TDMS Study 05210-03 Pathology Tables
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
CORE STUDY
Facility: I. I. T. Research Institute
Chemical CAS #: 100-41-4
Lock Date: 10/02/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 14 8 6
Natural Death 12 5 8 8
Survivors
Terminal Sacrifice 30 31 34 35
Natural Death 1
Missing 1
Animals Examined Microscopically 50 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (49) (48) (49)
Inflammation 1 (2%)
Intestine Large, Rectum (49) (50) (47) (49)
Arteriole, Inflammation 1 (2%)
Intestine Large, Cecum (44) (50) (47) (49)
Inflammation 1 (2%)
Intestine Small, Ileum (41) (48) (47) (46)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Liver (50) (50) (50) (49)
Angiectasis 3 (6%) 6 (12%)
Basophilic Focus 23 (46%) 29 (58%) 33 (66%) 29 (59%)
Clear Cell Focus 3 (6%) 3 (6%) 1 (2%) 4 (8%)
Congestion 1 (2%) 1 (2%) 1 (2%)
Degeneration 1 (2%) 2 (4%)
Eosinophilic Focus 2 (4%) 3 (6%) 8 (16%) 5 (10%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 4 (8%) 4 (8%) 5 (10%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Mixed Cell Focus 5 (10%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Vacuolization Cytoplasmic 11 (22%) 12 (24%) 14 (28%) 14 (29%)
Centrilobular, Degeneration 1 (2%)
Portal Vein, Thrombosis 1 (2%)
Mesentery (7) (4) (6) (7)
Artery, Degeneration 1 (17%)
Artery, Inflammation 1 (14%) 1 (17%)
Fat, Necrosis 6 (86%) 4 (100%) 5 (83%) 7 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (49) (50) (50) (49)
Cyst 1 (2%)
Inflammation 2 (4%)
Acinus, Atrophy 18 (37%) 18 (36%) 18 (36%) 19 (39%)
Arteriole, Inflammation 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (50) (49)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%) 1 (2%)
Hyperplasia 3 (6%) 1 (2%) 3 (6%) 8 (16%)
Inflammation 1 (2%) 1 (2%) 6 (12%)
Ulcer 3 (6%) 4 (8%) 1 (2%)
Stomach, Glandular (49) (49) (49) (49)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation 2 (4%)
Necrosis 5 (10%) 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Ulcer 4 (8%) 1 (2%)
Glands, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50) (49)
Degeneration 1 (2%)
Inflammation 1 (2%)
Aorta, Inflammation 1 (2%)
Heart (50) (50) (50) (49)
Cardiomyopathy 6 (12%) 1 (2%) 6 (12%)
Fibrosis 1 (2%)
Inflammation 1 (2%)
Atrium, Inflammation 1 (2%)
Atrium, Thrombosis 1 (2%)
Endocardium, Hyperplasia 1 (2%) 1 (2%)
Myocardium, Hypertrophy 1 (2%)
Valve, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (49)
Angiectasis 3 (6%) 3 (6%) 4 (8%) 3 (6%)
Cytoplasmic Alteration 1 (2%) 3 (6%) 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 5 (10%) 3 (6%) 2 (4%) 4 (8%)
Hemorrhage 4 (8%) 5 (10%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 3 (6%) 4 (8%) 2 (4%) 3 (6%)
Hypertrophy 3 (6%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 12 (24%) 5 (10%) 12 (24%) 6 (12%)
Adrenal Medulla (50) (50) (50) (49)
Hemorrhage 1 (2%)
Hyperplasia 4 (8%) 2 (4%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Necrosis 1 (2%)
Parathyroid Gland (48) (46) (42) (47)
Atrophy 1 (2%)
Hyperplasia 5 (10%) 2 (4%) 4 (10%) 5 (11%)
Pituitary Gland (49) (49) (50) (49)
Cyst 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 16 (33%) 6 (12%) 2 (4%)
Pars Distalis, Cyst 5 (10%) 1 (2%) 3 (6%) 3 (6%)
Pars Distalis, Degeneration 1 (2%)
Pars Distalis, Hemorrhage 2 (4%)
Pars Distalis, Hyperplasia 11 (22%) 9 (18%) 14 (28%) 17 (35%)
