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TDMS Study 05205-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 02/08/00       
EXPERIMENT: 05205 TEST: 08                                                                                     TIME: 09:33:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D       
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 99-99-0         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                   FINAL#1 CHRONIC STUDY FOR MICE                                                   
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Southern Research Inst                                  P-NITROTOLUENE                                    DATE: 02/08/00     
EXPERIMENT: 05205 TEST: 08                                                                                     TIME: 09:33:52     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: N01-ES-55393                              ROUTE: DOSED FEED                                              NTP C#: 62537D     
PATHOLOGIST: FARNELL, D.                                                                                       CAS: 99-99-0       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  P-NITROTOLUENE
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Cytoplasmic Alteration Focal
Intestine Small, Ileum: Peyer's Patch  Hyperplasia Lymphoid
Intestine Small, Jejunum: Peyer's Patch
                                       Hyperplasia Lymphoid
Liver                                  Basophilic Focus
Liver: Hepatocyte                      Syncytial Alteration Focal
Lung                                   Hemorrhage
                                       Infiltration Cellular Mixed Cell
Lung: Alveolar Epithelium              Bronchiolization
                                       Hyperplasia
Parathyroid Gland                      Cyst
Testes: Germinal Epithelium            Degeneration
Thyroid Gland                          Degeneration Cystic Focal
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Kidney                                 Nephropathy
Liver: Hepatocyte, Centrilobular       Vacuolization Cytoplasmic
Lung: Alveolar Epithelium              Bronchiolization
Lymph Node, Mesenteric                 Hyperplasia Lymphoid
Spleen                                 Hematopoietic Cell Proliferation
Stomach, Forestomach                   Diverticulum
Thyroid Gland                          Degeneration Cystic Focal
===============================================================
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.1%         0.0%         0.0%        |0.0%         2.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/45 (0%)    2/46 (4%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    1/47 (2%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.420N     P=0.243      (e)          (e)         |P=0.559N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.407N     P=0.241      (e)          (e)         |P=0.569N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.405N     P=0.241      (e)          (e)         |P=0.569N     P=0.499      (e)          (e)          |
|POLY 6             |     P=0.410N     P=0.242      (e)          (e)         |P=0.569N     P=0.500      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.243      (e)          (e)         |(e)          P=0.504      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.402N     P=0.253      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Cytoplasmic Alteration Focal                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    5/50 (10%)   9/49 (18%)   2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.1%         10.3%        18.9%        4.2%        |0.0%         2.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/45 (0%)    5/46 (11%)   9/45 (20%)   2/42 (5%)   |0/46 (0%)    1/47 (2%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     717          729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.432      P=0.109      P=0.010 *    P=0.471     |P=0.559N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.461      P=0.106      P=0.008 **   P=0.497     |P=0.569N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.476      P=0.106      P=0.008 **   P=0.502     |P=0.569N     P=0.499      (e)          (e)          |
|POLY 6             |     P=0.439      P=0.106      P=0.007 **   P=0.490     |P=0.569N     P=0.500      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.439      P=0.107      P=0.009 **   P=0.493     |(e)          P=0.504      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.492      P=0.107      P=0.008 **   P=0.508     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    0/50 (0%)    0/49 (0%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.3%         0.0%         0.0%         8.4%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/45 (9%)    0/46 (0%)    0/45 (0%)    4/42 (10%)  |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.370      P=0.061N     P=0.064N     P=0.605     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.404      P=0.058N     P=0.061N     P=0.639     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.407      P=0.059N     P=0.061N     P=0.639N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.400      P=0.058N     P=0.063N     P=0.629     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.370      (e)          (e)          P=0.605     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.409      P=0.056N     P=0.059N     P=0.631N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Capsule                                                                                                          |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    6/50 (12%)   1/49 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.1%         12.3%        2.1%         2.1%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/45 (2%)    6/46 (13%)   1/45 (2%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.290N     P=0.062      P=0.761      P=0.746     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.267N     P=0.059      P=0.759      P=0.759     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.262N     P=0.059      P=0.760      P=0.759N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.275N     P=0.060      P=0.757      P=0.755     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.290N     P=0.062      P=0.761      P=0.746     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.258N     P=0.059      P=0.753N     P=0.747N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/45 (0%)    2/49 (4%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.0%         0.0%         4.2%         0.0%         |
|TERMINAL (d)       |                                                        |1/46 (2%)    0/42 (0%)    1/42 (2%)    0/47 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      ---          625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.456N     P=0.518N     P=0.474      P=0.496N     |
|POLY 3             |                                                        |P=0.463N     P=0.522N     P=0.486      P=0.508N     |
|POLY 1.5           |                                                        |P=0.465N     P=0.522N     P=0.488      P=0.509N     |
|POLY 6             |                                                        |P=0.459N     P=0.522N     P=0.484      P=0.506N     |
|LOGISTIC REGRESSION|                                                        |P=0.429N     (e)          P=0.561      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.463N     P=0.526N     P=0.492      P=0.510N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    4/45 (9%)    3/49 (6%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.0%         9.1%         6.4%         4.3%         |
|TERMINAL (d)       |                                                        |1/46 (2%)    4/42 (10%)   3/42 (7%)    2/47 (4%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.563      P=0.154      P=0.274      P=0.508      |
|POLY 3             |                                                        |P=0.537      P=0.146      P=0.288      P=0.485      |
|POLY 1.5           |                                                        |P=0.534      P=0.147      P=0.292      P=0.484      |
|POLY 6             |                                                        |P=0.545      P=0.146      P=0.285      P=0.490      |
|LOGISTIC REGRESSION|                                                        |P=0.563      P=0.154      P=0.274      P=0.508      |
|COCH-ARM / FISHERS |                                                        |P=0.539      P=0.150      P=0.301      P=0.485      |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    3/50 (6%)   |4/50 (8%)    2/50 (4%)    1/50 (2%)    6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     4.1%         2.1%         6.2%         6.3%        |8.1%         4.1%         2.1%         12.2%        |
|TERMINAL (d)       |     2/46 (4%)    1/46 (2%)    3/45 (7%)    2/42 (5%)   |4/46 (9%)    2/47 (4%)    1/43 (2%)    6/49 (12%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      681         |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.266      P=0.500N     P=0.490      P=0.463     |P=0.229      P=0.327N     P=0.201N     P=0.410      |
|POLY 3             |     P=0.293      P=0.501N     P=0.495      P=0.489     |P=0.203      P=0.340N     P=0.188N     P=0.370      |
|POLY 1.5           |     P=0.298      P=0.502N     P=0.498      P=0.494     |P=0.202      P=0.340N     P=0.185N     P=0.367      |
|POLY 6             |     P=0.285      P=0.500N     P=0.490      P=0.482     |P=0.205      P=0.339N     P=0.191N     P=0.377      |
|LOGISTIC REGRESSION|     P=0.291      P=0.500N     P=0.490      P=0.498     |P=0.229      P=0.327N     P=0.201N     P=0.410      |
