TDMS Study 05201-06 Pathology Tables
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
CHRONIC STUDY
Facility: Battelle Northwest
Chemical CAS #: 0098-00-0000
Lock Date: 01/26/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|
| 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + M + + + M + + A + + + M + +|
Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + A + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | |
Inflammation, Focal, Granulomatous | 3 |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 2 4 3 3 2 2 2 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 1 |
Hyperplasia, Lymphoid | |
Hypertrophy | |
Inflammation, Chronic, Focal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + I + + + + + M +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M M + + + + + M M + + M + M + + M|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|
| 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I M + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 4 4 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 1 1 3 2 2 2 2 2 2|
Infiltration Cellular, Mononuclear | |
Cell | |
Corpus Luteum, Hemorrhage | |
Germinal Epithelium, Hyperplasia | |
Interstitial Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hydrometra | 3 |
Hyperplasia, Cystic | 3 4 2 |
Inflammation, Suppurative | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Angiectasis | |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M I + + M + + + + + M + M + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + + + M M + M M + M + M + M + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + M + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + M + + + + + + + M + + + + + +|
Hyperplasia | 4 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + M + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|
| 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Subcutaneous Tissue, Angiectasis | 3 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 1 1 1 2 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 1 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Epiglottis, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 4 3 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
Glands, Metaplasia, Squamous | |
Lateral Wall, Metaplasia, Squamous | |
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 2 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Pleura | + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 4| 3| 9| 3| 3| 3| 0| 3| 3| 6| 3| 3| 3| 1| 8| 3| 3| 3| 3| 3| 3|
| 7| 4| 4| 4| 7| 4| 5| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 5| 9| 5| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Degeneration | 1 1|
Cornea, Fibrosis | 2 |
Cornea, Hyperplasia | 1 1 |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| |
| 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + A + + + + + + + + +| 43 |
Degeneration, Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 | 1 2.0|
Eosinophilic Focus | X X X X X X X X X | 14 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Inflammation, Focal, Granulomatous | | 1 3.0|
Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 15 |
Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 4 4 1 4 | 13 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 1 | 7 1.4|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hypertrophy | 1 | 1 1.0|
Inflammation, Chronic, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1| 36 1.1|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| |
| 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + M + M M + + + + + + + + M + + M + + M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 1 2 1 2 1 1 3 2| 15 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Follicular Cell, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 | 17 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + M + M + + + I + + + +| 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 2| 4 2.0|
Cyst | 2 2 1 1 2 | 14 1.8|
Infiltration Cellular, Mononuclear | | |
Cell | 2 | 1 2.0|
Corpus Luteum, Hemorrhage | 2 | 1 2.0|
Germinal Epithelium, Hyperplasia | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 3 2.3|
Hydrometra | 3 2 3 2 | 5 2.6|
Hyperplasia, Cystic | 2 | 4 2.8|
Inflammation, Suppurative | 4 | 1 4.0|
Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 6 |
Angiectasis | 4 3 3 4| 4 3.5|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M + M M + + + + + M + + M + + + M + + + M +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| |
| 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + + + + M + + + + M + + + + + + +| 36 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + M + + + M + M + + + + M + + M + + + +| 41 |
Hyperplasia | 3 | 4 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 3 | 11 2.2|
Hyperplasia, Lymphoid | 2 2 2 2 2| 8 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + + M + + + + + + M M + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Subcutaneous Tissue, Angiectasis | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 4 1 1 1 2 3 2| 16 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 4 1.3|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Hyperplasia | 1 2 3 | 5 1.6|
Epiglottis, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 3 2.7|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 4| 3| 3| 5| 3| 9| 5| 3| 3| 3| 3| 3| 7| 1| 3| 9| 5| 3| 3| 3| 3| 3| |
