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TDMS Study 05205-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 02/08/00       
EXPERIMENT: 05205 TEST: 08                                                                                     TIME: 09:26:56       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 99-99-0         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                   FINAL#1 CHRONIC STUDY FOR MICE                                                   
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 02/08/00

EXPERIMENT: 05205 TEST: 08                                                                                     TIME: 09:26:56
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 99-99-0

Mice(B6C3F1)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
                                                 ---------------
                                                 Adrenal Cortex
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Ovary
                                                 Pituitary Gland
                                                 Spleen
                                                 Testes
                                                 Thyroid Gland
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 02/08/00     
EXPERIMENT: 05205 TEST: 08                                                                                     TIME: 09:26:56     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D     
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 99-99-0       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  P-NITROTOLUENE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Lung                                   Alveolar/Bronchiolar Adenoma
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Thyroid Gland: Follicular Cell         Adenoma
All Organs                             Benign Tumors
                                       Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Liver                                  Hepatocellular Carcinoma or Hepatocellular Adenoma
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs                             Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 1
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    3/49 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.3%         8.2%         6.3%         4.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     3/45 (7%)    4/46 (9%)    3/45 (7%)    2/42 (5%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.380N     P=0.512      P=0.663      P=0.531N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.352N     P=0.510      P=0.659      P=0.503N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.345N     P=0.509      P=0.661      P=0.497N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.362N     P=0.511      P=0.654      P=0.512N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.380N     P=0.512      P=0.663      P=0.531N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.337N     P=0.511      P=0.661N     P=0.490N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    6/50 (12%)   1/50 (2%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.2%         12.4%        2.1%        |4.1%         4.1%         2.1%         6.1%         |
|TERMINAL (d)       |     3/46 (7%)    3/46 (7%)    6/45 (13%)   1/42 (2%)   |2/46 (4%)    2/47 (4%)    1/43 (2%)    3/49 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.341N     P=0.663      P=0.232      P=0.338N    |P=0.426      P=0.687N     P=0.524N     P=0.529      |
|POLY 3             |     P=0.314N     P=0.660      P=0.238      P=0.315N    |P=0.403      P=0.692      P=0.510N     P=0.500      |
|POLY 1.5           |     P=0.305N     P=0.660      P=0.241      P=0.311N    |P=0.402      P=0.692      P=0.506N     P=0.497      |
|POLY 6             |     P=0.327N     P=0.662      P=0.232      P=0.322N    |P=0.407      P=0.693      P=0.513N     P=0.505      |
|LOGISTIC REGRESSION|     P=0.341N     P=0.663      P=0.232      P=0.338N    |P=0.426      P=0.687N     P=0.524N     P=0.529      |
|COCH-ARM / FISHERS |     P=0.297N     P=0.661N     P=0.243      P=0.309N    |P=0.404      P=0.691N     P=0.500N     P=0.500      |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 2
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    6/50 (12%)   2/50 (4%)   |2/50 (4%)    3/50 (6%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     6.1%         8.2%         12.4%        4.2%        |4.1%         6.1%         4.2%         6.1%         |
