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TDMS Study 05203-08 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                              O-NITROTOLUENE                                             DATE: 11/16/00  
EXPERIMENT: 05203 TEST: 08                                                                                        TIME: 09:00:51    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62340D     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      O-NITROTOLUENE                                              DATE: 11/16/00    
EXPERIMENT: 05203 TEST: 08                                                                                        TIME:  9:28:19    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  62340D      
CONT: N01-ES-55393                                                                                                CAS: 88-72-2      
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                               CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                           
==================================================================================================================================  
           0 PPM                      625 PPM                            1250 PPM                           2000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4    18.1   238.8      18.4    237.1    1.02       48     18.5    234.7    1.02       99     17.9    228.0    0.99      157       
  8    17.5   303.3      17.0    299.4    0.97       36     16.8    294.8    0.96       71     16.1    281.5    0.92      114       
 12    17.3   343.7      17.0    336.6    0.98       32     17.1    326.5    0.99       65     16.5    314.7    0.95      105       
 16    17.3   369.9      16.8    362.6    0.97       29     16.7    349.8    0.97       60     16.3    329.4    0.94       99       
 20    17.1   391.1      15.9    378.4    0.93       26     15.9    366.2    0.93       54     16.0    350.4    0.94       91       
 24    16.3   400.9      16.8    385.4    1.03       27     16.3    371.6    1.00       55     16.8    357.0    1.03       94       
 28    17.7   410.4      18.2    399.1    1.03       28     18.0    383.7    1.02       59     16.9    362.8    0.95       93       
 32    16.5   421.6      16.5    406.2    1.00       25     16.6    391.8    1.01       53     16.5    370.6    1.00       89       
 36    16.4   428.7      15.9    412.6    0.97       24     16.0    399.1    0.98       50     15.9    376.9    0.97       84       
 40    16.4   431.6      16.5    414.3    1.01       25     16.1    400.1    0.98       50     16.4    378.3    1.00       87       
 44    16.3   433.8      16.5    416.0    1.01       25     15.9    399.8    0.98       50     16.2    378.3    0.99       86       
 48    16.6   432.9      16.4    417.0    0.99       25     16.4    402.2    0.99       51     16.3    378.4    0.98       86       
 52    16.9   436.2      16.4    419.3    0.97       24     16.5    404.0    0.98       51     16.3    383.2    0.96       85       
 56    16.0   427.7      16.1    415.4    1.01       24     15.3    398.1    0.96       48     15.8    376.7    0.99       84       
 60    17.6   439.2      17.1    423.2    0.97       25     15.6    403.3    0.89       48     16.0    379.5    0.91       84       
 64    17.3   443.4      16.9    427.3    0.98       25     16.3    408.5    0.94       50     16.7    388.4    0.97       86       
 68    16.9   447.3      16.8    432.1    0.99       24     16.3    416.5    0.96       49     15.6    393.6    0.92       79       
 72    15.9   445.9      16.2    432.8    1.02       23     16.1    418.2    1.01       48     15.6    396.3    0.98       79       
 76    14.9   434.9      15.7    424.4    1.05       23     15.1    408.9    1.01       46     16.0    392.9    1.07       82       
 80    15.9   433.3      15.3    418.5    0.96       23     15.6    405.2    0.98       48     16.7    386.2    1.05       87       
 84    16.7   429.5      17.1    422.5    1.02       25     16.5    406.5    0.99       51     16.4    374.2    0.98       88       
 88    16.2   433.8      15.4    420.3    0.95       23     14.7    410.5    0.91       45                                          
 92    15.1   428.4      15.7    425.3    1.04       23     14.5    407.8    0.96       45                                          
 96    15.2   424.7      16.0    423.9    1.05       24     13.4    395.4    0.88       42                                          
100    15.5   424.1      14.9    420.7    0.96       22     16.0    407.5    1.03       49                                          
104    14.6   424.6      13.5    414.5    0.92       20                                                                             
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.6   295.3      17.5    291.0    0.99       39     17.5    285.3    0.99       78     16.8    274.7    0.95      125       
SD(D)   0.4               0.8             0.02        9      0.9             0.03       18      1.0             0.03       28       
