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TDMS Study 05203-09 Pathology Tables

NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00
Route: DOSED FEED                                                                                                 Time: 10:17:16

                                                         MICE, FINAL#1




       Facility:  Southern Research Institute

       Chemical CAS #:  88-72-2

       Lock Date:  03/08/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































Note:  Animals arranged according to days on test

                                                              Page   1


NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|             
                                           | 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  A  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X                          X                                          |             
      Hepatocellular Adenoma               |                                                       X              X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +        +           +                              |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Squamous Cell Papilloma              |             X                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|             
                                           | 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
      Pars Distalis, Adenoma               |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                       X                  |             
      Luteoma                              |                                                                X         |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Endometrium, Polyp Stromal           |                   X                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|             
                                           | 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                       +                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma       |                                        X  X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 6| 8| 6| 9| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 2| 3| 2| 2| 0| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 8| 9| 9| 8| 6| 4| 5| 8| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 4| 4| 4| 4|             
                                           | 6| 9| 5| 8| 3| 5| 1| 1| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pleura                                  |       +                                                                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                      A     +     +  +                                    |             
      Adenoma                              |                            X     X                                       |             
      Carcinoma                            |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                      X     X                 X                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|             
                                           | 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |             X     X     X     X                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +        +  +     +                                   +     +|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |          X                                                               |             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +           +                          +                 +     +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|             
                                           | 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Pars Distalis, Adenoma               |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Luteoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                               +                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|             
                                           | 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                               +              +                    +      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +|             
      Sarcoma                              |                                                                X         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
      Hemangioma                           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                 X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2|             
    0 PPM                                  | 5| 5| 5| 5| 5| 8| 8| 8| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 9| 9| 9| 0| 7| 7|             
                                           | 0| 2| 3| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Adenoma                              |                                           X                              |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X              X                    X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0 PPM                                  | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     L      |
                                           | 8| 9| 0| 7| 9| 0| 1| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
      Hepatocellular Adenoma               |                         X                                                |          7 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +              +                                                      |  11        |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangioma                           |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0 PPM                                  | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     L      |
                                           | 8| 9| 0| 7| 9| 0| 1| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                                                                        |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Capsule, Adenoma                     |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Adenoma                              |                                                                          |          1 |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0 PPM                                  | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     L      |
                                           | 8| 9| 0| 7| 9| 0| 1| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cystadenoma                          |                                                                          |          1 |
      Luteoma                              |                   X                                                      |          2 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangioma                           |                         X                                                |          1 |
      Endometrium, Polyp Stromal           |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   6        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  M  +  +                                             |  53        |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  I  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0 PPM                                  | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     L      |
                                           | 8| 9| 0| 7| 9| 0| 1| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemangioma                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  M  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   5        |
      Adenoma                              |    X                                                                     |          4 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    0 PPM                                  | 7| 7| 8| 8| 8| 9| 9| 9| 9| 9|                                            |     L      |
                                           | 8| 9| 0| 7| 9| 0| 1| 2| 3| 4|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant                   |    X  X                                                                  |          8 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|             
                                           | 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  +  A  +  +  A  +  M  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  A  +  +  A  +  A  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  A  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  A  +  +  A  +  A  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  +  A  +  A  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                                                       X     X            |             
      Histiocytic Sarcoma                  |                         X  X                                             |             
      Osteosarcoma, Metastatic, Bone       |          X                                                               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +     +        +                          +  +              +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |             X                                                            |             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                      X   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|             
                                           | 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Stomach, Glandular                      | A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|             
                                           | 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | A  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
      Hemangiosarcoma                      |       X                                                                  |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Tubulostromal Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                   X      |             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Leiomyoma                            |                                                                          |             
      Endometrium, Polyp Stromal           |                                              X                           |             
                                           |__________________________________________________________________________|             
   Vagina                                  |             +                                                            |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |             X                                                            |             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | A  +  +  +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Spleen                                  | A  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|             
                                           | 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant         |                               X                                          |             
      Subcutaneous Tissue, Carcinoma,      |                                                                          |             
          Multiple                         |             X                                                            |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |          X                                                               |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |             +                             +                          +   |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |             X                                                            |             
      Sarcoma                              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +     +                                                               |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +     +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |             X                                                            |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                      X                                                   |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 4| 9| 5| 0| 1| 4| 5| 6| 7| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 2| 3| 7| 3| 8| 2| 4| 8| 0| 9| 2| 1| 3| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 3| 5| 5| 4| 4| 3| 1| 0| 0| 3| 2| 0| 4| 0| 0| 0| 0| 0| 0| 1| 4| 4| 4| 4| 4|             
                                           | 9| 9| 3| 9| 8| 6| 2| 8| 1| 2| 9| 7| 0| 4| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Primary Site                     |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Histiocytic Sarcoma                  |                         X                                                |             
