Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/3645

TDMS Study 05210-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: I. I. T. Research Inst                                   ETHYLBENZENE                                     DATE: 03/14/96       
EXPERIMENT: 05210 TEST: 03                                                                                     TIME: 12:05:20       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-75193                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56393        
PATHOLOGIST: BRENNECKE, LUK                                                                                    CAS: 100-41-4        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: I. I. T. Research Inst                                   ETHYLBENZENE                                     DATE: 03/14/96       
EXPERIMENT: 05210 TEST: 03                                                                                     TIME: 12:05:20       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-75193                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56393        
PATHOLOGIST: BRENNECKE, LUK                                                                                    CAS: 100-41-4        


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: I. I. T. Research Inst                                   ETHYLBENZENE                                     DATE: 03/14/96       
EXPERIMENT: 05210 TEST: 03                                                                                     TIME: 12:05:20       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-75193                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 56393        
PATHOLOGIST: BRENNECKE, LUK                                                                                    CAS: 100-41-4        


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF ETHYLBENZENE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Clitoral/Preputial Gland      Adenoma
                                            Carcinoma or Adenoma
              Islets, Pancreatic            Adenoma
              Kidney: Renal Tubule          Adenoma
                                            Carcinoma
                                            Carcinoma or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
                                            Carcinoma or Adenoma
              Testes                        Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              All Organs                    Malignant Tumors
              ====================================================================================================
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  13/50 (26%)   9/49 (18%)  12/48 (25%) |  2/50 (4%)    2/50 (4%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  48.8%        62.0%        42.6%       100.0%      |   6.5%         5.6%         0.0%         0.0%      |
|TERMINAL (d)           |  4/15 (27%)   7/14 (50%)   4/13 (31%)   2/2 (100%) |  2/31 (6%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   584          584          590          546       |   734 (T)      719          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.003 **   P=0.545      P=0.279N     P=0.014 *  |  P=0.112N     P=0.677N     P=0.218N     P=0.212N   |
|INCIDENTAL TUMOR       |  P=0.296      P=0.514      P=0.233N     P=0.447    |  P=0.116N     P=0.658      P=0.218N     P=0.212N   |
|LOGISTIC REGRESSION    |  P=0.211      P=0.552      P=0.233N     P=0.307    |  P=0.108N     P=0.686N     P=0.218N     P=0.212N   |
|COCHRAN-ARMITAGE       |  P=0.516N                                          |  P=0.124N                                          |
|FISHER EXACT           |               P=0.590N     P=0.251N     P=0.547N   |               P=0.691N     P=0.247N     P=0.253N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    0/49 (0%)    2/48 (4%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         7.1%         0.0%         5.2%      |   0.0%         3.2%         5.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    1/14 (7%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    1/31 (3%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          734 (T)      ---          507       |   ---          734 (T)      659          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.060      P=0.486        (e)        P=0.216    |  P=0.480N     P=0.500      P=0.254        (e)      |
|INCIDENTAL TUMOR       |  P=0.144      P=0.486        (e)        P=0.361    |  P=0.506N     P=0.500      P=0.213        (e)      |
|LOGISTIC REGRESSION    |  P=0.161      P=0.486        (e)        P=0.290    |  P=0.514N     P=0.500      P=0.234        (e)      |
|COCHRAN-ARMITAGE       |  P=0.143                                           |  P=0.521N                                          |
|FISHER EXACT           |               P=0.500        (e)        P=0.237    |               P=0.500      P=0.247        (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)  13/50 (26%)   9/49 (18%)  14/48 (29%) |  2/50 (4%)    3/50 (6%)    2/50 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |  48.8%        62.0%        42.6%       100.0%      |   6.5%         8.6%         5.0%         0.0%      |
