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TDMS Study 05201-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97

EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 18:44:56
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000
            

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97     
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 18:44:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000  



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF            FURFURYL ALCOHOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hypertrophy
Kidney: Renal Tubule                   Degeneration
Liver                                  Angiectasis
                                       Basophilic Focus
                                       Degeneration Fatty
                                       Vacuolization Cytoplasmic
Nose                                   Inflammation
Nose: Glands                           Hyperplasia
                                       Metaplasia
Nose: Lateral Wall                     Metaplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
                                       Metaplasia
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
                                       Regeneration
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Epididymis                             Hyperplasia
Eye: Cornea                            Degeneration
                                       Hyperplasia
Heart                                  Cardiomyopathy
Liver                                  Basophilic Focus
                                       Clear Cell Focus
                                       Eosinophilic Focus
                                       Hematopoietic Cell Proliferation
Lymph Node                             Angiectasis
Nose                                   Inflammation
Nose: Glands                           Hyperplasia
                                       Metaplasia
Nose: Lateral Wall                     Metaplasia
Nose: Olfactory Epithelium             Atrophy
                                       Degeneration Hyaline
                                       Metaplasia
Nose: Respiratory Epithelium           Degeneration Hyaline
                                       Metaplasia
                                       Necrosis
                                       Regeneration
Spleen                                 Hematopoietic Cell Proliferation
Stomach, Forestomach: Epithelium       Hyperplasia
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     FURFURYL ALCOHOL                                   DATE: 04/25/97     
EXPERIMENT: 05201 TEST: 06                                                                                     TIME: 18:44:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: N01-ES-15315                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56224C     
PATHOLOGIST: MILLER, RODNEY                                                                                    CAS: 0098-00-0000  

Thyroid Gland: Follicular Cell         Hyperplasia
Uterus                                 Hyperplasia Cystic
===============================================================
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    5/49 (10%)   2/48 (4%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         2.3%         12.8%        4.6%        |0.0%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    1/36 (3%)    4/30 (13%)   2/37 (5%)   |0/34 (0%)    1/33 (3%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      665          733 (T)     |---          497          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.546      P=0.749N     P=0.079      P=0.530     |P=0.365N     P=0.229      (e)          (e)          |
|POLY 3             |     P=0.522      P=0.759      P=0.080      P=0.506     |P=0.375N     P=0.235      (e)          (e)          |
|POLY 1.5           |     P=0.509      P=0.758      P=0.086      P=0.497     |P=0.383N     P=0.233      (e)          (e)          |
|POLY 6             |     P=0.537      P=0.761N     P=0.075      P=0.515     |P=0.365N     P=0.239      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.540      P=0.749N     P=0.074      P=0.530     |P=0.472N     P=0.251      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.490      P=0.747      P=0.098      P=0.485     |P=0.393N     P=0.242      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     35/50 (70%)  37/49 (76%)  31/49 (63%)  28/48 (58%) |4/50 (8%)    1/49 (2%)    3/50 (6%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     78.4%        80.6%        75.4%        62.6%       |9.3%         2.4%         7.0%         6.5%         |
|TERMINAL (d)       |     30/34 (88%)  31/36 (86%)  26/30 (87%)  25/37 (68%) |4/34 (12%)   1/33 (3%)    3/32 (9%)    3/40 (8%)    |
|FIRST INCIDENCE    |     547          433          471          590         |734 (T)      734 (T)      734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.007N**   P=0.573      P=0.584      P=0.027N*   |P=0.567N     P=0.187N     P=0.534N     P=0.411N     |
|POLY 3             |     P=0.017N*    P=0.501      P=0.465N     P=0.069N    |P=0.599      P=0.185N     P=0.502N     P=0.464N     |
|POLY 1.5           |     P=0.031N*    P=0.428      P=0.401N     P=0.100N    |P=0.580      P=0.187N     P=0.500N     P=0.482N     |
|POLY 6             |     P=0.008N**   P=0.584      P=0.533N     P=0.043N*   |P=0.616      P=0.181N     P=0.507N     P=0.444N     |
|LOGISTIC REGRESSION|     P=0.011N*    P=0.380      P=0.593N     P=0.048N*   |P=0.567N     P=0.187N     P=0.534N     P=0.411N     |
|COCH-ARM / FISHERS |     P=0.069N     P=0.349      P=0.310N     P=0.160N    |P=0.546      P=0.187N     P=0.500N     P=0.511N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/48 (0%)    1/48 (2%)   |4/48 (8%)    1/48 (2%)    2/49 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.3%        |9.7%         2.4%         4.7%         8.6%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    1/37 (3%)   |4/33 (12%)   0/32 (0%)    1/31 (3%)    3/40 (8%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |734 (T)      601          666          713          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.245      (e)          (e)          P=0.517     |P=0.438      P=0.188N     P=0.364N     P=0.535N     |
|POLY 3             |     P=0.232      (e)          (e)          P=0.503     |P=0.382      P=0.175N     P=0.325N     P=0.580N     |
|POLY 1.5           |     P=0.229      (e)          (e)          P=0.499     |P=0.366      P=0.178N     P=0.326N     P=0.600N     |
|POLY 6             |     P=0.235      (e)          (e)          P=0.509     |P=0.397      P=0.169N     P=0.327N     P=0.557N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.517     |P=0.385      P=0.180N     P=0.336N     P=0.540N     |
|COCH-ARM / FISHERS |     P=0.223      (e)          (e)          P=0.490     |P=0.336      P=0.181N     P=0.329N     P=0.631N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |16/50 (32%)  19/49 (39%)  15/50 (30%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         5.0%         0.0%        |36.0%        44.7%        34.3%        46.7%        |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    0/30 (0%)    0/38 (0%)   |12/34 (35%)  18/33 (55%)  12/32 (38%)  21/40 (53%)  |
|FIRST INCIDENCE    |     ---          733 (T)      576          ---         |547          649          632          609          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.442N     P=0.511      P=0.216      (e)         |P=0.394      P=0.296      P=0.568N     P=0.334      |
|POLY 3             |     P=0.450N     P=0.499      P=0.219      (e)         |P=0.217      P=0.268      P=0.524N     P=0.200      |
|POLY 1.5           |     P=0.459N     P=0.498      P=0.225      (e)         |P=0.190      P=0.279      P=0.512N     P=0.182      |
|POLY 6             |     P=0.440N     P=0.500      P=0.214      (e)         |P=0.243      P=0.263      P=0.546N     P=0.217      |
|LOGISTIC REGRESSION|     P=0.478N     P=0.511      P=0.252      (e)         |P=0.284      P=0.310      P=0.508N     P=0.245      |
|COCH-ARM / FISHERS |     P=0.473N     P=0.500      P=0.247      (e)         |P=0.147      P=0.310      P=0.500N     P=0.151      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     4.6%         4.6%         0.0%         2.2%        |0.0%         0.0%         2.4%         2.2%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     537          287          ---          716         |---          ---          693          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.402N     P=0.690      P=0.281N     P=0.469N    |P=0.392      (e)          P=0.489      P=0.532      |
|POLY 3             |     P=0.412N     P=0.694N     P=0.264N     P=0.485N    |P=0.376      (e)          P=0.496      P=0.513      |
|POLY 1.5           |     P=0.421N     P=0.692      P=0.256N     P=0.491N    |P=0.365      (e)          P=0.496      P=0.507      |
|POLY 6             |     P=0.402N     P=0.693N     P=0.274N     P=0.478N    |P=0.385      (e)          P=0.496      P=0.520      |
|LOGISTIC REGRESSION|     P=0.501N     P=0.694N     P=0.200N     P=0.537N    |P=0.365      (e)          P=0.496      P=0.532      |
|COCH-ARM / FISHERS |     P=0.433N     P=0.684      P=0.253N     P=0.500N    |P=0.346      (e)          P=0.495      P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    2/49 (4%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.7%         2.4%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          525          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.335N     P=0.227      P=0.488      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.343N     P=0.236      P=0.496      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.354N     P=0.233      P=0.496      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.331N     P=0.241      P=0.494      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.422N     P=0.254      P=0.488      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.369N     P=0.242      P=0.495      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain: Meninges                                                                                                                  |
|     Infiltration Cellular Mononuclear Cell                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |4/50 (8%)    4/49 (8%)    2/49 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         0.0%         0.0%        |9.2%         9.5%         4.7%         8.5%         |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |3/34 (9%)    4/33 (12%)   2/32 (6%)    2/40 (5%)    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |693          734 (T)      734 (T)      600          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.528N     P=0.489N     P=0.525N     P=0.478N    |P=0.530N     P=0.627      P=0.365N     P=0.558N     |
|POLY 3             |     P=0.536N     P=0.501N     P=0.520N     P=0.488N    |P=0.592N     P=0.629      P=0.349N     P=0.600N     |
|POLY 1.5           |     P=0.539N     P=0.502N     P=0.514N     P=0.493N    |P=0.593      P=0.627      P=0.347N     P=0.621N     |
|POLY 6             |     P=0.532N     P=0.500N     P=0.526N     P=0.482N    |P=0.566N     P=0.634      P=0.353N     P=0.575N     |
|LOGISTIC REGRESSION|     P=0.528N     (e)          (e)          (e)         |P=0.591N     P=0.644N     P=0.357N     P=0.635      |
|COCH-ARM / FISHERS |     P=0.546N     P=0.500N     P=0.505N     P=0.500N    |P=0.554      P=0.631      P=0.349N     P=0.631      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/49 (4%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.1%         0.0%        |                                                    |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/38 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          576          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.622N     (e)          P=0.218      (e)         |                                                    |
|POLY 3             |     P=0.634N     (e)          P=0.218      (e)         |                                                    |
|POLY 1.5           |     P=0.640N     (e)          P=0.223      (e)         |                                                    |
|POLY 6             |     P=0.627N     (e)          P=0.213      (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.670N     (e)          P=0.242      (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.651N     (e)          P=0.242      (e)         |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.6%         2.3%         0.0%         4.4%        |                                                    |
|TERMINAL (d)       |     1/34 (3%)    1/36 (3%)    0/30 (0%)    2/38 (5%)   |                                                    |