CV(E)   2.3               4.4             2.4      22.8      5.3             3.1      22.6      5.8             3.6      22.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   16.8   415.7      16.6    401.1    0.99       26     16.4    386.8    0.98       53     16.4    366.5    0.98       89       
SD(D)   0.5               0.6             0.03        2      0.6             0.02        4      0.3             0.03        5       
CV(E)   2.8               3.8             3.1       6.7      3.8             2.5       6.7      2.0             3.0       5.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   16.0   433.6      15.9    423.1    1.00       23     15.5    407.2    0.96       47     16.1    386.0    0.98       84       
SD(D)   0.9               1.0             0.04        1      0.9             0.05        2      0.5             0.06        3       
CV(E)   5.9               6.3             4.1       5.7      5.8             5.1       5.2      2.8             5.7       4.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                    
                    CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                                                      
=============================================================================                                                       
                 2000 PPM(STOP)                     5000 PPM(STOP)                                                                  
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  4    18.0    230.4     0.99     156     16.2    211.0     0.90     384                                                            
  8    16.2    284.8     0.93     114     14.1    246.6     0.81     286                                                            
 12    16.4    315.7     0.95     104     14.5    263.1     0.84     276                                                            
 16    16.4    340.5     0.95      97     15.8    279.1     0.91     282                                                            
 20    16.7    359.2     0.98      93     16.6    296.7     0.97     281                                                            
 24    16.5    370.6     1.01      89     16.1    304.8     0.99     264                                                            
 28    17.5    381.0     0.99      92     17.4    311.8     0.98     278                                                            
 32    16.2    389.9     0.98      83     16.2    320.6     0.98     252                                                            
 36    16.0    398.1     0.98      81     15.7    327.5     0.96     239                                                            
 40    16.2    399.9     0.99      81     15.8    329.0     0.96     241                                                            
 44    16.4    403.2     1.01      81     15.7    331.4     0.96     238                                                            
 48    16.2    402.1     0.98      80     16.1    333.5     0.97     241                                                            
 52    16.9    407.9     1.00      83     16.2    336.3     0.96     242                                                            
 56    16.1    401.7     1.01      80     15.5    329.3     0.97     235                                                            
 60    17.3    411.0     0.98      84     16.6    341.8     0.94     242                                                            
 64    17.0    417.0     0.98      82     16.0    345.9     0.92     232                                                            
 68    16.4    421.9     0.97      78     15.8    356.2     0.93     221                                                            
 72    15.9    421.1     1.00      76     16.0    363.9     1.01     220                                                            
 76    15.8    415.3     1.06      76     16.0    366.8     1.07     218                                                            
 80    15.3    408.3     0.96      75     15.5    360.3     0.97     215                                                            
 84    15.7    403.4     0.94      78     16.8    368.1     1.01     229                                                            
 88    16.2    413.0     1.00      79                                                                                               
 92    15.0    407.9     0.99      74                                                                                               
 96    14.2    412.0     0.93      69                                                                                               
100    14.2    412.3     0.92      69                                                                                               
104    15.4    404.2     1.05      76                                                                                               
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   16.9    276.9     0.96     125     14.9    240.2     0.85     315                                                            