|TERMINAL (d)       |     3/46 (7%)    4/46 (9%)    6/45 (13%)   1/42 (2%)   |2/46 (4%)    3/47 (6%)    2/43 (5%)    3/49 (6%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      681         |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.464N     P=0.500      P=0.232      P=0.537N    |P=0.481      P=0.510      P=0.670      P=0.529      |
|POLY 3             |     P=0.428N     P=0.498      P=0.238      P=0.511N    |P=0.455      P=0.498      P=0.683      P=0.500      |
|POLY 1.5           |     P=0.419N     P=0.497      P=0.241      P=0.506N    |P=0.453      P=0.498      P=0.687      P=0.497      |
|POLY 6             |     P=0.440N     P=0.500      P=0.232      P=0.518N    |P=0.461      P=0.499      P=0.680      P=0.505      |
|LOGISTIC REGRESSION|     P=0.436N     P=0.500      P=0.232      P=0.502N    |P=0.481      P=0.510      P=0.670      P=0.529      |
|COCH-ARM / FISHERS |     P=0.410N     P=0.500      P=0.243      P=0.500N    |P=0.456      P=0.500      P=0.691N     P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Duodenum                                                                                                        |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.1%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    2/46 (4%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.424N     P=0.239      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.410N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.408N     P=0.236      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.413N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.239      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 3
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Site Unspecified                                                                                                |
|     Polyp Adenomatous                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.1%         0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    2/46 (4%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          689         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.517      P=0.239      (e)          P=0.487     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.531      P=0.237      (e)          P=0.495     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.534      P=0.236      (e)          P=0.497     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.525      P=0.237      (e)          P=0.492     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.541      P=0.239      (e)          P=0.509     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.539      P=0.247      (e)          P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  13/50 (26%)  15/50 (30%)  15/50 (30%) |6/49 (12%)   3/50 (6%)    2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     28.6%        26.7%        31.0%        31.5%       |12.3%        6.1%         4.2%         10.2%        |
|TERMINAL (d)       |     14/46 (30%)  13/46 (28%)  15/45 (33%)  15/42 (36%) |5/46 (11%)   3/47 (6%)    2/43 (5%)    5/49 (10%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |654          729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.285      P=0.500N     P=0.472      P=0.383     |P=0.471N     P=0.236N     P=0.158N     P=0.460N     |
|POLY 3             |     P=0.370      P=0.504N     P=0.487      P=0.465     |P=0.495N     P=0.242N     P=0.140N     P=0.495N     |
|POLY 1.5           |     P=0.388      P=0.506N     P=0.495      P=0.481     |P=0.495N     P=0.238N     P=0.135N     P=0.495N     |
|POLY 6             |     P=0.342      P=0.500N     P=0.473      P=0.441     |P=0.494N     P=0.245N     P=0.147N     P=0.493N     |
|LOGISTIC REGRESSION|     P=0.285      P=0.500N     P=0.472      P=0.383     |P=0.494N     P=0.221N     P=0.123N     P=0.484N     |
|COCH-ARM / FISHERS |     P=0.406      P=0.500N     P=0.500      P=0.500     |P=0.490N     P=0.233N     P=0.128N     P=0.486N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 4
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   12/50 (24%)  11/50 (22%)  12/50 (24%) |3/49 (6%)    4/50 (8%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     16.1%        24.6%        22.3%        24.7%       |6.2%         8.1%         0.0%         2.0%         |
|TERMINAL (d)       |     6/46 (13%)   12/46 (26%)  9/45 (20%)   9/42 (21%)  |3/46 (7%)    3/47 (6%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     453          729 (T)      597          585         |729 (T)      487          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.188      P=0.229      P=0.296      P=0.183     |P=0.107N     P=0.510      P=0.134N     P=0.283N     |
|POLY 3             |     P=0.233      P=0.213      P=0.298      P=0.209     |P=0.110N     P=0.512      P=0.122N     P=0.301N     |
