Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/12610

TDMS Study 05205-07 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 01/04/01       
EXPERIMENT: 05205 TEST: 07                                                                                     TIME: 08:00:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 99-99-0         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            Final#2/Rats                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 01/04/01       
EXPERIMENT: 05205 TEST: 07                                                                                     TIME: 08:00:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 99-99-0         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                  P-NITROTOLUENE                                                                                  
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Eye: Retina                            Degeneration                                                                                 
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Hyaline Droplet                                                                              
                                       Hyperplasia Oncocytic                                                                        
                                       Pigmentation                                                                                 
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Lung                                   Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
Lymph Node, Mandibular                 Pigmentation                                                                                 
Lymph Node, Mesenteric                 Pigmentation                                                                                 
Mammary Gland                          Hyperplasia                                                                                  
Mesentery: Fat                         Necrosis                                                                                     
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Pancreas                               Atrophy                                                                                      
Preputial Gland                        Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Prostate: Epithelium                   Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Stomach, Glandular                     Erosion                                                                                      
Testes: Germinal Epithelium            Atrophy                                                                                      
Testes: Interstitial Cell              Hyperplasia                                                                                  
Thyroid Gland                          Ultimobranchial Cyst                                                                         
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Degeneration Fatty                                                                           
                                       Hypertrophy Focal                                                                            
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Infiltration Cellular Histiocyte                                                             
Bone: Femur                            Osteopetrosis                                                                                
Kidney                                 Mineralization                                                                               
Kidney: Renal Tubule                   Hyaline Droplet                                                                              
                                       Hyperplasia Oncocytic                                                                        
                                       Pigmentation                                                                                 
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Infiltration Cellular Mixed Cell                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 01/04/01       
EXPERIMENT: 05205 TEST: 07                                                                                     TIME: 08:00:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 99-99-0         
Lung                                   Infiltration Cellular Histiocyte                                                             
Lymph Node: Pancreatic                 Pigmentation                                                                                 
Mammary Gland                          Hyperplasia                                                                                  
Nose                                   Inflammation Chronic                                                                         
Pituitary Gland: Pars Distalis         Cyst                                                                                         
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Uterus                                 Prolapse                                                                                     
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                   P-NITROTOLUENE 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   4/50 (8%)    11/50 (22%)  13/50 (26%) |10/50 (20%)  6/50 (12%)   9/50 (18%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     8/45.64      4/45.60      11/47.96     13/46.71    |10/46.11     6/46.63      9/47.21      5/48.20      | 
|POLY-3 PERCENT (g) |     17.5%        8.8%         22.9%        27.8%       |21.7%        12.9%        19.1%        10.4%        | 
|TERMINAL (d)       |     6/31 (19%)   3/38 (8%)    7/38 (18%)   12/40 (30%) |9/39 (23%)   4/37 (11%)   8/39 (21%)   4/41 (10%)   | 
|FIRST INCIDENCE    |     592          516          659          682         |676          639          675          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101      P=0.120N     P=0.467      P=0.343     |P=0.129N     P=0.238N     P=0.497N     P=0.113N     | 
|POLY 3             |     P=0.044 *    P=0.177N     P=0.348      P=0.175     |P=0.134N     P=0.198N     P=0.477N     P=0.110N     | 
|POLY 1.5           |     P=0.042 *    P=0.177N     P=0.331      P=0.170     |P=0.143N     P=0.201N     P=0.485N     P=0.117N     | 
|POLY 6             |     P=0.048 *    P=0.175N     P=0.370      P=0.183     |P=0.127N     P=0.197N     P=0.475N     P=0.104N     | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.178N     P=0.320      P=0.189     |P=0.130N     P=0.201N     P=0.478N     P=0.106N     | 
|COCH-ARM / FISHERS |     P=0.041 *    P=0.178N     P=0.306      P=0.163     |P=0.158N     P=0.207N     P=0.500N     P=0.131N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  9/50 (18%)   9/50 (18%)   8/50 (16%)  |11/50 (22%)  19/50 (38%)  9/50 (18%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     13/46.51     9/45.21      9/48.16      8/46.76     |11/45.99     19/46.33     9/47.85      10/48.20     | 
|POLY-3 PERCENT (g) |     28.0%        19.9%        18.7%        17.1%       |23.9%        41.0%        18.8%        20.8%        | 
|TERMINAL (d)       |     4/31 (13%)   8/38 (21%)   6/38 (16%)   6/40 (15%)  |10/39 (26%)  16/37 (43%)  8/39 (21%)   8/41 (20%)   | 
|FIRST INCIDENCE    |     591          659          621          693         |708          724          387          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.091N     P=0.169N     P=0.158N     P=0.098N    |P=0.148N     P=0.048 *    P=0.402N     P=0.448N     | 
|POLY 3             |     P=0.145N     P=0.255N     P=0.205N     P=0.157N    |P=0.149N     P=0.060      P=0.363N     P=0.452N     | 
|POLY 1.5           |     P=0.151N     P=0.245N     P=0.216N     P=0.158N    |P=0.164N     P=0.061      P=0.375N     P=0.469N     | 
|POLY 6             |     P=0.140N     P=0.270N     P=0.196N     P=0.156N    |P=0.136N     P=0.057      P=0.359N     P=0.435N     | 
|LOGISTIC REGRESSION|     P=0.149N     P=0.233N     P=0.264N     P=0.158N    |P=0.152N     P=0.054      P=0.392N     P=0.428N     | 
|COCH-ARM / FISHERS |     P=0.160N     P=0.235N     P=0.235N     P=0.163N    |P=0.194N     P=0.063      P=0.402N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |5/50 (10%)   8/50 (16%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.85      3/44.95      1/47.38      0/46.53     |5/45.91      8/46.31      3/47.00      3/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         6.7%         2.1%         0.0%        |10.9%        17.3%        6.4%         6.2%         | 
|TERMINAL (d)       |     0/31 (0%)    3/38 (8%)    1/38 (3%)    0/40 (0%)   |5/39 (13%)   7/37 (19%)   3/39 (8%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |729 (T)      724          729 (T)      728          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.159      P=0.541      (e)         |P=0.130N     P=0.246      P=0.355N     P=0.329N     | 
|POLY 3             |     P=0.350N     P=0.119      P=0.511      (e)         |P=0.135N     P=0.281      P=0.344N     P=0.332N     | 
|POLY 1.5           |     P=0.356N     P=0.119      P=0.507      (e)         |P=0.141N     P=0.280      P=0.348N     P=0.341N     | 
|POLY 6             |     P=0.340N     P=0.120      P=0.516      (e)         |P=0.129N     P=0.280      P=0.342N     P=0.324N     | 
|LOGISTIC REGRESSION|     (e)          P=0.159      P=0.541      (e)         |P=0.120N     P=0.272      P=0.355N     P=0.306N     | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.121      P=0.500      (e)         |P=0.154N     P=0.277      P=0.357N     P=0.357N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.85      0/44.95      0/47.38      0/46.53     |0/45.91      0/46.28      2/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    2/39 (5%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.279N     P=0.459N     P=0.459N     P=0.449N    |P=0.608      (e)          P=0.238      (e)          | 
|POLY 3             |     P=0.307N     P=0.500N     P=0.489N     P=0.493N    |P=0.619      (e)          P=0.243      (e)          | 
|POLY 1.5           |     P=0.306N     P=0.500N     P=0.493N     P=0.496N    |P=0.610      (e)          P=0.241      (e)          | 
|POLY 6             |     P=0.309N     P=0.498N     P=0.484N     P=0.488N    |P=0.627      (e)          P=0.243      (e)          | 
|LOGISTIC REGRESSION|     P=0.279N     (e)          (e)          (e)         |(e)          (e)          P=0.238      (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.595      (e)          P=0.247      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |4/50 (8%)    14/50 (28%)  7/50 (14%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.02      2/44.95      3/47.96      2/46.53     |4/45.91      14/46.92     7/47.00      2/48.05      | 
|POLY-3 PERCENT (g) |     4.4%         4.5%         6.3%         4.3%        |8.7%         29.8%        14.9%        4.2%         | 
|TERMINAL (d)       |     1/31 (3%)    2/38 (5%)    1/38 (3%)    2/40 (5%)   |4/39 (10%)   11/37 (30%)  7/39 (18%)   2/41 (5%)    | 
|FIRST INCIDENCE    |     687          729 (T)      621          729 (T)     |729 (T)      577          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.541N     P=0.638N     P=0.557      P=0.617N    |P=0.060N     P=0.008 **   P=0.259      P=0.314N     | 
|POLY 3             |     P=0.589      P=0.693      P=0.529      P=0.682N    |P=0.053N     P=0.009 **   P=0.275      P=0.317N     | 
|POLY 1.5           |     P=0.580      P=0.694      P=0.517      P=0.687N    |P=0.059N     P=0.008 **   P=0.271      P=0.324N     | 
|POLY 6             |     P=0.584N     P=0.694N     P=0.544      P=0.675N    |P=0.048N*    P=0.009 **   P=0.275      P=0.310N     | 
|LOGISTIC REGRESSION|     P=0.573      P=0.692N     P=0.456      P=0.676N    |P=0.059N     P=0.010 *    P=0.259      P=0.314N     | 
|COCH-ARM / FISHERS |     P=0.569      P=0.691N     P=0.500      P=0.691N    |P=0.076N     P=0.009 **   P=0.262      P=0.339N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    3/50 (6%)    3/50 (6%)   |3/49 (6%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.32      3/43.95      3/47.38      3/46.62     |3/44.91      2/46.61      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     4.4%         6.8%         6.3%         6.4%        |6.7%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    3/37 (8%)    3/38 (8%)    2/40 (5%)   |3/38 (8%)    1/37 (3%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     592          729 (T)      729 (T)      707         |729 (T)      639          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533      P=0.562      P=0.577      P=0.580     |P=0.035N*    P=0.508N     P=0.116N     P=0.108N     | 
|POLY 3             |     P=0.461      P=0.486      P=0.520      P=0.513     |P=0.036N*    P=0.483N     P=0.111N     P=0.107N     | 
|POLY 1.5           |     P=0.453      P=0.488      P=0.512      P=0.507     |P=0.036N*    P=0.486N     P=0.112N     P=0.110N     | 
|POLY 6             |     P=0.474      P=0.485      P=0.530      P=0.522     |P=0.035N*    P=0.481N     P=0.110N     P=0.104N     | 
|LOGISTIC REGRESSION|     P=0.462      P=0.491      P=0.489      P=0.493     |P=0.037N*    P=0.488N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.441      P=0.490      P=0.500      P=0.500     |P=0.038N*    P=0.490N     P=0.117N     P=0.117N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/50 (14%)   3/50 (6%)    3/50 (6%)   |4/50 (8%)    3/50 (6%)    6/50 (12%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     4/46.37      7/46.50      3/47.60      3/47.89     |4/47.10      3/46.31      6/48.95      7/48.99      | 
|POLY-3 PERCENT (g) |     8.6%         15.1%        6.3%         6.3%        |8.5%         6.5%         12.3%        14.3%        | 
|TERMINAL (d)       |     0/31 (0%)    3/38 (8%)    1/38 (3%)    0/40 (0%)   |2/39 (5%)    2/37 (5%)    0/39 (0%)    3/41 (7%)    | 
|FIRST INCIDENCE    |     504          592          679          496         |497          724          387          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223N     P=0.297      P=0.441N     P=0.482N    |P=0.172      P=0.513N     P=0.391      P=0.302      | 
|POLY 3             |     P=0.242N     P=0.263      P=0.486N     P=0.482N    |P=0.154      P=0.509N     P=0.394      P=0.285      | 
|POLY 1.5           |     P=0.249N     P=0.262      P=0.491N     P=0.490N    |P=0.146      P=0.505N     P=0.386      P=0.276      | 
|POLY 6             |     P=0.232N     P=0.267      P=0.479N     P=0.472N    |P=0.164      P=0.516N     P=0.402      P=0.295      | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.248      P=0.658N     P=0.623N    |P=0.055      P=0.516N     P=0.217      P=0.143      | 
|COCH-ARM / FISHERS |     P=0.260N     P=0.262      P=0.500N     P=0.500N    |P=0.132      P=0.500N     P=0.370      P=0.262      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      0/46.53     |0/45.91      1/46.28      1/47.00      5/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.1%         10.4%        | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    1/37 (3%)    1/39 (3%)    5/41 (12%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.007 **   P=0.489      P=0.500      P=0.038 *    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.006 **   P=0.502      P=0.505      P=0.035 *    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.006 **   P=0.501      P=0.503      P=0.033 *    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.006 **   P=0.501      P=0.505      P=0.036 *    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.489      P=0.500      P=0.038 *    | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.006 **   P=0.500      P=0.500      P=0.028 *    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Cranium                                                                                                                    | 