      Osteosarcoma, Metastatic, Bone       |          X                                                               |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                      X                                                   |             
      Mediastinum, Carcinoma               |             X                                                            |             
      Mediastinum, Carcinoma, Metastatic,  |                                                                          |             
           Harderian Gland                 |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
      Carcinoma                            |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | A  +  A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |             X                                                            |             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  A  M  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                         X  X                                             |             
      Lymphoma Malignant                   | X                 X                                X  X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                  X                       X               |             
      Hepatocellular Carcinoma, Multiple   | X                                                                        |             
      Hepatocellular Adenoma               |                      X     X           X                                 |             
      Histiocytic Sarcoma                  |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |    X                                                                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                    +                          +                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                     X                          X         |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Tubulostromal Adenoma                |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                          X               |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyoma                            |                                              X                           |             
      Endometrium, Polyp Stromal           |             X                                                            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                +         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant         |                                                                          |             
      Subcutaneous Tissue, Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |          X                                                               |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 5| 5| 5| 5| 1| 1| 1| 1| 2| 2| 2| 2| 3| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3|             
                                           | 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 0| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Primary Site                     |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           | X                                                                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinum, Carcinoma               |                                                                          |             
      Mediastinum, Carcinoma, Metastatic,  |                                                                          |             
           Harderian Gland                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                X         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Carcinoma                            |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hepatocellular Carcinoma             |                      X                                                   |          3 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          5 |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                +        +                                                |   9        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Carcinoma                            |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Adenoma               |    X                                                                     |          4 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Carcinoma                            |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Tubulostromal Adenoma                |                X                                                         |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangioma                           |          X                                                               |          2 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyoma                            |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basosquamous Tumor Malignant         |                                                                          |          1 |
      Subcutaneous Tissue, Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Osteosarcoma                         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          3 |
      Alveolar/Bronchiolar Carcinoma       |    X                                                                     |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Carcinoma               |                                                                          |          1 |
      Mediastinum, Carcinoma, Metastatic,  |                                                                          |            |
           Harderian Gland                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    1250 PPM                               | 3| 3| 3| 4| 4| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 5| 7| 8| 6| 7| 0| 6| 7| 8| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Carcinoma                            |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  54        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          2 |
      Lymphoma Malignant                   | X                       X                                                |          7 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    2500 PPM                               | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|             
                                           | 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  A  +  +  +  A  A  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  M  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                     X     X                              |             
      Sarcoma                              |                X                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |          X                       X                                       |             
      Hepatocellular Carcinoma, Multiple   |                                                       X                  |             
      Hepatocellular Adenoma               |                   X  X                          X           X        X   |             
      Hepatocellular Adenoma, Multiple     |                                              X                           |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                X                                                         |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +     +        +              +           +                 +            |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                           X                              |             
      Sarcoma, Multiple                    |                X                                                         |             
      Sarcoma, Metastatic, Skin            |                               X                                          |             
      Sarcoma, Metastatic, Skeletal Muscle | X                                                                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    2500 PPM                               | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|             
                                           | 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Sarcoma                              |                X                                                         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                        X                          X      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                 X  X                     |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    2500 PPM                               | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|             
                                           | 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Cystadenoma                          |                                                                          |             
      Luteoma                              |                                                                      X   |             
      Teratoma Malignant                   |                                                                         X|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Leiomyosarcoma                       |                                                                          |             
      Endometrium, Carcinoma               |                         X                                                |             
      Endometrium, Polyp Stromal           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +     +  +              +     +     +                              |             
      Inguinal, Sarcoma, Metastatic, Skin  |                               X                                          |             
      Pancreatic, Sarcoma                  |                X                                                         |             
      Renal, Sarcoma, Metastatic, Skin     |                               X                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  +  +  A  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    2500 PPM                               | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|             
                                           | 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |       X                                X                                 |             
      Subcutaneous Tissue, Sarcoma         |          X           X        X                                   X      |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosarcoma                  |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +              +                 +                                       |             
      Sarcoma                              | X                                X                                       |             
      Sarcoma, Multiple                    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +        +                                                      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |          +        +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                                         X   |             
      Histiocytic Sarcoma                  |                            X                                             |             
      Osteosarcoma, Metastatic, Bone       |    X                                                                     |             
      Sarcoma, Metastatic, Skeletal Muscle | X                                                                        |             
      Teratoma Malignant, Metastatic, Ovary|                                                                         X|             
      Mediastinum, Histiocytic Sarcoma     |                            X                                             |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 2| 6| 7| 7| 7| 9| 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 8| 4| 1| 1| 2| 3| 0| 1| 1| 9| 0| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 3| 3| 3| 3| 4| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    2500 PPM                               | 1| 6| 7| 8| 9| 1| 2| 6| 6| 8| 0| 7| 7| 6| 6| 6| 9| 9| 9| 9| 0| 0| 0| 0| 1|             
                                           | 3| 4| 5| 2| 5| 9| 0| 8| 3| 5| 2| 0| 3| 6| 7| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Uncertain Primary Site          |                X                                                         |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 | X                                                                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                X                                                         |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                            X                                             |             
      Lymphoma Malignant                   |             X                       X     X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |          X                 X                                             |             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             |             X                                                            |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |    X              X        X     X        X  X           X     X     X   |             