Pars Distalis, Pigmentation 2 (4%)
Pars Intermedia, Angiectasis 2 (4%)
Thyroid Gland (48) (50) (50) (49)
Hyperplasia 1 (2%)
Inflammation 1 (2%)
Bilateral, C-Cell, Hyperplasia 1 (2%)
C-Cell, Hyperplasia 5 (10%) 5 (10%) 5 (10%) 5 (10%)
C-Cell, Inflammation 1 (2%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (49) (48) (47)
Cyst 1 (2%)
Hyperplasia 4 (9%) 3 (6%) 1 (2%) 3 (6%)
Inflammation 6 (13%) 5 (10%) 4 (8%) 4 (9%)
Bilateral, Hyperplasia 1 (2%)
Ovary (50) (50) (50) (49)
Cyst 5 (10%) 6 (12%) 5 (10%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Corpus Luteum, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (49)
Angiectasis 1 (2%)
Hydrometra 1 (2%) 3 (6%) 1 (2%) 4 (8%)
Inflammation 1 (2%) 1 (2%)
Endometrium, Cyst 1 (2%)
Vagina (3)
Fibrosis 1 (33%)
Arteriole, Degeneration 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (49)
Atrophy 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 2 (4%) 1 (2%)
Hyperplasia 7 (14%) 8 (16%) 7 (14%) 8 (16%)
Hyperplasia, Mast Cell 1 (2%)
Myelofibrosis 1 (2%)
Myelostromal Proliferation 1 (2%) 1 (2%)
Erythroid Cell, Hyperplasia 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%) 1 (2%)
Lymph Node (3) (3) (4) (4)
Pancreatic, Hemorrhage 1 (25%) 1 (25%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (25%)
Renal, Hemorrhage 2 (50%)
Renal, Pigmentation 1 (25%)
Lymph Node, Bronchial (37) (34) (41) (38)
Atrophy 1 (3%)
Ectasia 1 (2%)
Hemorrhage 4 (11%) 6 (18%) 5 (12%) 3 (8%)
Hyperplasia, Lymphoid 1 (3%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
Pigmentation 6 (16%) 7 (21%) 7 (17%) 5 (13%)
Lymph Node, Mandibular (49) (50) (50) (49)
Ectasia 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Hyperplasia, Plasma Cell 2 (4%) 9 (18%) 4 (8%) 3 (6%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (49)
Amyloid Deposition 1 (2%)
Atrophy 1 (2%)
Ectasia 3 (6%)
Hemorrhage 8 (16%) 6 (12%) 8 (16%) 7 (14%)
Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation 1 (2%) 1 (2%)
Lymph Node, Mediastinal (49) (49) (50) (49)
Edema 1 (2%)
Hemorrhage 21 (43%) 15 (31%) 13 (26%) 21 (43%)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
Pigmentation 22 (45%) 22 (45%) 25 (50%) 27 (55%)
Spleen (49) (50) (49) (49)
Hematopoietic Cell Proliferation 6 (12%) 3 (6%) 3 (6%) 3 (6%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Red Pulp, Atrophy 1 (2%)
Thymus (48) (47) (47) (47)
Atrophy 1 (2%)
Cyst 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (49) (49)
Galactocele 10 (21%) 10 (20%) 10 (20%) 11 (22%)
Hyperplasia 13 (27%) 19 (38%) 21 (43%) 18 (37%)
Infiltration Cellular, Lymphocyte 1 (2%)
Skin (50) (50) (50) (49)
Cyst Epithelial Inclusion 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Epidermis, Hyperplasia 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
Fibrous Osteodystrophy 1 (2%)
Hyperostosis 2 (4%) 5 (10%) 5 (10%) 1 (2%)
Turbinate, Hyperostosis 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (45) (43) (44) (45)
Infiltration Cellular, Lymphocyte 3 (7%) 1 (2%)
Inflammation 2 (5%) 1 (2%) 2 (4%)
Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 2 (4%)
Lung (50) (50) (50) (49)
Congestion 5 (10%) 1 (2%)
Edema 1 (2%) 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 2 (4%)
Infiltration Cellular, Histiocyte 2 (4%) 3 (6%) 1 (2%) 3 (6%)
Inflammation, Chronic 2 (4%) 3 (6%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (10%) 2 (4%) 5 (10%)