|TERMINAL (d)           |  4/15 (27%)   7/14 (50%)   4/13 (31%)   2/2 (100%) |  2/31 (6%)    1/31 (3%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   584          584          590          507       |   734 (T)      719          659          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.545      P=0.279N     P=0.005 ** |  P=0.101N     P=0.516      P=0.664N     P=0.212N   |
|INCIDENTAL TUMOR       |  P=0.152      P=0.514      P=0.233N     P=0.312    |  P=0.108N     P=0.464      P=0.694      P=0.212N   |
|LOGISTIC REGRESSION    |  P=0.106      P=0.552      P=0.233N     P=0.214    |  P=0.105N     P=0.514      P=0.678N     P=0.212N   |
|COCHRAN-ARMITAGE       |  P=0.379                                           |  P=0.120N                                          |
|FISHER EXACT           |               P=0.590N     P=0.251N     P=0.450    |               P=0.500      P=0.691N     P=0.253N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/49 (6%)    1/50 (2%)    1/49 (2%)    4/50 (8%)  |  2/47 (4%)    0/49 (0%)    0/48 (0%)    0/47 (0%)  |
|ADJUSTED (b)           |  12.5%         2.3%         7.7%        42.7%      |   6.9%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/14 (7%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  2/29 (7%)    0/30 (0%)    0/32 (0%)    0/34 (0%)  |
|FIRST INCIDENCE (DAYS) |   574          560          734 (T)      500       |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.048 *    P=0.318N     P=0.314N     P=0.172    |  P=0.221N     P=0.230N     P=0.216N     P=0.204N   |
|INCIDENTAL TUMOR       |  P=0.260      P=0.300N     P=0.328N     P=0.566    |  P=0.221N     P=0.230N     P=0.216N     P=0.204N   |
|LOGISTIC REGRESSION    |  P=0.228      P=0.291N     P=0.302N     P=0.502    |  P=0.221N     P=0.230N     P=0.216N     P=0.204N   |
|COCHRAN-ARMITAGE       |  P=0.227                                           |  P=0.244N                                          |
|FISHER EXACT           |               P=0.301N     P=0.309N     P=0.511    |               P=0.237N     P=0.242N     P=0.247N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/49 (6%)    1/50 (2%)    1/49 (2%)    4/50 (8%)  |  3/47 (6%)    0/49 (0%)    1/48 (2%)    0/47 (0%)  |
|ADJUSTED (b)           |  12.5%         2.3%         7.7%        42.7%      |  10.3%         0.0%         3.1%         0.0%      |
|TERMINAL (d)           |  1/14 (7%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  3/29 (10%)   0/30 (0%)    1/32 (3%)    0/34 (0%)  |
|FIRST INCIDENCE (DAYS) |   574          560          734 (T)      500       |   734 (T)      ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.048 *    P=0.318N     P=0.314N     P=0.172    |  P=0.137N     P=0.114N     P=0.269N     P=0.094N   |
|INCIDENTAL TUMOR       |  P=0.260      P=0.300N     P=0.328N     P=0.566    |  P=0.137N     P=0.114N     P=0.269N     P=0.094N   |
|LOGISTIC REGRESSION    |  P=0.228      P=0.291N     P=0.302N     P=0.502    |  P=0.137N     P=0.114N     P=0.268N     P=0.094N   |
|COCHRAN-ARMITAGE       |  P=0.227                                           |  P=0.162N                                          |
|FISHER EXACT           |               P=0.301N     P=0.309N     P=0.511    |               P=0.113N     P=0.301N     P=0.121N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    4/50 (8%)    4/50 (8%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |  16.0%        17.5%        22.5%        60.5%      |   3.2%         0.0%         2.8%         2.3%      |
|TERMINAL (d)           |  1/15 (7%)    1/14 (7%)    2/13 (15%)   1/2 (50%)  |  1/31 (3%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   692          560          671          645       |   734 (T)      ---          699          655       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.033 *    P=0.492      P=0.477      P=0.043 *  |  P=0.580      P=0.500N     P=0.744N     P=0.736N   |
|INCIDENTAL TUMOR       |  P=0.323      P=0.472      P=0.545      P=0.298    |  P=0.552      P=0.500N     P=0.760      P=0.758N   |
|LOGISTIC REGRESSION    |  P=0.220      P=0.483      P=0.509      P=0.163    |  P=0.546      P=0.500N     P=0.750N     P=0.763N   |
|COCHRAN-ARMITAGE       |  P=0.493                                           |  P=0.539                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.500    |               P=0.500N     P=0.753N     P=0.747    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   8.6%         7.1%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    1/14 (7%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   590          734 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.308N     P=0.504N     P=0.244N     P=0.449N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.189N     P=0.512N     P=0.242N     P=0.187N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.201N     P=0.510N     P=0.238N     P=0.267N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.169N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.247N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   5/50 (10%)   4/50 (8%)    4/50 (8%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |  23.3%        23.9%        22.5%        60.5%      |   3.2%         0.0%         2.8%         2.3%      |
