               
      Inflammation, Suppurative                                     3 (6%)                    1 (2%)                                
      Epiglottis, Metaplasia, Squamous                 1 (2%)                                                                       
   Lung                                               (50)         (49)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                3 (6%)       5 (10%)      2 (4%)       3 (6%)                                
      Inflammation, Chronic, Focal                     1 (2%)                                 1 (2%)                                
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    1 (2%)       2 (4%)                                
      Mediastinum, Inflammation, Chronic                            1 (2%)       1 (2%)                                             
   Nose                                               (50)         (48)         (49)         (50)                                   
      Inflammation, Suppurative                        5 (10%)     12 (25%)     25 (51%)     42 (84%)                               
      Glands, Hyperplasia                                          33 (69%)     46 (94%)     47 (94%)                               
      Glands, Metaplasia, Squamous                     1 (2%)       1 (2%)      34 (69%)     46 (92%)                               
      Lateral Wall, Metaplasia, Squamous               3 (6%)      14 (29%)     16 (33%)     36 (72%)                               
      Lateral Wall, Necrosis                                                     4 (8%)       1 (2%)                                
      Olfactory Epithelium, Atrophy                    2 (4%)      35 (73%)     49 (100%)    50 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline      7 (14%)     14 (29%)     28 (57%)     45 (90%)                               
      Olfactory Epithelium, Metaplasia                             31 (65%)     49 (100%)    49 (98%)                               
      Respiratory Epithelium, Degeneration, Hyaline   19 (38%)     44 (92%)     49 (100%)    48 (96%)                               
      Respiratory Epithelium, Hyperplasia, Polypoid                                           1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       9 (19%)     21 (43%)     39 (78%)                               
      Respiratory Epithelium, Necrosis                                           2 (4%)       3 (6%)                                
      Respiratory Epithelium, Regeneration                                       9 (18%)     13 (26%)                               
   Trachea                                            (50)         (48)         (49)         (48)                                   
      Metaplasia, Squamous                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (49)         (49)         (50)                                   
      Cataract                                         2 (4%)       1 (2%)                    1 (2%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               2 (4%)                                             
      Cornea, Degeneration                             3 (6%)       1 (2%)       4 (8%)      26 (52%)                               
      Cornea, Fibrosis                                 1 (2%)                                                                       
      Cornea, Hyperplasia                              2 (4%)                    4 (8%)       7 (14%)                               
      Cornea, Inflammation, Chronic Active             1 (2%)                    1 (2%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (49)         (49)                                   
      Metaplasia, Osseous                              1 (2%)       3 (6%)       2 (4%)       4 (8%)                                
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     41 (82%)     35 (73%)     40 (82%)     39 (80%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           10           14            8                                     
    Natural Death                                      5            4            6            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           36           30           38                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (42)         (42)         (43)                                   
      Degeneration, Hyaline                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (48)         (47)         (46)         (46)                                   
      Anus, Inflammation, Chronic Active               1 (2%)                                                                       
   Intestine Large, Cecum                             (48)         (47)         (46)         (48)                                   
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (48)         (46)         (47)                                   
      Peyer's Patch, Hyperplasia                                    1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (48)         (46)         (47)                                   
      Peyer's Patch, Hyperplasia                                                              1 (2%)                                
   Liver                                              (50)         (50)         (49)         (50)                                   
      Angiectasis                                                                             2 (4%)                                
      Basophilic Focus                                              5 (10%)                                                         
      Clear Cell Focus                                              3 (6%)       3 (6%)       1 (2%)                                
      Degeneration, Cystic                                          1 (2%)                                                          
      Degeneration, Fatty                              5 (10%)      1 (2%)                    1 (2%)                                
      Eosinophilic Focus                              13 (26%)     18 (36%)     12 (24%)     14 (28%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)       2 (4%)                                
      Necrosis                                         2 (4%)       4 (8%)       6 (12%)      2 (4%)                                
      Vacuolization Cytoplasmic                                     1 (2%)                    3 (6%)                                
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                                                                  1 (2%)                                
      Centrilobular, Degeneration                                                1 (2%)                                             
      Centrilobular, Necrosis                                                    1 (2%)                                             
   Mesentery                                          (7)          (4)          (7)          (3)                                    
      Fat, Necrosis                                    7 (100%)     4 (100%)     6 (86%)      3 (100%)                              
   Pancreas                                           (50)         (49)         (48)         (49)                                   
      Atrophy                                          7 (14%)      3 (6%)       4 (8%)      10 (20%)                               
      Hypertrophy                                      1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Duct, Cyst                                       1 (2%)                    1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Diverticulum                                                  1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                          2 (4%)       5 (10%)      2 (4%)       5 (10%)                               
   Stomach, Glandular                                 (50)         (48)         (47)         (48)                                   
      Inflammation, Suppurative                        1 (2%)                    2 (4%)       2 (4%)                                
      Necrosis                                         2 (4%)                    1 (2%)                                             
   Tooth                                              (2)          (1)          (1)                                                 
      Developmental Malformation                       1 (50%)                                                                      
      Inflammation                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Inflammation                                                  1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  46 (92%)     47 (94%)     43 (86%)     45 (90%)                               
      Atrium, Thrombosis                               1 (2%)                                                                       
      Ventricle, Thrombosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (48)                                   
      Hyperplasia                                      1 (2%)       1 (2%)       5 (10%)      2 (4%)                                
      Hypertrophy                                     35 (70%)     37 (76%)     31 (63%)     28 (58%)                               
      Capsule, Hyperplasia                                          1 (2%)                                                          
   Adrenal Medulla                                    (50)         (49)         (48)         (48)                                   
      Hyperplasia                                                                             1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (48)         (48)                                   
      Hyperplasia                                      9 (18%)      7 (14%)     10 (21%)      5 (10%)                               