      Hepatocellular Adenoma, Multiple     | X                                                                        |             
      Histiocytic Sarcoma                  |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                        +        +        +               |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                                          |             
      Sarcoma, Multiple                    |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  M  M  +  +  +  +|             
      Pars Distalis, Adenoma               |                                              X                           |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                            X                                             |             
      Luteoma                              |                                                                          |             
      Teratoma Malignant                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Endometrium, Carcinoma               |                                                                          |             
      Endometrium, Polyp Stromal           |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                       +        +                        |             
      Inguinal, Sarcoma, Metastatic, Skin  |                                                                          |             
      Pancreatic, Sarcoma                  |                                                                          |             
      Renal, Sarcoma, Metastatic, Skin     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |       X                                                                  |             
      Subcutaneous Tissue, Sarcoma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Multiple                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |             
      Teratoma Malignant, Metastatic, Ovary|                                                                          |             
      Mediastinum, Histiocytic Sarcoma     |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 7| 7| 7| 7| 7| 7| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
                                           | 1| 2| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 6| 7| 8| 9| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                            +           +     +                           |             
      Adenoma                              |                                        X                                 |             
      Carcinoma                            |                            X                 X                           |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                              X  X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +                                             |  54        |
      Carcinoma                            |                                                                          |          4 |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Hepatocellular Carcinoma             |                X                                                         |          4 |
      Hepatocellular Carcinoma, Multiple   |                            X                                             |          2 |
      Hepatocellular Adenoma               |             X        X                                                   |         16 |
      Hepatocellular Adenoma, Multiple     |                            X                                             |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
          Large, Cecum                     |                                                                          |          1 |
      Sarcoma, Multiple                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |                                                                          |          3 |
      Pars Intermedia, Adenoma             |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  I  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Cystadenoma                          |                      X                                                   |          2 |
      Luteoma                              |                                                                          |          1 |
      Teratoma Malignant                   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leiomyosarcoma                       |                      X                                                   |          1 |
      Endometrium, Carcinoma               |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +                                                   |  10        |
      Inguinal, Sarcoma, Metastatic, Skin  |                                                                          |          1 |
      Pancreatic, Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Sarcoma, Metastatic, Skin     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  I  M  +  +  +  +  +                                             |  55        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Thymoma Malignant                    |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          2 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          5 |
      Subcutaneous Tissue, Sarcoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Osteosarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Sarcoma                              |                                                                          |          2 |
      Sarcoma, Multiple                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alveolar/Bronchiolar Adenoma         |                            X                                             |          4 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Sarcoma, Metastatic, Skeletal Muscle |                                                                          |          1 |
      Teratoma Malignant, Metastatic, Ovary|                                                                          |          1 |
      Mediastinum, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Mediastinum, Sarcoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 4| 3| 3| 3| 4| 4| 4|                                            |     A      |
    2500 PPM                               | 9| 9| 9| 0| 6| 6| 6| 1| 1| 1|                                            |     L      |
                                           | 7| 8| 9| 0| 1| 2| 5| 6| 7| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  M  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|             
                                           | 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|             
                                           | 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  A  A  +  +  +  M  +  A  A  A  +  +  +  +  A  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  A  +  A  A  +  +  +  +  +  A  +  A  +  +  A|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  A  +  +  A  +  A  +  A  A  +  +  +  +  +  A  A  A  +  +  A|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  A  +  A  A  +  +  +  +  +  A  A  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  +  +  A  +  A  A  +  +  +  +  +  A  A  A  +  +  A|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  A  +  +  +  +  A  +  A  A  +  +  +  +  +  A  A  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hepatocellular Carcinoma             |                               X        X  X           X        X         |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                            X  X        X        X              X  X     X|             
      Hepatocellular Adenoma, Multiple     |                                                             X            |             
      Hepatocholangiocarcinoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +  +  +              +  +  +     +  +  +  +  +     +     +|             
      Hemangiosarcoma                      |                X  X                       X        X  X     X     X     X|             
      Hemangiosarcoma, Multiple            |                                     X  X                 X               |             
      Sarcoma                              |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|             
                                           | 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|             
                                           | 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Mesentery                        |                X                                                         |             
      Sarcoma, Metastatic, Mesentery       |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
      Abdominal, Hemangiosarcoma           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|             
                                           | 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|             
                                           | 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Abdominal, Hemangiosarcoma, Multiple |                                                                X         |             
      Thoracic, Sarcoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Cervix, Hemangiosarcoma              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                        +  +  +  +                        |             
      Iliac, Sarcoma, Metastatic, Skin     |                                                                          |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                                 X                        |             
      Renal, Hemangiosarcoma, Metastatic,  |                                                                          |             
           Mesentery                       |                                           X                              |             
      Renal, Sarcoma, Metastatic, Skin     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  M  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  I  +  +  +  A  +  +  M  M  +  +  M  +  I  I  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|             
                                           | 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|             
                                           | 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |    X                                                              X  X   |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +                 +  +                    +                    +   |             
      Hemangiosarcoma                      |       X                    X                                         X   |             
      Hemangiosarcoma, Multiple            |                         X                                                |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Multiple                    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +                       +                                   +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |          +                       +                                   +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |             X                                                            |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 0| 0| 4| 4| 8| 0| 1| 2| 4| 6| 6| 6| 7| 7| 8| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1|             
                                           | 3| 9| 4| 4| 8| 7| 6| 2| 8| 7| 7| 9| 5| 9| 1| 3| 3| 8| 0| 7| 5| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 3| 6| 4| 5| 2| 3| 6| 4| 6| 2| 5| 6| 3| 7| 2| 2| 3| 2| 2| 5| 7| 3| 2| 4| 8|             
                                           | 1| 7| 1| 0| 6| 6| 1| 4| 4| 9| 5| 5| 0| 4| 3| 8| 4| 5| 7| 2| 1| 9| 1| 3| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                                      X   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|             
                                           | 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  A  A  A  A  A  A  A  +  A  A  A  A  A  A  +  A  M  A  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  A  A  A  +  A  +  +  +  +  +  +  A  A  +  A  +  A  +  +  +  +  A|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  A  A  A  A  A  A  A  +  A  A  A  A  +  A  +  A  +  A  +  +  +  +  A|             
      Carcinoma                            | X                                         X                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  A  A  A  A  A  A  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  A  A  A  A  A  A  +  +  A  A  +  A  A  +  A  +  A  +  +  +  +  A|             
      Carcinoma                            |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  A  A  A  A  A  A  +  +  A  A  +  A  +  A  A  +  A  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangioma                          |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                        X                                 |             
