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TDMS Study 05203-09 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                              O-NITROTOLUENE                                             DATE: 11/16/00  
EXPERIMENT: 05203 TEST: 09                                                                                        TIME: 10:00:52    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62340D     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      O-NITROTOLUENE                                              DATE: 11/16/00    
EXPERIMENT: 05203 TEST: 09                                                                                        TIME: 10:32:50    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  62340D      
CONT: N01-ES-55393                                                                                                CAS: 88-72-2      
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                               CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                           
==================================================================================================================================  
           0 PPM                      1250 PPM                           2500 PPM                           5000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     5.1    24.0       4.7     23.4    0.92      250      4.5     22.6    0.88      493      4.2     21.4    0.82      979       
  8     4.1    27.7       4.0     27.1    0.98      184      3.9     26.2    0.95      367      3.6     25.1    0.88      722       
 12     4.6    30.6       4.4     29.0    0.96      191      4.3     28.3    0.93      376      4.2     26.7    0.91      794       
 16     4.7    34.2       4.6     32.3    0.98      179      4.5     30.9    0.96      367      4.0     28.3    0.85      700       
 20     4.5    37.3       4.4     35.9    0.98      154      4.2     33.8    0.93      314      3.8     29.7    0.84      636       
 24     4.9    38.7       4.9     36.4    1.00      168      4.7     34.3    0.96      341      4.0     30.0    0.82      664       
 28     5.1    40.5       5.1     38.4    1.00      165      4.8     35.6    0.94      337      4.2     30.8    0.82      674       
 32     5.0    41.9       5.3     39.9    1.06      165      5.1     36.8    1.02      344      4.2     31.1    0.84      673       
 36     4.9    43.6       4.9     41.0    1.00      148      4.8     37.7    0.98      318      4.0     31.7    0.82      632       
 40     5.2    44.7       5.2     42.1    1.00      153      5.1     38.3    0.98      333      4.3     31.9    0.83      669       
 44     5.2    44.8       5.1     42.7    0.98      149      5.0     39.0    0.96      319      4.2     32.2    0.81      646       
 48     5.0    45.8       5.2     43.2    1.04      152      5.4     39.4    1.08      341      4.6     32.8    0.92      701       
 56     5.3    47.1       5.3     44.4    1.00      150      5.4     40.2    1.02      335      3.8     32.4    0.72      594       
 60     5.3    47.0       5.3     44.0    1.00      150      5.4     40.1    1.02      336                                          
 64     5.3    46.7       5.5     43.4    1.04      159      5.1     40.4    0.96      318                                          
 68     5.4    47.7       5.4     45.0    1.00      151      5.3     40.7    0.98      326                                          
 72     5.5    47.3       5.5     44.6    1.00      154      5.3     41.0    0.96      325                                          
 76     5.8    47.6       5.7     44.2    0.98      160      5.2     39.5    0.90      326                                          
 80     5.6    48.0       5.9     44.8    1.05      166      5.0     38.9    0.89      322                                          
 84     5.7    46.3       5.9     43.4    1.04      170      5.6     37.3    0.98      378                                          
 88     5.4    46.5       5.7     43.6    1.06      163                                                                             
 92     5.0    46.5       5.2     42.1    1.04      154                                                                             
 96     5.3    46.6       5.2     43.1    0.98      151                                                                             
100     5.1    46.8       5.1     43.7    1.00      146      7.1     29.4    1.39      606                                          
104     5.4    46.5       5.4     42.6    1.00      159                                                                             
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.6    27.4       4.4     26.5    0.95      208      4.2     25.7    0.92      412      4.0     24.4    0.87      832       
SD(D)   0.5               0.4             0.03       36      0.3             0.04       70      0.3             0.05      132       
CV(E)  10.8               8.1             2.9      17.4      7.4             3.9      17.0      8.4             5.2      15.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.9    41.3       5.0     39.1    1.00      159      4.8     36.2    0.98      335      4.1     30.9    0.84      666       