|POLY 1.5           |     P=0.242      P=0.216      P=0.302      P=0.216     |P=0.109N     P=0.512      P=0.119N     P=0.302N     |
|POLY 6             |     P=0.222      P=0.212      P=0.293      P=0.200     |P=0.109N     P=0.513      P=0.124N     P=0.298N     |
|LOGISTIC REGRESSION|     P=0.268      P=0.232      P=0.337      P=0.271     |P=0.082N     P=0.628      (e)          P=0.283N     |
|COCH-ARM / FISHERS |     P=0.252      P=0.227      P=0.306      P=0.227     |P=0.108N     P=0.511      P=0.117N     P=0.301N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   12/50 (24%)  11/50 (22%)  13/50 (26%) |3/49 (6%)    4/50 (8%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     16.1%        24.6%        22.3%        26.8%       |6.2%         8.1%         0.0%         2.0%         |
|TERMINAL (d)       |     6/46 (13%)   12/46 (26%)  9/45 (20%)   9/42 (21%)  |3/46 (7%)    3/47 (6%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     453          729 (T)      597          585         |729 (T)      487          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.129      P=0.229      P=0.296      P=0.131     |P=0.107N     P=0.510      P=0.134N     P=0.283N     |
|POLY 3             |     P=0.163      P=0.213      P=0.298      P=0.148     |P=0.110N     P=0.512      P=0.122N     P=0.301N     |
|POLY 1.5           |     P=0.170      P=0.216      P=0.302      P=0.154     |P=0.109N     P=0.512      P=0.119N     P=0.302N     |
|POLY 6             |     P=0.155      P=0.212      P=0.293      P=0.141     |P=0.109N     P=0.513      P=0.124N     P=0.298N     |
|LOGISTIC REGRESSION|     P=0.191      P=0.232      P=0.337      P=0.198     |P=0.082N     P=0.628      (e)          P=0.283N     |
|COCH-ARM / FISHERS |     P=0.178      P=0.227      P=0.306      P=0.163     |P=0.108N     P=0.511      P=0.117N     P=0.301N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 5
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     20/50 (40%)  24/50 (48%)  25/50 (50%)  24/50 (48%) |8/49 (16%)   6/50 (12%)   2/50 (4%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     40.2%        49.2%        50.8%        49.5%       |16.4%        12.1%        4.2%         12.2%        |
|TERMINAL (d)       |     18/46 (39%)  24/46 (52%)  23/45 (51%)  21/42 (50%) |7/46 (15%)   5/47 (11%)   2/43 (5%)    6/49 (12%)   |
|FIRST INCIDENCE    |     453          729 (T)      597          585         |654          487          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.152      P=0.273      P=0.194      P=0.173     |P=0.273N     P=0.375N     P=0.061N     P=0.344N     |
|POLY 3             |     P=0.239      P=0.245      P=0.198      P=0.237     |P=0.296N     P=0.374N     P=0.049N*    P=0.382N     |
|POLY 1.5           |     P=0.256      P=0.251      P=0.204      P=0.252     |P=0.294N     P=0.373N     P=0.046N*    P=0.381N     |
|POLY 6             |     P=0.219      P=0.242      P=0.190      P=0.220     |P=0.296N     P=0.376N     P=0.052N     P=0.379N     |
|LOGISTIC REGRESSION|     P=0.265      P=0.269      P=0.218      P=0.282     |P=0.270N     P=0.289N     P=0.044N*    P=0.372N     |
|COCH-ARM / FISHERS |     P=0.275      P=0.273      P=0.211      P=0.273     |P=0.286N     P=0.371N     P=0.043N*    P=0.371N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     20/50 (40%)  24/50 (48%)  25/50 (50%)  25/50 (50%) |8/49 (16%)   6/50 (12%)   2/50 (4%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     40.2%        49.2%        50.8%        51.5%       |16.4%        12.1%        4.2%         12.2%        |
|TERMINAL (d)       |     18/46 (39%)  24/46 (52%)  23/45 (51%)  21/42 (50%) |7/46 (15%)   5/47 (11%)   2/43 (5%)    6/49 (12%)   |
|FIRST INCIDENCE    |     453          729 (T)      597          585         |654          487          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.108      P=0.273      P=0.194      P=0.131     |P=0.273N     P=0.375N     P=0.061N     P=0.344N     |
|POLY 3             |     P=0.178      P=0.245      P=0.198      P=0.179     |P=0.296N     P=0.374N     P=0.049N*    P=0.382N     |
|POLY 1.5           |     P=0.192      P=0.251      P=0.204      P=0.192     |P=0.294N     P=0.373N     P=0.046N*    P=0.381N     |
|POLY 6             |     P=0.162      P=0.242      P=0.190      P=0.165     |P=0.296N     P=0.376N     P=0.052N     P=0.379N     |
|LOGISTIC REGRESSION|     P=0.199      P=0.269      P=0.218      P=0.218     |P=0.270N     P=0.289N     P=0.044N*    P=0.372N     |
|COCH-ARM / FISHERS |     P=0.208      P=0.273      P=0.211      P=0.211     |P=0.286N     P=0.371N     P=0.043N*    P=0.371N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 6
