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TDMS Study 05201-06 Pathology Tables

NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20

                                                         CHRONIC STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           12           15            8                                     
    Natural Death                                      5            3            2            2                                     
    Accidently Killed                                               1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           33           32           40                                     
  Other                                                             1                                                               
  Animals Examined Microscopically                    50           49           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (45)         (49)         (48)                                   
      Anus, Squamous Cell Carcinoma                    1 (2%)                                                                       
   Intestine Small, Duodenum                          (47)         (46)         (48)         (48)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (45)         (46)         (48)         (48)                                   
   Intestine Small, Ileum                             (45)         (47)         (48)         (48)                                   
   Liver                                              (50)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatocellular Carcinoma                         8 (16%)     12 (24%)      5 (10%)      6 (12%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       3 (6%)                    2 (4%)                                
      Hepatocellular Adenoma                           5 (10%)      5 (10%)      9 (18%)      5 (10%)                               
      Hepatocellular Adenoma, Multiple                 2 (4%)       2 (4%)                                                          
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                          (15)         (6)          (11)         (10)                                   
      Hemangiosarcoma                                                            1 (9%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (9%)                                             
      Histiocytic Sarcoma                              1 (7%)                                                                       
      Sarcoma, Metastatic, Skin                                                               1 (10%)                               
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Stomach, Forestomach                               (50)         (48)         (49)         (49)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    3 (6%)                                             
   Stomach, Glandular                                 (50)         (46)         (49)         (48)                                   
   Tooth                                                                        (2)                                                 
      Adamantinoma Malignant                                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (49)         (50)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (49)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Capsule, Adenoma                                              2 (4%)                    1 (2%)                                
   Adrenal Medulla                                    (48)         (48)         (49)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Islets, Pancreatic                                 (49)         (48)         (49)         (49)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (48)         (48)         (48)         (49)                                   
      Pars Distalis, Adenoma                           7 (15%)      7 (15%)      4 (8%)       1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (49)         (49)                                   
      Bilateral, Follicular Cell, Adenoma                                        1 (2%)                                             
      Follicular Cell, Adenoma                         3 (6%)       1 (2%)       2 (4%)       5 (10%)                               
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (43)         (41)         (31)         (41)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Ovary                                              (50)         (49)         (48)         (49)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Cystadenoma                                      2 (4%)       1 (2%)       3 (6%)       2 (4%)                                
      Granulosa Cell Tumor Benign                                                2 (4%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Luteoma                                          1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Yolk Sac Carcinoma                                                         1 (2%)                                             
   Uterus                                             (50)         (49)         (49)         (49)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                    1 (2%)                                
   Lymph Node                                         (6)          (4)          (5)          (4)                                    
   Lymph Node, Bronchial                              (33)         (27)         (30)         (37)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (3%)       1 (4%)       1 (3%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (3%)                                             
   Lymph Node, Mandibular                             (36)         (40)         (43)         (40)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (3%)                                                          
   Lymph Node, Mesenteric                             (48)         (47)         (47)         (46)                                   
   Lymph Node, Mediastinal                            (41)         (34)         (40)         (40)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)       1 (3%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (3%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (3%)                                             
   Spleen                                             (50)         (48)         (49)         (49)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (42)         (40)         (46)         (38)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (50)                                   
      Carcinoma                                                     2 (4%)       1 (2%)                                             
   Skin                                               (50)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangioma, Multiple                                  1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    2 (4%)       1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma, Multiple                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Bone Marrow         1 (2%)                                                                       
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                 (1)          (1)          (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
      Sarcoma, Metastatic, Skin                                                               1 (100%)                              
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (49)         (49)                                   
      Meninges, Histiocytic Sarcoma                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)       4 (8%)       8 (16%)                                            
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       3 (6%)       3 (6%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                        2 (4%)                    1 (2%)                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)                    3 (6%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              2 (4%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (2%)       1 (2%)                                             
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
      Mediastinum, Sarcoma, Metastatic, Skin                                                  1 (2%)                                
   Nose                                               (50)         (48)         (49)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (49)         (49)         (50)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Harderian Gland                                    (2)          (5)          (6)          (6)                                    
      Adenoma                                          2 (100%)     2 (40%)      5 (83%)      5 (83%)                               
      Carcinoma                                                     2 (40%)                   1 (17%)                               
                                                             Page   5                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - cont                                                                                                        
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (49)         (49)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Urinary Bladder                                    (49)         (45)         (49)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)       1 (2%)       2 (4%)                                             