Nose (50) (50) (50) (49)
Angiectasis 1 (2%)
Congestion 1 (2%)
Foreign Body 4 (8%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 10 (20%) 10 (20%) 5 (10%) 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Glands, Cyst 1 (2%)
Glands, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Goblet Cell, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation 2 (4%) 1 (2%)
Nasolacrimal Duct, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 6 (12%) 7 (14%) 5 (10%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Ulcer 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3) (1)
Lens, Cataract 1 (100%) 2 (67%) 1 (100%)
Retina, Degeneration 1 (100%) 1 (100%)
Harderian Gland (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Cyst 1 (2%) 1 (2%) 4 (8%)
Infarct 1 (2%) 1 (2%)
Mineralization 8 (16%) 11 (22%) 7 (14%)
Necrosis 1 (2%)
Nephropathy 38 (76%) 42 (84%) 43 (86%) 46 (94%)
Pigmentation 4 (8%) 10 (20%) 8 (16%) 3 (6%)
Arteriole, Inflammation 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 3 (6%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 16 11 22
Moribund Sacrifice 28 20 26 26
Survivors
Terminal Sacrifice 15 14 13 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (48) (48) (48)
Hemorrhage 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (49) (48) (48)
Thrombosis 1 (2%)
Intestine Large, Cecum (46) (44) (46) (39)
Inflammation 1 (2%) 2 (5%) 1 (3%)
Mineralization 1 (3%)
Necrosis 1 (2%)
Ulcer 1 (2%)
Intestine Small, Duodenum (48) (48) (50) (50)
Mineralization 1 (2%)
Necrosis 1 (2%)
Intestine Small, Jejunum (42) (39) (44) (34)
Inflammation 1 (3%)
Intestine Small, Ileum (45) (44) (45) (37)
Inflammation 1 (3%)
Liver (50) (50) (50) (49)
Angiectasis 2 (4%) 1 (2%)
Basophilic Focus 6 (12%) 5 (10%) 2 (4%) 4 (8%)
Clear Cell Focus 2 (4%) 3 (6%) 3 (6%)
Cyst 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 15 (30%) 12 (24%) 19 (38%) 30 (61%)
Eosinophilic Focus 5 (10%) 11 (22%) 4 (8%) 9 (18%)
Fibrosis 3 (6%)
Hemorrhage 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%)
Necrosis 2 (4%) 4 (8%) 8 (16%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 8 (16%) 10 (20%) 7 (14%) 4 (8%)
Bile Duct, Hyperplasia 1 (2%)
Bile Duct, Inflammation, Suppurative 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%)
Mesentery (4) (5) (3) (3)
Inflammation 1 (20%)
Fat, Necrosis 3 (75%) 4 (80%) 2 (67%) 3 (100%)
Pancreas (50) (49) (50) (50)
Inflammation 2 (4%) 1 (2%) 1 (2%)
Acinus, Atrophy 24 (48%) 21 (43%) 20 (40%) 18 (36%)
Acinus, Hyperplasia 4 (8%) 1 (2%)
Artery, Degeneration 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia 8 (16%) 5 (10%) 8 (16%) 8 (16%)
Inflammation 1 (2%) 1 (2%) 3 (6%) 3 (6%)
Mineralization 2 (4%) 1 (2%) 1 (2%) 5 (10%)
Ulcer 9 (18%) 9 (18%) 9 (18%) 10 (20%)
Stomach, Glandular (50) (49) (50) (50)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%)
Inflammation 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Mineralization 4 (8%) 4 (8%) 3 (6%) 18 (36%)
Necrosis 5 (10%) 2 (4%) 2 (4%)
Ulcer 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Mineralization 1 (2%)
Aorta, Inflammation 1 (2%) 1 (2%)
Aorta, Mineralization 2 (4%) 2 (4%) 4 (8%) 14 (28%)
Heart (50) (50) (50) (50)
Cardiomyopathy 26 (52%) 21 (42%) 15 (30%) 30 (60%)
Inflammation 1 (2%)
Mineralization 2 (4%) 1 (2%) 7 (14%)
Atrium, Thrombosis 5 (10%) 7 (14%) 7 (14%)
