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TDMS Study 05203-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:33:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                     RATS, FINAL#1; CORE STUDY                                                      
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 002    0 PPM                                                                         
                                       INCLUDE 003    625 PPM                                                                       
                                       INCLUDE 004    625 PPM                                                                       
                                       INCLUDE 005    1250 PPM                                                                      
                                       INCLUDE 006    1250 PPM                                                                      
                                       INCLUDE 007    2000 PPM                                                                      
                                       INCLUDE 008    2000 PPM                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:33:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:33:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS                                            
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Mammary Gland                          Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Skin                                                                                                                                
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Fibroma                                                                                      
                                       Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma                                                                                 
                                       Keratoacanthoma                                                                              
                                       Lipoma                                                                                       
Testes                                 Adenoma                                                                                      
Thyroid Gland: C-Cell                  Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Thyroid Gland: Follicular Cell         Carcinoma or Adenoma                                                                         
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Mesothelioma: Benign, Malignant, NOS                                                         
                                       Mesothelioma: Malignant                                                                      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Clitoral/Preputial Gland               Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Mammary Gland                          Carcinoma or Adenoma                                                                         
                                       Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:33:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Mesentery                              Lipoma                                                                                       
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Skin                                   Fibroma                                                                                      
                                       Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma                                                                                 
Thyroid Gland: C-Cell                  Adenoma                                                                                      
Uterus                                 Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                   O-NITROTOLUENE          
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)   |2/60 (3%)    0/60 (0%)    0/60 (0%)    1/59 (2%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      1/22.19     |2/56.86      0/55.69      0/53.74      1/52.49      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |3.5%         0.0%         0.0%         1.9%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |2/47 (4%)    0/47 (0%)    0/39 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          471         |729 (T)      ---          ---          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.156      (e)          (e)          P=0.441     |P=0.417N     P=0.239N     P=0.280N     P=0.611N     | 
|POLY 3             |     P=0.271      (e)          (e)          P=0.349     |P=0.343N     P=0.242N     P=0.250N     P=0.528N     | 
|POLY 1.5           |     P=0.203      (e)          (e)          P=0.412     |P=0.343N     P=0.240N     P=0.245N     P=0.517N     | 
|POLY 6             |     P=0.454      (e)          (e)          P=0.286     |P=0.343N     P=0.245N     P=0.258N     P=0.546N     | 
|LOGISTIC REGRESSION|     P=0.359      (e)          (e)          P=0.931     |P=0.359N     (e)          (e)          P=0.533N     | 
|COCH-ARM / FISHERS |     P=0.188      (e)          (e)          P=0.500     |P=0.342N     P=0.248N     P=0.248N     P=0.506N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    4/60 (7%)    6/60 (10%)   2/59 (3%)   |2/60 (3%)    0/60 (0%)    0/60 (0%)    1/58 (2%)    | 
|POLY-3 RATE (b)    |     2/53.85      4/45.15      6/36.81      2/22.52     |2/56.95      0/55.69      0/53.74      1/52.47      | 
|POLY-3 PERCENT (g) |     3.7%         8.9%         16.3%        8.9%        |3.5%         0.0%         0.0%         1.9%         | 
|TERMINAL (d)       |     2/39 (5%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      567          531          471         |707          ---          ---          603          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.139      P<0.001 **   P=0.119     |P=0.393N     P=0.246N     P=0.274N     P=0.578N     | 
|POLY 3             |     P=0.064      P=0.261      P=0.048 *    P=0.380     |P=0.348N     P=0.243N     P=0.251N     P=0.528N     | 
|POLY 1.5           |     P=0.189      P=0.294      P=0.077      P=0.518     |P=0.347N     P=0.241N     P=0.245N     P=0.520N     | 
|POLY 6             |     P=0.012 *    P=0.218      P=0.024 *    P=0.241     |P=0.348N     P=0.245N     P=0.259N     P=0.545N     | 
|LOGISTIC REGRESSION|     P=0.243      P=0.317      P=0.068      P=0.716     |P=0.333N     P=0.241N     P=0.251N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.482      P=0.340      P=0.136      P=0.684     |P=0.345N     P=0.248N     P=0.248N     P=0.513N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    0/59 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/58 (0%)    | 
|POLY-3 RATE (b)    |     2/53.85      0/44.05      0/34.77      0/21.19     |0/56.86      0/55.69      0/53.74      0/52.03      | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403N     P=0.420N     P=0.840N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.104N     P=0.285N     P=0.345N     P=0.466N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.080N     P=0.263N     P=0.295N     P=0.358N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.151N     P=0.319N     P=0.423N     P=0.594N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.403N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.068N     P=0.248N     P=0.248N     P=0.252N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    4/60 (7%)    6/60 (10%)   2/59 (3%)   |2/60 (3%)    0/60 (0%)    0/60 (0%)    1/58 (2%)    | 
|POLY-3 RATE (b)    |     4/53.85      4/45.15      6/36.81      2/22.52     |2/56.95      0/55.69      0/53.74      1/52.47      | 
|POLY-3 PERCENT (g) |     7.4%         8.9%         16.3%        8.9%        |3.5%         0.0%         0.0%         1.9%         | 
|TERMINAL (d)       |     4/39 (10%)   1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    0/39 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      567          531          471         |707          ---          ---          603          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.316      P=0.003 **   P=0.119     |P=0.393N     P=0.246N     P=0.274N     P=0.578N     | 