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocholangiocarcinoma                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.1%         0.0%         2.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/46 (4%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          597          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199N     P=0.239N     P=0.503N     P=0.259N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.191N     P=0.238N     P=0.500N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.189N     P=0.238N     P=0.500N     P=0.241N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.193N     P=0.237N     P=0.502N     P=0.248N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.187N     (e)          P=0.531N     (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   9/50 (18%)   8/50 (16%)   13/50 (26%) |5/50 (10%)   2/50 (4%)    2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     12.2%        18.5%        16.5%        26.8%       |10.2%        4.1%         4.2%         10.2%        |
|TERMINAL (d)       |     4/46 (9%)    9/46 (20%)   7/45 (16%)   11/42 (26%) |5/46 (11%)   2/47 (4%)    1/43 (2%)    5/49 (10%)   |
|FIRST INCIDENCE    |     665          729 (T)      693          505         |729 (T)      729 (T)      714          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.034 *    P=0.290      P=0.369      P=0.048 *   |P=0.493      P=0.209N     P=0.244N     P=0.590N     |
|POLY 3             |     P=0.049 *    P=0.282      P=0.377      P=0.057     |P=0.461      P=0.219N     P=0.228N     P=0.629      |
|POLY 1.5           |     P=0.051      P=0.283      P=0.383      P=0.059     |P=0.460      P=0.219N     P=0.224N     P=0.626      |
|POLY 6             |     P=0.044 *    P=0.281      P=0.367      P=0.052     |P=0.466      P=0.218N     P=0.231N     P=0.622N     |
|LOGISTIC REGRESSION|     P=0.053      P=0.285      P=0.387      P=0.070     |P=0.477      P=0.209N     P=0.233N     P=0.590N     |
|COCH-ARM / FISHERS |     P=0.053      P=0.288      P=0.387      P=0.062     |P=0.463      P=0.218N     P=0.218N     P=0.630N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 7
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   4/50 (8%)    6/50 (12%)  |1/50 (2%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     4.1%         12.2%        8.3%         12.3%       |2.0%         0.0%         4.2%         6.1%         |
|TERMINAL (d)       |     2/46 (4%)    4/46 (9%)    4/45 (9%)    3/42 (7%)   |1/46 (2%)    0/47 (0%)    2/43 (5%)    3/49 (6%)    |
|FIRST INCIDENCE    |     729 (T)      689          729 (T)      585         |729 (T)      ---          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.148      P=0.140      P=0.327      P=0.119     |P=0.117      P=0.496N     P=0.476      P=0.328      |
|POLY 3             |     P=0.176      P=0.134      P=0.333      P=0.132     |P=0.104      P=0.501N     P=0.490      P=0.305      |
|POLY 1.5           |     P=0.178      P=0.133      P=0.336      P=0.133     |P=0.103      P=0.501N     P=0.494      P=0.304      |
|POLY 6             |     P=0.171      P=0.137      P=0.328      P=0.129     |P=0.106      P=0.500N     P=0.487      P=0.310      |
|LOGISTIC REGRESSION|     P=0.186      P=0.134      P=0.327      P=0.150     |P=0.117      (e)          P=0.476      P=0.328      |
|COCH-ARM / FISHERS |     P=0.179      P=0.134      P=0.339      P=0.134     |P=0.104      P=0.500N     P=0.500      P=0.309      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   14/50 (28%)  12/50 (24%)  19/50 (38%) |6/50 (12%)   2/50 (4%)    4/50 (8%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     16.3%        28.6%        24.7%        38.4%       |12.2%        4.1%         8.4%         16.3%        |
|TERMINAL (d)       |     6/46 (13%)   12/46 (26%)  11/45 (24%)  14/42 (33%) |6/46 (13%)   2/47 (4%)    3/43 (7%)    8/49 (16%)   |
|FIRST INCIDENCE    |     665          689          693          505         |729 (T)      729 (T)      714          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   P=0.123      P=0.214      P=0.010 *   |P=0.198      P=0.128N     P=0.410N     P=0.436      |
|POLY 3             |     P=0.014 *    P=0.111      P=0.217      P=0.011 *   |P=0.168      P=0.135N     P=0.387N     P=0.387      |
|POLY 1.5           |     P=0.014 *    P=0.110      P=0.223      P=0.011 *   |P=0.167      P=0.135N     P=0.381N     P=0.383      |
|POLY 6             |     P=0.013 *    P=0.112      P=0.207      P=0.010 *   |P=0.172      P=0.134N     P=0.392N     P=0.396      |