      Lymphoma Malignant                               6 (12%)      3 (6%)       5 (10%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          37          39          36                                       
     Total Primary Neoplasms                           58          60          70          51                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          23          29          21                                       
     Total Benign Neoplasms                            31          29          43          26                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          25          23          22                                       
     Total Malignant Neoplasms                         27          31          27          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           4           4           6                                       
     Total Metastatic Neoplasm                          5          10          26           8                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11           10           14            8                                     
    Natural Death                                      5            4            6            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           36           30           38                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (48)         (48)         (46)         (47)                                   
   Intestine Small, Jejunum                           (47)         (47)         (45)         (47)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (46)         (48)         (46)         (47)                                   
   Liver                                              (50)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                               5 (10%)                   3 (6%)                                
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                        13 (26%)     17 (34%)     11 (22%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple               2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Hepatocellular Adenoma                           7 (14%)     12 (24%)      5 (10%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                 6 (12%)      1 (2%)       5 (10%)      2 (4%)                                
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
   Mesentery                                          (7)          (4)          (7)          (3)                                    
      Hemangioma                                                                 1 (14%)                                            
   Oral Mucosa                                        (1)                                                                           
      Pharyngeal, Squamous Cell Carcinoma              1 (100%)                                                                     
   Pancreas                                           (50)         (49)         (48)         (49)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (47)         (48)                                   
      Sarcoma                                                                    1 (2%)                                             
   Tooth                                              (2)          (1)          (1)                                                 
      Odontoma                                         1 (50%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (48)                                   
      Adenoma                                          2 (4%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Capsule, Adenoma                                 4 (8%)       2 (4%)                    1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (48)         (48)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (48)         (48)                                   
      Adenoma                                          2 (4%)       1 (2%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (48)         (48)         (49)                                   
      Schwannoma Malignant, Metastatic, Nose           1 (2%)                                                                       
      Pars Distalis, Adenoma                                                     1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (49)         (48)                                   
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Leiomyoma                                        1 (2%)                                                                       
   Testes                                             (50)         (50)         (49)         (50)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)          (2)          (1)          (1)                                    
   Lymph Node, Bronchial                              (27)         (22)         (27)         (28)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (4%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (5%)                    1 (4%)                                
   Lymph Node, Mandibular                             (28)         (33)         (23)         (28)                                   
   Lymph Node, Mesenteric                             (50)         (46)         (46)         (47)                                   
   Lymph Node, Mediastinal                            (40)         (39)         (38)         (31)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Thymus                                             (35)         (31)         (36)         (36)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (48)         (49)                                   
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Maxilla, Hemangiosarcoma                         1 (2%)                                                                       
   Skeletal Muscle                                                              (1)          (1)                                    
      Hemangiosarcoma                                                                         1 (100%)                              
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Meningioma Benign                                                                       1 (2%)                                
      Meninges, Schwannoma Malignant, Metastatic,                                                                                   
           Nose                                        1 (2%)                                                                       
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                    14 (28%)     15 (30%)      9 (18%)     12 (24%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       7 (14%)      7 (14%)      8 (16%)                               
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       4 (8%)       3 (6%)       4 (8%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                    1 (2%)                                
   Nose                                               (50)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Nose           1 (2%)                                                                       
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                                                             Page  10                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
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         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (4)          (5)          (3)                                    
      Adenoma                                          3 (75%)      3 (75%)      5 (100%)     2 (67%)                               
      Carcinoma                                        1 (25%)                                1 (33%)                               
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Renal Tubule, Adenoma                                                                   2 (4%)                                
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
      Renal Tubule, Carcinoma, Multiple                                                       1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Lymphoma Malignant                               3 (6%)       3 (6%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05201-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:17:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          44          41          39                                       
     Total Primary Neoplasms                           70          76          61          66                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          31          25          29                                       
     Total Benign Neoplasms                            43          40          30          34                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          30          26          25                                       
     Total Malignant Neoplasms                         27          36          31          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           5           5           7                                       
     Total Metastatic Neoplasm                          7          10           6          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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