|FIRST INCIDENCE    |     721          733 (T)      ---          733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.520      P=0.484N     P=0.271N     P=0.653N    |                                                    |
|POLY 3             |     P=0.507      P=0.502N     P=0.260N     P=0.673N    |                                                    |
|POLY 1.5           |     P=0.497      P=0.503N     P=0.253N     P=0.681N    |                                                    |
|POLY 6             |     P=0.518      P=0.500N     P=0.267N     P=0.663N    |                                                    |
|LOGISTIC REGRESSION|     P=0.528      P=0.496N     P=0.270N     P=0.654N    |                                                    |
|COCH-ARM / FISHERS |     P=0.480      P=0.500N     P=0.253N     P=0.691N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Spermatocele                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     2/34 (6%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.293N     P=0.226N     P=0.266N     P=0.214N    |                                                    |
|POLY 3             |     P=0.293N     P=0.238N     P=0.260N     P=0.224N    |                                                    |
|POLY 1.5           |     P=0.298N     P=0.239N     P=0.253N     P=0.229N    |                                                    |
|POLY 6             |     P=0.288N     P=0.236N     P=0.267N     P=0.218N    |                                                    |
|LOGISTIC REGRESSION|     P=0.293N     (e)          (e)          (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.308N     P=0.247N     P=0.253N     P=0.247N    |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/48 (2%)    3/49 (6%)    0/49 (0%)   |2/49 (4%)    1/49 (2%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.6%         2.4%         7.5%         0.0%        |4.7%         2.3%         0.0%         2.1%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/38 (0%)   |2/34 (6%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     567          598          400          ---         |734 (T)      448          ---          600          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.191N     P=0.492N     P=0.441      P=0.217N    |P=0.518N     P=0.509N     P=0.252N     P=0.449N     |
|POLY 3             |     P=0.194N     P=0.512N     P=0.459      P=0.232N    |P=0.537N     P=0.500N     P=0.241N     P=0.468N     |
|POLY 1.5           |     P=0.200N     P=0.513N     P=0.471      P=0.236N    |P=0.544N     P=0.502N     P=0.239N     P=0.478N     |
|POLY 6             |     P=0.189N     P=0.510N     P=0.446      P=0.228N    |P=0.529N     P=0.495N     P=0.243N     P=0.457N     |
|LOGISTIC REGRESSION|     P=0.238N     P=0.507N     P=0.569      P=0.267N    |P=0.659N     P=0.467N     (e)          P=0.521N     |
|COCH-ARM / FISHERS |     P=0.209N     P=0.515N     P=0.490      P=0.253N    |P=0.556N     P=0.500N     P=0.247N     P=0.492N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    0/49 (0%)    1/49 (2%)   |0/49 (0%)    1/49 (2%)    2/49 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         2.2%        |0.0%         2.4%         4.7%         0.0%         |
|TERMINAL (d)       |     2/34 (6%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      ---          ---          707         |---          721          604          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.673N     P=0.226N     P=0.266N     P=0.454N    |P=0.433N     P=0.511      P=0.243      (e)          |
|POLY 3             |     P=0.702N     P=0.243N     P=0.260N     P=0.486N    |P=0.442N     P=0.497      P=0.235      (e)          |
|POLY 1.5           |     P=0.708N     P=0.245N     P=0.253N     P=0.495N    |P=0.451N     P=0.497      P=0.236      (e)          |
|POLY 6             |     P=0.696N     P=0.241N     P=0.267N     P=0.475N    |P=0.433N     P=0.499      P=0.234      (e)          |
|LOGISTIC REGRESSION|     P=0.685N     (e)          (e)          P=0.476N    |P=0.478N     P=0.498      P=0.241      (e)          |
|COCH-ARM / FISHERS |     P=0.699      P=0.258N     P=0.253N     P=0.508N    |P=0.467N     P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |3/49 (6%)    1/49 (2%)    4/49 (8%)    26/50 (52%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |7.0%         2.4%         9.5%         54.6%        |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |3/34 (9%)    1/33 (3%)    4/32 (13%)   22/40 (55%)  |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      734 (T)      734 (T)      609          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.315N     P=0.466      P<0.001 **   |
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.312N     P=0.491      P<0.001 **   |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.311N     P=0.495      P<0.001 **   |
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.308N     P=0.484      P<0.001 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.315N     P=0.466      P<0.001 **   |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.309N     P=0.500      P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/48 (0%)    2/49 (4%)    1/49 (2%)   |2/49 (4%)    0/49 (0%)    4/49 (8%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         5.1%         2.2%        |4.7%         0.0%         9.5%         14.9%        |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    2/30 (7%)    1/38 (3%)   |2/34 (6%)    0/33 (0%)    4/32 (13%)   6/40 (15%)   |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      733 (T)     |734 (T)      ---          734 (T)      609          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.625      P=0.489N     P=0.456      P=0.737N    |P=0.020 *    P=0.245N     P=0.308      P=0.125      |
|POLY 3             |     P=0.613      P=0.506N     P=0.465      P=0.752N    |P=0.012 *    P=0.241N     P=0.329      P=0.102      |
|POLY 1.5           |     P=0.605      P=0.507N     P=0.475      P=0.757N    |P=0.010 *    P=0.241N     P=0.333      P=0.095      |
|POLY 6             |     P=0.621      P=0.504N     P=0.455      P=0.746N    |P=0.013 *    P=0.239N     P=0.323      P=0.112      |
|LOGISTIC REGRESSION|     P=0.625      (e)          P=0.456      P=0.737N    |P=0.015 *    (e)          P=0.308      P=0.103      |
|COCH-ARM / FISHERS |     P=0.593      P=0.510N     P=0.492      P=0.747     |P=0.009 **   P=0.247N     P=0.339      P=0.085      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Cornea                                                                                                                      |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/48 (2%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    0/49 (0%)    1/49 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         0.0%         0.0%        |2.3%         0.0%         2.4%         6.4%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    3/40 (8%)    |
|FIRST INCIDENCE    |     ---          632          ---          ---         |712          ---          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.585N     P=0.495      (e)          (e)         |P=0.121      P=0.500N     P=0.740      P=0.363      |
|POLY 3             |     P=0.594N     P=0.496      (e)          (e)         |P=0.096      P=0.504N     P=0.757      P=0.335      |
|POLY 1.5           |     P=0.600N     P=0.494      (e)          (e)         |P=0.092      P=0.504N     P=0.758      P=0.326      |
|POLY 6             |     P=0.586N     P=0.499      (e)          (e)         |P=0.100      P=0.503N     P=0.754      P=0.344      |
|LOGISTIC REGRESSION|     P=0.631N     P=0.495      (e)          (e)         |P=0.110      P=0.503N     P=0.755      P=0.350      |
|COCH-ARM / FISHERS |     P=0.609N     P=0.490      (e)          (e)         |P=0.084      P=0.500N     P=0.753N     P=0.316      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Gallbladder                                                                                                                      |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/42 (0%)    0/42 (0%)    0/43 (0%)   |0/43 (0%)    2/45 (4%)    0/47 (0%)    0/41 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         5.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/32 (0%)    0/33 (0%)    0/28 (0%)    0/36 (0%)   |0/31 (0%)    1/31 (3%)    0/32 (0%)    0/34 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          687          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.367N     P=0.237      (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.396N     P=0.244      (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.401N     P=0.244      (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.389N     P=0.245      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.395N     P=0.244      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.259      (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  47/50 (94%)  43/50 (86%)  45/50 (90%) |36/50 (72%)  40/49 (82%)  46/49 (94%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     92.0%        97.7%        93.6%        91.5%       |77.5%        85.3%        94.7%        86.2%        |
|TERMINAL (d)       |     30/34 (88%)  35/36 (97%)  28/30 (93%)  34/38 (90%) |27/34 (79%)  29/33 (88%)  30/32 (94%)  35/40 (88%)  |
|FIRST INCIDENCE    |     385          433          455          382         |547          441          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.144N     P=0.501N     P=0.405      P=0.210N    |P=0.250N     P=0.226      P=0.032 *    P=0.573      |
|POLY 3             |     P=0.333N     P=0.206      P=0.540      P=0.608N    |P=0.355      P=0.231      P=0.010 *    P=0.190      |
|POLY 1.5           |     P=0.342N     P=0.256      P=0.606N     P=0.576N    |P=0.318      P=0.198      P=0.006 **   P=0.159      |
|POLY 6             |     P=0.336N     P=0.193      P=0.428      P=0.627N    |P=0.376      P=0.284      P=0.018 *    P=0.224      |
|LOGISTIC REGRESSION|     P=0.248N     P=0.442      P=0.432N     P=0.502N    |P=0.375      P=0.153      P=0.004 **   P=0.253      |
|COCH-ARM / FISHERS |     P=0.421N     P=0.500      P=0.262N     P=0.500N    |P=0.236      P=0.185      P=0.004 **   P=0.114      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   7/49 (14%)   10/48 (21%)  5/48 (10%)  |2/49 (4%)    1/48 (2%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     20.1%        16.3%        24.5%        11.1%       |4.7%         2.4%         4.7%         0.0%         |
|TERMINAL (d)       |     6/34 (18%)   7/36 (19%)   7/30 (23%)   3/38 (8%)   |1/33 (3%)    0/33 (0%)    1/32 (3%)    0/40 (0%)    |
|FIRST INCIDENCE    |     547          733 (T)      455          413         |715          601          621          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.137N     P=0.352N     P=0.397      P=0.153N    |P=0.184N     P=0.497N     P=0.687      P=0.205N     |
|POLY 3             |     P=0.152N     P=0.428N     P=0.411      P=0.187N    |P=0.191N     P=0.499N     P=0.691N     P=0.218N     |
|POLY 1.5           |     P=0.170N     P=0.421N     P=0.430      P=0.198N    |P=0.197N     P=0.504N     P=0.692N     P=0.225N     |
|POLY 6             |     P=0.134N     P=0.438N     P=0.389      P=0.176N    |P=0.184N     P=0.491N     P=0.692N     P=0.211N     |
|LOGISTIC REGRESSION|     P=0.208N     P=0.404N     P=0.486      P=0.248N    |P=0.222N     P=0.507N     P=0.695N     P=0.209N     |
|COCH-ARM / FISHERS |     P=0.199N     P=0.410N     P=0.460      P=0.217N    |P=0.210N     P=0.508N     P=0.691N     P=0.247N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.157N     P=0.325      P=0.525N     P=0.478N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.152N     P=0.303      P=0.520N     P=0.488N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.159N     P=0.300      P=0.514N     P=0.493N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.144N     P=0.305      P=0.526N     P=0.482N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.157N     P=0.325      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.170N     P=0.301      P=0.505N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         4.5%         2.5%         4.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     721          287          582          582         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.621N     P=0.684N     P=0.544N     P=0.652N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.633N     P=0.685N     P=0.531N     P=0.665N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.634      P=0.691N     P=0.523N     P=0.677N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.618N     P=0.679N     P=0.539N     P=0.650N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.540      P=0.696N     P=0.510N     P=0.665     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.617      P=0.684      P=0.508N     P=0.691N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         2.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     537          ---          630          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.285N     P=0.245N     P=0.543N     P=0.230N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.284N     P=0.243N     P=0.539N     P=0.228N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.289N     P=0.243N     P=0.527N     P=0.232N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.278N     P=0.244N     P=0.551N     P=0.225N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.325N     P=0.228N     P=0.440N     P=0.271N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.298N     P=0.253N     P=0.508N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/49 (8%)    0/49 (0%)    4/50 (8%)   |1/50 (2%)    3/48 (6%)    2/49 (4%)    4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     7.0%         9.3%         0.0%         8.7%        |2.3%         7.2%         4.7%         8.7%         |