|POLY 3             |     P=0.220      P=0.543      P=0.170      P=0.584     |P=0.348N     P=0.243N     P=0.251N     P=0.528N     | 
|POLY 1.5           |     P=0.435      P=0.588      P=0.245      P=0.560N    |P=0.347N     P=0.241N     P=0.245N     P=0.520N     | 
|POLY 6             |     P=0.068      P=0.479      P=0.094      P=0.370     |P=0.348N     P=0.245N     P=0.259N     P=0.545N     | 
|LOGISTIC REGRESSION|     P=0.391      P=0.566      P=0.169      P=0.734     |P=0.333N     P=0.241N     P=0.251N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.356N     P=0.641N     P=0.372      P=0.348N    |P=0.345N     P=0.248N     P=0.248N     P=0.513N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    3/59 (5%)    2/58 (3%)    1/56 (2%)   |12/59 (20%)  9/57 (16%)   3/54 (6%)    3/53 (6%)    | 
|POLY-3 RATE (b)    |     2/53.85      3/44.40      2/33.95      1/20.14     |12/55.88     9/52.86      3/48.18      3/47.50      | 
|POLY-3 PERCENT (g) |     3.7%         6.8%         5.9%         5.0%        |21.5%        17.0%        6.2%         6.3%         | 
|TERMINAL (d)       |     2/39 (5%)    1/17 (6%)    0/3 (0%)     0/0 (0%)    |11/46 (24%)  9/45 (20%)   3/36 (8%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      465          519          471         |726          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.182      P=0.282      P=0.209      P=0.441     |P=0.015N*    P=0.333N     P=0.040N*    P=0.065N     | 
|POLY 3             |     P=0.420      P=0.413      P=0.519      P=0.634     |P=0.005N**   P=0.366N     P=0.025N*    P=0.027N*    | 
|POLY 1.5           |     P=0.571N     P=0.449      P=0.591      P=0.674N    |P=0.004N**   P=0.358N     P=0.023N*    P=0.024N*    | 
|POLY 6             |     P=0.242      P=0.362      P=0.416      P=0.476     |P=0.006N**   P=0.374N     P=0.029N*    P=0.033N*    | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.616      P=0.648      P=0.869N    |P=0.016N*    P=0.357N     P=0.043N*    P=0.065N     | 
|COCH-ARM / FISHERS |     P=0.339N     P=0.492      P=0.678      P=0.526N    |P=0.004N**   P=0.347N     P=0.019N*    P=0.021N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    2/59 (3%)    0/58 (0%)    1/56 (2%)   |2/59 (3%)    4/57 (7%)    3/54 (6%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     2/53.89      2/43.50      0/33.03      1/19.91     |2/55.90      4/53.62      3/48.27      0/47.50      | 
|POLY-3 PERCENT (g) |     3.7%         4.6%         0.0%         5.0%        |3.6%         7.5%         6.2%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/17 (6%)    0/3 (0%)     0/0 (0%)    |1/46 (2%)    2/45 (4%)    2/36 (6%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     720          600          ---          581         |719          505          706          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.193      P=0.458      P=0.844N     P=0.169     |P=0.275N     P=0.327      P=0.402      P=0.327N     | 
|POLY 3             |     P=0.473N     P=0.614      P=0.358N     P=0.631     |P=0.229N     P=0.319      P=0.434      P=0.275N     | 
|POLY 1.5           |     P=0.359N     P=0.647      P=0.306N     P=0.676N    |P=0.216N     P=0.321      P=0.444      P=0.269N     | 
|POLY 6             |     P=0.621N     P=0.563      P=0.439N     P=0.473     |P=0.251N     P=0.317      P=0.421      P=0.285N     | 
|LOGISTIC REGRESSION|     P=0.631      P=0.618      P=0.694N     P=0.636     |P=0.196N     P=0.334      P=0.416      P=0.295N     | 
|COCH-ARM / FISHERS |     P=0.246N     P=0.684      P=0.256N     P=0.526N    |P=0.202N     P=0.323      P=0.458      P=0.275N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    5/59 (8%)    2/58 (3%)    2/56 (4%)   |14/59 (24%)  13/57 (23%)  6/54 (11%)   3/53 (6%)    | 
|POLY-3 RATE (b)    |     4/53.89      5/44.84      2/33.95      2/20.64     |14/55.92     13/53.62     6/48.27      3/47.50      | 
|POLY-3 PERCENT (g) |     7.4%         11.2%        5.9%         9.7%        |25.0%        24.3%        12.4%        6.3%         | 
|TERMINAL (d)       |     3/39 (8%)    2/17 (12%)   0/3 (0%)     0/0 (0%)    |12/46 (26%)  11/45 (24%)  5/36 (14%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     720          465          519          471         |719          505          706          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076      P=0.194      P=0.284      P=0.067     |P=0.010N*    P=0.528N     P=0.126N     P=0.031N*    | 
|POLY 3             |     P=0.542      P=0.387      P=0.559N     P=0.551     |P=0.003N**   P=0.550N     P=0.083N     P=0.009N**   | 
|POLY 1.5           |     P=0.398N     P=0.433      P=0.469N     P=0.592N    |P=0.002N**   P=0.546N     P=0.075N     P=0.008N**   | 
|POLY 6             |     P=0.323      P=0.322      P=0.633      P=0.343     |P=0.004N**   P=0.554N     P=0.094N     P=0.012N*    | 
|LOGISTIC REGRESSION|     P=0.266N     P=0.538      P=0.585N     P=0.607     |P=0.004N**   P=0.564N     P=0.121N     P=0.029N*    | 
|COCH-ARM / FISHERS |     P=0.182N     P=0.489      P=0.356N     P=0.373N    |P=0.002N**   P=0.541N     P=0.065N     P=0.007N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large: Colon/Rectum                                                                                                    | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    0/60 (0%)    0/60 (0%)    1/60 (2%)   |0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     1/53.85      0/44.05      0/34.77      1/22.27     |0/56.86      2/55.69      0/53.74      1/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         0.0%         0.0%         4.5%        |0.0%         3.6%         0.0%         1.9%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    2/47 (4%)    0/39 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          419         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295      P=0.654N     P=0.952N     P=0.475     |P=0.414      P=0.239      (e)          P=0.429      | 
|POLY 3             |     P=0.667      P=0.540N     P=0.583N     P=0.545     |P=0.483      P=0.233      (e)          P=0.487      | 
|POLY 1.5           |     P=0.621      P=0.522N     P=0.548N     P=0.649     |P=0.496      P=0.235      (e)          P=0.493      | 
|POLY 6             |     P=0.675N     P=0.565N     P=0.632N     P=0.419     |P=0.463      P=0.231      (e)          P=0.477      | 
|LOGISTIC REGRESSION|     P=0.566N     (e)          (e)          P=0.766N    |(e)          P=0.239      (e)          P=0.429      | 
|COCH-ARM / FISHERS |     P=0.618      P=0.500N     P=0.500N     P=0.752N    |P=0.510      P=0.248      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    1/59 (2%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.95      0/44.05      0/34.77      0/21.46     |1/56.86      1/54.87      1/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         0.0%         0.0%        |1.8%         1.8%         1.9%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     705          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.360N     P=0.401N     P=0.739N     P=1.000N    |P=0.387N     P=0.761      P=0.720      P=0.571N     | 
|POLY 3             |     P=0.103N     P=0.285N     P=0.346N     P=0.464N    |P=0.319N     P=0.753      P=0.748      P=0.513N     | 
|POLY 1.5           |     P=0.079N     P=0.263N     P=0.296N     P=0.355N    |P=0.312N     P=0.754      P=0.753      P=0.507N     | 
|POLY 6             |     P=0.151N     P=0.320N     P=0.424N     P=0.593N    |P=0.332N     P=0.751      P=0.741      P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.249N     P=0.341N     P=0.557N     P=0.986N    |P=0.387N     P=0.761      P=0.720      (e)          | 
|COCH-ARM / FISHERS |     P=0.067N     P=0.248N     P=0.248N     P=0.248N    |P=0.303N     P=0.748      P=0.752N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/59 (0%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.05      0/34.77      0/21.46     |0/56.86      0/54.87      1/54.37      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |0.0%         0.0%         1.8%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          525          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232      P=0.091      (e)          (e)         |P=0.550      (e)          P=0.497      (e)          | 
