TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 CHRONIC STUDY Facility: Battelle Northwest Chemical CAS #: 0098-00-0000 Lock Date: 01/26/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 11 12 15 8 Natural Death 5 3 2 2 Accidently Killed 1 1 Survivors Terminal Sacrifice 34 33 32 40 Other 1 Animals Examined Microscopically 50 49 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (49) (48) (50) Angiectasis 1 (2%) Inflammation 1 (2%) Gallbladder (43) (45) (47) (41) Degeneration, Hyaline 1 (2%) Inflammation, Suppurative 2 (4%) Intestine Large, Rectum (49) (45) (49) (48) Inflammation, Suppurative 1 (2%) Metaplasia, Squamous 1 (2%) Intestine Small, Duodenum (47) (46) (48) (48) Inflammation, Chronic 1 (2%) Necrosis 1 (2%) Epithelium, Hyperplasia 1 (2%) Intestine Small, Jejunum (45) (46) (48) (48) Peyer's Patch, Hyperplasia 1 (2%) Intestine Small, Ileum (45) (47) (48) (48) Peyer's Patch, Hyperplasia 1 (2%) 1 (2%) Liver (50) (49) (49) (49) Basophilic Focus 2 (4%) Clear Cell Focus 2 (4%) Degeneration, Fatty 1 (2%) 1 (2%) 1 (2%) 1 (2%) Eosinophilic Focus 14 (28%) 19 (39%) 20 (41%) 8 (16%) Hematopoietic Cell Proliferation 1 (2%) 5 (10%) 5 (10%) Infiltration Cellular, Mixed Cell 1 (2%) Inflammation, Chronic 4 (8%) 4 (8%) 1 (2%) Inflammation, Focal, Granulomatous 1 (2%) 2 (4%) Karyomegaly 1 (2%) Necrosis 2 (4%) 1 (2%) 4 (8%) 2 (4%) Pigmentation, Bile 1 (2%) Regeneration 1 (2%) Bile Duct, Cyst 1 (2%) Centrilobular, Necrosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Mesentery (15) (6) (11) (10) Angiectasis 1 (10%) Inflammation, Chronic 1 (7%) 1 (10%) Fat, Hemorrhage 1 (9%) 1 (10%) Fat, Necrosis 13 (87%) 6 (100%) 8 (73%) 7 (70%) Oral Mucosa (1) Pharyngeal, Hyperplasia 1 (100%) Pancreas (50) (48) (49) (49) Atrophy 7 (14%) 3 (6%) 5 (10%) 9 (18%) Cytoplasmic Alteration 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Hypertrophy 1 (2%) 2 (4%) 1 (2%) Inflammation, Chronic, Focal 1 (2%) 1 (2%) Duct, Cyst 1 (2%) Stomach, Forestomach (50) (48) (49) (49) Infiltration Cellular, Mast Cell 1 (2%) Inflammation, Suppurative 2 (4%) 1 (2%) Ulcer 3 (6%) 1 (2%) Epithelium, Hyperplasia 2 (4%) 8 (17%) 6 (12%) 3 (6%) Stomach, Glandular (50) (46) (49) (48) Inflammation, Suppurative 2 (4%) 2 (4%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Inflammation 1 (100%) Heart (50) (49) (49) (50) Cardiomyopathy 36 (72%) 40 (82%) 46 (94%) 42 (84%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (50) (49) Angiectasis 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 2 (4%) Hypertrophy 4 (8%) 1 (2%) 3 (6%) 3 (6%) Adrenal Medulla (48) (48) (49) (49) Hyperplasia 4 (8%) 1 (2%) 2 (4%) 4 (8%) Islets, Pancreatic (49) (48) (49) (49) Hyperplasia 2 (4%) 1 (2%) 2 (4%) Parathyroid Gland (32) (32) (29) (26) Hyperplasia 1 (3%) Pituitary Gland (48) (48) (48) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Angiectasis 1 (2%) Hemorrhage 1 (2%) Pars Distalis, Angiectasis 1 (2%) 1 (2%) Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 15 (31%) 17 (35%) 15 (31%) 17 (35%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (50) (49) (49) (49) Inflammation 1 (2%) Follicular Cell, Cyst 1 (2%) Follicular Cell, Hyperplasia 17 (34%) 21 (43%) 17 (35%) 30 (61%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (49) (48) (49) Angiectasis 2 (4%) 1 (2%) Atrophy 4 (8%) 3 (6%) 1 (2%) 2 (4%) Cyst 14 (28%) 14 (29%) 18 (38%) 15 (31%) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Mononuclear Cell 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) Thrombosis 1 (2%) Corpus Luteum, Hemorrhage 1 (2%) Corpus Luteum, Hyperplasia 1 (2%) Germinal