Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/6884

TDMS Study 05203-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                        RATS, FINAL#1; CONTROL + 2000 & 5000PPM STOP GROUPS                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 PPM                                                                         
                                       INCLUDE 009    2000 PPM(STOP)                                                                
                                       INCLUDE 010    5000 PPM(STOP)                                                                
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Degeneration Fatty                                                                           
                                       Hyperplasia Diffuse                                                                          
                                       Hyperplasia Focal                                                                            
                                       Hypertrophy Focal                                                                            
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Brain                                  Compression                                                                                  
Epididymis                             Atypia Cellular                                                                              
Heart                                  Cardiomyopathy                                                                               
                                       Thrombosis                                                                                   
Islets, Pancreatic                     Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Kidney                                 Cyst                                                                                         
                                       Hydronephrosis                                                                               
                                       Inflammation Chronic                                                                         
                                       Nephropathy                                                                                  
Kidney: Renal Tubule                   Pigmentation                                                                                 
Liver                                  Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Infiltration Cellular Mixed Cell                                                             
                                       Mixed Cell Focus                                                                             
                                       Necrosis Focal                                                                               
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Necrosis                                                                                     
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Congestion                                                                                   
                                       Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
                                       Pigmentation                                                                                 
Lymph Node, Mediastinal                Hemorrhage                                                                                   
                                       Pigmentation                                                                                 
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Lymph Node: Pancreatic                 Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Foreign Body                                                                                 
                                       Inflammation Chronic                                                                         
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 08                                                                                     TIME: 09:39:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 88-72-2         
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Pancreas                               Atrophy                                                                                      
Pancreas: Acinus                       Hyperplasia Focal                                                                            
Peritoneum: Mesothelium                Hyperplasia                                                                                  
Pituitary Gland: Pars Distalis         Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Cytoplasmic Alteration                                                                       
                                       Hyperplasia Focal                                                                            
Pituitary Gland: Pars Intermedia       Cyst                                                                                         
Preputial Gland                        Atrophy                                                                                      
                                       Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Prostate: Ventral                      Hyperplasia                                                                                  
Salivary Glands                        Atrophy                                                                                      
Spleen                                 Fibrosis                                                                                     
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Forestomach                   Edema                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
Testes: Germinal Epithelium            Atrophy                                                                                      
Testes: Interstitial Cell              Hyperplasia                                                                                  
Thymus                                 Cyst                                                                                         
Thyroid Gland                          Ultimobranchial Cyst                                                                         
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   O-NITROTOLUENE 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/60 (22%)      14/60 (23%)      9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        13/54.52         14/43.80         9/25.12                                                            | 
|POLY-3 PERCENT (g) |        23.8%            32.0%            35.8%                                                              | 
|TERMINAL (d)       |        9/39 (23%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              419              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.009 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.156          P=0.251          P=0.225                                                            | 
|POLY 1.5           |        P=0.443          P=0.350          P=0.523                                                            | 
|POLY 6             |        P=0.024 *        P=0.141          P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.505N         P=0.451          P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.194N         P=0.500          P=0.240N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/60 (27%)      14/60 (23%)      12/60 (20%)                                                        | 
|POLY-3 RATE (b)    |        16/54.85         14/42.46         12/26.34                                                           | 
|POLY-3 PERCENT (g) |        29.2%            33.0%            45.6%                                                              | 
|TERMINAL (d)       |        13/39 (33%)      2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              502              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.015 *        P<0.001 **                                                         | 
|POLY 3             |        P=0.124          P=0.428          P=0.134                                                            | 
|POLY 1.5           |        P=0.387          P=0.562          P=0.423                                                            | 
|POLY 6             |        P=0.018 *        P=0.265          P=0.020 *                                                          | 
|LOGISTIC REGRESSION|        P=0.133          P=0.428          P=0.171                                                            | 
|COCH-ARM / FISHERS |        P=0.233N         P=0.417N         P=0.259N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Diffuse                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.85                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.6%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        (e)              P=0.143                                                            | 
|POLY 3             |        P=0.084          (e)              P=0.106                                                            | 
|POLY 1.5           |        P=0.065          (e)              P=0.147                                                            | 
|POLY 6             |        P=0.173          (e)              P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.352          (e)              P=0.852                                                            | 
|COCH-ARM / FISHERS |        P=0.092          (e)              P=0.248                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       4/60 (7%)        6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        6/53.85          4/39.90          6/23.27                                                            | 
|POLY-3 PERCENT (g) |        11.1%            10.0%            25.8%                                                              | 
|TERMINAL (d)       |        6/39 (15%)       0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          531              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.282          P<0.001 **                                                         | 
|POLY 3             |        P=0.159          P=0.564N         P=0.132                                                            | 
|POLY 1.5           |        P=0.277          P=0.482N         P=0.298                                                            | 
|POLY 6             |        P=0.086          P=0.585          P=0.042 *                                                          | 
|LOGISTIC REGRESSION|        P=0.304          P=0.627N         P=0.393                                                            | 
|COCH-ARM / FISHERS |        P=0.542          P=0.372N         P=0.619N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        3/60 (5%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        3/54.09          3/39.00          2/20.56                                                            | 
|POLY-3 PERCENT (g) |        5.6%             7.7%             9.7%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              658              485                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.009 **       P=0.194          P=0.076                                                            | 
|POLY 3             |        P=0.374          P=0.505          P=0.459                                                            | 
|POLY 1.5           |        P=0.530          P=0.573          P=0.626                                                            | 
|POLY 6             |        P=0.237          P=0.410          P=0.294                                                            | 
|LOGISTIC REGRESSION|        P=0.305          P=0.397          P=0.682                                                            | 
|COCH-ARM / FISHERS |        P=0.419N         P=0.660N         P=0.500N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       3/60 (5%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        7/54.16          3/39.44          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        12.9%            7.6%             5.0%                                                               | 
|TERMINAL (d)       |        5/39 (13%)       0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              499              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.327          P=0.544          P=0.338                                                            | 
|POLY 3             |        P=0.203N         P=0.318N         P=0.328N                                                           | 
|POLY 1.5           |        P=0.084N         P=0.243N         P=0.146N                                                           | 
|POLY 6             |        P=0.430N         P=0.438N         P=0.579N                                                           | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.365N         P=0.744N                                                           | 