|POLY 3             |     P=0.622      P=0.196      (e)          (e)         |P=0.526      (e)          P=0.491      (e)          | 
|POLY 1.5           |     P=0.564N     P=0.214      (e)          (e)         |P=0.539      (e)          P=0.495      (e)          | 
|POLY 6             |     P=0.430      P=0.172      (e)          (e)         |P=0.503      (e)          P=0.486      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.091      (e)          (e)         |P=0.553      (e)          P=0.579      (e)          | 
|COCH-ARM / FISHERS |     P=0.382N     P=0.248      (e)          (e)         |P=0.551      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    1/59 (2%)    2/60 (3%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.95      2/44.05      0/34.77      0/21.46     |1/56.86      1/54.87      2/54.37      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         4.5%         0.0%         0.0%        |1.8%         1.8%         3.7%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     705          729 (T)      ---          ---         |729 (T)      729 (T)      525          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.605      P=0.414      P=0.739N     P=1.000N    |P=0.480N     P=0.761      P=0.455      P=0.571N     | 
|POLY 3             |     P=0.219N     P=0.618      P=0.346N     P=0.464N    |P=0.421N     P=0.753      P=0.484      P=0.513N     | 
|POLY 1.5           |     P=0.123N     P=0.653      P=0.296N     P=0.355N    |P=0.410N     P=0.754      P=0.491      P=0.507N     | 
|POLY 6             |     P=0.430N     P=0.565      P=0.424N     P=0.593N    |P=0.441N     P=0.751      P=0.475      P=0.523N     | 
|LOGISTIC REGRESSION|     P=0.632N     P=0.481      P=0.557N     P=0.986N    |P=0.378N     P=0.761      P=0.543      (e)          | 
|COCH-ARM / FISHERS |     P=0.063N     P=0.691N     P=0.248N     P=0.248N    |P=0.398N     P=0.748      P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    3/60 (5%)    3/60 (5%)    7/60 (12%)  |1/60 (2%)    0/59 (0%)    1/60 (2%)    6/60 (10%)   | 
|POLY-3 RATE (b)    |     2/53.94      3/44.45      3/35.90      7/25.88     |1/56.86      0/54.87      1/53.74      6/53.62      | 
|POLY-3 PERCENT (g) |     3.7%         6.8%         8.4%         27.1%       |1.8%         0.0%         1.9%         11.2%        | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    1/39 (3%)    4/33 (12%)   | 
|FIRST INCIDENCE    |     707          621          615          391         |729 (T)      ---          729 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.242      P=0.090      P<0.001 **  |P=0.002 **   P=0.500N     P=0.720      P=0.024 *    | 
|POLY 3             |     P=0.007 **   P=0.413      P=0.325      P=0.006 **  |P=0.005 **   P=0.507N     P=0.748      P=0.048 *    | 
|POLY 1.5           |     P=0.015 *    P=0.452      P=0.398      P=0.021 *   |P=0.006 **   P=0.506N     P=0.753      P=0.053      | 
|POLY 6             |     P=0.003 **   P=0.359      P=0.237      P<0.001 **  |P=0.005 **   P=0.509N     P=0.741      P=0.042 *    | 
|LOGISTIC REGRESSION|     P=0.041 *    P=0.369      P=0.405      P=0.263     |P=0.004 **   (e)          P=0.720      P=0.040 *    | 
|COCH-ARM / FISHERS |     P=0.045 *    P=0.500      P=0.500      P=0.081     |P=0.007 **   P=0.504N     P=0.752N     P=0.057      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    3/60 (5%)    3/60 (5%)    8/60 (13%)  |1/60 (2%)    0/59 (0%)    1/60 (2%)    6/60 (10%)   | 
|POLY-3 RATE (b)    |     3/53.94      3/44.45      3/35.90      8/26.50     |1/56.86      0/54.87      1/53.74      6/53.62      | 
|POLY-3 PERCENT (g) |     5.6%         6.8%         8.4%         30.2%       |1.8%         0.0%         1.9%         11.2%        | 
|TERMINAL (d)       |     2/39 (5%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    1/39 (3%)    4/33 (12%)   | 
|FIRST INCIDENCE    |     707          621          615          391         |729 (T)      ---          729 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.355      P=0.111      P<0.001 **  |P=0.002 **   P=0.500N     P=0.720      P=0.024 *    | 
|POLY 3             |     P=0.009 **   P=0.570      P=0.466      P=0.007 **  |P=0.005 **   P=0.507N     P=0.748      P=0.048 *    | 
|POLY 1.5           |     P=0.018 *    P=0.612      P=0.552      P=0.025 *   |P=0.006 **   P=0.506N     P=0.753      P=0.053      | 
|POLY 6             |     P=0.004 **   P=0.507      P=0.350      P<0.001 **  |P=0.005 **   P=0.509N     P=0.741      P=0.042 *    | 
|LOGISTIC REGRESSION|     P=0.041 *    P=0.504      P=0.510      P=0.229     |P=0.004 **   (e)          P=0.720      P=0.040 *    | 
|COCH-ARM / FISHERS |     P=0.052      P=0.660N     P=0.660N     P=0.102     |P=0.007 **   P=0.504N     P=0.752N     P=0.057      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    3/60 (5%)    3/60 (5%)    8/60 (13%)  |1/60 (2%)    0/59 (0%)    1/60 (2%)    6/60 (10%)   | 
|POLY-3 RATE (b)    |     3/53.94      3/44.45      3/35.90      8/26.50     |1/56.86      0/54.87      1/53.74      6/53.62      | 
|POLY-3 PERCENT (g) |     5.6%         6.8%         8.4%         30.2%       |1.8%         0.0%         1.9%         11.2%        | 
|TERMINAL (d)       |     2/39 (5%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    0/47 (0%)    1/39 (3%)    4/33 (12%)   | 
|FIRST INCIDENCE    |     707          621          615          391         |729 (T)      ---          729 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.355      P=0.111      P<0.001 **  |P=0.002 **   P=0.500N     P=0.720      P=0.024 *    | 
|POLY 3             |     P=0.009 **   P=0.570      P=0.466      P=0.007 **  |P=0.005 **   P=0.507N     P=0.748      P=0.048 *    | 
|POLY 1.5           |     P=0.018 *    P=0.612      P=0.552      P=0.025 *   |P=0.006 **   P=0.506N     P=0.753      P=0.053      | 
|POLY 6             |     P=0.004 **   P=0.507      P=0.350      P<0.001 **  |P=0.005 **   P=0.509N     P=0.741      P=0.042 *    | 
|LOGISTIC REGRESSION|     P=0.041 *    P=0.504      P=0.510      P=0.229     |P=0.004 **   (e)          P=0.720      P=0.040 *    | 
|COCH-ARM / FISHERS |     P=0.052      P=0.660N     P=0.660N     P=0.102     |P=0.007 **   P=0.504N     P=0.752N     P=0.057      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    5/60 (8%)    1/60 (2%)    2/60 (3%)   |1/60 (2%)    2/60 (3%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     1/53.85      5/44.71      1/34.77      2/22.99     |1/56.86      2/55.79      0/53.74      3/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         11.2%        2.9%         8.7%        |1.8%         3.6%         0.0%         5.6%         | 
|TERMINAL (d)       |     1/39 (3%)    2/18 (11%)   1/3 (33%)    0/0 (0%)    |1/47 (2%)    1/47 (2%)    0/39 (0%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      639          729 (T)      419         |729 (T)      705          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.017 *    P=0.160      P=0.185     |P=0.176      P=0.493      P=0.537N     P=0.189      | 
|POLY 3             |     P=0.237      P=0.066      P=0.654      P=0.254     |P=0.258      P=0.493      P=0.511N     P=0.283      | 
|POLY 1.5           |     P=0.397      P=0.081      P=0.703      P=0.354     |P=0.267      P=0.496      P=0.507N     P=0.294      | 
|POLY 6             |     P=0.095      P=0.049 *    P=0.577      P=0.165     |P=0.244      P=0.490      P=0.518N     P=0.265      | 
|LOGISTIC REGRESSION|     P=0.304      P=0.049 *    P=0.160      P=0.782N    |P=0.205      P=0.492      (e)          P=0.189      | 
|COCH-ARM / FISHERS |     P=0.506N     P=0.103      P=0.752N     P=0.500     |P=0.277      P=0.500      P=0.500N     P=0.309      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    5/60 (8%)    1/60 (2%)    2/60 (3%)   |1/60 (2%)    2/60 (3%)    0/60 (0%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     2/53.85      5/44.71      1/34.77      2/22.99     |1/56.86      2/55.79      0/53.74      4/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         11.2%        2.9%         8.7%        |1.8%         3.6%         0.0%         7.5%         | 
|TERMINAL (d)       |     2/39 (5%)    2/18 (11%)   1/3 (33%)    0/0 (0%)    |1/47 (2%)    1/47 (2%)    0/39 (0%)    4/33 (12%)   | 