|COCH-ARM / FISHERS |     P=0.302      P=0.500N     P=0.500      P=0.500     |P=0.205      P=0.339N     P=0.181N     P=0.370      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Inflammation Chronic Focal                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.1%         2.0%         0.0%         0.0%        |2.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |1/46 (2%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     665          689          ---          ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.109N     P=0.498N     P=0.247N     P=0.257N    |P=0.302N     P=0.496N     P=0.513N     P=0.487N     |
|POLY 3             |     P=0.102N     P=0.502N     P=0.241N     P=0.245N    |P=0.307N     P=0.501N     P=0.506N     P=0.500N     |
|POLY 1.5           |     P=0.101N     P=0.502N     P=0.239N     P=0.241N    |P=0.306N     P=0.501N     P=0.504N     P=0.501N     |
|POLY 6             |     P=0.103N     P=0.501N     P=0.244N     P=0.250N    |P=0.309N     P=0.500N     P=0.507N     P=0.498N     |
|LOGISTIC REGRESSION|     P=0.099N     P=0.481N     P=0.245N     P=0.227N    |P=0.302N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Epicardium                                                                                                                |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |2/46 (4%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.234N     P=0.253N     P=0.225N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.238N     P=0.244N     P=0.238N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.238N     P=0.241N     P=0.239N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.238N     P=0.246N     P=0.235N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.114N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Ileum: Peyer's Patch                                                                                            |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/48 (0%)    3/49 (6%)   |2/49 (4%)    0/48 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         6.4%        |4.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    3/42 (7%)   |2/46 (4%)    0/47 (0%)    0/41 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   (e)          (e)          P=0.106     |P=0.116N     P=0.234N     P=0.264N     P=0.225N     |
|POLY 3             |     P=0.011 *    (e)          (e)          P=0.116     |P=0.114N     P=0.241N     P=0.250N     P=0.235N     |
|POLY 1.5           |     P=0.011 *    (e)          (e)          P=0.119     |P=0.113N     P=0.241N     P=0.247N     P=0.235N     |
|POLY 6             |     P=0.011 *    (e)          (e)          P=0.112     |P=0.115N     P=0.239N     P=0.254N     P=0.233N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.106     |P=0.116N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.125     |P=0.114N     P=0.253N     P=0.253N     P=0.242N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small, Jejunum: Peyer's Patch                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/48 (0%)    2/49 (4%)   |1/49 (2%)    0/48 (0%)    0/48 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.2%        |2.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    2/42 (5%)   |1/46 (2%)    0/47 (0%)    0/42 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.219     |P=0.303N     P=0.496N     P=0.518N     P=0.487N     |
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.233     |P=0.305N     P=0.503N     P=0.509N     P=0.498N     |
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.237     |P=0.304N     P=0.503N     P=0.507N     P=0.498N     |
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.229     |P=0.307N     P=0.502N     P=0.511N     P=0.496N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.219     |P=0.303N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |P=0.304N     P=0.505N     P=0.505N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.1%         4.2%         4.1%         0.0%        |0.0%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     2/46 (4%)    2/46 (4%)    2/45 (4%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    1/43 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.183N     P=0.694      P=0.687      P=0.259N    |P=0.698      (e)          P=0.487      (e)          |
|POLY 3             |     P=0.170N     P=0.686      P=0.690      P=0.244N    |P=0.696      (e)          P=0.497      (e)          |
|POLY 1.5           |     P=0.167N     P=0.685      P=0.692      P=0.241N    |P=0.694      (e)          P=0.500      (e)          |
|POLY 6             |     P=0.176N     P=0.687      P=0.686      P=0.248N    |P=0.700      (e)          P=0.494      (e)          |
|LOGISTIC REGRESSION|     P=0.183N     P=0.694      P=0.687      (e)         |(e)          (e)          P=0.487      (e)          |
|COCH-ARM / FISHERS |     P=0.162N     P=0.684      P=0.691N     P=0.247N    |P=0.697      (e)          P=0.505      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.1%         0.0%         2.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/46 (4%)    0/46 (0%)    1/45 (2%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     665          ---          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.096N     P=0.123N     P=0.317N     P=0.138N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.086N     P=0.124N     P=0.311N     P=0.125N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.085N     P=0.124N     P=0.308N     P=0.122N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.087N     P=0.124N     P=0.316N     P=0.129N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.084N     P=0.119N     P=0.305N     P=0.115N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.086N     P=0.125N     P=0.309N     P=0.121N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.1%         0.0%         4.2%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |1/46 (2%)    0/47 (0%)    2/43 (5%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.449N     P=0.496N     P=0.476      P=0.487N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.457N     P=0.498N     P=0.495      P=0.498N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.458N     P=0.498N     P=0.500      P=0.498N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.454N     P=0.499N     P=0.490      P=0.496N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.449N     (e)          P=0.476      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.457N     P=0.495N     P=0.508      P=0.495N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     46/50 (92%)  49/49 (100%) 47/50 (94%)  43/50 (86%) |11/49 (22%)  7/50 (14%)   9/50 (18%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     92.0%        100.0%       96.0%        88.3%       |22.5%        14.3%        18.7%        6.1%         |
|TERMINAL (d)       |     42/46 (91%)  46/46 (100%) 45/45 (100%) 38/42 (91%) |9/46 (20%)   6/47 (13%)   6/43 (14%)   3/49 (6%)    |
|FIRST INCIDENCE    |     453          280          625          505         |654          664          669          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.526      P=0.268      P=0.368      P=0.510     |P=0.025N*    P=0.213N     P=0.461N     P=0.019N*    |
|POLY 3             |     P=0.120N     P=0.063      P=0.330      P=0.387N    |P=0.025N*    P=0.215N     P=0.418N     P=0.020N*    |
|POLY 1.5           |     P=0.084N     P=0.063      P=0.407      P=0.327N    |P=0.025N*    P=0.211N     P=0.404N     P=0.019N*    |
|POLY 6             |     P=0.199N     P=0.063      P=0.226      P=0.478N    |P=0.025N*    P=0.219N     P=0.433N     P=0.019N*    |
|LOGISTIC REGRESSION|     P=0.059N     (e)          P=0.520      P=0.297N    |P=0.023N*    P=0.179N     P=0.365N     P=0.018N*    |
|COCH-ARM / FISHERS |     P=0.057N     P=0.061      P=0.500      P=0.262N    |P=0.024N*    P=0.204N     P=0.382N     P=0.018N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.1%         0.0%        |0.0%         2.0%         8.4%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    2/43 (5%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          693          ---         |---          680          714          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.684      (e)          P=0.492      (e)         |P=0.603      P=0.500      P=0.060      (e)          |
|POLY 3             |     P=0.683      (e)          P=0.499      (e)         |P=0.595      P=0.502      P=0.059      (e)          |
|POLY 1.5           |     P=0.689      (e)          P=0.499      (e)         |P=0.592      P=0.503      P=0.061      (e)          |
|POLY 6             |     P=0.675      (e)          P=0.497      (e)         |P=0.601      P=0.503      P=0.057      (e)          |
|LOGISTIC REGRESSION|     P=0.696      (e)          P=0.487      (e)         |P=0.607      P=0.578      P=0.062      (e)          |
|COCH-ARM / FISHERS |     P=0.695      (e)          P=0.500      (e)         |P=0.596      P=0.505      P=0.061      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         2.1%         4.1%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    1/46 (2%)    2/45 (4%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.392N     P=0.761      P=0.492      P=0.518N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.375N     P=0.755      P=0.497      P=0.505N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.370N     P=0.755      P=0.499      P=0.503N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.382N     P=0.756      P=0.493      P=0.509N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.392N     P=0.761      P=0.492      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.365N     P=0.747      P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   5/50 (10%)   0/50 (0%)    2/50 (4%)   |2/49 (4%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.2%        10.3%        0.0%         4.2%        |4.1%         6.1%         0.0%         0.0%         |