|LOGISTIC REGRESSION|     P=0.015 *    P=0.112      P=0.222      P=0.016 *   |P=0.185      P=0.128N     P=0.397N     P=0.436      |
|COCH-ARM / FISHERS |     P=0.014 *    P=0.114      P=0.227      P=0.012 *   |P=0.169      P=0.134N     P=0.370N     P=0.387      |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 8
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/48 (6%)    1/50 (2%)    2/50 (4%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.3%         2.0%         4.2%         0.0%         |
|TERMINAL (d)       |                                                        |3/45 (7%)    1/47 (2%)    2/43 (5%)    0/48 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.099N     P=0.290N     P=0.521N     P=0.110N     |
|POLY 3             |                                                        |P=0.101N     P=0.295N     P=0.497N     P=0.117N     |
|POLY 1.5           |                                                        |P=0.102N     P=0.294N     P=0.491N     P=0.117N     |
|POLY 6             |                                                        |P=0.100N     P=0.296N     P=0.504N     P=0.115N     |
|LOGISTIC REGRESSION|                                                        |P=0.099N     P=0.290N     P=0.521N     (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.100N     P=0.293N     P=0.480N     P=0.117N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.0%         0.0%         0.0%        |4.1%         0.0%         8.1%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |1/46 (2%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          280          ---          ---         |682          ---          456          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.567N     P=0.500      (e)          (e)         |P=0.336N     P=0.240N     P=0.327      P=0.231N     |
|POLY 3             |     P=0.567N     P=0.503      (e)          (e)         |P=0.336N     P=0.239N     P=0.340      P=0.238N     |
|POLY 1.5           |     P=0.567N     P=0.502      (e)          (e)         |P=0.338N     P=0.239N     P=0.339      P=0.239N     |
|POLY 6             |     P=0.568N     P=0.504      (e)          (e)         |P=0.331N     P=0.239N     P=0.342      P=0.236N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.160N     P=0.212N     P=0.684      P=0.222N     |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.337N     P=0.247N     P=0.339      P=0.247N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 9
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.0%         0.0%         0.0%        |2.0%         0.0%         8.1%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          280          ---          ---         |682          ---          456          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.567N     P=0.500      (e)          (e)         |P=0.528N     P=0.504N     P=0.178      P=0.496N     |
|POLY 3             |     P=0.567N     P=0.503      (e)          (e)         |P=0.532N     P=0.502N     P=0.181      P=0.501N     |
|POLY 1.5           |     P=0.567N     P=0.502      (e)          (e)         |P=0.534N     P=0.501N     P=0.180      P=0.502N     |
|POLY 6             |     P=0.568N     P=0.504      (e)          (e)         |P=0.526N     P=0.502N     P=0.182      P=0.499N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.301N     P=0.444N     P=0.472      P=0.470N     |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.531N     P=0.500N     P=0.181      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.0%         0.0%         0.0%        |4.1%         0.0%         8.1%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |1/46 (2%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          280          ---          ---         |682          ---          456          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.567N     P=0.500      (e)          (e)         |P=0.336N     P=0.240N     P=0.327      P=0.231N     |
|POLY 3             |     P=0.567N     P=0.503      (e)          (e)         |P=0.336N     P=0.239N     P=0.340      P=0.238N     |
|POLY 1.5           |     P=0.567N     P=0.502      (e)          (e)         |P=0.338N     P=0.239N     P=0.339      P=0.239N     |
|POLY 6             |     P=0.568N     P=0.504      (e)          (e)         |P=0.331N     P=0.239N     P=0.342      P=0.236N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.160N     P=0.212N     P=0.684      P=0.222N     |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.337N     P=0.247N     P=0.339      P=0.247N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 10
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    3/50 (6%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.0%         4.1%         4.1%         6.2%        |0.0%         6.1%         4.2%         2.0%         |
