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TDMS Study 05205-08 Pathology Tables

NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                             P-NITROTOLUENE                                            DATE: 02/08/00    
EXPERIMENT: 05205 TEST: 08                                                                                        TIME: 09:15:45    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C62537D     
CONT: N01-ES-55393                                                                                                CAS: 99-99-0      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  




NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39

LAB: SOUTHERN RESEARCH INSTITUTE                      P-NITROTOLUENE                                              DATE: 02/08/00


EXPERIMENT: 05205 TEST: 08                                                                                        TIME:  9:47:25



TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  62537D

CONT: N01-ES-55393                                                                                                CAS: 99-99-0
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
                                               CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE

==================================================================================================================================
        0       PPM                 1250    PPM                        2500    PPM                        5000    PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                          DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  4     6.2    24.4       5.9     24.3    0.95      304      5.9     24.4    0.95      606      5.4     23.8    0.87     1139
  8     5.5    27.9       5.4     27.5    0.98      246      5.1     27.7    0.93      464      5.1     26.9    0.93      947
 12     5.6    31.6       5.6     31.3    1.00      222      5.5     31.5    0.98      433      5.2     30.3    0.93      866
 16     5.3    34.8       5.3     34.5    1.00      193      5.1     34.4    0.96      368      5.0     33.1    0.94      750
 20     5.3    37.7       5.6     37.5    1.06      188      5.7     37.3    1.08      380      5.4     35.8    1.02      757
 24     5.6    39.4       5.3     39.0    0.95      171      5.4     38.7    0.96      349      5.2     36.9    0.93      711
 28     5.1    40.8       4.9     40.7    0.96      152      4.9     40.1    0.96      306      4.8     39.0    0.94      614
 32     5.1    42.4       5.1     42.2    1.00      152      5.0     41.7    0.98      299      5.0     40.7    0.98      612
 36     4.7    43.0       5.0     43.1    1.06      144      4.9     42.1    1.04      292      4.9     41.3    1.04      590
 40     5.7    43.8       5.6     43.7    0.98      160      5.5     43.1    0.96      322      5.1     41.3    0.89      620
 44     5.3    44.7       5.1     44.9    0.96      142      5.1     44.0    0.96      293      5.0     41.9    0.94      597
 48     5.6    45.4       5.8     44.8    1.04      162      5.8     43.9    1.04      328      5.6     42.3    1.00      662
 52     6.1    45.2       6.0     44.7    0.98      169      6.0     43.4    0.98      345      5.8     42.1    0.95      684
 56     5.5    45.8       5.7     45.5    1.04      156      5.5     44.4    1.00      310      5.5     42.5    1.00      643
 60     5.6    45.8       5.7     45.9    1.02      156      5.8     44.0    1.04      327      5.6     42.1    1.00      670
 64     5.4    47.1       5.6     47.3    1.04      147      5.4     45.1    1.00      301      5.3     43.1    0.98      618
 68     5.3    47.4       5.5     47.7    1.04      145      5.5     45.6    1.04      304      5.1     43.1    0.96      592
 72     5.0    46.8       5.1     47.1    1.02      135      5.2     45.4    1.04      289      5.0     42.4    1.00      595
 76     5.7    45.5       5.8     46.6    1.02      154      5.9     44.5    1.04      333      5.5     42.5    0.96      647
 80     5.5    46.3       5.5     47.2    1.00      146      5.3     45.2    0.96      294      5.0     42.8    0.91      588
 84     5.2    46.7       5.4     47.5    1.04      142      5.3     45.4    1.02      291      5.1     42.4    0.98      606
 88     5.8    45.5       5.8     46.0    1.00      158      5.7     44.4    0.98      320      5.4     42.1    0.93      645
 92     5.6    45.1       5.9     45.4    1.05      161      5.8     43.9    1.04      331      5.4     42.0    0.96      641
 96     6.2    43.0       6.1     42.3    0.98      182      6.2     40.5    1.00      382      5.8     39.0    0.94      745
100     5.6    41.7       5.6     40.3    1.00      174      5.5     38.8    0.98      353      5.1     37.5    0.91      681
104     5.3    41.3       5.4     39.7    1.02      170      5.2     37.3    0.98      348      4.7     36.2    0.89      655

1 TO 13 WEEKS 
----------------
MEAN    5.7    27.9       5.6     27.7    0.98      257      5.5     27.9    0.95      501      5.3     27.0    0.91      984
SD(D)   0.4               0.2             0.02       42      0.4             0.03       92      0.2             0.03      140
CV(E)   7.0               4.4             2.5      16.4      7.1             2.9      18.4      3.1             3.6      14.3

