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TDMS Study 05201-06 Pathology Tables

NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45

                                                         CHRONIC STUDY




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1

NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|             
                                           | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                                                                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  M  +  +  A  +  +  +  M  +  +|             
      Degeneration, Hyaline                |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   | X                          X     X        X        X                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal, Granulomatous   |       3                                                                  |             
      Necrosis                             |                                                       1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +        +  +                    +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |    2                    4  3           3                    2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                        1  1      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic, Focal         |                                              4                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  1  1  1        1  1     1     1  1        1  2  1  1  1  1  1  1|             
      Mineralization                       |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |       1                 1                       1                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +|             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  M  +  +  +  +  +  M  M  +  +  M  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|             
                                           | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          1           1  4                    4              2  2     1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Follicular Cell, Cyst                |                         2                                                |             
      Follicular Cell, Hyperplasia         |    1     2     1           2     1  1        2     1     1           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            2                                             |             
      Cyst                                 |          1     1        3     2  2              2  2                 2  2|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Corpus Luteum, Hemorrhage            |                                                                          |             
      Germinal Epithelium, Hyperplasia     |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                           1                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                             2                                          |             
      Hydrometra                           |                                  3                                       |             
      Hyperplasia, Cystic                  |                            3                    4     2                  |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  I  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  +  M  M  +  M  M  +  M  +  M  +  M  +  +  +|             
      Hyperplasia                          |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |             4        4                       3                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3                 2  2           2  2        2        2            |             
      Hyperplasia, Lymphoid                |                      2           2                 2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|             
                                           | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Angiectasis     |                                              3                           |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1  2  1  1  1                                   2        2     3      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |          1                       1                                2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                                1   |             
      Epiglottis, Metaplasia, Squamous     |             1                                                            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 4     3                                                                  |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2                                                     1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2           1                                                |             
      Glands, Metaplasia, Squamous         |                                                                          |             
      Lateral Wall, Metaplasia, Squamous   |                                                                          |             
      Olfactory Epithelium, Atrophy        |             1           1                                                |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    1                    1        2                                   2   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1  1     2        2  1        1     1           1                 1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pleura                                  |       +                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|             
                                           | 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Degeneration                 |    1                                                                    1|             
      Cornea, Fibrosis                     |       2                                                                  |             
      Cornea, Hyperplasia                  |    1  1                                                                  |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1  1     1  1     1  1  1  1  2        1  1  1  1  1  1  2  1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3|            |
                                           | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  43        |
      Degeneration, Hyaline                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                         2                                                |      1  2.0|
      Eosinophilic Focus                   | X           X           X  X  X  X  X  X        X                        |     14     |
      Hematopoietic Cell Proliferation     |    4                                                                     |      1  4.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
      Necrosis                             |                   1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +        +                                +  +                     |  15        |
      Inflammation, Chronic                |                                                    4                     |      1  4.0|
      Fat, Necrosis                        | 4     4        1                                   4                     |     13  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                               1  1     2                       1         |      7  1.4|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Hypertrophy                          |             1                                                            |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                   1                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1     1        1  1  2  1  1  2  1  1  1     1  1     1  1     1  1|     36  1.1|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy                          |                                                                1         |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3|            |
                                           | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |             1                             1                 1            |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Cyst                  |                                        2                                 |      1  2.0|
      Pars Distalis, Hyperplasia           | 1           2              1           2           1              1  3  2|     15  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                   1      |      1  1.0|
      Follicular Cell, Cyst                |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         | 1              1                 1  1  1              2           1      |     17  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  I  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        2                       2        2|      4  2.0|
      Cyst                                 |       2  2                    1     1                    2               |     14  1.8|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                           2                              |      1  2.0|
      Corpus Luteum, Hemorrhage            |                                  2                                       |      1  2.0|
      Germinal Epithelium, Hyperplasia     |                                                                4         |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             3            |      3  2.3|
      Hydrometra                           |                      3     2           3                 2               |      5  2.6|
      Hyperplasia, Cystic                  |                                                             2            |      4  2.8|
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
      Thrombosis                           |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +  +                    +  +                    +  +|   6        |
      Angiectasis                          |                      4  3                                            3  4|      4  3.5|
      Necrosis                             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  +  M  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3|            |
                                           | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|  36        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  M  +  +  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +|  41        |
      Hyperplasia                          |                3                                                         |      4  3.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                            2        2                 2  3               |     11  2.2|
      Hyperplasia, Lymphoid                |                2                 2     2                       2        2|      8  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                       4                  |      1  4.0|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      1  3.0|
      Subcutaneous Tissue, Hemorrhage      |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                      2  4        1                    1        1  2  3  2|     16  1.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                       1                  |      4  1.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                           +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1                 2                                                  3   |      5  1.6|
      Epiglottis, Metaplasia, Squamous     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          1                                                               |      3  2.7|
      Inflammation, Chronic, Focal         |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |          1                                               1     1         |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3|            |
