TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
CHRONIC STUDY
Facility: Battelle Northwest
Chemical CAS #: 0098-00-0000
Lock Date: 01/26/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 12 15 8
Natural Death 5 3 2 2
Accidently Killed 1 1
Survivors
Terminal Sacrifice 34 33 32 40
Other 1
Animals Examined Microscopically 50 49 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (45) (49) (48)
Anus, Squamous Cell Carcinoma 1 (2%)
Intestine Small, Duodenum (47) (46) (48) (48)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (45) (46) (48) (48)
Intestine Small, Ileum (45) (47) (48) (48)
Liver (50) (49) (49) (49)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 8 (16%) 12 (24%) 5 (10%) 6 (12%)
Hepatocellular Carcinoma, Multiple 1 (2%) 3 (6%) 2 (4%)
Hepatocellular Adenoma 5 (10%) 5 (10%) 9 (18%) 5 (10%)
Hepatocellular Adenoma, Multiple 2 (4%) 2 (4%)
Hepatocholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (15) (6) (11) (10)
Hemangiosarcoma 1 (9%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (9%)
Histiocytic Sarcoma 1 (7%)
Sarcoma, Metastatic, Skin 1 (10%)
Pancreas (50) (48) (49) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Salivary Glands (50) (49) (49) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Stomach, Forestomach (50) (48) (49) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 3 (6%)
Stomach, Glandular (50) (46) (49) (48)
Tooth (2)
Adamantinoma Malignant 1 (50%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (49) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (50) (49)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Capsule, Adenoma 2 (4%) 1 (2%)
Adrenal Medulla (48) (48) (49) (49)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Islets, Pancreatic (49) (48) (49) (49)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (48) (48) (48) (49)
Pars Distalis, Adenoma 7 (15%) 7 (15%) 4 (8%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (49) (49)
Bilateral, Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma 3 (6%) 1 (2%) 2 (4%) 5 (10%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (41) (31) (41)
Histiocytic Sarcoma 1 (2%)
Ovary (50) (49) (48) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Cystadenoma 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Granulosa Cell Tumor Benign 2 (4%)
Histiocytic Sarcoma 2 (4%)
Luteoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Yolk Sac Carcinoma 1 (2%)
Uterus (50) (49) (49) (49)
Adenocarcinoma 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
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NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (49)
Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%)
Lymph Node (6) (4) (5) (4)
Lymph Node, Bronchial (33) (27) (30) (37)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%) 1 (4%) 1 (3%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (3%)
Lymph Node, Mandibular (36) (40) (43) (40)
Carcinoma, Metastatic, Harderian Gland 1 (3%)
Lymph Node, Mesenteric (48) (47) (47) (46)
Lymph Node, Mediastinal (41) (34) (40) (40)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%) 1 (3%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (3%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (3%)
Spleen (50) (48) (49) (49)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Thymus (42) (40) (46) (38)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (49) (50)
Carcinoma 2 (4%) 1 (2%)
Skin (50) (49) (49) (50)
Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangioma, Multiple 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50)
Hemangiosarcoma, Metastatic, Bone Marrow 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Sarcoma, Metastatic, Skin 1 (100%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49) (49)
Meninges, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (49) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 4 (8%) 8 (16%)
Alveolar/Bronchiolar Carcinoma 4 (8%) 3 (6%) 3 (6%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 2 (4%) 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 1 (2%) 3 (6%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%) 1 (2%)
Mediastinum, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (2%)
Mediastinum, Sarcoma, Metastatic, Skin 1 (2%)
Nose (50) (48) (49) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (49) (49) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Harderian Gland (2) (5) (6) (6)
Adenoma 2 (100%) 2 (40%) 5 (83%) 5 (83%)
Carcinoma 2 (40%) 1 (17%)
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NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont
Sarcoma, Metastatic, Uncertain Primary Site 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (49) (49)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Urinary Bladder (49) (45) (49) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(49) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%) 2 (4%)
Lymphoma Malignant 6 (12%) 3 (6%) 5 (10%) 8 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 36 37 39 36
Total Primary Neoplasms 58 60 70 51
Total Animals with Benign Neoplasms 23 23 29 21
Total Benign Neoplasms 31 29 43 26
Total Animals with Malignant Neoplasms 20 25 23 22
Total Malignant Neoplasms 27 31 27 25
Total Animals with Metastatic Neoplasms 5 4 4 6
Total Metastatic Neoplasm 5 10 26 8
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 10 14 8
Natural Death 5 4 6 4
Survivors
Terminal Sacrifice 34 36 30 38
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (48) (48) (46) (47)
Intestine Small, Jejunum (47) (47) (45) (47)
Carcinoma 1 (2%) 1 (2%)
Intestine Small, Ileum (46) (48) (46) (47)
Liver (50) (50) (49) (50)
Hemangiosarcoma 5 (10%) 3 (6%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 13 (26%) 17 (34%) 11 (22%) 12 (24%)
Hepatocellular Carcinoma, Multiple 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Hepatocellular Adenoma 7 (14%) 12 (24%) 5 (10%) 11 (22%)
Hepatocellular Adenoma, Multiple 6 (12%) 1 (2%) 5 (10%) 2 (4%)
Hepatocholangiocarcinoma 1 (2%)
Mesentery (7) (4) (7) (3)
Hemangioma 1 (14%)
Oral Mucosa (1)
Pharyngeal, Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (49) (48) (49)
Hemangiosarcoma 1 (2%)
Stomach, Forestomach (50) (49) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (48) (47) (48)
Sarcoma 1 (2%)
Tooth (2) (1) (1)
Odontoma 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (48)
Adenoma 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Capsule, Adenoma 4 (8%) 2 (4%) 1 (2%)
Adrenal Medulla (50) (49) (48) (48)
Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (50) (49) (48) (48)
Adenoma 2 (4%) 1 (2%) 2 (4%)
Pituitary Gland (50) (48) (48) (49)
Schwannoma Malignant, Metastatic, Nose 1 (2%)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (50) (49) (49) (48)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50)
Leiomyoma 1 (2%)
Testes (50) (50) (49) (50)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2) (2) (1) (1)
Lymph Node, Bronchial (27) (22) (27) (28)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (4%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (5%) 1 (4%)
Lymph Node, Mandibular (28) (33) (23) (28)
Lymph Node, Mesenteric (50) (46) (46) (47)
Lymph Node, Mediastinal (40) (39) (38) (31)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
Spleen (50) (49) (49) (50)
Hemangiosarcoma 1 (2%)
Thymus (35) (31) (36) (36)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (3%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (48) (49)
Hemangioma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Maxilla, Hemangiosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50)
Meningioma Benign 1 (2%)
Meninges, Schwannoma Malignant, Metastatic,
Nose 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 14 (28%) 15 (30%) 9 (18%) 12 (24%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 7 (14%) 7 (14%) 8 (16%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 4 (8%) 3 (6%) 4 (8%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinum, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (2%) 1 (2%)
Nose (50) (49) (49) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Schwannoma Malignant, Metastatic, Nose 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (4) (5) (3)
Adenoma 3 (75%) 3 (75%) 5 (100%) 2 (67%)
Carcinoma 1 (25%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Renal Tubule, Adenoma 2 (4%)
Renal Tubule, Carcinoma 1 (2%)
Renal Tubule, Carcinoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Lymphoma Malignant 3 (6%) 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05201-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:17:20
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2.0 PPM 8.0 PPM 32.0 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 44 41 39
Total Primary Neoplasms 70 76 61 66
Total Animals with Benign Neoplasms 31 31 25 29
Total Benign Neoplasms 43 40 30 34
Total Animals with Malignant Neoplasms 22 30 26 25
Total Malignant Neoplasms 27 36 31 32
Total Animals with Metastatic Neoplasms 4 5 5 7
Total Metastatic Neoplasm 7 10 6 11
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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