14 TO 52 WEEKS
----------------
MEAN    5.4    41.7       5.4     41.5    1.00      163      5.3     40.9    0.99      328      5.2     39.5    0.96      660
SD(D)   0.4               0.4             0.04       17      0.4             0.04       31      0.3             0.05       63
CV(E)   7.2               6.9             4.1      10.5      7.3             4.2       9.6      6.3             4.7       9.5

> 52 WEEKS    
----------------
MEAN    5.5    45.2       5.6     45.3    1.02      156      5.6     43.4    1.01      322      5.3     41.4    0.96      640
SD(D)   0.3               0.3             0.02       13      0.3             0.03       28      0.3             0.04       43
CV(E)   5.6               4.5             2.0       8.6      5.3             2.6       8.6      5.5             4.0       6.8
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
                                               CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE

==================================================================================================================================
        0       PPM                 1250    PPM                        2500    PPM                        5000    PPM
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------
                                           DOSE/                              DOSE/                              DOSE/
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)
==================================================================================================================================
  4     3.5    18.1       3.9     19.2     1.11     257      4.0     19.3     1.14     520      3.7     18.4     1.06    1002
  8     3.8    21.7       3.9     22.4     1.03     216      3.9     22.2     1.03     435      3.7     20.9     0.97     883
 12     4.1    25.1       4.1     26.5     1.00     196      4.2     25.9     1.02     401      3.9     23.3     0.95     834
 16     4.1    28.2       4.0     28.2     0.98     179      4.2     27.9     1.02     372      3.8     24.7     0.93     768
 20     4.0    30.8       3.9     29.9     0.98     162      4.1     30.1     1.03     344      3.9     26.4     0.98     739
 24     4.1    32.2       4.4     32.8     1.07     166      4.1     33.0     1.00     314      3.7     28.2     0.90     659
 28     3.9    34.2       3.9     34.6     1.00     143      3.9     33.8     1.00     290      3.8     28.7     0.97     654
 32     4.1    34.7       4.0     36.4     0.98     137      3.7     34.8     0.90     266      3.8     29.7     0.93     631
 36     4.0    36.3       4.1     37.4     1.03     135      3.9     36.5     0.98     265      3.7     31.1     0.93     603
 40     4.4    36.2       4.3     38.0     0.98     143      4.4     37.2     1.00     296      3.9     31.6     0.89     621
 44     4.4    36.2       4.5     38.5     1.02     145      4.1     36.9     0.93     277      4.2     32.2     0.95     648
 48     5.1    38.9       5.0     40.8     0.98     153      4.7     39.7     0.92     298      4.3     33.6     0.84     637
 52     4.3    38.5       4.3     39.2     1.00     138      4.3     39.4     1.00     276      4.2     33.2     0.98     629
 56     4.5    38.4       4.4     39.7     0.98     139      4.4     39.5     0.98     280      4.1     33.5     0.91     607
 60     4.4    37.9       4.8     39.0     1.09     152      4.8     38.5     1.09     311      4.5     33.6     1.02     668
 64     4.2    39.0       4.4     41.2     1.05     135      4.2     40.0     1.00     260      3.8     34.9     0.90     539
 68     4.4    39.1       4.5     41.6     1.02     134      4.4     40.8     1.00     272      4.0     34.6     0.91     582
 72     4.0    38.9       4.3     40.7     1.08     132      4.2     40.2     1.05     263      3.9     33.8     0.98     580
 76     5.0    38.0       5.1     41.0     1.02     155      5.0     39.6     1.00     314      4.3     34.4     0.86     630
 80     4.6    39.2       4.4     42.0     0.96     131      4.5     41.3     0.98     271      3.9     35.1     0.85     561
 84     4.8    41.4       4.6     44.1     0.96     131      4.8     42.4     1.00     282      4.1     34.9     0.85     587
 88     4.6    39.3       4.9     41.5     1.07     147      5.1     40.0     1.11     317      4.5     34.6     0.98     651
 92     4.9    39.3       5.3     40.7     1.08     164      4.9     41.5     1.00     296      4.2     34.7     0.86     612
 96     4.2    39.2       4.3     40.4     1.02     134      4.4     39.1     1.05     284      4.1     33.7     0.98     607
100     4.7    38.9       4.7     39.3     1.00     150      5.0     40.2     1.06     312      4.1     34.7     0.87     587
104     4.5    38.5       4.6     39.1     1.02     148      4.2     38.9     0.93     270      3.7     32.9     0.82     557

1 TO 13 WEEKS 
----------------
MEAN    3.8    21.7       4.0     22.7     1.05     223      4.0     22.5     1.06     452      3.8     20.9     0.99     907
SD(D)   0.3               0.1              0.06      31      0.1              0.07      62      0.1              0.06      87
CV(E)   7.7               3.6              5.7     14.1      3.6              6.4     13.6      3.0              5.6      9.5