      Hepatocellular Carcinoma             | X        X                                                               |             
      Hepatocellular Carcinoma, Multiple   |             X           X              X                    X            |             
      Hepatocellular Adenoma               |                                                          X              X|             
      Hepatocellular Adenoma, Multiple     |    X  X  X        X        X  X     X           X     X        X  X  X   |             
      Hepatocholangiocarcinoma             |                                           X                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +  +     +  +  +  +        +  +     +  +     +           +  +  +  +|             
      Hemangiosarcoma                      |       X  X     X  X  X  X                 X  X                 X  X  X  X|             
      Hemangiosarcoma, Multiple            |                                  X  X              X                     |             
      Sarcoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|             
                                           | 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Mesentery                        |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  M  +  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                             X            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |          +                                                           +   |             
      Abdominal, Hemangiosarcoma           |          X                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|             
                                           | 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
      Abdominal, Hemangiosarcoma, Multiple |                                                                          |             
      Thoracic, Sarcoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +|             
      Luteoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                         X                     |             
      Cervix, Hemangiosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +  +                       +                 +              +      |             
      Iliac, Sarcoma, Metastatic, Skin     |                                                                          |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                                                          |             
      Renal, Hemangiosarcoma, Metastatic,  |                                                                          |             
           Mesentery                       |                                                                          |             
      Renal, Sarcoma, Metastatic, Skin     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|             
                                           | 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                   X      |             
      Subcutaneous Tissue, Hemangiosarcoma | X                 X                 X  X     X  X           X  X         |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                                  X        X                       X      |             
      Subcutaneous Tissue, Sarcoma         |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +     +  +     +        +  +                    +  +     +            |             
      Hemangiosarcoma                      | X  X     X  X              X  X                    X  X     X            |             
      Hemangiosarcoma, Multiple            |                   X                                                      |             
      Sarcoma                              |                                                                          |             
      Sarcoma, Multiple                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Alveolar/Bronchiolar Adenoma         | X                                      X                             X   |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                    X                     |             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 1| 2| 2| 3| 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 9| 4| 9| 0| 0| 3| 7| 8| 9| 1| 1| 8| 9| 1| 5| 7| 9| 5| 6| 6| 8| 0| 0| 3| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5000 PPM                               | 6| 5| 5| 3| 2| 7| 3| 5| 2| 4| 5| 3| 5| 3| 4| 6| 5| 4| 7| 7| 4| 6| 7| 6| 4|             
                                           | 9| 7| 3| 3| 4| 8| 8| 6| 2| 8| 8| 5| 1| 2| 7| 8| 4| 9| 0| 2| 5| 3| 9| 6| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                        X                                 |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                           X                              |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +|             
      Hemangiosarcoma                      |          X                                                               |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                               X  X                                X      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  A  +  +  +  +  +  +                                             |  31        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  A  +  +  +  +  +  +                                             |  41        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  A  +  +  +  +  +  +                                             |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +                                             |  32        |
      Carcinoma                            |                X                                                         |          3 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  +  +                                             |  34        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +                                             |  34        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +                                             |  34        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cholangioma                          |                X                                                         |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hepatocellular Carcinoma             | X                       X                                                |          9 |
      Hepatocellular Carcinoma, Multiple   |    X  X     X                                                            |          7 |
      Hepatocellular Adenoma               |                                                                          |          9 |
      Hepatocellular Adenoma, Multiple     |          X  X  X  X  X  X  X                                             |         20 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +        +  +  +  +                                             |  34        |
      Hemangiosarcoma                      | X                 X  X  X  X                                             |         25 |
      Hemangiosarcoma, Multiple            |          X                                                               |          7 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  52        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +        +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +                                             |  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  53        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Abdominal, Hemangiosarcoma           |                                                                          |          1 |
      Abdominal, Hemangiosarcoma, Multiple |                                                                          |          1 |
      Thoracic, Sarcoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Luteoma                              |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Cervix, Hemangiosarcoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +                                                                  |  11        |
      Iliac, Sarcoma, Metastatic, Skin     |       X                                                                  |          1 |
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Renal, Hemangiosarcoma, Metastatic,  |                                                                          |            |
           Mesentery                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Sarcoma, Metastatic, Skin     |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  I  +  +  +  +  +  +                                             |  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |    X     X  X     X     X                                                |         16 |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Multiple                        |                                                                          |          3 |
      Subcutaneous Tissue, Sarcoma         |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +     +  +                                                               |  18        |
      Hemangiosarcoma                      | X        X                                                               |         14 |
      Hemangiosarcoma, Multiple            |                                                                          |          2 |
      Sarcoma                              |       X                                                                  |          1 |
      Sarcoma, Multiple                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          4 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                         X                                                |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |    X                                                                     |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                         +  +                                             |   4        |
      Adenoma                              |                            X                                             |          2 |
      Carcinoma                            |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 1| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 2| 0| 0| 2| 5| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    5000 PPM                               | 4| 5| 6| 6| 3| 4| 7| 7| 7| 7|                                            |     L      |
                                           | 2| 9| 0| 2| 7| 6| 3| 5| 6| 7|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hemangiosarcoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant                   |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|             
                                           | 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  M  M  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                    X                     |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                   X      |             
      Hepatoblastoma                       |                      X                                                   |             
      Hepatocellular Carcinoma             |       X     X  X                             X           X               |             
      Hepatocellular Carcinoma, Multiple   |          X        X                                                  X   |             
      Hepatocellular Adenoma               |             X                       X  X     X  X           X            |             
      Hepatocellular Adenoma, Multiple     |                                           X                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +                    +     +           +  +                    +      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|             
                                           | 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +              +        +     +                    +        +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Capsule, Adenoma                     |                               X                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                +  +                                                      |             
      Thoracic, Sarcoma                    |                   X                                                      |             
      Thoracic, Sarcoma, Multiple          |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|             
                                           | 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +  +                                                   |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Tissue NOS                      |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                   X                             X                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|             