|TERMINAL (d)       |     5/46 (11%)   5/46 (11%)   0/45 (0%)    2/42 (5%)   |2/46 (4%)    3/47 (6%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.096N     P=0.630      P=0.036N*    P=0.255N    |P=0.071N     P=0.510      P=0.253N     P=0.225N     |
|POLY 3             |     P=0.081N     P=0.628      P=0.032N*    P=0.228N    |P=0.072N     P=0.504      P=0.241N     P=0.235N     |
|POLY 1.5           |     P=0.080N     P=0.627      P=0.031N*    P=0.223N    |P=0.071N     P=0.506      P=0.238N     P=0.235N     |
|POLY 6             |     P=0.084N     P=0.629      P=0.033N*    P=0.236N    |P=0.071N     P=0.503      P=0.244N     P=0.233N     |
|LOGISTIC REGRESSION|     P=0.096N     P=0.630      (e)          P=0.255N    |P=0.071N     P=0.510      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.079N     P=0.630N     P=0.028N*    P=0.218N    |P=0.071N     P=0.510      P=0.242N     P=0.242N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   7/50 (14%)   9/50 (18%)  |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     8.2%         12.3%        14.5%        18.9%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     4/46 (9%)    6/46 (13%)   7/45 (16%)   9/42 (21%)  |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.058      P=0.370      P=0.249      P=0.085     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.079      P=0.368      P=0.256      P=0.106     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.084      P=0.367      P=0.260      P=0.111     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.072      P=0.370      P=0.250      P=0.099     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.058      P=0.370      P=0.249      P=0.085     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.088      P=0.370      P=0.262      P=0.117     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    6/50 (12%)  |0/49 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.1%         6.0%         4.1%         12.5%       |0.0%         6.1%         0.0%         0.0%         |
|TERMINAL (d)       |     3/46 (7%)    2/46 (4%)    1/45 (2%)    5/42 (12%)  |0/46 (0%)    3/47 (6%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      280          625          625         |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126      P=0.661      P=0.510N     P=0.205     |P=0.303N     P=0.125      (e)          (e)          |
|POLY 3             |     P=0.144      P=0.654N     P=0.501N     P=0.233     |P=0.311N     P=0.121      (e)          (e)          |
|POLY 1.5           |     P=0.148      P=0.657N     P=0.500N     P=0.238     |P=0.310N     P=0.121      (e)          (e)          |
|POLY 6             |     P=0.140      P=0.652N     P=0.504N     P=0.226     |P=0.310N     P=0.120      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.156      P=0.613N     P=0.505N     P=0.243     |(e)          P=0.125      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.151      P=0.661N     P=0.500N     P=0.243     |P=0.308N     P=0.125      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     30/50 (60%)  30/50 (60%)  26/50 (52%)  33/50 (66%) |40/49 (82%)  41/50 (82%)  39/50 (78%)  39/50 (78%)  |
|POLY-3 ADJUSTED (b)|     60.3%        61.5%        53.2%        68.4%       |81.8%        82.7%        78.9%        78.0%        |
|TERMINAL (d)       |     27/46 (59%)  30/46 (65%)  25/45 (56%)  29/42 (69%) |38/46 (83%)  40/47 (85%)  34/43 (79%)  38/49 (78%)  |
|FIRST INCIDENCE    |     453          729 (T)      597          625         |654          487          456          276          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.150      P=0.576      P=0.322N     P=0.181     |P=0.238N     P=0.583      P=0.454      P=0.287N     |
|POLY 3             |     P=0.260      P=0.533      P=0.306N     P=0.263     |P=0.318N     P=0.556      P=0.456N     P=0.414N     |
|POLY 1.5           |     P=0.287      P=0.543      P=0.291N     P=0.294     |P=0.325N     P=0.569      P=0.441N     P=0.418N     |
|POLY 6             |     P=0.228      P=0.526      P=0.328N     P=0.230     |P=0.305N     P=0.535      P=0.481N     P=0.408N     |
|LOGISTIC REGRESSION|     P=0.268      P=0.572      P=0.274N     P=0.304     |P=0.328N     P=0.571      P=0.420N     P=0.418N     |
|COCH-ARM / FISHERS |     P=0.322      P=0.581N     P=0.273N     P=0.339     |P=0.331N     P=0.584      P=0.421N     P=0.421N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         2.1%         4.1%         6.3%        |0.0%         2.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    1/46 (2%)    2/45 (4%)    3/42 (7%)   |0/46 (0%)    1/47 (2%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.139      P=0.761      P=0.492      P=0.274     |P=0.559N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.158      P=0.760      P=0.497      P=0.296     |P=0.569N     P=0.502      (e)          (e)          |
|POLY 1.5           |     P=0.162      P=0.759      P=0.499      P=0.300     |P=0.567N     P=0.502      (e)          (e)          |
|POLY 6             |     P=0.153      P=0.760      P=0.493      P=0.289     |P=0.569N     P=0.501      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.139      P=0.761      P=0.492      P=0.274     |(e)          P=0.504      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.165      P=0.753N     P=0.500      P=0.309     |P=0.565N     P=0.505      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis Focal                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    4/50 (8%)    3/50 (6%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     8.1%         6.2%         8.3%         6.3%        |0.0%         4.1%         0.0%         2.0%         |
|TERMINAL (d)       |     3/46 (7%)    3/46 (7%)    4/45 (9%)    3/42 (7%)   |0/46 (0%)    2/47 (4%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     453          729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.513N     P=0.502N     P=0.632      P=0.542N    |P=0.551      P=0.243      (e)          P=0.513      |
|POLY 3             |     P=0.485N     P=0.510N     P=0.629      P=0.523N    |P=0.539      P=0.239      (e)          P=0.502      |
|POLY 1.5           |     P=0.475N     P=0.508N     P=0.635      P=0.514N    |P=0.539      P=0.240      (e)          P=0.502      |
|POLY 6             |     P=0.498N     P=0.511N     P=0.620      P=0.536N    |P=0.541      P=0.239      (e)          P=0.504      |
|LOGISTIC REGRESSION|     P=0.454N     P=0.468N     P=0.635      P=0.464N    |(e)          P=0.243      (e)          P=0.513      |
|COCH-ARM / FISHERS |     P=0.463N     P=0.500N     P=0.643N     P=0.500N    |P=0.543      P=0.253      (e)          P=0.505      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Syncytial Alteration Focal                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    13/50 (26%)  17/50 (34%)  33/50 (66%) |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.1%         26.7%        34.5%        66.5%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/46 (4%)    13/46 (28%)  15/45 (33%)  28/42 (67%) |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      597          505         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 3             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|POLY 6             |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **  |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         6.1%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    3/49 (6%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.014 *    (e)          (e)          P=0.133      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.121      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.121      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.011 *    (e)          (e)          P=0.123      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.133      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.012 *    (e)          (e)          P=0.125      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Congestion                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.0%         0.0%         4.1%        |0.0%         0.0%         0.0%         2.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |     ---          711          ---          505         |---          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.132      P=0.500      (e)          P=0.232     |P=0.208      (e)          (e)          P=0.513      |
|POLY 3             |     P=0.138      P=0.500      (e)          P=0.234     |P=0.199      (e)          (e)          P=0.500      |
|POLY 1.5           |     P=0.139      P=0.499      (e)          P=0.236     |P=0.198      (e)          (e)          P=0.499      |
|POLY 6             |     P=0.135      P=0.501      (e)          P=0.231     |P=0.201      (e)          (e)          P=0.502      |
|LOGISTIC REGRESSION|     P=0.121      P=0.503      (e)          P=0.221     |(e)          (e)          (e)          P=0.513      |
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    7/50 (14%)   4/50 (8%)    1/50 (2%)   |1/50 (2%)    5/50 (10%)   2/50 (4%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     0.0%         14.4%        8.2%         2.1%        |2.0%         10.2%        4.2%         10.2%        |
|TERMINAL (d)       |     0/46 (0%)    7/46 (15%)   3/45 (7%)    0/42 (0%)   |1/46 (2%)    4/47 (9%)    2/43 (5%)    5/49 (10%)   |
|FIRST INCIDENCE    |     ---          729 (T)      689          597         |729 (T)      680          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.465N     P=0.009 **   P=0.062      P=0.496     |P=0.176      P=0.110      P=0.476      P=0.119      |
|POLY 3             |     P=0.433N     P=0.008 **   P=0.060      P=0.496     |P=0.152      P=0.102      P=0.490      P=0.102      |
|POLY 1.5           |     P=0.426N     P=0.008 **   P=0.060      P=0.498     |P=0.151      P=0.102      P=0.494      P=0.101      |