SD(D)   1.0              0.04      28      1.1              0.05      60                                                            
CV(E)   5.8              3.7     22.3      7.4              5.3     19.0                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   16.5    385.2     0.99      86     16.2    317.1     0.96     256                                                            
SD(D)   0.4              0.02       6      0.5              0.02      19                                                            
CV(E)   2.6              1.9      7.0      3.2              2.2      7.3                                                            
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   15.7    411.5     0.98      76     16.0    354.0     0.98     226                                                            
SD(D)   0.9              0.04       4      0.5              0.05      10                                                            
CV(E)   6.0              4.3      5.8      3.0              5.0      4.3                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                               CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                           
==================================================================================================================================  
           0 PPM                      625 PPM                            1250 PPM                           2000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4    11.3   145.0      11.5    143.7     1.02      50     12.0    144.8     1.06     103     11.5    142.8     1.02     161       
  8     9.9   170.9       9.9    168.0     1.00      37     10.2    169.6     1.03      75      9.8    167.7     0.99     117       
 12    10.2   185.2      10.0    180.1     0.98      35     10.2    182.4     1.00      70     10.1    181.0     0.99     112       
 16    10.1   195.4      10.3    193.4     1.02      33     10.5    192.9     1.04      68     10.3    192.6     1.02     106       
 20    10.2   203.1       9.6    199.7     0.94      30     10.1    199.7     0.99      63      9.9    195.5     0.97     101       
 24    10.0   206.9      10.2    204.3     1.02      31     10.4    203.6     1.04      64     10.3    201.3     1.03     102       
 28    10.7   212.4      10.9    209.8     1.02      33     11.1    209.0     1.04      67     10.4    206.3     0.97     101       
 32    10.3   221.2      10.4    217.4     1.01      30     10.5    215.8     1.02      61     10.2    212.8     0.99      96       
 36     9.8   224.7      10.0    221.2     1.02      28     10.1    219.4     1.03      57      9.8    214.3     1.00      92       
 40    10.0   226.5      10.1    224.6     1.01      28     10.3    223.5     1.03      58     10.0    215.6     1.00      93       
 44    10.2   231.0      10.2    228.0     1.00      28     10.6    227.2     1.04      58     10.3    219.6     1.01      93       
 48    10.5   235.8      10.4    231.9     0.99      28     10.7    231.2     1.02      58     10.2    222.4     0.97      91       
 52    10.7   239.3      10.6    235.4     0.99      28     11.0    234.7     1.03      59     10.5    223.5     0.98      94       
 56    11.3   244.0      11.4    240.6     1.01      30     11.1    240.7     0.98      58     10.9    227.3     0.96      96       
 60    11.6   253.9      11.0    246.6     0.95      28     11.1    246.8     0.96      56     10.8    229.6     0.93      94       
 64    11.1   258.3      11.3    256.2     1.02      28     11.5    251.1     1.04      57     11.0    233.7     0.99      94       
 68    11.7   266.1      11.8    262.8     1.01      28     12.0    259.0     1.03      58     10.8    240.8     0.92      89       
 72    11.9   271.3      12.2    267.1     1.03      29     12.0    266.8     1.01      56     11.5    242.5     0.97      95       
 76    12.2   276.0      12.2    270.8     1.00      28     11.4    268.1     0.93      53     11.4    242.5     0.93      94       
 80    12.0   281.2      11.8    273.9     0.98      27     11.6    272.0     0.97      53     11.2    246.5     0.93      91       
 84    12.0   283.6      12.4    275.0     1.03      28     12.6    271.9     1.05      58     11.3    247.1     0.94      91       
 88    11.7   284.0      12.5    278.2     1.07      28     12.0    273.7     1.03      55     11.3    250.0     0.97      91       
 92    11.9   290.4      12.2    285.4     1.03      27     11.9    281.7     1.00      53     10.9    257.1     0.92      85       
 96    11.7   291.3      11.8    287.2     1.01      26     11.7    287.4     1.00      51     11.3    263.9     0.97      86       
100    11.9   293.8      11.7    290.8     0.98      25     11.8    292.8     0.99      50     11.3    273.2     0.95      83       
104    11.5   299.3      12.1    301.6     1.05      25     12.3    297.7     1.07      52     11.7    274.8     1.02      85       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   10.5   167.0      10.5    163.9     1.00      40     10.8    165.6     1.03      83     10.5    163.8     1.00     130       