                                           | 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +                                                                        |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +                                                        +               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                               X              X                 X        X|             
      Alveolar/Bronchiolar Carcinoma       |                            X                          X                  |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                X                          X                              |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                              +                           |             
      External Ear, Neural Crest Tumor,    |                                                                          |             
           Malignant                       |                                              X                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 9| 9| 1| 3| 4| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 3| 2| 6| 8| 7| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 2| 5| 1| 1| 3| 4| 2| 5| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4|             
                                           | 4| 3| 9| 8| 1| 3| 3| 4| 1| 3| 4| 8| 9| 5| 6| 1| 2| 7| 9| 2| 4| 7| 0| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Kidney                                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                            X                          X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                   X      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |          X  X        X                                                   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |             X                             X                 X  X  X     X|             
      Hepatocellular Adenoma, Multiple     |                         X                                            X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +  +                          +                 +   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +           +        +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Capsule, Adenoma                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                          X               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thoracic, Sarcoma                    |                                                                          |             
      Thoracic, Sarcoma, Multiple          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |                                                                X         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                    +                     |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Tissue NOS                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                X         |             
      Hemangiosarcoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                   X                  |             
      Alveolar/Bronchiolar Carcinoma       |                X                                                         |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
      External Ear, Neural Crest Tumor,    |                                                                          |             
           Malignant                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                     +     +        +                     |             
      Adenoma                              |                                           X        X                     |             
      Carcinoma                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 4| 4| 5| 5| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4|             
                                           | 6| 9| 2| 7| 5| 6| 7| 0| 1| 2| 3| 4| 7| 0| 5| 6| 8| 3| 5| 6| 8| 9| 1| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                    X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 PPM                                  | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5|                                            |     L      |
                                           | 8| 5| 6| 8| 0| 2| 0| 0| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  I  +  +  +  +  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Adenocarcinoma                       |                                                                          |          1 |
      Carcinoma                            |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |          X                                                               |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          3 |
      Hepatocellular Adenoma               |       X     X  X                                                         |         15 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |  12        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 PPM                                  | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5|                                            |     L      |
                                           | 8| 5| 6| 8| 0| 2| 0| 0| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +           +  +  +  +                                             |  14        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Adenoma                              |                                                                          |          1 |
      Capsule, Adenoma                     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +                                             |  53        |
      Pars Distalis, Adenoma               |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 PPM                                  | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5|                                            |     L      |
                                           | 8| 5| 6| 8| 0| 2| 0| 0| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
      Thoracic, Sarcoma                    |                                                                          |          1 |
      Thoracic, Sarcoma, Multiple          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |            |
           Tissue NOS                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangioma                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 PPM                                  | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5|                                            |     L      |
                                           | 8| 5| 6| 8| 0| 2| 0| 0| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma                      |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |    X              X  X                                                   |          9 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 PPM                                  | 4| 5| 5| 5| 6| 0| 3| 5| 5| 5|                                            |     L      |
                                           | 8| 5| 6| 8| 0| 2| 0| 0| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      External Ear, Neural Crest Tumor,    |                                                                          |            |
           Malignant                       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                            +                                             |   5        |
      Adenoma                              |                            X                                             |          4 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
      Lymphoma Malignant                   |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|             
                                           | 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|             
    1250 PPM                               | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|             
                                           | 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  A  A  A  +  +  +  A  A  A  M  +  +  +  A  M  A  A  A  A  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  A  +  M  +  A  A  +  +  M  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  M  +  +  M  A  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  A  A  +  +  A  +  +  +  +  A  A  +  A  A  +  +  +  +  A  A|             
      Carcinoma                            |             X        X  X     X     X                    X     X  X      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  A  +  A  +  A  A  +  A  +  +  +  A  A  +  A  A  +  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  A  +  A  A  A  +  A  A  +  +  A  A  A  A  A  A  +  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  A  +  A  +  A  A  A  A  +  +  A  A  A  A  A  A  +  +  A  +  A  A|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Hemangiosarcoma, Multiple            |                                              X                           |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             | X                                      X           X                 X  X|             
      Hepatocellular Carcinoma, Multiple   |                                                                   X      |             
      Hepatocellular Adenoma               | X                       X                 X     X                        |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +                       +     +  +        +   |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                          X               |             
      Hemangiosarcoma                      |                            X                       X                 X   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                  +                                       |             
      Pharyngeal, Squamous Cell Carcinoma  |                                  X                                       |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|             
                                           | 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|             
    1250 PPM                               | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|             
                                           | 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  M  +  M  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Carcinoma                    |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|             
                                           | 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|             
    1250 PPM                               | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|             
                                           | 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                          +     +        +|             
      Pancreatic, Histiocytic Sarcoma      |                                                                         X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                     X                                    |             
      Histiocytic Sarcoma                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                              X                       X   |             
      Histiocytic Sarcoma                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|             
                                           | 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|             
    1250 PPM                               | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|             
                                           | 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Hemangioma      |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                   X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteoma                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                   +        +              +           +                  |             
      Hemangiosarcoma                      |                   X        X              X           X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X                 X                                   X         |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                          X               |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                   X                                                      |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                        X                                 |             
      Histiocytic Sarcoma                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 6| 6| 6| 8| 2| 4| 4| 5| 7| 7| 9| 0| 3| 3| 4| 4| 5| 8| 8| 9| 9| 1| 1| 2|             
                                           | 1| 0| 3| 9| 5| 6| 2| 5| 9| 2| 5| 2| 4| 0| 3| 1| 1| 5| 6| 8| 0| 0| 0| 7| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| 0| 1| 1| 0| 1| 0| 0| 0|             
    1250 PPM                               | 1| 0| 2| 8| 8| 9| 6| 7| 6| 7| 9| 0| 8| 6| 7| 7| 9| 6| 1| 0| 9| 1| 7| 8| 8|             