|     Osteopetrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |12/49 (24%)  12/50 (24%)  11/50 (22%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |     1/44.95      0/44.95      0/47.38      0/46.53     |12/44.91     12/46.79     11/47.48     11/48.77     | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |26.7%        25.7%        23.2%        22.6%        | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |12/38 (32%)  11/37 (30%)  9/39 (23%)   9/41 (22%)   | 
|FIRST INCIDENCE    |     704          ---          ---          ---         |729 (T)      577          655          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.489N     P=0.475N     P=0.480N    |P=0.337N     P=0.568      P=0.470N     P=0.418N     | 
|POLY 3             |     P=0.307N     P=0.500N     P=0.489N     P=0.493N    |P=0.349N     P=0.548N     P=0.439N     P=0.410N     | 
|POLY 1.5           |     P=0.306N     P=0.500N     P=0.494N     P=0.496N    |P=0.374N     P=0.556N     P=0.453N     P=0.436N     | 
|POLY 6             |     P=0.308N     P=0.499N     P=0.485N     P=0.489N    |P=0.322N     P=0.542N     P=0.426N     P=0.383N     | 
|LOGISTIC REGRESSION|     P=0.305N     P=0.500N     P=0.502N     P=0.499N    |P=0.362N     P=0.562N     P=0.449N     P=0.423N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.414N     P=0.570N     P=0.478N     P=0.478N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Femur                                                                                                                      | 
|     Osteopetrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |19/49 (39%)  14/50 (28%)  10/50 (20%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/44.85      1/44.95      0/47.38      0/46.53     |19/47.24     14/46.66     10/47.03     6/48.44      | 
|POLY-3 PERCENT (g) |     4.5%         2.2%         0.0%         0.0%        |40.2%        30.0%        21.3%        12.4%        | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    0/38 (0%)    0/40 (0%)   |13/38 (34%)  12/37 (32%)  9/39 (23%)   5/41 (12%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |380          659          721          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078N     P=0.429N     P=0.195N     P=0.184N    |P<0.001N**   P=0.231N     P=0.041N*    P=0.003N**   | 
|POLY 3             |     P=0.098N     P=0.499N     P=0.225N     P=0.229N    |P<0.001N**   P=0.206N     P=0.036N*    P<0.001N**   | 
|POLY 1.5           |     P=0.099N     P=0.500N     P=0.230N     P=0.233N    |P<0.001N**   P=0.194N     P=0.034N*    P<0.001N**   | 
|POLY 6             |     P=0.097N     P=0.497N     P=0.219N     P=0.224N    |P<0.001N**   P=0.223N     P=0.041N*    P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.078N     P=0.429N     (e)          (e)         |P<0.001N**   P=0.179N     P=0.035N*    P=0.004N**   | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P<0.001N**   P=0.178N     P=0.033N*    P=0.002N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    7/50 (14%)   4/50 (8%)   |4/50 (8%)    6/50 (12%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     5/45.44      3/46.18      7/48.01      4/46.53     |4/46.58      6/46.72      3/47.20      3/48.69      | 
|POLY-3 PERCENT (g) |     11.0%        6.5%         14.6%        8.6%        |8.6%         12.8%        6.4%         6.2%         | 
|TERMINAL (d)       |     2/31 (7%)    0/38 (0%)    5/38 (13%)   4/40 (10%)  |3/39 (8%)    4/37 (11%)   2/39 (5%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     639          515          627          729 (T)     |504          639          676          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.339N     P=0.495      P=0.382N    |P=0.269N     P=0.354      P=0.497N     P=0.468N     | 
|POLY 3             |     P=0.533N     P=0.347N     P=0.419      P=0.485N    |P=0.276N     P=0.372      P=0.493N     P=0.476N     | 
|POLY 1.5           |     P=0.539N     P=0.351N     P=0.403      P=0.491N    |P=0.284N     P=0.371      P=0.495N     P=0.484N     | 
|POLY 6             |     P=0.526N     P=0.341N     P=0.437      P=0.477N    |P=0.268N     P=0.372      P=0.493N     P=0.468N     | 
|LOGISTIC REGRESSION|     P=0.550      P=0.362N     P=0.361      P=0.483N    |P=0.344N     P=0.364      P=0.521N     P=0.629N     | 
|COCH-ARM / FISHERS |     P=0.549N     P=0.357N     P=0.380      P=0.500N    |P=0.299N     P=0.370      P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hydrocephalus                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    4/50 (8%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.85      2/45.83      2/47.75      2/46.53     |1/45.91      4/46.72      1/47.20      1/48.20      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         4.2%         4.3%        |2.2%         8.6%         2.1%         2.1%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    2/40 (5%)   |1/39 (3%)    2/37 (5%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          515          659          729 (T)     |729 (T)      639          676          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281      P=0.239      P=0.269      P=0.296     |P=0.352N     P=0.177      P=0.758N     P=0.750N     | 
|POLY 3             |     P=0.258      P=0.242      P=0.251      P=0.245     |P=0.352N     P=0.184      P=0.754N     P=0.750N     | 
|POLY 1.5           |     P=0.251      P=0.240      P=0.246      P=0.242     |P=0.359N     P=0.182      P=0.756N     P=0.753N     | 
|POLY 6             |     P=0.268      P=0.246      P=0.259      P=0.251     |P=0.345N     P=0.186      P=0.753N     P=0.746N     | 
|LOGISTIC REGRESSION|     P=0.200      P=0.195      P=0.201      P=0.296     |P=0.390N     P=0.180      P=0.761      P=0.764      | 
|COCH-ARM / FISHERS |     P=0.242      P=0.247      P=0.247      P=0.247     |P=0.373N     P=0.181      P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.91      0/46.28      0/47.00      1/47.44      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |                                                        |2/39 (5%)    0/37 (0%)    0/39 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.444N     P=0.250N     P=0.238N     P=0.483N     | 
|POLY 3             |                                                        |P=0.467N     P=0.235N     P=0.232N     P=0.489N     | 
|POLY 1.5           |                                                        |P=0.467N     P=0.236N     P=0.234N     P=0.495N     | 
|POLY 6             |                                                        |P=0.466N     P=0.236N     P=0.231N     P=0.482N     | 
|LOGISTIC REGRESSION|                                                        |P=0.444N     (e)          (e)          P=0.483N     | 
|COCH-ARM / FISHERS |                                                        |P=0.466N     P=0.247N     P=0.247N     P=0.508N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    5/50 (10%)   4/50 (8%)    6/49 (12%)   | 
|POLY-3 RATE (b)    |                                                        |3/45.91      5/46.28      4/47.00      6/48.05      | 
|POLY-3 PERCENT (g) |                                                        |6.5%         10.8%        8.5%         12.5%        | 
|TERMINAL (d)       |                                                        |3/39 (8%)    5/37 (14%)   4/39 (10%)   5/41 (12%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.264      P=0.326      P=0.500      P=0.269      | 
|POLY 3             |                                                        |P=0.251      P=0.361      P=0.513      P=0.266      | 
|POLY 1.5           |                                                        |P=0.238      P=0.360      P=0.509      P=0.253      | 
|POLY 6             |                                                        |P=0.266      P=0.360      P=0.514      P=0.278      | 
|LOGISTIC REGRESSION|                                                        |P=0.239      P=0.326      P=0.500      P=0.218      | 
|COCH-ARM / FISHERS |                                                        |P=0.215      P=0.357      P=0.500      P=0.233      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.91      3/46.40      2/47.00      2/47.44      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         6.5%         4.3%         4.2%         | 
|TERMINAL (d)       |                                                        |2/39 (5%)    2/37 (5%)    2/39 (5%)    2/41 (5%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      701          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.492N     P=0.483      P=0.695      P=0.677N     | 
|POLY 3             |                                                        |P=0.509N     P=0.505      P=0.685N     P=0.682N     | 
|POLY 1.5           |                                                        |P=0.518N     P=0.503      P=0.688N     P=0.689N     | 
|POLY 6             |                                                        |P=0.501N     P=0.505      P=0.685N     P=0.675N     | 
|LOGISTIC REGRESSION|                                                        |P=0.490N     P=0.502      P=0.695      P=0.677N     | 
|COCH-ARM / FISHERS |                                                        |P=0.532N     P=0.500      P=0.691N     P=0.684      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/50 (74%)  36/49 (73%)  35/50 (70%)  42/50 (84%) |                                                    | 
|POLY-3 RATE (b)    |     37/47.09     36/46.93     35/48.13     42/48.22    |                                                    | 
|POLY-3 PERCENT (g) |     78.6%        76.7%        72.7%        87.1%       |                                                    | 
|TERMINAL (d)       |     26/31 (84%)  30/38 (79%)  29/38 (76%)  36/40 (90%) |                                                    | 
|FIRST INCIDENCE    |     591          490          659          496         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.398N     P=0.134N     P=0.076N     P=0.304N    |                                                    | 
|POLY 3             |     P=0.151      P=0.512N     P=0.329N     P=0.190     |                                                    | 
|POLY 1.5           |     P=0.145      P=0.529N     P=0.357N     P=0.179     |                                                    | 
|POLY 6             |     P=0.161      P=0.498N     P=0.308N     P=0.207     |                                                    | 
|LOGISTIC REGRESSION|     P=0.201      P=0.540N     P=0.205N     P=0.223     |                                                    | 
|COCH-ARM / FISHERS |     P=0.135      P=0.567N     P=0.412N     P=0.163     |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/3 (33%)    2/2 (100%)   1/1 (100%)   1/1 (100%)  |1/2 (50%)    0/0 (0%)     3/3 (100%)   1/1 (100%)   | 
|POLY-3 RATE (b)    |     1/2.99       2/2.00       1/1.00       1/1.00      |1/2.00       0/0.00       3/3.00       1/1.00       | 
|POLY-3 PERCENT (g) |     33.5%        100.0%       100.0%       100.0%      |50.0%        0.0%         100.0%       100.0%       | 
|TERMINAL (d)       |     1/2 (50%)    2/2 (100%)   1/1 (100%)   0/0 (0%)    |1/2 (50%)    0/0 (0%)     3/3 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      591         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.121      P=0.500      P=0.638      P=0.543     |P=0.314      P=1.000      P=0.419      P=0.638      | 
|POLY 3             |     P=0.225      P=0.282      P=0.501      P=0.501     |(e)          (e)          P=0.412      P=0.614      | 
|POLY 1.5           |     P=0.224      P=0.281      P=0.501      P=0.501     |(e)          (e)          P=0.412      P=0.614      | 
|POLY 6             |     P=0.226      P=0.283      P=0.502      P=0.502     |(e)          (e)          P=0.412      P=0.614      | 
|LOGISTIC REGRESSION|     P=0.326      P=0.500      P=0.638      (e)         |P=0.314      (e)          P=0.419      P=0.638      | 
|COCH-ARM / FISHERS |     P=0.214      P=0.300      P=0.500      P=0.500     |P=0.298      P=1.000      P=0.400      P=0.667      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/3 (0%)     2/2 (100%)   1/1 (100%)   0/1 (0%)    |1/2 (50%)    0/0 (0%)     3/3 (100%)   1/1 (100%)   | 
|POLY-3 RATE (b)    |     0/2.99       2/2.00       1/1.00       0/0.53      |1/2.00       0/0.00       3/3.00       1/1.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       100.0%       0.0%        |50.0%        0.0%         100.0%       100.0%       | 
|TERMINAL (d)       |     0/2 (0%)     2/2 (100%)   1/1 (100%)   0/0 (0%)    |1/2 (50%)    0/0 (0%)     3/3 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256      P=0.193      P=0.362      (e)         |P=0.314      P=1.000N     P=0.419      P=0.638      | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |(e)          (e)          P=0.412      P=0.614      | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |(e)          (e)          P=0.412      P=0.614      | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   (e)         |(e)          (e)          P=0.412      P=0.614      | 
|LOGISTIC REGRESSION|     (e)          P=0.193      P=0.362      (e)         |P=0.314      (e)          P=0.419      P=0.638      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.100      P=0.250      (e)         |P=0.298      P=1.000      P=0.400      P=0.667      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  31/50 (62%)  35/50 (70%)  29/50 (58%) |13/50 (26%)  10/50 (20%)  11/50 (22%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     29/47.19     31/45.93     35/49.38     29/47.61    |13/46.58     10/46.90     11/47.03     8/48.05      | 
|POLY-3 PERCENT (g) |     61.5%        67.5%        70.9%        60.9%       |27.9%        21.3%        23.4%        16.7%        | 
|TERMINAL (d)       |     22/31 (71%)  27/38 (71%)  26/38 (68%)  25/40 (63%) |11/39 (28%)  9/37 (24%)   10/39 (26%)  8/41 (20%)   | 
|FIRST INCIDENCE    |     378          592          523          595         |591          528          721          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.149N     P=0.340N     P=0.551      P=0.153N    |P=0.119N     P=0.363N     P=0.403N     P=0.134N     | 
|POLY 3             |     P=0.476N     P=0.343      P=0.218      P=0.563N    |P=0.139N     P=0.309N     P=0.396N     P=0.142N     | 
|POLY 1.5           |     P=0.509N     P=0.370      P=0.184      P=0.576N    |P=0.146N     P=0.311N     P=0.398N     P=0.148N     | 
|POLY 6             |     P=0.419N     P=0.329      P=0.275      P=0.528N    |P=0.133N     P=0.313N     P=0.403N     P=0.138N     | 
|LOGISTIC REGRESSION|     P=0.448N     P=0.413      P=0.162      P=0.532N    |P=0.128N     P=0.312N     P=0.379N     P=0.134N     | 