|POLY 6             |     P=0.444N     P=0.008 **   P=0.059      P=0.494     |P=0.156      P=0.103      P=0.487      P=0.105      |
|LOGISTIC REGRESSION|     P=0.416N     P=0.009 **   P=0.063      P=0.479     |P=0.155      P=0.104      P=0.476      P=0.119      |
|COCH-ARM / FISHERS |     P=0.420N     P=0.006 **   P=0.059      P=0.500     |P=0.154      P=0.102      P=0.500      P=0.102      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.1%         2.1%        |0.0%         0.0%         4.2%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    1/46 (2%)    1/45 (2%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    1/43 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      597         |---          ---          625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.366      P=0.500      P=0.496      P=0.496     |P=0.597      (e)          P=0.228      (e)          |
|POLY 3             |     P=0.378      P=0.499      P=0.498      P=0.496     |P=0.597      (e)          P=0.233      (e)          |
|POLY 1.5           |     P=0.381      P=0.499      P=0.499      P=0.498     |P=0.594      (e)          P=0.234      (e)          |
|POLY 6             |     P=0.372      P=0.500      P=0.496      P=0.494     |P=0.604      (e)          P=0.232      (e)          |
|LOGISTIC REGRESSION|     P=0.381      P=0.500      P=0.496      P=0.479     |P=0.650      (e)          P=0.298      (e)          |
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.595      (e)          P=0.247      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Mixed Cell                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.2%        |0.0%         2.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          681         |---          487          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.042 *    (e)          (e)          P=0.225     |P=0.571N     P=0.500      (e)          (e)          |
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.232     |P=0.568N     P=0.502      (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.235     |P=0.568N     P=0.501      (e)          (e)          |
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.229     |P=0.567N     P=0.503      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.047 *    (e)          (e)          P=0.245     |P=0.245N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Bronchiolization                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    20/50 (40%)  30/50 (60%)  48/50 (96%) |0/50 (0%)    33/50 (66%)  41/50 (82%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|     0.0%         41.0%        61.9%        96.7%       |0.0%         67.2%        83.7%        99.9%        |
|TERMINAL (d)       |     0/46 (0%)    20/46 (44%)  30/45 (67%)  41/42 (98%) |0/46 (0%)    32/47 (68%)  37/43 (86%)  49/49 (100%) |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      505         |---          664          534          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    6/50 (12%)  |2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.0%         2.1%         8.3%         12.6%       |4.1%         2.0%         4.2%         2.0%         |
|TERMINAL (d)       |     1/46 (2%)    1/46 (2%)    4/45 (9%)    6/42 (14%)  |2/46 (4%)    1/47 (2%)    2/43 (5%)    1/49 (2%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   P=0.761      P=0.174      P=0.045 *   |P=0.427N     P=0.492N     P=0.670      P=0.478N     |
|POLY 3             |     P=0.012 *    P=0.760      P=0.176      P=0.052     |P=0.445N     P=0.502N     P=0.683      P=0.500N     |
|POLY 1.5           |     P=0.012 *    P=0.759      P=0.178      P=0.054     |P=0.447N     P=0.501N     P=0.687      P=0.502N     |
|POLY 6             |     P=0.011 *    P=0.760      P=0.173      P=0.049 *   |P=0.442N     P=0.501N     P=0.680      P=0.496N     |
|LOGISTIC REGRESSION|     P=0.009 **   P=0.761      P=0.174      P=0.045 *   |P=0.427N     P=0.492N     P=0.670      P=0.478N     |
|COCH-ARM / FISHERS |     P=0.013 *    P=0.753N     P=0.181      P=0.056     |P=0.444N     P=0.500N     P=0.691N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         0.0%         0.0%         0.0%        |0.0%         2.0%         4.2%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    1/47 (2%)    2/43 (5%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.316N     P=0.500N     P=0.504N     P=0.518N    |P=0.601N     P=0.504      P=0.224      (e)          |
|POLY 3             |     P=0.303N     P=0.501N     P=0.502N     P=0.505N    |P=0.616N     P=0.499      P=0.231      (e)          |
|POLY 1.5           |     P=0.304N     P=0.501N     P=0.501N     P=0.503N    |P=0.618N     P=0.499      P=0.233      (e)          |
|POLY 6             |     P=0.302N     P=0.500N     P=0.504N     P=0.509N    |P=0.611N     P=0.500      P=0.229      (e)          |
|LOGISTIC REGRESSION|     P=0.316N     (e)          (e)          (e)         |(e)          P=0.504      P=0.224      (e)          |
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.616N     P=0.500      P=0.247      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Bronchial                                                                                                            |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         2.1%         0.0%        |0.0%         0.0%         6.3%         2.0%         |
|TERMINAL (d)       |     0/46 (0%)    1/46 (2%)    1/45 (2%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    3/43 (7%)    1/49 (2%)    |
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |---          ---          729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.615N     P=0.500      P=0.496      (e)         |P=0.263      (e)          P=0.110      P=0.513      |
|POLY 3             |     P=0.602N     P=0.499      P=0.498      (e)         |P=0.247      (e)          P=0.114      P=0.500      |
|POLY 1.5           |     P=0.598N     P=0.499      P=0.499      (e)         |P=0.245      (e)          P=0.116      P=0.499      |
|POLY 6             |     P=0.607N     P=0.500      P=0.496      (e)         |P=0.253      (e)          P=0.112      P=0.502      |
|LOGISTIC REGRESSION|     (e)          P=0.500      P=0.496      (e)         |(e)          (e)          P=0.110      P=0.513      |
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.247      (e)          P=0.121      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    1/45 (2%)    1/48 (2%)   |0/50 (0%)    1/48 (2%)    2/48 (4%)    0/47 (0%)    |
|POLY-3 ADJUSTED (b)|     2.1%         0.0%         2.3%         2.2%        |0.0%         2.1%         4.4%         0.0%         |
|TERMINAL (d)       |     1/45 (2%)    0/46 (0%)    1/41 (2%)    1/40 (3%)   |0/46 (0%)    1/45 (2%)    2/41 (5%)    0/46 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |---          729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.504      P=0.496N     P=0.741      P=0.735     |P=0.615N     P=0.496      P=0.214      (e)          |
|POLY 3             |     P=0.523      P=0.493N     P=0.743      P=0.753     |P=0.630N     P=0.491      P=0.222      (e)          |
|POLY 1.5           |     P=0.529      P=0.493N     P=0.745      P=0.756     |P=0.632N     P=0.491      P=0.224      (e)          |
|POLY 6             |     P=0.516      P=0.493N     P=0.739      P=0.747     |P=0.625N     P=0.491      P=0.220      (e)          |
|LOGISTIC REGRESSION|     P=0.504      (e)          P=0.741      P=0.735     |(e)          P=0.496      P=0.214      (e)          |
|COCH-ARM / FISHERS |     P=0.534      P=0.490N     P=0.736      P=0.753N    |P=0.630N     P=0.490      P=0.237      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/49 (0%)    1/49 (2%)   |0/48 (0%)    1/49 (2%)    2/49 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         2.1%        |0.0%         2.1%         4.3%         4.1%         |
|TERMINAL (d)       |     0/46 (0%)    1/46 (2%)    0/44 (0%)    0/42 (0%)   |0/46 (0%)    1/46 (2%)    1/42 (2%)    2/49 (4%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          689         |---          729 (T)      716          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.387      P=0.500      (e)          P=0.487     |P=0.178      P=0.500      P=0.225      P=0.253      |
|POLY 3             |     P=0.398      P=0.496      (e)          P=0.493     |P=0.166      P=0.501      P=0.233      P=0.244      |
|POLY 1.5           |     P=0.400      P=0.495      (e)          P=0.494     |P=0.166      P=0.502      P=0.237      P=0.244      |
|POLY 6             |     P=0.395      P=0.496      (e)          P=0.491     |P=0.168      P=0.500      P=0.230      P=0.245      |
|LOGISTIC REGRESSION|     P=0.403      P=0.500      (e)          P=0.499     |P=0.168      P=0.500      P=0.236      P=0.253      |
|COCH-ARM / FISHERS |     P=0.402      P=0.495      (e)          P=0.495     |P=0.168      P=0.505      P=0.253      P=0.258      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    1/49 (2%)   |2/48 (4%)    5/49 (10%)   0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.1%        |4.2%         10.4%        0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/44 (0%)    1/42 (2%)   |2/46 (4%)    5/46 (11%)   0/42 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.482     |P=0.050N     P=0.217      P=0.259N     P=0.225N     |
|POLY 3             |     P=0.195      (e)          (e)          P=0.492     |P=0.048N*    P=0.219      P=0.242N     P=0.231N     |
|POLY 1.5           |     P=0.196      (e)          (e)          P=0.494     |P=0.047N*    P=0.221      P=0.238N     P=0.231N     |
|POLY 6             |     P=0.193      (e)          (e)          P=0.489     |P=0.048N*    P=0.216      P=0.246N     P=0.230N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.482     |P=0.050N     P=0.217      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.197      (e)          (e)          P=0.495     |P=0.048N*    P=0.226      P=0.242N     P=0.237N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/0 (0%)    |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.2%         0.0%         |