                                           | 9| 3| 0| 7| 0| 0| 3| 7| 6| 6| 8| 1| 6| 9| 0| 1| 1| 8| 0| 5| 7| 4| 3| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                         X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1250 PPM                               | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|             
                                           | 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |          X                                X              X           X   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Carcinoma                            |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            | X                          X                                             |             
      Hepatoblastoma                       | X                                                                        |             
      Hepatocellular Carcinoma             |    X                                            X     X  X               |             
      Hepatocellular Carcinoma, Multiple   |                                  X  X                       X            |             
      Hepatocellular Adenoma               |       X        X                 X     X  X                             X|             
      Hepatocellular Adenoma, Multiple     |             X                 X     X                 X     X        X   |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +           +     +                       +              +      |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                                          |             
      Hemangiosarcoma                      |                      X     X                       X              X      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Squamous Cell Carcinoma  |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1250 PPM                               | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|             
                                           | 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +                                         +  +        +     +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1250 PPM                               | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|             
                                           | 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                            X                                             |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1250 PPM                               | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|             
                                           | 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                                       X                  |             
      Subcutaneous Tissue, Hemangioma      |                                                                X         |             
      Subcutaneous Tissue, Hemangiosarcoma |    X                       X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteoma                     |                                                                         X|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                 +                                                      |             
      Hemangiosarcoma                      | X                 X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X        X                                                   |             
      Alveolar/Bronchiolar Carcinoma       |                               X                                          |             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                          X               |             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    1250 PPM                               | 6| 6| 7| 8| 8| 8| 9| 0| 0| 0| 0| 1| 1| 1| 1| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|             
                                           | 7| 4| 2| 1| 3| 5| 4| 2| 7| 8| 9| 2| 3| 7| 8| 1| 2| 5| 5| 8| 9| 2| 2| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                         +        +                                       |             
      Adenoma                              |                                  X                                       |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |     A      |
    1250 PPM                               | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1|                                            |     L      |
                                           | 9| 4| 5| 6| 4| 8| 6| 0| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Carcinoma                            |                                                                          |         12 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  40        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          3 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          9 |
      Hepatocellular Carcinoma, Multiple   | X              X           X                                             |          7 |
      Hepatocellular Adenoma               | X                 X                                                      |         12 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          6 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                          +                                             |  12        |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
          Large, Cecum                     |                                                                          |          1 |
      Hemangiosarcoma                      |                            X                                             |          8 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |     A      |
    1250 PPM                               | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1|                                            |     L      |
                                           | 9| 4| 5| 6| 4| 8| 6| 0| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Pharyngeal, Squamous Cell Carcinoma  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +        +              +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  M  M  +  +  +  +  +                                             |  50        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  I  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |     A      |
    1250 PPM                               | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1|                                            |     L      |
                                           | 9| 4| 5| 6| 4| 8| 6| 0| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Interstitial Cell, Adenoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Pancreatic, Histiocytic Sarcoma      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M                                             |  55        |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
          Large, Cecum                     |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |     A      |
    1250 PPM                               | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1|                                            |     L      |
                                           | 9| 4| 5| 6| 4| 8| 6| 0| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |                                                                          |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | I  +  +  M  +  +  +  +  +  +                                             |  52        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteoma                     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   6        |
      Hemangiosarcoma                      |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |          X                                                               |          6 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 1| 1| 1| 0| 0| 0| 1| 1| 1|                                            |     A      |
    1250 PPM                               | 9| 0| 1| 1| 7| 8| 9| 0| 0| 1|                                            |     L      |
                                           | 9| 4| 5| 6| 4| 8| 6| 0| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
          Large, Cecum                     |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          2 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|             
                                           | 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|             
                                           | 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | A  +  A  A  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  A  A  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  A  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  +  +  +  A|             
      Muscularis, Serosa, Hemangiosarcoma  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  A  +  +  +  +  A  A  +  +  A  +  +  A  +  +  A  A  A  +  A|             
      Carcinoma                            | X                                      X        X                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  +  A  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  A  A  A  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  A  A  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  A  A  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  A  A  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |       X                                                                  |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |                                     X                                    |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +  +  +  +  +        +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                        X                                 |             
      Hemangiosarcoma                      |          X     X     X        X           X  X  X  X     X  X  X  X  X   |             
      Hemangiosarcoma, Multiple            |             X                    X                                      X|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|             
                                           | 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|             
                                           | 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Hemangiosarcoma              |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  A  +  A|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  I  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  I  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  M  +  M|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
      Pelvic, Hemangiosarcoma              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |          +                                         +                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|             
                                           | 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|             
                                           | 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +        +                                                     +|             
      Mediastinal, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Mesentery            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  A  +  +  +  M|             
      Hemangioma                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                        X        X                        |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  I  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|             
                                           | 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|             
                                           | 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                          X               |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +     +     +     +     +     +                 +           +  +   |             
      Hemangiosarcoma                      |       X     X           X     X     X                 X           X      |             
      Hemangiosarcoma, Multiple            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                        +              +                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                        +              +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X              X                          X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                   X      |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |       X                                                                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 7| 0| 6| 1| 1| 2| 3| 5| 5| 6| 6| 6| 7| 7| 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2|             
                                           | 0| 3| 5| 0| 9| 3| 4| 1| 1| 6| 7| 9| 0| 6| 5| 2| 2| 6| 7| 4| 6| 7| 0| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 7| 7| 5| 4| 7| 6| 6| 4| 4| 8| 4| 5| 4| 3| 6| 3| 7| 6| 3| 2| 5| 6| 3|             