|COCH-ARM / FISHERS |        P=0.023N*        P=0.161N         P=0.031N*                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        37/60 (62%)      33/60 (55%)                                                        | 
|POLY-3 RATE (b)    |        2/53.85          37/52.90         33/41.18                                                           | 
|POLY-3 PERCENT (g) |        3.7%             69.9%            80.1%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        6/55.95          2/39.16          1/19.86                                                            | 
|POLY-3 PERCENT (g) |        10.7%            5.1%             5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              658              567                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.641          P=0.410N         P=0.692                                                            | 
|POLY 3             |        P=0.229N         P=0.282N         P=0.405N                                                           | 
|POLY 1.5           |        P=0.111N         P=0.212N         P=0.211N                                                           | 
|POLY 6             |        P=0.418N         P=0.391N         P=0.624                                                            | 
|LOGISTIC REGRESSION|        P=0.025N*        P=0.053N         P=0.016N*                                                          | 
|COCH-ARM / FISHERS |        P=0.040N*        P=0.136N         P=0.057N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/54.87          2/38.89          1/19.71                                                            | 
|POLY-3 PERCENT (g) |        5.5%             5.1%             5.1%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              658              621                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.194          P=0.549          P=0.395                                                            | 
|POLY 3             |        P=0.599N         P=0.650N         P=0.659N                                                           | 
|POLY 1.5           |        P=0.419N         P=0.588N         P=0.513N                                                           | 
|POLY 6             |        P=0.523          P=0.611          P=0.523                                                            | 
|LOGISTIC REGRESSION|        P=0.524N         P=0.493N         P=0.455N                                                           | 
|COCH-ARM / FISHERS |        P=0.240N         P=0.500N         P=0.309N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/60 (65%)      24/60 (40%)      28/58 (48%)                                                        | 
|POLY-3 RATE (b)    |        39/57.69         24/46.73         28/38.71                                                           | 
|POLY-3 PERCENT (g) |        67.6%            51.4%            72.3%                                                              | 
|TERMINAL (d)       |        25/39 (64%)      5/11 (46%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.056          P<0.001 **                                                         | 
|POLY 3             |        P=0.435          P=0.060N         P=0.389                                                            | 
|POLY 1.5           |        P=0.325N         P=0.022N*        P=0.375N                                                           | 
|POLY 6             |        P=0.106          P=0.184N         P=0.064                                                            | 
|LOGISTIC REGRESSION|        P=0.087N         P=0.025N*        P=0.029N*                                                          | 
|COCH-ARM / FISHERS |        P=0.070N         P=0.005N**       P=0.050N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/58 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.12          0/18.38                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.239          P=0.104          (e)                                                                | 
|POLY 3             |        P=0.350          P=0.175          (e)                                                                | 
|POLY 1.5           |        P=0.519          P=0.200          (e)                                                                | 
|POLY 6             |        P=0.167          P=0.146          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.604          P=0.196          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.622N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/60 (67%)      39/60 (65%)      46/60 (77%)                                                        | 
|POLY-3 RATE (b)    |        40/57.01         39/50.36         46/49.91                                                           | 
|POLY-3 PERCENT (g) |        70.2%            77.5%            92.2%                                                              | 
|TERMINAL (d)       |        27/39 (69%)      10/11 (91%)      0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              275              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.250          P=0.002 **                                                         | 
|POLY 1.5           |        P=0.010 *        P=0.414          P=0.013 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.094          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.003 **       P=0.244          P=0.022 *                                                          | 
|COCH-ARM / FISHERS |        P=0.121          P=0.500N         P=0.156                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          4/39.86          1/20.00                                                            | 
|POLY-3 PERCENT (g) |        1.9%             10.0%            5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          589              501                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.037 *        P=0.032 *        P=0.365                                                            | 
|POLY 3             |        P=0.191          P=0.104          P=0.522                                                            | 
|POLY 1.5           |        P=0.377          P=0.132          P=0.630                                                            | 
|POLY 6             |        P=0.062          P=0.074          P=0.407                                                            | 
|LOGISTIC REGRESSION|        P=0.509          P=0.148          P=0.806                                                            | 
|COCH-ARM / FISHERS |        P=0.540N         P=0.182          P=0.752N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        2/60 (3%)        10/60 (17%)                                                        | 
|POLY-3 RATE (b)    |        2/54.06          2/39.49          10/27.60                                                           | 
|POLY-3 PERCENT (g) |        3.7%             5.1%             36.2%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              537              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.424          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.575          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.627          P=0.002 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.501          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.313          P=0.696N         P=0.556N                                                           | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.691N         P=0.015 *                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        0/60 (0%)        11/60 (18%)                                                        | 
|POLY-3 RATE (b)    |        1/53.85          0/38.63          11/28.01                                                           | 
|POLY-3 PERCENT (g) |        1.9%             0.0%             39.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.750N         P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.565N         P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.537N         P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.601N         P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.043 *        (e)              P=0.508                                                            | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.002 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        1/60 (2%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          1/38.85          2/20.63                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.6%             9.7%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              670              464                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        P=0.349          P=0.086                                                            | 
|POLY 3             |        P=0.072          P=0.436          P=0.105                                                            | 
|POLY 1.5           |        P=0.084          P=0.463          P=0.146                                                            | 
|POLY 6             |        P=0.085          P=0.400          P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.183          P=0.469          P=0.449                                                            | 
|COCH-ARM / FISHERS |        P=0.161          P=0.500          P=0.248                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          3/21.15                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             14.2%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.004 **                                                         | 
|POLY 3             |        P=0.026 *        (e)              P=0.034 *                                                          | 
|POLY 1.5           |        P=0.019 *        (e)              P=0.056                                                            | 
|POLY 6             |        P=0.064          (e)              P=0.021 *                                                          | 
|LOGISTIC REGRESSION|        P=0.095          (e)              P=0.307                                                            | 
|COCH-ARM / FISHERS |        P=0.033 *        (e)              P=0.122                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/38.89          4/21.75                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             18.4%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              658              464                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.068          P=0.002 **                                                         | 
|POLY 3             |        P=0.007 **       P=0.174          P=0.011 *                                                          | 
|POLY 1.5           |        P=0.012 *        P=0.199          P=0.022 *                                                          | 
|POLY 6             |        P=0.006 **       P=0.145          P=0.006 **                                                         | 
|LOGISTIC REGRESSION|        P=0.020 *        P=0.132          P=0.096                                                            | 
|COCH-ARM / FISHERS |        P=0.043 *        P=0.248          P=0.059                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        56/60 (93%)      60/60 (100%)     60/60 (100%)                                                       | 
|POLY-3 RATE (b)    |        56/59.40         60/60.00         60/60.00                                                           | 
|POLY-3 PERCENT (g) |        94.3%            100.0%           100.0%                                                             | 
|TERMINAL (d)       |        37/39 (95%)      11/11 (100%)     0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.032 *        P=0.077          P=0.077                                                            | 
|POLY 1.5           |        P=0.028 *        P=0.068          P=0.068                                                            | 
|POLY 6             |        P=0.043 *        P=0.098          P=0.098                                                            | 
|LOGISTIC REGRESSION|        P=0.085          P=0.093          P=0.338                                                            | 
|COCH-ARM / FISHERS |        P=0.027 *        P=0.059          P=0.059                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/54.07          2/38.94          1/20.03                                                            | 
|POLY-3 PERCENT (g) |        5.6%             5.1%             5.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              658              485                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.155          P=0.430          P=0.404                                                            | 
|POLY 3             |        P=0.588N         P=0.643N         P=0.652N                                                           | 
|POLY 1.5           |        P=0.412N         P=0.584N         P=0.507N                                                           | 