| 5| 4| 5| 8| 5| 5| 2| 5| 6| 1| 5| 5| 5| 5| 5| 3| 2| 5| 3| 1| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Glands, Metaplasia, Squamous | 1 | 1 1.0|
Lateral Wall, Metaplasia, Squamous | 1 1 1 | 3 1.0|
Olfactory Epithelium, Atrophy | | 2 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 | 7 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 2 2 2 2 1 1 2| 19 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pleura | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 1 1 | 2 1.0|
Cornea, Degeneration | 1 | 3 1.0|
Cornea, Fibrosis | | 1 2.0|
Cornea, Hyperplasia | | 2 1.0|
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 41 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|
| 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + M + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X X X X X|
Inflammation, Chronic | 3 2 |
Inflammation, Focal, Granulomatous | 1 |
Necrosis | 2 |
Pigmentation, Bile | |
Bile Duct, Cyst | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | 1 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Inflammation, Suppurative | 1 |
Ulcer | 1|
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + A|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|
| 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + M M + + + M + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 1 1 1 1 1 1 2|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + I + M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 4 2 4 |
Cyst | 4 3 4 4 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Thrombosis | 4 |
Corpus Luteum, Hyperplasia | 3 |
Interstitial Cell, Hyperplasia | 2 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydrometra | 4 2|
Hyperplasia, Cystic | 2 4 3 |
Inflammation, Suppurative | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + +|
Angiectasis | 4 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M + M + + M + M + M M + + M + M + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + M M + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|
| 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M + M M M + + + M + + + + M M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + M M + + + M + + + M + + + M + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 3 1 1 2 1 |
Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 1|
Inflammation, Suppurative | 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Histiocyte | 3 2 2 |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 |
Glands, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Glands, Metaplasia, Squamous | |
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 1 1 4 |
Olfactory Epithelium, Atrophy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Olfactory Epithelium, Degeneration, | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| 6| 4| 7| 7| 7| 4| 7| 6| 7| 7| 7| 6| 1| 7|
DAY ON TEST | 3| 3| 3| 0| 2| 2| 3| 3| 3| 6| 3| 8| 9| 3| 3| 3| 5| 3| 8| 3| 3| 3| 4| 2| 3|
| 4| 4| 4| 1| 5| 1| 4| 4| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 1| 5| 5| 5| 9| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyaline | 1 1 1 1 1 1 |
Olfactory Epithelium, Metaplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 2 1 1 2 2 1 1 1 1 2 1 1 2 2 2 2 1 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 1 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Cornea, Degeneration | 1 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 1 |
Nephropathy | 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + I + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| |
| 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + M + + + + A + + + +| 45 |
Inflammation, Suppurative | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + A + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 4 | 1 4.0|
Eosinophilic Focus | X X X X X X X X X X | 19 |
Inflammation, Chronic | 2 2 | 4 2.3|
Inflammation, Focal, Granulomatous | 1 | 2 1.0|
Necrosis | | 1 2.0|
Pigmentation, Bile | 2 | 1 2.0|
Bile Duct, Cyst | 1 | 1 1.0|
Centrilobular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Atrophy | 1 4 | 3 2.0|
Cytoplasmic Alteration | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Infiltration Cellular, Mast Cell | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 2 1.5|
Ulcer | 2 1 | 3 1.3|
Epithelium, Hyperplasia | 4 1 1 4 4 3 | 8 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
Inflammation, Suppurative | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| |
| 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Hyperplasia | | 2 1.0|
Hypertrophy | 1| 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + I + + M + + + M M + + + + M + + M + + + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 2 2 3 2 1 1 2 | 17 1.5|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 | 21 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M M + + + + + + M + + + M + + + + M| 41 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 2 3.0|
Atrophy | | 3 3.3|
Cyst | 1 2 4 1 2 2 4 2 4 1 | 14 2.7|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Thrombosis | | 1 4.0|
Corpus Luteum, Hyperplasia | | 1 3.0|
Interstitial Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Hydrometra | 2 3 4 | 5 3.0|
Hyperplasia, Cystic | | 3 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| |
| 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Thrombosis | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Angiectasis | 3 3 | 3 3.3|
Renal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M M M M + + M M M + + + M + M + + M + +| 27 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + + + + + + + M + + + + + + + + M + M| 40 |
Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + A + + + +| 47 |
Angiectasis | | 1 3.0|
Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + M + M M + + + + + M M + M + + + + +| 34 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hematopoietic Cell Proliferation | 2 2 2 | 11 2.2|
Hyperplasia, Lymphoid | 2 2 2 4 2 | 8 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + I + + + + M M + + + + + +| 40 |
Angiectasis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 2 2 1 2 2 1 2 2 1 1| 19 1.5|
Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 2 | 2 1.5|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 4| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 3| 3| 4| 8| 3| 3| 3| |
| 5| 5| 5| 5| 5| 6| 5| 1| 5| 5| 5| 0| 5| 5| 5| 5| 5| 1| 5| 5| 8| 7| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 | 9 1.1|
Inflammation, Suppurative | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, Histiocyte | 2 3 | 5 2.4|
Mediastinum, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 | 12 1.1|
Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 33 1.1|
Glands, Metaplasia, Squamous | 1 | 1 1.0|
Lateral Wall, Metaplasia, Squamous | 1 2 1 2 1 1| 14 1.4|
Olfactory Epithelium, Atrophy | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 3 1 2| 35 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 1 4 1 2 2| 14 1.4|
Olfactory Epithelium, Metaplasia | 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 2| 31 1.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 2 1 1 1 1 2 1 1 1 2 1 1 1 2 1 1 2 2 2 2| 44 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 4 1 2 1 | 9 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 2 | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 4 | 1 4.0|
Cornea, Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Metaplasia, Osseous | 1 | 3 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 35 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + I + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|
| 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + A|
Angiectasis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Metaplasia, Squamous | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic | 4 |
Necrosis | 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | 1 2 |
Inflammation, Chronic | 2 |
Karyomegaly | 2 |
Necrosis | 2 |
Regeneration | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Hemorrhage | 1 |
Fat, Necrosis | 3 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | 1 2 |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|
| 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + I + + M + M M + + + M M M + + + + M M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Follicular Cell, Hyperplasia | 2 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + I I M + + + + + + + + + + M M + + M + M M A|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis | |
Atrophy | |
Cyst | 2 2 4 4 1 4 2 2 2 |
Inflammation, Suppurative | 4 |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis | 2 |
Hemorrhage | |
Hydrometra | 4 4 4 |
Hyperplasia, Cystic | |
Inflammation, Chronic | 3 |
Thrombosis | 4 |
Endometrium, Hyperplasia | 4 |
Myometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Angiectasis | 4 |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M + M + + M M M + + M M + + + M + M + + + A|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + M + + + + + + + M + + + + A|
Infiltration Cellular, Mast Cell | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|
| 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + A|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M + + + + + + + + M + + + + + + + + + A|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 1 2 2 1 1 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + A|
Necrosis | 1 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Peripheral Nerve | + |
Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 8|
| 4| 2| 4| 4| 3| 7| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 1 1 2 2 1 2 1 2 2 1 2 |
Glands, Hyperplasia | 2 3 3 4 3 3 2 4 2 2 4 3 2 3 4 4 3 3 4 2 4 3 3 |
Glands, Metaplasia, Squamous | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 |
Lateral Wall, Metaplasia, Squamous | 1 1 1 2 1 2 1 |
Lateral Wall, Necrosis | |
Olfactory Epithelium, Atrophy | 2 3 3 4 3 3 2 4 2 3 3 4 4 2 3 4 4 3 3 4 2 4 3 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 2 2 2 2 1 3 1 2 1 4 1 |
Olfactory Epithelium, Metaplasia | 2 3 3 4 3 3 2 4 2 3 3 4 4 2 3 4 4 3 3 4 2 4 3 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 1 2 2 1 2 2 1 2 1 |
Respiratory Epithelium, Necrosis | |
Respiratory Epithelium, Regeneration | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | |
Cornea, Degeneration | 2 2 |
Cornea, Hyperplasia | 1 2 |
Cornea, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Metaplasia, Osseous | 2 1 |
Mineralization | |
Nephropathy | 1 1 2 1 1 1 1 2 1 3 1 1 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| |
| 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Inflammation, Chronic | | 1 4.0|
Necrosis | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2| 1 2.0|
Eosinophilic Focus | X X X X X X X X X X X | 20 |
Hematopoietic Cell Proliferation | 1 1 2 | 5 1.4|
Inflammation, Chronic | 2 2 1 | 4 1.8|
Karyomegaly | | 1 2.0|
Necrosis | 1 2 1 | 4 1.5|
Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Fat, Hemorrhage | | 1 1.0|