SD(D)   0.2               0.3             0.03       10      0.3             0.05       17      0.2             0.03       25       
CV(E)   4.9               5.7             2.8       6.5      6.9             4.6       4.9      5.7             4.0       3.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    5.4    47.0       5.5     43.8    1.01      156      5.5     38.6    1.01      364      3.8     32.4    0.72      594       
SD(D)   0.2               0.3             0.03        7      0.6             0.15       93                                          
CV(E)   4.0               4.8             2.6       4.5     11.6            14.8      25.5                                          
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                               CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                           
==================================================================================================================================  
           0 PPM                      1250 PPM                           2500 PPM                           5000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     3.7    20.6       3.8     21.1     1.03     226      3.7     20.4     1.00     449      3.3     19.4     0.89     857       
  8     3.4    22.4       3.8     23.2     1.12     202      3.6     23.3     1.06     388      3.2     22.1     0.94     731       
 12     3.8    25.7       3.9     25.5     1.03     193      3.9     25.1     1.03     386      3.5     23.2     0.92     761       
 16     4.0    27.8       4.1     27.4     1.03     188      4.0     26.8     1.00     374      3.7     24.3     0.93     758       
 20     3.7    29.4       3.8     29.3     1.03     162      3.9     29.0     1.05     336      3.5     25.4     0.95     697       
 24     4.3    31.8       4.5     32.2     1.05     177      4.2     30.1     0.98     353      3.9     26.4     0.91     733       
 28     4.3    33.2       3.9     33.6     0.91     145      4.1     32.0     0.95     323      3.8     27.1     0.88     704       
 32     4.6    35.4       4.5     35.8     0.98     159      4.7     33.6     1.02     348      4.1     28.0     0.89     727       
 36     4.2    37.3       4.1     36.7     0.98     141      4.4     35.0     1.05     313      3.8     29.0     0.90     647       
 40     4.5    38.1       4.6     37.7     1.02     152      4.4     35.9     0.98     306      3.9     29.5     0.87     666       
 44     4.4    38.1       4.2     38.6     0.95     135      4.3     37.0     0.98     288      3.8     30.5     0.86     616       
 48     4.3    39.3       4.4     38.8     1.02     143      4.3     37.5     1.00     290      3.8     30.4     0.88     628       
 52     4.7    40.4       5.0     40.7     1.06     154      4.8     38.1     1.02     315      4.6     30.6     0.98     747       
 56     4.2    41.8       4.4     42.6     1.05     130      4.2     38.8     1.00     269      3.7     31.5     0.88     592       
 60     5.0    42.4       4.9     42.5     0.98     143      4.8     39.3     0.96     304      4.2     31.6     0.84     673       
 64     4.6    43.7       4.8     43.5     1.04     138      4.4     39.9     0.96     277      4.1     32.2     0.89     644       
 68     4.3    45.2       4.8     44.4     1.12     136      4.5     41.3     1.05     274      4.4     33.4     1.02     662       
 72     4.6    44.5       4.8     44.4     1.04     135      4.5     41.2     0.98     270      4.3     33.3     0.93     643       
 76     4.5    44.8       4.7     43.9     1.04     134      4.4     40.8     0.98     268      4.4     33.8     0.98     653       
 80     4.2    44.8       4.5     44.2     1.07     127      4.4     40.9     1.05     268      4.1     33.6     0.98     613       
 84     4.8    43.8       4.7     42.2     0.98     139      4.5     38.7     0.94     293      4.5     32.8     0.94     687       
 88     5.2    44.7       5.3     43.1     1.02     153      5.1     39.3     0.98     325      5.0     33.4     0.96     745       
 92     4.3    45.1       4.6     43.9     1.07     130      4.5     39.9     1.05     283      4.8     33.0     1.12     722       
 96     4.0    45.0       4.5     45.3     1.13     123      4.1     39.7     1.03     260      5.4     32.7     1.35     832       
100     4.4    46.2       4.8     47.4     1.09     126      4.9     41.3     1.11     296      6.0     32.3     1.36     934       
104     5.1    46.6       5.2     46.9     1.02     139      5.5     41.2     1.08     334                                          
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.6    22.9       3.8     23.3     1.06     207      3.7     22.9     1.03     408      3.4     21.6     0.92     783       
SD(D)   0.2               0.1              0.05      17      0.1              0.03      36      0.2              0.02      66       
CV(E)   5.5               2.4              5.0      8.3      3.6              2.9      8.8      4.6              2.7      8.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.3    35.1       4.3     35.1     1.00     156      4.3     33.5     1.00     325      3.9     28.1     0.91     692       