|FIRST INCIDENCE    |     729 (T)      639          729 (T)      419         |729 (T)      705          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.007 **   P=0.042 *    P=0.256      P=0.185     |P=0.071      P=0.493      P=0.537N     P=0.090      | 
|POLY 3             |     P=0.390      P=0.149      P=0.644N     P=0.386     |P=0.126      P=0.493      P=0.511N     P=0.161      | 
|POLY 1.5           |     P=0.566      P=0.178      P=0.583N     P=0.525     |P=0.132      P=0.496      P=0.507N     P=0.170      | 
|POLY 6             |     P=0.195      P=0.115      P=0.697      P=0.244     |P=0.117      P=0.490      P=0.518N     P=0.146      | 
|LOGISTIC REGRESSION|     P=0.398      P=0.107      P=0.256      P=0.703N    |P=0.086      P=0.492      (e)          P=0.090      | 
|COCH-ARM / FISHERS |     P=0.341N     P=0.219      P=0.500N     P=0.691N    |P=0.139      P=0.500      P=0.500N     P=0.182      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/53.85      0/44.05      0/34.77      0/21.46     |0/56.86      0/55.69      1/53.82      2/53.98      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         1.9%         3.7%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          709          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049 *    (e)          P=0.461      P=0.221      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.057      (e)          P=0.489      P=0.226      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.059      (e)          P=0.494      P=0.232      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.054      (e)          P=0.483      P=0.217      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.066      (e)          P=0.496      P=0.247      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.061      (e)          P=0.500      P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    7/60 (12%)   10/60 (17%)  2/60 (3%)   |23/60 (38%)  47/60 (78%)  52/60 (87%)  56/60 (93%)  | 
|POLY-3 RATE (b)    |     0/53.85      7/44.88      10/38.12     2/22.15     |23/57.50     47/57.31     52/56.73     56/58.22     | 
|POLY-3 PERCENT (g) |     0.0%         15.6%        26.2%        9.0%        |40.0%        82.0%        91.7%        96.2%        | 
|TERMINAL (d)       |     0/39 (0%)    4/18 (22%)   1/3 (33%)    0/0 (0%)    |18/47 (38%)  39/47 (83%)  36/39 (92%)  33/33 (100%) | 
|FIRST INCIDENCE    |     ---          621          576          608         |620          505          525          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P=0.110     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.022 *    P=0.005 **   P<0.001 **   P=0.154     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P=0.077     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.003 **   P<0.001 **   P=0.030 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.250      P=0.006 **   P<0.001 **   P=0.248     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    7/60 (12%)   10/60 (17%)  2/60 (3%)   |23/60 (38%)  47/60 (78%)  52/60 (87%)  56/60 (93%)  | 
|POLY-3 RATE (b)    |     0/53.85      7/44.88      10/38.12     2/22.15     |23/57.50     47/57.31     52/56.73     56/58.22     | 
|POLY-3 PERCENT (g) |     0.0%         15.6%        26.2%        9.0%        |40.0%        82.0%        91.7%        96.2%        | 
|TERMINAL (d)       |     0/39 (0%)    4/18 (22%)   1/3 (33%)    0/0 (0%)    |18/47 (38%)  39/47 (83%)  36/39 (92%)  33/33 (100%) | 
|FIRST INCIDENCE    |     ---          621          576          608         |620          505          525          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P=0.110     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.022 *    P=0.005 **   P<0.001 **   P=0.154     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P=0.077     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.003 **   P<0.001 **   P=0.030 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.250      P=0.006 **   P<0.001 **   P=0.248     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    7/60 (12%)   10/60 (17%)  2/60 (3%)   |23/60 (38%)  47/60 (78%)  52/60 (87%)  57/60 (95%)  | 
|POLY-3 RATE (b)    |     0/53.85      7/44.88      10/38.12     2/22.15     |23/57.50     47/57.31     52/56.73     57/58.70     | 
|POLY-3 PERCENT (g) |     0.0%         15.6%        26.2%        9.0%        |40.0%        82.0%        91.7%        97.1%        | 
|TERMINAL (d)       |     0/39 (0%)    4/18 (22%)   1/3 (33%)    0/0 (0%)    |18/47 (38%)  39/47 (83%)  36/39 (92%)  33/33 (100%) | 
|FIRST INCIDENCE    |     ---          621          576          608         |620          505          525          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P=0.110     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.022 *    P=0.005 **   P<0.001 **   P=0.154     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P=0.077     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.003 **   P<0.001 **   P=0.030 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.250      P=0.006 **   P<0.001 **   P=0.248     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/53.85      1/44.07      0/34.77      0/21.46     |0/56.86      0/55.69      0/53.74      2/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         3.8%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     ---          726          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.515      P=0.372      (e)          (e)         |P=0.031 *    (e)          (e)          P=0.165      | 
|POLY 3             |     P=0.710      P=0.460      (e)          (e)         |P=0.050      (e)          (e)          P=0.224      | 
|POLY 1.5           |     P=0.651N     P=0.478      (e)          (e)         |P=0.051      (e)          (e)          P=0.231      | 
|POLY 6             |     P=0.619      P=0.435      (e)          (e)         |P=0.048 *    (e)          (e)          P=0.213      | 
|LOGISTIC REGRESSION|     P=0.559      P=0.376      (e)          (e)         |(e)          (e)          (e)          P=0.165      | 
|COCH-ARM / FISHERS |     P=0.517N     P=0.500      (e)          (e)         |P=0.053      (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/59 (19%)  9/60 (15%)   3/58 (5%)    9/59 (15%)  |19/59 (32%)  32/60 (53%)  26/60 (43%)  20/60 (33%)  | 
|POLY-3 RATE (b)    |     11/55.19     9/45.97      3/33.77      9/26.33     |19/56.21     32/57.45     26/54.81     20/55.23     | 
|POLY-3 PERCENT (g) |     19.9%        19.6%        8.9%         34.2%       |33.8%        55.7%        47.4%        36.2%        | 
|TERMINAL (d)       |     6/39 (15%)   3/18 (17%)   1/3 (33%)    0/0 (0%)    |16/46 (35%)  25/47 (53%)  19/39 (49%)  10/33 (30%)  | 
|FIRST INCIDENCE    |     441          569          621          391         |691          531          636          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.296      P=0.525      P<0.001 **  |P=0.147      P=0.020 *    P=0.044 *    P=0.156      | 
|POLY 3             |     P=0.390      P=0.581N     P=0.149N     P=0.155     |P=0.484N     P=0.014 *    P=0.100      P=0.473      | 
|POLY 1.5           |     P=0.471N     P=0.497N     P=0.072N     P=0.401     |P=0.439N     P=0.014 *    P=0.116      P=0.500      | 
|POLY 6             |     P=0.153      P=0.501      P=0.324N     P=0.030 *   |P=0.494      P=0.014 *    P=0.083      P=0.425      | 
|LOGISTIC REGRESSION|     P=0.455N     P=0.345N     P=0.055N     P=0.367N    |P=0.511N     P=0.013 *    P=0.075      P=0.446      | 
|COCH-ARM / FISHERS |     P=0.209N     P=0.387N     P=0.023N*    P=0.403N    |P=0.396N     P=0.016 *    P=0.144      P=0.526      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/59 (0%)    0/60 (0%)    0/60 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/53.85      0/43.44      0/34.77      0/21.46     |                                                    | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/39 (5%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403N     P=0.420N     P=0.840N     P=1.000N    |                                                    | 
|POLY 3             |     P=0.104N     P=0.288N     P=0.345N     P=0.463N    |                                                    | 
|POLY 1.5           |     P=0.080N     P=0.267N     P=0.295N     P=0.355N    |                                                    | 