Fat, Necrosis | 4 2 4 4 | 8 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 1 3 | 5 1.8|
Hypertrophy | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| |
| 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 46 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy | 1 3 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | I + M + + + + M + M + M + + + + + M M M + M + M +| 29 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 2 2 1 2 2 1 1 1 1 | 15 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 2 3 1 1 2 1 1 | 17 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + M + M + + I M + M + M + + + + M| 31 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Atrophy | 2 | 1 2.0|
Cyst | 2 1 1 1 2 2 4 1 2 | 18 2.2|
Inflammation, Suppurative | | 1 4.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 4 2 | 4 2.5|
Hemorrhage | 4 | 1 4.0|
Hydrometra | 4 | 4 4.0|
Hyperplasia, Cystic | 3 4 | 2 3.5|
Inflammation, Chronic | | 1 3.0|
Thrombosis | | 1 4.0|
Endometrium, Hyperplasia | | 1 4.0|
Myometrium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| |
| 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Angiectasis | 4 | 2 4.0|
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M M + + + + + M M + + M + + M + + + M| 30 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + M + + + M| 43 |
Infiltration Cellular, Mast Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + M + + + + M M + + + M + M + +| 40 |
Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2| 12 2.2|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + M + + + + +| 46 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Subcutaneous Tissue, Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 1 1 2 1 1 1 | 15 1.3|
Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 1 1.0|
Meninges, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| |
| 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mononuclear Cell | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 1 2 1 1 1 2 2 1 3 1 | 25 1.5|
Glands, Hyperplasia | 2 3 3 3 2 2 2 3 3 1 4 3 4 2 1 3 2 2 3 1 2 2 4| 46 2.8|
Glands, Metaplasia, Squamous | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 34 1.1|
Lateral Wall, Metaplasia, Squamous | 1 1 3 1 1 2 3 1 1 | 16 1.4|
Lateral Wall, Necrosis | 1 3 1 2 | 4 1.8|
Olfactory Epithelium, Atrophy | 2 3 3 3 2 2 2 3 3 3 2 4 3 4 2 3 3 3 2 3 3 2 3 3 4| 49 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 1 2 1 1 2 2 2 1 2 1 3| 28 1.8|
Olfactory Epithelium, Metaplasia | 2 3 3 3 2 2 2 3 3 3 2 4 3 4 2 3 3 3 2 3 3 2 3 3 4| 49 3.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 2| 49 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2 1 1 3 2 1 1 2 3 1 | 21 1.7|
Respiratory Epithelium, Necrosis | 3 2 | 2 2.5|
Respiratory Epithelium, Regeneration | 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Squamous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 1 4| 2 2.5|
Cornea, Degeneration | 1 1 | 4 1.5|
Cornea, Hyperplasia | 1 1 | 4 1.3|
Cornea, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 4| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 1| 3| 8| 3| 3| 3| 3| 9| 6| 2| 1| 6| 3| 3| 3| 3| 3| 0| |
| 5| 5| 5| 5| 5| 5| 5| 1| 5| 2| 5| 5| 5| 5| 8| 5| 1| 7| 9| 9| 5| 5| 5| 5| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Osseous | | 2 1.5|
Mineralization | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 3 1 1| 40 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + M M + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Degeneration, Fatty | |
Eosinophilic Focus | X X X X X X X |
Hematopoietic Cell Proliferation | 1 2 3 |
Infiltration Cellular, Mixed Cell | 4 |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Angiectasis | 4 |
Inflammation, Chronic | |
Fat, Hemorrhage | |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
Pharyngeal, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 4 1 |
Hypertrophy | 2 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hypertrophy | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M M + + + M + M I + + M + + + M + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | 4|
Pars Distalis, Hyperplasia | 4 2 3 1 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 1 2 2 1 1 2 1 3 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + M + M + M + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | 1 2 2 1 2 1 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia | 3 |
Endometrium, Metaplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + M + + + + + + M M +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + M + + + M + + + + + + + + + + M + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + M + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M M M + + M + M + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M M M + + + + + + M + M + + + + M +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 3 2 2 3 2 2 1 1 1 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | 2 1 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic, Focal | |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 3 2 2 1 2 2 2 1 2 1 2 2 2 2 3 2 2|
Glands, Hyperplasia | 4 3 4 2 3 3 3 4 2 3 1 2 3 1 3 3 4 3 3 4 4 3 4 2|
Glands, Metaplasia, Squamous | 1 2 2 1 2 1 1 2 1 2 2 2 2 1 1 2 2 1 2 1 1 2 1|
Lateral Wall, Metaplasia, Squamous | 2 1 3 3 1 1 2 1 2 1 2 3 1 2 3 2 3 1 2 1|
Lateral Wall, Necrosis | |
Olfactory Epithelium, Atrophy | 4 4 4 3 3 3 4 4 2 4 2 2 4 3 4 4 4 4 4 3 4 4 3 4 3|