                                           | 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Glands, Metaplasia, Squamous         |                                           1                              |      1  1.0|
      Lateral Wall, Metaplasia, Squamous   |          1                                               1     1         |      3  1.0|
      Olfactory Epithelium, Atrophy        |                                                                          |      2  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |             1                 1  1                                       |      7  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    1  1     2                 2  2     2  2     1                    1  2|     19  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |       1                                                        1         |      2  1.0|
      Cornea, Degeneration                 |                      1                                                   |      3  1.0|
      Cornea, Fibrosis                     |                                                                          |      1  2.0|
      Cornea, Hyperplasia                  |                                                                          |      2  1.0|
      Cornea, Inflammation, Chronic Active |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +              +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Osseous                  |                      1                                                   |      1  1.0|
      Nephropathy                          | 1  1  1     1  1     1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1|     41  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|             
                                           | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |    X           X  X     X        X                 X           X  X     X|             
      Inflammation, Chronic                |                                                 3           2            |             
      Inflammation, Focal, Granulomatous   | 1                                                                        |             
      Necrosis                             |          2                                                               |             
      Pigmentation, Bile                   |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +                       +         |             
      Fat, Necrosis                        |                                     3  2                       2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |          1                                                               |             
      Cytoplasmic Alteration               |                   1                                                      |             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Suppurative            |                1                                                         |             
      Ulcer                                |                                                                         1|             
      Epithelium, Hyperplasia              |                2                                               1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +     A|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
      Inflammation                         |                3                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy                       | 2  1  1  1  1  1  1     1     1  1  1  1  1  1  1     1  1     2  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|             
                                           | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                     1              1                     |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  M  M     M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           | 1  1  1           1  1        1  1                 1                    2|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Follicular Cell, Hyperplasia         |    2  1        1        1     1  1        1  3        1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  M  +  +  +     +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                   4      |             
      Atrophy                              | 4                 2                                      4               |             
      Cyst                                 | 4  3  4                                         4                        |             
      Hemorrhage                           |                                                 4                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thrombosis                           |                                                                   4      |             
      Corpus Luteum, Hyperplasia           |                                           3                              |             
      Interstitial Cell, Hyperplasia       |                                              2                    4      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                         4                                               2|             
      Hyperplasia, Cystic                  | 2                    4                                      3            |             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                +        +|             
      Angiectasis                          |                                                                4         |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  M  +  M  +  +  M  +  M  +  M  M  +  +  M  +  M  +  +     +|             
      Hyperplasia                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|             
                                           | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                          4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          | 3                                                                        |             
      Hyperplasia                          |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  M  M  M  +  +  +  M  +  +  +  +  M  M  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     | 2        4  2     2                          2  2  2           2         |             
      Hyperplasia, Lymphoid                | 2                    2                                      2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  +  +  M  +  +     +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Fibrous Osteodystrophy               |    1              1                    1  1  3     1     1     2  1      |             
      Fracture                             |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Necrosis                             |             1                                                            |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |       1                       1              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |    1                          1  2                 1     1              1|             
      Inflammation, Suppurative            |    1                                                                    1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Infiltration Cellular, Histiocyte    | 3           2                          2                                 |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Suppurative            |    1  1           1           1     1              1  2  1               |             
      Glands, Hyperplasia                  | 1  1  1  1        1  1  1        2     1  1  1  1  1     1  1  1         |             
      Glands, Metaplasia, Squamous         |                                                                          |             
      Lateral Wall, Metaplasia, Squamous   |          1  1  1                 1           1  1              1  4      |             
      Olfactory Epithelium, Atrophy        | 2  1  1  1        1  1  1        1     1  1  1  1  1  1  1     1  2      |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|             
                                           | 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Hyaline                         |          1        1                       1  1  1                 1      |             
      Olfactory Epithelium, Metaplasia     | 2  1  1  1           1  1        1     1  1  1  1  1     1     1  2      |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  1  1  2     1  1  2  2  1     1  1  1  2  1  1  2  2  2  2  1  2     2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |          1     1              1                                1  4      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cataract                             |                                                                          |             
      Inflammation, Acute                  |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
      Cornea, Degeneration                 | 1                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Metaplasia, Osseous                  |                         1                                   1            |             
      Nephropathy                          | 2  1  1  1     2  1  1  1     1        1  1  2     1  1  1  2  1  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  I  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  A  +  +  +  +|  45        |
      Inflammation, Suppurative            |                   1                                            1         |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Peyer's Patch, Hyperplasia           |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |                                                    4                     |      1  4.0|
      Eosinophilic Focus                   |    X        X        X  X           X           X     X        X  X  X   |     19     |
      Inflammation, Chronic                |                            2     2                                       |      4  2.3|
      Inflammation, Focal, Granulomatous   |                                                 1                        |      2  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Bile                   |                            2                                             |      1  2.0|
      Bile Duct, Cyst                      |                         1                                                |      1  1.0|
      Centrilobular, Necrosis              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                             +           +                              |   6        |
      Fat, Necrosis                        | 2                             2           2                              |      6  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Atrophy                              |                   1                             4                        |      3  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Infiltration Cellular, Mast Cell     |                                           3                              |      1  3.0|
      Inflammation, Suppurative            |       2                                                                  |      2  1.5|
      Ulcer                                |                                           2        1                     |      3  1.3|
      Epithelium, Hyperplasia              |       4                    1           1  4        4           3         |      8  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Inflammation, Suppurative            |       2                 1                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1  1  1  1  1     1        1  1  1  1  1  1  1  1  1  1  1     1  1  1  1|     40  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                     1                                    |      1  1.0|
      Hyperplasia                          |                                                                          |      2  1.0|