|POLY 6             |     P=0.151N     P=0.321N     P=0.423N     P=0.593N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.403N     (e)          (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.067N     P=0.252N     P=0.248N     P=0.248N    |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    1/60 (2%)   |0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.85      0/44.05      0/34.77      1/21.88     |0/56.86      1/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         0.0%         0.0%         4.6%        |0.0%         1.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          608         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232      P=0.420N     P=0.840N     P=0.068     |P=0.573N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.382N     P=0.285N     P=0.345N     P=0.654     |P=0.528N     P=0.496      (e)          (e)          | 
|POLY 1.5           |     P=0.362N     P=0.263N     P=0.295N     P=0.652N    |P=0.523N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.379N     P=0.319N     P=0.423N     P=0.492     |P=0.535N     P=0.494      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.548      (e)          (e)          P=0.517     |(e)          P=0.500      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.339N     P=0.248N     P=0.248N     P=0.500N    |P=0.517N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/60 (12%)   3/60 (5%)    1/60 (2%)    1/60 (2%)   |0/60 (0%)    1/60 (2%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     7/54.46      3/44.62      1/35.30      1/21.88     |0/56.86      1/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     12.9%        6.7%         2.8%         4.6%        |0.0%         1.8%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/39 (13%)   1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     537          616          564          608         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.487      P=0.497N     P=0.592N     P=0.390     |P=0.573N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.053N     P=0.252N     P=0.114N     P=0.291N    |P=0.528N     P=0.496      (e)          (e)          | 
|POLY 1.5           |     P=0.022N*    P=0.208N     P=0.068N     P=0.126N    |P=0.523N     P=0.498      (e)          (e)          | 
|POLY 6             |     P=0.142N     P=0.323N     P=0.217N     P=0.560N    |P=0.535N     P=0.494      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.087N     P=0.236N     P=0.086N     P=0.609N    |(e)          P=0.500      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.007N**   P=0.161N     P=0.031N*    P=0.031N*   |P=0.517N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    46/60 (77%)  52/60 (87%)  59/60 (98%) |3/60 (5%)    3/60 (5%)    18/60 (30%)  20/60 (33%)  | 
|POLY-3 RATE (b)    |     5/54.01      46/54.11     52/54.03     59/59.12    |3/56.86      3/55.69      18/55.07     20/54.21     | 
|POLY-3 PERCENT (g) |     9.3%         85.0%        96.2%        99.8%       |5.3%         5.4%         32.7%        36.9%        | 
|TERMINAL (d)       |     3/39 (8%)    15/18 (83%)  3/3 (100%)   0/0 (0%)    |3/47 (6%)    3/47 (6%)    15/39 (39%)  14/33 (42%)  | 
|FIRST INCIDENCE    |     705          465          432          391         |729 (T)      729 (T)      432          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.663      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.652      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.656      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.647      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.663      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.660N     P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    47/60 (78%)  55/60 (92%)  59/60 (98%) |3/60 (5%)    3/60 (5%)    21/60 (35%)  22/60 (37%)  | 
|POLY-3 RATE (b)    |     5/54.01      47/54.49     55/55.72     59/59.12    |3/56.86      3/55.69      21/55.86     22/54.21     | 
|POLY-3 PERCENT (g) |     9.3%         86.3%        98.7%        99.8%       |5.3%         5.4%         37.6%        40.6%        | 
|TERMINAL (d)       |     3/39 (8%)    15/18 (83%)  3/3 (100%)   0/0 (0%)    |3/47 (6%)    3/47 (6%)    16/39 (41%)  16/33 (49%)  | 
|FIRST INCIDENCE    |     705          465          384          391         |729 (T)      729 (T)      432          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.663      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.652      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.656      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.647      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.663      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.660N     P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    7/60 (12%)   17/60 (28%)  20/60 (33%) |0/60 (0%)    0/60 (0%)    4/60 (7%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     0/53.85      7/45.87      17/40.23     20/33.65    |0/56.86      0/55.69      4/54.54      3/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         15.3%        42.3%        59.4%       |0.0%         0.0%         7.3%         5.6%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    2/39 (5%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     ---          569          384          439         |---          ---          569          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P=0.011 *    (e)          P=0.052      P=0.067      | 
|POLY 3             |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P=0.018 *    (e)          P=0.056      P=0.109      | 
|POLY 1.5           |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P=0.020 *    (e)          P=0.058      P=0.114      | 
|POLY 6             |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P=0.015 *    (e)          P=0.054      P=0.100      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P=0.024 *    (e)          P=0.074      P=0.067      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P=0.023 *    (e)          P=0.059      P=0.122      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.40      0/34.77      0/21.46     |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          632          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443      P=0.127      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.622      P=0.198      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.564N     P=0.215      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.430      P=0.175      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.702      P=0.211      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.382N     P=0.248      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    3/60 (5%)    1/60 (2%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     5/54.46      3/44.62      1/35.30      0/21.46     |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     9.2%         6.7%         2.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/39 (8%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     537          616          564          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.464N     P=0.612      P=0.661N     P=0.699N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.079N     P=0.470N     P=0.238N     P=0.218N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.029N*    P=0.419N     P=0.170N     P=0.101N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.240N     P=0.543N     P=0.358N     P=0.427N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.043N*    P=0.412N     P=0.141N     P=0.234N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.008N**   P=0.359N     P=0.103N     P=0.029N*   |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Lipoma                                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    4/60 (7%)    13/60 (22%)  13/60 (22%) |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     0/53.85      4/44.88      13/39.45     13/29.03    |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     0.0%         8.9%         33.0%        44.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          569          502          414         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.020 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.041 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.049 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.032 *    P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.057      P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.059      P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     55/60 (92%)  53/60 (88%)  51/60 (85%)  46/60 (77%) |                                                    | 