Epithelium, Hyperplasia 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) 2 (4%) 1 (2%) Uterus (50) (49) (49) (49) Angiectasis 3 (6%) 4 (8%) 2 (4%) Hemorrhage 1 (2%) 1 (2%) Hydrometra 5 (10%) 5 (10%) 4 (8%) 3 (6%) Hyperplasia, Cystic 4 (8%) 3 (6%) 2 (4%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) Thrombosis 1 (2%) 2 (4%) 1 (2%) Endometrium, Hyperplasia 1 (2%) 1 (2%) Endometrium, Metaplasia 1 (2%) Myometrium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (49) (49) (49) Hyperplasia 1 (2%) 1 (2%) Lymph Node (6) (4) (5) (4) Angiectasis 4 (67%) 3 (75%) 2 (40%) Necrosis 1 (17%) Renal, Hyperplasia 1 (25%) 1 (20%) Lymph Node, Bronchial (33) (27) (30) (37) Hyperplasia 1 (3%) 1 (4%) 1 (3%) 2 (5%) Lymph Node, Mandibular (36) (40) (43) (40) Hyperplasia 1 (3%) 2 (5%) 2 (5%) Infiltration Cellular, Mast Cell 1 (2%) Lymph Node, Mesenteric (48) (47) (47) (46) Angiectasis 1 (2%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 2 (4%) 1 (2%) 1 (2%) Lymph Node, Mediastinal (41) (34) (40) (40) Hyperplasia 4 (10%) 1 (3%) 3 (8%) 2 (5%) Spleen (50) (48) (49) (49) Hematopoietic Cell Proliferation 11 (22%) 11 (23%) 12 (24%) 17 (35%) Hyperplasia, Lymphoid 8 (16%) 8 (17%) 4 (8%) 5 (10%) Thymus (42) (40) (46) (38) Angiectasis 1 (3%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (49) (49) (50) Hyperplasia 2 (4%) 1 (2%) 2 (4%) Skin (50) (49) (49) (50) Hemorrhage 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%) Subcutaneous Tissue, Angiectasis 1 (2%) 1 (2%) Subcutaneous Tissue, Hemorrhage 1 (2%) 1 (2%) Subcutaneous Tissue, Inflammation, Focal, Granulomatous 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (49) (50) (50) Fibrous Osteodystrophy 16 (32%) 19 (39%) 15 (30%) 22 (44%) Fracture 1 (2%) Hyperostosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (49) (49) Gliosis 1 (2%) Necrosis 2 (4%) 1 (2%) Meninges, Infiltration Cellular, Mononuclear Cell 4 (8%) 4 (8%) 2 (4%) 4 (8%) Peripheral Nerve (1) Degeneration 1 (100%) Spinal Cord (2) (2) (1) Degeneration 1 (50%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (49) (50) (49) Hyperplasia 5 (10%) 9 (18%) 3 (6%) 5 (10%) Inflammation, Suppurative 3 (6%) 1 (2%) Epiglottis, Metaplasia, Squamous 1 (2%) Lung (50) (49) (49) (50) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Histiocyte 3 (6%) 5 (10%) 2 (4%) 3 (6%) Inflammation, Chronic, Focal 1 (2%) 1 (2%) Pigmentation, Hemosiderin 1 (2%) Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%) Mediastinum, Inflammation, Chronic 1 (2%) 1 (2%) Nose (50) (48) (49) (50) Inflammation, Suppurative 5 (10%) 12 (25%) 25 (51%) 42 (84%) Glands, Hyperplasia 33 (69%) 46 (94%) 47 (94%) Glands, Metaplasia, Squamous 1 (2%) 1 (2%) 34 (69%) 46 (92%) Lateral Wall, Metaplasia, Squamous 3 (6%) 14 (29%) 16 (33%) 36 (72%) Lateral Wall, Necrosis 4 (8%) 1 (2%) Olfactory Epithelium, Atrophy 2 (4%) 35 (73%) 49 (100%) 50 (100%) Olfactory Epithelium, Degeneration, Hyaline 7 (14%) 14 (29%) 28 (57%) 45 (90%) Olfactory Epithelium, Metaplasia 31 (65%) 49 (100%) 49 (98%) Respiratory Epithelium, Degeneration, Hyaline 19 (38%) 44 (92%) 49 (100%) 48 (96%) Respiratory Epithelium, Hyperplasia, Polypoid 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 9 (19%) 21 (43%) 39 (78%) Respiratory Epithelium, Necrosis 2 (4%) 3 (6%) Respiratory Epithelium, Regeneration 9 (18%) 13 (26%) Trachea (50) (48) (49) (48) Metaplasia, Squamous 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (49) (49) (49) (50) Cataract 2 (4%) 1 (2%) 1 (2%) Inflammation, Acute 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 2 (4%) Cornea, Degeneration 