|TERMINAL (d)       |     3/34 (9%)    4/36 (11%)   0/30 (0%)    4/38 (11%)  |1/34 (3%)    3/33 (9%)    1/32 (3%)    4/40 (10%)   |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |734 (T)      734 (T)      632          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.479      P=0.532      P=0.143N     P=0.561     |P=0.285      P=0.294      P=0.494      P=0.231      |
|POLY 3             |     P=0.463      P=0.496      P=0.137N     P=0.533     |P=0.236      P=0.294      P=0.495      P=0.199      |
|POLY 1.5           |     P=0.447      P=0.493      P=0.132N     P=0.519     |P=0.222      P=0.291      P=0.495      P=0.189      |
|POLY 6             |     P=0.481      P=0.501      P=0.143N     P=0.548     |P=0.250      P=0.300      P=0.495      P=0.211      |
|LOGISTIC REGRESSION|     P=0.479      P=0.532      (e)          P=0.561     |P=0.253      P=0.294      P=0.493      P=0.231      |
|COCH-ARM / FISHERS |     P=0.424      P=0.489      P=0.125N     P=0.500     |P=0.200      P=0.293      P=0.492      P=0.175      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  48/49 (98%)  43/49 (88%)  47/50 (94%) |41/50 (82%)  35/48 (73%)  40/49 (82%)  39/49 (80%)  |
|POLY-3 ADJUSTED (b)|     98.5%        99.9%        95.2%        96.3%       |88.3%        81.0%        83.8%        81.3%        |
|TERMINAL (d)       |     34/34 (100%) 36/36 (100%) 30/30 (100%) 38/38 (100%)|31/34 (91%)  29/33 (88%)  26/32 (81%)  34/40 (85%)  |
|FIRST INCIDENCE    |     385          433          455          413         |547          601          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.112N     P=0.340N     P=0.547N     P=0.109N    |P=0.097N     P=0.197N     P=0.529      P=0.069N     |
|POLY 3             |     P=0.282N     P=0.677      P=0.327N     P=0.477N    |P=0.341N     P=0.235N     P=0.365N     P=0.246N     |
|POLY 1.5           |     P=0.287N     P=0.675      P=0.160N     P=0.412N    |P=0.441N     P=0.223N     P=0.449N     P=0.325N     |
|POLY 6             |     P=0.283N     P=0.810      P=0.618N     P=0.533N    |P=0.269N     P=0.249N     P=0.286N     P=0.188N     |
|LOGISTIC REGRESSION|     P=0.147N     P=0.737      P=0.121N     P=0.239N    |P=0.334N     P=0.128N     P=0.581N     P=0.187N     |
|COCH-ARM / FISHERS |     P=0.332N     P=0.747N     P=0.053N     P=0.309N    |P=0.500      P=0.202N     P=0.584N     P=0.480N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/49 (2%)    48/50 (96%) |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         97.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    38/38 (100%)|0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          471          413         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   (e)          P=0.492      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   (e)          P=0.484      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   (e)          P=0.488      P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   (e)          P=0.479      P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.637      P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P=0.495      P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         7.0%         0.0%         6.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          646         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.358      P=0.325      P=0.525N     P=0.343     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.346      P=0.303      P=0.520N     P=0.330     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.332      P=0.300      P=0.514N     P=0.319     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.363      P=0.305      P=0.526N     P=0.342     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.355      P=0.325      (e)          P=0.320     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.314      P=0.301      P=0.505N     P=0.309     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    2/49 (4%)    1/48 (2%)   |5/49 (10%)   9/49 (18%)   3/50 (6%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     4.6%         2.3%         5.0%         2.3%        |11.6%        21.2%        6.9%         10.7%        |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    0/30 (0%)    0/37 (0%)   |4/33 (12%)   6/33 (18%)   2/32 (6%)    3/40 (8%)    |
|FIRST INCIDENCE    |     484          582          471          582         |352          684          693          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.459N     P=0.490N     P=0.658      P=0.475N    |P=0.261N     P=0.200      P=0.374N     P=0.525N     |
|POLY 3             |     P=0.477N     P=0.504N     P=0.664      P=0.496N    |P=0.315N     P=0.181      P=0.354N     P=0.575N     |
|POLY 1.5           |     P=0.486N     P=0.506N     P=0.672      P=0.504N    |P=0.342N     P=0.181      P=0.351N     P=0.598N     |
|POLY 6             |     P=0.466N     P=0.501N     P=0.657      P=0.486N    |P=0.283N     P=0.189      P=0.358N     P=0.547N     |
|LOGISTIC REGRESSION|     P=0.588N     P=0.496N     P=0.581N     P=0.569N    |P=0.362N     P=0.191      P=0.346N     P=0.506      |
|COCH-ARM / FISHERS |     P=0.500N     P=0.508N     P=0.684      P=0.515N    |P=0.383N     P=0.194      P=0.346N     P=0.630N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx                                                                                                                           |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    1/49 (2%)    0/48 (0%)   |0/49 (0%)    3/49 (6%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         2.5%         0.0%        |0.0%         7.1%         0.0%         2.2%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/37 (0%)   |0/33 (0%)    1/33 (3%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     484          ---          532          ---         |---          721          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.469N     P=0.504N     P=0.738      P=0.500N    |P=0.560N     P=0.127      (e)          P=0.538      |
|POLY 3             |     P=0.473N     P=0.505N     P=0.738      P=0.500N    |P=0.603N     P=0.118      (e)          P=0.518      |
|POLY 1.5           |     P=0.478N     P=0.505N     P=0.744      P=0.504N    |P=0.613N     P=0.118      (e)          P=0.511      |
|POLY 6             |     P=0.468N     P=0.504N     P=0.732      P=0.496N    |P=0.588N     P=0.121      (e)          P=0.525      |
|LOGISTIC REGRESSION|     P=0.553N     P=0.445N     P=0.661N     P=0.534N    |P=0.571N     P=0.124      (e)          P=0.538      |
|COCH-ARM / FISHERS |     P=0.485N     P=0.505N     P=0.747      P=0.510N    |P=0.625N     P=0.121      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    2/38 (5%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054      (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.048 *    (e)          (e)          P=0.257     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.043 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    5/50 (10%)   0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         11.6%        0.0%         0.0%        |0.0%         0.0%         0.0%         4.3%         |
|TERMINAL (d)       |     0/34 (0%)    4/36 (11%)   0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     ---          715          ---          ---         |---          ---          ---          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.039 *    (e)          (e)         |P=0.060      (e)          (e)          P=0.277      |
|POLY 3             |     P=0.117N     P=0.030 *    (e)          (e)         |P=0.046 *    (e)          (e)          P=0.254      |
|POLY 1.5           |     P=0.124N     P=0.030 *    (e)          (e)         |P=0.044 *    (e)          (e)          P=0.245      |
|POLY 6             |     P=0.109N     P=0.030 *    (e)          (e)         |P=0.049 *    (e)          (e)          P=0.263      |
|LOGISTIC REGRESSION|     P=0.122N     P=0.033 *    (e)          (e)         |P=0.041 *    (e)          (e)          P=0.220      |
|COCH-ARM / FISHERS |     P=0.140N     P=0.028 *    (e)          (e)         |P=0.041 *    (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    3/49 (6%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         7.0%         7.7%         2.2%        |0.0%         0.0%         0.0%         4.3%         |
|TERMINAL (d)       |     0/34 (0%)    3/36 (8%)    3/30 (10%)   1/38 (3%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    2/40 (5%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      733 (T)     |---          ---          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.459N     P=0.131      P=0.099      P=0.522     |P=0.062      (e)          (e)          P=0.275      |
|POLY 3             |     P=0.470N     P=0.117      P=0.101      P=0.512     |P=0.046 *    (e)          (e)          P=0.252      |
|POLY 1.5           |     P=0.484N     P=0.117      P=0.106      P=0.507     |P=0.044 *    (e)          (e)          P=0.245      |
|POLY 6             |     P=0.455N     P=0.118      P=0.096      P=0.518     |P=0.048 *    (e)          (e)          P=0.261      |
|LOGISTIC REGRESSION|     (e)          P=0.131      P=0.099      P=0.522     |(e)          (e)          (e)          P=0.275      |
|COCH-ARM / FISHERS |     P=0.505N     P=0.121      P=0.117      P=0.500     |P=0.041 *    (e)          (e)          P=0.242      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Fatty                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    1/49 (2%)    1/49 (2%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     11.6%        2.3%         0.0%         2.2%        |2.3%         2.3%         2.3%         2.2%         |
|TERMINAL (d)       |     5/34 (15%)   1/36 (3%)    0/30 (0%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |596          441          604          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.178N     P=0.089N     P=0.044N*    P=0.079N    |P=0.648N     P=0.758      P=0.743N     P=0.732N     |
|POLY 3             |     P=0.178N     P=0.102N     P=0.039N*    P=0.088N    |P=0.663N     P=0.757      P=0.756      P=0.748N     |
|POLY 1.5           |     P=0.186N     P=0.103N     P=0.037N*    P=0.093N    |P=0.671N     P=0.756      P=0.756      P=0.754N     |
|POLY 6             |     P=0.170N     P=0.100N     P=0.042N*    P=0.082N    |P=0.655N     P=0.760      P=0.754      P=0.741N     |
|LOGISTIC REGRESSION|     P=0.178N     P=0.089N     (e)          P=0.079N    |P=0.541      P=0.711N     P=0.755      P=0.715      |
|COCH-ARM / FISHERS |     P=0.203N     P=0.102N     P=0.030N*    P=0.102N    |P=0.680      P=0.747      P=0.747      P=0.747      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/50 (26%)  18/50 (36%)  12/49 (24%)  14/50 (28%) |14/50 (28%)  19/49 (39%)  20/49 (41%)  8/49 (16%)   |
|POLY-3 ADJUSTED (b)|     30.2%        41.5%        30.4%        30.2%       |31.3%        44.2%        45.5%        17.1%        |
|TERMINAL (d)       |     13/34 (38%)  17/36 (47%)  11/30 (37%)  12/38 (32%) |9/34 (27%)   13/33 (39%)  14/32 (44%)  7/40 (18%)   |
|FIRST INCIDENCE    |     733 (T)      574          576          582         |547          649          632          582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.310N     P=0.235      P=0.546      P=0.542N    |P=0.006N**   P=0.197      P=0.131      P=0.063N     |
|POLY 3             |     P=0.340N     P=0.188      P=0.586      P=0.590     |P=0.006N**   P=0.150      P=0.120      P=0.088N     |
|POLY 1.5           |     P=0.390N     P=0.184      P=0.576N     P=0.552     |P=0.009N**   P=0.155      P=0.123      P=0.100N     |
|POLY 6             |     P=0.286N     P=0.197      P=0.563      P=0.548N    |P=0.005N**   P=0.152      P=0.118      P=0.079N     |
