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TDMS Study 05203-09 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:02:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           MICE, FINAL#1                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:02:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:02:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  O-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Harderian Gland                        Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Heart                                  Hemangiosarcoma                                                                              
Intestine Large: Cecum                 Carcinoma                                                                                    
Liver                                  Hemangiosarcoma                                                                              
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
                                       Hemangiosarcoma                                                                              
Mesentery                              Hemangiosarcoma                                                                              
Prostate                               Hemangiosarcoma                                                                              
Skeletal Muscle                        Hemangiosarcoma                                                                              
Skin                                   Hemangiosarcoma                                                                              
Stomach, Forestomach                   Squamous Cell Papilloma                                                                      
Tissue NOS                             Hemangiosarcoma                                                                              
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma                                                                              
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Harderian Gland                        Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Intestine Large: Cecum                 Carcinoma                                                                                    
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Mesentery                              Hemangiosarcoma                                                                              
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Skeletal Muscle                        Hemangiosarcoma                                                                              
                                       Sarcoma                                                                                      
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  O-NITROTOLUENE                                    DATE: 11/16/00       
EXPERIMENT: 05203 TEST: 09                                                                                     TIME: 10:02:33       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62340D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 88-72-2         
                                       Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                  
                                       Hemangiosarcoma                                                                              
                                       Sarcoma                                                                                      
Tissue NOS                             Hemangiosarcoma                                                                              
Uterus                                 Hemangiosarcoma                                                                              
All Organs                             Hemangioma                                                                                   
                                       Hemangiosarcoma                                                                              
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   O-NITROTOLUENE               
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/58 (0%)    0/60 (0%)   |1/59 (2%)    0/59 (0%)    0/58 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     2/56.99      0/49.65      0/22.81      0/9.13      |1/55.32      0/53.27      0/55.51      0/39.77      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |1.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/52 (4%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.620N     P=0.336N     P=1.000      P=1.000N    |P=0.473N     P=0.524N     P=0.520N     P=0.927N     | 
|POLY 3             |     P=0.156N     P=0.270N     P=0.462N     P=0.602N    |P=0.248N     P=0.508N     P=0.499N     P=0.564N     | 
|POLY 1.5           |     P=0.119N     P=0.255N     P=0.358N     P=0.463N    |P=0.278N     P=0.505N     P=0.500N     P=0.532N     | 
|POLY 6             |     P=0.201N     P=0.288N     P=0.589N     P=0.679N    |P=0.232N     P=0.511N     P=0.502N     P=0.612N     | 
|LOGISTIC REGRESSION|     P=0.620N     (e)          (e)          (e)         |P=0.473N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.248N     P=0.256N     P=0.248N    |P=0.305N     P=0.500N     P=0.504N     P=0.496N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    1/60 (2%)    1/60 (2%)    0/60 (0%)   |4/60 (7%)    0/60 (0%)    1/60 (2%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     4/56.99      1/49.65      1/23.78      0/9.13      |4/56.31      0/54.01      1/57.18      2/40.12      | 
|POLY-3 PERCENT (g) |     7.0%         2.0%         4.2%         0.0%        |7.1%         0.0%         1.8%         5.0%         | 
|TERMINAL (d)       |     4/52 (8%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |4/52 (8%)    0/46 (0%)    1/47 (2%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      645          ---         |729 (T)      ---          729 (T)      630          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.646      P=0.328N     P=0.006 **   P=1.000N    |P=0.342      P=0.080N     P=0.212N     P=0.186      | 
|POLY 3             |     P=0.196N     P=0.225N     P=0.509N     P=0.483N    |P=0.378N     P=0.067N     P=0.175N     P=0.501N     | 
|POLY 1.5           |     P=0.099N     P=0.205N     P=0.345N     P=0.273N    |P=0.381N     P=0.065N     P=0.175N     P=0.422N     | 
|POLY 6             |     P=0.269N     P=0.252N     P=0.598      P=0.616N    |P=0.366N     P=0.070N     P=0.180N     P=0.624N     | 
|LOGISTIC REGRESSION|     P=0.747N     P=0.328N     P=0.479      (e)         |P=0.599N     (e)          P=0.212N     P=0.646      | 
|COCH-ARM / FISHERS |     P=0.035N*    P=0.182N     P=0.182N     P=0.059N    |P=0.373N     P=0.059N     P=0.182N     P=0.340N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)   |1/60 (2%)    1/60 (2%)    3/60 (5%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     1/56.99      1/49.97      1/24.02      0/9.13      |1/56.31      1/54.32      3/57.40      2/40.34      | 
|POLY-3 PERCENT (g) |     1.8%         2.0%         4.2%         0.0%        |1.8%         1.8%         5.2%         5.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |1/52 (2%)    0/46 (0%)    2/47 (4%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     729 (T)      641          560          ---         |729 (T)      644          672          548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.343      P=0.690      P=0.295      P=1.000N    |P=0.042 *    P=0.743      P=0.281      P=0.092      | 
|POLY 3             |     P=0.581      P=0.730      P=0.549      P=0.721N    |P=0.190      P=0.752      P=0.313      P=0.388      | 
|POLY 1.5           |     P=0.570N     P=0.744      P=0.651      P=0.654N    |P=0.248      P=0.755      P=0.313      P=0.440      | 
