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TDMS Study 05205-08 Pathology Tables

NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00
Route: DOSED FEED                                                                                                 Time: 09:26:17

                                                 FINAL#1 CHRONIC STUDY FOR MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  99-99-0

       Lock Date:  08/24/98

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            1            5            1                                     
    Natural Death                                      2            2            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           47           41           49                                     
    Natural Death                                                                2                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (49)         (49)         (49)         (50)                                   
      Adenocarcinoma                                                                          1 (2%)                                
   Intestine Small, Jejunum                           (49)         (48)         (48)         (50)                                   
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                         3 (6%)       4 (8%)                    1 (2%)                                
      Hepatocellular Adenoma                           6 (12%)      3 (6%)       2 (4%)       4 (8%)                                
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Mesentery                                          (3)          (3)          (4)          (7)                                    
      Histiocytic Sarcoma                                                        1 (25%)                                            
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (25%)                                            
   Pancreas                                           (49)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                       3 (6%)       2 (4%)       1 (2%)                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Capsule, Sarcoma, Metastatic, Skeletal Muscle                              1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Pituitary Gland                                    (45)         (49)         (49)         (45)                                   
      Pars Distalis, Adenoma                                        1 (2%)       1 (2%)                                             
      Pars Intermedia, Carcinoma                                                 1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)         (50)         (50)         (49)                                   
      Cystadenoma                                      3 (6%)       1 (2%)       2 (4%)                                             
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                       1 (2%)                                                                       
      Luteoma                                                                    1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Leiomyoma                                                     1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                                                          1 (2%)                                
      Cervix, Hemangiosarcoma                                       1 (2%)                                                          
      Endometrium, Adenoma                                                       1 (2%)                                             
      Endometrium, Polyp Stromal                       3 (6%)       1 (2%)       4 (8%)       1 (2%)                                
      Endometrium, Sarcoma Stromal                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (2)          (5)          (13)         (4)                                    
      Fibrosarcoma, Metastatic, Skin                                             2 (15%)                                            
      Bronchial, Histiocytic Sarcoma                                             1 (8%)                                             
      Iliac, Histiocytic Sarcoma                                                 1 (8%)                                             
      Iliac, Sarcoma, Metastatic, Skeletal Muscle                                1 (8%)                                             
      Inguinal, Fibrosarcoma, Metastatic, Skin                                   1 (8%)                                             
      Inguinal, Histiocytic Sarcoma                                              1 (8%)                                             
      Mediastinal, Sarcoma, Metastatic, Skeletal                                                                                    
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
          Muscle                                                                 1 (8%)                                             
      Pancreatic, Histiocytic Sarcoma                                            1 (8%)                                             
      Renal, Histiocytic Sarcoma                                                 1 (8%)                                             
   Lymph Node, Mandibular                             (50)         (48)         (48)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (49)         (50)         (49)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (48)         (49)         (47)         (46)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                  1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    4 (8%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma NOS, Metastatic,                                                                                 
           Skin                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (3)          (1)                                    
      Sarcoma NOS, Metastatic, Skeletal Muscle                                   2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (4%)       2 (4%)       5 (10%)                               
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (4%)       3 (6%)                                
      Fibrosarcoma, Metastatic, Skin                                             2 (4%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
      Serosa, Sarcoma, Metastatic, Skeletal Muscle                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      External Ear, Melanoma Malignant                              1 (100%)                                                        
   Harderian Gland                                    (2)          (3)          (2)          (3)                                    
      Adenoma                                          2 (100%)     2 (67%)      1 (50%)      3 (100%)                              
      Carcinoma                                                     1 (33%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant                               3 (6%)       5 (10%)      9 (18%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   5                                                               
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            21          23          29          25                                       
     Total Primary Neoplasms                           32          28          41          27                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          14          14          14                                       
     Total Benign Neoplasms                            22          15          18          15                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               9          13          21          12                                       
     Total Malignant Neoplasms                         10          13          23          12                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      7           1                                       
     Total Metastatic Neoplasm                                                 18           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            2            3            6                                     
    Natural Death                                      2            2            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           46           45           42                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (48)         (48)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (49)         (49)         (49)                                   
      Polyp Adenomatous                                             2 (4%)                                                          
   Intestine Small, Jejunum                           (48)         (49)         (48)         (49)                                   
      Carcinoma                                                     1 (2%)                                                          
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Ileum                             (48)         (49)         (48)         (49)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Hepatoblastoma                                                                          1 (2%)                                
      Hepatocellular Carcinoma                         8 (16%)     11 (22%)     10 (20%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple                            1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma                          13 (26%)      9 (18%)     12 (24%)     11 (22%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       4 (8%)       3 (6%)       4 (8%)                                
      Hepatocholangiocarcinoma                         2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Ito Cell Tumor Malignant                                                   1 (2%)                                             
   Mesentery                                          (6)          (7)          (8)          (5)                                    
      Cholangiocarcinoma, Metastatic, Liver                         1 (14%)                                                         
      Hemangiosarcoma                                                            1 (13%)      1 (20%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (17%)                   1 (13%)                                            
      Histiocytic Sarcoma                              1 (17%)                                                                      
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)       2 (4%)       2 (4%)       3 (6%)                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)       1 (2%)                    1 (2%)                                
      Capsule, Adenoma                                 2 (4%)       3 (6%)       3 (6%)                                             
      Subcapsular, Adenoma                                                                    1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (46)         (49)         (49)         (45)                                   
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      Follicular Cell, Adenoma                                                                2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Prostate                                           (50)         (50)         (49)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
   Lymph Node                                         (5)          (5)          (3)          (5)                                    
      Renal, Hepatocholangiocarcinoma, Metastatic,                                                                                  
           Liver                                       1 (20%)                                                                      
   Lymph Node, Mandibular                             (48)         (50)         (45)         (48)                                   
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (49)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)                                   
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)       1 (2%)       1 (2%)                                
   Thymus                                             (47)         (40)         (44)         (45)                                   
      Histiocytic Sarcoma                              1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Cholangiocarcinoma, Metastatic, Liver                         1 (100%)                                                        
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      8 (16%)      6 (12%)     11 (22%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       5 (10%)      4 (8%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       1 (2%)                    2 (4%)                                
      Cholangiocarcinoma, Metastatic, Liver                         1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (6%)       1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mediastinum, Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                          
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
      Mediastinum, Histiocytic Sarcoma                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (4)          (6)          (2)                                    
      Adenoma                                          3 (100%)     3 (75%)      6 (100%)     1 (50%)                               
      Carcinoma                                                     1 (25%)                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Renal Tubule, Adenoma                                         1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       2 (4%)                                
      Lymphoma Malignant                               3 (6%)       3 (6%)       1 (2%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  10                                                               
NTP Experiment-Test: 05205-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           P-NITROTOLUENE                                      Date: 02/08/00  
Route: DOSED FEED                                                                                                 Time: 09:26:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            1250         2500         5000                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          38          41          44                                       
     Total Primary Neoplasms                           47          64          58          67                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          28          30          33                                       
     Total Benign Neoplasms                            29          38          35          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          24          20          21                                       
     Total Malignant Neoplasms                         18          26          23          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           5           2                                                   
     Total Metastatic Neoplasm                          3           8           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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