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/0 (0%)    |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          625          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.598      (e)          P=0.233      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.597      (e)          P=0.233      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.594      (e)          P=0.235      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.604      (e)          P=0.232      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.662      (e)          P=0.311      (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/6 (17%)    1/7 (14%)    1/8 (13%)    2/5 (40%)   |0/3 (0%)     2/3 (67%)    1/4 (25%)    1/7 (14%)    |
|POLY-3 ADJUSTED (b)|     16.7%        14.4%        13.5%        40.0%       |0.0%         66.7%        25.3%        14.3%        |
|TERMINAL (d)       |     0/5 (0%)     0/5 (0%)     0/5 (0%)     2/5 (40%)   |0/2 (0%)     2/3 (67%)    0/2 (0%)     1/7 (14%)    |
|FIRST INCIDENCE    |     665          280          597          729 (T)     |---          729 (T)      714          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.338      P=0.760      P=0.753      P=0.487     |P=0.462N     P=0.309      P=0.496      P=0.748      |
|POLY 3             |     P=0.268      P=0.728N     P=0.715N     P=0.431     |P=0.427N     P=0.185      P=0.572      P=0.678      |
|POLY 1.5           |     P=0.270      P=0.727N     P=0.706N     P=0.431     |P=0.449N     P=0.172      P=0.565      P=0.671      |
|POLY 6             |     P=0.266      P=0.730N     P=0.727N     P=0.431     |P=0.392N     P=0.209      P=0.584      P=0.689      |
|LOGISTIC REGRESSION|     P=0.151      (e)          P=0.382N     P=0.487     |P=0.425N     P=0.309      P=0.564      P=0.748      |
|COCH-ARM / FISHERS |     P=0.263      P=0.731N     P=0.692N     P=0.424     |P=0.474N     P=0.200      P=0.571      P=0.700      |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/6 (67%)    4/7 (57%)    4/8 (50%)    2/5 (40%)   |1/3 (33%)    1/3 (33%)    1/4 (25%)    1/7 (14%)    |
|POLY-3 ADJUSTED (b)|     69.5%        66.7%        57.5%        40.0%       |36.7%        33.3%        25.3%        14.3%        |
|TERMINAL (d)       |     4/5 (80%)    4/5 (80%)    4/5 (80%)    2/5 (40%)   |1/2 (50%)    1/3 (33%)    0/2 (0%)     1/7 (14%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      714          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.130N     P=0.773      P=0.773      P=0.270N    |P=0.332N     P=0.691N     P=0.758      P=0.460N     |
|POLY 3             |     P=0.226N     P=0.690N     P=0.557N     P=0.367N    |P=0.334N     P=0.743N     P=0.678N     P=0.538N     |
|POLY 1.5           |     P=0.242N     P=0.673N     P=0.516N     P=0.381N    |P=0.341N     P=0.751N     P=0.687N     P=0.550N     |
|POLY 6             |     P=0.206N     P=0.684N     P=0.620N     P=0.342N    |P=0.323N     P=0.727N     P=0.664N     P=0.519N     |
|LOGISTIC REGRESSION|     P=0.130N     P=0.773      P=0.773      P=0.270N    |P=0.281N     P=0.691N     P=0.685N     P=0.460N     |
|COCH-ARM / FISHERS |     P=0.266N     P=0.587N     P=0.471N     P=0.392N    |P=0.333N     P=0.800N     P=0.714N     P=0.533N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Sinus                                                                                                                      |
|     Foreign Body                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         4.1%         4.1%         4.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    2/46 (4%)    2/45 (4%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      721         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.386      P=0.500      P=0.492      P=0.469     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.410      P=0.499      P=0.497      P=0.491     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.417      P=0.498      P=0.499      P=0.495     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.400      P=0.500      P=0.493      P=0.484     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.392      P=0.500      P=0.492      P=0.481     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.423      P=0.500      P=0.500      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Sinus                                                                                                                      |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         6.2%         6.2%         4.2%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    3/46 (7%)    3/45 (7%)    1/42 (2%)   |0/46 (0%)    0/47 (0%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      721         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.434      P=0.306      P=0.298      P=0.469     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.460      P=0.305      P=0.302      P=0.491     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.469      P=0.304      P=0.304      P=0.495     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.448      P=0.306      P=0.298      P=0.484     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.440      P=0.306      P=0.298      P=0.481     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.477      P=0.309      P=0.309      P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/48 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.1%         4.1%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |1/45 (2%)    2/47 (4%)    0/43 (0%)    0/48 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.183N     P=0.515      P=0.509N     P=0.487N     |
|POLY 3             |                                                        |P=0.188N     P=0.510      P=0.499N     P=0.497N     |
|POLY 1.5           |                                                        |P=0.187N     P=0.512      P=0.496N     P=0.498N     |
|POLY 6             |                                                        |P=0.188N     P=0.509      P=0.502N     P=0.496N     |
|LOGISTIC REGRESSION|                                                        |P=0.183N     P=0.515      (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.185N     P=0.515      P=0.490N     P=0.495N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |12/48 (25%)  14/50 (28%)  13/50 (26%)  13/49 (27%)  |
|POLY-3 ADJUSTED (b)|                                                        |25.3%        28.1%        27.1%        27.1%        |
|TERMINAL (d)       |                                                        |12/45 (27%)  12/47 (26%)  11/43 (26%)  13/48 (27%)  |
|FIRST INCIDENCE    |                                                        |729 (T)      487          669          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.530N     P=0.457      P=0.450      P=0.574      |
|POLY 3             |                                                        |P=0.497      P=0.465      P=0.514      P=0.514      |
|POLY 1.5           |                                                        |P=0.498      P=0.462      P=0.526      P=0.513      |
|POLY 6             |                                                        |P=0.504      P=0.471      P=0.503      P=0.524      |
|LOGISTIC REGRESSION|                                                        |P=0.509      P=0.499      P=0.491      P=0.574      |
|COCH-ARM / FISHERS |                                                        |P=0.514      P=0.458      P=0.547      P=0.524      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/48 (2%)    2/50 (4%)    5/50 (10%)   0/49 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.1%         4.1%         10.5%        0.0%         |
|TERMINAL (d)       |                                                        |1/45 (2%)    2/47 (4%)    4/43 (9%)    0/48 (0%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      716          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.386N     P=0.515      P=0.096      P=0.487N     |
|POLY 3             |                                                        |P=0.401N     P=0.510      P=0.103      P=0.497N     |
|POLY 1.5           |                                                        |P=0.403N     P=0.512      P=0.107      P=0.498N     |
|POLY 6             |                                                        |P=0.395N     P=0.509      P=0.100      P=0.496N     |
|LOGISTIC REGRESSION|                                                        |P=0.398N     P=0.515      P=0.100      (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.398N     P=0.515      P=0.112      P=0.495N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy Diffuse                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.1%         0.0%        |4.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    1/45 (2%)    0/42 (0%)   |2/46 (4%)    0/47 (0%)    0/42 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.684      (e)          P=0.496      (e)         |P=0.115N     P=0.234N     P=0.259N     P=0.225N     |
|POLY 3             |     P=0.683      (e)          P=0.498      (e)         |P=0.112N     P=0.235N     P=0.245N     P=0.235N     |
|POLY 1.5           |     P=0.688      (e)          P=0.499      (e)         |P=0.112N     P=0.235N     P=0.242N     P=0.235N     |