|POLY 6             |     P=0.575      P=0.713      P=0.422      P=0.754N    |P=0.131      P=0.749      P=0.308      P=0.310      | 
|LOGISTIC REGRESSION|     P=0.708N     P=0.758N     P=0.796      (e)         |P=0.324      P=0.759N     P=0.308      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.312N     P=0.752N     P=0.752N     P=0.500N    |P=0.325      P=0.752N     P=0.309      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    2/60 (3%)    2/60 (3%)    0/60 (0%)   |5/60 (8%)    1/60 (2%)    4/60 (7%)    4/60 (7%)    | 
|POLY-3 RATE (b)    |     5/56.99      2/49.97      2/24.33      0/9.13      |5/56.31      1/54.32      4/57.40      4/40.70      | 
|POLY-3 PERCENT (g) |     8.8%         4.0%         8.2%         0.0%        |8.9%         1.8%         7.0%         9.8%         | 
|TERMINAL (d)       |     5/52 (10%)   1/34 (3%)    0/0 (0%)     0/0 (0%)    |5/52 (10%)   0/46 (0%)    3/47 (6%)    2/5 (40%)    | 
|FIRST INCIDENCE    |     729 (T)      641          560          ---         |729 (T)      644          672          548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268      P=0.399N     P=0.006 **   P=1.000N    |P=0.034 *    P=0.133N     P=0.555N     P=0.020 *    | 
|POLY 3             |     P=0.298N     P=0.274N     P=0.617N     P=0.443N    |P=0.397      P=0.112N     P=0.488N     P=0.575      | 
|POLY 1.5           |     P=0.123N     P=0.249N     P=0.428N     P=0.215N    |P=0.459      P=0.109N     P=0.488N     P=0.603N     | 
|POLY 6             |     P=0.423N     P=0.307N     P=0.426      P=0.599N    |P=0.335      P=0.115N     P=0.496N     P=0.424      | 
|LOGISTIC REGRESSION|     P=0.611N     P=0.293N     P=0.371      (e)         |P=0.427      P=0.111N     P=0.496N     P=0.506      | 
|COCH-ARM / FISHERS |     P=0.022N*    P=0.219N     P=0.219N     P=0.029N*   |P=0.537      P=0.103N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    2/60 (3%)    0/60 (0%)    2/60 (3%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    0/58 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      2/49.97      0/23.48      2/10.80     |0/56.31      0/54.01      0/56.26      0/38.16      | 
|POLY-3 PERCENT (g) |     0.0%         4.0%         0.0%         18.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          641          ---          386         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.174      (e)          P=0.060     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.092      P=0.210      (e)          P=0.077     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.109      P=0.222      (e)          P=0.112     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.103      P=0.196      (e)          P=0.063     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.281      P=0.242      (e)          P=0.783     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.248      P=0.248      (e)          P=0.248     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large: Cecum                                                                                                           | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    12/60 (20%)  9/60 (15%)   0/60 (0%)   |0/60 (0%)    1/60 (2%)    4/60 (7%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     0/56.99      12/52.82     9/28.51      0/9.13      |0/56.31      1/54.01      4/57.24      3/40.36      | 
|POLY-3 PERCENT (g) |     0.0%         22.7%        31.6%        0.0%        |0.0%         1.9%         7.0%         7.4%         | 
|TERMINAL (d)       |     0/52 (0%)    4/34 (12%)   0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    3/47 (6%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     ---          485          270          ---         |---          729 (T)      715          619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |P<0.001 **   P=0.476      P=0.053      P=0.008 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |P=0.024 *    P=0.492      P=0.064      P=0.072      | 
|POLY 1.5           |     P=0.042 *    P<0.001 **   P<0.001 **   (e)         |P=0.041 *    P=0.495      P=0.064      P=0.092      | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |P=0.012 *    P=0.488      P=0.062      P=0.050      | 
|LOGISTIC REGRESSION|     P=0.352N     P<0.001 **   P=0.028 *    (e)         |P=0.016 *    P=0.476      P=0.060      P=0.077      | 
|COCH-ARM / FISHERS |     P=0.187N     P<0.001 **   P<0.001 **   (e)         |P=0.072      P=0.500      P=0.059      P=0.122      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     2/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      1/39.91      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     2/52 (4%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.620N     P=0.336N     P=1.000N     P=1.000N    |P=0.053      (e)          (e)          P=0.201      | 
|POLY 3             |     P=0.154N     P=0.270N     P=0.456N     P=0.602N    |P=0.163      (e)          (e)          P=0.433      | 
|POLY 1.5           |     P=0.117N     P=0.255N     P=0.351N     P=0.463N    |P=0.178      (e)          (e)          P=0.465      | 
|POLY 6             |     P=0.200N     P=0.288N     P=0.586N     P=0.679N    |P=0.179      (e)          (e)          P=0.386      | 
|LOGISTIC REGRESSION|     P=0.620N     (e)          (e)          (e)         |P=0.167      (e)          (e)          P=0.415      | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.248N     P=0.248N     P=0.248N    |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    1/60 (2%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     2/56.99      1/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      1/39.91      | 
|POLY-3 PERCENT (g) |     3.5%         2.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     2/52 (4%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.835N     P=0.646N     P=1.000N     P=1.000N    |P=0.053      (e)          (e)          P=0.201      | 
|POLY 3             |     P=0.322N     P=0.548N     P=0.456N     P=0.602N    |P=0.163      (e)          (e)          P=0.433      | 
|POLY 1.5           |     P=0.174N     P=0.527N     P=0.351N     P=0.463N    |P=0.178      (e)          (e)          P=0.465      | 
|POLY 6             |     P=0.530N     P=0.573N     P=0.586N     P=0.679N    |P=0.179      (e)          (e)          P=0.386      | 
|LOGISTIC REGRESSION|     P=0.835N     P=0.646N     (e)          (e)         |P=0.167      (e)          (e)          P=0.415      | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.248N     P=0.248N    |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    4/59 (7%)    1/57 (2%)    0/60 (0%)   |0/60 (0%)    0/59 (0%)    1/59 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/56.99      4/49.88      1/23.28      0/9.13      |0/56.31      0/53.32      1/56.29      0/39.77      | 
|POLY-3 PERCENT (g) |     1.8%         8.0%         4.3%         0.0%        |0.0%         0.0%         1.8%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      641          588          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.098      P=0.139      P=1.000N    |P=0.527      (e)          P=0.480      (e)          | 
|POLY 3             |     P=0.257      P=0.142      P=0.542      P=0.721N    |P=0.517      (e)          P=0.500      (e)          | 
|POLY 1.5           |     P=0.582N     P=0.156      P=0.642      P=0.654N    |P=0.609      (e)          P=0.500      (e)          | 
|POLY 6             |     P=0.070      P=0.127      P=0.419      P=0.754N    |P=0.413      (e)          P=0.497      (e)          | 
|LOGISTIC REGRESSION|     P=0.434      P=0.155      P=0.719      (e)         |(e)          (e)          P=0.480      (e)          | 
|COCH-ARM / FISHERS |     P=0.166N     P=0.177      P=0.739      P=0.500N    |P=0.694      (e)          P=0.496      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/60 (30%)  18/59 (31%)  3/57 (5%)    0/60 (0%)   |7/60 (12%)   5/59 (8%)    19/59 (32%)  29/60 (48%)  | 