Valve, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Cytoplasmic Alteration 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Hypertrophy 1 (2%)
Necrosis 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Vacuolization Cytoplasmic 13 (26%) 18 (36%) 16 (32%) 11 (22%)
Bilateral, Atrophy 1 (2%)
Capsule, Inflammation 1 (2%)
Adrenal Medulla (50) (50) (49) (48)
Hyperplasia 10 (20%) 7 (14%) 13 (27%) 8 (17%)
Necrosis 1 (2%)
Bilateral, Hyperplasia 2 (4%) 2 (4%) 1 (2%) 4 (8%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%) 5 (10%) 4 (8%)
Parathyroid Gland (45) (46) (46) (46)
Fibrosis 1 (2%)
Hyperplasia 12 (27%) 6 (13%) 16 (35%) 35 (76%)
Pituitary Gland (49) (50) (50) (45)
Pars Distalis, Angiectasis 5 (10%) 11 (22%) 5 (10%) 4 (9%)
Pars Distalis, Cyst 1 (2%) 6 (12%) 5 (10%) 4 (9%)
Pars Distalis, Degeneration 1 (2%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 12 (24%) 11 (22%) 12 (24%) 12 (27%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation 1 (2%) 2 (4%)
Pars Intermedia, Angiectasis 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Cyst 1 (2%)
C-Cell, Hyperplasia 6 (12%) 5 (10%) 5 (10%)
Follicle, Cyst 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Preputial Gland (49) (50) (49) (50)
Atrophy 1 (2%)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Inflammation 19 (39%) 7 (14%) 8 (16%) 10 (20%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 11 (22%) 29 (58%) 22 (44%) 25 (50%)
Seminal Vesicle (49) (49) (50) (50)
Inflammation 1 (2%) 1 (2%)
Mineralization 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 10 (20%) 7 (14%) 10 (20%) 6 (12%)
Degeneration 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Mineralization 2 (4%)
Arteriole, Inflammation 1 (2%) 1 (2%)
Bilateral, Atrophy 9 (18%) 7 (14%) 5 (10%) 4 (8%)
Bilateral, Necrosis 1 (2%)
Interstitial Cell, Hyperplasia 14 (28%) 19 (38%) 12 (24%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (50) (50)
Atrophy 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 4 (8%)
Hyperplasia 7 (14%) 16 (33%) 9 (18%) 19 (38%)
Inflammation 1 (2%)
Myelofibrosis 3 (6%) 5 (10%)
Myeloid Cell, Atrophy 1 (2%)
Lymph Node (9) (8) (9) (14)
Hemorrhage 1 (11%)
Lumbar, Hemorrhage 1 (13%)
Lumbar, Hyperplasia, Plasma Cell 1 (13%)
Pancreatic, Fibrosis 1 (11%)
Pancreatic, Pigmentation 1 (11%)
Renal, Ectasia 2 (22%) 1 (7%)
Renal, Hemorrhage 1 (11%) 8 (57%)
Renal, Hyperplasia, Lymphoid 1 (7%)
Renal, Hyperplasia, Plasma Cell 1 (11%) 1 (7%)
Renal, Infiltration Cellular, Histiocyte 1 (13%)
Renal, Pigmentation 1 (11%) 2 (14%)
Lymph Node, Bronchial (44) (34) (39) (28)
Ectasia 1 (3%)
Hemorrhage 7 (16%) 4 (12%) 4 (10%) 7 (25%)
Infiltration Cellular, Histiocyte 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation 3 (7%) 3 (9%) 5 (18%)
Lymph Node, Mandibular (47) (48) (49) (50)
Atrophy 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 4 (9%) 1 (2%) 1 (2%) 4 (8%)
Inflammation 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Atrophy 1 (2%)
Ectasia 1 (2%)
Hemorrhage 3 (6%) 5 (10%) 4 (8%) 8 (16%)
Inflammation 1 (2%) 1 (2%)
Lymph Node, Mediastinal (48) (48) (50) (47)
Edema 1 (2%) 1 (2%) 3 (6%)
Hemorrhage 12 (25%) 10 (21%) 10 (20%) 17 (36%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 1 (2%)
Inflammation 1 (2%)
Pigmentation 9 (19%) 8 (17%) 7 (14%) 7 (15%)
Spleen (50) (49) (50) (50)
Atrophy 2 (4%)
Congestion 1 (2%) 1 (2%)
Depletion Cellular 2 (4%) 3 (6%) 4 (8%)