SD(D)   0.3               0.4              0.05      16      0.3              0.03      28      0.3              0.04      51       
CV(E)   6.6               8.4              4.7     10.6      6.5              3.3      8.7      7.2              4.0      7.3       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.5    44.5       4.8     44.2     1.05     135      4.6     40.2     1.01     286      4.6     32.8     1.02     700       
SD(D)   0.4               0.3              0.05       8      0.4              0.05      23      0.6              0.17      98       
CV(E)   8.1               5.4              4.3      5.9      8.4              5.2      8.1     13.9             16.9     13.9       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                 DIAGNOSTIC TRAILER REPORT                                                                          
                                 FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                  
                                 CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                                         
=========================================================================================================                           
           0 PPM                   1250 PPM                 2500 PPM                 5000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               20.9  60                 20.8  60                 20.9  60                 20.8  60                               
  1               20.9  60                 20.8  60                 20.9  60                 20.8  60                               
  4   5.1  9799   24.0  60     4.7  9781   23.4  60     4.5  9774   22.6  60     4.2  9705   21.4  60                               
  8   4.1  9334   27.7  60     4.0  9613   27.1  60     3.9  9624   26.2  60     3.6  9637   25.1  60                               
 12   4.6  9613   30.6  60     4.4  9659   29.0  60     4.3  9661   28.3  60     4.2  9520   26.7  60                               
 16   4.7  9926   34.2  60     4.6  9864   32.3  60     4.5  9698   30.9  60     4.0  9711   28.3  60                               
 20   4.5  9597   37.3  60     4.4  9703   35.9  60     4.2  9501   33.8  60     3.8  9416   29.7  60                               
 24   4.9 10000   38.7  60     4.9  9832   36.4  60     4.7  9660   34.3  60     4.0  9793   30.0  60                               
 28   5.1  9652   40.5  60     5.1  9676   38.4  60     4.8  9653   35.6  60     4.2  9649   30.8  60                               
 32   5.0  9997   41.9  60     5.3  9904   39.9  60     5.1  9791   36.8  60     4.2  9767   31.1  60                               
 36   4.9  9973   43.6  60     4.9  9854   41.0  60     4.8  9766   37.7  60     4.0  9738   31.7  60                               
 40   5.2  9625   44.7  59     5.2  9749   42.1  60     5.1  9540   38.3  59     4.3  9649   31.9  60                               
 44   5.2  9623   44.8  59     5.1  9787   42.7  60     5.0  9402   39.0  59     4.2  9132   32.2  57                               
 48   5.0  9795   45.8  59     5.2  9912   43.2  60     5.4  9435   39.4  58     4.6  8731   32.8  54                               
 52               46.6  59                 43.8  60                 39.4  58                 32.7  49                               
 56   5.3  9764   47.1  59     5.3  9753   44.4  60     5.4  9294   40.2  57     3.8  5390   32.4  35                               
 60   5.3  9852   47.0  59     5.3  9890   44.0  60     5.4  9138   40.1  56     3.7  1296   33.0   8                               
 64   5.3  9767   46.7  59     5.5  9753   43.4  60     5.1  8511   40.4  53     3.3   484   33.3   3                               
 68   5.4  9884   47.7  59     5.4  9285   45.0  56     5.3  7733   40.7  48                                                        
 72   5.5  9757   47.3  59     5.5  9080   44.6  55     5.3  6649   41.0  41                                                        
 76   5.8  9742   47.6  59     5.7  8843   44.2  54     5.2  5385   39.5  34                                                        
 80   5.6  9806   48.0  59     5.9  8432   44.8  52     5.0  3332   38.9  24                                                        
 84   5.7  9999   46.3  59     5.9  8239   43.4  49     5.6  1448   37.3   9                                                        
 88   5.4  9449   46.5  57     5.7  7541   43.6  47     5.5   656   37.1   4                                                        
 92   5.0  8922   46.5  55     5.2  6877   42.1  45     4.8   324   31.4   2                                                        
 96   5.3  6125   46.6  54     5.2  4713   43.1  42     5.9   114   31.2   1                                                        
100   5.1  8910   46.8  54     5.1  6239   43.7  38     7.1   167   29.4   1                                                        
104   5.4  8583   46.5  52     5.4  5553   42.6  36                                                                                 