|POLY-3 RATE (b)    |     18/57.33     18/51.36     3/24.45      0/9.13      |7/56.31      5/53.32      19/56.66     29/46.76     | 
|POLY-3 PERCENT (g) |     31.4%        35.0%        12.3%        0.0%        |12.4%        9.4%         33.5%        62.0%        | 
|TERMINAL (d)       |     17/52 (33%)  14/34 (41%)  0/0 (0%)     0/0 (0%)    |7/52 (14%)   5/46 (11%)   17/47 (36%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     637          451          470          ---         |729 (T)      729 (T)      673          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.117      P=0.008 **   P=1.000N    |P<0.001 **   P=0.468N     P=0.003 **   P<0.001 **   | 
|POLY 3             |     P=0.118N     P=0.421      P=0.087N     P=0.183N    |P<0.001 **   P=0.419N     P=0.006 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001N**   P=0.482      P=0.010N*    P=0.008N**  |P<0.001 **   P=0.410N     P=0.006 **   P<0.001 **   | 
|POLY 6             |     P=0.424      P=0.345      P=0.439N     P=0.506N    |P<0.001 **   P=0.430N     P=0.005 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.299N     P=0.417      P=0.551N     P=0.982N    |P<0.001 **   P=0.468N     P=0.005 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.555      P<0.001N**   P<0.001N**  |P<0.001 **   P=0.393N     P=0.006 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/60 (20%)  16/59 (27%)  5/57 (9%)    2/60 (3%)   |2/60 (3%)    4/59 (7%)    6/59 (10%)   16/60 (27%)  | 
|POLY-3 RATE (b)    |     12/58.54     16/50.92     5/24.91      2/10.84     |2/57.19      4/53.32      6/56.62      16/44.16     | 
|POLY-3 PERCENT (g) |     20.5%        31.4%        20.1%        18.5%       |3.5%         7.5%         10.6%        36.2%        | 
|TERMINAL (d)       |     7/52 (14%)   10/34 (29%)  0/0 (0%)     0/0 (0%)    |1/52 (2%)    4/46 (9%)    4/47 (9%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     596          451          556          350         |362          729 (T)      661          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.054      P<0.001 **   P=0.083     |P<0.001 **   P=0.291      P=0.120      P<0.001 **   | 
|POLY 3             |     P=0.354      P=0.138      P=0.587N     P=0.562N    |P<0.001 **   P=0.307      P=0.132      P<0.001 **   | 
|POLY 1.5           |     P=0.143N     P=0.180      P=0.295N     P=0.189N    |P<0.001 **   P=0.314      P=0.133      P<0.001 **   | 
|POLY 6             |     P=0.034 *    P=0.095      P=0.263      P=0.372     |P<0.001 **   P=0.298      P=0.128      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.568      P=0.229      P=0.560N     P=0.062N    |P<0.001 **   P=0.350      P=0.081      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.242      P=0.071N     P=0.004N**  |P<0.001 **   P=0.332      P=0.131      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/60 (22%)  17/59 (29%)  5/57 (9%)    2/60 (3%)   |2/60 (3%)    4/59 (7%)    6/59 (10%)   16/60 (27%)  | 
|POLY-3 RATE (b)    |     13/58.58     17/50.92     5/24.91      2/10.84     |2/57.19      4/53.32      6/56.62      16/44.16     | 
|POLY-3 PERCENT (g) |     22.2%        33.4%        20.1%        18.5%       |3.5%         7.5%         10.6%        36.2%        | 
|TERMINAL (d)       |     7/52 (14%)   10/34 (29%)  0/0 (0%)     0/0 (0%)    |1/52 (2%)    4/46 (9%)    4/47 (9%)    1/5 (20%)    | 
|FIRST INCIDENCE    |     596          451          556          350         |362          729 (T)      661          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.052      P<0.001 **   P=0.083     |P<0.001 **   P=0.291      P=0.120      P<0.001 **   | 
|POLY 3             |     P=0.399      P=0.136      P=0.526N     P=0.531N    |P<0.001 **   P=0.307      P=0.132      P<0.001 **   | 
|POLY 1.5           |     P=0.105N     P=0.181      P=0.234N     P=0.155N    |P<0.001 **   P=0.314      P=0.133      P<0.001 **   | 
|POLY 6             |     P=0.036 *    P=0.091      P=0.296      P=0.385     |P<0.001 **   P=0.298      P=0.128      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.553      P=0.222      P=0.521N     P=0.057N    |P<0.001 **   P=0.350      P=0.081      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.246      P=0.046N*    P=0.002N**  |P<0.001 **   P=0.332      P=0.131      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/60 (45%)  28/59 (47%)  7/57 (12%)   2/60 (3%)   |9/60 (15%)   9/59 (15%)   24/59 (41%)  39/60 (65%)  | 
|POLY-3 RATE (b)    |     27/58.54     28/52.13     7/26.18      2/10.84     |9/57.19      9/53.32      24/56.99     39/49.33     | 
|POLY-3 PERCENT (g) |     46.1%        53.7%        26.7%        18.5%       |15.7%        16.9%        42.1%        79.1%        | 
|TERMINAL (d)       |     22/52 (42%)  19/34 (56%)  0/0 (0%)     0/0 (0%)    |8/52 (15%)   9/46 (20%)   20/47 (43%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     596          451          470          350         |362          729 (T)      661          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.042 *    P<0.001 **   P=0.083     |P<0.001 **   P=0.494      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.149N     P=0.271      P=0.093N     P=0.198N    |P<0.001 **   P=0.538      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001N**   P=0.354      P=0.006N**   P=0.003N**  |P<0.001 **   P=0.553      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.189      P=0.181      P=0.581N     P=0.518     |P<0.001 **   P=0.521      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.421N     P=0.324      P=0.343N     P=0.146N    |P<0.001 **   P=0.573      P=0.002 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.466      P<0.001N**   P<0.001N**  |P<0.001 **   P=0.585      P=0.002 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/60 (47%)  29/59 (49%)  7/57 (12%)   2/60 (3%)   |9/60 (15%)   9/59 (15%)   24/59 (41%)  39/60 (65%)  | 
|POLY-3 RATE (b)    |     28/58.58     29/52.13     7/26.18      2/10.84     |9/57.19      9/53.32      24/56.99     39/49.33     | 
|POLY-3 PERCENT (g) |     47.8%        55.6%        26.7%        18.5%       |15.7%        16.9%        42.1%        79.1%        | 
|TERMINAL (d)       |     22/52 (42%)  19/34 (56%)  0/0 (0%)     0/0 (0%)    |8/52 (15%)   9/46 (20%)   20/47 (43%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     596          451          470          350         |362          729 (T)      661          567          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.040 *    P<0.001 **   P=0.083     |P<0.001 **   P=0.494      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.125N     P=0.262      P=0.073N     P=0.181N    |P<0.001 **   P=0.538      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001N**   P=0.348      P=0.003N**   P=0.002N**  |P<0.001 **   P=0.553      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.192      P=0.170      P=0.548N     P=0.526     |P<0.001 **   P=0.521      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.435N     P=0.310      P=0.314N     P=0.139N    |P<0.001 **   P=0.573      P=0.002 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.465      P<0.001N**   P<0.001N**  |P<0.001 **   P=0.585      P=0.002 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/60 (15%)   6/60 (10%)   4/60 (7%)    0/60 (0%)   |2/60 (3%)    3/60 (5%)    4/59 (7%)    4/57 (7%)    | 
|POLY-3 RATE (b)    |     9/56.99      6/51.06      4/26.03      0/9.13      |2/56.31      3/54.01      4/56.37      4/38.86      | 
|POLY-3 PERCENT (g) |     15.8%        11.8%        15.4%        0.0%        |3.6%         5.6%         7.1%         10.3%        | 
|TERMINAL (d)       |     9/52 (17%)   3/34 (9%)    0/0 (0%)     0/0 (0%)    |2/52 (4%)    3/46 (7%)    3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      469          434          ---         |729 (T)      729 (T)      701          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.583N     P=0.010 *    P=1.000N    |P=0.004 **   P=0.444      P=0.297      P=0.022 *    | 
