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TDMS Study 05203-08 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                              O-NITROTOLUENE                                             DATE: 11/16/00  
EXPERIMENT: 05203 TEST: 08                                                                                        TIME: 09:00:51    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62340D     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      O-NITROTOLUENE                                              DATE: 11/16/00    
EXPERIMENT: 05203 TEST: 08                                                                                        TIME:  9:14:40    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: DOSED FEED                                             NTP:  62340D      
CONT: N01-ES-55393                                                                                                CAS: 88-72-2      
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                               
                                      TWO YEAR DOSED FEED STUDY OF O-NITROTOLUENE                                                   
==========================================================================================================================          
WEEK     0 PPM                  625 PPM                  1250 PPM                 2000 PPM                 2000 PPM(STOP)           
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B       122.1       70       121.9     99.8    60     122.5    100.3    60     122.0     99.9    60     122.8    100.6    70      
  1       122.1       70       121.9     99.8    60     122.5    100.3    60     122.0     99.9    60     122.8    100.6    70      
  4       238.8       70       237.1     99.3    60     234.7     98.3    60     228.0     95.5    60     230.4     96.5    70      
  8       303.3       70       299.4     98.7    60     294.8     97.2    60     281.5     92.8    60     284.8     93.9    70      
 12       343.7       70       336.6     97.9    60     326.5     95.0    60     314.7     91.6    60     315.7     91.9    70      
 16       369.9       60 (I)   362.6     98.0    60     349.8     94.6    60     329.4     89.1    60     340.5     92.1    60 (I)  
 20       391.1       60       378.4     96.8    60     366.2     93.6    60     350.4     89.6    60     359.2     91.8    60      
 24       400.9       60       385.4     96.1    60     371.6     92.7    60     357.0     89.0    60     370.6     92.4    60      
 28       410.4       60       399.1     97.2    60     383.7     93.5    60     362.8     88.4    60     381.0     92.8    60      
 32       421.6       60       406.2     96.3    60     391.8     92.9    60     370.6     87.9    60     389.9     92.5    60      
 36       428.7       60       412.6     96.2    60     399.1     93.1    60     376.9     87.9    60     398.1     92.9    60      
 40       431.6       60       414.3     96.0    60     400.1     92.7    60     378.3     87.7    60     399.9     92.7    58      
 44       433.8       60       416.0     95.9    60     399.8     92.2    56*    378.3     87.2    60     403.2     92.9    58      
 48       432.9       60       417.0     96.3    60     402.2     92.9    57     378.4     87.4    60     402.1     92.9    58      
 52       436.2       60       419.3     96.1    60     404.0     92.6    54*    383.2     87.8    59     407.9     93.5    58      
 56       427.7       60       415.4     97.1    59     398.1     93.1    55     376.7     88.1    57     401.7     93.9    57      
 60       439.2       60       423.2     96.4    59     403.3     91.8    55     379.5     86.4    50     411.0     93.6    56      
 64       443.4       59       427.3     96.4    58     408.5     92.1    54     388.4     87.6    46     417.0     94.0    55      
 68       447.3       59       432.1     96.6    56     416.5     93.1    54     393.6     88.0    40     421.9     94.3    54      
 72       445.9       59       432.8     97.1    55     418.2     93.8    49     396.3     88.9    34     421.1     94.4    52      
 76       434.9       59       424.4     97.6    54     408.9     94.0    42     392.9     90.3    23     415.3     95.5    49      
 80       433.3       55       418.5     96.6    51     405.2     93.5    42     386.2     89.1    15     408.3     94.2    46      
 84       429.5       54       422.5     98.4    47     406.5     94.6    36     374.2     87.1     8     403.4     93.9    38      
 88       433.8       54       420.3     96.9    44     410.5     94.6    31     367.8     84.8     4     413.0     95.2    32      
 92       428.4       52       425.3     99.3    32     407.8     95.2    21     422.8     98.7     2     407.9     95.2    28      
 96       424.7       49       423.9     99.8    28     395.4     93.1    16                              412.0     97.0    22      
100       424.1       46       420.7     99.2    25     407.5     96.1     8                              412.3     97.2    18      
104       424.6       40       414.5     97.6    19     395.4     93.1     3                              404.2     95.2    11      
TERM. SAC.            39                         18                        3                        0                       11      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                                                  
TWO YEAR DOSED FEED STUDY OF O-NITROTOLUENE                                                                                         
===============================                                                                                                     
     5000 PPM(STOP)                                                                                                                 
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B   121.4     99.4    70                                                                                                          
  1   121.4     99.4    70                                                                                                          
  4   211.0     88.4    70                                                                                                          
  8   246.6     81.3    70                                                                                                          
 12   263.1     76.5    70                                                                                                          
 16   279.1     75.5    60 (I)                                                                                                      
 20   296.7     75.9    60                                                                                                          
 24   304.8     76.0    60                                                                                                          