|TERMINAL (d)           |  1/15 (7%)    2/14 (14%)   2/13 (15%)   1/2 (50%)  |  1/31 (3%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   590          560          671          645       |   734 (T)      ---          699          655       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.116      P=0.617      P=0.523N     P=0.152    |  P=0.580      P=0.500N     P=0.744N     P=0.736N   |
|INCIDENTAL TUMOR       |  P=0.581      P=0.600      P=0.462N     P=0.643N   |  P=0.552      P=0.500N     P=0.760      P=0.758N   |
|LOGISTIC REGRESSION    |  P=0.464      P=0.612      P=0.492N     P=0.462    |  P=0.546      P=0.500N     P=0.750N     P=0.763N   |
|COCHRAN-ARMITAGE       |  P=0.429N                                          |  P=0.539                                           |
|FISHER EXACT           |               P=0.630N     P=0.500N     P=0.500N   |               P=0.500N     P=0.753N     P=0.747    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    2/50 (4%)    4/50 (8%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   0.0%        11.2%        11.0%        56.9%      |   0.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    1/13 (8%)    1/2 (50%)  |  0/31 (0%)    0/31 (0%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          617          671          587       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.006 **   P=0.120      P=0.236      P=0.008 ** |  P=0.232        (e)          (e)        P=0.524    |
|INCIDENTAL TUMOR       |  P=0.095      P=0.126      P=0.251      P=0.033 *  |  P=0.232        (e)          (e)        P=0.524    |
|LOGISTIC REGRESSION    |  P=0.064      P=0.119      P=0.240      P=0.037 *  |  P=0.232        (e)          (e)        P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.109                                           |  P=0.210                                           |
|FISHER EXACT           |               P=0.121      P=0.247      P=0.059    |                 (e)          (e)        P=0.495    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         7.7%        12.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          734 (T)      587       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.002 **     (e)        P=0.471      P=0.063    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.016 *      (e)        P=0.471      P=0.177    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.018 *      (e)        P=0.471      P=0.129    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.021 *                                         |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.500      P=0.121    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    3/50 (6%)    7/50 (14%) |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   0.0%        11.2%        18.4%        62.4%      |   0.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    2/13 (15%)   1/2 (50%)  |  0/31 (0%)    0/31 (0%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          617          671          587       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.120      P=0.111      P<0.001 ** |  P=0.232        (e)          (e)        P=0.524    |
|INCIDENTAL TUMOR       |  P=0.005 **   P=0.126      P=0.118      P=0.007 ** |  P=0.232        (e)          (e)        P=0.524    |
|LOGISTIC REGRESSION    |  P=0.003 **   P=0.119      P=0.121      P=0.006 ** |  P=0.232        (e)          (e)        P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.007 **                                        |  P=0.210                                           |
|FISHER EXACT           |               P=0.121      P=0.121      P=0.006 ** |                 (e)          (e)        P=0.495    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         9.7%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          560          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.326N     P=0.112        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.208N     P=0.126        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.125        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.259N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.121        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    1/50 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |  12.2%         5.3%         0.0%        10.0%      |   3.2%         3.2%         2.9%         0.0%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  1/31 (3%)    1/31 (3%)    1/34 (3%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          713          ---          679       |   734 (T)      734 (T)      734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.521      P=0.495N     P=0.270N     P=0.532    |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.555N     P=0.544N     P=0.227N     P=0.660N   |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.664      P=0.511N     P=0.236N     P=0.688    |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.327N                                          |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.500N   |               P=0.753N     P=0.753N     P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |  1/50 (2%)    1/50 (2%)    1/50 (2%)    0/49 (0%)  |