|POLY 3             |     P=0.323N     P=0.372N     P=0.595N     P=0.332N    |P=0.126      P=0.481      P=0.339      P=0.190      | 
|POLY 1.5           |     P=0.064N     P=0.336N     P=0.345N     P=0.086N    |P=0.172      P=0.488      P=0.339      P=0.244      | 
|POLY 6             |     P=0.604N     P=0.420N     P=0.314      P=0.555N    |P=0.083      P=0.472      P=0.332      P=0.124      | 
|LOGISTIC REGRESSION|     P=0.049N*    P=0.311N     P=0.585N     (e)         |P=0.170      P=0.444      P=0.328      P=0.325      | 
|COCH-ARM / FISHERS |     P=0.002N**   P=0.291N     P=0.120N     P<0.001N**  |P=0.240      P=0.500      P=0.332      P=0.315      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    1/60 (2%)    2/60 (3%)    0/60 (0%)   |3/60 (5%)    3/60 (5%)    0/59 (0%)    2/57 (4%)    | 
|POLY-3 RATE (b)    |     5/57.29      1/49.65      2/24.63      0/9.13      |3/56.31      3/54.57      0/56.26      2/38.33      | 
|POLY-3 PERCENT (g) |     8.7%         2.0%         8.1%         0.0%        |5.3%         5.5%         0.0%         5.2%         | 
|TERMINAL (d)       |     4/52 (8%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |3/52 (6%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     649          729 (T)      544          ---         |729 (T)      553          ---          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.494      P=0.218N     P=0.104      P=1.000N    |P=0.509      P=0.612      P=0.140N     P=0.272      | 
|POLY 3             |     P=0.219N     P=0.140N     P=0.614N     P=0.444N    |P=0.358N     P=0.647      P=0.120N     P=0.666N     | 
|POLY 1.5           |     P=0.106N     P=0.123N     P=0.427N     P=0.216N    |P=0.352N     P=0.652      P=0.120N     P=0.600N     | 
|POLY 6             |     P=0.265N     P=0.164N     P=0.431      P=0.599N    |P=0.359N     P=0.640      P=0.123N     P=0.574      | 
|LOGISTIC REGRESSION|     P=0.265N     P=0.143N     P=0.700N     P=0.991N    |P=0.283N     P=0.662      (e)          P=0.560N     | 
|COCH-ARM / FISHERS |     P=0.026N*    P=0.103N     P=0.219N     P=0.029N*   |P=0.333N     P=0.660N     P=0.125N     P=0.524N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/60 (23%)  7/60 (12%)   6/60 (10%)   0/60 (0%)   |5/60 (8%)    6/60 (10%)   4/59 (7%)    6/57 (11%)   | 
|POLY-3 RATE (b)    |     14/57.29     7/51.06      6/27.18      0/9.13      |5/56.31      6/54.57      4/56.37      6/39.73      | 
|POLY-3 PERCENT (g) |     24.4%        13.7%        22.1%        0.0%        |8.9%         11.0%        7.1%         15.1%        | 
|TERMINAL (d)       |     13/52 (25%)  4/34 (12%)   0/0 (0%)     0/0 (0%)    |5/52 (10%)   5/46 (11%)   3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     649          469          434          ---         |729 (T)      553          701          488          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.089      P=0.308N     P<0.001 **   P=1.000N    |P=0.011 *    P=0.422      P=0.559N     P=0.010 *    | 
|POLY 3             |     P=0.136N     P=0.121N     P=0.513N     P=0.241N    |P=0.293      P=0.478      P=0.499N     P=0.273      | 
|POLY 1.5           |     P=0.014N*    P=0.098N     P=0.221N     P=0.026N*   |P=0.358      P=0.486      P=0.499N     P=0.360      | 
|POLY 6             |     P=0.340N     P=0.157N     P=0.291      P=0.525N    |P=0.224      P=0.468      P=0.508N     P=0.164      | 
|LOGISTIC REGRESSION|     P=0.017N*    P=0.096N     P=0.484N     P=0.989N    |P=0.436      P=0.482      P=0.522N     P=0.464      | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.074N     P=0.042N*    P<0.001N**  |P=0.446      P=0.500      P=0.511N     P=0.464      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    4/60 (7%)   |0/60 (0%)    0/60 (0%)    0/59 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      4/12.46     |0/56.31      0/54.01      0/56.26      0/37.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         32.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          358         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          (e)          P=0.003 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.014 *    (e)          (e)          P=0.006 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.002 **   (e)          (e)          P=0.012 *   |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.103      (e)          (e)          P=0.004 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.145      (e)          (e)          P=0.539     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.003 **   (e)          (e)          P=0.059     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    8/60 (13%)   38/60 (63%)  38/60 (63%) |0/60 (0%)    0/60 (0%)    0/60 (0%)    32/60 (53%)  | 
|POLY-3 RATE (b)    |     0/56.99      8/50.49      38/45.78     38/40.95    |0/56.31      0/54.01      0/57.18      32/48.83     | 
|POLY-3 PERCENT (g) |     0.0%         15.8%        83.0%        92.8%       |0.0%         0.0%         0.0%         65.5%        | 
|TERMINAL (d)       |     0/52 (0%)    5/34 (15%)   0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    4/5 (80%)    | 
|FIRST INCIDENCE    |     ---          572          410          297         |---          ---          ---          507          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/59 (2%)    0/56 (0%)    2/56 (4%)    0/56 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/55.31      0/51.25      2/53.29      0/36.99      | 
|POLY-3 PERCENT (g) |                                                        |1.8%         0.0%         3.8%         0.0%         | 
|TERMINAL (d)       |                                                        |1/51 (2%)    0/45 (0%)    2/44 (5%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.539      P=0.525N     P=0.449      P=0.925N     | 
|POLY 3             |                                                        |P=0.574N     P=0.515N     P=0.487      P=0.578N     | 
|POLY 1.5           |                                                        |P=0.527N     P=0.513N     P=0.488      P=0.546N     | 
|POLY 6             |                                                        |P=0.552      P=0.518N     P=0.481      P=0.624N     | 
|LOGISTIC REGRESSION|                                                        |P=0.539      (e)          P=0.449      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.472N     P=0.513N     P=0.480      P=0.513N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Luteoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/59 (3%)    0/56 (0%)    1/56 (2%)    1/56 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/55.31      0/51.25      1/53.29      1/36.99      | 
|POLY-3 PERCENT (g) |                                                        |3.6%         0.0%         1.9%         2.7%         | 
|TERMINAL (d)       |                                                        |2/51 (4%)    0/45 (0%)    1/44 (2%)    1/5 (20%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.344      P=0.267N     P=0.551N     P=0.316      | 
|POLY 3             |                                                        |P=0.533N     P=0.255N     P=0.513N     P=0.634N     | 
|POLY 1.5           |                                                        |P=0.529N     P=0.252N     P=0.512N     P=0.580N     | 
|POLY 6             |                                                        |P=0.546N     P=0.259N     P=0.519N     P=0.710N     | 
|LOGISTIC REGRESSION|                                                        |P=0.344      (e)          P=0.551N     P=0.316      | 
