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TDMS Study 05205-07 Pathology Tables

NTP Experiment-Test: 05205-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/15/01
Route: DOSED FEED                                                                                                 Time: 10:40:52

                                                          FINAL#2/RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  99-99-0

       Lock Date:  08/24/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05205-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/15/01  
Route: DOSED FEED                                                                                                 Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            1            1            2                                     
    Moribund Sacrifice                                 7           12           10            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           37           39           41                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (49)         (50)                                   
   Intestine Large, Cecum                             (50)         (49)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Oral Mucosa                                        (1)                       (1)          (1)                                    
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Acinus, Adenoma                                               1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (3)          (1)                       (1)                                    
      Squamous Cell Carcinoma                          1 (33%)      1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Endocardium, Schwannoma Malignant                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                                    1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       1 (2%)                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05205-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/15/01  
Route: DOSED FEED                                                                                                 Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          15 (30%)     23 (46%)     17 (34%)     11 (22%)                               
      Pars Intermedia, Adenoma                                                   1 (2%)       1 (2%)                                
      Pars Intermedia, Carcinoma                                                              1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  6 (12%)      2 (4%)       9 (18%)      2 (4%)                                
      C-Cell, Carcinoma                                                          1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                          7 (14%)      8 (16%)     13 (26%)      6 (12%)                               
      Adenoma, Multiple                                                          2 (4%)                                             
      Carcinoma                                        2 (4%)       4 (8%)       6 (12%)      1 (2%)                                
      Carcinoma, Multiple                                                                     1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
      Fibroma                                                       1 (2%)                                                          
      Hemangioma                                       1 (2%)                                                                       
      Leiomyoma                                                                               1 (2%)                                
      Polyp Stromal                                    6 (12%)      4 (8%)      10 (20%)      8 (16%)                               
      Polyp Stromal, Multiple                                                    1 (2%)                                             
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node                                         (4)          (8)          (3)          (11)                                   
   Lymph Node, Mandibular                             (50)         (50)         (48)         (50)                                   
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05205-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 01/15/01  
Route: DOSED FEED                                                                                                 Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (48)         (48)         (45)         (50)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Fibroadenoma                                    14 (28%)     15 (30%)     17 (34%)      5 (10%)                               
      Fibroadenoma, Multiple                                        2 (4%)       3 (6%)                                             
   Skin                                               (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Trichoepithelioma                                                                       1 (2%)                                
      Subcutaneous Tissue, Fibroma                                                            1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma NOS                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                            1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
      Glioma Malignant                                                                        1 (2%)                                
      Oligodendroglioma Malignant                                                1 (2%)                                             
   Spinal Cord                                        (1)          (2)                                                              
_________________________________________________________________________