|TERMINAL (d)       |     1/46 (2%)    2/46 (4%)    2/45 (4%)    1/42 (2%)   |0/46 (0%)    3/47 (6%)    1/43 (2%)    1/49 (2%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      625         |---          729 (T)      682          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.206      P=0.500      P=0.492      P=0.285     |P=0.571      P=0.125      P=0.228      P=0.513      |
|POLY 3             |     P=0.228      P=0.499      P=0.497      P=0.300     |P=0.555      P=0.118      P=0.232      P=0.500      |
|POLY 1.5           |     P=0.231      P=0.498      P=0.499      P=0.303     |P=0.552      P=0.118      P=0.234      P=0.499      |
|POLY 6             |     P=0.223      P=0.500      P=0.493      P=0.296     |P=0.562      P=0.119      P=0.231      P=0.502      |
|LOGISTIC REGRESSION|     P=0.237      P=0.500      P=0.492      P=0.322     |P=0.555      P=0.125      P=0.254      P=0.513      |
|COCH-ARM / FISHERS |     P=0.232      P=0.500      P=0.500      P=0.309     |P=0.556      P=0.121      P=0.247      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    2/49 (4%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.3%        |0.0%         2.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/44 (0%)    2/41 (5%)   |0/46 (0%)    1/47 (2%)    0/42 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.039 *    (e)          (e)          P=0.214     |P=0.559N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.227     |P=0.570N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.230     |P=0.569N     P=0.499      (e)          (e)          |
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.222     |P=0.569N     P=0.500      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.214     |(e)          P=0.504      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 11
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.1%         2.0%         8.4%         2.0%         |
|TERMINAL (d)       |                                                        |3/46 (7%)    1/47 (2%)    4/43 (9%)    1/49 (2%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.325N     P=0.298N     P=0.463      P=0.283N     |
|POLY 3             |                                                        |P=0.343N     P=0.307N     P=0.485      P=0.306N     |
|POLY 1.5           |                                                        |P=0.346N     P=0.307N     P=0.490      P=0.308N     |
|POLY 6             |                                                        |P=0.338N     P=0.306N     P=0.480      P=0.302N     |
|LOGISTIC REGRESSION|                                                        |P=0.325N     P=0.298N     P=0.463      P=0.283N     |
|COCH-ARM / FISHERS |                                                        |P=0.343N     P=0.309N     P=0.500      P=0.309N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |3/50 (6%)    1/50 (2%)    4/50 (8%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |6.1%         2.0%         8.4%         2.0%         |
|TERMINAL (d)       |                                                        |3/46 (7%)    1/47 (2%)    4/43 (9%)    1/49 (2%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.325N     P=0.298N     P=0.463      P=0.283N     |
|POLY 3             |                                                        |P=0.343N     P=0.307N     P=0.485      P=0.306N     |
|POLY 1.5           |                                                        |P=0.346N     P=0.307N     P=0.490      P=0.308N     |
|POLY 6             |                                                        |P=0.338N     P=0.306N     P=0.480      P=0.302N     |
|LOGISTIC REGRESSION|                                                        |P=0.325N     P=0.298N     P=0.463      P=0.283N     |
|COCH-ARM / FISHERS |                                                        |P=0.343N     P=0.309N     P=0.500      P=0.309N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 12
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.1%         0.0%         0.0%        |2.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    1/46 (2%)    0/45 (0%)    0/42 (0%)   |1/46 (2%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          689          ---          ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.422N     P=0.242      (e)          (e)         |P=0.302N     P=0.496N     P=0.513N     P=0.487N     |
|POLY 3             |     P=0.410N     P=0.237      (e)          (e)         |P=0.307N     P=0.501N     P=0.506N     P=0.500N     |