Olfactory Epithelium, Degeneration, | |
Hyaline | 4 2 2 3 2 2 2 1 2 2 2 1 3 2 2 1 3 3 3 2 3 2|
Olfactory Epithelium, Metaplasia | 4 4 4 3 3 4 4 2 4 2 2 4 3 3 4 4 4 4 3 4 4 3 4 3|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 3 2 1 2 1 2 1 1 1|
Respiratory Epithelium, Hyperplasia, | |
Polypoid | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 0| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 4| 4| 4| 4| 4| 3| 4| 5| 4| 4| 4| 9| 4| 2| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
32.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 4 2 1 1 2 1 2 1 3 3 1 1 2 3 2 3 1 2 |
Respiratory Epithelium, Necrosis | |
Respiratory Epithelium, Regeneration | 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2|
Cornea, Degeneration | 4 1 2 2 2 2 2 1 1 2 1 1 2 2 3 |
Cornea, Hyperplasia | 1 1 1 1 |
Cornea, Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Harderian Gland | + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M A + + + + + + M M + + + + + I +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | X | 2 |
Clear Cell Focus | X | 2 |
Degeneration, Fatty | 1 | 1 1.0|
Eosinophilic Focus | X| 8 |
Hematopoietic Cell Proliferation | 3 2 | 5 2.2|
Infiltration Cellular, Mixed Cell | | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Angiectasis | | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Necrosis | 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Pharyngeal, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 4 1 1 1| 9 1.7|
Hypertrophy | | 1 2.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 42 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hypertrophy | 1 | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + I I M M + + + M M M M M + M + M + + M| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 2 3 1 1 2 1 3 1| 17 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 1 4 2 1 1 1 1 2 1 1 2 1 2 1| 30 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + M + + + M + + M + + + M + + + + +| 41 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 2 2.0|
Cyst | 2 3 1 3 4 2 1 1 | 15 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + I + + + + + +| 49 |
Angiectasis | 2 4 | 2 3.0|
Hydrometra | 2 2 3 | 3 2.3|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia | | 1 3.0|
Endometrium, Metaplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + +| 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + M + + M M + M M + + M + + + + M + + + +| 37 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + M + + M + + M M + + + + +| 40 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + M + + + + + + +| 46 |
Angiectasis | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + A + M + + + + + + + + + + + + +| 40 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 2 2 4 2 2 | 17 2.3|
Hyperplasia, Lymphoid | 2 2 4| 5 2.4|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + A + M + + + + + M + M + + + + +| 38 |
Hyperplasia, Lymphoid | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Subcutaneous Tissue, Hemorrhage | 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 1 2 2 1 1 1 2 | 22 1.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Gliosis | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 1 | 4 1.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 | 5 1.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 2 | 3 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 3| 3| 7| 3| 3| 8| 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 5| 5| 3| 5| 5| 5| 5| 5| 5| 9| 5| 5| 9| 4| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
32.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 2 2 2 2 2 3 1 3 2 2 2 3 3 1 3 2 1 1 1 3 2| 42 2.0|
Glands, Hyperplasia | 3 3 4 3 4 4 3 4 3 4 4 3 3 3 4 3 3 4 3 1 2 3 4| 47 3.1|
Glands, Metaplasia, Squamous | 1 2 1 1 1 2 2 1 1 2 2 3 3 2 1 1 2 1 1 1 1 1 2| 46 1.5|
Lateral Wall, Metaplasia, Squamous | 2 2 1 2 2 2 2 3 3 2 2 2 1 1 1 2| 36 1.9|
Lateral Wall, Necrosis | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 4 4 3 4 4 4 3 4 4 3 4 4 3 4 4 4 4 4 4 4 4 3 3 4 4| 50 3.6|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 3 2 2 3 2 2 1 1 2 2 4 3 2 2 3 2 2 3 1 2 2 2| 46 2.2|
Olfactory Epithelium, Metaplasia | 4 4 3 4 4 4 3 4 4 3 4 4 3 4 4 4 4 3 4 4 4 3 3 4 4| 49 3.6|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 2 1 2 2 1 2 1 1 1 1 1 1 2 1 2 2 2 1 1 2 2 1| 48 1.4|
Respiratory Epithelium, Hyperplasia, | | |
Polypoid | 1| 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 1 1 2 2 2 2 3 2 3 3 3 1 1 2 2 1 2| 39 1.9|
Respiratory Epithelium, Necrosis | 2 1 1 | 3 1.3|
Respiratory Epithelium, Regeneration | 1 1 2 1 1 1 2 1 1 | 13 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | | 1 2.0|
Cornea, Degeneration | 2 1 3 3 1 3 3 2 2 3 2 | 26 2.0|
Cornea, Hyperplasia | 1 1 1 | 7 1.0|
Cornea, Inflammation, Chronic Active | 2 | 3 1.7|
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Metaplasia, Osseous | 1 1 | 4 1.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M|
Anus, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2|
Eosinophilic Focus | X X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | |
Necrosis | |
Bile Duct, Cyst | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1|
Hypertrophy | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Atrium, Thrombosis | 3 |
Ventricle, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 3 1|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M M + + M + M + M + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 2|