      Hypertrophy                          |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  I  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Pars Distalis, Angiectasis           |       3                                                                  |      1  3.0|
      Pars Distalis, Hyperplasia           |    2                 2  2  3  2              1           1           2   |     17  1.5|
      Pars Intermedia, Hyperplasia         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 1  1     1  1     1           1     2  1  1     1     1  1               |     21  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                               2                                          |      2  3.0|
      Atrophy                              |                                                                          |      3  3.3|
      Cyst                                 |       1  2        4  1        2              2  4        2     4  1      |     14  2.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                  4                                       |      1  4.0|
      Inflammation, Chronic                |                                           2                              |      1  2.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Corpus Luteum, Hyperplasia           |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                  4                                       |      1  4.0|
      Hydrometra                           |          2              3  4                                             |      5  3.0|
      Hyperplasia, Cystic                  |                                                                          |      3  3.0|
      Inflammation, Suppurative            |                                              2                           |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |    3                             4                                       |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +     +                                       |   4        |
      Angiectasis                          |                            3     3                                       |      3  3.3|
      Renal, Hyperplasia                   |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  M  M  M  M  +  +  M  M  M  +  +  +  M  +  M  +  +  M  +  +|  27        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M|  40        |
      Hyperplasia                          |                                  3                                       |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia                          |                                           4                              |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +|  34        |
      Hyperplasia                          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |             2        2           2                                       |     11  2.2|
      Hyperplasia, Lymphoid                | 2                                2  2     4                       2      |      8  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  M  +  +  +  +  +  +|  40        |
      Angiectasis                          |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                      2                                                  2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |             2           2  1  2              2  1     2  2           1  1|     19  1.5|
      Fracture                             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                2         |      2  1.5|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |       1                                                                  |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3|            |
                                           | 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                      1                          1                 1      |      9  1.1|
      Inflammation, Suppurative            |                      1                                                   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                         2                                   3            |      5  2.4|
      Mediastinum, Inflammation, Chronic   |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Inflammation, Suppurative            |                      1     1           1        1                        |     12  1.1|
      Glands, Hyperplasia                  |    1  1  1  1     1     1  1  1  1     1  1  1  1     1  2           1  1|     33  1.1|
      Glands, Metaplasia, Squamous         |                         1                                                |      1  1.0|
      Lateral Wall, Metaplasia, Squamous   |                1                 2              1              2  1     1|     14  1.4|
      Olfactory Epithelium, Atrophy        |    1  2  1  1     2     1  1  1        1  1  1  1  1  1  2     3     1  2|     35  1.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |             2              1                    1     1        4  1  2  2|     14  1.4|
      Olfactory Epithelium, Metaplasia     |    1  2  1  1     2     1  1  1        1  1  1  1     1  2           1  2|     31  1.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  2  2     1  1  1  1  2  1  1  1  2  1  1  1  2     1  1     2  2  2  2|     44  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                  4              1              2  1      |      9  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |                                                             2            |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                      4                                                   |      1  4.0|
      Cornea, Degeneration                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +     +  +                                      +   |   5        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Metaplasia, Osseous                  |                                                          1               |      3  1.0|
      Nephropathy                          | 1  1  1  1  1     1  1  1     1     1        1        1  1     2  1  1  1|     35  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|             
                                           | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic                |                                     4                                    |             
      Necrosis                             |                                     3                                    |             
      Epithelium, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia           |                      4                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |    X           X              X           X     X  X  X  X           X   |             
      Hematopoietic Cell Proliferation     |                                        1                          2      |             
      Inflammation, Chronic                |                                     2                                    |             
      Karyomegaly                          |                                     2                                    |             
      Necrosis                             |                                     2                                    |             
      Regeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +     +  +     +  +     +                              |             
      Fat, Hemorrhage                      |                                           1                              |             
      Fat, Necrosis                        |                   3        2     2  3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                         1                       2                        |             
      Hypertrophy                          |    1                          1                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |    1                                                                     |             
      Epithelium, Hyperplasia              |    2                             2                                2  1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                  1              1                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|             
                                           | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               3                          1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  I  +  +  M  +  M  M  +  +  +  M  M  M  +  +  +  +  M  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                                 4                        |             
      Pars Distalis, Hyperplasia           |                                  2                       1  2  1     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Follicular Cell, Hyperplasia         |       2  1           2                    1        1  1     1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  M  +  I  I  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  M  M  A|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 | 2                 2                       4     4  1  4  2        2  2   |             
      Inflammation, Suppurative            |                                                                   4      |             
      Interstitial Cell, Hyperplasia       | 2                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Angiectasis                          |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                   4                                      4           4   |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                                                       3                  |             
      Thrombosis                           |                                                       4                  |             
      Endometrium, Hyperplasia             |                                                                4         |             
      Myometrium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +              +  +   |             
      Angiectasis                          |                                                                      4   |             
      Renal, Hyperplasia                   |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  M  +  M  +  +  M  M  M  +  +  M  M  +  +  +  M  +  M  +  +  +  A|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  A|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|             
                                           | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                   2  4   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hematopoietic Cell Proliferation     |             2  2              2     3  2                          3      |             
      Hyperplasia, Lymphoid                |                   2                                         2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Angiectasis     |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    1  1     1     1                       2  2     1  1                  |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Necrosis                             |                                                 1                        |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
      Degeneration                         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
      Degeneration                         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1                       1            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|             
                                           | 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |       2  1              1  1     2        2  1  2  1  2  2  1  2         |             
      Glands, Hyperplasia                  | 2  3  3  4  3  3  2  4     2  2  4  3  2  3  4  4  3  3  4  2  4  3  3   |             
      Glands, Metaplasia, Squamous         |             1  1  1  1     1     2  1  1  1  1  2     1        1  1  1   |             