|POLY 6             |     P=0.675      (e)          P=0.496      (e)         |P=0.113N     P=0.236N     P=0.249N     P=0.233N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.496      (e)         |P=0.115N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.114N     P=0.242N     P=0.247N     P=0.242N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Duct                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |3/49 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.0%         0.0%         2.1%         0.0%        |6.2%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    0/46 (0%)    1/45 (2%)    0/42 (0%)   |3/46 (7%)    0/47 (0%)    1/42 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |729 (T)      ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.424N     P=0.500N     P=0.757      P=0.518N    |P=0.085N     P=0.118N     P=0.338N     P=0.111N     |
|POLY 3             |     P=0.410N     P=0.501N     P=0.758      P=0.505N    |P=0.083N     P=0.118N     P=0.319N     P=0.117N     |
|POLY 1.5           |     P=0.407N     P=0.501N     P=0.759      P=0.503N    |P=0.084N     P=0.117N     P=0.314N     P=0.117N     |
|POLY 6             |     P=0.413N     P=0.500N     P=0.756      P=0.509N    |P=0.083N     P=0.118N     P=0.324N     P=0.115N     |
|LOGISTIC REGRESSION|     P=0.424N     (e)          P=0.757      (e)         |P=0.085N     (e)          P=0.338N     (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.085N     P=0.117N     P=0.309N     P=0.117N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/45 (0%)    0/44 (0%)    3/50 (6%)   |0/49 (0%)    0/48 (0%)    1/44 (2%)    0/48 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         6.3%        |0.0%         0.0%         2.4%         0.0%         |
|TERMINAL (d)       |     0/44 (0%)    0/41 (0%)    0/39 (0%)    3/42 (7%)   |0/45 (0%)    0/45 (0%)    1/37 (3%)    0/47 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.012 *    (e)          (e)          P=0.113     |P=0.692      (e)          P=0.461      (e)          |
|POLY 3             |     P=0.013 *    (e)          (e)          P=0.121     |P=0.691      (e)          P=0.472      (e)          |
|POLY 1.5           |     P=0.014 *    (e)          (e)          P=0.124     |P=0.688      (e)          P=0.474      (e)          |
|POLY 6             |     P=0.013 *    (e)          (e)          P=0.118     |P=0.697      (e)          P=0.469      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.113     |(e)          (e)          P=0.461      (e)          |
|COCH-ARM / FISHERS |     P=0.015 *    (e)          (e)          P=0.129     |P=0.689      (e)          P=0.473      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/46 (4%)    1/49 (2%)    1/49 (2%)    0/45 (0%)   |0/45 (0%)    0/49 (0%)    1/49 (2%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     4.4%         2.1%         2.1%         0.0%        |0.0%         0.0%         2.1%         0.0%         |
|TERMINAL (d)       |     2/43 (5%)    1/46 (2%)    1/45 (2%)    0/40 (0%)   |0/41 (0%)    0/46 (0%)    1/43 (2%)    0/45 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.164N     P=0.476N     P=0.484N     P=0.254N    |P=0.702      (e)          P=0.510      (e)          |
|POLY 3             |     P=0.159N     P=0.472N     P=0.478N     P=0.245N    |P=0.705      (e)          P=0.512      (e)          |
|POLY 1.5           |     P=0.158N     P=0.474N     P=0.477N     P=0.243N    |P=0.701      (e)          P=0.514      (e)          |
|POLY 6             |     P=0.161N     P=0.471N     P=0.480N     P=0.247N    |P=0.711      (e)          P=0.511      (e)          |
|LOGISTIC REGRESSION|     P=0.164N     P=0.476N     P=0.484N     (e)         |(e)          (e)          P=0.510      (e)          |
|COCH-ARM / FISHERS |     P=0.155N     P=0.476N     P=0.476N     P=0.253N    |P=0.695      (e)          P=0.521      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cytoplasmic Alteration Focal                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    0/49 (0%)    0/49 (0%)    0/45 (0%)   |4/45 (9%)    2/49 (4%)    3/49 (6%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |9.1%         4.2%         6.4%         0.0%         |
|TERMINAL (d)       |     0/43 (0%)    0/46 (0%)    0/45 (0%)    0/40 (0%)   |4/41 (10%)   2/46 (4%)    3/43 (7%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.052N     P=0.285N     P=0.474N     P=0.052N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.056N     P=0.300N     P=0.466N     P=0.057N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.057N     P=0.300N     P=0.462N     P=0.059N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.054N     P=0.299N     P=0.469N     P=0.056N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.052N     P=0.285N     P=0.474N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.059N     P=0.299N     P=0.452N     P=0.058N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia Focal                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    1/49 (2%)    0/49 (0%)    0/45 (0%)   |0/45 (0%)    2/49 (4%)    0/49 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |0.0%         4.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/43 (0%)    1/46 (2%)    0/45 (0%)    0/40 (0%)   |0/41 (0%)    2/46 (4%)    0/43 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.582N     P=0.513      (e)          (e)         |P=0.393N     P=0.264      (e)          (e)          |
|POLY 3             |     P=0.572N     P=0.516      (e)          (e)         |P=0.406N     P=0.256      (e)          (e)          |
|POLY 1.5           |     P=0.572N     P=0.515      (e)          (e)         |P=0.407N     P=0.256      (e)          (e)          |
|POLY 6             |     P=0.573N     P=0.517      (e)          (e)         |P=0.403N     P=0.257      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.513      (e)          (e)         |(e)          P=0.264      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.574N     P=0.516      (e)          (e)         |P=0.407N     P=0.269      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  31/50 (62%)  32/50 (64%)  28/50 (56%) |                                                    |
|POLY-3 ADJUSTED (b)|     57.2%        63.4%        65.3%        57.3%       |                                                    |
|TERMINAL (d)       |     28/46 (61%)  30/46 (65%)  30/45 (67%)  24/42 (57%) |                                                    |
|FIRST INCIDENCE    |     729 (T)      689          597          585         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.359      P=0.338      P=0.225      P=0.389     |                                                    |
|POLY 3             |     P=0.492N     P=0.341      P=0.272      P=0.579     |                                                    |
|POLY 1.5           |     P=0.487N     P=0.334      P=0.274      P=0.580N    |                                                    |
|POLY 6             |     P=0.504N     P=0.352      P=0.263      P=0.574     |                                                    |
|LOGISTIC REGRESSION|     P=0.526      P=0.339      P=0.230      P=0.538     |                                                    |
|COCH-ARM / FISHERS |     P=0.490N     P=0.342      P=0.270      P=0.580N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     6.1%         4.1%         2.1%         0.0%        |                                                    |
|TERMINAL (d)       |     3/46 (7%)    2/46 (4%)    1/45 (2%)    0/42 (0%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.071N     P=0.500N     P=0.313N     P=0.138N    |                                                    |
|POLY 3             |     P=0.064N     P=0.501N     P=0.309N     P=0.124N    |                                                    |
|POLY 1.5           |     P=0.063N     P=0.502N     P=0.307N     P=0.122N    |                                                    |
|POLY 6             |     P=0.066N     P=0.500N     P=0.313N     P=0.128N    |                                                    |
|LOGISTIC REGRESSION|     P=0.071N     P=0.500N     P=0.313N     (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.062N     P=0.500N     P=0.309N     P=0.121N    |                                                    |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Inflammation Chronic Focal                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         4.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    2/47 (4%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.396N     P=0.243      (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.407N     P=0.236      (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.407N     P=0.237      (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.237      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.243      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis Focal                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     4.1%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/46 (2%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    0/47 (0%)    0/42 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     721          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.123N     P=0.242N     P=0.247N     P=0.260N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.113N     P=0.238N     P=0.240N     P=0.244N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.113N     P=0.239N     P=0.238N     P=0.241N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.113N     P=0.238N     P=0.242N     P=0.248N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.117N     P=0.238N     P=0.240N     P=0.245N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   15/50 (30%)  10/50 (20%)  11/50 (22%) |2/49 (4%)    7/50 (14%)   11/49 (22%)  4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     18.1%        30.8%        20.2%        22.8%       |4.1%         14.3%        22.6%        8.2%         |
|TERMINAL (d)       |     8/46 (17%)   15/46 (33%)  6/45 (13%)   7/42 (17%)  |0/46 (0%)    6/47 (13%)   5/42 (12%)   4/49 (8%)    |
|FIRST INCIDENCE    |     453          729 (T)      597          625         |682          680          456          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.439      P=0.122      P=0.482      P=0.334     |P=0.418      P=0.090      P=0.010 *    P=0.364      |