   Pituitary Gland                                    (50)         (48)         (48)         (49)                                   
      Pars Distalis, Hyperplasia                       3 (6%)       4 (8%)       1 (2%)       2 (4%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (49)         (48)                                   
      Follicular Cell, Hyperplasia                     8 (16%)      9 (18%)      6 (12%)     13 (27%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Hyperplasia                                                                2 (4%)                                             
      Inflammation, Chronic                            2 (4%)       1 (2%)                    2 (4%)                                
      Mineralization                                                             1 (2%)                                             
      Spermatocele                                     2 (4%)                                                                       
   Penis                                                           (2)                                                              
      Inflammation                                                  1 (50%)                                                         
   Preputial Gland                                    (50)         (49)         (49)         (50)                                   
      Cyst                                             3 (6%)       3 (6%)       2 (4%)       6 (12%)                               
      Inflammation                                     3 (6%)                    1 (2%)       2 (4%)                                
   Prostate                                           (49)         (48)         (48)         (49)                                   
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (50)         (48)         (46)         (49)                                   
      Inflammation                                                               1 (2%)                                             
   Testes                                             (50)         (50)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                          4 (8%)       3 (6%)       5 (10%)      2 (4%)                                
      Degeneration                                                               1 (2%)                                             
      Inflammation, Focal, Granulomatous                                                      1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)                    1 (2%)                                
   Lymph Node, Bronchial                              (27)         (22)         (27)         (28)                                   
      Hyperplasia                                                                2 (7%)                                             
   Lymph Node, Mandibular                             (28)         (33)         (23)         (28)                                   
      Hyperplasia                                                                             1 (4%)                                
   Lymph Node, Mesenteric                             (50)         (46)         (46)         (47)                                   
      Angiectasis                                                   1 (2%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (4%)                    3 (6%)                                
   Lymph Node, Mediastinal                            (40)         (39)         (38)         (31)                                   
      Hematopoietic Cell Proliferation                              1 (3%)                                                          
      Hyperplasia                                      2 (5%)                    1 (3%)       1 (3%)                                
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 7 (14%)     12 (24%)     11 (22%)      9 (18%)                               
      Hyperplasia, Lymphoid                                         2 (4%)                                                          
   Thymus                                             (35)         (31)         (36)         (36)                                   
      Epithelial Cell, Hyperplasia                                               1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (48)         (49)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Prepuce, Inflammation, Chronic Active            3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Granulomatous                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                        1 (2%)       2 (4%)                                             
      Hyperostosis                                                  1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (48)                                   
      Hyperplasia                                      2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Lung                                               (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)       2 (4%)                                
      Infiltration Cellular, Histiocyte                4 (8%)       4 (8%)       5 (10%)      7 (14%)                               
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 5 (10%)      2 (4%)       2 (4%)       2 (4%)                                
      Mediastinum, Angiectasis                                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
   Nose                                               (50)         (49)         (49)         (50)                                   
      Inflammation, Suppurative                        7 (14%)     11 (22%)     27 (55%)     28 (56%)                               
      Glands, Hyperplasia                                          10 (20%)     48 (98%)     46 (92%)                               
      Glands, Metaplasia, Squamous                                  6 (12%)     35 (71%)     47 (94%)                               
      Lateral Wall, Metaplasia, Squamous                            9 (18%)     10 (20%)     20 (40%)                               
      Lateral Wall, Necrosis                                                     3 (6%)                                             
      Olfactory Epithelium, Atrophy                    3 (6%)      15 (31%)     49 (100%)    50 (100%)                              
      Olfactory Epithelium, Degeneration, Hyaline      2 (4%)       3 (6%)      21 (43%)     39 (78%)                               
      Olfactory Epithelium, Metaplasia                             12 (24%)     49 (100%)    50 (100%)                              
      Respiratory Epithelium, Degeneration, Hyaline    5 (10%)     18 (37%)     42 (86%)     45 (90%)                               
      Respiratory Epithelium, Hyperplasia, Polypoid                                           1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous                  2 (4%)      10 (20%)     20 (40%)                               
      Respiratory Epithelium, Necrosis                 1 (2%)                                 1 (2%)                                
      Respiratory Epithelium, Regeneration                          1 (2%)      13 (27%)     21 (42%)                               
   Trachea                                            (50)         (48)         (48)         (49)                                   
      Metaplasia, Squamous                             2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (49)         (49)                                   
      Cataract                                         2 (4%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic Active                     2 (4%)                                 1 (2%)                                
      Cornea, Dysplasia                                                          1 (2%)                                             
      Cornea, Hyperplasia                              1 (2%)                    2 (4%)       1 (2%)                                
      Cornea, Inflammation, Chronic Active                          1 (2%)                                                          
      Retina, Atrophy                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Cyst                                             1 (2%)       3 (6%)                                                          
      Hydronephrosis                                   2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic Active                     2 (4%)                    1 (2%)                                             
      Metaplasia, Osseous                              3 (6%)       4 (8%)                    4 (8%)                                
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     49 (98%)     48 (98%)     43 (88%)     47 (94%)                               
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Degeneration                                                 1 (2%)      48 (96%)                               
      Renal Tubule, Hyperplasia                        1 (2%)       3 (6%)                    3 (6%)                                
      Renal Tubule, Hypertrophy                                                  1 (2%)       1 (2%)                                
   Urinary Bladder                                    (50)         (47)         (47)         (50)                                   
      Inflammation, Chronic Active                     3 (6%)       1 (2%)                                                          
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05201-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:01:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Necrosis                                                                   1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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