|COCH-ARM / FISHERS |                                                        |P=0.513N     P=0.261N     P=0.520N     P=0.520N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/53 (2%)    0/50 (0%)    0/50 (0%)    0/46 (0%)   |3/58 (5%)    4/58 (7%)    3/53 (6%)    0/53 (0%)    | 
|POLY-3 RATE (b)    |     1/51.28      0/41.29      0/19.25      0/6.89      |3/56.12      4/53.48      3/50.37      0/35.53      | 
|POLY-3 PERCENT (g) |     2.0%         0.0%         0.0%         0.0%        |5.4%         7.5%         6.0%         0.0%         | 
|TERMINAL (d)       |     1/47 (2%)    0/29 (0%)    0/0 (0%)     0/0 (0%)    |2/51 (4%)    3/46 (7%)    3/42 (7%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |299          644          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.899N     P=0.596N     P=1.000N     P=1.000N    |P=0.435N     P=0.456      P=0.585      P=0.390N     | 
|POLY 3             |     P=0.418N     P=0.543N     P=0.662N     P=0.735N    |P=0.201N     P=0.474      P=0.611      P=0.221N     | 
|POLY 1.5           |     P=0.313N     P=0.530N     P=0.600N     P=0.676N    |P=0.148N     P=0.482      P=0.616      P=0.179N     | 
|POLY 6             |     P=0.543N     P=0.557N     P=0.724N     P=0.763N    |P=0.309N     P=0.467      P=0.601      P=0.296N     | 
|LOGISTIC REGRESSION|     P=0.899N     (e)          (e)          (e)         |P=0.066N     P=0.549      P=0.534      P=0.047N*    | 
|COCH-ARM / FISHERS |     P=0.321N     P=0.515N     P=0.515N     P=0.535N    |P=0.096N     P=0.500      P=0.617      P=0.139N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/59 (0%)    4/57 (7%)    0/58 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/56.99      0/48.73      4/23.82      0/8.87      |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         16.8%        0.0%        |                                                    | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |                                                    | 
|FIRST INCIDENCE    |     ---          ---          476          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   (e)          P<0.001 **   (e)         |                                                    | 
|POLY 3             |     P=0.029 *    (e)          P=0.011 *    (e)         |                                                    | 
|POLY 1.5           |     P=0.084      (e)          P=0.022 *    (e)         |                                                    | 
|POLY 6             |     P=0.074      (e)          P=0.005 **   (e)         |                                                    | 
|LOGISTIC REGRESSION|     P=0.703      (e)          P=0.137      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.490      (e)          P=0.053      (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    6/60 (10%)   33/60 (55%)  45/60 (75%) |0/60 (0%)    0/60 (0%)    0/60 (0%)    16/60 (27%)  | 
|POLY-3 RATE (b)    |     0/56.99      6/51.27      33/41.72     45/47.22    |0/56.31      0/54.01      0/57.18      16/44.94     | 
|POLY-3 PERCENT (g) |     0.0%         11.7%        79.1%        95.3%       |0.0%         0.0%         0.0%         35.6%        | 
|TERMINAL (d)       |     0/52 (0%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          542          365          277         |---          ---          ---          444          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.013 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.028 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.014 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          (e)          P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    1/60 (2%)    3/60 (5%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      1/54.01      3/58.04      2/40.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         1.9%         5.2%         5.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      553          583          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.022 *    P=0.476      P=0.120      P=0.066      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.074      P=0.492      P=0.125      P=0.173      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.110      P=0.495      P=0.124      P=0.202      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.044 *    P=0.488      P=0.124      P=0.136      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.214      P=0.476      P=0.062      P=0.259      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.164      P=0.500      P=0.122      P=0.248      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      2/54.76      0/57.18      1/39.92      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.7%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          553          ---          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.366      P=0.227      (e)          P=0.230      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.437      P=0.232      (e)          P=0.433      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.483      P=0.234      (e)          P=0.465      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.402      P=0.229      (e)          P=0.386      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.607      P=0.262      (e)          P=0.427      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539      P=0.248      (e)          P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)   |1/60 (2%)    1/60 (2%)    6/60 (10%)   2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      1/24.15      0/9.13      |1/56.38      1/54.01      6/57.89      2/39.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.1%         0.0%        |1.8%         1.9%         10.4%        5.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          504          ---         |710          729 (T)      661          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.442      (e)          P=0.427      (e)         |P=0.009 **   P=0.734      P=0.056      P=0.043 *    | 
|POLY 3             |     P=0.419      (e)          P=0.353      (e)         |P=0.112      P=0.751      P=0.062      P=0.384      | 
|POLY 1.5           |     P=0.419      (e)          P=0.415      (e)         |P=0.184      P=0.754      P=0.062      P=0.438      | 
|POLY 6             |     P=0.640      (e)          P=0.288      (e)         |P=0.050      P=0.746      P=0.061      P=0.306      | 
|LOGISTIC REGRESSION|     P=0.772N     (e)          P=0.748      (e)         |P=0.161      P=0.753      P=0.052      P=0.249      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.293      P=0.752N     P=0.057      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    0/60 (0%)   |1/60 (2%)    1/60 (2%)    6/60 (10%)   2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      1/24.15      0/9.13      |1/56.38      1/54.01      6/57.89      2/39.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.1%         0.0%        |1.8%         1.9%         10.4%        5.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          504          ---         |710          729 (T)      661          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.442      (e)          P=0.427      (e)         |P=0.009 **   P=0.734      P=0.056      P=0.043 *    | 
|POLY 3             |     P=0.419      (e)          P=0.353      (e)         |P=0.112      P=0.751      P=0.062      P=0.384      | 
|POLY 1.5           |     P=0.419      (e)          P=0.415      (e)         |P=0.184      P=0.754      P=0.062      P=0.438      | 
|POLY 6             |     P=0.640      (e)          P=0.288      (e)         |P=0.050      P=0.746      P=0.061      P=0.306      | 
|LOGISTIC REGRESSION|     P=0.772N     (e)          P=0.748      (e)         |P=0.161      P=0.753      P=0.052      P=0.249      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.293      P=0.752N     P=0.057      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    4/60 (7%)    8/60 (13%)   20/60 (33%) |0/60 (0%)    0/60 (0%)    2/60 (3%)    19/60 (32%)  | 