      Lateral Wall, Metaplasia, Squamous   |                1     1           1              2        1     2  1      |             
      Lateral Wall, Necrosis               |                                                                          |             
      Olfactory Epithelium, Atrophy        | 2  3  3  4  3  3  2  4  2  3  3  4  4  2  3  4  4  3  3  4  2  4  3  3   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    2  1     2  2     2        2  2  1           3  1  2     1  4  1      |             
      Olfactory Epithelium, Metaplasia     | 2  3  3  4  3  3  2  4  2  3  3  4  4  2  3  4  4  3  3  4  2  4  3  3   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 2  1  2  2  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  2  2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             3  1     2           2  1     2     2  1           2  1      |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
      Respiratory Epithelium, Regeneration |                         1           1  1                             1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                                                          |             
      Cornea, Degeneration                 | 2                                      2                                 |             
      Cornea, Hyperplasia                  | 1     2                                                                  |             
      Cornea, Inflammation, Chronic Active |       2                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                             +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Metaplasia, Osseous                  |    2                                      1                              |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1        2  1  1  1     1  2  1  3  1  1  1  1  1  1  1  2  1  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Squamous                 |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |                                                                         2|      1  2.0|
      Eosinophilic Focus                   | X  X  X        X                 X  X  X  X  X                 X     X   |     20     |
      Hematopoietic Cell Proliferation     |                      1     1                             2               |      5  1.4|
      Inflammation, Chronic                |          2           2                                   1               |      4  1.8|
      Karyomegaly                          |                                                                          |      1  2.0|
      Necrosis                             |                                                    1     2     1         |      4  1.5|
      Regeneration                         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                            +        +        +  +   |  11        |
      Fat, Hemorrhage                      |                                                                          |      1  1.0|
      Fat, Necrosis                        |    4                                            2                 4  4   |      8  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               2                 1                    3   |      5  1.8|
      Hypertrophy                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                          1        2      |      6  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                           +              +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  2  1   |     46  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hypertrophy                          |                1                                                     3   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                 1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  +  M  +  +  +  +  M  +  M  +  M  +  +  +  +  +  M  M  M  +  M  +  M  +|  29        |
      Hyperplasia                          |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 3  2     2  1           2     2     1  1     1                       1   |     15  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |    1           1  2           3     1  1  2                    1     1   |     17  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  M  +  M  +  +  I  M  +  M  +  M  +  +  +  +  M|  31        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                           2                              |      1  2.0|
      Atrophy                              |                                                          2               |      1  2.0|
      Cyst                                 | 2  1     1     1  2     2  4  1                                   2      |     18  2.2|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                             2     4  2   |      4  2.5|
      Hemorrhage                           |                                                             4            |      1  4.0|
      Hydrometra                           |                4                                                         |      4  4.0|
      Hyperplasia, Cystic                  | 3                                                                 4      |      2  3.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                                                                          |      1  4.0|
      Myometrium, Hyperplasia              |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                   +  +   |   5        |
      Angiectasis                          |                                                                      4   |      2  4.0|
      Renal, Hyperplasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  M  M  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  M|  30        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M|  43        |
      Infiltration Cellular, Mast Cell     |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  M  +  M  +  +|  40        |
      Hyperplasia                          |                      3                                                   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                      2     2           2                 2  2           2|     12  2.2|
      Hyperplasia, Lymphoid                |                                     2                          2         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
      Subcutaneous Tissue, Angiectasis     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |          2     1              1     2     1                    1  1      |     15  1.3|
      Hyperostosis                         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Necrosis                             |                                                                          |      1  1.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Mononuclear Cell                |                                  2                          2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                               +                                          |   2        |
      Degeneration                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                               1                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                          3               |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                          2               |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      1  2.0|
      Mediastinum, Inflammation, Chronic   |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    2  1           1  2  1        1  1  2  2           1           3  1   |     25  1.5|
      Glands, Hyperplasia                  | 2  3  3  3  2  2  2     3  3  1  4  3  4  2  1     3  2  2  3  1  2  2  4|     46  2.8|
      Glands, Metaplasia, Squamous         |    1  1  1  1     1  2  1  1  1  1     1  1     1  1  1  1  1        1  1|     34  1.1|
      Lateral Wall, Metaplasia, Squamous   |       1     1        3     1              1     2  3  1  1               |     16  1.4|
      Lateral Wall, Necrosis               |       1                                      3        1           2      |      4  1.8|
      Olfactory Epithelium, Atrophy        | 2  3  3  3  2  2  2  3  3  3  2  4  3  4  2  3  3  3  2  3  3  2  3  3  4|     49  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2                    2  1     2     1     1  2  2  2  1  2     1     3|     28  1.8|
      Olfactory Epithelium, Metaplasia     | 2  3  3  3  2  2  2  3  3  3  2  4  3  4  2  3  3  3  2  3  3  2  3  3  4|     49  3.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  2  1  1  1  1  1  2  1  1  1  1  1  1  1  2  2  1  2  1  1  2  1  1  2|     49  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    1  2  1  1        3     2     1     1        2  3              1      |     21  1.7|
      Respiratory Epithelium, Necrosis     |                                              3                    2      |      2  2.5|
      Respiratory Epithelium, Regeneration | 1                 1     1           1                    1               |      9  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Squamous                 |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                               1                                         4|      2  2.5|
      Cornea, Degeneration                 | 1        1                                                               |      4  1.5|
      Cornea, Hyperplasia                  |                               1                             1            |      4  1.3|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0|            |
                                           | 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +           +        +                                +|   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Mineralization                       |                               2                                          |      1  2.0|
      Nephropathy                          | 1        1  1  1  1  1  1  2  1  1  1        1  1        1  1  1  3  1  1|     40  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                                                  |             
      Clear Cell Focus                     |                                                 X                        |             
      Degeneration, Fatty                  |                                                                          |             
      Eosinophilic Focus                   |             X                 X        X        X  X     X     X         |             
      Hematopoietic Cell Proliferation     |    1                          2                       3                  |             
      Infiltration Cellular, Mixed Cell    |                4                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +  +        +                  |             
      Angiectasis                          |                                              4                           |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                    1                 4        1            |             
      Hypertrophy                          |             2                                                            |             
      Duct, Cyst                           |                                                    4                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                 2                        |             
      Epithelium, Hyperplasia              |                                                 4                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  2  1  1  1  1  1     1  1     1  1  1  1  1  1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          |                                                 1              1         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1     1                             1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  M  +  M  I  +  +  M  +  +  +  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Pars Distalis, Angiectasis           |                                                                         4|             