|POLY-3 RATE (b)    |     55/58.31     53/56.59     51/52.86     46/49.88    |                                                    | 
|POLY-3 PERCENT (g) |     94.3%        93.7%        96.5%        92.2%       |                                                    | 
|TERMINAL (d)       |     38/39 (97%)  18/18 (100%) 3/3 (100%)   0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     533          465          483          404         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |                                                    | 
|POLY 3             |     P=0.453N     P=0.610N     P=0.457      P=0.475N    |                                                    | 
|POLY 1.5           |     P=0.113N     P=0.503N     P=0.638N     P=0.146N    |                                                    | 
|POLY 6             |     P=0.234      P=0.646      P=0.271      P=0.541     |                                                    | 
|LOGISTIC REGRESSION|     P=0.021 *    P=0.433      P=0.049 *    P=0.141     |                                                    | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.381N     P=0.197N     P=0.022N*   |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/59 (17%)  6/60 (10%)   0/60 (0%)    1/60 (2%)   |9/60 (15%)   6/60 (10%)   3/60 (5%)    5/60 (8%)    | 
|POLY-3 RATE (b)    |     10/53.92     6/44.05      0/34.77      1/22.29     |9/56.86      6/56.38      3/55.36      5/53.82      | 
|POLY-3 PERCENT (g) |     18.6%        13.6%        0.0%         4.5%        |15.8%        10.6%        5.4%         9.3%         | 
|TERMINAL (d)       |     6/38 (16%)   6/18 (33%)   0/3 (0%)     0/0 (0%)    |9/47 (19%)   5/47 (11%)   0/39 (0%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     533          729 (T)      ---          404         |729 (T)      495          370          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.571N     P=0.480      P=0.183N     P=0.652     |P=0.220N     P=0.289N     P=0.109N     P=0.410N     | 
|POLY 3             |     P=0.006N**   P=0.352N     P=0.010N*    P=0.147N    |P=0.109N     P=0.296N     P=0.068N     P=0.227N     | 
|POLY 1.5           |     P<0.001N**   P=0.278N     P=0.004N**   P=0.037N*   |P=0.103N     P=0.294N     P=0.066N     P=0.212N     | 
|POLY 6             |     P=0.044N*    P=0.474N     P=0.040N*    P=0.438N    |P=0.121N     P=0.300N     P=0.073N     P=0.255N     | 
|LOGISTIC REGRESSION|     P=0.033N*    P=0.466N     P=0.010N*    P=0.056N    |P=0.080N     P=0.296N     P=0.046N*    P=0.268N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.200N     P<0.001N**   P=0.004N**  |P=0.096N     P=0.291N     P=0.063N     P=0.197N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/59 (0%)    4/60 (7%)    0/60 (0%)    1/60 (2%)   |1/60 (2%)    3/60 (5%)    3/60 (5%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/52.85      4/44.20      0/34.77      1/21.81     |1/56.86      3/55.69      3/53.74      1/53.42      | 
|POLY-3 PERCENT (g) |     0.0%         9.1%         0.0%         4.6%        |1.8%         5.4%         5.6%         1.9%         | 
|TERMINAL (d)       |     0/38 (0%)    3/18 (17%)   0/3 (0%)     0/0 (0%)    |1/47 (2%)    3/47 (6%)    3/39 (8%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          691          ---          632         |729 (T)      729 (T)      729 (T)      708          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.009 **   (e)          P=0.046 *   |P=0.446      P=0.306      P=0.241      P=0.693      | 
|POLY 3             |     P=0.323      P=0.042 *    (e)          P=0.350     |P=0.556      P=0.299      P=0.286      P=0.746      | 
|POLY 1.5           |     P=0.477      P=0.050      (e)          P=0.414     |P=0.567N     P=0.302      P=0.294      P=0.753      | 
|POLY 6             |     P=0.157      P=0.031 *    (e)          P=0.285     |P=0.523      P=0.295      P=0.275      P=0.735      | 
|LOGISTIC REGRESSION|     P=0.053      P=0.017 *    (e)          P=0.349     |P=0.479      P=0.306      P=0.241      P=0.741      | 
|COCH-ARM / FISHERS |     P=0.503N     P=0.061      (e)          P=0.504     |P=0.548N     P=0.309      P=0.309      P=0.752N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/59 (17%)  10/60 (17%)  0/60 (0%)    2/60 (3%)   |10/60 (17%)  9/60 (15%)   6/60 (10%)   6/60 (10%)   | 
|POLY-3 RATE (b)    |     10/53.92     10/44.20     0/34.77      2/22.64     |10/56.86     9/56.38      6/55.36      6/53.90      | 
|POLY-3 PERCENT (g) |     18.6%        22.6%        0.0%         8.8%        |17.6%        16.0%        10.8%        11.1%        | 
|TERMINAL (d)       |     6/38 (16%)   9/18 (50%)   0/3 (0%)     0/0 (0%)    |10/47 (21%)  8/47 (17%)   3/39 (8%)    3/33 (9%)    | 
|FIRST INCIDENCE    |     533          691          ---          404         |729 (T)      495          370          663          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103      P=0.072      P=0.183N     P=0.177     |P=0.305N     P=0.499N     P=0.323N     P=0.447N     | 
|POLY 3             |     P=0.029N*    P=0.403      P=0.010N*    P=0.269N    |P=0.142N     P=0.508N     P=0.226N     P=0.244N     | 
|POLY 1.5           |     P=0.005N**   P=0.498      P=0.004N**   P=0.090N    |P=0.131N     P=0.504N     P=0.219N     P=0.227N     | 
|POLY 6             |     P=0.206N     P=0.273      P=0.040N*    P=0.598N    |P=0.162N     P=0.513N     P=0.238N     P=0.273N     | 
|LOGISTIC REGRESSION|     P=0.242N     P=0.244      P=0.010N*    P=0.227N    |P=0.111N     P=0.513N     P=0.186N     P=0.290N     | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.580N     P<0.001N**   P=0.014N*   |P=0.120N     P=0.500N     P=0.211N     P=0.211N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/59 (2%)    1/60 (2%)    1/60 (2%)    1/60 (2%)   |0/60 (0%)    0/60 (0%)    2/60 (3%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     1/52.85      1/44.14      1/34.86      1/22.11     |0/56.86      0/55.69      2/54.19      1/53.41      | 
|POLY-3 PERCENT (g) |     1.9%         2.3%         2.9%         4.5%        |0.0%         0.0%         3.7%         1.9%         | 
|TERMINAL (d)       |     1/38 (3%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      707          706          512         |---          ---          597          709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    P=0.608      P=0.270      P=0.372     |P=0.129      (e)          P=0.212      P=0.425      | 
|POLY 3             |     P=0.418      P=0.719      P=0.659      P=0.547     |P=0.154      (e)          P=0.227      P=0.488      | 
|POLY 1.5           |     P=0.487      P=0.740      P=0.708      P=0.652     |P=0.162      (e)          P=0.232      P=0.494      | 
|POLY 6             |     P=0.364      P=0.686      P=0.583      P=0.420     |P=0.141      (e)          P=0.221      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.269      P=0.660      P=0.440      P=0.831     |P=0.179      (e)          P=0.262      P=0.495      | 
|COCH-ARM / FISHERS |     P=0.597N     P=0.748N     P=0.748N     P=0.748N    |P=0.170      (e)          P=0.248      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Papilloma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    2/60 (3%)    1/60 (2%)    0/59 (0%)   |0/60 (0%)    0/59 (0%)    1/60 (2%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     1/53.85      2/44.05      1/35.04      0/20.74     |0/56.86      0/54.87      1/53.74      1/53.33      | 
|POLY-3 PERCENT (g) |     1.9%         4.5%         2.9%         0.0%        |0.0%         0.0%         1.9%         1.9%         | 
|TERMINAL (d)       |     1/39 (3%)    2/18 (11%)   0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      656          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.125      P=0.242      P=0.392      P=1.000N    |P=0.131      (e)          P=0.463      P=0.429      | 
|POLY 3             |     P=0.630      P=0.431      P=0.656      P=0.658N    |P=0.174      (e)          P=0.489      P=0.487      | 