|COCH-ARM / FISHERS |     P=0.539      P=0.419      P=0.149      P=0.580N    |P=0.159N     P=0.318N     P=0.408N     P=0.163N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      0/46.53     |0/45.91      0/46.28      3/47.20      0/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         6.4%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    2/39 (5%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          676          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.556      (e)          P=0.124      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.567      (e)          P=0.124      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.558      (e)          P=0.122      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.577      (e)          P=0.125      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.542      (e)          P=0.122      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539      (e)          P=0.121      (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/49 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.85      2/44.95      3/46.77      1/46.53     |0/45.91      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     4.5%         4.5%         6.4%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    2/38 (5%)    2/38 (5%)    1/40 (3%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      679          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326N     P=0.620N     P=0.578      P=0.411N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.386N     P=0.693N     P=0.519      P=0.487N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.394N     P=0.693N     P=0.508      P=0.493N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.375N     P=0.691N     P=0.534      P=0.479N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.370N     P=0.620N     P=0.528      P=0.411N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.691N     P=0.490      P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.85      4/44.95      3/47.38      1/46.53     |1/46.58      0/46.28      0/47.00      2/48.08      | 
|POLY-3 PERCENT (g) |     0.0%         8.9%         6.3%         2.2%        |2.2%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/31 (0%)    4/38 (11%)   3/38 (8%)    1/40 (3%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |504          ---          ---          722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.509N     P=0.091      P=0.159      P=0.551     |P=0.265      P=0.496N     P=0.496N     P=0.524      | 
|POLY 3             |     P=0.573N     P=0.060      P=0.129      P=0.507     |P=0.251      P=0.501N     P=0.498N     P=0.511      | 
|POLY 1.5           |     P=0.583N     P=0.061      P=0.125      P=0.504     |P=0.249      P=0.501N     P=0.499N     P=0.507      | 
|POLY 6             |     P=0.558N     P=0.061      P=0.134      P=0.512     |P=0.253      P=0.503N     P=0.499N     P=0.514      | 
|LOGISTIC REGRESSION|     (e)          P=0.091      P=0.159      P=0.551     |P=0.177      P=0.540N     P=0.568N     P=0.380      | 
|COCH-ARM / FISHERS |     P=0.596      P=0.059      P=0.121      P=0.500     |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.85      1/45.18      0/47.38      1/46.53     |2/45.99      0/46.28      0/47.00      2/48.05      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         2.2%        |4.4%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/38 (0%)    1/40 (3%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      668          ---          729 (T)     |708          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.571N     P=0.741N     P=0.459N     P=0.704N    |P=0.521      P=0.248N     P=0.242N     P=0.673N     | 
|POLY 3             |     P=0.609N     P=0.759N     P=0.489N     P=0.752N    |P=0.507      P=0.236N     P=0.232N     P=0.678N     | 
|POLY 1.5           |     P=0.612N     P=0.760N     P=0.493N     P=0.756N    |P=0.504      P=0.236N     P=0.234N     P=0.683N     | 
|POLY 6             |     P=0.607N     P=0.757N     P=0.484N     P=0.747N    |P=0.510      P=0.236N     P=0.232N     P=0.673N     | 
|LOGISTIC REGRESSION|     P=0.612N     P=0.762N     (e)          P=0.704N    |P=0.520      P=0.236N     P=0.232N     P=0.673N     | 
|COCH-ARM / FISHERS |     P=0.616N     P=0.753N     P=0.500N     P=0.753N    |P=0.500      P=0.247N     P=0.247N     P=0.691N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |15/50 (30%)  21/50 (42%)  32/50 (64%)  40/50 (80%)  | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      0/46.53     |15/46.25     21/46.87     32/47.88     40/48.89     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |32.4%        44.8%        66.8%        81.8%        | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |13/39 (33%)  18/37 (49%)  29/39 (74%)  36/41 (88%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |655          629          633          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.116      P<0.001 **   P<0.001 **   | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.154      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.152      P<0.001 **   P<0.001 **   | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.153      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  37/50 (74%)  31/50 (62%)  18/50 (36%) |11/50 (22%)  12/50 (24%)  7/50 (14%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     28/46.81     37/48.28     31/47.93     18/46.71    |11/46.62     12/47.30     7/47.33      11/48.77     | 
|POLY-3 PERCENT (g) |     59.8%        76.6%        64.7%        38.5%       |23.6%        25.4%        14.8%        22.6%        | 
|TERMINAL (d)       |     19/31 (61%)  29/38 (76%)  27/38 (71%)  17/40 (43%) |9/39 (23%)   8/37 (22%)   6/39 (15%)   9/41 (22%)   | 
|FIRST INCIDENCE    |     591          490          668          682         |574          528          639          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.294      P=0.399N     P=0.004N**  |P=0.396N     P=0.462      P=0.216N     P=0.540N     | 
|POLY 3             |     P=0.002N**   P=0.055      P=0.389      P=0.028N*   |P=0.424N     P=0.516      P=0.206N     P=0.548N     | 
|POLY 1.5           |     P=0.002N**   P=0.051      P=0.375      P=0.030N*   |P=0.438N     P=0.511      P=0.209N     P=0.565N     | 
|POLY 6             |     P=0.002N**   P=0.061      P=0.398      P=0.028N*   |P=0.410N     P=0.518      P=0.206N     P=0.533N     | 
|LOGISTIC REGRESSION|     P=0.002N**   P=0.045 *    P=0.497      P=0.020N*   |P=0.463N     P=0.502      P=0.208N     P=0.595N     | 
|COCH-ARM / FISHERS |     P=0.004N**   P=0.046 *    P=0.342      P=0.035N*   |P=0.465N     P=0.500      P=0.218N     P=0.595N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyaline Droplet                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    23/50 (46%)  27/50 (54%)  18/50 (36%) |8/50 (16%)   41/50 (82%)  49/50 (98%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     2/45.05      23/46.41     27/47.41     18/46.91    |8/45.91      41/47.91     49/49.97     46/49.04     | 
|POLY-3 PERCENT (g) |     4.4%         49.6%        57.0%        38.4%       |17.4%        85.6%        98.1%        93.8%        | 
|TERMINAL (d)       |     1/31 (3%)    20/38 (53%)  26/38 (68%)  16/40 (40%) |8/39 (21%)   32/37 (87%)  39/39 (100%) 41/41 (100%) | 
|FIRST INCIDENCE    |     679          515          724          676         |729 (T)      577          387          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.004 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.004 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.006 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.009 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.005 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia Oncocytic                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    2/50 (4%)    4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      3/46.53     |0/45.91      2/46.28      4/47.00      6/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.5%        |0.0%         4.3%         8.5%         12.5%        | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    3/40 (8%)   |0/39 (0%)    2/37 (5%)    4/39 (10%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.016 *    (e)          (e)          P=0.169     |P=0.011 *    P=0.227      P=0.063      P=0.020 *    | 
|POLY 3             |     P=0.012 *    (e)          (e)          P=0.125     |P=0.009 **   P=0.239      P=0.063      P=0.018 *    | 
|POLY 1.5           |     P=0.011 *    (e)          (e)          P=0.123     |P=0.008 **   P=0.239      P=0.063      P=0.017 *    | 
|POLY 6             |     P=0.012 *    (e)          (e)          P=0.130     |P=0.010 *    P=0.239      P=0.063      P=0.019 *    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.169     |(e)          P=0.227      P=0.063      P=0.020 *    | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.008 **   P=0.247      P=0.059      P=0.013 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  28/50 (56%)  47/50 (94%)  46/50 (92%) |9/50 (18%)   43/50 (86%)  49/50 (98%)  50/50 (100%) | 
|POLY-3 RATE (b)    |     10/47.05     28/47.57     47/48.99     46/48.72    |9/48.05      43/49.64     49/49.15     50/50.00     | 
|POLY-3 PERCENT (g) |     21.3%        58.9%        95.9%        94.4%       |18.7%        86.6%        99.7%        100.0%       | 
|TERMINAL (d)       |     2/31 (7%)    21/38 (55%)  37/38 (97%)  39/40 (98%) |5/39 (13%)   31/37 (84%)  39/39 (100%) 41/41 (100%) | 
|FIRST INCIDENCE    |     504          515          627          496         |497          387          633          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.85      1/44.95      0/47.38      0/46.53     |3/45.99      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |6.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/38 (0%)    0/40 (0%)   |2/39 (5%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |708          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.537N     P=0.541      (e)          (e)         |P=0.046N*    P=0.131N     P=0.125N     P=0.113N     | 
|POLY 3             |     P=0.562N     P=0.500      (e)          (e)         |P=0.045N*    P=0.118N     P=0.115N     P=0.111N     | 
|POLY 1.5           |     P=0.564N     P=0.500      (e)          (e)         |P=0.045N*    P=0.118N     P=0.116N     P=0.114N     | 
|POLY 6             |     P=0.559N     P=0.502      (e)          (e)         |P=0.045N*    P=0.118N     P=0.115N     P=0.109N     | 
|LOGISTIC REGRESSION|     (e)          P=0.541      (e)          (e)         |P=0.044N*    P=0.119N     P=0.116N     P=0.111N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.047N*    P=0.121N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.85      1/44.95      0/47.38      1/46.53     |1/45.91      0/46.28      1/47.00      2/48.25      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.2%        |2.2%         0.0%         2.1%         4.2%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    0/38 (0%)    1/40 (3%)   |1/39 (3%)    0/37 (0%)    1/39 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      ---          729 (T)      676          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.448      P=0.541      (e)          P=0.551     |P=0.267      P=0.511N     P=0.762      P=0.517      | 
|POLY 3             |     P=0.416      P=0.500      (e)          P=0.507     |P=0.260      P=0.498N     P=0.755N     P=0.517      | 
|POLY 1.5           |     P=0.412      P=0.500      (e)          P=0.504     |P=0.256      P=0.499N     P=0.757N     P=0.511      | 
|POLY 6             |     P=0.423      P=0.502      (e)          P=0.512     |P=0.265      P=0.499N     P=0.755N     P=0.524      | 
|LOGISTIC REGRESSION|     (e)          P=0.541      (e)          P=0.551     |P=0.255      (e)          P=0.762      P=0.502      | 
|COCH-ARM / FISHERS |     P=0.405      P=0.500      (e)          P=0.500     |P=0.247      P=0.500N     P=0.753N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/50 (62%)  39/50 (78%)  42/50 (84%)  45/50 (90%) |44/50 (88%)  41/50 (82%)  49/50 (98%)  46/50 (92%)  | 
|POLY-3 RATE (b)    |     31/46.13     39/47.77     42/48.25     45/48.21    |44/48.41     41/47.20     49/49.84     46/49.46     | 
|POLY-3 PERCENT (g) |     67.2%        81.7%        87.0%        93.4%       |90.9%        86.9%        98.3%        93.0%        | 
|TERMINAL (d)       |     26/31 (84%)  33/38 (87%)  37/38 (97%)  40/40 (100%)|37/39 (95%)  37/37 (100%) 39/39 (100%) 39/41 (95%)  | 
|FIRST INCIDENCE    |     504          515          627          497         |497          629          387          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092      P=0.410      P=0.221      P=0.131     |P=0.493      P=0.493N     P=0.191      P=0.563N     | 
|POLY 3             |     P<0.001 **   P=0.074      P=0.013 *    P<0.001 **  |P=0.239      P=0.374N     P=0.100      P=0.494      | 
|POLY 1.5           |     P<0.001 **   P=0.067      P=0.012 *    P<0.001 **  |P=0.193      P=0.327N     P=0.080      P=0.453      | 
|POLY 6             |     P<0.001 **   P=0.090      P=0.015 *    P<0.001 **  |P=0.287      P=0.457N     P=0.121      P=0.522      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.051      P=0.039 *    P<0.001 **  |P=0.272      P=0.206N     P=0.074      P=0.552      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.063      P=0.012 *    P<0.001 **  |P=0.132      P=0.288N     P=0.056      P=0.370      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  27/50 (54%)  30/50 (60%)  32/50 (64%) |12/50 (24%)  11/50 (22%)  18/50 (36%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     20/44.85     27/44.95     30/47.41     32/47.17    |12/45.91     11/46.28     18/47.48     10/48.44     | 
|POLY-3 PERCENT (g) |     44.6%        60.1%        63.3%        67.8%       |26.1%        23.8%        37.9%        20.6%        | 
|TERMINAL (d)       |     20/31 (65%)  27/38 (71%)  29/38 (76%)  30/40 (75%) |12/39 (31%)  11/37 (30%)  16/39 (41%)  9/41 (22%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      724          595         |729 (T)      729 (T)      655          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096      P=0.375      P=0.158      P=0.131     |P=0.361N     P=0.560N     P=0.134      P=0.351N     | 
|POLY 3             |     P=0.019 *    P=0.097      P=0.049 *    P=0.016 *   |P=0.369N     P=0.491N     P=0.158      P=0.350N     | 
|POLY 1.5           |     P=0.015 *    P=0.104      P=0.043 *    P=0.014 *   |P=0.397N     P=0.493N     P=0.150      P=0.370N     | 
|POLY 6             |     P=0.027 *    P=0.093      P=0.059      P=0.022 *   |P=0.338N     P=0.493N     P=0.165      P=0.330N     | 
|LOGISTIC REGRESSION|     P=0.033 *    P=0.375      (e)          P=0.029 *   |P=0.362N     P=0.560N     P=0.144      P=0.341N     | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.115      P=0.036 *    P=0.014 *   |P=0.445N     P=0.500N     P=0.138      P=0.405N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    5/50 (10%)   1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.85      3/45.21      5/47.38      1/46.53     |0/45.91      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         6.6%         10.6%        2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    5/38 (13%)   1/40 (3%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          659          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      P=0.148      P=0.053      P=0.551     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.506      P=0.120      P=0.035 *    P=0.507     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.494      P=0.120      P=0.034 *    P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.525      P=0.122      P=0.038 *    P=0.512     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.511      P=0.121      P=0.053      P=0.551     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.477      P=0.121      P=0.028 *    P=0.500     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   5/50 (10%)   19/50 (38%) |1/50 (2%)    2/50 (4%)    7/50 (14%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     5/45.18      5/45.18      5/47.41      19/46.67    |1/46.58      2/46.28      7/47.75      9/48.67      | 