|LOGISTIC REGRESSION|     P=0.305N     P=0.184      P=0.517      P=0.563N    |P=0.008N**   P=0.170      P=0.126      P=0.110N     |
|COCH-ARM / FISHERS |     P=0.465N     P=0.194      P=0.523N     P=0.500     |P=0.019N*    P=0.178      P=0.129      P=0.124N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/49 (2%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    5/49 (10%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     4.6%         2.3%         2.6%         2.2%        |2.3%         0.0%         11.2%        10.8%        |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    4/40 (10%)   |
|FIRST INCIDENCE    |     687          693          712          733 (T)     |604          ---          411          689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.473N     P=0.497N     P=0.561N     P=0.464N    |P=0.067      P=0.505N     P=0.115      P=0.143      |
|POLY 3             |     P=0.494N     P=0.503N     P=0.537N     P=0.481N    |P=0.050      P=0.507N     P=0.107      P=0.116      |
|POLY 1.5           |     P=0.504N     P=0.503N     P=0.526N     P=0.489N    |P=0.045 *    P=0.507N     P=0.104      P=0.109      |
|POLY 6             |     P=0.485N     P=0.501N     P=0.548N     P=0.473N    |P=0.056      P=0.506N     P=0.108      P=0.124      |
|LOGISTIC REGRESSION|     P=0.498N     P=0.502N     P=0.532N     P=0.485N    |P=0.009 **   P=0.480N     P=0.073      P=0.096      |
|COCH-ARM / FISHERS |     P=0.520N     P=0.500N     P=0.508N     P=0.500N    |P=0.038 *    P=0.505N     P=0.098      P=0.098      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    4/49 (8%)    4/49 (8%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         2.6%         4.3%        |0.0%         9.2%         9.2%         2.2%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/30 (3%)    0/38 (0%)   |0/34 (0%)    2/33 (6%)    1/32 (3%)    1/40 (3%)    |
|FIRST INCIDENCE    |     687          ---          733 (T)      637         |---          457          411          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.288      P=0.505N     P=0.721      P=0.542     |P=0.333N     P=0.064      P=0.064      P=0.532      |
|POLY 3             |     P=0.263      P=0.502N     P=0.737      P=0.523     |P=0.345N     P=0.060      P=0.061      P=0.513      |
|POLY 1.5           |     P=0.254      P=0.502N     P=0.744      P=0.513     |P=0.363N     P=0.059      P=0.060      P=0.507      |
|POLY 6             |     P=0.273      P=0.501N     P=0.729      P=0.534     |P=0.325N     P=0.063      P=0.062      P=0.520      |
|LOGISTIC REGRESSION|     P=0.244      P=0.500N     P=0.740      P=0.484     |P=0.530N     P=0.066      P=0.055      P=0.532      |
|COCH-ARM / FISHERS |     P=0.239      P=0.500N     P=0.747      P=0.500     |P=0.394N     P=0.056      P=0.056      P=0.495      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Focal Granulomatous                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    2/49 (4%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         4.7%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |1/34 (3%)    2/33 (6%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |734 (T)      734 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.209N     P=0.490      P=0.512N     P=0.468N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.228N     P=0.492      P=0.504N     P=0.487N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.234N     P=0.490      P=0.504N     P=0.493N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.221N     P=0.496      P=0.506N     P=0.480N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.209N     P=0.490      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.492      P=0.505N     P=0.505N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    6/49 (12%)   2/50 (4%)   |2/50 (4%)    1/49 (2%)    4/49 (8%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     4.6%         9.2%         14.5%        4.3%        |4.5%         2.3%         9.3%         4.3%         |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    1/30 (3%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    2/40 (5%)    |
|FIRST INCIDENCE    |     687          598          471          637         |352          601          617          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.317N     P=0.352      P=0.106      P=0.651N    |P=0.592N     P=0.511N     P=0.335      P=0.652N     |
|POLY 3             |     P=0.327N     P=0.338      P=0.117      P=0.672N    |P=0.627N     P=0.513N     P=0.325      P=0.679N     |
|POLY 1.5           |     P=0.344N     P=0.335      P=0.120      P=0.681N    |P=0.613      P=0.513N     P=0.326      P=0.688N     |
|POLY 6             |     P=0.311N     P=0.343      P=0.116      P=0.662N    |P=0.614N     P=0.509N     P=0.325      P=0.668N     |
|LOGISTIC REGRESSION|     P=0.418N     P=0.336      P=0.168      P=0.689     |P=0.463      P=0.425N     P=0.316      P=0.503      |
|COCH-ARM / FISHERS |     P=0.371N     P=0.339      P=0.128      P=0.691N    |P=0.585      P=0.508N     P=0.329      P=0.684      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         0.0%         6.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    0/30 (0%)    3/38 (8%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      ---          733 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055      P=0.511      (e)          P=0.141     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.046 *    P=0.499      (e)          P=0.130     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.044 *    P=0.498      (e)          P=0.125     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.049 *    P=0.500      (e)          P=0.135     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.511      (e)          P=0.141     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.041 *    P=0.500      (e)          P=0.121     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/49 (2%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         2.6%         4.4%        |0.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    1/30 (3%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          733 (T)      733 (T)      707         |---          ---          639          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.257      P=0.511      P=0.475      P=0.272     |P=0.752N     (e)          P=0.500      (e)          |
|POLY 3             |     P=0.236      P=0.499      P=0.480      P=0.251     |P=0.757N     (e)          P=0.497      (e)          |
|POLY 1.5           |     P=0.228      P=0.498      P=0.486      P=0.245     |P=0.761N     (e)          P=0.497      (e)          |
|POLY 6             |     P=0.245      P=0.500      P=0.474      P=0.258     |P=0.752N     (e)          P=0.497      (e)          |
|LOGISTIC REGRESSION|     P=0.253      P=0.511      P=0.475      P=0.253     |P=0.820N     (e)          P=0.493      (e)          |
|COCH-ARM / FISHERS |     P=0.215      P=0.500      P=0.495      P=0.247     |P=0.770N     (e)          P=0.495      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    5/49 (10%)   7/50 (14%)  |3/50 (6%)    5/49 (10%)   2/49 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     9.2%         9.2%         12.6%        15.2%       |6.7%         11.5%        4.7%         6.4%         |
|TERMINAL (d)       |     3/34 (9%)    3/36 (8%)    3/30 (10%)   5/38 (13%)  |1/34 (3%)    3/33 (9%)    1/32 (3%)    2/40 (5%)    |
|FIRST INCIDENCE    |     687          497          548          707         |448          448          639          579          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.254      P=0.620N     P=0.417      P=0.338     |P=0.397N     P=0.334      P=0.515N     P=0.609N     |
|POLY 3             |     P=0.216      P=0.640N     P=0.445      P=0.296     |P=0.435N     P=0.344      P=0.521N     P=0.636N     |
|POLY 1.5           |     P=0.202      P=0.643      P=0.460      P=0.282     |P=0.449N     P=0.342      P=0.516N     P=0.646N     |
|POLY 6             |     P=0.233      P=0.635N     P=0.430      P=0.314     |P=0.420N     P=0.350      P=0.527N     P=0.624N     |
|LOGISTIC REGRESSION|     P=0.212      P=0.641      P=0.441      P=0.312     |P=0.608      P=0.389      P=0.517N     P=0.453      |
|COCH-ARM / FISHERS |     P=0.180      P=0.643N     P=0.487      P=0.262     |P=0.471N     P=0.346      P=0.510N     P=0.661N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    2/49 (4%)    2/50 (4%)   |2/50 (4%)    0/49 (0%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     11.4%        4.6%         5.0%         4.4%        |4.6%         0.0%         2.4%         4.3%         |
|TERMINAL (d)       |     4/34 (12%)   1/36 (3%)    1/30 (3%)    2/38 (5%)   |2/34 (6%)    0/33 (0%)    0/32 (0%)    2/40 (5%)    |
|FIRST INCIDENCE    |     484          632          471          733 (T)     |734 (T)      ---          665          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.280N     P=0.206N     P=0.265N     P=0.181N    |P=0.464      P=0.245N     P=0.511N     P=0.635N     |
|POLY 3             |     P=0.286N     P=0.221N     P=0.257N     P=0.198N    |P=0.430      P=0.242N     P=0.506N     P=0.666N     |
|POLY 1.5           |     P=0.297N     P=0.222N     P=0.245N     P=0.206N    |P=0.420      P=0.243N     P=0.506N     P=0.676N     |
|POLY 6             |     P=0.275N     P=0.217N     P=0.269N     P=0.189N    |P=0.438      P=0.239N     P=0.506N     P=0.655N     |
|LOGISTIC REGRESSION|     P=0.324N     P=0.216N     P=0.206N     P=0.214N    |P=0.437      (e)          P=0.508N     P=0.635N     |
|COCH-ARM / FISHERS |     P=0.317N     P=0.218N     P=0.226N     P=0.218N    |P=0.399      P=0.253N     P=0.508N     P=0.691N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node                                                                                                                       |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/1 (0%)     0/1 (0%)    |4/6 (67%)    3/4 (75%)    2/5 (40%)    0/4 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |74.2%        75.3%        47.9%        0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/2 (0%)     0/0 (0%)     0/0 (0%)    |3/3 (100%)   2/2 (100%)   1/3 (33%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |596          600          637          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.033N*    P=0.755N     P=0.298N     P=0.059N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.014N*    P=0.755      P=0.437N     P=0.022N*    |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.016N*    P=0.708      P=0.433N     P=0.029N*    |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.014N*    P=0.745N     P=0.412N     P=0.015N*    |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.026N*    P=0.696      P=0.439N     P=0.057N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.031N*    P=0.667      P=0.392N     P=0.071N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/27 (0%)    0/22 (0%)    2/27 (7%)    0/28 (0%)   |1/33 (3%)    1/27 (4%)    1/30 (3%)    2/37 (5%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         8.9%         0.0%        |3.2%         4.4%         3.9%         5.8%         |
|TERMINAL (d)       |     0/19 (0%)    0/16 (0%)    1/16 (6%)    0/19 (0%)   |1/26 (4%)    1/18 (6%)    1/19 (5%)    1/29 (3%)    |
|FIRST INCIDENCE    |     ---          ---          548          ---         |734 (T)      734 (T)      734 (T)      713          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.628N     (e)          P=0.211      (e)         |P=0.472      P=0.678      P=0.691      P=0.544      |
|POLY 3             |     P=0.611N     (e)          P=0.227      (e)         |P=0.464      P=0.691      P=0.719      P=0.539      |
|POLY 1.5           |     P=0.615N     (e)          P=0.231      (e)         |P=0.460      P=0.698      P=0.728      P=0.540      |
|POLY 6             |     P=0.610N     (e)          P=0.220      (e)         |P=0.467      P=0.685      P=0.708      P=0.538      |
|LOGISTIC REGRESSION|     P=0.656N     (e)          P=0.243      (e)         |P=0.471      P=0.678      P=0.691      P=0.536      |
|COCH-ARM / FISHERS |     P=0.624N     (e)          P=0.245      (e)         |P=0.448      P=0.702      P=0.730      P=0.543      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/28 (0%)    0/33 (0%)    0/23 (0%)    1/28 (4%)   |1/36 (3%)    2/40 (5%)    0/43 (0%)    2/40 (5%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         3.7%        |3.1%         5.7%         0.0%         5.4%         |
|TERMINAL (d)       |     0/22 (0%)    0/23 (0%)    0/14 (0%)    0/25 (0%)   |1/26 (4%)    1/28 (4%)    0/27 (0%)    2/31 (7%)    |
|FIRST INCIDENCE    |     ---          ---          ---          707         |734 (T)      600          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.256      (e)          (e)          P=0.526     |P=0.502      P=0.520      P=0.492N     P=0.562      |