|POLY 3             |     P=0.506      P=0.110      P=0.498      P=0.376     |P=0.380      P=0.081      P=0.007 **   P=0.341      |
|POLY 1.5           |     P=0.518      P=0.112      P=0.498      P=0.386     |P=0.381      P=0.083      P=0.007 **   P=0.341      |
|POLY 6             |     P=0.493      P=0.109      P=0.498      P=0.365     |P=0.385      P=0.080      P=0.007 **   P=0.342      |
|LOGISTIC REGRESSION|     P=0.537N     P=0.123      P=0.584      P=0.446     |P=0.459      P=0.096      P=0.029 *    P=0.354      |
|COCH-ARM / FISHERS |     P=0.534      P=0.121      P=0.500      P=0.402     |P=0.395      P=0.085      P=0.007 **   P=0.349      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |5/49 (10%)   9/50 (18%)   4/49 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     6.1%         4.1%         2.1%         2.1%        |10.3%        18.4%        8.6%         4.1%         |
|TERMINAL (d)       |     3/46 (7%)    2/46 (4%)    1/45 (2%)    1/42 (2%)   |5/46 (11%)   9/47 (19%)   4/42 (10%)   2/49 (4%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.223N     P=0.500N     P=0.313N     P=0.338N    |P=0.067N     P=0.206      P=0.557N     P=0.193N     |
|POLY 3             |     P=0.206N     P=0.501N     P=0.309N     P=0.315N    |P=0.074N     P=0.198      P=0.522N     P=0.212N     |
|POLY 1.5           |     P=0.203N     P=0.502N     P=0.307N     P=0.311N    |P=0.074N     P=0.201      P=0.514N     P=0.213N     |
|POLY 6             |     P=0.210N     P=0.500N     P=0.313N     P=0.322N    |P=0.072N     P=0.197      P=0.531N     P=0.209N     |
|LOGISTIC REGRESSION|     P=0.223N     P=0.500N     P=0.313N     P=0.338N    |P=0.067N     P=0.206      P=0.557N     P=0.193N     |
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.309N     P=0.309N    |P=0.073N     P=0.205      P=0.500N     P=0.210N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Diverticulum                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    5/50 (10%)   1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.1%         0.0%        |0.0%         10.2%        2.1%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    1/45 (2%)    0/42 (0%)   |0/46 (0%)    5/47 (11%)   1/43 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.684      (e)          P=0.496      (e)         |P=0.231N     P=0.036 *    P=0.487      (e)          |
|POLY 3             |     P=0.683      (e)          P=0.498      (e)         |P=0.238N     P=0.032 *    P=0.497      (e)          |
|POLY 1.5           |     P=0.688      (e)          P=0.499      (e)         |P=0.238N     P=0.032 *    P=0.500      (e)          |
|POLY 6             |     P=0.675      (e)          P=0.496      (e)         |P=0.236N     P=0.031 *    P=0.494      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.496      (e)         |(e)          P=0.036 *    P=0.487      (e)          |
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.237N     P=0.030 *    P=0.505      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   0/50 (0%)    2/50 (4%)   |0/49 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     6.0%         10.0%        0.0%         4.1%        |0.0%         4.1%         0.0%         0.0%         |
|TERMINAL (d)       |     2/46 (4%)    3/46 (7%)    0/45 (0%)    0/42 (0%)   |0/46 (0%)    2/47 (4%)    0/43 (0%)    0/49 (0%)    |
|FIRST INCIDENCE    |     453          280          ---          597         |---          729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.247N     P=0.360      P=0.126N     P=0.524N    |P=0.396N     P=0.243      (e)          (e)          |
|POLY 3             |     P=0.230N     P=0.359      P=0.124N     P=0.514N    |P=0.406N     P=0.239      (e)          (e)          |
|POLY 1.5           |     P=0.226N     P=0.358      P=0.122N     P=0.508N    |P=0.405N     P=0.240      (e)          (e)          |
|POLY 6             |     P=0.235N     P=0.361      P=0.127N     P=0.520N    |P=0.406N     P=0.239      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.166N     P=0.309      P=0.137N     P=0.419N    |(e)          P=0.243      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.221N     P=0.357      P=0.121N     P=0.500N    |P=0.402N     P=0.253      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Germinal Epithelium                                                                                                      |
|     Degeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         6.0%         2.1%        |                                                    |
|TERMINAL (d)       |     0/46 (0%)    0/46 (0%)    0/45 (0%)    0/42 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          ---          597          625         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.240      (e)          P=0.124      P=0.492     |                                                    |
|POLY 3             |     P=0.236      (e)          P=0.122      P=0.496     |                                                    |
|POLY 1.5           |     P=0.241      (e)          P=0.121      P=0.498     |                                                    |
|POLY 6             |     P=0.229      (e)          P=0.123      P=0.493     |                                                    |
|LOGISTIC REGRESSION|     P=0.202      (e)          P=0.039 *    P=0.493     |                                                    |
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    0/40 (0%)    0/44 (0%)    0/45 (0%)   |1/48 (2%)    2/49 (4%)    0/47 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.1%         4.2%         0.0%         0.0%         |
|TERMINAL (d)       |     0/44 (0%)    0/39 (0%)    0/40 (0%)    0/39 (0%)   |1/45 (2%)    2/46 (4%)    0/42 (0%)    0/45 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.193N     P=0.508      P=0.514N     P=0.500N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.504      P=0.510N     P=0.510N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.505      P=0.508N     P=0.510N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.504      P=0.511N     P=0.508N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.193N     P=0.508      (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.196N     P=0.508      P=0.505N     P=0.511N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/47 (6%)    3/40 (8%)    1/44 (2%)    0/45 (0%)   |1/48 (2%)    1/49 (2%)    2/47 (4%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     6.5%         7.7%         2.3%         0.0%        |2.1%         2.1%         4.4%         0.0%         |
|TERMINAL (d)       |     3/44 (7%)    3/39 (8%)    1/40 (3%)    0/39 (0%)   |0/45 (0%)    1/46 (2%)    2/42 (5%)    0/45 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |707          729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.063N     P=0.606      P=0.340N     P=0.143N    |P=0.369N     P=0.758N     P=0.479      P=0.492N     |
|POLY 3             |     P=0.057N     P=0.583      P=0.332N     P=0.131N    |P=0.383N     P=0.758N     P=0.482      P=0.510N     |
|POLY 1.5           |     P=0.055N     P=0.582      P=0.330N     P=0.129N    |P=0.384N     P=0.757N     P=0.486      P=0.510N     |
|POLY 6             |     P=0.059N     P=0.585      P=0.336N     P=0.135N    |P=0.380N     P=0.759N     P=0.479      P=0.508N     |
|LOGISTIC REGRESSION|     P=0.063N     P=0.606      P=0.340N     (e)         |P=0.382N     P=0.754N     P=0.489      P=0.498N     |
|COCH-ARM / FISHERS |     P=0.054N     P=0.582      P=0.334N     P=0.129N    |P=0.381N     P=0.747N     P=0.492      P=0.511N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/47 (2%)    0/40 (0%)    0/44 (0%)    1/45 (2%)   |0/48 (0%)    0/49 (0%)    2/47 (4%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     2.2%         0.0%         0.0%         2.3%        |0.0%         0.0%         4.4%         0.0%         |
|TERMINAL (d)       |     1/44 (2%)    0/39 (0%)    0/40 (0%)    1/39 (3%)   |0/45 (0%)    0/46 (0%)    2/42 (5%)    0/45 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.575      P=0.524N     P=0.519N     P=0.735     |P=0.591      (e)          P=0.223      (e)          |
|POLY 3             |     P=0.589      P=0.533N     P=0.515N     P=0.745     |P=0.585      (e)          P=0.226      (e)          |
|POLY 1.5           |     P=0.592      P=0.534N     P=0.514N     P=0.748     |P=0.582      (e)          P=0.229      (e)          |
|POLY 6             |     P=0.586      P=0.532N     P=0.517N     P=0.741     |P=0.592      (e)          P=0.225      (e)          |
|LOGISTIC REGRESSION|     P=0.575      (e)          (e)          P=0.735     |(e)          (e)          P=0.223      (e)          |
|COCH-ARM / FISHERS |     P=0.594      P=0.540N     P=0.516N     P=0.742     |P=0.585      (e)          P=0.242      (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Degeneration Cystic Focal                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  9/50 (18%)   13/49 (27%)  15/49 (31%) |18/50 (36%)  27/50 (54%)  29/49 (59%)  22/50 (44%)  |
|POLY-3 ADJUSTED (b)|     20.4%        18.1%        27.4%        31.8%       |36.5%        55.3%        59.9%        44.8%        |
|TERMINAL (d)       |     10/46 (22%)  8/46 (17%)   13/44 (30%)  13/41 (32%) |17/46 (37%)  27/47 (57%)  25/42 (60%)  22/49 (45%)  |
|FIRST INCIDENCE    |     729 (T)      280          729 (T)      597         |654          729 (T)      456          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.047 *    P=0.500N     P=0.273      P=0.110     |P=0.444      P=0.064      P=0.011 *    P=0.360      |
|POLY 3             |     P=0.071      P=0.484N     P=0.288      P=0.150     |P=0.335      P=0.046 *    P=0.015 *    P=0.261      |
|POLY 1.5           |     P=0.076      P=0.490N     P=0.294      P=0.156     |P=0.329      P=0.048 *    P=0.015 *    P=0.259      |