|POLY-3 PERCENT (g) |     11.1%        11.1%        10.6%        40.7%       |2.2%         4.3%         14.7%        18.5%        | 
|TERMINAL (d)       |     4/31 (13%)   4/38 (11%)   4/38 (11%)   18/40 (45%) |0/39 (0%)    2/37 (5%)    4/39 (10%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     639          668          724          693         |504          729 (T)      633          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.530N     P=0.505N     P=0.007 **  |P=0.004 **   P=0.490      P=0.039 *    P=0.015 *    | 
|POLY 3             |     P<0.001 **   P=0.630N     P=0.600N     P<0.001 **  |P=0.002 **   P=0.498      P=0.033 *    P=0.010 *    | 
|POLY 1.5           |     P<0.001 **   P=0.630N     P=0.611N     P<0.001 **  |P=0.002 **   P=0.499      P=0.032 *    P=0.009 **   | 
|POLY 6             |     P<0.001 **   P=0.628N     P=0.586N     P<0.001 **  |P=0.002 **   P=0.495      P=0.034 *    P=0.011 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.628N     P=0.580N     P=0.002 **  |P<0.001 **   P=0.483      P=0.024 *    P=0.005 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.630N     P=0.630N     P<0.001 **  |P=0.002 **   P=0.500      P=0.030 *    P=0.008 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    7/50 (14%)   10/50 (20%) |3/50 (6%)    7/50 (14%)   14/50 (28%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     6/45.69      4/45.91      7/47.41      10/46.67    |3/46.05      7/46.81      14/47.88     12/49.04     | 
|POLY-3 PERCENT (g) |     13.1%        8.7%         14.8%        21.4%       |6.5%         15.0%        29.2%        24.5%        | 
|TERMINAL (d)       |     2/31 (7%)    2/38 (5%)    6/38 (16%)   9/40 (23%)  |2/39 (5%)    5/37 (14%)   10/39 (26%)  8/41 (20%)   | 
|FIRST INCIDENCE    |     592          581          724          693         |693          577          655          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161      P=0.320N     P=0.600N     P=0.357     |P=0.019 *    P=0.152      P=0.005 **   P=0.021 *    | 
|POLY 3             |     P=0.092      P=0.366N     P=0.528      P=0.218     |P=0.013 *    P=0.164      P=0.004 **   P=0.015 *    | 
|POLY 1.5           |     P=0.090      P=0.368N     P=0.518      P=0.214     |P=0.011 *    P=0.162      P=0.003 **   P=0.013 *    | 
|POLY 6             |     P=0.096      P=0.362N     P=0.540      P=0.226     |P=0.016 *    P=0.164      P=0.004 **   P=0.017 *    | 
|LOGISTIC REGRESSION|     P=0.090      P=0.373N     P=0.520      P=0.223     |P=0.009 **   P=0.160      P=0.004 **   P=0.011 *    | 
|COCH-ARM / FISHERS |     P=0.086      P=0.370N     P=0.500      P=0.207     |P=0.009 **   P=0.159      P=0.003 **   P=0.011 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    4/50 (8%)    2/50 (4%)   |41/50 (82%)  33/50 (66%)  43/50 (86%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |     3/44.95      2/45.18      4/47.50      2/46.71     |41/46.92     33/46.84     43/49.06     49/49.78     | 
|POLY-3 PERCENT (g) |     6.7%         4.4%         8.4%         4.3%        |87.4%        70.5%        87.6%        98.4%        | 
|TERMINAL (d)       |     2/31 (7%)    1/38 (3%)    2/38 (5%)    1/40 (3%)   |38/39 (97%)  30/37 (81%)  37/39 (95%)  41/41 (100%) | 
|FIRST INCIDENCE    |     704          668          704          682         |504          639          387          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.397N     P=0.443N     P=0.597      P=0.412N    |P=0.017 *    P=0.077N     P=0.396      P=0.088      | 
|POLY 3             |     P=0.457N     P=0.498N     P=0.530      P=0.483N    |P=0.003 **   P=0.030N*    P=0.614      P=0.024 *    | 
|POLY 1.5           |     P=0.466N     P=0.499N     P=0.518      P=0.490N    |P=0.002 **   P=0.037N*    P=0.528      P=0.015 *    | 
|POLY 6             |     P=0.444N     P=0.494N     P=0.545      P=0.471N    |P=0.006 **   P=0.024N*    P=0.582N     P=0.044 *    | 
|LOGISTIC REGRESSION|     P=0.459N     P=0.498N     P=0.550      P=0.482N    |P=0.004 **   P=0.027N*    P=0.531      P=0.029 *    | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.500      P=0.500N    |P<0.001 **   P=0.055N     P=0.393      P=0.008 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    10/50 (20%)  2/50 (4%)    3/50 (6%)   |4/50 (8%)    3/50 (6%)    5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.85      10/45.83     2/47.75      3/46.53     |4/46.51      3/46.28      5/47.00      3/48.05      | 
|POLY-3 PERCENT (g) |     2.2%         21.8%        4.2%         6.5%        |8.6%         6.5%         10.6%        6.2%         | 
|TERMINAL (d)       |     1/31 (3%)    8/38 (21%)   1/38 (3%)    3/40 (8%)   |2/39 (5%)    3/37 (8%)    5/39 (13%)   3/41 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      515          627          729 (T)     |591          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327N     P=0.012 *    P=0.554      P=0.400     |P=0.443N     P=0.520N     P=0.499      P=0.474N     | 
|POLY 3             |     P=0.394N     P=0.004 **   P=0.522      P=0.319     |P=0.459N     P=0.503N     P=0.507      P=0.482N     | 
|POLY 1.5           |     P=0.408N     P=0.004 **   P=0.513      P=0.313     |P=0.467N     P=0.501N     P=0.506      P=0.488N     | 
|POLY 6             |     P=0.374N     P=0.005 **   P=0.533      P=0.327     |P=0.453N     P=0.508N     P=0.502      P=0.479N     | 
|LOGISTIC REGRESSION|     P=0.427N     P=0.005 **   P=0.478      P=0.400     |P=0.458N     P=0.500N     P=0.504      P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.430N     P=0.004 **   P=0.500      P=0.309     |P=0.482N     P=0.500N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.32      1/45.31      0/47.38      0/46.53     |1/45.91      0/46.28      1/47.19      1/48.27      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         0.0%         0.0%        |2.2%         0.0%         2.1%         2.1%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     592          627          ---          ---         |729 (T)      ---          679          672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093N     P=0.484N     P=0.213N     P=0.212N    |P=0.556      P=0.511N     P=0.758      P=0.747N     | 
|POLY 3             |     P=0.098N     P=0.500N     P=0.227N     P=0.231N    |P=0.554      P=0.498N     P=0.754N     P=0.749N     | 
|POLY 1.5           |     P=0.099N     P=0.500N     P=0.231N     P=0.234N    |P=0.548      P=0.499N     P=0.756N     P=0.753N     | 
|POLY 6             |     P=0.098N     P=0.498N     P=0.223N     P=0.227N    |P=0.560      P=0.499N     P=0.753N     P=0.745N     | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.512N     P=0.286N     P=0.261N    |P=0.519      (e)          P=0.762      P=0.756      | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.539      P=0.500N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  44/50 (88%)  42/50 (84%)  42/50 (84%) |3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     45/47.65     44/47.39     42/49.08     42/48.08    |3/45.91      1/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     94.4%        92.9%        85.6%        87.4%       |6.5%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     31/31 (100%) 38/38 (100%) 37/38 (97%)  36/40 (90%) |3/39 (8%)    1/37 (3%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     592          516          523          595         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004N**   P=0.054N     P=0.014N*    P=0.010N*   |P=0.041N*    P=0.324N     P=0.121N     P=0.112N     | 
|POLY 3             |     P=0.103N     P=0.549N     P=0.114N     P=0.177N    |P=0.042N*    P=0.302N     P=0.115N     P=0.111N     | 
|POLY 1.5           |     P=0.141N     P=0.506N     P=0.163N     P=0.209N    |P=0.042N*    P=0.303N     P=0.116N     P=0.114N     | 
|POLY 6             |     P=0.064N     P=0.677N     P=0.082N     P=0.149N    |P=0.042N*    P=0.303N     P=0.114N     P=0.108N     | 
|LOGISTIC REGRESSION|     P=0.076N     P=0.618N     P=0.089N     P=0.136N    |P=0.041N*    P=0.324N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.211N     P=0.500N     P=0.277N     P=0.277N    |P=0.044N*    P=0.309N     P=0.121N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.94      1/45.41      1/47.58      2/47.90     |2/46.49      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         2.1%         4.2%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     504          592          679          496         |574          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.563      P=0.508N     P=0.482N     P=0.691     |P=0.111N     P=0.237N     P=0.235N     P=0.225N     | 
|POLY 3             |     P=0.573      P=0.504N     P=0.488N     P=0.679N    |P=0.114N     P=0.238N     P=0.235N     P=0.230N     | 
|POLY 1.5           |     P=0.566      P=0.502N     P=0.493N     P=0.684N    |P=0.114N     P=0.237N     P=0.235N     P=0.232N     | 
|POLY 6             |     P=0.581      P=0.504N     P=0.481N     P=0.671N    |P=0.113N     P=0.240N     P=0.236N     P=0.228N     | 
|LOGISTIC REGRESSION|     P=0.373      P=0.557N     P=0.728N     P=0.620     |P=0.136N     P=0.248N     P=0.263N     P=0.311N     | 
|COCH-ARM / FISHERS |     P=0.556      P=0.500N     P=0.500N     P=0.691N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.45      0/44.95      1/47.38      1/46.62     |2/45.99      1/46.31      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     6.6%         0.0%         2.1%         2.2%        |4.4%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    1/38 (3%)    0/40 (0%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     591          ---          729 (T)      707         |708          724          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266N     P=0.117N     P=0.265N     P=0.277N    |P=0.096N     P=0.506N     P=0.242N     P=0.227N     | 
|POLY 3             |     P=0.288N     P=0.121N     P=0.291N     P=0.296N    |P=0.099N     P=0.498N     P=0.232N     P=0.228N     | 
|POLY 1.5           |     P=0.291N     P=0.120N     P=0.296N     P=0.300N    |P=0.100N     P=0.498N     P=0.234N     P=0.231N     | 
|POLY 6             |     P=0.284N     P=0.121N     P=0.284N     P=0.290N    |P=0.098N     P=0.499N     P=0.232N     P=0.225N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.122N     P=0.340N     P=0.325N    |P=0.095N     P=0.498N     P=0.232N     P=0.228N     | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.121N     P=0.309N     P=0.309N    |P=0.101N     P=0.500N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.84      0/44.95      0/47.38      1/46.93     |2/45.99      3/47.01      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     8.7%         0.0%         0.0%         2.1%        |4.4%         6.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    1/37 (3%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          ---          ---          617         |708          528          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.112N     P=0.056N     P=0.052N     P=0.156N    |P=0.070N     P=0.492      P=0.242N     P=0.227N     | 
|POLY 3             |     P=0.118N     P=0.063N     P=0.056N     P=0.172N    |P=0.068N     P=0.510      P=0.232N     P=0.228N     | 
|POLY 1.5           |     P=0.120N     P=0.062N     P=0.058N     P=0.176N    |P=0.069N     P=0.507      P=0.234N     P=0.231N     | 
|POLY 6             |     P=0.117N     P=0.063N     P=0.054N     P=0.165N    |P=0.067N     P=0.512      P=0.232N     P=0.225N     | 
|LOGISTIC REGRESSION|     P=0.176N     P=0.064N     P=0.108N     P=0.230N    |P=0.085N     P=0.490      P=0.232N     P=0.228N     | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.059N     P=0.059N     P=0.181N    |P=0.073N     P=0.500      P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   0/50 (0%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.07      0/44.95      3/47.41      0/46.53     |1/45.91      0/46.28      2/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     10.9%        0.0%         6.3%         0.0%        |2.2%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    0/38 (0%)    2/38 (5%)    0/40 (0%)   |1/39 (3%)    0/37 (0%)    2/39 (5%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          ---          724          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033N*    P=0.029N*    P=0.278N     P=0.025N*   |P=0.444N     P=0.511N     P=0.500      P=0.490N     | 
|POLY 3             |     P=0.038N*    P=0.033N*    P=0.341N     P=0.030N*   |P=0.447N     P=0.498N     P=0.508      P=0.491N     | 
|POLY 1.5           |     P=0.040N*    P=0.032N*    P=0.348N     P=0.030N*   |P=0.452N     P=0.499N     P=0.506      P=0.494N     | 
|POLY 6             |     P=0.037N*    P=0.033N*    P=0.331N     P=0.028N*   |P=0.442N     P=0.499N     P=0.509      P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.055N     P=0.033N*    P=0.460N     P=0.043N*   |P=0.444N     (e)          P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.044N*    P=0.028N*    P=0.357N     P=0.028N*   |P=0.461N     P=0.500N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  40/50 (80%)  43/50 (86%)  45/50 (90%) |44/50 (88%)  35/50 (70%)  39/50 (78%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     36/48.06     40/48.45     43/49.14     45/48.24    |44/48.54     35/47.46     39/49.46     31/49.22     | 
|POLY-3 PERCENT (g) |     74.9%        82.6%        87.5%        93.3%       |90.7%        73.8%        78.9%        63.0%        | 
|TERMINAL (d)       |     23/31 (74%)  31/38 (82%)  33/38 (87%)  38/40 (95%) |36/39 (92%)  31/37 (84%)  30/39 (77%)  26/41 (63%)  | 
|FIRST INCIDENCE    |     378          515          621          591         |497          528          387          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430      P=0.452N     P=0.562      P=0.541     |P=0.004N**   P=0.082N     P=0.214N     P=0.004N**   | 
|POLY 3             |     P=0.006 **   P=0.244      P=0.082      P=0.009 **  |P=0.002N**   P=0.022N*    P=0.084N     P<0.001N**   | 
|POLY 1.5           |     P=0.007 **   P=0.238      P=0.074      P=0.011 *   |P=0.002N**   P=0.020N*    P=0.100N     P<0.001N**   | 
|POLY 6             |     P=0.007 **   P=0.270      P=0.104      P=0.009 **  |P<0.001N**   P=0.027N*    P=0.074N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.020 *    P=0.242      P=0.100      P=0.028 *   |P=0.003N**   P=0.015N*    P=0.122N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.241      P=0.070      P=0.020 *   |P=0.006N**   P=0.024N*    P=0.143N     P=0.002N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    5/50 (10%)   4/50 (8%)   |4/50 (8%)    5/50 (10%)   4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.85      2/45.21      5/47.38      4/46.53     |4/46.42      5/46.28      4/47.16      1/48.05      | 
|POLY-3 PERCENT (g) |     6.7%         4.4%         10.6%        8.6%        |8.6%         10.8%        8.5%         2.1%         | 
|TERMINAL (d)       |     3/31 (10%)   1/38 (3%)    5/38 (13%)   4/40 (10%)  |3/39 (8%)    5/37 (14%)   3/39 (8%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      659          729 (T)      729 (T)     |574          729 (T)      687          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428      P=0.426N     P=0.472      P=0.638     |P=0.098N     P=0.472      P=0.641      P=0.168N     | 
|POLY 3             |     P=0.343      P=0.496N     P=0.387      P=0.520     |P=0.101N     P=0.498      P=0.634N     P=0.169N     | 