|POLY 3             |     P=0.237      (e)          (e)          P=0.510     |P=0.479      P=0.524      P=0.476N     P=0.543      |
|POLY 1.5           |     P=0.231      (e)          (e)          P=0.506     |P=0.474      P=0.525      P=0.472N     P=0.540      |
|POLY 6             |     P=0.243      (e)          (e)          P=0.515     |P=0.485      P=0.530      P=0.481N     P=0.548      |
|LOGISTIC REGRESSION|     P=0.232      (e)          (e)          P=0.493     |P=0.476      P=0.543      (e)          P=0.562      |
|COCH-ARM / FISHERS |     P=0.223      (e)          (e)          P=0.500     |P=0.466      P=0.540      P=0.456N     P=0.540      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/40 (5%)    0/39 (0%)    1/38 (3%)    1/31 (3%)   |4/41 (10%)   1/34 (3%)    3/40 (8%)    2/40 (5%)    |
|POLY-3 ADJUSTED (b)|     5.8%         0.0%         3.1%         3.3%        |10.7%        3.4%         8.2%         5.2%         |
|TERMINAL (d)       |     1/27 (4%)    0/30 (0%)    1/27 (4%)    0/26 (0%)   |3/30 (10%)   0/23 (0%)    0/27 (0%)    2/35 (6%)    |
|FIRST INCIDENCE    |     692          ---          733 (T)      637         |547          646          411          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.643N     P=0.228N     P=0.524N     P=0.482N    |P=0.381N     P=0.239N     P=0.522N     P=0.277N     |
|POLY 3             |     P=0.676      P=0.233N     P=0.521N     P=0.547N    |P=0.397N     P=0.256N     P=0.514N     P=0.321N     |
|POLY 1.5           |     P=0.665      P=0.236N     P=0.521N     P=0.563N    |P=0.416N     P=0.251N     P=0.514N     P=0.333N     |
|POLY 6             |     P=0.688      P=0.229N     P=0.523N     P=0.529N    |P=0.377N     P=0.260N     P=0.514N     P=0.306N     |
|LOGISTIC REGRESSION|     P=0.652      P=0.233N     P=0.520N     P=0.634N    |P=0.608      P=0.213N     P=0.315N     P=0.398N     |
|COCH-ARM / FISHERS |     P=0.649      P=0.253N     P=0.519N     P=0.596N    |P=0.443N     P=0.243N     P=0.514N     P=0.350N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/46 (2%)    2/46 (4%)    0/47 (0%)   |0/48 (0%)    1/47 (2%)    0/47 (0%)    2/46 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.5%         5.4%         0.0%        |0.0%         2.4%         0.0%         4.6%         |
|TERMINAL (d)       |     0/34 (0%)    1/34 (3%)    1/29 (3%)    0/36 (0%)   |0/33 (0%)    1/32 (3%)    0/31 (0%)    2/37 (5%)    |
|FIRST INCIDENCE    |     ---          733 (T)      630          ---         |---          734 (T)      ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.448N     P=0.500      P=0.211      (e)         |P=0.186      P=0.494      (e)          P=0.264      |
|POLY 3             |     P=0.453N     P=0.487      P=0.206      (e)         |P=0.160      P=0.498      (e)          P=0.247      |
|POLY 1.5           |     P=0.463N     P=0.485      P=0.210      (e)         |P=0.155      P=0.496      (e)          P=0.240      |
|POLY 6             |     P=0.442N     P=0.489      P=0.202      (e)         |P=0.167      P=0.502      (e)          P=0.255      |
|LOGISTIC REGRESSION|     P=0.470N     P=0.500      P=0.216      (e)         |(e)          P=0.494      (e)          P=0.264      |
|COCH-ARM / FISHERS |     P=0.479N     P=0.479      P=0.227      (e)         |P=0.145      P=0.495      (e)          P=0.237      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/46 (4%)    0/46 (0%)    3/47 (6%)   |0/48 (0%)    2/47 (4%)    1/47 (2%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         5.0%         0.0%         6.9%        |0.0%         4.9%         2.4%         2.3%         |
|TERMINAL (d)       |     1/34 (3%)    2/34 (6%)    0/29 (0%)    3/36 (8%)   |0/33 (0%)    2/32 (6%)    0/31 (0%)    1/37 (3%)    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      ---          733 (T)     |---          734 (T)      637          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.238      P=0.500      P=0.532N     P=0.325     |P=0.666N     P=0.231      P=0.510      P=0.523      |
|POLY 3             |     P=0.226      P=0.477      P=0.531N     P=0.309     |P=0.676      P=0.235      P=0.499      P=0.509      |
|POLY 1.5           |     P=0.217      P=0.474      P=0.526N     P=0.299     |P=0.664      P=0.233      P=0.498      P=0.502      |
|POLY 6             |     P=0.237      P=0.480      P=0.535N     P=0.320     |P=0.685N     P=0.239      P=0.499      P=0.516      |
|LOGISTIC REGRESSION|     P=0.238      P=0.500      (e)          P=0.325     |P=0.662      P=0.231      P=0.491      P=0.523      |
|COCH-ARM / FISHERS |     P=0.202      P=0.468      P=0.521N     P=0.285     |P=0.645      P=0.242      P=0.495      P=0.489      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/2 (0%)     0/2 (0%)     0/0 (0%)    |0/50 (0%)    2/49 (4%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.7%         2.4%         4.3%         |
|TERMINAL (d)       |     0/1 (0%)     0/2 (0%)     0/0 (0%)     0/0 (0%)    |0/34 (0%)    1/33 (3%)    1/32 (3%)    1/40 (3%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          721          734 (T)      713          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.410      P=0.243      P=0.488      P=0.276      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.378      P=0.232      P=0.496      P=0.255      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.366      P=0.231      P=0.496      P=0.248      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.391      P=0.235      P=0.494      P=0.263      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.393      P=0.237      P=0.488      P=0.260      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.346      P=0.242      P=0.495      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/7 (100%)   4/4 (100%)   6/7 (86%)    3/3 (100%)  |13/15 (87%)  6/6 (100%)   8/11 (73%)   7/10 (70%)   |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       85.7%        100.0%      |87.2%        100.0%       75.0%        74.4%        |
|TERMINAL (d)       |     5/5 (100%)   2/2 (100%)   4/5 (80%)    3/3 (100%)  |12/13 (92%)  5/5 (100%)   6/8 (75%)    4/5 (80%)    |
|FIRST INCIDENCE    |     385          665          630          733 (T)     |566          497          621          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.166N     (e)          P=0.544N     (e)         |P=0.448      P=0.594      P=0.550N     P=0.527      |
|POLY 3             |     P=0.859N     (e)          P=0.500N     (e)         |P=0.262N     P=0.468      P=0.395N     P=0.396N     |
|POLY 1.5           |     P=0.859N     (e)          P=0.500N     (e)         |P=0.229N     P=0.461      P=0.376N     P=0.354N     |
|POLY 6             |     P=0.859N     (e)          P=0.500N     (e)         |P=0.321N     P=0.481      P=0.426N     P=0.467N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.215N     P=0.469      P=0.363N     P=0.363N     |
|COCH-ARM / FISHERS |     P=0.871N     (e)          P=0.500N     (e)         |P=0.193N     P=0.500      P=0.346N     P=0.301N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   11/49 (22%)  27/49 (55%)  28/50 (56%) |5/50 (10%)   12/48 (25%)  25/49 (51%)  42/50 (84%)  |
|POLY-3 ADJUSTED (b)|     16.0%        25.0%        64.9%        59.0%       |11.1%        28.0%        56.9%        85.3%        |
|TERMINAL (d)       |     5/34 (15%)   8/36 (22%)   21/30 (70%)  23/38 (61%) |2/34 (6%)    9/33 (27%)   22/32 (69%)  35/40 (88%)  |
|FIRST INCIDENCE    |     547          574          287          413         |448          497          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.265      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.055      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.216      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.040 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.210      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.040 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.226      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.041 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.207      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.045 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.204      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.044 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Glands                                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    10/49 (20%)  48/49 (98%)  46/50 (92%) |0/50 (0%)    33/48 (69%)  46/49 (94%)  47/50 (94%)  |
|POLY-3 ADJUSTED (b)|     0.0%         22.9%        99.4%        92.9%       |0.0%         75.3%        96.3%        95.0%        |
|TERMINAL (d)       |     0/34 (0%)    7/36 (19%)   30/30 (100%) 35/38 (92%) |0/34 (0%)    29/33 (88%)  31/32 (97%)  38/40 (95%)  |
|FIRST INCIDENCE    |     ---          574          287          382         |---          457          413          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Glands                                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    6/49 (12%)   35/49 (71%)  47/50 (94%) |1/50 (2%)    1/48 (2%)    34/49 (69%)  46/50 (92%)  |
|POLY-3 ADJUSTED (b)|     0.0%         13.6%        79.5%        94.1%       |2.3%         2.4%         70.6%        93.1%        |
|TERMINAL (d)       |     0/34 (0%)    4/36 (11%)   25/30 (83%)  36/38 (95%) |1/34 (3%)    1/33 (3%)    20/32 (63%)  38/40 (95%)  |
|FIRST INCIDENCE    |     ---          287          287          382         |734 (T)      734 (T)      411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.022 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.755      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.754      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.752      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.017 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.758      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.755      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.742      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Lateral Wall                                                                                                               |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    9/49 (18%)   10/49 (20%)  20/50 (40%) |3/50 (6%)    14/48 (29%)  16/49 (33%)  36/50 (72%)  |
|POLY-3 ADJUSTED (b)|     0.0%         19.6%        24.2%        42.4%       |6.8%         30.9%        34.0%        72.9%        |
|TERMINAL (d)       |     0/34 (0%)    4/36 (11%)   5/30 (17%)   16/38 (42%) |1/34 (3%)    5/33 (15%)   6/32 (19%)   28/40 (70%)  |
|FIRST INCIDENCE    |     ---          287          471          582         |448          457          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.006 **   P=0.002 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Lateral Wall                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    3/49 (6%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    4/49 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.6%         0.0%        |0.0%         0.0%         9.2%         2.1%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    2/30 (7%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    2/32 (6%)    1/40 (3%)    |
|FIRST INCIDENCE    |     ---          ---          548          ---         |---          ---          469          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.551N     (e)          P=0.103      (e)         |P=0.563      (e)          P=0.063      P=0.532      |
|POLY 3             |     P=0.559N     (e)          P=0.103      (e)         |P=0.559      (e)          P=0.060      P=0.515      |
|POLY 1.5           |     P=0.567N     (e)          P=0.107      (e)         |P=0.544      (e)          P=0.059      P=0.510      |
|POLY 6             |     P=0.550N     (e)          P=0.100      (e)         |P=0.573      (e)          P=0.060      P=0.521      |
|LOGISTIC REGRESSION|     P=0.589N     (e)          P=0.117      (e)         |P=0.468      (e)          P=0.058      P=0.532      |
|COCH-ARM / FISHERS |     P=0.578N     (e)          P=0.117      (e)         |P=0.514      (e)          P=0.056      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    15/49 (31%)  49/49 (100%) 50/50 (100%)|2/50 (4%)    35/48 (73%)  49/49 (100%) 50/50 (100%) |
|POLY-3 ADJUSTED (b)|     6.8%         33.6%        100.0%       100.0%      |4.6%         78.1%        100.0%       100.0%       |
|TERMINAL (d)       |     1/34 (3%)    10/36 (28%)  30/30 (100%) 38/38 (100%)|1/34 (3%)    28/33 (85%)  32/32 (100%) 40/40 (100%) |
|FIRST INCIDENCE    |     547          574          287          382         |547          441          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    21/49 (43%)  39/50 (78%) |7/50 (14%)   14/48 (29%)  28/49 (57%)  45/50 (90%)  |
|POLY-3 ADJUSTED (b)|     4.5%         6.9%         50.4%        81.7%       |16.2%        32.1%        59.0%        90.2%        |