      Pars Distalis, Hyperplasia           |       4        2     3                    1        1     2        2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2              3  1     2     2     1     1     2     1  3  2     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 2                        |             
      Cyst                                 |    1           2     2  1        2        1  1                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Endometrium, Hyperplasia             |                               3                                          |             
      Endometrium, Metaplasia              |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +|             
      Hyperplasia                          |                2                                2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  M  M  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2        2  3              2  3     2     2        2     2            |             
      Hyperplasia, Lymphoid                |                            2                    2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | 1     1     1     3     2  2     3  2           2        1  1  1  1      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                      2                                                   |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                | 2                    1                                                  2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                      1      |             
      Inflammation, Suppurative            |                            1                                             |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                 3                        |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                 2                        |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3  2  3  2  2        1  2  2        2  1  2  1  2  2  2     2  3     2  2|             
      Glands, Hyperplasia                  | 4  3  4  2  3  3  3  4  2  3  1  2  3  1  3  3  4  3     3  4  4  3  4  2|             
      Glands, Metaplasia, Squamous         | 1  2  2  1  2     1  1  2  1  2  2  2  2  1  1  2  2  1     2  1  1  2  1|             
      Lateral Wall, Metaplasia, Squamous   | 2  1  3  3        1  1  2  1  2  1  2  3     1  2  3  2  3  1        2  1|             
      Lateral Wall, Necrosis               |                                                                          |             
      Olfactory Epithelium, Atrophy        | 4  4  4  3  3  3  4  4  2  4  2  2  4  3  4  4  4  4  4  3  4  4  3  4  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 4  2  2     3     2  2  2  1  2  2  2  1  3  2  2  1  3     3  3  2  3  2|             
      Olfactory Epithelium, Metaplasia     | 4  4  4  3     3  4  4  2  4  2  2  4  3  3  4  4  4  4  3  4  4  3  4  3|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1  1  2  2  1  1  1  1  1     1  2  1  1  1  1  3  2  1  2  1  2  1  1  1|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Polypoid                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|             
                                           | 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    32.0 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2  1  4  2  1        1  2  1  2  1  3  3  1  1  2  3  2  3  1        2   |             
      Respiratory Epithelium, Necrosis     |                                                                          |             
      Respiratory Epithelium, Regeneration |                1     1                                            1     1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                         2|             
      Cornea, Degeneration                 |    4  1     2  2  2  2  2  1  1  2  1     1        2  2  3               |             
      Cornea, Hyperplasia                  |                                  1  1           1        1               |             
      Cornea, Inflammation, Chronic Active |    2                                            1                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +     +                          +  +                       +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                            1                             1               |             
      Nephropathy                          | 1  1  1  1        1        1  1  1  1  1  1  1  1  1  1  1  1  1  1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  M  M  +  +  +  +  +  I  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |       X                                                                  |      2     |
      Clear Cell Focus                     |                                                 X                        |      2     |
      Degeneration, Fatty                  |                   1                                                      |      1  1.0|
      Eosinophilic Focus                   |                                                                         X|      8     |
      Hematopoietic Cell Proliferation     |             3                       2                                    |      5  2.2|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  4.0|
      Inflammation, Chronic                |             2                                                            |      1  2.0|
      Necrosis                             |    1        2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                       +     +  +  +        +                     |  10        |
      Angiectasis                          |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                     3                                    |      1  3.0|
      Fat, Hemorrhage                      |                                     3                                    |      1  3.0|
      Fat, Necrosis                        |       2                       2     2  2           2                     |      7  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |
      Pharyngeal, Hyperplasia              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 1  4                          1                                1        1|      9  1.7|
      Hypertrophy                          |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                     2                                2   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1     1  1  1  1  1        1     1  1  1  1  1     1  1  1  1  1  1  1|     42  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Hypertrophy                          |                                                                   1      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                   1                                                      |      4  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  I  I  M  M  +  +  +  M  M  M  M  M  +  M  +  M  +  +  M|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |             2  3  2  3           1  1              2           1  3     1|     17  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 1           1  1  1  4  2     1  1  1        1     2  1  1  2  1     2  1|     30  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               2                                          |      2  2.0|
      Cyst                                 | 2        3     1              3           4  2     1     1               |     15  1.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  49        |
      Angiectasis                          |                         2           4                                    |      2  3.0|
      Hydrometra                           |          2                 2     3                                       |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                                                                          |      1  3.0|
      Endometrium, Metaplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                     +     +                             +|   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  +  M  M  +  M  M  +  +  M  +  +  +  +  M  +  +  +  +|  37        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +|  40        |
      Hyperplasia                          |                                                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                   2     1                                                |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                     3                                    |      1  3.0|
      Hyperplasia                          |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Hyperplasia                          |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          2  3        2  2           4                       2        2   |     17  2.3|
      Hyperplasia, Lymphoid                |    2                                                              2     4|      5  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +  +  A  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   1                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                           1                              |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |    2     2        1  2           2                 1           1  1  2   |     22  1.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Gliosis                              |                                                                          |      1  2.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |                                                                      1   |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       1              1                 1                                 |      5  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                            1                                         2   |      3  2.0|
      Inflammation, Chronic, Focal         |                      1                                                   |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    32.0 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 2  2     2  2  2  2  2  3  1  3     2  2  2  3  3  1  3  2  1  1  1  3  2|     42  2.0|
      Glands, Hyperplasia                  | 3  3  4  3  4  4  3  4  3     4  4  3  3  3  4  3  3  4     3  1  2  3  4|     47  3.1|
      Glands, Metaplasia, Squamous         | 1  2  1  1  1  2  2  1  1     2  2  3  3  2  1  1  2  1     1  1  1  1  2|     46  1.5|
      Lateral Wall, Metaplasia, Squamous   |    2  2     1     2  2  2        2  3  3  2  2  2  1           1     1  2|     36  1.9|
      Lateral Wall, Necrosis               |                                                             2            |      1  2.0|
      Olfactory Epithelium, Atrophy        | 4  4  3  4  4  4  3  4  4  3  4  4  3  4  4  4  4  4  4  4  4  3  3  4  4|     50  3.6|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  3  2  2  3  2  2  1  1  2  2  4  3  2  2  3  2  2     3     1  2  2  2|     46  2.2|
      Olfactory Epithelium, Metaplasia     | 4  4  3  4  4  4  3  4  4  3  4  4  3  4  4  4  4  3  4  4  4  3  3  4  4|     49  3.6|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  2  2     1  2  2  1  2  1  1  1  1  1  1  2  1  2  2  2  1  1  2  2  1|     48  1.4|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Polypoid                        |                                                                         1|      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    2  2  1  1  2  2  2  2        3  2  3  3  3  1  1     2  2  1        2|     39  1.9|
      Respiratory Epithelium, Necrosis     |                         2                                1        1      |      3  1.3|
      Respiratory Epithelium, Regeneration | 1        1                    2        1        1  1  2  1        1      |     13  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                                                                          |      1  2.0|
      Cornea, Degeneration                 |    2        1     3  3              1        3  3  2  2  3           2   |     26  2.0|