|POLY 6             |        P=0.535          P=0.622          P=0.532                                                            | 
|LOGISTIC REGRESSION|        P=0.681          P=0.650          P=0.735N                                                           | 
|COCH-ARM / FISHERS |        P=0.240N         P=0.500N         P=0.309N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/54.15          2/40.12          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        1.9%             5.0%             5.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              420              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.355          P=0.414          P=0.336                                                            | 
|POLY 3             |        P=0.337          P=0.398          P=0.520                                                            | 
|POLY 1.5           |        P=0.454          P=0.441          P=0.629                                                            | 
|POLY 6             |        P=0.237          P=0.340          P=0.405                                                            | 
|LOGISTIC REGRESSION|        P=0.286N         P=0.691N         P=0.875                                                            | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.500          P=0.752N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/21.06                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.5%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.074          (e)              P=0.200                                                            | 
|POLY 3             |        P=0.083          (e)              P=0.106                                                            | 
|POLY 1.5           |        P=0.065          (e)              P=0.148                                                            | 
|POLY 6             |        P=0.170          (e)              P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.384          (e)              P=0.994                                                            | 
|COCH-ARM / FISHERS |        P=0.092          (e)              P=0.248                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        18/60 (30%)      6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        5/54.15          18/43.30         6/23.35                                                            | 
|POLY-3 PERCENT (g) |        9.2%             41.6%            25.7%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        5/11 (46%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              523              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.004 **       P<0.001 **       P=0.089                                                            | 
|POLY 1.5           |        P=0.086          P<0.001 **       P=0.213                                                            | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.028 *                                                          | 
|LOGISTIC REGRESSION|        P=0.131          P<0.001 **       P=0.486                                                            | 
|COCH-ARM / FISHERS |        P=0.493N         P=0.002 **       P=0.500                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          2/39.35          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        1.9%             5.1%             5.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          595              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.094          P=0.247          P=0.314                                                            | 
|POLY 3             |        P=0.335          P=0.394          P=0.521                                                            | 
|POLY 1.5           |        P=0.454          P=0.438          P=0.630                                                            | 
|POLY 6             |        P=0.234          P=0.336          P=0.406                                                            | 
|LOGISTIC REGRESSION|        P=0.538          P=0.480          P=0.715                                                            | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.500          P=0.752N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        3/60 (5%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          3/39.98          2/20.85                                                            | 
|POLY-3 PERCENT (g) |        0.0%             7.5%             9.6%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              502              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.042 *        P=0.054          P=0.151                                                            | 
|POLY 3             |        P=0.046 *        P=0.076          P=0.106                                                            | 
|POLY 1.5           |        P=0.096          P=0.092          P=0.147                                                            | 
|POLY 6             |        P=0.021 *        P=0.058          P=0.077                                                            | 
|LOGISTIC REGRESSION|        P=0.602          P=0.209          P=0.756                                                            | 
|COCH-ARM / FISHERS |        P=0.266          P=0.122          P=0.248                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        0/60 (0%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.94          0/38.63          3/21.43                                                            | 
|POLY-3 PERCENT (g) |        1.9%             0.0%             14.0%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        707              ---              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        P=0.701N         P=0.027 *                                                          | 
|POLY 3             |        P=0.114          P=0.565N         P=0.096                                                            | 
|POLY 1.5           |        P=0.105          P=0.537N         P=0.161                                                            | 
|POLY 6             |        P=0.180          P=0.602N         P=0.055                                                            | 
|LOGISTIC REGRESSION|        P=0.325          P=0.630N         P=0.615                                                            | 
|COCH-ARM / FISHERS |        P=0.153          P=0.500N         P=0.309                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/60 (63%)      31/60 (52%)      17/60 (28%)                                                        | 
|POLY-3 RATE (b)    |        38/54.87         31/47.22         17/30.44                                                           | 
|POLY-3 PERCENT (g) |        69.3%            65.7%            55.9%                                                              | 
|TERMINAL (d)       |        34/39 (87%)      8/11 (73%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              260              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.133N         P=0.425N         P=0.147N                                                           | 
|POLY 1.5           |        P=0.009N**       P=0.277N         P=0.010N*                                                          | 
|POLY 6             |        P=0.482          P=0.559          P=0.526                                                            | 
|LOGISTIC REGRESSION|        P=0.374N         P=0.424          P=0.592N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.134N         P<0.001N**                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        29/60 (48%)      30/60 (50%)      34/60 (57%)                                                        | 
|POLY-3 RATE (b)    |        29/54.06         30/48.25         34/42.40                                                           | 
|POLY-3 PERCENT (g) |        53.6%            62.2%            80.2%                                                              | 
|TERMINAL (d)       |        26/39 (67%)      9/11 (82%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              370              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.002 **       P=0.240          P=0.003 **                                                         | 
|POLY 1.5           |        P=0.022 *        P=0.337          P=0.026 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.136          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.018 *        P=0.118          P=0.027 *                                                          | 
|COCH-ARM / FISHERS |        P=0.202          P=0.500          P=0.232                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        6/60 (10%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/53.85          6/39.38          3/20.96                                                            | 
|POLY-3 PERCENT (g) |        5.6%             15.2%            14.3%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          569              547                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.005 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.114          P=0.117          P=0.261                                                            | 
|POLY 1.5           |        P=0.284          P=0.164          P=0.418                                                            | 
|POLY 6             |        P=0.029 *        P=0.070          P=0.141                                                            | 
|LOGISTIC REGRESSION|        P=0.025 *        P=0.039 *        P=0.197                                                            | 
|COCH-ARM / FISHERS |        P=0.529N         P=0.245          P=0.660N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       15/60 (25%)      13/60 (22%)                                                        | 
|POLY-3 RATE (b)    |        7/53.98          15/42.08         13/26.74                                                           | 
|POLY-3 PERCENT (g) |        13.0%            35.7%            48.6%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              569              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.007 **       P<0.001 **                                                         | 
|POLY 1.5           |        P=0.006 **       P=0.017 *        P=0.010 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.004 **       P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P=0.139          P=0.049 *        P=0.110                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.46          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              523              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.459          P=0.144          (e)                                                                | 
|POLY 3             |        P=0.360          P=0.177          (e)                                                                | 
|POLY 1.5           |        P=0.529          P=0.201          (e)                                                                | 
|POLY 6             |        P=0.172          P=0.148          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.668N         P=0.316          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        11/60 (18%)      6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        0/53.85          11/43.80         6/22.67                                                            | 
|POLY-3 PERCENT (g) |        0.0%             25.1%            26.5%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              260              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P=0.003 **       P<0.001 **       P=0.003 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.422          P=0.013 *        P=0.011 *                                                          | 
|COCH-ARM / FISHERS |        P=0.090          P<0.001 **       P=0.014 *                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.85          2/39.41          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          499              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.623          P=0.362          P=1.000N                                                           | 
|POLY 3             |        P=0.542N         P=0.576          P=0.485N                                                           | 
|POLY 1.5           |        P=0.333N         P=0.628          P=0.373N                                                           | 
|POLY 6             |        P=0.578          P=0.501          P=0.603N                                                           | 
|LOGISTIC REGRESSION|        P=0.427N         P=0.677          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.173N         P=0.691N         P=0.248N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        10/60 (17%)      4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        5/54.30          10/41.36         4/21.85                                                            | 