|ADJUSTED (b)           |  18.4%         5.3%         0.0%        10.0%      |   3.2%         3.2%         2.9%         0.0%      |
|TERMINAL (d)           |  2/15 (13%)   0/14 (0%)    0/13 (0%)    0/2 (0%)   |  1/31 (3%)    1/31 (3%)    1/34 (3%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   714          713          ---          679       |   734 (T)      734 (T)      734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.643      P=0.309N     P=0.146N     P=0.593    |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.458N     P=0.346N     P=0.122N     P=0.595N   |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.635N     P=0.310N     P=0.119N     P=0.740N   |  P=0.295N     P=0.762      P=0.741N     P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.339N                                          |  P=0.327N                                          |
|FISHER EXACT           |               P=0.309N     P=0.121N     P=0.309N   |               P=0.753N     P=0.753N     P=0.505N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.0%         0.0%      |   2.4%         6.5%         0.0%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    2/31 (6%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          643          ---       |   651          734 (T)      ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.807        (e)        P=0.519        (e)      |  P=0.515N     P=0.488      P=0.491N     P=0.742N   |
|INCIDENTAL TUMOR       |  P=0.721N       (e)        P=0.443        (e)      |  P=0.523N     P=0.477      P=0.519N     P=0.758N   |
|LOGISTIC REGRESSION    |  P=0.796N       (e)        P=0.500        (e)      |  P=0.533N     P=0.512      P=0.513N     P=0.765N   |
|COCHRAN-ARMITAGE       |  P=0.786N                                          |  P=0.558N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.500      P=0.500N     P=0.747    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  3/50 (6%)    1/50 (2%)    2/50 (4%)    1/49 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   9.2%         3.2%         4.5%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  2/31 (6%)    1/31 (3%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   704          734 (T)      502          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.306N     P=0.301N     P=0.471N     P=0.263N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.347N     P=0.324N     P=0.475N     P=0.283N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.353N     P=0.295N     P=0.511N     P=0.266N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.351N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.309N     P=0.500N     P=0.316N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  4/50 (8%)    2/50 (4%)    2/50 (4%)    2/49 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         3.0%         0.0%      |  11.4%         6.5%         4.5%         5.7%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  2/31 (6%)    2/31 (6%)    0/34 (0%)    2/35 (6%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          643          ---       |   651          734 (T)      502          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.807        (e)        P=0.519        (e)      |  P=0.327N     P=0.342N     P=0.313N     P=0.290N   |
|INCIDENTAL TUMOR       |  P=0.721N       (e)        P=0.443        (e)      |  P=0.368N     P=0.369N     P=0.323N     P=0.315N   |
|LOGISTIC REGRESSION    |  P=0.796N       (e)        P=0.500        (e)      |  P=0.378N     P=0.322N     P=0.349N     P=0.303N   |
|COCHRAN-ARMITAGE       |  P=0.786N                                          |  P=0.385N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.339N     P=0.339N     P=0.349N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)  | 19/50 (38%)  19/50 (38%)  21/50 (42%)  21/49 (43%) |
|ADJUSTED (b)           |  13.3%        21.4%        13.8%         0.0%      |  55.8%        49.7%        55.0%        53.8%      |
|TERMINAL (d)           |  2/15 (13%)   3/14 (21%)   1/13 (8%)    0/2 (0%)   | 16/31 (52%)  12/31 (39%)  17/34 (50%)  17/35 (49%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      734 (T)      720          ---       |   687          609          651          699       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.547N     P=0.467      P=0.657      P=0.726N   |  P=0.512N     P=0.564N     P=0.561      P=0.541N   |
|INCIDENTAL TUMOR       |  P=0.414N     P=0.467      P=0.681      P=0.726N   |  P=0.530      P=0.566      P=0.516      P=0.557    |
|LOGISTIC REGRESSION    |  P=0.503N     P=0.467      P=0.681      P=0.726N   |  P=0.549N     P=0.554N     P=0.509      P=0.543N   |
|COCHRAN-ARMITAGE       |  P=0.116N                                          |  P=0.333                                           |
|FISHER EXACT           |               P=0.500      P=0.691N     P=0.247N   |               P=0.582N     P=0.419      P=0.387    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         7.2%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          549          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.495N     P=0.240        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.320N     P=0.235        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.361N     P=0.242        (e)          (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.369N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   3/50 (6%)    0/50 (0%)  | 20/50 (40%)  20/50 (40%)  21/50 (42%)  21/49 (43%) |