|POLY 1.5           |     P=0.333      P=0.498N     P=0.375      P=0.512     |P=0.104N     P=0.500      P=0.637N     P=0.172N     | 
|POLY 6             |     P=0.356      P=0.491N     P=0.402      P=0.533     |P=0.097N     P=0.493      P=0.635N     P=0.166N     | 
|LOGISTIC REGRESSION|     P=0.367      P=0.497N     P=0.472      P=0.638     |P=0.104N     P=0.503      P=0.642      P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.320      P=0.500N     P=0.357      P=0.500     |P=0.112N     P=0.500      P=0.643N     P=0.181N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/48 (10%)   2/49 (4%)    2/49 (4%)    4/49 (8%)   |4/50 (8%)    3/50 (6%)    2/48 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/42.87      2/43.95      2/47.02      4/45.67     |4/46.11      3/46.60      2/45.44      4/48.05      | 
|POLY-3 PERCENT (g) |     11.7%        4.6%         4.3%         8.8%        |8.7%         6.4%         4.4%         8.3%         | 
|TERMINAL (d)       |     5/30 (17%)   2/37 (5%)    2/38 (5%)    4/40 (10%)  |3/39 (8%)    1/37 (3%)    1/38 (3%)    3/41 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |676          675          687          728          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.386N     P=0.138N     P=0.130N     P=0.323N    |P=0.558N     P=0.520N     P=0.349N     P=0.613N     | 
|POLY 3             |     P=0.490N     P=0.205N     P=0.180N     P=0.460N    |P=0.575      P=0.494N     P=0.344N     P=0.620N     | 
|POLY 1.5           |     P=0.498N     P=0.207N     P=0.191N     P=0.472N    |P=0.568      P=0.496N     P=0.348N     P=0.628N     | 
|POLY 6             |     P=0.479N     P=0.202N     P=0.167N     P=0.442N    |P=0.576N     P=0.494N     P=0.342N     P=0.614N     | 
|LOGISTIC REGRESSION|     P=0.386N     P=0.138N     P=0.130N     P=0.323N    |P=0.571      P=0.498N     P=0.349N     P=0.613N     | 
|COCH-ARM / FISHERS |     P=0.510N     P=0.209N     P=0.209N     P=0.487N    |P=0.555      P=0.500N     P=0.359N     P=0.643N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    4/49 (8%)    3/49 (6%)    4/49 (8%)   |3/50 (6%)    1/50 (2%)    3/48 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/43.33      4/44.60      3/47.02      4/45.67     |3/45.97      1/46.28      3/45.28      1/48.20      | 
|POLY-3 PERCENT (g) |     6.9%         9.0%         6.4%         8.8%        |6.5%         2.2%         6.6%         2.1%         | 
|TERMINAL (d)       |     2/30 (7%)    3/37 (8%)    3/38 (8%)    4/40 (10%)  |2/39 (5%)    1/37 (3%)    3/38 (8%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     591          515          729 (T)      729 (T)     |712          729 (T)      729 (T)      690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567N     P=0.579      P=0.567N     P=0.632     |P=0.292N     P=0.321N     P=0.652      P=0.287N     | 
|POLY 3             |     P=0.494      P=0.516      P=0.624N     P=0.529     |P=0.298N     P=0.303N     P=0.655      P=0.289N     | 
|POLY 1.5           |     P=0.485      P=0.514      P=0.635N     P=0.521     |P=0.305N     P=0.303N     P=0.651      P=0.295N     | 
|POLY 6             |     P=0.507      P=0.520      P=0.611N     P=0.540     |P=0.291N     P=0.304N     P=0.657      P=0.283N     | 
|LOGISTIC REGRESSION|     P=0.469      P=0.507      P=0.662N     P=0.524     |P=0.293N     P=0.304N     P=0.655      P=0.295N     | 
|COCH-ARM / FISHERS |     P=0.472      P=0.512      P=0.651N     P=0.512     |P=0.315N     P=0.309N     P=0.641      P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    1/49 (2%)    2/49 (4%)    2/49 (4%)   |2/50 (4%)    4/50 (8%)    1/48 (2%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     4/43.03      1/43.95      2/47.02      2/46.06     |2/46.11      4/46.50      1/45.28      7/48.05      | 
|POLY-3 PERCENT (g) |     9.3%         2.3%         4.3%         4.3%        |4.3%         8.6%         2.2%         14.6%        | 
|TERMINAL (d)       |     2/30 (7%)    1/37 (3%)    2/38 (5%)    0/40 (0%)   |1/39 (3%)    2/37 (5%)    1/38 (3%)    6/41 (15%)   | 
|FIRST INCIDENCE    |     704          729 (T)      729 (T)      676         |676          675          729 (T)      728          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.273N     P=0.141N     P=0.253N     P=0.269N    |P=0.073      P=0.322      P=0.503N     P=0.098      | 
|POLY 3             |     P=0.319N     P=0.172N     P=0.297N     P=0.306N    |P=0.060      P=0.341      P=0.506N     P=0.089      | 
|POLY 1.5           |     P=0.327N     P=0.172N     P=0.309N     P=0.316N    |P=0.058      P=0.340      P=0.509N     P=0.086      | 
|POLY 6             |     P=0.309N     P=0.170N     P=0.284N     P=0.292N    |P=0.061      P=0.340      P=0.506N     P=0.092      | 
|LOGISTIC REGRESSION|     P=0.319N     P=0.165N     P=0.270N     P=0.322N    |P=0.066      P=0.339      P=0.511N     P=0.095      | 
|COCH-ARM / FISHERS |     P=0.336N     P=0.175N     P=0.329N     P=0.329N    |P=0.056      P=0.339      P=0.515N     P=0.080      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/48 (38%)  14/49 (29%)  30/49 (61%)  26/49 (53%) |27/50 (54%)  22/50 (44%)  24/48 (50%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |     18/44.39     14/45.27     30/48.16     26/47.51    |27/47.24     22/47.38     24/45.51     25/48.84     | 
|POLY-3 PERCENT (g) |     40.6%        30.9%        62.3%        54.7%       |57.2%        46.4%        52.7%        51.2%        | 
|TERMINAL (d)       |     14/30 (47%)  11/37 (30%)  24/38 (63%)  23/40 (58%) |23/39 (59%)  18/37 (49%)  22/38 (58%)  22/41 (54%)  | 
|FIRST INCIDENCE    |     504          515          627          496         |504          528          676          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113      P=0.120N     P=0.121      P=0.370     |P=0.349N     P=0.287N     P=0.385N     P=0.324N     | 
|POLY 3             |     P=0.023 *    P=0.231N     P=0.026 *    P=0.122     |P=0.421N     P=0.199N     P=0.413N     P=0.351N     | 
|POLY 1.5           |     P=0.019 *    P=0.233N     P=0.021 *    P=0.108     |P=0.444N     P=0.203N     P=0.414N     P=0.374N     | 
|POLY 6             |     P=0.030 *    P=0.223N     P=0.036 *    P=0.142     |P=0.400N     P=0.198N     P=0.421N     P=0.331N     | 
|LOGISTIC REGRESSION|     P=0.018 *    P=0.234N     P=0.025 *    P=0.095     |P=0.399N     P=0.199N     P=0.357N     P=0.358N     | 
|COCH-ARM / FISHERS |     P=0.015 *    P=0.236N     P=0.016 *    P=0.091     |P=0.490N     P=0.212N     P=0.423N     P=0.421N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.18      1/44.95      3/47.58      2/46.53     |0/45.91      1/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         6.3%         4.3%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    1/38 (3%)    2/38 (5%)    2/40 (5%)   |0/39 (0%)    1/37 (3%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     639          729 (T)      679          729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389      P=0.743N     P=0.359      P=0.564     |P=0.556N     P=0.489      (e)          (e)          | 
|POLY 3             |     P=0.341      P=0.760      P=0.324      P=0.510     |P=0.563N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.335      P=0.760      P=0.317      P=0.506     |P=0.564N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.351      P=0.760      P=0.333      P=0.517     |P=0.562N     P=0.501      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.330      P=0.762      P=0.278      P=0.496     |(e)          P=0.489      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.324      P=0.753N     P=0.309      P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    5/50 (10%)   3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/46.46      3/44.97      5/47.60      3/46.70     |0/45.91      1/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     15.1%        6.7%         10.5%        6.4%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/38 (5%)    3/38 (8%)    2/40 (5%)   |0/39 (0%)    1/37 (3%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     504          724          679          685         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.132N     P=0.135N     P=0.295N     P=0.125N    |P=0.556N     P=0.489      (e)          (e)          | 
|POLY 3             |     P=0.169N     P=0.171N     P=0.362N     P=0.155N    |P=0.563N     P=0.502      (e)          (e)          | 
|POLY 1.5           |     P=0.173N     P=0.165N     P=0.369N     P=0.157N    |P=0.564N     P=0.501      (e)          (e)          | 
|POLY 6             |     P=0.163N     P=0.176N     P=0.355N     P=0.152N    |P=0.562N     P=0.501      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.192N     P=0.160N     P=0.465N     P=0.185N    |(e)          P=0.489      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.179N     P=0.159N     P=0.380N     P=0.159N    |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/44.85      2/44.95      3/47.87      1/46.53     |2/45.11      1/46.29      1/47.00      1/48.08      | 
|POLY-3 PERCENT (g) |     8.9%         4.5%         6.3%         2.2%        |4.4%         2.2%         2.1%         2.1%         | 
|TERMINAL (d)       |     4/31 (13%)   2/38 (5%)    1/38 (3%)    1/40 (3%)   |1/38 (3%)    0/37 (0%)    1/39 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      621          729 (T)     |676          728          729 (T)      722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.115N     P=0.246N     P=0.406N     P=0.111N    |P=0.383N     P=0.511N     P=0.491N     P=0.472N     | 
|POLY 3             |     P=0.150N     P=0.336N     P=0.465N     P=0.168N    |P=0.395N     P=0.491N     P=0.486N     P=0.478N     | 
|POLY 1.5           |     P=0.155N     P=0.337N     P=0.479N     P=0.173N    |P=0.398N     P=0.491N     P=0.488N     P=0.483N     | 
|POLY 6             |     P=0.144N     P=0.333N     P=0.446N     P=0.160N    |P=0.391N     P=0.493N     P=0.486N     P=0.474N     | 
|LOGISTIC REGRESSION|     P=0.148N     P=0.246N     P=0.487N     P=0.111N    |P=0.391N     P=0.491N     P=0.489N     P=0.494N     | 
|COCH-ARM / FISHERS |     P=0.162N     P=0.339N     P=0.500N     P=0.181N    |P=0.404N     P=0.492N     P=0.492N     P=0.492N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.85      3/44.95      1/47.38      0/46.53     |2/45.59      3/46.72      1/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     6.7%         6.7%         2.1%         0.0%        |4.4%         6.4%         2.1%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   3/38 (8%)    1/38 (3%)    0/40 (0%)   |1/38 (3%)    1/37 (3%)    1/39 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |497          639          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032N*    P=0.566N     P=0.235N     P=0.080N    |P=0.097N     P=0.497      P=0.494N     P=0.229N     | 
|POLY 3             |     P=0.048N*    P=0.661N     P=0.286N     P=0.112N    |P=0.096N     P=0.511      P=0.489N     P=0.226N     | 
|POLY 1.5           |     P=0.049N*    P=0.662N     P=0.294N     P=0.115N    |P=0.097N     P=0.510      P=0.490N     P=0.228N     | 
|POLY 6             |     P=0.045N*    P=0.659N     P=0.276N     P=0.108N    |P=0.094N     P=0.512      P=0.490N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.032N*    P=0.566N     P=0.235N     (e)         |P=0.126N     P=0.487      P=0.536N     P=0.351N     | 
|COCH-ARM / FISHERS |     P=0.052N     P=0.661N     P=0.309N     P=0.121N    |P=0.101N     P=0.510      P=0.492N     P=0.242N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/14 (0%)    0/7 (0%)     0/7 (0%)     0/5 (0%)    |0/4 (0%)     0/8 (0%)     1/3 (33%)    3/11 (27%)   | 
|POLY-3 RATE (b)    |     0/11.17      0/6.08       0/6.69       0/4.69      |0/2.87       0/6.69       1/2.81       3/10.10      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         35.6%        29.7%        | 
|TERMINAL (d)       |     0/4 (0%)     0/4 (0%)     0/4 (0%)     0/3 (0%)    |0/2 (0%)     0/4 (0%)     1/2 (50%)    3/7 (43%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.113      (e)          P=0.500      P=0.395      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.115      (e)          P=0.496      P=0.407      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.105      (e)          P=0.478      P=0.385      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118      (e)          P=0.509      P=0.420      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.500      P=0.395      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.083      (e)          P=0.429      P=0.363      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/14 (0%)    0/7 (0%)     0/7 (0%)     0/5 (0%)    |1/4 (25%)    2/8 (25%)    1/3 (33%)    4/11 (36%)   | 
|POLY-3 RATE (b)    |     0/11.17      0/6.08       0/6.69       0/4.69      |1/2.87       2/7.02       1/2.81       4/10.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |34.9%        28.5%        35.6%        37.6%        | 
|TERMINAL (d)       |     0/4 (0%)     0/4 (0%)     0/4 (0%)     0/3 (0%)    |1/2 (50%)    1/4 (25%)    1/2 (50%)    2/7 (29%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      639          729 (T)      639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.340      P=0.666      P=0.807      P=0.444      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.495      P=0.692N     P=0.772      P=0.700      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.462      P=0.712N     P=0.747      P=0.661      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.516      P=0.669N     P=0.774N     P=0.723N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.443      P=0.729N     P=0.807      P=0.673      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.380      P=0.745N     P=0.714      P=0.593      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/14 (14%)   0/7 (0%)     1/7 (14%)    1/5 (20%)   |0/4 (0%)     0/8 (0%)     1/3 (33%)    4/11 (36%)   | 
|POLY-3 RATE (b)    |     2/11.31      0/6.08       1/6.69       1/4.69      |0/2.87       0/6.69       1/2.81       4/10.10      | 
|POLY-3 PERCENT (g) |     17.7%        0.0%         15.0%        21.3%       |0.0%         0.0%         35.6%        39.6%        | 
|TERMINAL (d)       |     0/4 (0%)     0/4 (0%)     1/4 (25%)    1/3 (33%)   |0/2 (0%)     0/4 (0%)     1/2 (50%)    4/7 (57%)    | 
|FIRST INCIDENCE    |     695          ---          729 (T)      729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522N     P=0.218N     P=0.469N     P=0.499N    |P=0.047 *    (e)          P=0.500      P=0.277      | 
|POLY 3             |     P=0.539      P=0.377N     P=0.690N     P=0.701     |P=0.046 *    (e)          P=0.496      P=0.302      | 
|POLY 1.5           |     P=0.523      P=0.384N     P=0.708N     P=0.683     |P=0.041 *    (e)          P=0.478      P=0.279      | 
|POLY 6             |     P=0.555      P=0.371N     P=0.669N     P=0.718     |P=0.046 *    (e)          P=0.509      P=0.314      | 
|LOGISTIC REGRESSION|     P=0.593      P=0.363N     P=0.643N     P=0.738     |(e)          (e)          P=0.500      P=0.277      | 
|COCH-ARM / FISHERS |     P=0.495      P=0.433N     P=0.726      P=0.624     |P=0.035 *    (e)          P=0.429      P=0.242      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/14 (7%)    0/7 (0%)     2/7 (29%)    0/5 (0%)    |0/4 (0%)     2/8 (25%)    0/3 (0%)     2/11 (18%)   | 
|POLY-3 RATE (b)    |     1/11.33      0/6.08       2/6.81       0/4.69      |0/2.87       2/6.69       0/2.81       2/10.25      | 
|POLY-3 PERCENT (g) |     8.8%         0.0%         29.4%        0.0%        |0.0%         29.9%        0.0%         19.5%        | 