|POLY-3 PERCENT (g) |        9.2%             24.2%            18.3%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              555              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.003 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.085          P=0.043 *        P=0.273                                                            | 
|POLY 1.5           |        P=0.304          P=0.072          P=0.473                                                            | 
|POLY 6             |        P=0.009 **       P=0.020 *        P=0.124                                                            | 
|LOGISTIC REGRESSION|        P=0.346          P=0.071          P=0.613                                                            | 
|COCH-ARM / FISHERS |        P=0.369N         P=0.135          P=0.500N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        15/60 (25%)      33/60 (55%)                                                        | 
|POLY-3 RATE (b)    |        1/53.85          15/45.26         33/40.91                                                           | 
|POLY-3 PERCENT (g) |        1.9%             33.1%            80.7%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          370              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/60 (8%)        12/60 (20%)      8/60 (13%)                                                         | 
|POLY-3 RATE (b)    |        5/53.85          12/42.23         8/24.64                                                            | 
|POLY-3 PERCENT (g) |        9.3%             28.4%            32.5%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          499              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.006 **       P=0.014 *        P=0.022 *                                                          | 
|POLY 1.5           |        P=0.047 *        P=0.026 *        P=0.075                                                            | 
|POLY 6             |        P<0.001 **       P=0.006 **       P=0.005 **                                                         | 
|LOGISTIC REGRESSION|        P=0.110          P=0.026 *        P=0.189                                                            | 
|COCH-ARM / FISHERS |        P=0.331          P=0.057          P=0.279                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        2/60 (3%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/54.55          2/39.14          3/21.22                                                            | 
|POLY-3 PERCENT (g) |        5.5%             5.1%             14.1%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              595              471                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.019 *        P=0.525          P=0.055                                                            | 
|POLY 3             |        P=0.278          P=0.645N         P=0.261                                                            | 
|POLY 1.5           |        P=0.372          P=0.585N         P=0.417                                                            | 
|POLY 6             |        P=0.222          P=0.620          P=0.142                                                            | 
|LOGISTIC REGRESSION|        P=0.551          P=0.507N         P=0.738N                                                           | 
|COCH-ARM / FISHERS |        P=0.581          P=0.500N         P=0.660N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        53/60 (88%)      6/60 (10%)       1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        53/58.86         6/39.55          1/20.18                                                            | 
|POLY-3 PERCENT (g) |        90.1%            15.2%            5.0%                                                               | 
|TERMINAL (d)       |        35/39 (90%)      3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              595              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002N**       P<0.001N**       P=0.361N                                                           | 
|POLY 3             |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|POLY 1.5           |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|POLY 6             |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|LOGISTIC REGRESSION|        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        9/60 (15%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.86          9/41.86          3/21.34                                                            | 
|POLY-3 PERCENT (g) |        1.9%             21.5%            14.1%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              420              417                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P=0.026 *                                                          | 
|POLY 3             |        P=0.012 *        P=0.002 **       P=0.096                                                            | 
|POLY 1.5           |        P=0.083          P=0.004 **       P=0.161                                                            | 
|POLY 6             |        P<0.001 **       P<0.001 **       P=0.055                                                            | 
|LOGISTIC REGRESSION|        P=0.450          P=0.016 *        P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.435          P=0.008 **       P=0.309                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/60 (7%)        1/60 (2%)        6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        4/54.62          1/39.26          6/24.22                                                            | 
|POLY-3 PERCENT (g) |        7.3%             2.6%             24.8%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              523              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.437N         P=0.008 **                                                         | 
|POLY 3             |        P=0.089          P=0.296N         P=0.059                                                            | 
|POLY 1.5           |        P=0.122          P=0.242N         P=0.146                                                            | 
|POLY 6             |        P=0.075          P=0.381N         P=0.018 *                                                          | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.133N         P=0.196N                                                           | 
|COCH-ARM / FISHERS |        P=0.232          P=0.182N         P=0.372                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/60 (7%)        0/60 (0%)        2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        4/54.70          0/38.63          2/20.94                                                            | 
|POLY-3 PERCENT (g) |        7.3%             0.0%             9.6%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              ---              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.381          P=0.213N         P=0.338                                                            | 
|POLY 3             |        P=0.452N         P=0.121N         P=0.550                                                            | 
|POLY 1.5           |        P=0.382N         P=0.091N         P=0.584N                                                           | 
|POLY 6             |        P=0.489N         P=0.174N         P=0.351                                                            | 
|LOGISTIC REGRESSION|        P=0.166N         P=0.056N         P=0.185N                                                           | 
|COCH-ARM / FISHERS |        P=0.307N         P=0.059N         P=0.340N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/38.63          1/20.24                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             4.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              729 (T)          316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.034 *        P=0.034 *        P=0.493                                                            | 
|POLY 3             |        P=0.149          P=0.173          P=0.338                                                            | 
|POLY 1.5           |        P=0.234          P=0.199          P=0.402                                                            | 
|POLY 6             |        P=0.088          P=0.143          P=0.281                                                            | 
|LOGISTIC REGRESSION|        P=0.455          P=0.034 *        (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.444          P=0.248          P=0.500                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        3/60 (5%)        4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        3/54.48          3/39.29          4/21.81                                                            | 
|POLY-3 PERCENT (g) |        5.5%             7.6%             18.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              534              362                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.262          P=0.015 *                                                          | 
|POLY 3             |        P=0.123          P=0.505          P=0.135                                                            | 
|POLY 1.5           |        P=0.207          P=0.573          P=0.255                                                            | 
|POLY 6             |        P=0.075          P=0.410          P=0.061                                                            | 
|LOGISTIC REGRESSION|        P=0.355          P=0.650          P=0.641                                                            | 
|COCH-ARM / FISHERS |        P=0.427          P=0.660N         P=0.500                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        25/60 (42%)      23/60 (38%)      15/60 (25%)                                                        | 
|POLY-3 RATE (b)    |        25/56.21         23/45.45         15/28.55                                                           | 
|POLY-3 PERCENT (g) |        44.5%            50.6%            52.5%                                                              | 
|TERMINAL (d)       |        16/39 (41%)      4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              419              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.258          P=0.336          P=0.328                                                            | 
|POLY 1.5           |        P=0.386N         P=0.491          P=0.405N                                                           | 
|POLY 6             |        P=0.028 *        P=0.177          P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.506          P=0.436          P=0.608                                                            | 
|COCH-ARM / FISHERS |        P=0.031N*        P=0.426N         P=0.040N*                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        15/60 (25%)      29/60 (48%)                                                        | 
|POLY-3 RATE (b)    |        2/53.86          15/42.70         29/39.41                                                           | 
|POLY-3 PERCENT (g) |        3.7%             35.1%            73.6%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/58 (3%)        1/58 (2%)        0/59 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/51.94          1/38.10          0/19.21                                                            | 
|POLY-3 PERCENT (g) |        3.9%             2.6%             0.0%                                                               | 
|TERMINAL (d)       |        2/38 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.765          P=0.651          P=1.000N                                                           | 
|POLY 3             |        P=0.392N         P=0.605N         P=0.479N                                                           | 
|POLY 1.5           |        P=0.251N         P=0.561N         P=0.367N                                                           | 
|POLY 6             |        P=0.602N         P=0.663N         P=0.600N                                                           | 
|LOGISTIC REGRESSION|        P=0.661N         P=0.700N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.158N         P=0.500N         P=0.244N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/58 (3%)        4/58 (7%)        3/59 (5%)                                                          | 
|POLY-3 RATE (b)    |        2/52.72          4/38.98          3/20.96                                                            | 
|POLY-3 PERCENT (g) |        3.8%             10.3%            14.3%                                                              | 
|TERMINAL (d)       |        1/38 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              502              453                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       P=0.095          P=0.050                                                            | 
|POLY 3             |        P=0.103          P=0.213          P=0.179                                                            | 
|POLY 1.5           |        P=0.209          P=0.262          P=0.294                                                            | 