      Cornea, Hyperplasia                  |                                                    1     1           1   |      7  1.0|
      Cornea, Inflammation, Chronic Active |                                                          2               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Osseous                  |                               1                                      1   |      4  1.0|
      Nephropathy                          | 1  1     1  1  1  1  1  1     1     1  1  1  1  1  1  1     1     1  1  1|     39  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Anus, Inflammation, Chronic Active   |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                          2              2|             
      Eosinophilic Focus                   |    X  X  X     X     X  X     X                 X  X              X      |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |                                                          4               |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                       +  +                                 |             
      Fat, Necrosis                        |       2     2                       2  2                                 |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1        1                                1     1              1     1|             
      Hypertrophy                          |                               1                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |    1                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1|             
      Atrium, Thrombosis                   |                                              3                           |             
      Ventricle, Thrombosis                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    1  2  1  1  1  1  1  1  1  1  1              1  2  1        1  1  3  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1     1           2  1     1     1  2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  M  M  +  +  M  +  M  +  M  +  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                1     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |             1              1                                2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              2                       1   |             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               1                                         2|             
      Inflammation                         |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                       2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  I  +  +  +  M  +  +  +  +  M  M  M  M  +  +  M  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                                   2        2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  M  +  +  +  +  M  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              4                    2      |             
      Mineralization                       |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Inflammation, Chronic Active| 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                   X      |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Mononuclear Cell                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2           3  1     1                  |             
      Olfactory Epithelium, Atrophy        |                                  1                                       |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                           2                              |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1                                            1                    1   |             
      Respiratory Epithelium, Necrosis     |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                           1     1                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                             2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Cornea, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     1                                    |             
      Hydronephrosis                       |                                              2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Osseous                  |                                                                         2|             
      Nephropathy                          | 1  1  1  2  1  1  1  2  2  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1  1|             
      Renal Tubule, Hyperplasia            |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3                                                                        |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Anus, Inflammation, Chronic Active   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                                        1                 1              2|      5  1.6|
      Eosinophilic Focus                   | X              X                                            X            |     13     |
      Hematopoietic Cell Proliferation     |                                     1                                    |      2  1.5|
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Necrosis                             |                                     2                                3   |      2  2.5|
      Bile Duct, Cyst                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                    +  +         |   7        |
      Fat, Necrosis                        |                                        3                    2  4         |      7  2.4|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                   1      |      7  1.0|
      Hypertrophy                          |                                                                          |      1  1.0|
      Duct, Cyst                           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                 1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                1         |      1  1.0|
      Necrosis                             |                   1                                                  1   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                +         |   2        |
      Developmental Malformation           |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  1     1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|     46  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
      Ventricle, Thrombosis                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                              1                           |      1  1.0|
      Hypertrophy                          | 1  2  1  1  1  2           1     1  1  2              1  1  1  3  1  3  1|     35  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1                                                           2         |      9  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  M  +  +  M  +  M  +  +  +  M  +  M  M  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Hyperplasia           |          1                                                               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |    1                                      1  1  1                       2|      8  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Spermatocele                         |       2     2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          2                                                               |      3  1.7|
      Inflammation                         |       1                                                                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                4     1   |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     2              2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  M  +  M  M  +  M  M  M  M  M  M  +  +  +  +  M  M  +|  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  M  +  M  +  +  M  +  M  M  M  M  M  +  M  +  +  +  +  M  +|  28        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  I  +  +  M  +|  40        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                         2     2     2              3                     |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  +  +  M  M  M  M  +  +  +  +  +  +  M  +|  35        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                                           2        4                     |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Mononuclear Cell                |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 2                        |      2  1.5|
      Inflammation, Suppurative            |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |             4                       2        4        3                  |      4  3.3|
      Alveolar Epithelium, Hyperplasia     | 1                                      1        1                       2|      5  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1                             1                    1                  |      7  1.4|
      Olfactory Epithelium, Atrophy        |                                                       1        1         |      3  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                1         |      2  1.5|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          1                                1                              |      5  1.0|
      Respiratory Epithelium, Necrosis     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cataract                             |                                                                2         |      2  2.0|
      Inflammation, Chronic Active         |                      1     2                                             |      2  1.5|
      Cornea, Hyperplasia                  |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +  +  +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Hydronephrosis                       |    2                                                                     |      2  2.0|
      Inflammation, Chronic Active         |                                           3        2                     |      2  2.5|
      Metaplasia, Osseous                  |                                                          1              1|      3  1.3|
      Nephropathy                          | 1  1  1  1  1  1     1  1  1  2  1  1  1  1  1  3  1  1  1  1  1  1  2  2|     49  1.2|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                           3        4                     |      3  3.3|
      Transitional Epithelium, Hyperplasia |                                                    2                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|             
                                           | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  A  +  +  +  +|             
      Degeneration, Hyaline                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Peyer's Patch, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                                            |             
      Clear Cell Focus                     |                               X           X                              |             
      Degeneration, Cystic                 |                                                    2                     |             
      Degeneration, Fatty                  |                                  2                                       |             
      Eosinophilic Focus                   |                   X     X     X           X  X        X  X        X  X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                                    3  1                  |             
      Vacuolization Cytoplasmic            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                             +                        |             
      Fat, Necrosis                        |                   2                             2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                                                   1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                                                       4                  |             
