TDMS Study 05203-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:40:51
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
------------------------------------------------------------------------------------------------------------------------------------
RATS, FINAL#1; CONTROL + 2000 & 5000PPM STOP GROUPS
REASONS FOR REMOVAL: 25022 Accidently Killed
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 009 2000 PPM(STOP)
INCLUDE 010 5000 PPM(STOP)
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst O-NITROTOLUENE DATE: 11/16/00
EXPERIMENT: 05203 TEST: 08 TIME: 09:40:51
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393 ROUTE: DOSED FEED NTP C#: 62340D
PATHOLOGIST: HEATH, JAMES E. CAS: 88-72-2
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 441 533 533 537 555 586 631 640 644 649 |
| 663 673 674 691 705 705 707 714 720 722 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2000 PPM(STOP) |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 49 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 260 275 370 419 420 470 499 502 523 523 |
| 531 534 537 555 567 569 569 569 576 579 |
| 579 579 589 589 592 595 595 603 615 621 |
| 621 637 649 656 658 658 658 670 673 677 |
| 684 685 702 703 708 708 710 716 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM(STOP) |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 60 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 299 299 316 359 359 359 359 362 384 384 |
| 384 384 391 391 391 401 412 417 419 419 |
| 432 439 453 464 464 464 471 485 485 499 |
| 501 502 502 502 502 505 512 512 540 540 |
| 540 544 547 555 555 555 567 567 567 569 |
| 579 581 595 597 597 603 621 632 636 691 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
O-NITROTOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.3 93.3 90.0 81.7 65.0 |
| | |
| | |
|2000 | 100.0 100.0 98.3 96.7 91.7 90.0 78.3 53.3 38.3 18.3 |
|PPM(STOP) | |
| | |
|5000 | 100.0 100.0 100.0 86.7 66.7 51.7 30.0 6.7 1.7 0.0 |
|PPM(STOP) | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 2000 5000 |
| PPM(STOP) PPM(STOP) |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 65.0% 18.3% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 640.5 585.6 482.7 |
|NATURAL DEATHS (C) | (17.5) (15.0) (12.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.0 611.9 482.7 |
|(STANDARD ERROR) | ( 8.1) (14.2) (12.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-NITROTOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
2000 PPM(STOP) = 2
5000 PPM(STOP) = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 2 3 3 2 1 1
| 3 32 2
| 2 2 1 1 1
90 + 2 2 1 1
| 3 3 2 2 11
| 11
| 222 1 1 1
80 + 33
| 2 22 1 1 1
| 3 3 22
| 333 11
P 70 + 22 11
E | 3 3 11
R | 33 1 1
C | 3 3 3 2 2
E 60 +
N | 33
T | 3 3 2 2
| 3 3 222
S 50 +
U | 2 2 2
R | 22
V | 33
I 40 + 33
V | 3 3 2 22
A |
L | 22
30 + 33 2 2
| 33 22
|
| 33 22
20 +
| 333 2 2
|
| 3 33
10 +
| 33 3
| 3 3
| 3 3
0 + 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.