|ADJUSTED (b)           |  13.3%        27.1%        16.5%         0.0%      |  56.9%        52.3%        55.0%        53.8%      |
|TERMINAL (d)           |  2/15 (13%)   3/14 (21%)   1/13 (8%)    0/2 (0%)   | 16/31 (52%)  13/31 (42%)  17/34 (50%)  17/35 (49%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      549          643          ---       |   651          609          651          699       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.382N     P=0.193      P=0.470      P=0.726N   |  P=0.421N     P=0.567N     P=0.519N     P=0.458N   |
|INCIDENTAL TUMOR       |  P=0.194N     P=0.191      P=0.457      P=0.726N   |  P=0.475N     P=0.557      P=0.573N     P=0.532N   |
|LOGISTIC REGRESSION    |  P=0.180N     P=0.199      P=0.507      P=0.726N   |  P=0.454N     P=0.550N     P=0.575N     P=0.466N   |
|COCHRAN-ARMITAGE       |  P=0.073N                                          |  P=0.419                                           |
|FISHER EXACT           |               P=0.218      P=0.500      P=0.247N   |               P=0.581N     P=0.500      P=0.466    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    5/50 (10%)   3/50 (6%)    0/50 (0%)  | 22/50 (44%)  20/50 (40%)  23/50 (46%)  22/49 (45%) |
|ADJUSTED (b)           |  13.3%        27.1%        16.5%         0.0%      |  61.0%        52.3%        57.0%        56.3%      |
|TERMINAL (d)           |  2/15 (13%)   3/14 (21%)   1/13 (8%)    0/2 (0%)   | 17/31 (55%)  13/31 (42%)  17/34 (50%)  18/35 (51%) |
|FIRST INCIDENCE (DAYS) |   734 (T)      549          643          ---       |   651          609          502          699       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.382N     P=0.193      P=0.470      P=0.726N   |  P=0.396N     P=0.412N     P=0.509N     P=0.367N   |
|INCIDENTAL TUMOR       |  P=0.194N     P=0.191      P=0.457      P=0.726N   |  P=0.464N     P=0.451N     P=0.563N     P=0.441N   |
|LOGISTIC REGRESSION    |  P=0.180N     P=0.199      P=0.507      P=0.726N   |  P=0.449N     P=0.377N     P=0.561N     P=0.368N   |
|COCHRAN-ARMITAGE       |  P=0.073N                                          |  P=0.436                                           |
|FISHER EXACT           |               P=0.218      P=0.500      P=0.247N   |               P=0.420N     P=0.500      P=0.545    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |  12.6%         0.0%         7.7%         4.0%      |   0.0%         0.0%         2.9%         2.9%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    1/34 (3%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   570          ---          734 (T)      596       |   ---          ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.618      P=0.132N     P=0.335N     P=0.639N   |  P=0.330        (e)        P=0.518      P=0.524    |
|INCIDENTAL TUMOR       |  P=0.548N     P=0.130N     P=0.335N     P=0.358N   |  P=0.330        (e)        P=0.518      P=0.524    |
|LOGISTIC REGRESSION    |  P=0.505N     P=0.124N     P=0.303N     P=0.348N   |  P=0.330        (e)        P=0.518      P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.442N                                          |  P=0.298                                           |
|FISHER EXACT           |               P=0.121N     P=0.309N     P=0.309N   |                 (e)        P=0.500      P=0.495    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |
|ADJUSTED (b)           |  12.6%         0.0%         7.7%         4.0%      |   0.0%         0.0%         2.9%         2.9%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    1/34 (3%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   570          ---          734 (T)      596       |   ---          ---          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.618      P=0.132N     P=0.335N     P=0.639N   |  P=0.330        (e)        P=0.518      P=0.524    |
|INCIDENTAL TUMOR       |  P=0.548N     P=0.130N     P=0.335N     P=0.358N   |  P=0.330        (e)        P=0.518      P=0.524    |
|LOGISTIC REGRESSION    |  P=0.505N     P=0.124N     P=0.303N     P=0.348N   |  P=0.330        (e)        P=0.518      P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.442N                                          |  P=0.298                                           |
|FISHER EXACT           |               P=0.121N     P=0.309N     P=0.309N   |                 (e)        P=0.500      P=0.495    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |  10.6%         0.0%         7.7%         4.0%      |   0.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    1/13 (8%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   689          ---          734 (T)      596       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.405      P=0.252N     P=0.533N     P=0.628    |  P=0.232        (e)          (e)        P=0.524    |
|INCIDENTAL TUMOR       |  P=0.594      P=0.265N     P=0.504N     P=0.632N   |  P=0.232        (e)          (e)        P=0.524    |