                                           | 7| 4| 7| 1| 1| 9| 5| 0| 9| 1| 0| 0| 4| 4| 8| 8| 3| 6| 6| 4| 4| 7| 3| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                          +               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                   X                                                      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|             
                                           | 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  A  +  A  A  +  A  M  +  A  +  +  M  A  A  A  A  +  M  +  A  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Muscularis, Serosa, Hemangiosarcoma  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  A  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  A  A  A  A  +  +  M  +  +  +  +  +  +  A  A  +  +  A  +  +  +  A  A|             
      Carcinoma                            |                               X  X  X                 X                  |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  A  A  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  A  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  A  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  +  +  A  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                                          |             
      Hepatocellular Carcinoma             |                                  X                             X         |             
      Hepatocellular Carcinoma, Multiple   |                                     X                                    |             
      Hepatocellular Adenoma               |                                                                          |             
      Hepatocellular Adenoma, Multiple     |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +  +  +  +     +        +  +     +        +     +  +  +     +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                                                                          |             
      Hemangiosarcoma                      |          X  X  X        X        X  X     X        X     X  X  X     X  X|             
      Hemangiosarcoma, Multiple            | X                                                                        |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|             
                                           | 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Hemangiosarcoma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Pelvic, Hemangiosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|             
                                           | 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemangiosarcoma                      |                                     X                       X            |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +                       +        +                     |             
      Mediastinal, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Mesentery            |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Intestine     |                                                                          |             
          Large, Cecum                     |                               X                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  +  M  +  +  I  +  +  +  +  I  +  +  +  +  M  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|             
                                           | 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Hemangiosarcoma |                   X  X                                            X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |    +  +  +     +        +        +  +  +     +  +     +  +  +     +  +  +|             
      Hemangiosarcoma                      |       X  X     X                    X  X        X     X     X     X  X  X|             
      Hemangiosarcoma, Multiple            |    X                    X                    X           X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                   X        X                                             |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                           X        X                     |             
      Hemangiosarcoma, Metastatic, Skin    |                   X  X                                                   |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |                                                          X               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
                                           | 6| 1| 3| 4| 9| 0| 4| 8| 8| 3| 4| 6| 6| 7| 0| 0| 3| 4| 6| 6| 7| 9| 9| 9| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 2| 2| 4| 4| 5| 5| 5| 7| 6| 3| 2| 2| 3| 3| 5| 6| 2| 3| 4| 7| 3| 6| 6| 2|             
                                           | 5| 2| 6| 5| 3| 9| 8| 6| 0| 8| 1| 5| 8| 5| 7| 0| 5| 9| 0| 7| 8| 3| 2| 7| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         |                                              +                           |             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  A  +  +  +  A                                             |  31        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  A  +  +  +  A                                             |  46        |
      Muscularis, Serosa, Hemangiosarcoma  |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  A  +  +  +  A                                             |  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  A  +  +  +  +                                             |  36        |
      Carcinoma                            |                      X     X                                             |          9 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  +  +  A                                             |  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  A                                             |  35        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  +  +  A                                             |  35        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hemangiosarcoma                      |    X                                                                     |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |                                                                          |          1 |
      Hepatocellular Carcinoma             |                      X     X                                             |          4 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Hepatocellular Adenoma, Multiple     |                      X                                                   |          2 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +     +  +  +  +  +                                             |  42        |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
          Large, Cecum                     |                                                                          |          1 |
      Hemangiosarcoma                      | X                 X     X  X                                             |         30 |
      Hemangiosarcoma, Multiple            |    X  X  X     X                                                         |          8 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acinus, Hemangiosarcoma              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  I  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +                                             |  57        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  M  I  M                                             |  50        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   2        |
      Pelvic, Hemangiosarcoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   2        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  I  +  +  +  +  M                                             |  57        |
      Hemangiosarcoma                      |                X                                                         |          4 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Mediastinal, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Mesentery            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |  50        |
      Hemangioma                           |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Carcinoma, Metastatic, Intestine     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Large, Cecum                     |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | I  +  +  M  +  +  +  M  +  +                                             |  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |    X  X        X     X  X                                                |          8 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Hemangiosarcoma                      | X  X  X  X     X     X  X                                                |         25 |
      Hemangiosarcoma, Multiple            |             X     X        X                                             |          8 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          4 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                         X                                                |          3 |
      Hemangiosarcoma, Metastatic, Skin    |                      X                                                   |          3 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                                                                          |          1 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                      X                                                   |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         |       +                 +                                                |   3        |
      Adenoma                              |                         X                                                |          1 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 6| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 7| 8| 8| 9| 9| 9| 1| 2| 4| 0|                                            |            |
                                           | 2| 8| 8| 0| 2| 6| 9| 4| 5| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    2500 PPM                               | 7| 4| 5| 3| 7| 2| 7| 7| 6| 4|                                            |     L      |
                                           | 3| 6| 2| 9| 2| 1| 9| 4| 6| 2|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|             
    5000 PPM                               | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|             
                                           | 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  M  A  A  M  +  +  +  +  M  +  +  A  +  +  +  A  A  M|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  A  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  A  A  A  +  +  +  +  +  A  +  +  A  +  +  +  A  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  A  A  A  +  +  +  +  +  A  +  +  A  +  +  +  A  A  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  M  A  A  A  +  +  +  +  +  A  +  +  A  +  +  +  A  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                         X                                                |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +              +        +        +  +        +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |       X              X        X                    X  X           X     X|             
      Hemangiosarcoma, Multiple            |                                        X  X              X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|             
    5000 PPM                               | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|             
                                           | 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  +  I  +  M  +  +  M  +  +  I  +  +  +  I  +  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                   +                    +                                 |             
      Hemangiosarcoma                      |                   X                                                      |             
      Pelvic, Hemangiosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|             
    5000 PPM                               | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|             
                                           | 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Inguinal, Hemangiosarcoma,           |                                                                          |             
          Metastatic, Skeletal Muscle      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  M  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |                X                       X  X        X                     |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |                               X                       X     X           X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +           +  +  +  +  +  +     +  +        +  +  +  +  +   |             
      Hemangiosarcoma                      | X  X  X  X  X           X  X     X     X     X                           |             