|POLY 6             |     P=0.065      P=0.481N     P=0.276      P=0.142     |P=0.354      P=0.044 *    P=0.015 *    P=0.272      |
|LOGISTIC REGRESSION|     P=0.085      P=0.481N     P=0.273      P=0.147     |P=0.338      P=0.052      P=0.022 *    P=0.271      |
|COCH-ARM / FISHERS |     P=0.081      P=0.500N     P=0.298      P=0.163     |P=0.347      P=0.054      P=0.017 *    P=0.270      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    0/49 (0%)   |1/50 (2%)    3/50 (6%)    1/49 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.1%         0.0%         0.0%        |2.0%         6.1%         2.1%         0.0%         |
|TERMINAL (d)       |     0/46 (0%)    1/46 (2%)    0/44 (0%)    0/41 (0%)   |1/46 (2%)    3/47 (6%)    1/42 (2%)    0/49 (0%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.586N     P=0.500      (e)          (e)         |P=0.193N     P=0.313      P=0.741      P=0.487N     |
|POLY 3             |     P=0.573N     P=0.499      (e)          (e)         |P=0.202N     P=0.304      P=0.749      P=0.500N     |
|POLY 1.5           |     P=0.572N     P=0.499      (e)          (e)         |P=0.203N     P=0.304      P=0.752      P=0.501N     |
|POLY 6             |     P=0.574N     P=0.500      (e)          (e)         |P=0.199N     P=0.305      P=0.747      P=0.498N     |
|LOGISTIC REGRESSION|     (e)          P=0.500      (e)          (e)         |P=0.193N     P=0.313      P=0.741      (e)          |
|COCH-ARM / FISHERS |     P=0.571N     P=0.500      (e)          (e)         |P=0.201N     P=0.309      P=0.747      P=0.500N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/6 (17%)    1/13 (8%)    0/8 (0%)     2/8 (25%)   |0/3 (0%)     0/6 (0%)     1/7 (14%)    0/6 (0%)     |
|POLY-3 ADJUSTED (b)|     16.7%        7.7%         0.0%         26.2%       |0.0%         0.0%         14.3%        0.0%         |
|TERMINAL (d)       |     1/6 (17%)    1/13 (8%)    0/8 (0%)     2/7 (29%)   |0/3 (0%)     0/6 (0%)     1/7 (14%)    0/6 (0%)     |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          729 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.307      P=0.582N     P=0.443N     P=0.558     |P=0.765      (e)          P=0.669      (e)          |
|POLY 3             |     P=0.340      P=0.580N     P=0.442N     P=0.588     |P=0.760      (e)          P=0.663      (e)          |
|POLY 1.5           |     P=0.344      P=0.580N     P=0.442N     P=0.595     |P=0.760      (e)          P=0.663      (e)          |
|POLY 6             |     P=0.334      P=0.580N     P=0.442N     P=0.577     |P=0.760      (e)          P=0.663      (e)          |
|LOGISTIC REGRESSION|     P=0.307      P=0.582N     (e)          P=0.558     |(e)          (e)          P=0.669      (e)          |
|COCH-ARM / FISHERS |     P=0.346      P=0.544N     P=0.429N     P=0.615     |P=0.771      (e)          P=0.700      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth: Peridontal Tissue                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/6 (83%)    13/13 (100%) 8/8 (100%)   6/8 (75%)   |3/3 (100%)   6/6 (100%)   6/7 (86%)    6/6 (100%)   |
|POLY-3 ADJUSTED (b)|     83.3%        100.0%       100.0%       75.0%       |100.0%       100.0%       85.7%        100.0%       |
|TERMINAL (d)       |     5/6 (83%)    13/13 (100%) 8/8 (100%)   5/7 (71%)   |3/3 (100%)   6/6 (100%)   6/7 (86%)    6/6 (100%)   |
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      625         |729 (T)      729 (T)      729 (T)      729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.547N     P=0.346      P=0.443      P=0.653     |P=0.765      (e)          P=0.669N     (e)          |
|POLY 3             |     P=0.215N     P=0.341      P=0.442      P=0.604N    |P=0.760      (e)          P=0.663N     (e)          |
|POLY 1.5           |     P=0.215N     P=0.341      P=0.442      P=0.604N    |P=0.760      (e)          P=0.663N     (e)          |
|POLY 6             |     P=0.215N     P=0.341      P=0.442      P=0.604N    |P=0.760      (e)          P=0.663N     (e)          |
|LOGISTIC REGRESSION|     P=0.547N     P=0.346      P=0.443      (e)         |P=0.765      (e)          P=0.669N     (e)          |
|COCH-ARM / FISHERS |     P=0.219N     P=0.316      P=0.429      P=0.615N    |P=0.771      (e)          P=0.700N     (e)          |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|                                                        |2.0%         0.0%         8.4%         6.1%         |
|TERMINAL (d)       |                                                        |1/46 (2%)    0/47 (0%)    3/43 (7%)    3/49 (6%)    |
|FIRST INCIDENCE    |                                                        |729 (T)      ---          716          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.127      P=0.496N     P=0.164      P=0.328      |
|POLY 3             |                                                        |P=0.111      P=0.501N     P=0.171      P=0.305      |
|POLY 1.5           |                                                        |P=0.109      P=0.501N     P=0.174      P=0.304      |
|POLY 6             |                                                        |P=0.114      P=0.500N     P=0.169      P=0.310      |
|LOGISTIC REGRESSION|                                                        |P=0.116      (e)          P=0.167      P=0.328      |
|COCH-ARM / FISHERS |                                                        |P=0.111      P=0.500N     P=0.181      P=0.309      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hemorrhage                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|                                                        |4.0%         0.0%         0.0%         2.0%         |
|TERMINAL (d)       |                                                        |1/46 (2%)    0/47 (0%)    0/43 (0%)    1/49 (2%)    |
|FIRST INCIDENCE    |                                                        |629          ---          ---          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.455N     P=0.240N     P=0.254N     P=0.488N     |
|POLY 3             |                                                        |P=0.461N     P=0.240N     P=0.245N     P=0.503N     |
|POLY 1.5           |                                                        |P=0.461N     P=0.239N     P=0.242N     P=0.503N     |
|POLY 6             |                                                        |P=0.462N     P=0.241N     P=0.249N     P=0.500N     |
|LOGISTIC REGRESSION|                                                        |P=0.428N     P=0.163N     P=0.156N     P=0.468N     |
|COCH-ARM / FISHERS |                                                        |P=0.461N     P=0.247N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/08/00                           EXPERIMENT: 05205 TEST: 08                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   P-NITROTOLUENE
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |19/50 (38%)  21/50 (42%)  23/50 (46%)  25/50 (50%)  |
|POLY-3 ADJUSTED (b)|                                                        |38.7%        42.2%        48.0%        51.0%        |
|TERMINAL (d)       |                                                        |19/46 (41%)  19/47 (40%)  22/43 (51%)  25/49 (51%)  |
|FIRST INCIDENCE    |                                                        |729 (T)      487          682          729 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.182      P=0.453      P=0.181      P=0.230      |
|POLY 3             |                                                        |P=0.115      P=0.441      P=0.236      P=0.154      |
|POLY 1.5           |                                                        |P=0.114      P=0.431      P=0.249      P=0.150      |
|POLY 6             |                                                        |P=0.122      P=0.456      P=0.226      P=0.167      |
|LOGISTIC REGRESSION|                                                        |P=0.120      P=0.425      P=0.207      P=0.230      |
|COCH-ARM / FISHERS |                                                        |P=0.124      P=0.419      P=0.272      P=0.157      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0            1250         2500         5000        |0            1250         2500         5000         |
|                   |     PPM          PPM          PPM          PPM         |PPM          PPM          PPM          PPM          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus: Endometrium                                                                                                              |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |47/50 (94%)  45/50 (90%)  44/50 (88%)  49/50 (98%)  |
|POLY-3 ADJUSTED (b)|                                                        |94.7%        92.1%        90.5%        98.0%        |
|TERMINAL (d)       |                                                        |44/46 (96%)  45/47 (96%)  41/43 (95%)  48/49 (98%)  |
|FIRST INCIDENCE    |                                                        |654          729 (T)      534          276          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.562      P=0.229N     P=0.620N     P=0.510N     |
|POLY 3             |                                                        |P=0.250      P=0.453N     P=0.332N     P=0.360      |
|POLY 1.5           |                                                        |P=0.233      P=0.413N     P=0.294N     P=0.334      |
|POLY 6             |                                                        |P=0.281      P=0.505N     P=0.380N     P=0.403      |
|LOGISTIC REGRESSION|                                                        |P=0.133      P=0.316N     P=0.438N     P=0.281      |
|COCH-ARM / FISHERS |                                                        |P=0.220      P=0.357N     P=0.243N     P=0.309      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).