|TERMINAL (d)       |     0/34 (0%)    2/36 (6%)    15/30 (50%)  32/38 (84%) |7/34 (21%)   10/33 (30%)  15/32 (47%)  36/40 (90%)  |
|FIRST INCIDENCE    |     567          632          471          413         |734 (T)      457          413          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.512      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.063      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.490      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.067      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.490      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.060      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.491      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.080      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.490      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.058      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.490      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.056      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    12/49 (24%)  49/49 (100%) 50/50 (100%)|0/50 (0%)    31/48 (65%)  49/49 (100%) 49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     0.0%         27.2%        100.0%       100.0%      |0.0%         71.0%        100.0%       98.0%        |
|TERMINAL (d)       |     0/34 (0%)    8/36 (22%)   30/30 (100%) 38/38 (100%)|0/34 (0%)    27/33 (82%)  32/32 (100%) 39/40 (98%)  |
|FIRST INCIDENCE    |     ---          574          287          382         |---          457          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   18/49 (37%)  42/49 (86%)  45/50 (90%) |19/50 (38%)  44/48 (92%)  49/49 (100%) 48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     11.5%        41.2%        89.7%        92.5%       |42.3%        94.5%        100.0%       96.0%        |
|TERMINAL (d)       |     4/34 (12%)   15/36 (42%)  27/30 (90%)  35/38 (92%) |14/34 (41%)  31/33 (94%)  32/32 (100%) 38/40 (95%)  |
|FIRST INCIDENCE    |     651          582          287          413         |547          261          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P=0.046 *    P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    10/49 (20%)  20/50 (40%) |1/50 (2%)    9/48 (19%)   21/49 (43%)  39/50 (78%)  |
|POLY-3 ADJUSTED (b)|     0.0%         4.6%         24.6%        42.3%       |2.3%         20.7%        45.5%        79.7%        |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    6/30 (20%)   17/38 (45%) |0/34 (0%)    4/33 (12%)   12/32 (38%)  32/40 (80%)  |
|FIRST INCIDENCE    |     ---          433          471          582         |651          600          411          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.244      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.240      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.237      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.242      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.241      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.242      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/48 (0%)    2/49 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         0.0%         2.2%        |0.0%         0.0%         4.7%         6.4%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    1/32 (3%)    3/40 (8%)    |
|FIRST INCIDENCE    |     721          ---          ---          733 (T)     |---          ---          665          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.547      P=0.494N     P=0.531N     P=0.736N    |P=0.074      (e)          P=0.236      P=0.151      |
|POLY 3             |     P=0.538      P=0.502N     P=0.520N     P=0.747N    |P=0.057      (e)          P=0.233      P=0.133      |
|POLY 1.5           |     P=0.533      P=0.503N     P=0.514N     P=0.753N    |P=0.054      (e)          P=0.233      P=0.128      |
|POLY 6             |     P=0.544      P=0.500N     P=0.526N     P=0.741N    |P=0.060      (e)          P=0.233      P=0.139      |
|LOGISTIC REGRESSION|     P=0.549      P=0.500N     P=0.526N     P=0.741N    |P=0.061      (e)          P=0.233      P=0.151      |
|COCH-ARM / FISHERS |     P=0.525      P=0.505N     P=0.505N     P=0.753N    |P=0.048 *    (e)          P=0.242      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    13/49 (27%)  21/50 (42%) |0/50 (0%)    0/48 (0%)    9/49 (18%)   13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         32.7%        43.4%       |0.0%         0.0%         20.9%        27.1%        |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    10/30 (33%)  14/38 (37%) |0/34 (0%)    0/33 (0%)    6/32 (19%)   9/40 (23%)   |
|FIRST INCIDENCE    |     ---          733 (T)      651          382         |---          ---          637          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.511      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.003 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.499      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.497      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.500      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.511      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.002 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.495      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    2/49 (4%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         4.7%         2.4%         0.0%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    1/33 (3%)    0/31 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |                                                        |---          649          698          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.331N     P=0.236      P=0.483      (e)          |
|POLY 3             |                                                        |P=0.344N     P=0.233      P=0.491      (e)          |
|POLY 1.5           |                                                        |P=0.354N     P=0.232      P=0.492      (e)          |
|POLY 6             |                                                        |P=0.332N     P=0.237      P=0.490      (e)          |
|LOGISTIC REGRESSION|                                                        |P=0.369N     P=0.233      P=0.492      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.368N     P=0.242      P=0.490      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/50 (8%)    3/49 (6%)    1/48 (2%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |9.3%         7.1%         2.4%         4.3%         |
|TERMINAL (d)       |                                                        |4/34 (12%)   3/33 (9%)    0/31 (0%)    2/40 (5%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      734 (T)      639          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.271N     P=0.517N     P=0.204N     P=0.264N     |
|POLY 3             |                                                        |P=0.319N     P=0.513N     P=0.190N     P=0.307N     |
|POLY 1.5           |                                                        |P=0.332N     P=0.515N     P=0.190N     P=0.322N     |
|POLY 6             |                                                        |P=0.305N     P=0.506N     P=0.190N     P=0.291N     |
|LOGISTIC REGRESSION|                                                        |P=0.296N     P=0.517N     P=0.194N     P=0.264N     |
|COCH-ARM / FISHERS |                                                        |P=0.355N     P=0.511N     P=0.194N     P=0.349N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |14/50 (28%)  14/49 (29%)  18/48 (38%)  15/49 (31%)  |
|POLY-3 ADJUSTED (b)|                                                        |31.3%        32.4%        41.9%        31.9%        |
|TERMINAL (d)       |                                                        |10/34 (29%)  11/33 (33%)  15/31 (48%)  11/40 (28%)  |
|FIRST INCIDENCE    |                                                        |448          457          413          609          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.351N     P=0.557      P=0.193      P=0.486N     |
|POLY 3             |                                                        |P=0.496N     P=0.545      P=0.204      P=0.565      |
|POLY 1.5           |                                                        |P=0.544N     P=0.546      P=0.211      P=0.530      |
|POLY 6             |                                                        |P=0.440N     P=0.550      P=0.189      P=0.573N     |
|LOGISTIC REGRESSION|                                                        |P=0.547N     P=0.557      P=0.213      P=0.505      |
|COCH-ARM / FISHERS |                                                        |P=0.490      P=0.563      P=0.216      P=0.474      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary: Interstitial Cell                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    2/49 (4%)    1/48 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         4.7%         2.4%         0.0%         |
|TERMINAL (d)       |                                                        |1/34 (3%)    1/33 (3%)    1/31 (3%)    0/40 (0%)    |
|FIRST INCIDENCE    |                                                        |734 (T)      649          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.205N     P=0.493      P=0.741      P=0.468N     |
|POLY 3             |                                                        |P=0.220N     P=0.494      P=0.751      P=0.487N     |
|POLY 1.5           |                                                        |P=0.228N     P=0.492      P=0.751      P=0.493N     |
|POLY 6             |                                                        |P=0.211N     P=0.501      P=0.749      P=0.480N     |
|LOGISTIC REGRESSION|                                                        |P=0.223N     P=0.491      P=0.741      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.240N     P=0.492      P=0.742      P=0.505N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/49 (6%)    4/48 (8%)    10/49 (20%) |7/50 (14%)   3/48 (6%)    5/49 (10%)   9/49 (18%)   |
|POLY-3 ADJUSTED (b)|     16.2%        7.0%         10.2%        21.9%       |16.2%        7.1%         11.7%        19.3%        |
|TERMINAL (d)       |     6/34 (18%)   3/36 (8%)    3/30 (10%)   8/38 (21%)  |7/34 (21%)   2/33 (6%)    4/32 (13%)   8/40 (20%)   |
|FIRST INCIDENCE    |     721          733 (T)      471          413         |734 (T)      601          621          609          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091      P=0.137N     P=0.335N     P=0.387     |P=0.220      P=0.168N     P=0.412N     P=0.530      |
|POLY 3             |     P=0.070      P=0.159N     P=0.315N     P=0.343     |P=0.152      P=0.163N     P=0.387N     P=0.457      |
|POLY 1.5           |     P=0.062      P=0.163N     P=0.305N     P=0.318     |P=0.138      P=0.170N     P=0.389N     P=0.425      |
|POLY 6             |     P=0.080      P=0.155N     P=0.325N     P=0.371     |P=0.167      P=0.152N     P=0.387N     P=0.493      |
|LOGISTIC REGRESSION|     P=0.066      P=0.143N     P=0.325N     P=0.315     |P=0.164      P=0.163N     P=0.405N     P=0.487      |
|COCH-ARM / FISHERS |     P=0.053      P=0.167N     P=0.286N     P=0.282     |P=0.115      P=0.176N     P=0.394N     P=0.376      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    2/48 (4%)    0/49 (0%)   |1/50 (2%)    0/48 (0%)    2/49 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         5.2%         0.0%        |2.3%         0.0%         4.7%         2.2%         |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    2/30 (7%)    0/38 (0%)   |1/34 (3%)    0/33 (0%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     733 (T)      ---          733 (T)      ---         |734 (T)      ---          632          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.409N     P=0.489N     P=0.456      P=0.478N    |P=0.637      P=0.506N     P=0.498      P=0.725N     |
|POLY 3             |     P=0.422N     P=0.501N     P=0.461      P=0.492N    |P=0.627      P=0.506N     P=0.497      P=0.746N     |
|POLY 1.5           |     P=0.429N     P=0.503N     P=0.470      P=0.497N    |P=0.615      P=0.508N     P=0.496      P=0.753N     |
|POLY 6             |     P=0.414N     P=0.500N     P=0.453      P=0.487N    |P=0.638      P=0.502N     P=0.499      P=0.737N     |
|LOGISTIC REGRESSION|     P=0.409N     (e)          P=0.456      (e)         |P=0.587      (e)          P=0.492      P=0.725N     |
|COCH-ARM / FISHERS |     P=0.439N     P=0.505N     P=0.485      P=0.505N    |P=0.593      P=0.510N     P=0.492      P=0.747      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/48 (8%)    1/48 (2%)    2/49 (4%)   |15/48 (31%)  17/48 (35%)  15/48 (31%)  17/49 (35%)  |