|POLY 6             |        P=0.045 *        P=0.157          P=0.098                                                            | 
|LOGISTIC REGRESSION|        P=0.533          P=0.468          P=0.754N                                                           | 
|COCH-ARM / FISHERS |        P=0.476          P=0.340          P=0.508                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/58 (5%)        5/58 (9%)        3/59 (5%)                                                          | 
|POLY-3 RATE (b)    |        3/52.26          5/38.86          3/21.38                                                            | 
|POLY-3 PERCENT (g) |        5.7%             12.9%            14.0%                                                              | 
|TERMINAL (d)       |        2/38 (5%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              615              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.043 *        P=0.044 *                                                          | 
|POLY 3             |        P=0.158          P=0.212          P=0.275                                                            | 
|POLY 1.5           |        P=0.320          P=0.268          P=0.434                                                            | 
|POLY 6             |        P=0.058          P=0.149          P=0.149                                                            | 
|LOGISTIC REGRESSION|        P=0.410          P=0.208          P=0.693N                                                           | 
|COCH-ARM / FISHERS |        P=0.540N         P=0.358          P=0.652N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/58 (16%)       5/58 (9%)        5/59 (8%)                                                          | 
|POLY-3 RATE (b)    |        9/52.29          5/39.91          5/22.30                                                            | 
|POLY-3 PERCENT (g) |        17.2%            12.5%            22.4%                                                              | 
|TERMINAL (d)       |        6/38 (16%)       1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        673              370              453                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.381          P<0.001 **                                                         | 
|POLY 3             |        P=0.519          P=0.373N         P=0.431                                                            | 
|POLY 1.5           |        P=0.415N         P=0.291N         P=0.521N                                                           | 
|POLY 6             |        P=0.335          P=0.501N         P=0.181                                                            | 
|LOGISTIC REGRESSION|        P=0.480N         P=0.266N         P=0.456                                                            | 
|COCH-ARM / FISHERS |        P=0.169N         P=0.197N         P=0.187N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        4/60 (7%)        9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        2/54.21          4/40.70          9/24.48                                                            | 
|POLY-3 PERCENT (g) |        3.7%             9.8%             36.8%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              370              419                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.126          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.219          P<0.001 **                                                         | 
|POLY 1.5           |        P=0.002 **       P=0.267          P=0.003 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.162          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.032 *        P=0.595          P=0.009 **                                                         | 
|COCH-ARM / FISHERS |        P=0.015 *        P=0.340          P=0.027 *                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       13/60 (22%)      13/60 (22%)                                                        | 
|POLY-3 RATE (b)    |        6/54.93          13/43.19         13/28.14                                                           | 
|POLY-3 PERCENT (g) |        10.9%            30.1%            46.2%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              370              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.015 *        P<0.001 **                                                         | 
|POLY 1.5           |        P=0.004 **       P=0.030 *        P=0.006 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.006 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.173          P=0.102          P=0.283                                                            | 
|COCH-ARM / FISHERS |        P=0.080          P=0.066          P=0.066                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.37                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.8%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              419                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.028 *        (e)              P=0.094                                                            | 
|POLY 3             |        P=0.084          (e)              P=0.103                                                            | 
|POLY 1.5           |        P=0.064          (e)              P=0.144                                                            | 
|POLY 6             |        P=0.173          (e)              P=0.076                                                            | 
|LOGISTIC REGRESSION|        P=0.222          (e)              P=0.551                                                            | 
|COCH-ARM / FISHERS |        P=0.090          (e)              P=0.244                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        4/60 (7%)        4/59 (7%)                                                          | 
|POLY-3 RATE (b)    |        2/54.46          4/39.99          4/21.49                                                            | 
|POLY-3 PERCENT (g) |        3.7%             10.0%            18.6%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              499              502                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.103          P=0.014 *                                                          | 
|POLY 3             |        P=0.048 *        P=0.211          P=0.076                                                            | 
|POLY 1.5           |        P=0.104          P=0.261          P=0.148                                                            | 
|POLY 6             |        P=0.021 *        P=0.153          P=0.036 *                                                          | 
|LOGISTIC REGRESSION|        P=0.361          P=0.462          P=0.508                                                            | 
|COCH-ARM / FISHERS |        P=0.299          P=0.340          P=0.332                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        0/60 (0%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          0/38.63          2/20.12                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             9.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.010 *        (e)              P=0.036 *                                                          | 
|POLY 3             |        P=0.085          (e)              P=0.103                                                            | 
|POLY 1.5           |        P=0.064          (e)              P=0.143                                                            | 
|POLY 6             |        P=0.178          (e)              P=0.075                                                            | 
|LOGISTIC REGRESSION|        P=0.088          (e)              P=0.241                                                            | 
|COCH-ARM / FISHERS |        P=0.090          (e)              P=0.244                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/60 (5%)        0/60 (0%)        0/59 (0%)                                                          | 
|POLY-3 RATE (b)    |        3/54.18          0/38.63          0/19.00                                                            | 
|POLY-3 PERCENT (g) |        5.5%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.469N         P=0.352N         P=1.000N                                                           | 
|POLY 3             |        P=0.121N         P=0.192N         P=0.383N                                                           | 
|POLY 1.5           |        P=0.079N         P=0.158N         P=0.252N                                                           | 
|POLY 6             |        P=0.194N         P=0.250N         P=0.537N                                                           | 
|LOGISTIC REGRESSION|        P=0.220N         P=0.200N         P=0.643N                                                           | 
|COCH-ARM / FISHERS |        P=0.061N         P=0.122N         P=0.125N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/16 (0%)        0/18 (0%)        2/16 (13%)                                                         | 
|POLY-3 RATE (b)    |        0/13.11          0/10.69          2/6.39                                                             | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             31.3%                                                              | 
|TERMINAL (d)       |        0/4 (0%)         0/2 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              ---              581                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P<0.001 **                                                         | 
|POLY 3             |        P=0.055          (e)              P=0.105                                                            | 
|POLY 1.5           |        P=0.052          (e)              P=0.148                                                            | 
|POLY 6             |        P=0.066          (e)              P=0.071                                                            | 
|LOGISTIC REGRESSION|        P=0.028 *        (e)              P=0.081                                                            | 
|COCH-ARM / FISHERS |        P=0.083          (e)              P=0.242                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/57 (5%)        3/51 (6%)        1/50 (2%)                                                          | 
|POLY-3 RATE (b)    |        3/53.07          3/32.38          1/16.57                                                            | 
|POLY-3 PERCENT (g) |        5.7%             9.3%             6.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              658              567                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.151          P=0.269          P=0.560                                                            | 
|POLY 3             |        P=0.480          P=0.425          P=0.663                                                            | 
|POLY 1.5           |        P=0.531N         P=0.502          P=0.563N                                                           | 
|POLY 6             |        P=0.281          P=0.330          P=0.503                                                            | 
|LOGISTIC REGRESSION|        P=0.538N         P=0.638          P=0.218N                                                           | 
|COCH-ARM / FISHERS |        P=0.281N         P=0.606          P=0.360N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/57 (4%)        0/51 (0%)        0/50 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/51.98          0/32.12          0/16.04                                                            | 
|POLY-3 PERCENT (g) |        3.9%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.705N         P=0.544N         P=1.000N                                                           | 
|POLY 3             |        P=0.254N         P=0.355N         P=0.515N                                                           | 
|POLY 1.5           |        P=0.183N         P=0.314N         P=0.407N                                                           | 
|POLY 6             |        P=0.362N         P=0.413N         P=0.622N                                                           | 
|LOGISTIC REGRESSION|        P=0.693N         P=0.534N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.153N         P=0.276N         P=0.281N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/57 (11%)       1/51 (2%)        4/50 (8%)                                                          | 
|POLY-3 RATE (b)    |        6/53.30          1/32.12          4/19.18                                                            | 
|POLY-3 PERCENT (g) |        11.3%            3.1%             20.9%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              729 (T)          391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.076          P=0.324N         P=0.117                                                            | 
|POLY 3             |        P=0.454          P=0.189N         P=0.293                                                            | 