|TERMINAL (d)       |     0/4 (0%)     0/4 (0%)     0/4 (0%)     0/3 (0%)    |0/2 (0%)     2/4 (50%)    0/2 (0%)     1/7 (14%)    | 
|FIRST INCIDENCE    |     687          ---          704          ---         |---          729 (T)      ---          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.431N     P=0.500N     P=0.549      P=0.485N    |P=0.500      P=0.390      (e)          P=0.380      | 
|POLY 3             |     P=0.674N     P=0.625N     P=0.310      P=0.679N    |P=0.586      P=0.436      (e)          P=0.541      | 
|POLY 1.5           |     P=0.660      P=0.629N     P=0.288      P=0.688N    |P=0.556      P=0.422      (e)          P=0.522      | 
|POLY 6             |     P=0.660N     P=0.622N     P=0.338      P=0.672N    |P=0.607      P=0.447      (e)          P=0.555      | 
|LOGISTIC REGRESSION|     P=0.668      P=0.632N     P=0.312      P=0.700N    |P=0.559      P=0.390      (e)          P=0.547      | 
|COCH-ARM / FISHERS |     P=0.624      P=0.667N     P=0.247      P=0.737N    |P=0.490      P=0.424      (e)          P=0.524      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/45 (62%)  22/48 (46%)  27/43 (63%)  26/36 (72%) |42/50 (84%)  42/50 (84%)  45/50 (90%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     28/42.99     22/46.41     27/42.98     26/34.63    |42/47.65     42/48.82     45/48.51     29/49.24     | 
|POLY-3 PERCENT (g) |     65.1%        47.4%        62.8%        75.1%       |88.2%        86.0%        92.8%        58.9%        | 
|TERMINAL (d)       |     18/29 (62%)  16/38 (42%)  19/34 (56%)  20/28 (71%) |36/39 (92%)  31/37 (84%)  38/39 (97%)  24/41 (59%)  | 
|FIRST INCIDENCE    |     504          490          523          617         |504          528          633          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.441      P=0.043N*    P=0.249N     P=0.425N    |P<0.001N**   P=0.446      P=0.325      P=0.003N**   | 
|POLY 3             |     P=0.085      P=0.067N     P=0.500N     P=0.240     |P<0.001N**   P=0.497N     P=0.324      P<0.001N**   | 
|POLY 1.5           |     P=0.083      P=0.071N     P=0.542N     P=0.238     |P<0.001N**   P=0.546N     P=0.302      P<0.001N**   | 
|POLY 6             |     P=0.094      P=0.064N     P=0.452N     P=0.253     |P<0.001N**   P=0.435N     P=0.343      P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.087      P=0.085N     P=0.565      P=0.264     |P<0.001N**   P=0.567N     P=0.439      P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.085      P=0.084N     P=0.566      P=0.239     |P<0.001N**   P=0.607N     P=0.277      P=0.004N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/6 (67%)    18/18 (100%) 7/7 (100%)   9/10 (90%)  |5/5 (100%)   1/1 (100%)   3/3 (100%)   0/0 (0%)     | 
|POLY-3 RATE (b)    |     4/5.50       18/18.00     7/7.00       9/9.83      |5/5.00       1/1.00       3/3.00       0/0.00       | 
|POLY-3 PERCENT (g) |     72.7%        100.0%       100.0%       91.6%       |100.0%       100.0%       100.0%       0.0%         | 
|TERMINAL (d)       |     3/3 (100%)   13/13 (100%) 4/4 (100%)   8/8 (100%)  |4/4 (100%)   1/1 (100%)   3/3 (100%)   0/0 (0%)     | 
|FIRST INCIDENCE    |     695          515          676          693         |591          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.333N     P=0.113      P=0.358      P=0.737N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.577      P=0.061      P=0.252      P=0.398     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.523      P=0.041 *    P=0.212      P=0.358     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.637      P=0.122      P=0.333      P=0.461     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.562      P=0.032 *    P=0.298      P=0.586     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.454      P=0.054      P=0.192      P=0.304     |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   9/50 (18%)   1/50 (2%)   |3/50 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/45.02      6/44.95      9/47.97      1/46.53     |3/45.91      2/46.49      2/47.00      2/48.05      | 
|POLY-3 PERCENT (g) |     11.1%        13.4%        18.8%        2.2%        |6.5%         4.3%         4.3%         4.2%         | 
|TERMINAL (d)       |     4/31 (13%)   6/38 (16%)   7/38 (18%)   1/40 (3%)   |3/39 (8%)    1/37 (3%)    2/39 (5%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     687          729 (T)      621          729 (T)     |729 (T)      675          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061N     P=0.625N     P=0.308      P=0.061N    |P=0.402N     P=0.521N     P=0.500N     P=0.477N     | 
|POLY 3             |     P=0.094N     P=0.499      P=0.230      P=0.094N    |P=0.416N     P=0.494N     P=0.489N     P=0.479N     | 
|POLY 1.5           |     P=0.101N     P=0.500      P=0.215      P=0.097N    |P=0.421N     P=0.496N     P=0.493N     P=0.487N     | 
|POLY 6             |     P=0.085N     P=0.501      P=0.250      P=0.089N    |P=0.410N     P=0.493N     P=0.488N     P=0.473N     | 
|LOGISTIC REGRESSION|     P=0.091N     P=0.527      P=0.220      P=0.085N    |P=0.403N     P=0.497N     P=0.500N     P=0.477N     | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.500      P=0.194      P=0.102N    |P=0.431N     P=0.500N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   8/50 (16%)   8/50 (16%)   3/50 (6%)   |5/50 (10%)   4/50 (8%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     7/46.18      8/45.21      8/47.77      3/46.53     |5/46.51      4/46.51      2/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     15.2%        17.7%        16.8%        6.5%        |10.8%        8.6%         4.3%         0.0%         | 
|TERMINAL (d)       |     5/31 (16%)   7/38 (18%)   7/38 (18%)   3/40 (8%)   |3/39 (8%)    2/37 (5%)    2/39 (5%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          659          621          729 (T)     |591          675          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.058N     P=0.588N     P=0.580N     P=0.091N    |P=0.015N*    P=0.518N     P=0.221N     P=0.032N*    | 
|POLY 3             |     P=0.105N     P=0.482      P=0.528      P=0.154N    |P=0.014N*    P=0.500N     P=0.212N     P=0.028N*    | 
|POLY 1.5           |     P=0.109N     P=0.488      P=0.516      P=0.157N    |P=0.014N*    P=0.499N     P=0.213N     P=0.029N*    | 
|POLY 6             |     P=0.098N     P=0.483      P=0.547      P=0.148N    |P=0.013N*    P=0.504N     P=0.214N     P=0.027N*    | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.499      P=0.421      P=0.181N    |P=0.016N*    P=0.500N     P=0.218N     P=0.037N*    | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.500      P=0.500      P=0.159N    |P=0.016N*    P=0.500N     P=0.218N     P=0.028N*    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   5/50 (10%)   0/50 (0%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/45.36      6/44.95      5/47.38      0/46.53     |1/45.91      0/46.28      3/47.00      1/48.05      | 
|POLY-3 PERCENT (g) |     11.0%        13.4%        10.6%        0.0%        |2.2%         0.0%         6.4%         2.1%         | 
|TERMINAL (d)       |     3/31 (10%)   6/38 (16%)   5/38 (13%)   0/40 (0%)   |1/39 (3%)    0/37 (0%)    3/39 (8%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     639          729 (T)      729 (T)      ---         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.013N*    P=0.610      P=0.516N     P=0.022N*   |P=0.493      P=0.511N     P=0.305      P=0.751N     | 
|POLY 3             |     P=0.022N*    P=0.494      P=0.603N     P=0.028N*   |P=0.493      P=0.498N     P=0.314      P=0.750N     | 
|POLY 1.5           |     P=0.023N*    P=0.497      P=0.613N     P=0.029N*   |P=0.484      P=0.499N     P=0.311      P=0.754N     | 
|POLY 6             |     P=0.020N*    P=0.491      P=0.591N     P=0.027N*   |P=0.501      P=0.499N     P=0.314      P=0.747N     | 
|LOGISTIC REGRESSION|     P=0.020N*    P=0.505      P=0.597N     P=0.033N*   |P=0.493      (e)          P=0.305      P=0.751N     | 
|COCH-ARM / FISHERS |     P=0.026N*    P=0.500      P=0.630N     P=0.028N*   |P=0.469      P=0.500N     P=0.309      P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.85      4/44.95      1/47.38      0/46.53     |0/45.91      2/46.51      1/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         8.9%         2.1%         0.0%        |0.0%         4.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    4/38 (11%)   1/38 (3%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    1/39 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          675          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238N     P=0.091      P=0.541      (e)         |P=0.443N     P=0.240      P=0.500      (e)          | 
|POLY 3             |     P=0.277N     P=0.060      P=0.511      (e)         |P=0.444N     P=0.240      P=0.505      (e)          | 
|POLY 1.5           |     P=0.284N     P=0.061      P=0.507      (e)         |P=0.450N     P=0.239      P=0.503      (e)          | 
|POLY 6             |     P=0.267N     P=0.061      P=0.516      (e)         |P=0.439N     P=0.241      P=0.505      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.091      P=0.541      (e)         |P=0.460N     P=0.237      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.059      P=0.500      (e)         |P=0.461N     P=0.247      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/50 (18%)   11/50 (22%)  3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |9/46.12      11/46.31     3/47.20      6/48.20      | 
|POLY-3 PERCENT (g) |                                                        |19.5%        23.8%        6.4%         12.5%        | 
|TERMINAL (d)       |                                                        |7/39 (18%)   10/37 (27%)  2/39 (5%)    5/41 (12%)   | 
|FIRST INCIDENCE    |                                                        |695          724          676          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.096N     P=0.360      P=0.067N     P=0.257N     | 
|POLY 3             |                                                        |P=0.098N     P=0.404      P=0.054N     P=0.257N     | 
|POLY 1.5           |                                                        |P=0.104N     P=0.405      P=0.056N     P=0.268N     | 
|POLY 6             |                                                        |P=0.093N     P=0.399      P=0.053N     P=0.247N     | 
|LOGISTIC REGRESSION|                                                        |P=0.091N     P=0.399      P=0.056N     P=0.247N     | 
|COCH-ARM / FISHERS |                                                        |P=0.117N     P=0.402      P=0.061N     P=0.288N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  18/50 (36%)  16/49 (33%)  7/50 (14%)  |3/50 (6%)    1/50 (2%)    8/50 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     12/45.82     18/45.83     16/46.86     7/47.39     |3/45.97      1/46.28      8/47.60      4/48.27      | 
|POLY-3 PERCENT (g) |     26.2%        39.3%        34.2%        14.8%       |6.5%         2.2%         16.8%        8.3%         | 
|TERMINAL (d)       |     8/31 (26%)   16/38 (42%)  14/38 (37%)  5/40 (13%)  |2/39 (5%)    1/37 (3%)    6/39 (15%)   3/41 (7%)    | 
|FIRST INCIDENCE    |     504          516          659          591         |712          729 (T)      639          672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.021N*    P=0.296      P=0.463      P=0.076N    |P=0.281      P=0.321N     P=0.109      P=0.532      | 
|POLY 3             |     P=0.047N*    P=0.130      P=0.271      P=0.132N    |P=0.271      P=0.303N     P=0.110      P=0.526      | 
|POLY 1.5           |     P=0.055N     P=0.133      P=0.255      P=0.141N    |P=0.259      P=0.303N     P=0.106      P=0.517      | 
|POLY 6             |     P=0.038N*    P=0.130      P=0.294      P=0.119N    |P=0.284      P=0.304N     P=0.113      P=0.536      | 
|LOGISTIC REGRESSION|     P=0.057N     P=0.137      P=0.287      P=0.157N    |P=0.252      P=0.304N     P=0.104      P=0.522      | 
|COCH-ARM / FISHERS |     P=0.069N     P=0.138      P=0.232      P=0.154N    |P=0.240      P=0.309N     P=0.100      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.85      2/44.95      2/46.58      1/46.53     |0/45.91      0/46.28      1/47.00      1/48.05      | 
|POLY-3 PERCENT (g) |     2.2%         4.5%         4.3%         2.2%        |0.0%         0.0%         2.1%         2.1%         | 
|TERMINAL (d)       |     1/31 (3%)    2/38 (5%)    2/38 (5%)    1/40 (3%)   |0/39 (0%)    0/37 (0%)    1/39 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.479N     P=0.571      P=0.571      P=0.704N    |P=0.250      (e)          P=0.500      P=0.510      | 
|POLY 3             |     P=0.539N     P=0.501      P=0.513      P=0.752N    |P=0.249      (e)          P=0.505      P=0.509      | 
|POLY 1.5           |     P=0.546N     P=0.500      P=0.505      P=0.756N    |P=0.245      (e)          P=0.503      P=0.506      | 
|POLY 6             |     P=0.529N     P=0.503      P=0.524      P=0.747N    |P=0.254      (e)          P=0.505      P=0.512      | 
|LOGISTIC REGRESSION|     P=0.479N     P=0.571      P=0.571      P=0.704N    |(e)          (e)          P=0.500      P=0.510      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.492      P=0.753N    |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/47 (4%)    1/49 (2%)    1/45 (2%)   |4/50 (8%)    5/50 (10%)   7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/43.32      2/42.88      1/46.38      1/42.20     |4/46.69      5/46.31      7/47.19      7/48.27      | 
|POLY-3 PERCENT (g) |     2.3%         4.7%         2.2%         2.4%        |8.6%         10.8%        14.8%        14.5%        | 
|TERMINAL (d)       |     1/30 (3%)    2/38 (5%)    1/37 (3%)    1/37 (3%)   |2/39 (5%)    3/37 (8%)    6/39 (15%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |574          724          679          672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481N     P=0.583      P=0.715N     P=0.715N    |P=0.240      P=0.482      P=0.269      P=0.295      | 
|POLY 3             |     P=0.536N     P=0.496      P=0.745N     P=0.755     |P=0.217      P=0.495      P=0.267      P=0.281      | 
|POLY 1.5           |     P=0.541N     P=0.495      P=0.749N     P=0.751     |P=0.210      P=0.498      P=0.267      P=0.275      | 
|POLY 6             |     P=0.528N     P=0.500      P=0.740N     P=0.761     |P=0.224      P=0.488      P=0.264      P=0.285      | 
|LOGISTIC REGRESSION|     P=0.481N     P=0.583      P=0.715N     P=0.715N    |P=0.207      P=0.499      P=0.257      P=0.238      | 
|COCH-ARM / FISHERS |     P=0.550N     P=0.492      P=0.747N     P=0.736     |P=0.194      P=0.500      P=0.262      P=0.262      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    8/47 (17%)   7/49 (14%)   8/45 (18%)  |22/50 (44%)  13/50 (26%)  18/50 (36%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/43.32      8/43.29      7/46.96      8/42.75     |22/48.45     13/46.77     18/48.22     6/48.05      | 
|POLY-3 PERCENT (g) |     9.2%         18.5%        14.9%        18.7%       |45.4%        27.8%        37.3%        12.5%        | 
|TERMINAL (d)       |     4/30 (13%)   7/38 (18%)   5/37 (14%)   6/37 (16%)  |16/39 (41%)  10/37 (27%)  15/39 (39%)  6/41 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      611          621          595         |380          659          387          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.297      P=0.296      P=0.377      P=0.281     |P<0.001N**   P=0.077N     P=0.285N     P<0.001N**   | 
|POLY 3             |     P=0.207      P=0.175      P=0.309      P=0.169     |P<0.001N**   P=0.056N     P=0.274N     P<0.001N**   | 