|LOGISTIC REGRESSION    |  P=0.612      P=0.244N     P=0.496N     P=0.642N   |  P=0.232        (e)          (e)        P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.619N                                          |  P=0.210                                           |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.500N   |                 (e)          (e)        P=0.495    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/49 (51%)  19/50 (38%)  19/50 (38%)  18/45 (40%) | 30/49 (61%)  23/49 (47%)  25/50 (50%)  27/49 (55%) |
|ADJUSTED (b)           |  79.7%        66.7%        65.8%        82.7%      |  78.5%        61.2%        63.6%        65.4%      |
|TERMINAL (d)           |  9/14 (64%)   7/14 (50%)   6/13 (46%)   1/2 (50%)  | 23/31 (74%)  17/31 (55%)  20/34 (59%)  21/35 (60%) |
|FIRST INCIDENCE (DAYS) |   391          518          420          377       |   496          475          449          629       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.034 *    P=0.222N     P=0.237N     P=0.068    |  P=0.298N     P=0.122N     P=0.112N     P=0.155N   |
|INCIDENTAL TUMOR       |  P=0.362N     P=0.187N     P=0.110N     P=0.300N   |  P=0.374N     P=0.059N     P=0.071N     P=0.137N   |
|LOGISTIC REGRESSION    |  P=0.355N     P=0.147N     P=0.135N     P=0.234N   |  P=0.377N     P=0.061N     P=0.096N     P=0.151N   |
|COCHRAN-ARMITAGE       |  P=0.314N                                          |  P=0.546                                           |
|FISHER EXACT           |               P=0.135N     P=0.135N     P=0.194N   |               P=0.112N     P=0.178N     P=0.341N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/49 (51%)  19/50 (38%)  19/50 (38%)  18/45 (40%) | 30/49 (61%)  24/49 (49%)  26/50 (52%)  27/49 (55%) |
|ADJUSTED (b)           |  79.7%        66.7%        65.8%        82.7%      |  78.5%        62.3%        66.2%        65.4%      |
|TERMINAL (d)           |  9/14 (64%)   7/14 (50%)   6/13 (46%)   1/2 (50%)  | 23/31 (74%)  17/31 (55%)  21/34 (62%)  21/35 (60%) |
|FIRST INCIDENCE (DAYS) |   391          518          420          377       |   496          475          449          629       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.034 *    P=0.222N     P=0.237N     P=0.068    |  P=0.264N     P=0.167N     P=0.149N     P=0.155N   |
|INCIDENTAL TUMOR       |  P=0.362N     P=0.187N     P=0.110N     P=0.300N   |  P=0.330N     P=0.091N     P=0.101N     P=0.137N   |
|LOGISTIC REGRESSION    |  P=0.355N     P=0.147N     P=0.135N     P=0.234N   |  P=0.332N     P=0.089N     P=0.134N     P=0.151N   |
|COCHRAN-ARMITAGE       |  P=0.314N                                          |  P=0.511N                                          |
|FISHER EXACT           |               P=0.135N     P=0.135N     P=0.194N   |               P=0.155N     P=0.235N     P=0.341N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   3/50 (6%)    4/50 (8%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    3/50 (6%)    0/49 (0%)  |
|ADJUSTED (b)           |  20.1%        15.6%        26.2%        69.7%      |   0.0%         0.0%         8.8%         0.0%      |
|TERMINAL (d)           |  2/15 (13%)   1/14 (7%)    3/13 (23%)   1/2 (50%)  |  0/31 (0%)    0/31 (0%)    3/34 (9%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   528          637          688          672       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.183      P=0.393N     P=0.548N     P=0.358    |  P=0.617N       (e)        P=0.137        (e)      |
|INCIDENTAL TUMOR       |  P=0.576      P=0.378N     P=0.545N     P=0.569N   |  P=0.617N       (e)        P=0.137        (e)      |
|LOGISTIC REGRESSION    |  P=0.535      P=0.368N     P=0.497N     P=0.575N   |  P=0.617N       (e)        P=0.137        (e)      |
|COCHRAN-ARMITAGE       |  P=0.389N                                          |  P=0.656N                                          |
|FISHER EXACT           |               P=0.357N     P=0.500N     P=0.357N   |                 (e)        P=0.121        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   6.7%         5.3%        18.8%         0.0%      |   3.2%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    2/13 (15%)   0/2 (0%)   |  1/31 (3%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      713          688          ---       |   734 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.624      P=0.759      P=0.269      P=0.882N   |  P=0.456N     P=0.500N     P=0.482N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.579N     P=0.735      P=0.287      P=0.882N   |  P=0.456N     P=0.500N     P=0.482N     P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.690N     P=0.759      P=0.302      P=0.882N   |  P=0.456N     P=0.500N     P=0.482N     P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.339N                                          |  P=0.478N                                          |
|FISHER EXACT           |               P=0.753N     P=0.309      P=0.500N   |               P=0.500N     P=0.500N     P=0.505N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    4/50 (8%)    4/50 (8%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   6.7%        15.6%        20.4%         0.0%      |   3.2%         6.5%         0.0%         0.0%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    2/13 (15%)   0/2 (0%)   |  1/31 (3%)    2/31 (6%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      560          266          ---       |   734 (T)      734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.487N     P=0.182      P=0.157      P=0.882N   |  P=0.189N     P=0.500      P=0.482N     P=0.476N   |