|POLY 1.5           |     P=0.408N     P=0.237      (e)          (e)         |P=0.306N     P=0.501N     P=0.504N     P=0.501N     |
|POLY 6             |     P=0.413N     P=0.239      (e)          (e)         |P=0.309N     P=0.500N     P=0.507N     P=0.498N     |
|LOGISTIC REGRESSION|     P=0.403N     P=0.241      (e)          (e)         |P=0.302N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.0%         2.1%         6.2%         4.2%        |2.0%         2.0%         0.0%         2.0%         |
|TERMINAL (d)       |     1/46 (2%)    1/46 (2%)    2/45 (4%)    2/42 (5%)   |0/46 (0%)    1/47 (2%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      689          729 (T)     |707          729 (T)      ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.291      P=0.761      P=0.299      P=0.468     |P=0.602N     P=0.758N     P=0.509N     P=0.749N     |
|POLY 3             |     P=0.312      P=0.760      P=0.303      P=0.490     |P=0.617N     P=0.759      P=0.506N     P=0.760      |
|POLY 1.5           |     P=0.319      P=0.759      P=0.305      P=0.495     |P=0.617N     P=0.759      P=0.504N     P=0.759      |
|POLY 6             |     P=0.302      P=0.760      P=0.300      P=0.484     |P=0.617N     P=0.759      P=0.508N     P=0.759N     |
|LOGISTIC REGRESSION|     P=0.316      P=0.761      P=0.305      P=0.468     |P=0.617N     P=0.759N     P=0.482N     P=0.761N     |
|COCH-ARM / FISHERS |     P=0.324      P=0.753N     P=0.309      P=0.500     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 13
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.0%         6.1%         6.2%         4.2%        |4.1%         2.0%         0.0%         2.0%         |
|TERMINAL (d)       |     1/46 (2%)    2/46 (4%)    2/45 (4%)    2/42 (5%)   |1/46 (2%)    1/47 (2%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     729 (T)      689          689          729 (T)     |707          729 (T)      ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.436      P=0.309      P=0.299      P=0.468     |P=0.356N     P=0.495N     P=0.252N     P=0.481N     |
|POLY 3             |     P=0.460      P=0.306      P=0.303      P=0.490     |P=0.369N     P=0.502N     P=0.244N     P=0.501N     |
|POLY 1.5           |     P=0.468      P=0.305      P=0.305      P=0.495     |P=0.368N     P=0.502N     P=0.242N     P=0.502N     |
|POLY 6             |     P=0.447      P=0.308      P=0.300      P=0.484     |P=0.369N     P=0.502N     P=0.247N     P=0.497N     |
|LOGISTIC REGRESSION|     P=0.475      P=0.305      P=0.305      P=0.468     |P=0.368N     P=0.498N     P=0.233N     P=0.500N     |
|COCH-ARM / FISHERS |     P=0.477      P=0.309      P=0.309      P=0.500     |P=0.366N     P=0.500N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         0.0%         2.1%         4.2%        |0.0%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    0/46 (0%)    0/45 (0%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    1/43 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          693          681         |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228      P=0.500N     P=0.753      P=0.474     |P=0.698      (e)          P=0.487      (e)          |
|POLY 3             |     P=0.243      P=0.501N     P=0.759      P=0.492     |P=0.696      (e)          P=0.494      (e)          |
|POLY 1.5           |     P=0.246      P=0.501N     P=0.760      P=0.496     |P=0.693      (e)          P=0.496      (e)          |
|POLY 6             |     P=0.239      P=0.500N     P=0.757      P=0.486     |P=0.701      (e)          P=0.493      (e)          |
|LOGISTIC REGRESSION|     P=0.251      (e)          P=0.762      P=0.506     |(e)          (e)          P=0.487      (e)          |
|COCH-ARM / FISHERS |     P=0.247      P=0.500N     P=0.753N     P=0.500     |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 14
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    1/50 (2%)    4/50 (8%)   |3/50 (6%)    5/50 (10%)   9/50 (18%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     6.1%         6.2%         2.1%         8.4%        |6.1%         10.2%        18.8%        10.2%        |
|TERMINAL (d)       |     3/46 (7%)    3/46 (7%)    1/45 (2%)    3/42 (7%)   |2/46 (4%)    4/47 (9%)    9/43 (21%)   5/49 (10%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      681         |707          680          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392      P=0.663      P=0.313N     P=0.455     |P=0.333      P=0.368      P=0.050      P=0.391      |
|POLY 3             |     P=0.428      P=0.660      P=0.309N     P=0.487     |P=0.294      P=0.356      P=0.053      P=0.356      |