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           25.8                     25.1                     24.5                     23.5                                   
14 TO 52          41.8                     39.6                     36.5                     31.1                                   
 > 52             47.0                     43.8                     37.3                     32.9                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                 DIAGNOSTIC TRAILER REPORT                                                                          
                                 FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                
                                 CHRONIC DOSED FEED STUDY OF O-NITROTOLUENE                                                         
=========================================================================================================                           
           0 PPM                   1250 PPM                 2500 PPM                 5000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               16.9  60                 16.7  60                 16.8  60                 16.7  60                               
  1               16.9  60                 16.7  60                 16.8  60                 16.7  60                               
  4   3.7  9754   20.6  60     3.8  9759   21.1  60     3.7  9715   20.4  60     3.3  9626   19.4  60                               
  8   3.4  7314   22.4  60     3.8  7051   23.2  60     3.6  5824   23.3  60     3.2  6879   22.1  60                               
 12   3.8  9648   25.7  60     3.9  9299   25.5  60     3.9  9566   25.1  60     3.5  9280   23.2  60                               
 16   4.0 10045   27.8  60     4.1  9997   27.4  60     4.0  9904   26.8  60     3.7  9844   24.3  60                               
 20   3.7  9350   29.4  60     3.8  9542   29.3  60     3.9  9384   29.0  60     3.5  9835   25.4  60                               
 24   4.3  9900   31.8  60     4.5  9852   32.2  60     4.2  9762   30.1  60     3.9  9715   26.4  60                               
 28   4.3  9662   33.2  60     3.9  9665   33.6  60     4.1  9654   32.0  60     3.8  9660   27.1  60                               
 32   4.6  9595   35.4  60     4.5 10062   35.8  60     4.7  9933   33.6  60     4.1  9876   28.0  60                               
 36   4.2 10027   37.3  60     4.1  9996   36.7  60     4.4  9846   35.0  60     3.8  9810   29.0  60                               
 40   4.5  9728   38.1  60     4.6  9547   37.7  59     4.4  9643   35.9  60     3.9  9635   29.5  60                               
 44   4.4  9331   38.1  59     4.2  9624   38.6  59     4.3  9822   37.0  60     3.8  9852   30.5  60                               
 48   4.3  9849   39.3  59     4.4  9564   38.8  58     4.3  9736   37.5  60     3.8  9658   30.4  60                               
 52   4.7  2606   40.4  59     5.0  2544   40.7  57     4.8  2687   38.1  60     4.6  2676   30.6  60                               
 56   4.2  9712   41.8  58     4.4  9424   42.6  57     4.2  9900   38.8  60     3.7  9870   31.5  60                               
 60   5.0  9756   42.4  58     4.9  9474   42.5  57     4.8  9918   39.3  60     4.2  9471   31.6  58                               
 64   4.6  9711   43.7  58     4.8  9414   43.5  57     4.4  9831   39.9  60     4.1  9286   32.2  57                               
 68   4.3  9696   45.2  58     4.8  9435   44.4  57     4.5  9877   41.3  60     4.4  9202   33.4  56                               
 72   4.6  9414   44.5  57     4.8  9221   44.4  56     4.5  9840   41.2  60     4.3  9000   33.3  55                               
 76   4.5  9562   44.8  57     4.7  9344   43.9  56     4.4  9906   40.8  60     4.4  8484   33.8  52                               
 80   4.2  9426   44.8  57     4.5  8832   44.2  55     4.4  9581   40.9  59     4.1  8260   33.6  51                               
 84   4.8  8843   43.8  56     4.7  9162   42.2  55     4.5  9926   38.7  59     4.5  7317   32.8  43                               
 88   5.2  9095   44.7  55     5.3  8792   43.1  54     5.1  9653   39.3  59     5.0  5786   33.4  35                               
 92   4.3  9119   45.1  55     4.6  8649   43.9  53     4.5  9267   39.9  57     4.8  4910   33.0  30                               
 96   4.0  6209   45.0  55     4.5  5649   45.3  50     4.1  6304   39.7  56     5.4  2506   32.7  23                               
100   4.4  9171   46.2  55     4.8  8202   47.4  49     4.9  8705   41.3  52     6.0  1695   32.3  10                               
104   5.1  8807   46.6  53     5.2  7677   46.9  46     5.5  7761   41.2  47     6.6   709   32.3   6                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.4                     21.6                     21.4                     20.4                                   
14 TO 52          35.1                     35.1                     33.5                     28.1                                   
 > 52             44.5                     44.2                     40.2                     32.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.