SD(D)   0.7               0.9              0.02       8      1.0              0.03      18      0.9              0.02      27       
CV(E)   7.0               8.7              1.9     20.7      9.6              3.0     21.9      8.8              1.6     21.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   10.3   219.6      10.3    216.6     1.00      30     10.5    215.7     1.03      61     10.2    210.4     0.99      97       
SD(D)   0.3               0.4              0.02       2      0.3              0.02       4      0.2              0.02       5       
CV(E)   3.0               3.5              2.4      6.7      3.3              1.5      6.5      2.1              2.1      5.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   11.7   276.4      11.9    272.0     1.01      27     11.8    270.0     1.00      55     11.2    248.4     0.95      90       
SD(D)   0.3               0.4              0.03       1      0.4              0.04       3      0.3              0.03       4       
CV(E)   2.6               3.6              3.1      5.1      3.7              3.8      5.0      2.6              3.0      4.8       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                              DIAGNOSTIC TRAILER REPORT                                                             
                                              FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                     
                                              CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                            
==================================================================================================================================  
           0 PPM                   625 PPM                  1250 PPM                 2000 PPM              2000 PPM(STOP)           
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B              122.1  70                121.9  60                122.5  60                122.0  60                122.8  70      
  1              122.1  70                121.9  60                122.5  60                122.0  60                122.8  70      
  4  18.1 11789  238.8  70    18.4  9746  237.1  60    18.5  9730  234.7  60    17.9  9695  228.0  60    18.0 11299  230.4  70      
  8  17.5 11732  303.3  70    17.0 10027  299.4  60    16.8  9915  294.8  60    16.1  9915  281.5  60    16.2 11579  284.8  70      
 12  17.3 11625  343.7  70    17.0  9920  336.6  60    17.1  9900  326.5  60    16.5  9890  314.7  60    16.4 11509  315.7  70      
 16  17.3  9838  369.9  60    16.8  9935  362.6  60    16.7  9812  349.8  60    16.3  9074  329.4  60    16.4  9965  340.5  60      
 20  17.1  9470  391.1  60    15.9  9940  378.4  60    15.9  9846  366.2  60    16.0  9825  350.4  60    16.7  9927  359.2  60      
 24  16.3 10071  400.9  60    16.8 10030  385.4  60    16.3  9988  371.6  60    16.8  9843  357.0  60    16.5 10089  370.6  60      
 28  17.7 10012  410.4  60    18.2  9601  399.1  60    18.0  9855  383.7  60    16.9  9748  362.8  60    17.5  9920  381.0  60      
 32  16.5 10034  421.6  60    16.5  9930  406.2  60    16.6  9887  391.8  60    16.5  9878  370.6  60    16.2  9972  389.9  60      
 36  16.4  9744  428.7  60    15.9  9941  412.6  60    16.0  9930  399.1  60    15.9  9893  376.9  60    16.0 10069  398.1  60      
 40  16.4 10034  431.6  60    16.5  9945  414.3  60    16.1  9920  400.1  60    16.4  9738  378.3  60    16.2  9758  399.9  58      
 44  16.3  9937  433.8  60    16.5  9913  416.0  60    15.9  9263  399.8  56    16.2  9890  378.3  60    16.4  9604  403.2  58      
 48  16.6  9921  432.9  60    16.4 10056  417.0  60    16.4  9565  402.2  57    16.3 10065  378.4  60    16.2  9733  402.1  58      
 52  16.9  9946  436.2  60    16.4  9744  419.3  60    16.5  9262  404.0  54    16.3  9626  383.2  59    16.9  9612  407.9  58      
 56  16.0  9986  427.7  60    16.1  9746  415.4  59    15.3  9179  398.1  55    15.8  9438  376.7  57    16.1  9483  401.7  57      
 60  17.6  9973  439.2  60    17.1  9749  423.2  59    15.6  9070  403.3  55    16.0  8528  379.5  50    17.3  9474  411.0  56      
 64  17.3  9915  443.4  59    16.9  9700  427.3  58    16.3  8927  408.5  54    16.7  7583  388.4  46    17.0  9241  417.0  55      
 68  16.9  9792  447.3  59    16.8  9238  432.1  56    16.3  8849  416.5  54    15.6  6820  393.6  40    16.4  8996  421.9  54      
 72  15.9  9850  445.9  59    16.2  9178  432.8  55    16.1  8046  418.2  49    15.6  5669  396.3  34    15.9  8784  421.1  52      
 76  14.9  9393  434.9  59    15.7  8843  424.4  54    15.1  6973  408.9  42    16.0  3838  392.9  23    15.8  8109  415.3  49      
 80  15.9  9185  433.3  55    15.3  8626  418.5  51    15.6  6859  405.2  42    16.7  2379  386.2  15    15.3  7544  408.3  46      
 84  16.7  9182  429.5  54    17.1  7787  422.5  47    16.5  5847  406.5  36    16.4  1415  374.2   8    15.7  6368  403.4  38      
 88  16.2  9035  433.8  54    15.4  7290  420.3  44    14.7  5113  410.5  31    16.9   672  367.8   4    16.2  5324  413.0  32      
 92  15.1  8821  428.4  52    15.7  5516  425.3  32    14.5  3533  407.8  21    17.2   334  422.8   2    15.0  4710  407.9  28      