|POLY 1.5           |        P=0.555          P=0.133N         P=0.498                                                            | 
|POLY 6             |        P=0.371          P=0.284N         P=0.137                                                            | 
|LOGISTIC REGRESSION|        P=0.245N         P=0.078N         P=0.103N                                                           | 
|COCH-ARM / FISHERS |        P=0.439N         P=0.076N         P=0.457N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/16 (19%)       0/1 (0%)         0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        3/14.77          0/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        20.3%            0.0%             0.0%                                                               | 
|TERMINAL (d)       |        2/11 (18%)       0/1 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        586              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.525N         P=0.473N         P=0.889N                                                           | 
|POLY 3             |        P=0.448N         P=0.789N         P=0.623N                                                           | 
|POLY 1.5           |        P=0.375N         P=0.792N         P=0.575N                                                           | 
|POLY 6             |        P=0.588N         P=0.784N         P=0.690N                                                           | 
|LOGISTIC REGRESSION|        P=0.318N         P=0.849N         P=0.510N                                                           | 
|COCH-ARM / FISHERS |        P=0.357N         P=0.824N         P=0.578N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/16 (19%)       0/1 (0%)         0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        3/14.29          0/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        21.0%            0.0%             0.0%                                                               | 
|TERMINAL (d)       |        3/11 (27%)       0/1 (0%)         0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.876N         P=0.718N         P=1.000N                                                           | 
|POLY 3             |        P=0.440N         P=0.786N         P=0.617N                                                           | 
|POLY 1.5           |        P=0.370N         P=0.791N         P=0.571N                                                           | 
|POLY 6             |        P=0.577N         P=0.778N         P=0.686N                                                           | 
|LOGISTIC REGRESSION|        P=0.876N         (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.357N         P=0.824N         P=0.578N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/16 (81%)      1/1 (100%)       0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        13/16.00         1/1.00           0/1.72                                                             | 
|POLY-3 PERCENT (g) |        81.3%            100.0%           0.0%                                                               | 
|TERMINAL (d)       |        8/11 (73%)       1/1 (100%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              729 (T)          ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.249N         P=0.231N         P=0.681N                                                           | 
|POLY 3             |        P=0.108N         P=0.796          P=0.106N                                                           | 
|POLY 1.5           |        P=0.021N*        P=0.796          P=0.033N*                                                          | 
|POLY 6             |        P=0.513N         P=0.796          P=0.336N                                                           | 
|LOGISTIC REGRESSION|        P=0.021N*        P=0.231N         P=0.028N*                                                          | 
|COCH-ARM / FISHERS |        P=0.011N*        P=0.824          P=0.021N*                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       14/60 (23%)      5/60 (8%)                                                          | 
|POLY-3 RATE (b)    |        9/54.19          14/44.17         5/22.72                                                            | 
|POLY-3 PERCENT (g) |        16.6%            31.7%            22.0%                                                              | 
|TERMINAL (d)       |        6/39 (15%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        691              370              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.003 **                                                         | 
|POLY 3             |        P=0.162          P=0.062          P=0.420                                                            | 
|POLY 1.5           |        P=0.505          P=0.101          P=0.533N                                                           | 
|POLY 6             |        P=0.017 *        P=0.028 *        P=0.176                                                            | 
|LOGISTIC REGRESSION|        P=0.225N         P=0.234          P=0.692                                                            | 
|COCH-ARM / FISHERS |        P=0.139N         P=0.177          P=0.197N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       10/60 (17%)      2/60 (3%)                                                          | 
|POLY-3 RATE (b)    |        9/54.34          10/41.18         2/20.80                                                            | 
|POLY-3 PERCENT (g) |        16.6%            24.3%            9.6%                                                               | 
|TERMINAL (d)       |        6/39 (15%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        663              419              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.014 *        P=0.013 *        P=0.141                                                            | 
|POLY 3             |        P=0.574          P=0.251          P=0.371N                                                           | 
|POLY 1.5           |        P=0.208N         P=0.350          P=0.154N                                                           | 
|POLY 6             |        P=0.167          P=0.142          P=0.558                                                            | 
|LOGISTIC REGRESSION|        P=0.328N         P=0.272          P=0.330N                                                           | 
|COCH-ARM / FISHERS |        P=0.024N*        P=0.500          P=0.027N*                                                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       7/60 (12%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        6/54.35          7/40.25          3/21.51                                                            | 
|POLY-3 PERCENT (g) |        11.0%            17.4%            14.0%                                                              | 
|TERMINAL (d)       |        4/39 (10%)       2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              567              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.041 *        P=0.042 *                                                          | 
|POLY 3             |        P=0.338          P=0.283          P=0.513                                                            | 
|POLY 1.5           |        P=0.525N         P=0.370          P=0.529N                                                           | 
|POLY 6             |        P=0.114          P=0.184          P=0.281                                                            | 
|LOGISTIC REGRESSION|        P=0.569N         P=0.282          P=0.403N                                                           | 
|COCH-ARM / FISHERS |        P=0.192N         P=0.500          P=0.245N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/60 (3%)        0/60 (0%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.95          0/38.63          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        1/39 (3%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        705              ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.674N         P=0.515N         P=1.000N                                                           | 
|POLY 3             |        P=0.221N         P=0.319N         P=0.486N                                                           | 
|POLY 1.5           |        P=0.159N         P=0.282N         P=0.373N                                                           | 
|POLY 6             |        P=0.319N         P=0.374N         P=0.604N                                                           | 
|LOGISTIC REGRESSION|        P=0.530N         P=0.422N         P=0.975N                                                           | 
|COCH-ARM / FISHERS |        P=0.137N         P=0.248N         P=0.248N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/60 (18%)      11/60 (18%)      9/60 (15%)                                                         | 
|POLY-3 RATE (b)    |        11/54.55         11/41.89         9/24.84                                                            | 
|POLY-3 PERCENT (g) |        20.2%            26.3%            36.2%                                                              | 
|TERMINAL (d)       |        9/39 (23%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              420              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.019 *        P<0.001 **                                                         | 
|POLY 3             |        P=0.104          P=0.323          P=0.132                                                            | 
|POLY 1.5           |        P=0.313          P=0.434          P=0.365                                                            | 
|POLY 6             |        P=0.018 *        P=0.195          P=0.027 *                                                          | 
|LOGISTIC REGRESSION|        P=0.311          P=0.422          P=0.364                                                            | 
|COCH-ARM / FISHERS |        P=0.356N         P=0.593N         P=0.404N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/60 (2%)        6/60 (10%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        1/53.85          6/39.76          3/21.04                                                            | 
|POLY-3 PERCENT (g) |        1.9%             15.1%            14.3%                                                              | 
|TERMINAL (d)       |        1/39 (3%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          502              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P=0.002 **                                                         | 
|POLY 3             |        P=0.026 *        P=0.022 *        P=0.095                                                            | 
|POLY 1.5           |        P=0.096          P=0.034 *        P=0.160                                                            | 
|POLY 6             |        P=0.004 **       P=0.012 *        P=0.054                                                            | 
|LOGISTIC REGRESSION|        P=0.065          P=0.018 *        P=0.284                                                            | 
|COCH-ARM / FISHERS |        P=0.366          P=0.057          P=0.309                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Peritoneum: Mesothelium                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/3 (33%)        3/47 (6%)        0/54 (0%)                                                          | 
|POLY-3 RATE (b)    |        1/3.00           3/30.85          0/16.55                                                            | 
|POLY-3 PERCENT (g) |        33.3%            9.7%             0.0%                                                               | 
|TERMINAL (d)       |        1/3 (33%)        0/10 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          684              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.232          P=0.155          P=1.000N                                                           | 
|POLY 3             |        P=0.078N         P=0.371N         P=0.045N*                                                          | 
|POLY 1.5           |        P=0.029N*        P=0.327N         P=0.016N*                                                          | 
|POLY 6             |        P=0.269N         P=0.453N         P=0.266N                                                           | 
|LOGISTIC REGRESSION|        P=0.544N         P=0.559N         (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.019N*        P=0.226N         P=0.053N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/59 (5%)        4/57 (7%)        4/59 (7%)                                                          | 
|POLY-3 RATE (b)    |        3/53.10          4/38.39          4/22.02                                                            | 
|POLY-3 PERCENT (g) |        5.7%             10.4%            18.2%                                                              | 
|TERMINAL (d)       |        3/39 (8%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          592              391                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.088          P=0.019 *                                                          | 