14 TO 52 WEEKS
----------------
MEAN    4.2    34.6       4.2     35.6     1.00     150      4.2     34.9     0.98     300      3.9     29.9     0.93     659
SD(D)   0.3               0.3              0.03      15      0.3              0.04      35      0.2              0.04      53
CV(E)   8.1               7.8              3.2      9.7      7.1              4.5     11.6      5.3              4.7      8.0

> 52 WEEKS    
----------------
MEAN    4.5    39.0       4.6     40.8     1.03     143      4.6     40.1     1.02     287      4.1     34.3     0.91     598
SD(D)   0.3               0.3              0.04      11      0.3              0.05      20      0.3              0.06      37
CV(E)   6.3               6.6              4.4      7.6      7.1              4.9      7.1      6.1              6.9      6.2
==================================================================================================================================

(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
                                 DIAGNOSTIC TRAILER REPORT
                                 FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
                                 CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE
=========================================================================================================
        0       PPM              1250    PPM              2500    PPM              5000    PPM
     ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
==========================================================================================================
  B               20.3  50                 20.2  50                 20.4  50                 20.3  50
  1               20.3  50                 20.2  50                 20.4  50                 20.3  50
  4   6.2  7871   24.4  50     5.9  7769   24.3  50     5.9  7938   24.4  50     5.4  7862   23.8  50
  8   5.5  8371   27.9  50     5.4  8301   27.5  50     5.1  8221   27.7  50     5.1  8200   26.9  50
 12   5.6  7785   31.6  50     5.6  7596   31.3  50     5.5  7666   31.5  50     5.2  7731   30.3  50
 16   5.3  8160   34.8  50     5.3  8237   34.5  50     5.1  8201   34.4  50     5.0  8124   33.1  50
 20   5.3  8155   37.7  50     5.6  8021   37.5  50     5.7  7920   37.3  50     5.4  7895   35.8  50
 24   5.6  8397   39.4  50     5.3  8370   39.0  50     5.4  8297   38.7  50     5.2  8265   36.9  50
 28   5.1  8340   40.8  50     4.9  8254   40.7  50     4.9  8186   40.1  50     4.8  8109   39.0  50
 32   5.1  8150   42.4  50     5.1  8105   42.2  50     5.0  7950   41.7  50     5.0  7753   40.7  50
 36   4.7  8405   43.0  50     5.0  8317   43.1  50     4.9  8265   42.1  50     4.9  8254   41.3  50
 40   5.7  8270   43.8  50     5.6  8209   43.7  50     5.5  8165   43.1  50     5.1  8131   41.3  50
 44   5.3  8285   44.7  50     5.1  8080   44.9  49     5.1  8179   44.0  50     5.0  8148   41.9  50
 48   5.6  8401   45.4  50     5.8  7999   44.8  49     5.8  8120   43.9  50     5.6  8105   42.3  50
 52   6.1  8280   45.2  50     6.0  7982   44.7  49     6.0  8110   43.4  50     5.8  8080   42.1  50
 56   5.5  8348   45.8  50     5.7  8129   45.5  49     5.5  8207   44.4  50     5.5  8190   42.5  50
 60   5.6  8059   45.8  50     5.7  7846   45.9  49     5.8  7533   44.0  50     5.6  7527   42.1  50
 64   5.4  8342   47.1  50     5.6  8107   47.3  49     5.4  8215   45.1  50     5.3  8111   43.1  50
 68   5.3  8227   47.4  49     5.5  8105   47.7  49     5.5  8249   45.6  50     5.1  8135   43.1  50
 72   5.0  8081   46.8  49     5.1  8104   47.1  49     5.2  8200   45.4  50     5.0  8100   42.4  50
 76   5.7  8104   45.5  49     5.8  7987   46.6  49     5.9  8115   44.5  50     5.5  7928   42.5  49
 80   5.5  8251   46.3  49     5.5  8232   47.2  49     5.3  8322   45.2  50     5.0  8114   42.8  49
 84   5.2  8227   46.7  49     5.4  8084   47.5  49     5.3  8226   45.4  50     5.1  7707   42.4  49
 88   5.8  8184   45.5  49     5.8  8217   46.0  49     5.7  8064   44.4  48     5.4  7860   42.1  47
 92   5.6  8112   45.1  49     5.9  8094   45.4  49     5.8  7793   43.9  47     5.4  7647   42.0  46
 96   6.2  7901   43.0  48     6.1  7843   42.3  49     6.2  7648   40.5  47     5.8  7460   39.0  46
100   5.6  7841   41.7  48     5.6  7834   40.3  48     5.5  7314   38.8  45     5.1  7137   37.5  44
104   5.3  7792   41.3  46     5.4  7769   39.7  46     5.2  7556   37.3  45     4.7  6987   36.2  42