|POLY 1.5           |     P=0.440N     P=0.462      P=0.704      P=0.594N    |P=0.180      (e)          P=0.493      P=0.493      | 
|POLY 6             |     P=0.424      P=0.387      P=0.581      P=0.721N    |P=0.163      (e)          P=0.482      P=0.477      | 
|LOGISTIC REGRESSION|     P=0.324      P=0.242      P=0.633      (e)         |(e)          (e)          P=0.463      P=0.429      | 
|COCH-ARM / FISHERS |     P=0.252N     P=0.500      P=0.752N     P=0.504N    |P=0.186      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |11/60 (18%)  7/60 (12%)   15/60 (25%)  16/60 (27%)  | 
|POLY-3 RATE (b)    |                                                        |11/56.86     7/56.18      15/54.46     16/54.81     | 
|POLY-3 PERCENT (g) |                                                        |19.3%        12.5%        27.5%        29.2%        | 
|TERMINAL (d)       |                                                        |11/47 (23%)  6/47 (13%)   13/39 (33%)  9/33 (27%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      582          523          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.006 **   P=0.221N     P=0.114      P=0.041 *    | 
|POLY 3             |                                                        |P=0.043 *    P=0.229N     P=0.212      P=0.159      | 
|POLY 1.5           |                                                        |P=0.049 *    P=0.226N     P=0.229      P=0.175      | 
|POLY 6             |                                                        |P=0.034 *    P=0.232N     P=0.190      P=0.135      | 
|LOGISTIC REGRESSION|                                                        |P=0.040 *    P=0.237N     P=0.183      P=0.143      | 
|COCH-ARM / FISHERS |                                                        |P=0.058      P=0.222N     P=0.253      P=0.191      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |11/60 (18%)  8/60 (13%)   15/60 (25%)  17/60 (28%)  | 
|POLY-3 RATE (b)    |                                                        |11/56.86     8/56.18      15/54.46     17/54.81     | 
|POLY-3 PERCENT (g) |                                                        |19.3%        14.2%        27.5%        31.0%        | 
|TERMINAL (d)       |                                                        |11/47 (23%)  7/47 (15%)   13/39 (33%)  10/33 (30%)  | 
|FIRST INCIDENCE    |                                                        |729 (T)      582          523          586          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.004 **   P=0.308N     P=0.114      P=0.024 *    | 
|POLY 3             |                                                        |P=0.032 *    P=0.318N     P=0.212      P=0.113      | 
|POLY 1.5           |                                                        |P=0.038 *    P=0.314N     P=0.229      P=0.126      | 
|POLY 6             |                                                        |P=0.025 *    P=0.322N     P=0.190      P=0.093      | 
|LOGISTIC REGRESSION|                                                        |P=0.029 *    P=0.329N     P=0.183      P=0.097      | 
|COCH-ARM / FISHERS |                                                        |P=0.045 *    P=0.309N     P=0.253      P=0.140      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    2/60 (3%)   |1/60 (2%)    1/60 (2%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.73      0/34.77      2/22.99     |1/56.90      1/55.69      0/53.74      2/53.68      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         8.7%        |1.8%         1.8%         0.0%         3.7%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    1/47 (2%)    0/39 (0%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     ---          534          ---          359         |719          729 (T)      ---          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058      P=0.168      (e)          P=0.171     |P=0.316      P=0.751      P=0.554N     P=0.411      | 
|POLY 3             |     P=0.142      P=0.199      (e)          P=0.113     |P=0.384      P=0.756      P=0.511N     P=0.480      | 
|POLY 1.5           |     P=0.172      P=0.216      (e)          P=0.156     |P=0.392      P=0.758      P=0.507N     P=0.490      | 
|POLY 6             |     P=0.131      P=0.177      (e)          P=0.079     |P=0.373      P=0.753      P=0.518N     P=0.463      | 
|LOGISTIC REGRESSION|     P=0.570      P=0.307      (e)          P=0.913     |P=0.399      P=0.755      P=0.514N     P=0.514      | 
|COCH-ARM / FISHERS |     P=0.248      P=0.248      (e)          P=0.248     |P=0.399      P=0.752N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Zymbal's Gland                                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    2/60 (3%)   |2/60 (3%)    1/60 (2%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     0/53.85      2/44.73      0/34.77      2/22.99     |2/56.90      1/55.69      0/53.74      3/53.68      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         8.7%        |3.5%         1.8%         0.0%         5.6%         | 
|TERMINAL (d)       |     0/39 (0%)    0/18 (0%)    0/3 (0%)     0/0 (0%)    |1/47 (2%)    1/47 (2%)    0/39 (0%)    2/33 (6%)    | 
|FIRST INCIDENCE    |     ---          534          ---          359         |719          729 (T)      ---          632          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058      P=0.168      (e)          P=0.171     |P=0.293      P=0.509N     P=0.291N     P=0.369      | 
|POLY 3             |     P=0.142      P=0.199      (e)          P=0.113     |P=0.388      P=0.507N     P=0.251N     P=0.474      | 
|POLY 1.5           |     P=0.172      P=0.216      (e)          P=0.156     |P=0.396      P=0.504N     P=0.245N     P=0.487      | 
|POLY 6             |     P=0.131      P=0.177      (e)          P=0.079     |P=0.377      P=0.511N     P=0.258N     P=0.452      | 
|LOGISTIC REGRESSION|     P=0.570      P=0.307      (e)          P=0.913     |P=0.387      P=0.513N     P=0.262N     P=0.492      | 
|COCH-ARM / FISHERS |     P=0.248      P=0.248      (e)          P=0.248     |P=0.404      P=0.500N     P=0.248N     P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    3/60 (5%)    0/60 (0%)    2/60 (3%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/53.85      3/44.73      0/34.77      2/22.90     |0/56.86      0/55.69      0/53.74      2/53.76      | 
|POLY-3 PERCENT (g) |     0.0%         6.7%         0.0%         8.7%        |0.0%         0.0%         0.0%         3.7%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     ---          632          ---          439         |---          ---          ---          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.049 *    (e)          P=0.151     |P=0.045 *    (e)          (e)          P=0.208      | 
|POLY 3             |     P=0.158      P=0.090      (e)          P=0.112     |P=0.050      (e)          (e)          P=0.225      | 
|POLY 1.5           |     P=0.220      P=0.102      (e)          P=0.156     |P=0.051      (e)          (e)          P=0.231      | 
|POLY 6             |     P=0.107      P=0.075      (e)          P=0.079     |P=0.048 *    (e)          (e)          P=0.216      | 
|LOGISTIC REGRESSION|     P=0.431      P=0.116      (e)          P=0.756     |P=0.056      (e)          (e)          P=0.253      | 
|COCH-ARM / FISHERS |     P=0.345      P=0.122      (e)          P=0.248     |P=0.053      (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    3/60 (5%)    1/60 (2%)    2/60 (3%)   |0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     1/53.85      3/44.73      1/34.83      2/22.90     |0/56.86      0/55.69      1/53.74      2/53.76      | 
|POLY-3 PERCENT (g) |     1.9%         6.7%         2.9%         8.7%        |0.0%         0.0%         1.9%         3.7%         | 
|TERMINAL (d)       |     1/39 (3%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    1/39 (3%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      632          714          439         |---          ---          729 (T)      636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.131      P=0.252      P=0.151     |P=0.045 *    (e)          P=0.463      P=0.208      | 
|POLY 3             |     P=0.232      P=0.243      P=0.654      P=0.254     |P=0.057      (e)          P=0.489      P=0.225      | 