|POLY 3             |        P=0.104          P=0.331          P=0.141                                                            | 
|POLY 1.5           |        P=0.201          P=0.393          P=0.262                                                            | 
|POLY 6             |        P=0.049 *        P=0.252          P=0.065                                                            | 
|LOGISTIC REGRESSION|        P=0.420          P=0.315          P=0.717                                                            | 
|COCH-ARM / FISHERS |        P=0.453          P=0.481          P=0.500                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/59 (3%)        3/57 (5%)        6/59 (10%)                                                         | 
|POLY-3 RATE (b)    |        2/53.10          3/38.82          6/22.92                                                            | 
|POLY-3 PERCENT (g) |        3.8%             7.7%             26.2%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          370              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.195          P<0.001 **                                                         | 
|POLY 3             |        P=0.012 *        P=0.362          P=0.013 *                                                          | 
|POLY 1.5           |        P=0.025 *        P=0.414          P=0.037 *                                                          | 
|POLY 6             |        P=0.007 **       P=0.292          P=0.004 **                                                         | 
|LOGISTIC REGRESSION|        P=0.237          P=0.623          P=0.197                                                            | 
|COCH-ARM / FISHERS |        P=0.093          P=0.484          P=0.136                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/59 (2%)        1/57 (2%)        42/59 (71%)                                                        | 
|POLY-3 RATE (b)    |        1/53.11          1/38.31          42/49.79                                                           | 
|POLY-3 PERCENT (g) |        1.9%             2.6%             84.4%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        727              275              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.628          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.683          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.715          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.632          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.515N         P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.743          P<0.001 **                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/59 (15%)       9/57 (16%)       15/59 (25%)                                                        | 
|POLY-3 RATE (b)    |        9/54.07          9/39.84          15/28.59                                                           | 
|POLY-3 PERCENT (g) |        16.7%            22.6%            52.5%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        555              523              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.044 *        P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.326          P<0.001 **                                                         | 
|POLY 1.5           |        P=0.008 **       P=0.426          P=0.011 *                                                          | 
|POLY 6             |        P<0.001 **       P=0.207          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.029 *        P=0.446          P=0.083                                                            | 
|COCH-ARM / FISHERS |        P=0.089          P=0.570          P=0.126                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/59 (0%)        1/57 (2%)        2/59 (3%)                                                          | 
|POLY-3 RATE (b)    |        0/53.10          1/37.70          2/20.12                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             9.9%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              637              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.380          P=0.046 *                                                          | 
|POLY 3             |        P=0.072          P=0.433          P=0.104                                                            | 
|POLY 1.5           |        P=0.085          P=0.459          P=0.146                                                            | 
|POLY 6             |        P=0.087          P=0.398          P=0.076                                                            | 
|LOGISTIC REGRESSION|        P=0.130          P=0.531          P=0.248                                                            | 
|COCH-ARM / FISHERS |        P=0.163          P=0.491          P=0.248                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       38/60 (63%)      54/59 (92%)                                                        | 
|POLY-3 RATE (b)    |        7/54.53          38/51.02         54/55.43                                                           | 
|POLY-3 PERCENT (g) |        12.8%            74.5%            97.4%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        663              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/60 (67%)      33/60 (55%)      14/59 (24%)                                                        | 
|POLY-3 RATE (b)    |        40/56.29         33/50.22         14/28.29                                                           | 
|POLY-3 PERCENT (g) |        71.1%            65.7%            49.5%                                                              | 
|TERMINAL (d)       |        29/39 (74%)      8/11 (73%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              419              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P=0.043N*        P=0.342N         P=0.041N*                                                          | 
|POLY 1.5           |        P<0.001N**       P=0.239N         P<0.001N**                                                         | 
|POLY 6             |        P=0.475N         P=0.529N         P=0.520N                                                           | 
|LOGISTIC REGRESSION|        P=0.009N**       P=0.372N         P=0.130N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.131N         P<0.001N**                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        24/60 (40%)      17/60 (28%)      8/60 (13%)                                                         | 
|POLY-3 RATE (b)    |        24/57.24         17/43.71         8/25.13                                                            | 
|POLY-3 PERCENT (g) |        41.9%            38.9%            31.8%                                                              | 
|TERMINAL (d)       |        16/39 (41%)      3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              420              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.062          P=0.015 *                                                          | 
|POLY 3             |        P=0.262N         P=0.459N         P=0.290N                                                           | 
|POLY 1.5           |        P=0.038N*        P=0.294N         P=0.045N*                                                          | 
|POLY 6             |        P=0.366          P=0.481          P=0.401                                                            | 
|LOGISTIC REGRESSION|        P=0.011N*        P=0.183N         P=0.004N**                                                         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.124N         P<0.001N**                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Ventral                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/60 (30%)      4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        18/54.46         4/39.09          1/20.15                                                            | 
|POLY-3 PERCENT (g) |        33.1%            10.2%            5.0%                                                               | 
|TERMINAL (d)       |        15/39 (39%)      2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        631              621              412                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.634          P=0.336N         P=0.497                                                            | 
|POLY 3             |        P<0.001N**       P=0.009N**       P=0.033N*                                                          | 
|POLY 1.5           |        P<0.001N**       P=0.003N**       P=0.002N**                                                         | 
|POLY 6             |        P=0.016N*        P=0.036N*        P=0.269N                                                           | 
|LOGISTIC REGRESSION|        P=0.063N         P=0.078N         P=0.236N                                                           | 
|COCH-ARM / FISHERS |        P<0.001N**       P<0.001N**       P<0.001N**                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        16/58 (28%)      49/59 (83%)                                                        | 
|POLY-3 RATE (b)    |        0/53.85          16/43.40         49/53.51                                                           | 
|POLY-3 PERCENT (g) |        0.0%             36.9%            91.6%                                                              | 
|TERMINAL (d)       |        0/39 (0%)        3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              502              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/60 (10%)       14/60 (23%)      27/60 (45%)                                                        | 
|POLY-3 RATE (b)    |        6/54.06          14/40.92         27/35.21                                                           | 
|POLY-3 PERCENT (g) |        11.1%            34.2%            76.7%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       6/11 (55%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        674              531              384                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.006 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.014 *        P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.042 *        P<0.001 **                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/60 (12%)       36/60 (60%)      35/60 (58%)                                                        | 
|POLY-3 RATE (b)    |        7/54.65          36/53.67         35/44.61                                                           | 
|POLY-3 PERCENT (g) |        12.8%            67.1%            78.5%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        537              260              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.155          P<0.001 **       P=0.107                                                            | 
|COCH-ARM / FISHERS |        P<0.001 **       P<0.001 **       P<0.001 **                                                         | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/60 (15%)       4/60 (7%)        7/60 (12%)                                                         | 
|POLY-3 RATE (b)    |        9/55.67          4/39.82          7/23.88                                                            | 
|POLY-3 PERCENT (g) |        16.2%            10.1%            29.3%                                                              | 
|TERMINAL (d)       |        4/39 (10%)       1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              523              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.618N         P=0.002 **                                                         | 
|POLY 3             |        P=0.281          P=0.293N         P=0.185                                                            | 
|POLY 1.5           |        P=0.446          P=0.208N         P=0.422                                                            | 
|POLY 6             |        P=0.154          P=0.429N         P=0.053                                                            | 
|LOGISTIC REGRESSION|        P=0.387N         P=0.098N         P=0.306N                                                           | 
|COCH-ARM / FISHERS |        P=0.401N         P=0.120N         P=0.395N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/59 (7%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        4/54.87          2/39.21          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        7.3%             5.1%             0.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              567              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.341N         P=0.549N         P=0.397N                                                           | 
|POLY 3             |        P=0.250N         P=0.500N         P=0.308N                                                           | 
|POLY 1.5           |        P=0.114N         P=0.426N         P=0.169N                                                           | 