 28   311.8     76.0    60                                                                                                          
 32   320.6     76.0    60                                                                                                          
 36   327.5     76.4    60                                                                                                          
 40   329.0     76.2    60                                                                                                          
 44   331.4     76.4    58                                                                                                          
 48   333.5     77.0    57                                                                                                          
 52   336.3     77.1    52                                                                                                          
 56   329.3     77.0    45                                                                                                          
 60   341.8     77.8    40                                                                                                          
 64   345.9     78.0    38                                                                                                          
 68   356.2     79.6    33                                                                                                          
 72   363.9     81.6    25                                                                                                          
 76   366.8     84.3    22                                                                                                          
 80   360.3     83.2    14                                                                                                          
 84   368.1     85.7     8                                                                                                          
 88   348.8     80.4     4                                                                                                          
 92   320.5     74.8     1                                                                                                          
 96   348.9     82.2     1                                                                                                          
100                                                                                                                                 
104                                                                                                                                 
TERM. SAC.               0                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                                TWO YEAR DOSED FEED STUDY OF O-NITROTOLUENE                                                         
==========================================================================================================                          
WEEK     0 PPM                  625 PPM                  1250 PPM                 2000 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B       104.5       60       103.9     99.4    60     104.3     99.8    60     104.7    100.2    60                               
  1       104.5       60       103.9     99.4    60     104.3     99.8    60     104.7    100.2    60                               
  4       145.0       60       143.7     99.1    60     144.8     99.9    60     142.8     98.5    60                               
  8       170.9       60       168.0     98.3    60     169.6     99.2    60     167.7     98.1    60                               
 12       185.2       60       180.1     97.2    60     182.4     98.5    60     181.0     97.7    60                               
 16       195.4       60       193.4     99.0    60     192.9     98.7    60     192.6     98.6    60                               
 20       203.1       60       199.7     98.3    60     199.7     98.3    60     195.5     96.3    60                               
 24       206.9       60       204.3     98.7    60     203.6     98.4    60     201.3     97.3    60                               
 28       212.4       60       209.8     98.8    60     209.0     98.4    60     206.3     97.1    60                               
 32       221.2       60       217.4     98.3    60     215.8     97.6    60     212.8     96.2    60                               
 36       224.7       60       221.2     98.4    60     219.4     97.6    60     214.3     95.4    60                               
 40       226.5       60       224.6     99.2    60     223.5     98.7    60     215.6     95.2    60                               
 44       231.0       60       228.0     98.7    60     227.2     98.4    60     219.6     95.1    60                               
 48       235.8       60       231.9     98.3    60     231.2     98.0    60     222.4     94.3    60                               
 52       239.3       60       235.4     98.4    60     234.7     98.1    60     223.5     93.4    60                               
 56       244.0       60       240.6     98.6    60     240.7     98.6    59     227.3     93.2    60                               
 60       253.9       59       246.6     97.1    60     246.8     97.2    59     229.6     90.4    60                               
 64       258.3       59       256.2     99.2    59     251.1     97.2    58     233.7     90.5    60                               
 68       266.1       58       262.8     98.8    59     259.0     97.3    58     240.8     90.5    59                               
 72       271.3       58       267.1     98.5    58     266.8     98.3    58     242.5     89.4    58                               
 76       276.0       58       270.8     98.1    57     268.1     97.1    56     242.5     87.9    58                               
 80       281.2       58       273.9     97.4    56     272.0     96.7    56     246.5     87.7    58                               
 84       283.6       58       275.0     97.0    56     271.9     95.9    55     247.1     87.1    57                               
 88       284.0       58       278.2     98.0    55     273.7     96.4    53     250.0     88.0    55                               
 92       290.4       56       285.4     98.3    55     281.7     97.0    52     257.1     88.5    52                               
 96       291.3       56       287.2     98.6    55     287.4     98.7    51     263.9     90.6    48                               
100       293.8       54       290.8     99.0    52     292.8     99.7    49     273.2     93.0    43                               
104       299.3       48       301.6    100.8    47     297.7     99.5    39     274.8     91.8    33                               
TERM. SAC.            47                         47                       39                       33                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.