|POLY 1.5           |     P=0.193      P=0.171      P=0.295      P=0.159     |P<0.001N**   P=0.052N     P=0.271N     P<0.001N**   | 
|POLY 6             |     P=0.229      P=0.182      P=0.328      P=0.184     |P<0.001N**   P=0.062N     P=0.287N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.189      P=0.175      P=0.297      P=0.164     |P<0.001N**   P=0.048N*    P=0.299N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.175      P=0.167      P=0.274      P=0.147     |P<0.001N**   P=0.046N*    P=0.270N     P<0.001N**   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    5/47 (11%)   9/49 (18%)   7/45 (16%)  |10/50 (20%)  12/50 (24%)  8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     4/43.42      5/42.88      9/47.19      7/42.20     |10/46.97     12/46.64     8/48.39      7/48.05      | 
|POLY-3 PERCENT (g) |     9.2%         11.7%        19.1%        16.6%       |21.3%        25.7%        16.5%        14.6%        | 
|TERMINAL (d)       |     3/30 (10%)   5/38 (13%)   6/37 (16%)   7/37 (19%)  |8/39 (21%)   8/37 (22%)   5/39 (13%)   7/41 (17%)   | 
|FIRST INCIDENCE    |     704          729 (T)      621          729 (T)     |380          675          387          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.262      P=0.633      P=0.203      P=0.385     |P=0.141N     P=0.371      P=0.396N     P=0.263N     | 
|POLY 3             |     P=0.173      P=0.492      P=0.150      P=0.243     |P=0.151N     P=0.397      P=0.371N     P=0.279N     | 
|POLY 1.5           |     P=0.164      P=0.490      P=0.139      P=0.236     |P=0.158N     P=0.399      P=0.380N     P=0.286N     | 
|POLY 6             |     P=0.187      P=0.497      P=0.164      P=0.256     |P=0.145N     P=0.395      P=0.364N     P=0.273N     | 
|LOGISTIC REGRESSION|     P=0.178      P=0.530      P=0.130      P=0.296     |P=0.189N     P=0.407      P=0.454N     P=0.314N     | 
|COCH-ARM / FISHERS |     P=0.152      P=0.486      P=0.124      P=0.225     |P=0.170N     P=0.405      P=0.398N     P=0.298N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/49 (0%)    0/45 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.32      0/42.88      0/46.38      0/42.20     |0/45.91      0/46.28      2/47.28      2/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.2%         4.2%         | 
|TERMINAL (d)       |     0/30 (0%)    0/38 (0%)    0/37 (0%)    0/37 (0%)   |0/39 (0%)    0/37 (0%)    1/39 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          655          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.098      (e)          P=0.245      P=0.249      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.094      (e)          P=0.244      P=0.248      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.091      (e)          P=0.242      P=0.244      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.097      (e)          P=0.245      P=0.251      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.086      (e)          P=0.229      P=0.249      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.086      (e)          P=0.247      P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     39/50 (78%)  39/49 (80%)  45/50 (90%)  45/50 (90%) |                                                    | 
|POLY-3 RATE (b)    |     39/48.40     39/46.73     45/49.41     45/48.10    |                                                    | 
|POLY-3 PERCENT (g) |     80.6%        83.5%        91.1%        93.6%       |                                                    | 
|TERMINAL (d)       |     24/31 (77%)  32/38 (84%)  35/38 (92%)  39/40 (98%) |                                                    | 
|FIRST INCIDENCE    |     504          581          523          591         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.478N     P=0.197N     P=0.479N     P=0.368N    |                                                    | 
|POLY 3             |     P=0.020 *    P=0.460      P=0.107      P=0.045 *   |                                                    | 
|POLY 1.5           |     P=0.027 *    P=0.490      P=0.100      P=0.059     |                                                    | 
|POLY 6             |     P=0.015 *    P=0.427      P=0.109      P=0.032 *   |                                                    | 
|LOGISTIC REGRESSION|     P=0.060      P=0.552      P=0.127      P=0.116     |                                                    | 
|COCH-ARM / FISHERS |     P=0.039 *    P=0.521      P=0.086      P=0.086     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  29/50 (58%)  24/50 (48%)  18/50 (36%) |                                                    | 
|POLY-3 RATE (b)    |     27/48.20     29/47.37     24/49.16     18/47.19    |                                                    | 
|POLY-3 PERCENT (g) |     56.0%        61.2%        48.8%        38.1%       |                                                    | 
|TERMINAL (d)       |     14/31 (45%)  24/38 (63%)  17/38 (45%)  15/40 (38%) |                                                    | 
|FIRST INCIDENCE    |     378          490          523          617         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.005N**   P=0.431N     P=0.155N     P=0.016N*   |                                                    | 
|POLY 3             |     P=0.020N*    P=0.378      P=0.305N     P=0.058N    |                                                    | 
|POLY 1.5           |     P=0.020N*    P=0.395      P=0.322N     P=0.056N    |                                                    | 
|POLY 6             |     P=0.019N*    P=0.360      P=0.285N     P=0.059N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.021N*    P=0.420      P=0.432N     P=0.055N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.020N*    P=0.420      P=0.345N     P=0.054N    |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  11/50 (22%)  7/50 (14%)   1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     12/45.44     11/45.31     7/47.38      1/46.53     |                                                    | 
|POLY-3 PERCENT (g) |     26.4%        24.3%        14.8%        2.2%        |                                                    | 
|TERMINAL (d)       |     8/31 (26%)   10/38 (26%)  7/38 (18%)   1/40 (3%)   |                                                    | 
|FIRST INCIDENCE    |     639          627          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.331N     P=0.075N     P<0.001N**  |                                                    | 
|POLY 3             |     P<0.001N**   P=0.503N     P=0.128N     P<0.001N**  |                                                    | 
|POLY 1.5           |     P<0.001N**   P=0.501N     P=0.137N     P<0.001N**  |                                                    | 
|POLY 6             |     P<0.001N**   P=0.502N     P=0.118N     P<0.001N**  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.493N     P=0.105N     P<0.001N**  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001N**   P=0.500N     P=0.154N     P<0.001N**  |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.32      0/44.95      0/47.38      1/46.53     |1/45.91      0/46.28      0/47.00      2/48.25      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.2%        |2.2%         0.0%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    1/40 (3%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     591          ---          ---          729 (T)     |729 (T)      ---          ---          676          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617      P=0.508N     P=0.496N     P=0.732N    |P=0.263      P=0.511N     P=0.500N     P=0.517      | 
|POLY 3             |     P=0.601      P=0.502N     P=0.491N     P=0.755N    |P=0.252      P=0.498N     P=0.495N     P=0.517      | 
|POLY 1.5           |     P=0.598      P=0.501N     P=0.495N     P=0.757N    |P=0.250      P=0.499N     P=0.497N     P=0.511      | 
|POLY 6             |     P=0.604      P=0.502N     P=0.487N     P=0.751N    |P=0.255      P=0.499N     P=0.495N     P=0.524      | 
|LOGISTIC REGRESSION|     P=0.559      P=0.536N     P=0.648N     P=0.739     |P=0.247      (e)          (e)          P=0.502      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.246      P=0.500N     P=0.500N     P=0.500      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/45.18      0/44.95      0/47.38      0/46.53     |1/45.91      1/46.28      0/47.00      0/47.05      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |2.2%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    1/37 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     639          ---          ---          ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.102N     P=0.222N     P=0.208N     P=0.207N    |P=0.231N     P=0.750      P=0.500N     P=0.495N     | 
|POLY 3             |     P=0.112N     P=0.238N     P=0.227N     P=0.231N    |P=0.236N     P=0.759N     P=0.495N     P=0.495N     | 
|POLY 1.5           |     P=0.113N     P=0.238N     P=0.231N     P=0.233N    |P=0.237N     P=0.759N     P=0.497N     P=0.498N     | 
|POLY 6             |     P=0.112N     P=0.238N     P=0.222N     P=0.227N    |P=0.236N     P=0.759N     P=0.495N     P=0.492N     | 
|LOGISTIC REGRESSION|     P=0.122N     P=0.238N     P=0.259N     P=0.247N    |P=0.231N     P=0.750      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.238N     P=0.753N     P=0.500N     P=0.505N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      0/46.53     |1/45.91      2/46.28      0/47.00      2/47.27      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.3%         0.0%         4.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    2/37 (5%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.487      P=0.482      P=0.500N     P=0.513      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.478      P=0.503      P=0.495N     P=0.510      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.472      P=0.502      P=0.497N     P=0.504      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.483      P=0.502      P=0.495N     P=0.516      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.476      P=0.482      (e)          P=0.493      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.462      P=0.500      P=0.500N     P=0.492      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      0/46.53     |1/45.91      3/46.28      0/47.00      1/47.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.5%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    3/37 (8%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.396N     P=0.286      P=0.500N     P=0.756N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.404N     P=0.308      P=0.495N     P=0.755N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.408N     P=0.308      P=0.497N     P=0.758N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.400N     P=0.308      P=0.495N     P=0.752N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.396N     P=0.286      (e)          P=0.756N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.416N     P=0.309      P=0.500N     P=0.747      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.85      4/45.21      2/47.38      4/47.00     |1/45.99      1/46.28      1/47.20      1/48.05      | 
|POLY-3 PERCENT (g) |     6.7%         8.9%         4.2%         8.5%        |2.2%         2.2%         2.1%         2.1%         | 
|TERMINAL (d)       |     3/31 (10%)   3/38 (8%)    2/38 (5%)    3/40 (8%)   |0/39 (0%)    1/37 (3%)    0/39 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      659          729 (T)      591         |708          729 (T)      676          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.571N     P=0.594      P=0.407N     P=0.617     |P=0.611N     P=0.752      P=0.760      P=0.747N     | 
|POLY 3             |     P=0.508      P=0.504      P=0.475N     P=0.525     |P=0.622N     P=0.759N     P=0.755N     P=0.751N     | 
|POLY 1.5           |     P=0.497      P=0.502      P=0.485N     P=0.515     |P=0.626N     P=0.759N     P=0.757N     P=0.754N     | 
|POLY 6             |     P=0.524      P=0.510      P=0.463N     P=0.542     |P=0.619N     P=0.760N     P=0.754N     P=0.748N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.506      P=0.407N     P=0.511     |P=0.632N     P=0.761N     P=0.756      P=0.754N     | 
|COCH-ARM / FISHERS |     P=0.481      P=0.500      P=0.500N     P=0.500     |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   13/50 (26%)  19/50 (38%)  25/50 (50%) |26/50 (52%)  26/50 (52%)  45/50 (90%)  43/50 (86%)  | 
|POLY-3 RATE (b)    |     9/46.50      13/46.86     19/48.19     25/48.55    |26/48.05     26/46.57     45/49.41     43/49.75     | 
|POLY-3 PERCENT (g) |     19.4%        27.8%        39.4%        51.5%       |54.1%        55.8%        91.1%        86.4%        | 
|TERMINAL (d)       |     4/31 (13%)   8/38 (21%)   14/38 (37%)  21/40 (53%) |21/39 (54%)  23/37 (62%)  38/39 (97%)  37/41 (90%)  | 
|FIRST INCIDENCE    |     504          592          621          496         |497          659          387          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.339      P=0.084      P=0.010 *   |P<0.001 **   P=0.487      P<0.001 **   P=0.003 **   | 
|POLY 3             |     P<0.001 **   P=0.239      P=0.025 *    P<0.001 **  |P<0.001 **   P=0.516      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.236      P=0.024 *    P<0.001 **  |P<0.001 **   P=0.546      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.247      P=0.028 *    P<0.001 **  |P<0.001 **   P=0.470      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.230      P=0.019 *    P<0.001 **  |P<0.001 **   P=0.564N     P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.235      P=0.022 *    P<0.001 **  |P<0.001 **   P=0.579N     P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   12/50 (24%)  24/50 (48%)  38/50 (76%) |24/50 (48%)  32/50 (64%)  45/50 (90%)  48/50 (96%)  | 
|POLY-3 RATE (b)    |     9/45.81      12/46.18     24/49.13     38/48.85    |24/47.40     32/47.20     45/48.44     48/49.39     | 
|POLY-3 PERCENT (g) |     19.7%        26.0%        48.9%        77.8%       |50.6%        67.8%        92.9%        97.2%        | 
|TERMINAL (d)       |     5/31 (16%)   9/38 (24%)   18/38 (47%)  32/40 (80%) |19/39 (49%)  28/37 (76%)  38/39 (97%)  41/41 (100%) | 
|FIRST INCIDENCE    |     591          515          523          497         |504          629          639          532          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.446      P=0.013 *    P<0.001 **  |P<0.001 **   P=0.057      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.317      P=0.002 **   P<0.001 **  |P<0.001 **   P=0.064      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.316      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.069      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.322      P=0.003 **   P<0.001 **  |P<0.001 **   P=0.057      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.312      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.082      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.312      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.079      P<0.001 **   P<0.001 **   | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.18      2/45.80      1/47.48      0/46.53     |1/45.91      1/46.55      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     4.3%         4.4%         2.1%         0.0%        |2.2%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          581          704          ---         |729 (T)      659          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122N     P=0.682      P=0.483N     P=0.240N    |P=0.227N     P=0.754      P=0.500N     P=0.490N     | 