|POLY 6             |        P=0.510N         P=0.599N         P=0.490N                                                           | 
|LOGISTIC REGRESSION|        P=0.007N**       P=0.125N         P=0.002N**                                                         | 
|COCH-ARM / FISHERS |        P=0.041N*        P=0.332N         P=0.057N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/59 (3%)        1/60 (2%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/53.49          1/38.89          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        3.7%             2.6%             0.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        640              658              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.754N         P=0.713N         P=0.992N                                                           | 
|POLY 3             |        P=0.398N         P=0.608N         P=0.484N                                                           | 
|POLY 1.5           |        P=0.253N         P=0.560N         P=0.370N                                                           | 
|POLY 6             |        P=0.612N         P=0.670N         P=0.603N                                                           | 
|LOGISTIC REGRESSION|        P=0.230N         P=0.470N         P=0.327N                                                           | 
|COCH-ARM / FISHERS |        P=0.158N         P=0.494N         P=0.244N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/59 (10%)       4/60 (7%)        1/60 (2%)                                                          | 
|POLY-3 RATE (b)    |        6/55.74          4/39.79          1/19.92                                                            | 
|POLY-3 PERCENT (g) |        10.8%            10.1%            5.0%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              523              540                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.580          P=0.585          P=0.614N                                                           | 
|POLY 3             |        P=0.389N         P=0.587N         P=0.403N                                                           | 
|POLY 1.5           |        P=0.171N         P=0.491N         P=0.207N                                                           | 
|POLY 6             |        P=0.546          P=0.542          P=0.624                                                            | 
|LOGISTIC REGRESSION|        P=0.010N*        P=0.131N         P<0.001N**                                                         | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.361N         P=0.054N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/59 (7%)        7/60 (12%)       3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        4/52.89          7/40.35          3/21.73                                                            | 
|POLY-3 PERCENT (g) |        7.6%             17.4%            13.8%                                                              | 
|TERMINAL (d)       |        3/38 (8%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        720              470              316                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.010 *        P=0.069                                                            | 
|POLY 3             |        P=0.176          P=0.132          P=0.368                                                            | 
|POLY 1.5           |        P=0.403          P=0.184          P=0.556                                                            | 
|POLY 6             |        P=0.043 *        P=0.080          P=0.199                                                            | 
|LOGISTIC REGRESSION|        P=0.591          P=0.127          P=0.511N                                                           | 
|COCH-ARM / FISHERS |        P=0.375N         P=0.274          P=0.491N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/60 (0%)        2/60 (3%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/53.85          2/39.99          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.0%             0.0%                                                               | 
|TERMINAL (d)       |        0/39 (0%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              420              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.649          P=0.213          (e)                                                                | 
|POLY 3             |        P=0.360          P=0.179          (e)                                                                | 
|POLY 1.5           |        P=0.529          P=0.202          (e)                                                                | 
|POLY 6             |        P=0.173          P=0.150          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.281N         P=0.527          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.613N         P=0.248          (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/60 (22%)      18/60 (30%)      53/60 (88%)                                                        | 
|POLY-3 RATE (b)    |        13/56.48         18/44.43         53/56.31                                                           | 
|POLY-3 PERCENT (g) |        23.0%            40.5%            94.1%                                                              | 
|TERMINAL (d)       |        5/39 (13%)       4/11 (36%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        441              499              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.002 **       P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.045 *        P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.089          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.016 *        P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.257          P=0.033 *                                                          | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.202          P<0.001 **                                                         | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/60 (17%)      15/60 (25%)      4/60 (7%)                                                          | 
|POLY-3 RATE (b)    |        10/57.13         15/45.16         4/22.04                                                            | 
|POLY-3 PERCENT (g) |        17.5%            33.2%            18.2%                                                              | 
|TERMINAL (d)       |        2/39 (5%)        2/11 (18%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        533              370              359                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.040 *        P=0.014 *        P=0.169                                                            | 
|POLY 3             |        P=0.212          P=0.053          P=0.586                                                            | 
|POLY 1.5           |        P=0.471N         P=0.094          P=0.344N                                                           | 
|POLY 6             |        P=0.018 *        P=0.022 *        P=0.289                                                            | 
|LOGISTIC REGRESSION|        P=0.004N**       P=0.576N         P=0.007N**                                                         | 
|COCH-ARM / FISHERS |        P=0.055N         P=0.184          P=0.077N                                                           | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/56 (0%)        2/56 (4%)        1/56 (2%)                                                          | 
|POLY-3 RATE (b)    |        0/50.79          2/37.22          1/18.18                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.4%             5.5%                                                               | 
|TERMINAL (d)       |        0/38 (0%)        0/10 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              523              636                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.103          P=0.208          P=0.007 **                                                         | 
|POLY 3             |        P=0.144          P=0.176          P=0.333                                                            | 
|POLY 1.5           |        P=0.228          P=0.200          P=0.398                                                            | 
|POLY 6             |        P=0.089          P=0.148          P=0.277                                                            | 
|LOGISTIC REGRESSION|        P=0.593          P=0.456          P=0.296                                                            | 
|COCH-ARM / FISHERS |        P=0.444          P=0.248          P=0.500                                                            | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/59 (0%)        4/60 (7%)        3/60 (5%)                                                          | 
|POLY-3 RATE (b)    |        0/52.85          4/40.07          3/21.83                                                            | 
|POLY-3 PERCENT (g) |        0.0%             10.0%            13.7%                                                              | 
|TERMINAL (d)       |        0/38 (0%)        1/11 (9%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              555              299                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.016 *        P=0.079                                                            | 
|POLY 3             |        P=0.016 *        P=0.034 *        P=0.036 *                                                          | 
|POLY 1.5           |        P=0.044 *        P=0.044 *        P=0.059                                                            | 
|POLY 6             |        P=0.005 **       P=0.023 *        P=0.022 *                                                          | 
|LOGISTIC REGRESSION|        P=0.530          P=0.081          P=0.892                                                            | 
|COCH-ARM / FISHERS |        P=0.170          P=0.061          P=0.125                                                            | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/59 (17%)      9/60 (15%)       6/60 (10%)                                                         | 
|POLY-3 RATE (b)    |        10/53.36         9/41.81          6/23.38                                                            | 
|POLY-3 PERCENT (g) |        18.7%            21.5%            25.7%                                                              | 
|TERMINAL (d)       |        8/38 (21%)       3/11 (27%)       0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        649              419              362                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.062          P<0.001 **                                                         | 
|POLY 3             |        P=0.323          P=0.469          P=0.370                                                            | 
|POLY 1.5           |        P=0.515N         P=0.573          P=0.558N                                                           | 
|POLY 6             |        P=0.109          P=0.326          P=0.133                                                            | 
|LOGISTIC REGRESSION|        P=0.413N         P=0.606N         P=0.643N                                                           | 
|COCH-ARM / FISHERS |        P=0.168N         P=0.484N         P=0.200N                                                           | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 08                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   O-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0 PPM            2000 PPM         5000 PPM                                                           | 
|                   |                         (STOP)           (STOP)                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/59 (5%)        0/60 (0%)        0/60 (0%)                                                          | 
|POLY-3 RATE (b)    |        3/52.85          0/38.63          0/19.33                                                            | 
|POLY-3 PERCENT (g) |        5.7%             0.0%             0.0%                                                               | 
|TERMINAL (d)       |        3/38 (8%)        0/11 (0%)        0/0 (0%)                                                           | 
|FIRST INCIDENCE    |        729 (T)          ---              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.543N         P=0.403N         P=1.000N                                                           | 
|POLY 3             |        P=0.115N         P=0.186N         P=0.373N                                                           | 
|POLY 1.5           |        P=0.075N         P=0.153N         P=0.242N                                                           | 
|POLY 6             |        P=0.185N         P=0.241N         P=0.531N                                                           | 
|LOGISTIC REGRESSION|        P=0.543N         (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.058N         P=0.119N         P=0.119N                                                           | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).