      Duct, Hyperplasia                    |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Diverticulum                         |                                                          X               |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |       3                                1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Inflammation                         |                            2                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  2  1     1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
      Hypertrophy                          | 1  1  1  2  2  1  1     1     2           1  1  1  1  2  1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|             
                                           | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 |                                                                         4|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |    1              1                                      1              1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  M  +  +  +  M  M  +  M  +  I  M  M  +  M  +  +  A  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Pars Distalis, Hyperplasia           |             1                    1                                1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                         1                    1           2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation                         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |          3                                2                             2|             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                       3                       2                     |             
      Mineralization                       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  M  +  M  M  M  A  +  M  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  A  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  +  M  +  +  M  M  +  +  +  +  +  +  A  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2     2        2  2        2     2  2     2        2|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  +  M  +  +  +  M  M  +  M  M  M  M  A  +  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|             
                                           | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                                     4     2                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                 4                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Granulomatous            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                                1     3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            |    2  1                                                                 1|             
      Glands, Hyperplasia                  |          1                    1           1     1                        |             
      Glands, Metaplasia, Squamous         |                1     1              1        1                           |             
      Lateral Wall, Metaplasia, Squamous   |                      1  1           1                          1  1      |             
      Olfactory Epithelium, Atrophy        |    3  1  1        1  1                    1  1  1                        |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    2                                                           2         |             
      Olfactory Epithelium, Metaplasia     |    1  1  1        1                       1     1                        |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    2        1  1     1                 1  1     1        1           1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Regeneration |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|             
                                           | 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             |                                                    1                     |             
      Cornea, Inflammation, Chronic Active |                                                                3         |             
      Retina, Atrophy                      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +     +              +  +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                     1                                    |             
      Metaplasia, Osseous                  |          1     1                                                         |             
      Nephropathy                          | 1  2  1  2  1  1  1  1  2  3  2  1     1  2  2  2  2  2  3     1  1  1  2|             
      Renal Tubule, Hyperplasia            |                   1           1                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  42        |
      Degeneration, Hyaline                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Peyer's Patch, Hyperplasia           |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |          X     X  X                                X                     |      5     |
      Clear Cell Focus                     |                                                       X                  |      3     |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Eosinophilic Focus                   | X     X           X        X           X                       X  X  X  X|     18     |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Necrosis                             |             2                                      2                     |      4  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                            +               |   4        |
      Fat, Necrosis                        |             4                                            2               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                               1  1                                       |      3  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                                          |      1     |
      Hyperkeratosis                       |             2                                                            |      1  2.0|
      Inflammation, Suppurative            |                                                 2                        |      1  2.0|
      Epithelium, Hyperplasia              |                      1              4           3                        |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1|     47  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |    1  3  1     1  1  1  1  1  2  1  1     1  1  1     2  1     2  1     2|     37  1.3|
      Capsule, Hyperplasia                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    1                       1                                         2   |      7  1.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |          1                                                               |      4  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |                                     2     2  1           1        1     1|      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                             +            |   2        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      3  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                                      +   |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  +  M  +  M  M  M  M  M  +  M  M  M  M  +  +  M  +  +  +  M|  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  M  +  +  M  M  M  +  +  M  +  M  +  M  M  +  M  M  M|  33        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  39        |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |             2                 2                 2                        |     12  2.0|
      Hyperplasia, Lymphoid                |                                                                      4   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  +  +  +  M  +  +  M  M  +  +  M  +  M  +  +  +  +  M  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                                                                          |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                             3            |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Granulomatous            |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                      1                                                   |      1  1.0|
      Hyperostosis                         |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     1                                    |      1  1.0|
      Infiltration Cellular, Histiocyte    |          4                    4                 2                        |      4  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    2     1                 1  1        1     1     1           1         |     11  1.2|
      Glands, Hyperplasia                  |    1           1                       1     1     1  1                  |     10  1.0|
      Glands, Metaplasia, Squamous         |                                              1                 1         |      6  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    2.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lateral Wall, Metaplasia, Squamous   |    1                    1  1                                1            |      9  1.0|
      Olfactory Epithelium, Atrophy        |    1     2     1                       1     1     1  1                  |     15  1.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                   1                                                      |      3  1.7|
      Olfactory Epithelium, Metaplasia     |    1     2                             1     1     1  1                  |     12  1.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |    1  1  1     1                    1              1  1  2              1|     18  1.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    1                    1                                                |      2  1.0|
      Respiratory Epithelium, Regeneration |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Cataract                             |                                                                          |      1  1.0|
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | 2     3                                                              1   |      3  2.0|
      Hydronephrosis                       |                                                             1            |      2  1.0|
      Metaplasia, Osseous                  |    1                                                                 2   |      4  1.3|
      Nephropathy                          | 1  1  3  1  1  1  1  1  1  1  1  1  1  1  2  1  2  1  1  1  1  2  1  1  1|     48  1.4|
      Renal Tubule, Hyperplasia            |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
      Transitional Epithelium, Hyperplasia |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|             
                                           | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  M  +|             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                 X           X            |             
      Eosinophilic Focus                   |             X              X              X                 X     X     X|             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                  1     2                                 |             
      Bile Duct, Cyst                      |                                                             3            |             
      Centrilobular, Degeneration          |                                                             2            |             
      Centrilobular, Necrosis              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +     +           +                              |             
      Fat, Necrosis                        |                         2     2           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |             1                 1                                          |             