|POLY 1.5           |     P=0.334      P=0.270      P=0.704      P=0.353     |P=0.059      (e)          P=0.493      P=0.231      | 
|POLY 6             |     P=0.144      P=0.208      P=0.578      P=0.165     |P=0.053      (e)          P=0.482      P=0.216      | 
|LOGISTIC REGRESSION|     P=0.363      P=0.266      P=0.378      P=0.803     |P=0.064      (e)          P=0.463      P=0.253      | 
|COCH-ARM / FISHERS |     P=0.506      P=0.309      P=0.752N     P=0.500     |P=0.061      (e)          P=0.500      P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    2/60 (3%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/54.45      2/44.58      0/34.77      0/21.46     |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     1.8%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/18 (6%)    0/3 (0%)     0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     537          567          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.479N     P=0.397      P=0.561N     P=0.699N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.432N     P=0.431      P=0.585N     P=0.655N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.276N     P=0.462      P=0.549N     P=0.591N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.686N     P=0.388      P=0.634N     P=0.718N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.095N     P=0.655      P=0.292N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.158N     P=0.500      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/60 (50%)  21/60 (35%)  3/60 (5%)    3/60 (5%)   |21/60 (35%)  6/60 (10%)   4/60 (7%)    5/60 (8%)    | 
|POLY-3 RATE (b)    |     30/57.49     21/49.12     3/35.21      3/23.66     |21/59.04     6/56.70      4/54.59      5/55.15      | 
|POLY-3 PERCENT (g) |     52.2%        42.8%        8.5%         12.7%       |35.6%        10.6%        7.3%         9.1%         | 
|TERMINAL (d)       |     16/39 (41%)  7/18 (39%)   0/3 (0%)     0/0 (0%)    |11/47 (23%)  3/47 (6%)    1/39 (3%)    1/33 (3%)    | 
|FIRST INCIDENCE    |     533          465          676          419         |453          429          523          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491N     P=0.264      P=0.184N     P=0.316     |P<0.001N**   P=0.003N**   P=0.002N**   P=0.008N**   | 
|POLY 3             |     P<0.001N**   P=0.214N     P<0.001N**   P=0.003N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|POLY 1.5           |     P<0.001N**   P=0.132N     P<0.001N**   P<0.001N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|POLY 6             |     P=0.002N**   P=0.387N     P<0.001N**   P=0.177N    |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.085N     P<0.001N**   P<0.001N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.070N     P<0.001N**   P<0.001N**  |P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    20/60 (33%)  29/60 (48%)  44/60 (73%) |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.85      20/49.25     29/46.48     44/50.51    |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         40.6%        62.4%        87.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    5/18 (28%)   1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      428          432          359         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    20/60 (33%)  29/60 (48%)  44/60 (73%) |0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/53.85      20/49.25     29/46.48     44/50.51    |0/56.86      0/55.69      0/53.74      0/53.33      | 
|POLY-3 PERCENT (g) |     3.7%         40.6%        62.4%        87.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    5/18 (28%)   1/3 (33%)    0/0 (0%)    |0/47 (0%)    0/47 (0%)    0/39 (0%)    0/33 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      428          432          359         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     60/60 (100%) 58/60 (97%)  55/60 (92%)  59/60 (98%) |47/60 (78%)  57/60 (95%)  59/60 (98%)  59/60 (98%)  | 
|POLY-3 RATE (b)    |     60/60.00     58/58.34     55/55.51     59/59.12    |47/57.65     57/59.20     59/59.48     59/59.30     | 
|POLY-3 PERCENT (g) |     100.0%       99.4%        99.1%        99.8%       |81.5%        96.3%        99.2%        99.5%        | 
|TERMINAL (d)       |     39/39 (100%) 18/18 (100%) 3/3 (100%)   0/0 (0%)    |41/47 (87%)  45/47 (96%)  39/39 (100%) 33/33 (100%) | 
|FIRST INCIDENCE    |     441          465          432          391         |620          495          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.032 *    P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.799N     P=0.996N     P=0.974N     P=1.000N    |P<0.001 **   P=0.008 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.424N     P=0.613N     P=0.195N     P=0.970N    |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=1.000N     P=1.000N     P=1.000N     P=1.000N    |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.003 **   (e)          (e)          (e)         |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.252N     P=0.248N     P=0.029N*    P=0.500N    |P<0.001 **   P=0.007 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                   O-NITROTOLUENE           
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/60 (62%)  47/60 (78%)  42/60 (70%)  51/60 (85%) |24/60 (40%)  16/60 (27%)  18/60 (30%)  20/60 (33%)  | 
|POLY-3 RATE (b)    |     37/58.10     47/56.24     42/51.38     51/54.25    |24/59.08     16/57.37     18/56.09     20/56.38     | 
|POLY-3 PERCENT (g) |     63.7%        83.6%        81.8%        94.0%       |40.6%        27.9%        32.1%        35.5%        | 
|TERMINAL (d)       |     21/39 (54%)  14/18 (78%)  2/3 (67%)    0/0 (0%)    |13/47 (28%)  12/47 (26%)  11/39 (28%)  10/33 (30%)  | 
|FIRST INCIDENCE    |     533          378          384          359         |453          429          523          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.327      P=0.124N     P=0.387N     P=0.438      | 
|POLY 3             |     P<0.001 **   P=0.010 *    P=0.023 *    P<0.001 **  |P=0.369N     P=0.104N     P=0.224N     P=0.353N     | 
|POLY 1.5           |     P<0.001 **   P=0.019 *    P=0.064      P<0.001 **  |P=0.340N     P=0.096N     P=0.200N     P=0.319N     | 
|POLY 6             |     P<0.001 **   P=0.004 **   P=0.005 **   P<0.001 **  |P=0.423N     P=0.120N     P=0.262N     P=0.416N     | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.052      P=0.129      P=0.139     |P=0.251N     P=0.075N     P=0.139N     P=0.210N     | 
|COCH-ARM / FISHERS |     P=0.009 **   P=0.036 *    P=0.221      P=0.003 **  |P=0.309N     P=0.087N     P=0.169N     P=0.285N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        625 PPM      1250 PPM     2000 PPM    |0 PPM        625 PPM      1250 PPM     2000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     60/60 (100%) 60/60 (100%) 57/60 (95%)  60/60 (100%)|54/60 (90%)  58/60 (97%)  60/60 (100%) 60/60 (100%) | 
|POLY-3 RATE (b)    |     60/60.00     60/60.00     57/57.21     60/60.00    |54/59.17     58/60.00     60/60.00     60/60.00     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       99.6%        100.0%      |91.3%        96.7%        100.0%       100.0%       | 
|TERMINAL (d)       |     39/39 (100%) 18/18 (100%) 3/3 (100%)   0/0 (0%)    |42/47 (89%)  45/47 (96%)  39/39 (100%) 33/33 (100%) | 
|FIRST INCIDENCE    |     441          378          384          359         |453          429          370          464          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   (e)         |P<0.001 **   P=0.268      P=0.009 **   P<0.001 **   | 
|POLY 3             |     P=1.000N     (e)          P=1.000N     (e)         |P=0.003 **   P=0.195      P=0.026 *    P=0.026 *    | 
|POLY 1.5           |     P=0.688N     (e)          P=0.669N     (e)         |P=0.002 **   P=0.173      P=0.021 *    P=0.021 *    | 
|POLY 6             |     P=1.000N     (e)          P=1.000N     (e)         |P=0.003 **   P=0.209      P=0.030 *    P=0.030 *    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.126      P=0.013 *    P=0.014 *    | 
|COCH-ARM / FISHERS |     P=0.357N     (e)          P=0.122N     (e)         |P<0.001 **   P=0.136      P=0.014 *    P=0.014 *    | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).