Inflammation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + + + M M + + + + M + + + M + M M + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M + I + + + M + + + + M M M M + + M + + + M M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + M M M + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M M M + M + + + M + + + + M M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Prepuce, Inflammation, Chronic Active| 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Meninges, Infiltration Cellular, | |
Mononuclear Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 1 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 |
Respiratory Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Squamous | 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 2 |
Inflammation, Chronic Active | |
Cornea, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hydronephrosis | 2 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 2|
Nephropathy | 1 1 1 2 1 1 1 2 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 3| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 8| 9| 2| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 7| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 7| 3| 5| 7| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| |
| 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + A + + + + + + M + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +| 48 |
Anus, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + I + + A + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 2| 5 1.6|
Eosinophilic Focus | X X X | 13 |
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 2 3 | 2 2.5|
Bile Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | 3 2 4 | 7 2.4|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 7 1.0|
Hypertrophy | | 1 1.0|
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Necrosis | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Atrium, Thrombosis | | 1 3.0|
Ventricle, Thrombosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| |
| 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 2 1 1 1 2 1 1 1 2 1 1 1 3 1 3 1| 35 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 9 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M M + + M + M + + + M + M M + +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 1 1 2| 8 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 1.5|
Spermatocele | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 1.7|
Inflammation | 1 | 3 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 1 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + M + M M + M M M M M M + + + + M M +| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + M M + M + + M + M M M M M + M + + + + M +| 28 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M M M + + + + + + + + I + + M +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| |
| 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + M + + M M M M + + + + + + M +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 3.0|
Mineralization | | 1 2.0|
Prepuce, Inflammation, Chronic Active| 2 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Meninges, Infiltration Cellular, | | |
Mononuclear Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 4 2 4 3 | 4 3.3|
Alveolar Epithelium, Hyperplasia | 1 1 1 2| 5 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 7 1.4|
Olfactory Epithelium, Atrophy | 1 1 | 3 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 2 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 | 5 1.0|
Respiratory Epithelium, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Squamous | | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 6| 3| 8| 3| 5| 3| 8| 3| 3| 3| 3| 6| 3| 9| 3| |
| 3| 3| 3| 3| 3| 3| 1| 4| 5| 4| 7| 4| 7| 4| 1| 4| 4| 7| 4| 4| 4| 7| 4| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 2 | 2 2.0|
Inflammation, Chronic Active | 1 2 | 2 1.5|
Cornea, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
Hydronephrosis | 2 | 2 2.0|
Inflammation, Chronic Active | 3 2 | 2 2.5|
Metaplasia, Osseous | 1 1| 3 1.3|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 3 1 1 1 1 1 1 2 2| 49 1.2|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 4 | 3 3.3|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + M + + + + + M + + + + + M + A + + + +|
Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 2 |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | |
Necrosis | 3 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | 4 |
Duct, Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Diverticulum | X |
Hyperkeratosis | |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 |
Hypertrophy | 1 1 1 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 4|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | + M M + M + + + M M + M + I M M + M + + A + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Pars Distalis, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | + |
Inflammation | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | 3 2 2|
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + + + + M + + + + M + M M M A + M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + M + + + + M A + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M + M + + M M + + + + + + A + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + I + + M + + + M M + M M M M A + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M + M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Prepuce, Inflammation, Chronic Active| 4 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 2 1 1|