3 (6%) 1 (2%) 4 (8%) 26 (52%) Cornea, Fibrosis 1 (2%) Cornea, Hyperplasia 2 (4%) 4 (8%) 7 (14%) Cornea, Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (48) (49) (49) Metaplasia, Osseous 1 (2%) 3 (6%) 2 (4%) 4 (8%) Mineralization 1 (2%) Nephropathy 41 (82%) 35 (73%) 40 (82%) 39 (80%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 11 10 14 8 Natural Death 5 4 6 4 Survivors Terminal Sacrifice 34 36 30 38 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (45) (42) (42) (43) Degeneration, Hyaline 1 (2%) Epithelium, Hyperplasia 1 (2%) 1 (2%) Intestine Large, Rectum (48) (47) (46) (46) Anus, Inflammation, Chronic Active 1 (2%) Intestine Large, Cecum (48) (47) (46) (48) Serosa, Inflammation, Chronic 1 (2%) Intestine Small, Duodenum (48) (48) (46) (47) Peyer's Patch, Hyperplasia 1 (2%) Intestine Small, Ileum (46) (48) (46) (47) Peyer's Patch, Hyperplasia 1 (2%) Liver (50) (50) (49) (50) Angiectasis 2 (4%) Basophilic Focus 5 (10%) Clear Cell Focus 3 (6%) 3 (6%) 1 (2%) Degeneration, Cystic 1 (2%) Degeneration, Fatty 5 (10%) 1 (2%) 1 (2%) Eosinophilic Focus 13 (26%) 18 (36%) 12 (24%) 14 (28%) Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%) Necrosis 2 (4%) 4 (8%) 6 (12%) 2 (4%) Vacuolization Cytoplasmic 1 (2%) 3 (6%) Bile Duct, Cyst 1 (2%) 1 (2%) 1 (2%) Bile Duct, Hyperplasia 1 (2%) Centrilobular, Degeneration 1 (2%) Centrilobular, Necrosis 1 (2%) Mesentery (7) (4) (7) (3) Fat, Necrosis 7 (100%) 4 (100%) 6 (86%) 3 (100%) Pancreas (50) (49) (48) (49) Atrophy 7 (14%) 3 (6%) 4 (8%) 10 (20%) Hypertrophy 1 (2%) 2 (4%) Inflammation, Chronic, Focal 1 (2%) Duct, Cyst 1 (2%) 1 (2%) Salivary Glands (50) (49) (49) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Hyperplasia 1 (2%) Inflammation, Chronic 1 (2%) Duct, Hyperplasia 1 (2%) Stomach, Forestomach (50) (49) (50) (50) Diverticulum 1 (2%) Hyperkeratosis 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Ulcer 1 (2%) Epithelium, Hyperplasia 2 (4%) 5 (10%) 2 (4%) 5 (10%) Stomach, Glandular (50) (48) (47) (48) Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%) Necrosis 2 (4%) 1 (2%) Tooth (2) (1) (1) Developmental Malformation 1 (50%) Inflammation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (1) Inflammation 1 (100%) Heart (50) (50) (50) (50) Cardiomyopathy 46 (92%) 47 (94%) 43 (86%) 45 (90%) Atrium, Thrombosis 1 (2%) Ventricle, Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (49) (48) Hyperplasia 1 (2%) 1 (2%) 5 (10%) 2 (4%) Hypertrophy 35 (70%) 37 (76%) 31 (63%) 28 (58%) Capsule, Hyperplasia 1 (2%) Adrenal Medulla (50) (49) (48) (48) Hyperplasia 1 (2%) Islets, Pancreatic (50) (49) (48) (48) Hyperplasia 9 (18%) 7 (14%) 10 (21%) 5 (10%) Pituitary Gland (50) (48) (48) (49) Pars Distalis, Hyperplasia 3 (6%) 4 (8%) 1 (2%) 2 (4%) Pars Intermedia, Hyperplasia 1 (2%) Thyroid Gland (50) (49) (49) (48) Follicular Cell, Hyperplasia 8 (16%) 9 (18%) 6 (12%) 13 (27%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (49) (50) Hyperplasia 2 (4%) Inflammation, Chronic 2 (4%) 1 (2%) 2 (4%) Mineralization 1 (2%) Spermatocele 2 (4%) Penis (2) Inflammation 1 (50%) Preputial Gland (50) (49) (49) (50) Cyst 3 (6%) 3 (6%) 2 (4%) 6 (12%) Inflammation 3 (6%) 1 (2%) 2 (4%) Prostate (49) (48) (48) (49) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) Seminal Vesicle (50) (48) (46) (49) Inflammation 1 (2%) Testes (50) (50) (49) (50) Angiectasis 1 (2%) Atrophy 4 (8%) 3 (6%) 5 (10%) 2 (4%) Degeneration 1 (2%) Inflammation, Focal, Granulomatous 1 (2%) Mineralization 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (49) (49) (50) Hyperplasia 2 (4%) 2 (4%) 1 (2%) Lymph Node, Bronchial (27) (22) (27) (28) Hyperplasia 2 (7%) Lymph Node, Mandibular (28) (33) (23) (28) Hyperplasia 1 (4%) Lymph Node, Mesenteric (50) (46) (46) (47) Angiectasis 1 (2%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hyperplasia 1 (2%) 2 (4%) 3 (6%) Lymph Node, Mediastinal (40) (39) (38) (31) Hematopoietic Cell Proliferation 1 (3%) Hyperplasia 2 (5%) 1 (3%) 1 (3%) Spleen (50) (49) (49) (50) Angiectasis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 7 (14%) 12 (24%) 11 (22%) 9 (18%) Hyperplasia, Lymphoid 2 (4%) Thymus (35) (31) (36) (36) Epithelial Cell, Hyperplasia 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (48) (49) Cyst Epithelial Inclusion 1 (2%) Inflammation, Chronic 2 (4%) Inflammation, Chronic Active 1 (2%) Mineralization 1 (2%) Prepuce, Inflammation, Chronic Active 3 (6%) 2 (4%) 3 (6%) 2 (4%) Subcutaneous Tissue, Inflammation, Chronic Active 2 (4%) 1 (2%) Subcutaneous Tissue, Inflammation, Focal, Granulomatous 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 1 (2%) 2 (4%) Hyperostosis 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) Cyst Epithelial Inclusion 1 (2%) Meninges, Infiltration Cellular, Mononuclear Cell 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (49) (49) (48) Hyperplasia 2 (4%) 1 (2%) 2 (4%) 1 (2%) Inflammation, Suppurative 1 (2%) 1 (2%) Lung (50) (50) (49) (50) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 1 (2%) 1 (2%) 2 (4%) Infiltration Cellular, Histiocyte 4 (8%) 4 (8%) 5 (10%) 7 (14%) Inflammation, Chronic, Focal 1 (2%) Alveolar Epithelium, Hyperplasia 5 (10%) 2 (4%) 2 (4%) 2 (4%) Mediastinum, Angiectasis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Nose (50) (49) (49) (50) Inflammation, Suppurative 7 (14%) 11 (22%) 27 (55%) 28 (56%) Glands, Hyperplasia 10 (20%) 48 (98%) 46 (92%) Glands, Metaplasia, Squamous 6 (12%) 35 (71%) 47 (94%) Lateral Wall, Metaplasia, Squamous 9 (18%) 10 (20%) 20 (40%) Lateral Wall, Necrosis 3 (6%) Olfactory Epithelium, Atrophy 3 (6%) 15 (31%) 49 (100%) 50 (100%) Olfactory Epithelium, Degeneration, Hyaline 2 (4%) 3 (6%) 21 (43%) 39 (78%) Olfactory Epithelium, Metaplasia 12 (24%) 49 (100%) 50 (100%) Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 18 (37%) 42 (86%) 45 (90%) Respiratory Epithelium, Hyperplasia, Polypoid 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 10 (20%) 20 (40%) Respiratory Epithelium, Necrosis 1 (2%) 1 (2%) Respiratory Epithelium, Regeneration 1 (2%) 13 (27%) 21 (42%) Trachea (50) (48) (48) (49) Metaplasia, Squamous 2 (4%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (48) (49) (49) Cataract 2 (4%) 1 (2%) 3 (6%) Inflammation, Chronic Active 2 (4%) 1 (2%) Cornea, Dysplasia 1 (2%) Cornea, Hyperplasia 1 (2%) 2 (4%) 1 (2%) Cornea, Inflammation, Chronic Active 1 (2%) Retina, Atrophy 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (49) (50) Amyloid Deposition 1 (2%) Cyst 1 (2%) 3 (6%) Hydronephrosis 2 (4%) 2 (4%) 1 (2%) 2 (4%) Inflammation, Chronic Active 2 (4%) 1 (2%) Metaplasia, Osseous 3 (6%) 4 (8%) 4 (8%) Mineralization 1 (2%) Nephropathy 49 (98%) 48 (98%) 43 (88%) 47 (94%) Papilla, Necrosis 1 (2%) Renal Tubule, Degeneration 1 (2%) 48 (96%) Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 3 (6%) Renal Tubule, Hypertrophy 1 (2%) 1 (2%) Urinary Bladder (50) (47) (47) (50) Inflammation, Chronic Active 3 (6%) 1 (2%) Inflammation, Suppurative 1 (2%) Mineralization 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:01:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Necrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------