Fibrosis 3 (6%) 1 (2%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Necrosis 2 (4%) 2 (4%)
Pigmentation 1 (2%)
Red Pulp, Depletion Cellular 1 (2%)
Thymus (46) (44) (46) (44)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (47) (46) (49)
Fibrosis 1 (2%)
Galactocele 11 (24%) 11 (23%) 11 (24%) 9 (18%)
Hyperplasia 3 (7%) 3 (6%) 4 (9%) 3 (6%)
Inflammation 1 (2%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Pigmentation 1 (2%) 4 (9%) 2 (4%) 6 (12%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 4 (8%) 2 (4%)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Granulomatous 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Subcutaneous Tissue, Inflammation 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%) 5 (10%) 9 (18%)
Hyperostosis 2 (4%)
Turbinate, Hyperostosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Necrosis 2 (4%) 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (40) (44) (41) (35)
Foreign Body 1 (2%)
Infiltration Cellular, Lymphocyte 1 (3%) 1 (2%) 1 (2%) 1 (3%)
Inflammation 1 (3%) 3 (7%) 3 (7%) 1 (3%)
Necrosis 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (3%) 4 (9%) 1 (2%) 1 (3%)
Respiratory Epithelium, Metaplasia, Squamous 1 (3%) 1 (2%) 1 (2%) 2 (6%)
Lung (50) (50) (50) (50)
Congestion 1 (2%) 2 (4%) 6 (12%)
Edema 1 (2%) 6 (12%)
Fibrosis 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 8 (16%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 3 (6%) 2 (4%) 7 (14%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 3 (6%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Artery, Mineralization 1 (2%)
Goblet Cell, Hyperplasia 1 (2%)
Interstitium, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Interstitium, Inflammation 1 (2%)
Nose (49) (49) (50) (50)
Angiectasis 1 (2%)
Congestion 1 (2%)
Foreign Body 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 8 (16%) 8 (16%) 9 (18%) 9 (18%)
Necrosis 1 (2%)
Glands, Cyst 1 (2%)
Goblet Cell, Hyperplasia 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%) 1 (2%) 1 (2%)
Olfactory Epithelium, Inflammation 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Hyperplasia 9 (18%) 7 (14%) 9 (18%) 6 (12%)
Respiratory Epithelium, Inflammation 1 (2%) 3 (6%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
Respiratory Epithelium, Ulcer 1 (2%) 1 (2%)
Trachea (50) (50) (50) (50)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Lens, Cataract 1 (100%)
Retina, Degeneration 1 (100%)
Zymbal's Gland (1) (1) (1)
Cyst 1 (100%)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 4 (8%) 1 (2%) 10 (20%)
Hemorrhage 1 (2%)
Infarct 2 (4%) 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%) 9 (18%)
Necrosis 1 (2%) 1 (2%)
Nephropathy 47 (94%) 43 (86%) 47 (94%) 48 (96%)
Pigmentation 9 (18%) 6 (12%) 9 (18%) 2 (4%)
Renal Tubule, Hyperplasia 2 (4%) 2 (4%) 4 (8%) 12 (24%)
Transitional Epithelium, Hyperplasia 12 (24%) 14 (28%) 15 (30%) 34 (68%)
Urinary Bladder (49) (49) (50) (49)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Inflammation 1 (2%) 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05210-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLBENZENE Date: 03/14/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:45:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 75 PPM 250 750
PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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