|POLY-3 RATE (b)    |     0/56.99      4/50.29      8/27.25      20/25.99    |0/56.31      0/54.01      2/57.56      19/43.97     | 
|POLY-3 PERCENT (g) |     0.0%         8.0%         29.4%        77.0%       |0.0%         0.0%         3.5%         43.2%        | 
|TERMINAL (d)       |     0/52 (0%)    2/34 (6%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    1/47 (2%)    2/5 (40%)    | 
|FIRST INCIDENCE    |     ---          542          544          326         |---          ---          624          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.032 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.234      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.047 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.243      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.053      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.242      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.041 *    P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.240      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.068      P<0.001 **   P=0.053     |P<0.001 **   (e)          P=0.200      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.059      P=0.003 **   P<0.001 **  |P<0.001 **   (e)          P=0.248      P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |1/60 (2%)    1/60 (2%)    6/60 (10%)   2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |1/56.38      1/54.01      6/57.89      2/39.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |1.8%         1.9%         10.4%        5.0%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |710          729 (T)      661          696          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.009 **   P=0.734      P=0.056      P=0.043 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.112      P=0.751      P=0.062      P=0.384      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.184      P=0.754      P=0.062      P=0.438      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.050      P=0.746      P=0.061      P=0.306      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.161      P=0.753      P=0.052      P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.293      P=0.752N     P=0.057      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Carcinoma, Basal Cell Carcinoma, Basosquamous                                                                 | 
|     Tumor (malignant or NOS), or Carcinoma                                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/60 (3%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      0/9.13      |0/56.31      2/54.76      0/57.18      1/39.92      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         3.7%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          553          ---          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.366      P=0.227      (e)          P=0.230      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.437      P=0.232      (e)          P=0.433      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.483      P=0.234      (e)          P=0.465      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.402      P=0.229      (e)          P=0.386      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.607      P=0.262      (e)          P=0.427      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539      P=0.248      (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    3/60 (5%)    0/58 (0%)    0/60 (0%)   |0/59 (0%)    0/57 (0%)    0/58 (0%)    0/57 (0%)    | 
|POLY-3 RATE (b)    |     2/57.07      3/50.02      0/22.92      0/9.13      |0/55.32      0/53.12      0/55.37      0/37.66      | 
|POLY-3 PERCENT (g) |     3.5%         6.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     710          641          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534      P=0.346      P=1.000N     P=1.000N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.589N     P=0.441      P=0.462N     P=0.602N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.252N     P=0.466      P=0.358N     P=0.463N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.466      P=0.410      P=0.588N     P=0.679N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.792N     P=0.461      P=0.981N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.075N     P=0.500      P=0.256N     P=0.248N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)   |1/60 (2%)    2/60 (3%)    2/60 (3%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      0/23.48      2/10.78     |1/56.77      2/54.01      2/57.18      1/39.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         18.6%       |1.8%         3.7%         3.5%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    2/46 (4%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          391         |592          729 (T)      729 (T)      688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   (e)          (e)          P=0.037 *   |P=0.238      P=0.470      P=0.483      P=0.584      | 
|POLY 3             |     P=0.149      (e)          (e)          P=0.077     |P=0.495      P=0.483      P=0.503      P=0.676      | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.112     |P=0.575      P=0.489      P=0.504      P=0.718      | 
|POLY 6             |     P=0.506      (e)          (e)          P=0.063     |P=0.398      P=0.474      P=0.495      P=0.603      | 
|LOGISTIC REGRESSION|     P=0.313      (e)          (e)          P=0.762     |P=0.610      P=0.509      P=0.463      P=0.728N     | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.248     |P=0.556N     P=0.500      P=0.500      P=0.752N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tissue NOS                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/60 (0%)    0/60 (0%)    1/60 (2%)    2/60 (3%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    2/60 (3%)    | 
|POLY-3 RATE (b)    |     0/56.99      0/49.65      1/24.22      2/10.87     |0/56.31      0/54.01      0/57.18      2/40.54      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.1%         18.4%       |0.0%         0.0%         0.0%         4.9%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          466          339         |---          ---          ---          608          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011 *    (e)          P=0.471      P=0.166     |P=0.020 *    (e)          (e)          P=0.149      | 
|POLY 3             |     P=0.073      (e)          P=0.353      P=0.077     |P=0.038 *    (e)          (e)          P=0.174      | 
|POLY 1.5           |     P=0.034 *    (e)          P=0.415      P=0.112     |P=0.041 *    (e)          (e)          P=0.202      | 
|POLY 6             |     P=0.308      (e)          P=0.289      P=0.063     |P=0.046 *    (e)          (e)          P=0.138      | 
|LOGISTIC REGRESSION|     P=0.607      (e)          P=0.773      P=0.844     |P=0.077      (e)          (e)          P=0.302      | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.248     |P=0.046 *    (e)          (e)          P=0.248      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tissue NOS                                                                                                                       | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/60 (3%)    0/60 (0%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    0/60 (0%)    0/60 (0%)    1/60 (2%)    | 
|POLY-3 RATE (b)    |     2/57.37      0/49.65      0/23.48      0/9.13      |0/56.31      0/54.01      0/57.18      1/39.91      | 
|POLY-3 PERCENT (g) |     3.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.5%         | 
