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TDMS Study 05205-07 Pathology Tables

NTP Experiment-Test: 05205-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/04/01
Route: DOSED FEED                                                                                                 Time: 07:51:49

                                                          Final#2/Rats




       Facility:  Southern Research Institute

       Chemical CAS #:  99-99-0

       Lock Date:  08/24/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05205-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/04/01    
Route: DOSED FEED                                                                                                 Time: 07:51:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            1            1            2                                     
    Moribund Sacrifice                                 7           12           10            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           37           39           41                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)                                   
      Edema                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (47)         (50)         (48)                                   
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    1 (2%)       2 (4%)                                
      Basophilic Focus                                44 (88%)     41 (82%)     49 (98%)     46 (92%)                               
      Clear Cell Focus                                12 (24%)     11 (22%)     18 (36%)     10 (20%)                               
      Cyst                                                                                    1 (2%)                                
      Eosinophilic Focus                               1 (2%)       2 (4%)       7 (14%)      9 (18%)                               
      Fatty Change                                     1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       3 (6%)       7 (14%)     14 (28%)     12 (24%)                               
      Infiltration Cellular, Mixed Cell               41 (82%)     33 (66%)     43 (86%)     49 (98%)                               
      Mixed Cell Focus                                 4 (8%)       3 (6%)       5 (10%)      3 (6%)                                
      Necrosis, Focal                                  1 (2%)                    1 (2%)       1 (2%)                                
      Regeneration                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                           3 (6%)       1 (2%)                                                          
      Centrilobular, Necrosis                          2 (4%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            2 (4%)       1 (2%)                                                          
      Kupffer Cell, Pigmentation                       2 (4%)       3 (6%)                                                          
   Mesentery                                          (5)          (1)          (3)                                                 
      Fat, Necrosis                                    5 (100%)     1 (100%)     3 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                          3 (6%)       1 (2%)       8 (16%)      4 (8%)                                
      Acinus, Hyperplasia, Focal                                                 1 (2%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)                                 2 (4%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05205-07         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/04/01    
Route: DOSED FEED                                                                                                 Time: 07:51:49    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                          1 (2%)                                                                       
      Ulcer                                            2 (4%)                                                                       
      Epithelium, Hyperplasia                          3 (6%)       2 (4%)       1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                                       2 (4%)                                                          
   Tooth                                                           (1)                                                              
      Malformation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  13 (26%)     10 (20%)     11 (22%)      8 (16%)                               
      Inflammation, Chronic                                                      3 (6%)                                             
      Endocardium, Fibrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule               10 (20%)      6 (12%)      9 (18%)      5 (10%)                               
      Degeneration, Fatty                             11 (22%)     19 (38%)      9 (18%)     10 (20%)                               
      Hyperplasia, Focal                               5 (10%)      8 (16%)      3 (6%)       3 (6%)                                
      Hypertrophy                                                                2 (4%)                                             
      Hypertrophy, Focal                               4 (8%)      14 (28%)      7 (14%)      2 (4%)                                
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)