|POLY 3             |     P=0.124N     P=0.691      P=0.490N     P=0.235N    |P=0.234N     P=0.757N     P=0.495N     P=0.491N     | 
|POLY 1.5           |     P=0.125N     P=0.691      P=0.495N     P=0.237N    |P=0.235N     P=0.758N     P=0.497N     P=0.494N     | 
|POLY 6             |     P=0.122N     P=0.694      P=0.484N     P=0.232N    |P=0.233N     P=0.757N     P=0.495N     P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.205N     P=0.699      P=0.726      P=0.355N    |P=0.244N     P=0.761      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.236N     P=0.753N     P=0.500N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.57      1/45.44      1/47.48      1/46.67     |2/46.71      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     8.6%         2.2%         2.1%         2.1%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          581          704          693         |504          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.127N     P=0.186N     P=0.164N     P=0.172N    |P=0.114N     P=0.237N     P=0.243N     P=0.230N     | 
|POLY 3             |     P=0.130N     P=0.186N     P=0.173N     P=0.178N    |P=0.113N     P=0.239N     P=0.236N     P=0.231N     | 
|POLY 1.5           |     P=0.132N     P=0.184N     P=0.176N     P=0.179N    |P=0.114N     P=0.238N     P=0.236N     P=0.233N     | 
|POLY 6             |     P=0.128N     P=0.187N     P=0.169N     P=0.175N    |P=0.113N     P=0.241N     P=0.237N     P=0.230N     | 
|LOGISTIC REGRESSION|     P=0.206N     P=0.165N     P=0.364N     P=0.239N    |P=0.150N     P=0.254N     P=0.276N     P=0.377N     | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.181N     P=0.181N     P=0.181N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.35      2/45.80      3/48.08      2/46.76     |3/46.66      2/46.65      1/47.19      0/48.05      | 
|POLY-3 PERCENT (g) |     4.4%         4.4%         6.2%         4.3%        |6.4%         4.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |1/39 (3%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     591          581          627          693         |504          659          679          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.580N     P=0.691      P=0.543      P=0.659N    |P=0.059N     P=0.505N     P=0.311N     P=0.115N     | 
|POLY 3             |     P=0.585      P=0.690N     P=0.527      P=0.683N    |P=0.059N     P=0.500N     P=0.301N     P=0.114N     | 
|POLY 1.5           |     P=0.578      P=0.692N     P=0.516      P=0.687N    |P=0.060N     P=0.500N     P=0.303N     P=0.115N     | 
|POLY 6             |     P=0.589N     P=0.687N     P=0.541      P=0.675N    |P=0.058N     P=0.501N     P=0.302N     P=0.112N     | 
|LOGISTIC REGRESSION|     P=0.490      P=0.681      P=0.385      P=0.672     |P=0.081N     P=0.519N     P=0.342N     P=0.172N     | 
|COCH-ARM / FISHERS |     P=0.569      P=0.691N     P=0.500      P=0.691N    |P=0.062N     P=0.500N     P=0.309N     P=0.121N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/46.43      1/45.41      0/47.38      2/47.31     |0/45.91      2/46.42      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     10.8%        2.2%         0.0%         4.2%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     378          592          ---          496         |---          701          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152N     P=0.106N     P=0.030N*    P=0.195N    |P=0.391N     P=0.245      (e)          (e)          | 
|POLY 3             |     P=0.156N     P=0.106N     P=0.029N*    P=0.209N    |P=0.394N     P=0.240      (e)          (e)          | 
|POLY 1.5           |     P=0.159N     P=0.105N     P=0.030N*    P=0.213N    |P=0.398N     P=0.239      (e)          (e)          | 
|POLY 6             |     P=0.154N     P=0.107N     P=0.028N*    P=0.203N    |P=0.392N     P=0.240      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.250N     P=0.098N     P=0.071N     P=0.284N    |P=0.401N     P=0.239      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165N     P=0.102N     P=0.028N*    P=0.218N    |P=0.405N     P=0.247      (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.68      0/44.95      0/47.38      1/46.67     |0/45.91      0/46.28      0/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     591          ---          ---          693         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.249N     P=0.230N     P=0.488N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.456N     P=0.241N     P=0.229N     P=0.493N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.458N     P=0.239N     P=0.232N     P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.454N     P=0.242N     P=0.226N     P=0.488N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.532N     P=0.255N     P=0.353N     P=0.566N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247N     P=0.247N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   11/50 (22%)  8/50 (16%)   30/50 (60%) |                                                    | 
|POLY-3 RATE (b)    |     7/45.70      11/45.44     8/47.84      30/48.52    |                                                    | 
|POLY-3 PERCENT (g) |     15.3%        24.2%        16.7%        61.8%       |                                                    | 
|TERMINAL (d)       |     3/31 (10%)   9/38 (24%)   6/38 (16%)   25/40 (63%) |                                                    | 
|FIRST INCIDENCE    |     591          659          659          496         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.328      P=0.589N     P<0.001 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.211      P=0.538      P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.214      P=0.524      P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.210      P=0.555      P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.218      P=0.497      P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.218      P=0.500      P<0.001 **  |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   15/50 (30%)  7/50 (14%)   23/50 (46%) |                                                    | 
|POLY-3 RATE (b)    |     7/45.64      15/46.91     7/48.24      23/47.66    |                                                    | 
|POLY-3 PERCENT (g) |     15.3%        32.0%        14.5%        48.3%       |                                                    | 
|TERMINAL (d)       |     4/31 (13%)   10/38 (26%)  4/38 (11%)   20/40 (50%) |                                                    | 
|FIRST INCIDENCE    |     591          515          627          591         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.099      P=0.494N     P=0.006 **  |                                                    | 
|POLY 3             |     P<0.001 **   P=0.049 *    P=0.570N     P<0.001 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.046 *    P=0.587N     P<0.001 **  |                                                    | 
|POLY 6             |     P<0.001 **   P=0.053      P=0.548N     P<0.001 **  |                                                    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.045 *    P=0.575      P<0.001 **  |                                                    | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.045 *    P=0.613N     P<0.001 **  |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/47 (0%)    2/44 (5%)    0/46 (0%)   |0/48 (0%)    1/48 (2%)    0/45 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.95      0/42.44      2/42.16      0/42.53     |0/43.91      1/44.40      0/42.41      1/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.7%         0.0%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/31 (0%)    0/36 (0%)    2/36 (6%)    0/36 (0%)   |0/37 (0%)    1/36 (3%)    0/36 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.619      (e)          P=0.272      (e)         |P=0.430      P=0.495      (e)          P=0.520      | 
|POLY 3             |     P=0.594      (e)          P=0.228      (e)         |P=0.428      P=0.502      (e)          P=0.518      | 
|POLY 1.5           |     P=0.589      (e)          P=0.222      (e)         |P=0.423      P=0.502      (e)          P=0.514      | 
|POLY 6             |     P=0.602      (e)          P=0.235      (e)         |P=0.433      P=0.502      (e)          P=0.521      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.272      (e)         |(e)          P=0.495      (e)          P=0.520      | 
|COCH-ARM / FISHERS |     P=0.581      (e)          P=0.221      (e)         |P=0.414      P=0.500      (e)          P=0.510      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.85      0/44.95      0/47.38      2/47.22     |0/45.91      0/46.28      1/47.28      2/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.2%        |0.0%         0.0%         2.1%         4.2%         | 
|TERMINAL (d)       |     0/31 (0%)    0/38 (0%)    0/38 (0%)    1/40 (3%)   |0/39 (0%)    0/37 (0%)    0/39 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          496         |---          ---          655          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.053      (e)          (e)          P=0.270     |P=0.079      (e)          P=0.509      P=0.249      | 
|POLY 3             |     P=0.048 *    (e)          (e)          P=0.249     |P=0.075      (e)          P=0.506      P=0.248      | 
|POLY 1.5           |     P=0.047 *    (e)          (e)          P=0.244     |P=0.073      (e)          P=0.504      P=0.244      | 
|POLY 6             |     P=0.049 *    (e)          (e)          P=0.255     |P=0.077      (e)          P=0.507      P=0.251      | 
|LOGISTIC REGRESSION|     P=0.026 *    (e)          (e)          P=0.171     |P=0.066      (e)          P=0.479      P=0.249      | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.070      (e)          P=0.500      P=0.247      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   8/50 (16%)   3/50 (6%)    7/50 (14%)  |16/50 (32%)  14/50 (28%)  13/50 (26%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     7/45.69      8/45.18      3/47.38      7/46.53     |16/46.04     14/46.40     13/47.33     8/48.38      | 
|POLY-3 PERCENT (g) |     15.3%        17.7%        6.3%         15.0%       |34.8%        30.2%        27.5%        16.5%        | 
|TERMINAL (d)       |     3/31 (10%)   7/38 (18%)   3/38 (8%)    7/40 (18%)  |15/39 (39%)  12/37 (32%)  12/39 (31%)  7/41 (17%)   | 
|FIRST INCIDENCE    |     639          668          729 (T)      729 (T)     |695          702          639          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.602      P=0.111N     P=0.454N    |P=0.024N*    P=0.476N     P=0.326N     P=0.037N*    | 
|POLY 3             |     P=0.438N     P=0.491      P=0.143N     P=0.599N    |P=0.024N*    P=0.402N     P=0.296N     P=0.034N*    | 
|POLY 1.5           |     P=0.445N     P=0.495      P=0.148N     P=0.604N    |P=0.028N*    P=0.405N     P=0.308N     P=0.039N*    | 
|POLY 6             |     P=0.431N     P=0.486      P=0.138N     P=0.594N    |P=0.020N*    P=0.404N     P=0.289N     P=0.030N*    | 
|LOGISTIC REGRESSION|     P=0.413N     P=0.502      P=0.154N     P=0.588N    |P=0.022N*    P=0.414N     P=0.305N     P=0.033N*    | 
|COCH-ARM / FISHERS |     P=0.457N     P=0.500      P=0.159N     P=0.613N    |P=0.037N*    P=0.414N     P=0.330N     P=0.050N     | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.85      2/44.95      1/47.41      0/46.53     |0/45.91      1/46.28      1/47.00      0/48.05      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.1%         0.0%        |0.0%         2.2%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    2/38 (5%)    0/38 (0%)    0/40 (0%)   |0/39 (0%)    1/37 (3%)    1/39 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      724          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.412N     P=0.284      P=0.543      (e)         |P=0.579N     P=0.489      P=0.500      (e)          | 
|POLY 3             |     P=0.447N     P=0.238      P=0.511      (e)         |P=0.582N     P=0.502      P=0.505      (e)          | 
|POLY 1.5           |     P=0.453N     P=0.238      P=0.507      (e)         |P=0.586N     P=0.501      P=0.503      (e)          | 
|POLY 6             |     P=0.438N     P=0.239      P=0.517      (e)         |P=0.578N     P=0.501      P=0.505      (e)          | 
|LOGISTIC REGRESSION|     P=0.431N     P=0.284      P=0.522      (e)         |(e)          P=0.489      P=0.500      (e)          | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.247      P=0.500      (e)         |P=0.595N     P=0.500      P=0.500      (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Prolapse                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/45.91      0/46.28      0/47.00      2/48.77      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         4.1%         | 
|TERMINAL (d)       |                                                        |0/39 (0%)    0/37 (0%)    0/39 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.051      (e)          (e)          P=0.256      | 
|POLY 3             |                                                        |P=0.048 *    (e)          (e)          P=0.251      | 
|POLY 1.5           |                                                        |P=0.047 *    (e)          (e)          P=0.246      | 
|POLY 6             |                                                        |P=0.049 *    (e)          (e)          P=0.257      | 
|LOGISTIC REGRESSION|                                                        |P=0.020 *    (e)          (e)          P=0.120      | 
|COCH-ARM / FISHERS |                                                        |P=0.046 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/04/01                           EXPERIMENT: 05205 TEST: 07                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                   P-NITROTOLUENE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         | 
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   10/50 (20%)  13/50 (26%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |                                                        |5/45.91      10/46.28     13/47.16     19/48.20     | 
|POLY-3 PERCENT (g) |                                                        |10.9%        21.6%        27.6%        39.4%        | 
|TERMINAL (d)       |                                                        |5/39 (13%)   10/37 (27%)  12/39 (31%)  17/41 (42%)  | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      687          690          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   P=0.104      P=0.032 *    P=0.002 **   | 
|POLY 3             |                                                        |P<0.001 **   P=0.132      P=0.036 *    P<0.001 **   | 
|POLY 1.5           |                                                        |P<0.001 **   P=0.132      P=0.035 *    P<0.001 **   | 
|POLY 6             |                                                        |P<0.001 **   P=0.131      P=0.036 *    P<0.001 **   | 
|LOGISTIC REGRESSION|                                                        |P<0.001 **   P=0.104      P=0.033 *    P=0.002 **   | 
|COCH-ARM / FISHERS |                                                        |P<0.001 **   P=0.131      P=0.033 *    P<0.001 **   | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    

--multipart-boundary
Content-type: text/plain
Range: bytes 397663-397663/397663


--multipart-boundary--