|TERMINAL (d)       |     0/52 (0%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     649          ---          ---          ---         |---          ---          ---          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.574N     P=0.307N     P=1.000N     P=1.000N    |P=0.053      (e)          (e)          P=0.201      | 
|POLY 3             |     P=0.155N     P=0.271N     P=0.458N     P=0.603N    |P=0.163      (e)          (e)          P=0.433      | 
|POLY 1.5           |     P=0.118N     P=0.256N     P=0.351N     P=0.464N    |P=0.178      (e)          (e)          P=0.465      | 
|POLY 6             |     P=0.203N     P=0.291N     P=0.587N     P=0.679N    |P=0.179      (e)          (e)          P=0.386      | 
|LOGISTIC REGRESSION|     P=0.206N     P=0.217N     P=0.491N     P=0.975N    |P=0.167      (e)          (e)          P=0.415      | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.248N     P=0.248N     P=0.248N    |P=0.199      (e)          (e)          P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/60 (2%)    2/60 (3%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/56.31      2/54.01      0/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |                                                        |1.8%         3.7%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/52 (2%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.453N     P=0.457      P=0.520N     P=0.927N     | 
|POLY 3             |                                                        |P=0.211N     P=0.485      P=0.497N     P=0.567N     | 
|POLY 1.5           |                                                        |P=0.203N     P=0.491      P=0.497N     P=0.536N     | 
|POLY 6             |                                                        |P=0.240N     P=0.479      P=0.500N     P=0.615N     | 
|LOGISTIC REGRESSION|                                                        |P=0.453N     P=0.457      (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/60 (0%)    1/60 (2%)    0/60 (0%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |                                                        |0/56.31      1/54.01      0/57.18      3/40.93      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         1.9%         0.0%         7.3%         | 
|TERMINAL (d)       |                                                        |0/52 (0%)    1/46 (2%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      ---          522          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.005 **   P=0.476      (e)          P=0.043 *    | 
|POLY 3             |                                                        |P=0.033 *    P=0.492      (e)          P=0.074      | 
|POLY 1.5           |                                                        |P=0.037 *    P=0.495      (e)          P=0.093      | 
|POLY 6             |                                                        |P=0.036 *    P=0.488      (e)          P=0.051      | 
|LOGISTIC REGRESSION|                                                        |P=0.073      P=0.476      (e)          P=0.180      | 
|COCH-ARM / FISHERS |                                                        |P=0.044 *    P=0.500      (e)          P=0.122      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/60 (3%)    2/60 (3%)    2/60 (3%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/56.38      2/54.01      2/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |                                                        |3.6%         3.7%         3.5%         0.0%         | 
|TERMINAL (d)       |                                                        |1/52 (2%)    2/46 (4%)    2/47 (4%)    0/5 (0%)     | 
|FIRST INCIDENCE    |                                                        |710          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.588N     P=0.649      P=0.655      P=0.728N     | 
|POLY 3             |                                                        |P=0.250N     P=0.678      P=0.688N     P=0.323N     | 
|POLY 1.5           |                                                        |P=0.208N     P=0.683      P=0.687N     P=0.280N     | 
|POLY 6             |                                                        |P=0.338N     P=0.670      P=0.692      P=0.396N     | 
|LOGISTIC REGRESSION|                                                        |P=0.453N     P=0.673      P=0.694      P=0.509N     | 
|COCH-ARM / FISHERS |                                                        |P=0.164N     P=0.691N     P=0.691N     P=0.248N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    1/60 (2%)    1/60 (2%)    0/60 (0%)   |3/60 (5%)    2/60 (3%)    0/60 (0%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/56.99      1/49.65      1/23.78      0/9.13      |3/56.31      2/54.01      0/57.18      0/39.77      | 
|POLY-3 PERCENT (g) |     1.8%         2.0%         4.2%         0.0%        |5.3%         3.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    1/34 (3%)    0/0 (0%)     0/0 (0%)    |3/52 (6%)    2/46 (4%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      645          ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198      P=0.664      P=0.006 **   P=1.000N    |P=0.140N     P=0.556N     P=0.140N     P=0.689N     | 
|POLY 3             |     P=0.580      P=0.729      P=0.547      P=0.721N    |P=0.043N*    P=0.519N     P=0.117N     P=0.195N     | 
|POLY 1.5           |     P=0.571N     P=0.743      P=0.650      P=0.654N    |P=0.042N*    P=0.512N     P=0.117N     P=0.155N     | 
|POLY 6             |     P=0.573      P=0.711      P=0.420      P=0.754N    |P=0.048N*    P=0.528N     P=0.120N     P=0.272N     | 
|LOGISTIC REGRESSION|     P=0.472      P=0.664      P=0.410      (e)         |P=0.140N     P=0.556N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.312N     P=0.752N     P=0.752N     P=0.500N    |P=0.039N*    P=0.500N     P=0.122N     P=0.122N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/60 (7%)    17/60 (28%)  55/60 (92%)  60/60 (100%)|0/60 (0%)    2/60 (3%)    3/60 (5%)    50/60 (83%)  | 
|POLY-3 RATE (b)    |     4/57.07      17/51.92     55/56.21     60/60.00    |0/56.31      2/54.90      3/57.56      50/55.42     | 
|POLY-3 PERCENT (g) |     7.0%         32.7%        97.9%        100.0%      |0.0%         3.6%         5.2%         90.2%        | 
|TERMINAL (d)       |     3/52 (6%)    9/34 (27%)   0/0 (0%)     0/0 (0%)    |0/52 (0%)    1/46 (2%)    2/47 (4%)    4/5 (80%)    | 
|FIRST INCIDENCE    |     710          542          365          277         |---          343          624          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.224      P=0.114      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.232      P=0.124      P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.234      P=0.124      P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.228      P=0.122      P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.284      P=0.107      P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.248      P=0.122      P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/60 (8%)    18/60 (30%)  55/60 (92%)  60/60 (100%)|3/60 (5%)    4/60 (7%)    3/60 (5%)    50/60 (83%)  | 
|POLY-3 RATE (b)    |     5/57.07      18/51.92     55/56.21     60/60.00    |3/56.31      4/54.90      3/57.56      50/55.42     | 
|POLY-3 PERCENT (g) |     8.8%         34.7%        97.9%        100.0%      |5.3%         7.3%         5.2%         90.2%        | 
|TERMINAL (d)       |     4/52 (8%)    10/34 (29%)  0/0 (0%)     0/0 (0%)    |3/52 (6%)    3/46 (7%)    2/47 (4%)    4/5 (80%)    | 
|FIRST INCIDENCE    |     710          542          365          277         |729 (T)      343          624          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.442      P=0.626      P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.486      P=0.651N     P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.492      P=0.652N     P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.477      P=0.657N     P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.521      P=0.662N     P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.500      P=0.660N     P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/60 (2%)    1/60 (2%)    0/60 (0%)    0/60 (0%)   |0/60 (0%)    2/60 (3%)    1/60 (2%)    0/60 (0%)    | 