|POLY-3 ADJUSTED (b)|     7.0%         9.6%         2.6%         4.5%        |35.7%        40.8%        35.2%        36.4%        |
|TERMINAL (d)       |     3/34 (9%)    4/35 (11%)   1/29 (3%)    2/37 (5%)   |14/33 (42%)  14/33 (42%)  12/32 (38%)  14/40 (35%)  |
|FIRST INCIDENCE    |     733 (T)      733 (T)      733 (T)      733 (T)     |651          684          637          665          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.327N     P=0.516      P=0.363N     P=0.461N    |P=0.367N     P=0.413      P=0.557      P=0.504N     |
|POLY 3             |     P=0.336N     P=0.484      P=0.352N     P=0.483N    |P=0.505N     P=0.396      P=0.572N     P=0.559      |
|POLY 1.5           |     P=0.350N     P=0.480      P=0.340N     P=0.494N    |P=0.557N     P=0.396      P=0.578N     P=0.514      |
|POLY 6             |     P=0.320N     P=0.487      P=0.364N     P=0.470N    |P=0.449N     P=0.411      P=0.567N     P=0.567N     |
|LOGISTIC REGRESSION|     P=0.327N     P=0.516      P=0.363N     P=0.461N    |P=0.442N     P=0.435      P=0.581      P=0.561N     |
|COCH-ARM / FISHERS |     P=0.371N     P=0.477      P=0.324N     P=0.510N    |P=0.467      P=0.414      P=0.587N     P=0.443      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/49 (6%)    2/49 (4%)    6/50 (12%)  |                                                    |
|POLY-3 ADJUSTED (b)|     7.0%         7.0%         5.1%         12.9%       |                                                    |
|TERMINAL (d)       |     3/34 (9%)    3/36 (8%)    1/30 (3%)    2/38 (5%)   |                                                    |
|FIRST INCIDENCE    |     733 (T)      733 (T)      665          637         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.174      P=0.637N     P=0.555N     P=0.313     |                                                    |
|POLY 3             |     P=0.147      P=0.660      P=0.543N     P=0.279     |                                                    |
|POLY 1.5           |     P=0.136      P=0.656      P=0.531N     P=0.263     |                                                    |
|POLY 6             |     P=0.163      P=0.662N     P=0.554N     P=0.301     |                                                    |
|LOGISTIC REGRESSION|     P=0.152      P=0.637N     P=0.559N     P=0.268     |                                                    |
|COCH-ARM / FISHERS |     P=0.120      P=0.651      P=0.510N     P=0.243     |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/49 (0%)    1/49 (2%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     7.0%         0.0%         2.6%         4.4%        |                                                    |
|TERMINAL (d)       |     2/34 (6%)    0/36 (0%)    0/30 (0%)    1/38 (3%)   |                                                    |
|FIRST INCIDENCE    |     721          ---          665          707         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.586      P=0.115N     P=0.354N     P=0.444N    |                                                    |
|POLY 3             |     P=0.567      P=0.120N     P=0.340N     P=0.472N    |                                                    |
|POLY 1.5           |     P=0.558      P=0.121N     P=0.330N     P=0.484N    |                                                    |
|POLY 6             |     P=0.578      P=0.118N     P=0.349N     P=0.459N    |                                                    |
|LOGISTIC REGRESSION|     P=0.572      P=0.118N     P=0.345N     P=0.457N    |                                                    |
|COCH-ARM / FISHERS |     P=0.543      P=0.125N     P=0.316N     P=0.500N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/48 (0%)    0/49 (0%)   |1/50 (2%)    0/49 (0%)    1/49 (2%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     4.6%         2.3%         0.0%         0.0%        |2.3%         0.0%         2.4%         2.1%         |
|TERMINAL (d)       |     1/34 (3%)    1/36 (3%)    0/29 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     721          733 (T)      ---          ---         |693          ---          665          574          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199N     P=0.484N     P=0.275N     P=0.216N    |P=0.600      P=0.505N     P=0.757      P=0.732N     |
|POLY 3             |     P=0.200N     P=0.502N     P=0.266N     P=0.227N    |P=0.596      P=0.505N     P=0.756      P=0.742N     |
|POLY 1.5           |     P=0.206N     P=0.503N     P=0.259N     P=0.233N    |P=0.586      P=0.506N     P=0.756      P=0.749N     |
|POLY 6             |     P=0.193N     P=0.500N     P=0.274N     P=0.220N    |P=0.605      P=0.504N     P=0.755      P=0.734N     |
|LOGISTIC REGRESSION|     P=0.195N     P=0.496N     P=0.277N     P=0.216N    |P=0.504      P=0.505N     P=0.758      P=0.684      |
|COCH-ARM / FISHERS |     P=0.216N     P=0.500N     P=0.258N     P=0.253N    |P=0.566      P=0.505N     P=0.747      P=0.753N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Prepuce                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/48 (6%)    2/49 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         4.6%         7.7%         4.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    1/36 (3%)    1/29 (3%)    1/38 (3%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     537          287          582          716         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.551N     P=0.690      P=0.441      P=0.662N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.576N     P=0.692      P=0.442      P=0.683N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.589N     P=0.692      P=0.456      P=0.690N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.562N     P=0.692      P=0.429      P=0.675N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.579      P=0.620N     P=0.537      P=0.655     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.608N     P=0.691N     P=0.480      P=0.684     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/48 (2%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.6%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    1/29 (3%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          590          733 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.343N     P=0.242      P=0.468      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.346N     P=0.240      P=0.475      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.357N     P=0.237      P=0.481      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.334N     P=0.244      P=0.468      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.383N     P=0.251      P=0.468      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.371N     P=0.247      P=0.490      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   12/49 (24%)  11/49 (22%)  9/50 (18%)  |11/50 (22%)  11/48 (23%)  12/49 (24%)  17/49 (35%)  |
|POLY-3 ADJUSTED (b)|     15.2%        26.0%        26.5%        18.9%       |24.7%        24.8%        26.0%        35.9%        |
|TERMINAL (d)       |     1/34 (3%)    5/36 (14%)   3/30 (10%)   4/38 (11%)  |6/34 (18%)   6/33 (18%)   3/32 (9%)    13/40 (33%)  |
|FIRST INCIDENCE    |     465          287          497          413         |566          457          411          582          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.407N     P=0.188      P=0.161      P=0.471     |P=0.208      P=0.566      P=0.473      P=0.271      |
|POLY 3             |     P=0.456N     P=0.154      P=0.150      P=0.423     |P=0.102      P=0.590      P=0.537      P=0.172      |
|POLY 1.5           |     P=0.474N     P=0.149      P=0.166      P=0.411     |P=0.090      P=0.572      P=0.516      P=0.151      |
|POLY 6             |     P=0.437N     P=0.161      P=0.142      P=0.439     |P=0.113      P=0.583N     P=0.554      P=0.196      |
|LOGISTIC REGRESSION|     P=0.529      P=0.110      P=0.264      P=0.266     |P=0.037 *    P=0.554      P=0.474      P=0.131      |
|COCH-ARM / FISHERS |     P=0.502N     P=0.142      P=0.204      P=0.393     |P=0.071      P=0.553      P=0.478      P=0.119      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)   |8/50 (16%)   8/48 (17%)   4/49 (8%)    5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     0.0%         4.7%         0.0%         0.0%        |18.5%        18.9%        9.5%         10.8%        |
|TERMINAL (d)       |     0/34 (0%)    2/36 (6%)    0/30 (0%)    0/38 (0%)   |7/34 (21%)   7/33 (21%)   4/32 (13%)   5/40 (13%)   |
|FIRST INCIDENCE    |     ---          733 (T)      ---          ---         |715          600          734 (T)      734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.371N     P=0.251      (e)          (e)         |P=0.137N     P=0.589      P=0.207N     P=0.181N     |
|POLY 3             |     P=0.368N     P=0.235      (e)          (e)         |P=0.189N     P=0.592      P=0.186N     P=0.234N     |
|POLY 1.5           |     P=0.376N     P=0.234      (e)          (e)         |P=0.207N     P=0.580      P=0.186N     P=0.255N     |
|POLY 6             |     P=0.358N     P=0.237      (e)          (e)         |P=0.171N     P=0.608N     P=0.189N     P=0.213N     |
|LOGISTIC REGRESSION|     (e)          P=0.251      (e)          (e)         |P=0.159N     P=0.602      P=0.207N     P=0.186N     |
|COCH-ARM / FISHERS |     P=0.388N     P=0.242      (e)          (e)         |P=0.239N     P=0.572      P=0.188N     P=0.290N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/48 (4%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.3%         0.0%         2.2%        |0.0%         4.8%         2.3%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    1/38 (3%)   |0/34 (0%)    1/33 (3%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     ---          497          ---          733 (T)     |---          721          632          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.494      P=0.500      (e)          P=0.522     |P=0.332N     P=0.243      P=0.514      (e)          |
|POLY 3             |     P=0.498      P=0.502      (e)          P=0.512     |P=0.342N     P=0.231      P=0.497      (e)          |
|POLY 1.5           |     P=0.491      P=0.499      (e)          P=0.507     |P=0.352N     P=0.229      P=0.497      (e)          |
|POLY 6             |     P=0.507      P=0.505      (e)          P=0.518     |P=0.330N     P=0.235      P=0.497      (e)          |
|LOGISTIC REGRESSION|     P=0.446      P=0.547      (e)          P=0.522     |P=0.367N     P=0.236      P=0.493      (e)          |
|COCH-ARM / FISHERS |     P=0.480      P=0.495      (e)          P=0.500     |P=0.367N     P=0.237      P=0.495      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    3/48 (6%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.5%         0.0%        |0.0%         7.0%         0.0%         2.2%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    1/33 (3%)    0/32 (0%)    1/40 (3%)    |
|FIRST INCIDENCE    |     ---          ---          502          ---         |---          441          ---          734 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.760N     (e)          P=0.482      (e)         |P=0.573N     P=0.121      (e)          P=0.532      |
|POLY 3             |     P=0.762N     (e)          P=0.484      (e)         |P=0.598N     P=0.116      (e)          P=0.513      |
|POLY 1.5           |     P=0.766N     (e)          P=0.489      (e)         |P=0.610N     P=0.114      (e)          P=0.507      |
|POLY 6             |     P=0.758N     (e)          P=0.479      (e)         |P=0.583N     P=0.120      (e)          P=0.520      |
|LOGISTIC REGRESSION|     P=0.849N     (e)          P=0.631      (e)         |P=0.687N     P=0.118      (e)          P=0.532      |
|COCH-ARM / FISHERS |     P=0.771N     (e)          P=0.500      (e)         |P=0.625N     P=0.114      (e)          P=0.495      |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   2/50 (4%)    5/50 (10%)  |2/50 (4%)    8/48 (17%)   6/49 (12%)   3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     4.6%         11.4%        5.0%         10.9%       |4.5%         18.6%        13.6%        6.5%         |
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    1/30 (3%)    5/38 (13%)  |0/34 (0%)    5/33 (15%)   2/32 (6%)    2/40 (5%)    |
|FIRST INCIDENCE    |     484          497          502          733 (T)     |352          441          413          689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.338      P=0.238      P=0.654      P=0.258     |P=0.230N     P=0.049 *    P=0.143      P=0.544      |
|POLY 3             |     P=0.313      P=0.217      P=0.658      P=0.234     |P=0.261N     P=0.038 *    P=0.128      P=0.517      |
|POLY 1.5           |     P=0.301      P=0.213      P=0.670      P=0.227     |P=0.277N     P=0.038 *    P=0.128      P=0.506      |
|POLY 6             |     P=0.327      P=0.223      P=0.648      P=0.243     |P=0.242N     P=0.040 *    P=0.129      P=0.530      |