      Hypertrophy                          |             1                                                            |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                        2                                 |             
      Epithelium, Hyperplasia              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Inflammation                         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1  1  1  1  2  1  1  1  1  1  1  1     1  2  2     1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2     1                 1     1|             
      Hypertrophy                          |    1        3           1  1     1  2     1     1           1     2  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|             
                                           | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       1              1           2        1                 2        1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  +  +  M  M  +  +  +  +  M  +  M  +  +  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1        2                                               2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  4                                       |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            3                                             |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Suppurative            |                         1                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation                         |                                           1                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                     1                 4        1         |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  M  M  M  +  M  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  M|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  M  +  M  M  +  M  +  +  +  M  M  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                   2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2        2           2                       3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  M  +  +  +  +  M  M  +  M  +  +  M  +  M  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|             
                                           | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Prepuce, Inflammation, Chronic Active|                            4                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                       3                  |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1           1   |             
      Inflammation, Suppurative            |                                                          1               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                    4  3        2         |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1     1  2        1  2  1     1  1  1  2  1        1  1     1|             
      Glands, Hyperplasia                  | 1  1  1     1  2  2  2  1  2  1  2  1  1  2  2  2  1  2  2  3  2  3  2  2|             
      Glands, Metaplasia, Squamous         |    1  1  1  1  1           1  1  1  1     1  1  1     1  2  1            |             
      Lateral Wall, Metaplasia, Squamous   |          4                                      1     1  2           1   |             
      Lateral Wall, Necrosis               |                                                 2  1                     |             
      Olfactory Epithelium, Atrophy        | 2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  1  2  2  3  2  3  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    1           1  2  1           1                          2  1  1     2|             
      Olfactory Epithelium, Metaplasia     | 2  2  1  2  2  3  2  2  2  2  2  2  2  2  2  2  2  1  2  2  3  2  3  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |    1  1  1  2  1  2  1     2  1  1  1  1  1  1  1  1  2  1  2  1  1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                         1                          1  1                  |             
      Respiratory Epithelium, Regeneration |                            1  1           1     1              1  1     1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|             
                             DAY ON TEST   | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|             
                                           | 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    8.0 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cataract                             | 1                 1                                                      |             
      Cornea, Dysplasia                    | 1                                                                        |             
      Cornea, Hyperplasia                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |    1  1  2  2        2     1  1  1  2  1  2     2  2  2  1  1  1  2     1|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Hypertrophy            |    1                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3                                                |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8|            |
                                           | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  42        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |                                     X                                    |      3     |
      Eosinophilic Focus                   |          X     X                          X  X        X           X      |     12     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                          3               |      1  3.0|
      Necrosis                             |             2                          2           4              1      |      6  2.0|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Centrilobular, Degeneration          |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                          +           +                              |   7        |
      Fat, Necrosis                        |    3                          2           2                              |      6  2.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                    1                 1   |      4  1.0|
      Hypertrophy                          |                                                                1         |      2  1.0|
      Duct, Cyst                           |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                               2                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                       2                  |      2  1.5|
      Necrosis                             |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  1  1  2  1  1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1|     43  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8|            |
                                           | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                                                                     |      5  1.4|
      Hypertrophy                          | 2     1  1     1  1  1  1     1  1     1  1  1  2     1  1  1  1  2  1   |     31  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                1                          1        1  1                  |     10  1.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  M  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  M  +  M  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |                1                                                         |      1  1.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |       1                                                  1           1   |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                   1      |      2  2.5|
      Mineralization                       |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | 4                                                                        |      2  3.5|
      Inflammation                         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                              4                           |      1  4.0|
      Atrophy                              |                2                                                        1|      5  1.8|
      Degeneration                         |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  M  M  +  M  M  M  M  +  +  +  +  +  M  M  M  +  M  M  M|  27        |
      Hyperplasia                          |                                           4                              |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  +  M  +  M  M  M  M  M  M  +  +  +  +  M  M  +  M  M  M  M  +  +|  23        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8|            |
                                           | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     | 2  2  2     2                          2                 2              2|     11  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  A  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M|  36        |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst Epithelial Inclusion            |                                                          X               |      1     |
      Prepuce, Inflammation, Chronic Active|                                        4                                4|      3  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                   1      |      2  2.0|
      Hyperostosis                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                     2     4                              |      5  3.0|
      Inflammation, Chronic, Focal         |                                                                   1      |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |          1     1  1  1  1     2  1  2  1  2                 2     2  2   |     27  1.3|
      Glands, Hyperplasia                  | 2  2  2  1  1  3  3  2  3     1  1  3  1  1  2  2  2  1  1  2  1  2  2  2|     48  1.8|
      Glands, Metaplasia, Squamous         | 1  1  1  1  1  1  2  1  1     1  1  1     2  2        1  1  1  1  1  1   |     35  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05201-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 03/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 21:32:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5|            |
                             DAY ON TEST   | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8|            |
                                           | 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    8.0 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lateral Wall, Metaplasia, Squamous   |    1           1  3                       2                 1            |     10  1.7|
      Lateral Wall, Necrosis               |                               1                                          |      3  1.3|
      Olfactory Epithelium, Atrophy        | 2  2  2  2  2  3  3  3  3     2  2  4  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1  1           1  2  2  1           2              1  1     1        1  1|     21  1.3|
      Olfactory Epithelium, Metaplasia     | 2  2  2  2  2  3  3  3  3     2  2  4  2  2  2  2  2  2  2  2  2  2  2  2|     49  2.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1  1  1     1  1  1  1     2  2  1  2     2  2  2     1  2  1  1  1  2|     42  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                           2  1     1  1  1  1  1         |     10  1.1|
      Respiratory Epithelium, Regeneration | 1        1  1                 1     1  1                                 |     13  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cataract                             |                                  2                                       |      3  1.3|
      Cornea, Dysplasia                    |                                                                          |      1  1.0|
      Cornea, Hyperplasia                  |                               2                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                            +  +  +                             +         |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                         1|      1  1.0|
      In