MEAN BODY WGT FOR WEEKS
1 TO 13           26.0                     25.8                     26.0                     25.3
14 TO 52          41.7                     41.5                     40.9                     39.5
 > 52             45.2                     45.3                     43.4                     41.4
=========================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
                                 DIAGNOSTIC TRAILER REPORT
                                 FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
                                 CHRONIC DOSED FEED STUDY OF P-NITROTOLUENE
=========================================================================================================
        0       PPM              1250    PPM              2500    PPM              5000    PPM
     ----------------------   ----------------------   ----------------------   ----------------------
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS
==========================================================================================================
  B               15.5  50                 15.5  50                 16.6  50                 16.4  50
  1               15.5  50                 15.5  50                 16.6  50                 16.4  50
  4   3.5  8046   18.1  50     3.9  7996   19.2  50     4.0  8008   19.3  50     3.7  7922   18.4  50
  8   3.8  8293   21.7  50     3.9  8251   22.4  50     3.9  8159   22.2  50     3.7  8132   20.9  50
 12   4.1  8032   25.1  50     4.1  7890   26.5  50     4.2  7788   25.9  50     3.9  7750   23.3  50
 16   4.1  8250   28.2  50     4.0  8261   28.2  50     4.2  8250   27.9  50     3.8  8306   24.7  50
 20   4.0  8096   30.8  50     3.9  7965   29.9  50     4.1  7913   30.1  50     3.9  7807   26.4  50
 24   4.1  8435   32.2  50     4.4  8409   32.8  50     4.1  8333   33.0  50     3.7  8308   28.2  50
 28   3.9  8380   34.2  50     3.9  8349   34.6  50     3.9  8251   33.8  50     3.8  8222   28.7  50
 32   4.1  8081   34.7  50     4.0  7960   36.4  50     3.7  7840   34.8  50     3.8  7795   29.7  50
 36   4.0  8426   36.3  50     4.1  8397   37.4  50     3.9  8357   36.5  50     3.7  8256   31.1  50
 40   4.4  8323   36.2  50     4.3  8315   38.0  50     4.4  8193   37.2  50     3.9  8074   31.6  50
 44   4.4  8375   36.2  50     4.5  8276   38.5  50     4.1  8248   36.9  50     4.2  7987   32.2  49
 48   5.1  8371   38.9  50     5.0  8075   40.8  50     4.7  8130   39.7  50     4.3  7929   33.6  49
 52   4.3  8271   38.5  50     4.3  8252   39.2  50     4.3  8094   39.4  50     4.2  7905   33.2  49
 56   4.5  8420   38.4  50     4.4  8387   39.7  50     4.4  8350   39.5  50     4.1  8097   33.5  49
 60   4.4  7849   37.9  50     4.8  7954   39.0  50     4.8  7150   38.5  50     4.5  7374   33.6  49
 64   4.2  8364   39.0  50     4.4  8266   41.2  50     4.2  8245   40.0  50     3.8  7960   34.9  49
 68   4.4  8354   39.1  50     4.5  8252   41.6  50     4.4  8057   40.8  49     4.0  7959   34.6  49
 72   4.0  8295   38.9  50     4.3  8106   40.7  49     4.2  7977   40.2  49     3.9  7976   33.8  49
 76   5.0  8232   38.0  50     5.1  7954   41.0  49     5.0  7924   39.6  49     4.3  7887   34.4  49
 80   4.6  8386   39.2  50     4.4  8196   42.0  49     4.5  7961   41.3  48     3.9  8103   35.1  49
 84   4.8  8394   41.4  50     4.6  8150   44.1  49     4.8  7958   42.4  48     4.1  7990   34.9  49
 88   4.6  8397   39.3  50     4.9  8231   41.5  49     5.1  8090   40.0  48     4.5  8252   34.6  49
 92   4.9  8230   39.3  49     5.3  8135   40.7  49     4.9  7772   41.5  47     4.2  8083   34.7  49
 96   4.2  7709   39.2  48     4.3  7868   40.4  48     4.4  7556   39.1  47     4.1  7921   33.7  49
100   4.7  7269   38.9  47     4.7  7353   39.3  47     5.0  7276   40.2  45     4.1  7683   34.7  49
104   4.5  7739   38.5  46     4.6  7879   39.1  47     4.2  7178   38.9  43     3.7  8100   32.9  49

MEAN BODY WGT FOR WEEKS
1 TO 13           20.1                     20.9                     21.0                     19.7
14 TO 52          34.6                     35.6                     34.9                     29.9
 > 52             39.0                     40.8                     40.1                     34.3
=========================================================================================================

    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.

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