 96  15.2  8267  424.7  49    16.0  4704  423.9  28    13.4  2677  395.4  16                             14.2  3759  412.0  22      
100  15.5  7708  424.1  46    14.9  4138  420.7  25    16.0  1327  407.5   8                             14.2  2917  412.3  18      
104  14.6  6581  424.6  40    13.5  3336  414.5  19    14.1   428  395.4   3                             15.4  1825  404.2  11      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          252.0                    248.7                    244.6                    236.6                    238.4          
14 TO 52         415.7                    401.1                    386.8                    366.5                    385.2          
 > 52            433.6                    423.1                    406.3                    387.8                    411.5          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                                   
CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                                                                          
==============================                                                                                                      
       5000 PPM(STOP)                                                                                                               
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B              121.4  70                                                                                                          
  1              121.4  70                                                                                                          
  4  16.2 11340  211.0  70                                                                                                          
  8  14.1 11520  246.6  70                                                                                                          
 12  14.5 11372  263.1  70                                                                                                          
 16  15.8  9972  279.1  60                                                                                                          
 20  16.6  9908  296.7  60                                                                                                          
 24  16.1 10008  304.8  60                                                                                                          
 28  17.4  9907  311.8  60                                                                                                          
 32  16.2 10020  320.6  60                                                                                                          
 36  15.7 10063  327.5  60                                                                                                          
 40  15.8 10084  329.0  60                                                                                                          
 44  15.7  9614  331.4  58                                                                                                          
 48  16.1  9552  333.5  57                                                                                                          
 52  16.2  8952  336.3  52                                                                                                          
 56  15.5  7893  329.3  45                                                                                                          
 60  16.6  7063  341.8  40                                                                                                          
 64  16.0  6378  345.9  38                                                                                                          
 68  15.8  5562  356.2  33                                                                                                          
 72  16.0  4490  363.9  25                                                                                                          
 76  16.0  3583  366.8  22                                                                                                          
 80  15.5  2380  360.3  14                                                                                                          
 84  16.8  1341  368.1   8                                                                                                          
 88  15.2   648  348.8   4                                                                                                          
 92  14.4   168  320.5   1                                                                                                          
 96  16.2   167  348.9   1                                                                                                          
100                                                                                                                                 
104                                                                                                                                 