|LOGISTIC REGRESSION|     P=0.264      P=0.206      P=0.632N     P=0.216     |P=0.446N     P=0.042 *    P=0.102      P=0.211      |
|COCH-ARM / FISHERS |     P=0.283      P=0.210      P=0.691N     P=0.218     |P=0.303N     P=0.039 *    P=0.128      P=0.490      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/48 (0%)    2/47 (4%)    2/48 (4%)   |0/50 (0%)    2/46 (4%)    2/49 (4%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         5.2%         4.5%        |0.0%         5.0%         4.7%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    2/30 (7%)    2/38 (5%)   |0/34 (0%)    2/33 (6%)    2/32 (6%)    0/40 (0%)    |
|FIRST INCIDENCE    |     567          ---          733 (T)      733 (T)     |---          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.331      P=0.491N     P=0.457      P=0.536     |P=0.296N     P=0.232      P=0.225      (e)          |
|POLY 3             |     P=0.306      P=0.508N     P=0.456      P=0.504     |P=0.313N     P=0.221      P=0.232      (e)          |
|POLY 1.5           |     P=0.298      P=0.508N     P=0.464      P=0.496     |P=0.326N     P=0.219      P=0.233      (e)          |
|POLY 6             |     P=0.316      P=0.508N     P=0.446      P=0.513     |P=0.298N     P=0.225      P=0.230      (e)          |
|LOGISTIC REGRESSION|     P=0.295      P=0.488N     P=0.479      P=0.469     |(e)          P=0.232      P=0.225      (e)          |
|COCH-ARM / FISHERS |     P=0.285      P=0.510N     P=0.477      P=0.485     |P=0.348N     P=0.227      P=0.242      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    1/47 (2%)    0/48 (0%)   |1/50 (2%)    0/46 (0%)    0/49 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         2.6%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     661          ---          471          ---         |715          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.283N     P=0.243N     P=0.541N     P=0.216N    |P=0.523N     P=0.494N     P=0.518N     P=0.473N     |
|POLY 3             |     P=0.291N     P=0.245N     P=0.537N     P=0.234N    |P=0.544N     P=0.515N     P=0.505N     P=0.489N     |
|POLY 1.5           |     P=0.297N     P=0.246N     P=0.531N     P=0.239N    |P=0.546N     P=0.517N     P=0.504N     P=0.497N     |
|POLY 6             |     P=0.285N     P=0.245N     P=0.544N     P=0.228N    |P=0.543N     P=0.512N     P=0.507N     P=0.482N     |
|LOGISTIC REGRESSION|     P=0.332N     P=0.247N     P=0.471N     P=0.255N    |P=0.533N     P=0.514N     P=0.505N     P=0.494N     |
|COCH-ARM / FISHERS |     P=0.305N     P=0.258N     P=0.523N     P=0.258N    |P=0.548N     P=0.521N     P=0.505N     P=0.510N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    5/49 (10%)   2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     9.1%         6.9%         12.6%        4.4%        |                                                    |
|TERMINAL (d)       |     1/34 (3%)    1/36 (3%)    3/30 (10%)   2/38 (5%)   |                                                    |
|FIRST INCIDENCE    |     567          598          582          733 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.247N     P=0.484N     P=0.420      P=0.291N    |                                                    |
|POLY 3             |     P=0.262N     P=0.501N     P=0.436      P=0.317N    |                                                    |
|POLY 1.5           |     P=0.273N     P=0.503N     P=0.454      P=0.325N    |                                                    |
|POLY 6             |     P=0.253N     P=0.496N     P=0.417      P=0.309N    |                                                    |
|LOGISTIC REGRESSION|     P=0.289N     P=0.490N     P=0.464      P=0.335N    |                                                    |
|COCH-ARM / FISHERS |     P=0.293N     P=0.500N     P=0.487      P=0.339N    |                                                    |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   9/49 (18%)   6/49 (12%)   13/48 (27%) |17/50 (34%)  21/49 (43%)  17/49 (35%)  30/49 (61%)  |
|POLY-3 ADJUSTED (b)|     18.1%        21.0%        15.4%        29.6%       |39.1%        49.3%        39.8%        64.6%        |
|TERMINAL (d)       |     5/34 (15%)   9/36 (25%)   6/30 (20%)   12/37 (32%) |15/34 (44%)  18/33 (55%)  15/32 (47%)  28/40 (70%)  |
|FIRST INCIDENCE    |     484          733 (T)      733 (T)      707         |693          681          637          689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.140      P=0.538      P=0.488N     P=0.226     |P=0.045 *    P=0.231      P=0.500      P=0.040 *    |
|POLY 3             |     P=0.095      P=0.470      P=0.488N     P=0.152     |P=0.007 **   P=0.229      P=0.564      P=0.010 *    |
|POLY 1.5           |     P=0.087      P=0.474      P=0.455N     P=0.146     |P=0.005 **   P=0.226      P=0.562      P=0.008 **   |
|POLY 6             |     P=0.105      P=0.463      P=0.523N     P=0.160     |P=0.010 *    P=0.246      P=0.561      P=0.014 *    |
|LOGISTIC REGRESSION|     P=0.122      P=0.493      P=0.462N     P=0.166     |P=0.020 *    P=0.255      P=0.515      P=0.024 *    |
|COCH-ARM / FISHERS |     P=0.077      P=0.482      P=0.403N     P=0.138     |P=0.004 **   P=0.242      P=0.555      P=0.006 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Trachea                                                                                                                          |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/48 (0%)    0/48 (0%)    0/49 (0%)   |0/50 (0%)    0/48 (0%)    1/49 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.3%         0.0%         |
|TERMINAL (d)       |     1/34 (3%)    0/36 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/33 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     597          ---          ---          ---         |---          ---          411          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.295N     P=0.233N     P=0.268N     P=0.220N    |P=0.768N     (e)          P=0.504      (e)          |
|POLY 3             |     P=0.296N     P=0.246N     P=0.265N     P=0.231N    |P=0.761N     (e)          P=0.499      (e)          |
|POLY 1.5           |     P=0.301N     P=0.246N     P=0.258N     P=0.235N    |P=0.766N     (e)          P=0.499      (e)          |
|POLY 6             |     P=0.292N     P=0.245N     P=0.272N     P=0.226N    |P=0.755N     (e)          P=0.499      (e)          |
|LOGISTIC REGRESSION|     P=0.314N     P=0.247N     P=0.239N     P=0.256N    |P=0.910      (e)          P=0.432      (e)          |
|COCH-ARM / FISHERS |     P=0.308N     P=0.258N     P=0.258N     P=0.253N    |P=0.776N     (e)          P=0.495      (e)          |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/47 (2%)    0/47 (0%)    0/50 (0%)   |0/49 (0%)    0/45 (0%)    0/49 (0%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         2.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/34 (0%)    0/35 (0%)    0/30 (0%)    0/38 (0%)   |0/34 (0%)    0/31 (0%)    0/32 (0%)    0/40 (0%)    |
|FIRST INCIDENCE    |     537          693          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.201N     P=0.503N     P=0.270N     P=0.230N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.196N     P=0.524N     P=0.271N     P=0.228N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.201N     P=0.524N     P=0.263N     P=0.232N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.191N     P=0.525N     P=0.279N     P=0.225N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.223N     P=0.514N     P=0.202N     P=0.271N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.208N     P=0.523N     P=0.263N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    0/49 (0%)    4/49 (8%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.8%         0.0%         9.5%         4.4%         |
|TERMINAL (d)       |                                                        |1/34 (3%)    0/33 (0%)    4/32 (13%)   1/39 (3%)    |
|FIRST INCIDENCE    |                                                        |547          ---          734 (T)      689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.564N     P=0.132N     P=0.482      P=0.451N     |
|POLY 3             |                                                        |P=0.605N     P=0.127N     P=0.475      P=0.484N     |
|POLY 1.5           |                                                        |P=0.619N     P=0.126N     P=0.482      P=0.493N     |
|POLY 6             |                                                        |P=0.594N     P=0.127N     P=0.464      P=0.475N     |
|LOGISTIC REGRESSION|                                                        |P=0.606      P=0.109N     P=0.489      P=0.613N     |
|COCH-ARM / FISHERS |                                                        |P=0.606      P=0.125N     P=0.489      P=0.510N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |5/50 (10%)   5/49 (10%)   4/49 (8%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |11.4%        11.8%        9.4%         6.5%         |
|TERMINAL (d)       |                                                        |3/34 (9%)    4/33 (12%)   3/32 (9%)    2/39 (5%)    |
|FIRST INCIDENCE    |                                                        |651          730          637          579          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.210N     P=0.612      P=0.525N     P=0.292N     |
|POLY 3             |                                                        |P=0.244N     P=0.607      P=0.517N     P=0.328N     |
|POLY 1.5           |                                                        |P=0.261N     P=0.608      P=0.514N     P=0.342N     |
|POLY 6             |                                                        |P=0.229N     P=0.609      P=0.526N     P=0.314N     |
|LOGISTIC REGRESSION|                                                        |P=0.259N     P=0.620      P=0.513N     P=0.389N     |
|COCH-ARM / FISHERS |                                                        |P=0.291N     P=0.617      P=0.513N     P=0.369N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |4/50 (8%)    3/49 (6%)    2/49 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |9.2%         7.1%         4.7%         0.0%         |
|TERMINAL (d)       |                                                        |3/34 (9%)    3/33 (9%)    2/32 (6%)    0/39 (0%)    |
|FIRST INCIDENCE    |                                                        |689          734 (T)      734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.039N*    P=0.518N     P=0.367N     P=0.049N*    |
|POLY 3             |                                                        |P=0.044N*    P=0.515N     P=0.349N     P=0.054N     |
|POLY 1.5           |                                                        |P=0.047N*    P=0.516N     P=0.347N     P=0.057N     |
|POLY 6             |                                                        |P=0.041N*    P=0.510N     P=0.354N     P=0.051N     |
|LOGISTIC REGRESSION|                                                        |P=0.042N*    P=0.501N     P=0.356N     P=0.052N     |
|COCH-ARM / FISHERS |                                                        |P=0.054N     P=0.511N     P=0.349N     P=0.061N     |
|=================================================================================================================================|
       Date:  04/25/97                           EXPERIMENT: 05201 TEST: 06                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -             FURFURYL ALCOHOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM    |CONTROL      2.0 PPM      8.0 PPM      32.0 PPM     |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    2/49 (4%)    1/49 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.3%         4.7%         2.4%         0.0%         |
|TERMINAL (d)       |                                                        |0/34 (0%)    1/33 (3%)    1/32 (3%)    0/39 (0%)    |
|FIRST INCIDENCE    |                                                        |693          600          734 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.211N     P=0.496      P=0.747      P=0.475N     |
|POLY 3             |                                                        |P=0.224N     P=0.494      P=0.755      P=0.490N     |
|POLY 1.5           |                                                        |P=0.230N     P=0.492      P=0.756      P=0.495N     |
|POLY 6             |                                                        |P=0.217N     P=0.500      P=0.753      P=0.484N     |
|LOGISTIC REGRESSION|                                                        |P=0.242N     P=0.496      P=0.757      P=0.514N     |
|COCH-ARM / FISHERS |                                                        |P=0.240N     P=0.492      P=0.747      P=0.505N     |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).