Glands, Hyperplasia | 1 1 1 1 |
Glands, Metaplasia, Squamous | 1 1 1 1 |
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 1 |
Olfactory Epithelium, Atrophy | 3 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 |
Olfactory Epithelium, Metaplasia | 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Regeneration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 7| 2| 7| 7| 7| 6| 5| 7| 7| 2| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 7| 3| 3| 3| 3| 8| 3| 0| 3| 3| 8| 3| 3| 3| 6| 9| 3| 3| 7| 3| 3| 3| 3|
| 3| 3| 7| 3| 3| 3| 3| 2| 3| 1| 3| 3| 7| 3| 3| 3| 5| 8| 3| 3| 0| 2| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 1 |
Cornea, Inflammation, Chronic Active | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | |
Hydronephrosis | 1 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 1 2 1 2 1 1 1 1 2 3 2 1 1 2 2 2 2 2 3 1 1 1 2|
Renal Tubule, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + M + + + + + + A + + + + + + +| 42 |
Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Peyer's Patch, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 5 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | | 1 2.0|
Eosinophilic Focus | X X X X X X X X X| 18 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis | 2 2 | 4 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 4 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 4.0|
Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | | 1 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 4 3 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
Hypertrophy | 1 3 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 2| 37 1.3|
Capsule, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 2 | 7 1.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + M M + + + + + M + + + + + + + M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 | 4 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 2 1 1 1 1| 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 3 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 3 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M + M + M M M M M + M M M M + + M + + + M| 22 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + M + + M M M + + M + M + M M + M M M| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2| 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M M + + + + + + + + + + + + M + + M +| 39 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 | 12 2.0|
Hyperplasia, Lymphoid | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + M + + + + M + + M M + + M + M + + + + M +| 31 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Prepuce, Inflammation, Chronic Active| | 2 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 1 1.0|
Hyperostosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 4 4 2 | 4 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 1 1 1 1 1 1 | 11 1.2|
Glands, Hyperplasia | 1 1 1 1 1 1 | 10 1.0|
Glands, Metaplasia, Squamous | 1 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 9| 1| 3| 3| 9| 3| 3| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 4| 3| 4| 4| 4| 4| 4| 4| 4| 7| 5| 4| 4| 0| 4| 4| 4| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lateral Wall, Metaplasia, Squamous | 1 1 1 1 | 9 1.0|
Olfactory Epithelium, Atrophy | 1 2 1 1 1 1 1 | 15 1.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 3 1.7|
Olfactory Epithelium, Metaplasia | 1 2 1 1 1 1 | 12 1.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 2 1| 18 1.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 | 2 1.0|
Respiratory Epithelium, Regeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Cataract | | 1 1.0|
Cornea, Inflammation, Chronic Active | | 1 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 3 1 | 3 2.0|
Hydronephrosis | 1 | 2 1.0|
Metaplasia, Osseous | 1 2 | 4 1.3|
Nephropathy | 1 1 3 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 2 1 1 1| 48 1.4|
Renal Tubule, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
Inflammation, Chronic Active | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|
| 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + A + + + + + + + + + + + M A + + + M +|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | |
Necrosis | 1 2 |
Bile Duct, Cyst | 3 |
Centrilobular, Degeneration | 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 1 1 |
Hypertrophy | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1|
Hypertrophy | 1 3 1 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|
| 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 2 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M M + + + + + M M + + + + M + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Mineralization | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + A + + + + + + + + + + + + A + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 1 4 1 |
Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + M M M + M + + + M + + M + + + + M + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M M + M M + M + + + M M + + M + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M + + + + + + + + + + + M M M M + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 |
__________________________________________________________________________|
Thymus | M + + M + + M + + + + M M + M + + M + M + + + + +|
Epithelial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M + M M M M M + M|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|