|POLY-3 RATE (b)    |     1/56.99      1/49.66      0/23.48      0/9.13      |0/56.31      2/54.53      1/57.29      0/39.77      | 
|POLY-3 PERCENT (g) |     1.8%         2.0%         0.0%         0.0%        |0.0%         3.7%         1.8%         0.0%         | 
|TERMINAL (d)       |     1/52 (2%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |0/52 (0%)    0/46 (0%)    0/47 (0%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      726          ---          ---         |---          658          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.877      P=0.670      P=1.000N     P=1.000N    |P=0.675N     P=0.225      P=0.489      (e)          | 
|POLY 3             |     P=0.604N     P=0.729      P=0.650N     P=0.721N    |P=0.564N     P=0.231      P=0.503      (e)          | 
|POLY 1.5           |     P=0.367N     P=0.743      P=0.587N     P=0.654N    |P=0.517N     P=0.233      P=0.504      (e)          | 
|POLY 6             |     P=0.799      P=0.711      P=0.714N     P=0.754N    |P=0.562      P=0.228      P=0.501      (e)          | 
|LOGISTIC REGRESSION|     P=0.890      P=0.689      (e)          (e)         |P=0.432N     P=0.250      P=0.493      (e)          | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.752N     P=0.500N     P=0.500N    |P=0.461N     P=0.248      P=0.500      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/60 (5%)    0/60 (0%)    1/60 (2%)    0/60 (0%)   |8/60 (13%)   7/60 (12%)   5/60 (8%)    3/60 (5%)    | 
|POLY-3 RATE (b)    |     3/56.99      0/49.65      1/24.27      0/9.13      |8/56.32      7/55.37      5/57.46      3/40.41      | 
|POLY-3 PERCENT (g) |     5.3%         0.0%         4.1%         0.0%        |14.2%        12.6%        8.7%         7.4%         | 
|TERMINAL (d)       |     3/52 (6%)    0/34 (0%)    0/0 (0%)     0/0 (0%)    |7/52 (14%)   5/46 (11%)   3/47 (6%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          434          ---         |725          266          671          661          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.734N     P=0.206N     P=0.482      P=1.000N    |P=0.412      P=0.587N     P=0.344N     P=0.190      | 
|POLY 3             |     P=0.220N     P=0.146N     P=0.614N     P=0.533N    |P=0.148N     P=0.514N     P=0.266N     P=0.244N     | 
|POLY 1.5           |     P=0.154N     P=0.134N     P=0.474N     P=0.350N    |P=0.105N     P=0.507N     P=0.267N     P=0.166N     | 
|POLY 6             |     P=0.219N     P=0.163N     P=0.561      P=0.641N    |P=0.225N     P=0.526N     P=0.273N     P=0.399N     | 
|LOGISTIC REGRESSION|     P=0.168N     (e)          P=0.556N     (e)         |P=0.072N     P=0.488N     P=0.275N     P=0.572N     | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.122N     P=0.309N     P=0.122N    |P=0.064N     P=0.500N     P=0.279N     P=0.102N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/60 (50%)  24/60 (40%)  8/60 (13%)   2/60 (3%)   |21/60 (35%)  20/60 (33%)  26/60 (43%)  33/60 (55%)  | 
|POLY-3 RATE (b)    |     30/57.33     24/53.03     8/27.98      2/10.78     |21/57.78     20/54.32     26/57.66     33/48.17     | 
|POLY-3 PERCENT (g) |     52.3%        45.3%        28.6%        18.6%       |36.4%        36.8%        45.1%        68.5%        | 
|TERMINAL (d)       |     29/52 (56%)  17/34 (50%)  0/0 (0%)     0/0 (0%)    |18/52 (35%)  19/46 (41%)  23/47 (49%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     637          451          434          391         |299          644          673          516          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.273      P<0.001 **   P=0.037 *   |P<0.001 **   P=0.473      P=0.131      P<0.001 **   | 
|POLY 3             |     P=0.016N*    P=0.288N     P=0.040N*    P=0.137N    |P<0.001 **   P=0.557      P=0.221      P<0.001 **   | 
|POLY 1.5           |     P<0.001N**   P=0.234N     P<0.001N**   P<0.001N**  |P<0.001 **   P=0.566N     P=0.230      P=0.003 **   | 
|POLY 6             |     P=0.331N     P=0.367N     P=0.467N     P=0.553     |P<0.001 **   P=0.521      P=0.199      P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.088N     P=0.320N     P=0.534N     P=0.763     |P<0.001 **   P=0.539N     P=0.237      P=0.003 **   | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.179N     P<0.001N**   P<0.001N**  |P=0.007 **   P=0.500N     P=0.227      P=0.022 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  11/16/00                           EXPERIMENT: 05203 TEST: 09                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   O-NITROTOLUENE                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/60 (43%)  41/60 (68%)  59/60 (98%)  60/60 (100%)|16/60 (27%)  23/60 (38%)  27/60 (45%)  55/60 (92%)  | 
|POLY-3 RATE (b)    |     26/58.58     41/57.74     59/59.07     60/60.00    |16/57.28     23/58.53     27/59.79     55/57.22     | 
|POLY-3 PERCENT (g) |     44.4%        71.0%        99.9%        100.0%      |27.9%        39.3%        45.2%        96.1%        | 
|TERMINAL (d)       |     20/52 (39%)  19/34 (56%)  0/0 (0%)     0/0 (0%)    |13/52 (25%)  14/46 (30%)  15/47 (32%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     596          451          270          277         |362          266          553          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.079      P=0.025 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.136      P=0.039 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.130      P=0.035 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.142      P=0.044 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.009 **   P<0.001 **   P=0.006 **  |P<0.001 **   P=0.147      P=0.022 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.121      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        1250 PPM     2500 PPM     5000 PPM    |0 PPM        1250 PPM     2500 PPM     5000 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/60 (75%)  50/60 (83%)  59/60 (98%)  60/60 (100%)|33/60 (55%)  37/60 (62%)  44/60 (73%)  56/60 (93%)  | 
|POLY-3 RATE (b)    |     45/58.58     50/58.48     59/59.07     60/60.00    |33/58.67     37/58.53     44/60.00     56/57.38     | 
|POLY-3 PERCENT (g) |     76.8%        85.5%        99.9%        100.0%      |56.2%        63.2%        73.3%        97.6%        | 
|TERMINAL (d)       |     39/52 (75%)  27/34 (79%)  0/0 (0%)     0/0 (0%)    |28/52 (54%)  28/46 (61%)  31/47 (66%)  5/5 (100%)   | 
|FIRST INCIDENCE    |     596          451          270          277         |299          266          553          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.137      P=0.021 *    P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.164      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.281      P=0.038 *    P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.177      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.280      P=0.033 *    P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.149      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.283      P=0.043 *    P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.143      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.316      P=0.024 *    P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.184      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.289      P=0.028 *    P<0.001 **   | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
                                                                                                                                   
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).