|POLY 1.5           |     P=0.433      P=0.660      P=0.307N     P=0.493     |P=0.291      P=0.356      P=0.056      P=0.354      |
|POLY 6             |     P=0.420      P=0.662      P=0.313N     P=0.479     |P=0.302      P=0.358      P=0.051      P=0.362      |
|LOGISTIC REGRESSION|     P=0.421      P=0.663      P=0.313N     P=0.489     |P=0.298      P=0.361      P=0.052      P=0.356      |
|COCH-ARM / FISHERS |     P=0.438      P=0.661N     P=0.309N     P=0.500     |P=0.296      P=0.357      P=0.061      P=0.357      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  28/50 (56%)  30/50 (60%)  33/50 (66%) |17/50 (34%)  14/50 (28%)  14/50 (28%)  14/50 (28%)  |
|POLY-3 ADJUSTED (b)|     50.8%        57.2%        61.8%        67.4%       |34.4%        28.7%        29.2%        28.5%        |
|TERMINAL (d)       |     23/46 (50%)  27/46 (59%)  29/45 (64%)  29/42 (69%) |16/46 (35%)  14/47 (30%)  12/43 (28%)  14/49 (29%)  |
|FIRST INCIDENCE    |     665          689          693          505         |654          729 (T)      682          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.018 *    P=0.347      P=0.179      P=0.035 *   |P=0.274N     P=0.308N     P=0.416N     P=0.264N     |
|POLY 3             |     P=0.054      P=0.332      P=0.186      P=0.069     |P=0.336N     P=0.346N     P=0.368N     P=0.341N     |
|POLY 1.5           |     P=0.058      P=0.332      P=0.200      P=0.074     |P=0.338N     P=0.342N     P=0.355N     P=0.344N     |
|POLY 6             |     P=0.046 *    P=0.334      P=0.165      P=0.062     |P=0.326N     P=0.348N     P=0.379N     P=0.331N     |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.339      P=0.165      P=0.069     |P=0.319N     P=0.336N     P=0.371N     P=0.333N     |
|COCH-ARM / FISHERS |     P=0.061      P=0.344      P=0.211      P=0.078     |P=0.328N     P=0.333N     P=0.333N     P=0.333N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 15
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/50 (28%)  24/50 (48%)  20/50 (40%)  21/50 (42%) |9/50 (18%)   13/50 (26%)  23/50 (46%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     28.2%        48.0%        40.0%        42.7%       |18.2%        26.1%        46.1%        24.5%        |
|TERMINAL (d)       |     12/46 (26%)  20/46 (44%)  15/45 (33%)  15/42 (36%) |7/46 (15%)   11/47 (23%)  17/43 (40%)  12/49 (25%)  |
|FIRST INCIDENCE    |     453          280          597          585         |682          487          456          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.131      P=0.042 *    P=0.148      P=0.076     |P=0.315      P=0.257      P=0.003 **   P=0.371      |
|POLY 3             |     P=0.181      P=0.032 *    P=0.151      P=0.096     |P=0.238      P=0.242      P=0.002 **   P=0.307      |
|POLY 1.5           |     P=0.186      P=0.031 *    P=0.148      P=0.099     |P=0.237      P=0.239      P=0.002 **   P=0.305      |
|POLY 6             |     P=0.177      P=0.033 *    P=0.154      P=0.094     |P=0.248      P=0.246      P=0.002 **   P=0.314      |
|LOGISTIC REGRESSION|     P=0.288      P=0.029 *    P=0.201      P=0.134     |P=0.273      P=0.253      P=0.005 **   P=0.309      |
|COCH-ARM / FISHERS |     P=0.196      P=0.032 *    P=0.146      P=0.104     |P=0.254      P=0.235      P=0.002 **   P=0.312      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     31/50 (62%)  38/50 (76%)  41/50 (82%)  44/50 (88%) |21/50 (42%)  23/50 (46%)  31/50 (62%)  25/50 (50%)  |
|POLY-3 ADJUSTED (b)|     62.0%        76.0%        82.0%        88.0%       |42.3%        46.2%        62.0%        51.0%        |
|TERMINAL (d)       |     27/46 (59%)  34/46 (74%)  36/45 (80%)  36/42 (86%) |18/46 (39%)  21/47 (45%)  24/43 (56%)  25/49 (51%)  |
|FIRST INCIDENCE    |     453          280          597          505         |654          487          456          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.130      P=0.034 *    P=0.003 **  |P=0.288      P=0.455      P=0.032 *    P=0.378      |
|POLY 3             |     P=0.002 **   P=0.097      P=0.021 *    P=0.002 **  |P=0.174      P=0.425      P=0.037 *    P=0.256      |
|POLY 1.5           |     P=0.002 **   P=0.097      P=0.021 *    P=0.002 **  |P=0.175      P=0.423      P=0.036 *    P=0.256      |
|POLY 6             |     P=0.002 **   P=0.097      P=0.021 *    P=0.002 **  |P=0.180      P=0.426      P=0.039 *    P=0.261      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.202      P=0.431      P=0.051      P=0.266      |
|COCH-ARM / FISHERS |     P=0.002 **   P=0.097      P=0.022 *    P=0.002 **  |P=0.195      P=0.420      P=0.036 *    P=0.274      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).

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