| 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Prepuce, Inflammation, Chronic Active| 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 4 3 2 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 1 2 1 1 1 1 2 1 1 1 1|
Glands, Hyperplasia | 1 1 1 1 2 2 2 1 2 1 2 1 1 2 2 2 1 2 2 3 2 3 2 2|
Glands, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Lateral Wall, Metaplasia, Squamous | 4 1 1 2 1 |
Lateral Wall, Necrosis | 2 1 |
Olfactory Epithelium, Atrophy | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 2|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 1 1 2 1 1 2|
Olfactory Epithelium, Metaplasia | 2 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 3 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 |
Respiratory Epithelium, Regeneration | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 4| 6| 7| 6| 7| 7| 7| 7| 5| 7| 2| 7| 5| 7| 5| 7| 7| 7| 4| 7|
DAY ON TEST | 0| 3| 5| 9| 3| 8| 6| 3| 3| 3| 3| 3| 3| 0| 3| 8| 3| 4| 1| 3| 3| 3| 3| 7| 3|
| 0| 3| 5| 7| 3| 8| 9| 3| 0| 3| 3| 3| 3| 2| 3| 7| 3| 8| 2| 2| 3| 3| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
8.0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 1 1 |
Cornea, Dysplasia | 1 |
Cornea, Hyperplasia | 1 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Chronic Active | 2 |
Mineralization | |
Nephropathy | 1 1 2 2 2 1 1 1 2 1 2 2 2 2 1 1 1 2 1|
Papilla, Necrosis | |
Renal Tubule, Degeneration | |
Renal Tubule, Hypertrophy | 1 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + I + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| |
DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| |
| 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + M + + + + + + + + + + M +| 42 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + A + + + + + + M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | X | 3 |
Eosinophilic Focus | X X X X X X | 12 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 2 2 4 1 | 6 2.0|
Bile Duct, Cyst | | 1 3.0|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | 3 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Atrophy | 1 1 | 4 1.0|
Hypertrophy | 1 | 2 1.0|
Duct, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 2 | 2 1.5|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| |
DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| |
| 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 5 1.4|
Hypertrophy | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 | 31 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 1 1 1 | 10 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M M + M + M M + M + + + + + + + + M + M +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A M + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 2 2.5|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Cyst | 4 | 2 3.5|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +| 46 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Atrophy | 2 1| 5 1.8|
Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + M M + M M M M + + + + + M M M + M M M| 27 |
Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M + M M M M M M + + + + M M + M M M M + +| 23 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + M + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| |
DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| |
| 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + A + + + M + M + M + + + + + + +| 38 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2| 11 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + A + + + M M + M + + + + + + + M| 36 |
Epithelial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + M + + + + + A + + + + + + + + + + + + + + +| 48 |
Cyst Epithelial Inclusion | X | 1 |
Prepuce, Inflammation, Chronic Active| 4 4| 3 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 2 2.0|
Hyperostosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 1.0|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 4 | 5 3.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 1 2 1 2 1 2 2 2 2 | 27 1.3|
Glands, Hyperplasia | 2 2 2 1 1 3 3 2 3 1 1 3 1 1 2 2 2 1 1 2 1 2 2 2| 48 1.8|
Glands, Metaplasia, Squamous | 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 | 35 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05201-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURYL ALCOHOL Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 21:32:45
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 5| |
DAY ON TEST | 6| 6| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 8| |
| 5| 5| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 4| 4| 1| 4| 4| 4| 4| 6| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
8.0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lateral Wall, Metaplasia, Squamous | 1 1 3 2 1 | 10 1.7|
Lateral Wall, Necrosis | 1 | 3 1.3|
Olfactory Epithelium, Atrophy | 2 2 2 2 2 3 3 3 3 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.2|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 2 2 1 2 1 1 1 1 1| 21 1.3|
Olfactory Epithelium, Metaplasia | 2 2 2 2 2 3 3 3 3 2 2 4 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 2 2 1 2 2 2 2 1 2 1 1 1 2| 42 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 1 1 1 1 | 10 1.1|
Respiratory Epithelium, Regeneration | 1 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Cataract | 2 | 3 1.3|
Cornea, Dysplasia | | 1 1.0|
Cornea, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 1| 1 1.0|
In