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          210.5                                                                                                              
14 TO 52         317.1                                                                                                              
 > 52            350.0                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                 DIAGNOSTIC TRAILER REPORT                                                                          
                                 FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                
                                 CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                                         
=========================================================================================================                           
           0 PPM                   625 PPM                  1250 PPM                 2000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              104.5  60                103.9  60                104.3  60                104.7  60                               
  1              104.5  60                103.9  60                104.3  60                104.7  60                               
  4  11.3 10116  145.0  60    11.5  9732  143.7  60    12.0  9720  144.8  60    11.5  9702  142.8  60                               
  8   9.9 10052  170.9  60     9.9 10026  168.0  60    10.2  9912  169.6  60     9.8  9914  167.7  60                               
 12  10.2  9478  185.2  60    10.0  9931  180.1  60    10.2  9673  182.4  60    10.1  9795  181.0  60                               
 16  10.1  9930  195.4  60    10.3  9918  193.4  60    10.5  9774  192.9  60    10.3  9834  192.6  60                               
 20  10.2 10002  203.1  60     9.6  9901  199.7  60    10.1  9793  199.7  60     9.9  9804  195.5  60                               
 24  10.0 10111  206.9  60    10.2 10110  204.3  60    10.4 10008  203.6  60    10.3  9883  201.3  60                               
 28  10.7 10006  212.4  60    10.9  9922  209.8  60    11.1  9874  209.0  60    10.4  9816  206.3  60                               
 32  10.3 10059  221.2  60    10.4  9929  217.4  60    10.5  9888  215.8  60    10.2  9890  212.8  60                               
 36   9.8 10059  224.7  60    10.0  9924  221.2  60    10.1  9920  219.4  60     9.8  9870  214.3  60                               
 40  10.0 10015  226.5  60    10.1  9933  224.6  60    10.3  9900  223.5  60    10.0  9864  215.6  60                               
 44  10.2  9928  231.0  60    10.2  9894  228.0  60    10.6  9894  227.2  60    10.3  9867  219.6  60                               
 48  10.5 10066  235.8  60    10.4 10056  231.9  60    10.7 10056  231.2  60    10.2 10062  222.4  60                               
 52  10.7  9939  239.3  60    10.6  9899  235.4  60    11.0  9761  234.7  60    10.5  9748  223.5  60                               
 56  11.3 10029  244.0  60    11.4  9900  240.6  60    11.1  9706  240.7  59    10.9  9721  227.3  60                               
 60  11.6  9824  253.9  59    11.0  9912  246.6  60    11.1  9729  246.8  59    10.8  9696  229.6  60                               
 64  11.1  9919  258.3  59    11.3  9883  256.2  59    11.5  9592  251.1  58    11.0  9918  233.7  60                               
 68  11.7  9654  266.1  58    11.8  9691  262.8  59    12.0  9494  259.0  58    10.8  9565  240.8  59                               
 72  11.9  9156  271.3  58    12.2  8770  267.1  58    12.0  9582  266.8  58    11.5  9466  242.5  58                               
 76  12.2  9427  276.0  58    12.2  9214  270.8  57    11.4  9044  268.1  56    11.4  9338  242.5  58                               
 80  12.0  9611  281.2  58    11.8  9255  273.9  56    11.6  9215  272.0  56    11.2  9446  246.5  58                               
 84  12.0  9738  283.6  58    12.4  9151  275.0  56    12.6  8893  271.9  55    11.3  9210  247.1  57                               
 88  11.7  9699  284.0  58    12.5  9240  278.2  55    12.0  8952  273.7  53    11.3  9247  250.0  55                               
 92  11.9  9427  290.4  56    12.2  9241  285.4  55    11.9  8736  281.7  52    10.9  8595  257.1  52                               
 96  11.7  9431  291.3  56    11.8  9148  287.2  55    11.7  8532  287.4  51    11.3  8007  263.9  48                               
100  11.9  9079  293.8  54    11.7  8507  290.8  52    11.8  7865  292.8  49    11.3  7081  273.2  43                               
104  11.5  7938  299.3  48    12.1  7759  301.6  47    12.3  6434  297.7  39    11.7  5400  274.8  33                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          151.4                    148.9                    150.3                    149.0                                   
14 TO 52         219.6                    216.6                    215.7                    210.4                                   
 > 52            276.4                    272.0                    270.0                    248.4                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.