      Hemangiosarcoma, Multiple            |                               X     X           X        X  X  X     X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                             DAY ON TEST   | 7| 9| 9| 0| 1| 2| 3| 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8|             
                                           | 7| 5| 7| 2| 2| 6| 9| 5| 0| 4| 8| 5| 8| 8| 8| 8| 1| 2| 4| 5| 5| 5| 6| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| 2| 1| 2| 1|             
    5000 PPM                               | 9| 0| 0| 1| 3| 1| 2| 3| 2| 3| 2| 9| 9| 0| 1| 3| 8| 1| 0| 8| 9| 2| 8| 2| 8|             
                                           | 0| 1| 7| 3| 5| 7| 7| 3| 3| 1| 4| 3| 9| 5| 8| 2| 3| 1| 3| 8| 4| 2| 6| 0| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +                                      +                 +  +  +         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +                                      +                 +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                   X      |             
      Hemangiosarcoma, Metastatic, Skin    |                X                                   X                    X|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |                                                                          |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |             X           X  X                                             |             
      Mediastinum, Hemangiosarcoma         |                               X                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hemangiosarcoma             |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|             
    5000 PPM                               | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|             
                                           | 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  I  A  A  A  M  +  +  A  +  +  A  +  A  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  A  +  A  +  +  A  +  +  A  +  A  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  A  A  +  A  +  +  +  +  +  A  +  A  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  +  +  A  +  A  +  +  A  +  +  A  +  A  +  +  +  A  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  +  A  +  +  A  +  +  A  +  +  A  +  A  +  +  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +     +  +     +     +     +  +  +     +     +  +     +  +  +  +     +  +|             
      Hemangiosarcoma                      |          X     X     X        X  X     X     X  X     X     X  X         |             
      Hemangiosarcoma, Multiple            | X     X                    X                             X           X  X|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|             
    5000 PPM                               | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|             
                                           | 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  I  +  +  M  +  +  +  +  M  +  I  +  +  +  +  +  +  M  I  +|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Hemangiosarcoma                      |                                                                          |             
      Pelvic, Hemangiosarcoma              |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                X                                                         |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|             
    5000 PPM                               | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|             
                                           | 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +                                             |             
      Inguinal, Hemangiosarcoma,           |                                                                          |             
          Metastatic, Skeletal Muscle      |                            X                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemangiosarcoma |          X     X     X                    X  X        X                  |             
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |             
           Multiple                        |    X  X                 X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +  +     +  +     +  +  +  +  +  +  +     +     +  +     +  +  +  +  +  +|             
      Hemangiosarcoma                      |    X     X        X  X  X        X        X                              |             
      Hemangiosarcoma, Multiple            |             X              X  X     X           X  X     X  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
                                           | 1| 1| 1| 2| 2| 2| 3| 4| 4| 6| 1| 3| 3| 5| 6| 6| 8| 8| 8| 9| 9| 9| 2| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 1| 1| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| 1| 1|             
    5000 PPM                               | 0| 2| 3| 9| 9| 1| 0| 8| 0| 8| 1| 8| 1| 3| 0| 2| 8| 2| 2| 9| 1| 3| 3| 8| 9|             
                                           | 2| 1| 7| 6| 8| 4| 4| 1| 0| 2| 5| 4| 2| 0| 8| 6| 9| 5| 9| 7| 9| 4| 9| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +                          +     +        +           +         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |          +                          +     +        +           +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Mesentery                        |                                                                          |             
      Hemangiosarcoma, Metastatic, Skin    |                                              X                           |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Uncertain Primary Site           |          X                                                               |             
      Hemangiosarcoma, Metastatic,         |                                                                          |             
          Skeletal Muscle                  |             X                       X                       X  X         |             
      Mediastinum, Hemangiosarcoma         |                   X     X                                                |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hemangiosarcoma             |                                                                          |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6|                                            |            |
                                           | 4| 4| 0| 2| 2| 7| 0| 9| 0| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |     A      |
    5000 PPM                               | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3|                                            |     L      |
                                           | 6| 8| 1| 9| 0| 6| 6| 2| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  A  +  A  M                                             |  35        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  A  A                                             |  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +                                             |  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A                                             |  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  A  A                                             |  39        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hepatocellular Carcinoma             |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +     +  +     +  +                                             |  38        |
      Hemangiosarcoma                      |       X  X     X  X     X  X                                             |         24 |
      Hemangiosarcoma, Multiple            | X  X                                                                     |         14 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemangiosarcoma                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Squamous Cell Papilloma              |             X                                                            |          2 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6|                                            |            |
                                           | 4| 4| 0| 2| 2| 7| 0| 9| 0| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |     A      |
    5000 PPM                               | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3|                                            |     L      |
                                           | 6| 8| 1| 9| 0| 6| 6| 2| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma                      |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  M  +                                             |  46        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Pelvic, Hemangiosarcoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6|                                            |            |
                                           | 4| 4| 0| 2| 2| 7| 0| 9| 0| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |     A      |
    5000 PPM                               | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3|                                            |     L      |
                                           | 6| 8| 1| 9| 0| 6| 6| 2| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
      Inguinal, Hemangiosarcoma,           |                                                                          |            |
          Metastatic, Skeletal Muscle      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M                                             |  54        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M                                             |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  I                                             |  54        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Hemangiosarcoma |                   X        X                                             |         12 |
      Subcutaneous Tissue, Hemangiosarcoma,|                                                                          |            |
           Multiple                        |             X                                                            |          8 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6|                                            |            |
                                           | 4| 4| 0| 2| 2| 7| 0| 9| 0| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |     A      |
    5000 PPM                               | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3|                                            |     L      |
                                           | 6| 8| 1| 9| 0| 6| 6| 2| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +                                                |  47        |
      Hemangiosarcoma                      |             X        X                                                   |         19 |
      Hemangiosarcoma, Multiple            | X  X  X  X     X  X     X                                                |         26 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +     +                                                                  |  12        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +     +                                                                  |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Mesentery                        |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Skin    |                                                                          |          4 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Uncertain Primary Site           |                         X                                                |          2 |
      Hemangiosarcoma, Metastatic,         |                                                                          |            |
          Skeletal Muscle                  |          X                                                               |          8 |
      Mediastinum, Hemangiosarcoma         |                      X                                                   |          4 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 05203-09          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: CHRONIC                                           O-NITROTOLUENE                                      Date: 11/16/00    
Route: DOSED FEED                                                                                                 Time: 10:17:16    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 1| 2| 2| 2| 2| 4| 4| 5| 6|                                            |            |
                                           | 4| 4| 0| 2| 2| 7| 0| 9| 0| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |     A      |
    5000 PPM                               | 1| 2| 9| 0| 4| 3| 0| 9| 1| 3|                                            |     L      |
                                           | 6| 8| 1| 9| 0| 6| 6| 2| 0| 8|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hemangiosarcoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |       +                                                                  |   2        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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