|INCIDENTAL TUMOR       |  P=0.282N     P=0.155      P=0.169      P=0.882N   |  P=0.189N     P=0.500      P=0.482N     P=0.476N   |
|LOGISTIC REGRESSION    |  P=0.323N     P=0.171      P=0.181      P=0.882N   |  P=0.189N     P=0.500      P=0.482N     P=0.476N   |
|COCHRAN-ARMITAGE       |  P=0.155N                                          |  P=0.213N                                          |
|FISHER EXACT           |               P=0.181      P=0.181      P=0.500N   |               P=0.500      P=0.500N     P=0.505N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%        10.9%         0.0%         0.0%      |   0.0%         6.5%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    2/31 (6%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          560          ---          ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380N     P=0.122        (e)          (e)      |  P=0.345N     P=0.238        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.211N     P=0.110        (e)          (e)      |  P=0.345N     P=0.238        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.259N     P=0.120        (e)          (e)      |  P=0.345N     P=0.238        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.255N                                          |  P=0.373N                                          |
|FISHER EXACT           |               P=0.121        (e)          (e)      |               P=0.247        (e)          (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |  11.2%         9.1%        15.4%        54.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/15 (7%)    0/14 (0%)    2/13 (15%)   1/2 (50%)  |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   528          637          734 (T)      672       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306      P=0.516N     P=0.543N     P=0.462    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.613      P=0.525N     P=0.529N     P=0.682N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.608      P=0.501N     P=0.500N     P=0.606N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.491N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%         8.8%         0.0%         0.0%      |   0.0%         3.2%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    1/31 (3%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          668          ---          ---       |   ---          734 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.574N     P=0.235        (e)          (e)      |  P=0.556N     P=0.500        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.331N     P=0.202        (e)          (e)      |  P=0.556N     P=0.500        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.447N     P=0.230        (e)          (e)      |  P=0.556N     P=0.500        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.369N                                          |  P=0.580N                                          |
|FISHER EXACT           |               P=0.247        (e)          (e)      |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |   9.6%         7.1%         7.7%         0.0%      |   0.0%         0.0%         5.9%         0.0%      |
|TERMINAL (d)           |  1/15 (7%)    1/14 (7%)    1/13 (8%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    2/34 (6%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   640          734 (T)      734 (T)      ---       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.453N     P=0.536N     P=0.530N     P=0.498N   |  P=0.670N       (e)        P=0.259        (e)      |
|INCIDENTAL TUMOR       |  P=0.378N     P=0.502N     P=0.567N     P=0.362N   |  P=0.670N       (e)        P=0.259        (e)      |
|LOGISTIC REGRESSION    |  P=0.338N     P=0.512N     P=0.495N     P=0.357N   |  P=0.670N       (e)        P=0.259        (e)      |
|COCHRAN-ARMITAGE       |  P=0.194N                                          |  P=0.702N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.247N   |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   3/50 (6%)    3/50 (6%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    3/50 (6%)    0/49 (0%)  |
|ADJUSTED (b)           |  20.1%        15.6%        23.1%        54.5%      |   0.0%         0.0%         8.8%         0.0%      |
|TERMINAL (d)           |  2/15 (13%)   1/14 (7%)    3/13 (23%)   1/2 (50%)  |  0/31 (0%)    0/31 (0%)    3/34 (9%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   528          637          734 (T)      672       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.483      P=0.393N     P=0.407N     P=0.646    |  P=0.617N       (e)        P=0.137        (e)      |
|INCIDENTAL TUMOR       |  P=0.453N     P=0.378N     P=0.417N     P=0.407N   |  P=0.617N       (e)        P=0.137        (e)      |
|LOGISTIC REGRESSION    |  P=0.422N     P=0.368N     P=0.353N     P=0.342N   |  P=0.617N       (e)        P=0.137        (e)      |
|COCHRAN-ARMITAGE       |  P=0.225N                                          |  P=0.656N                                          |
|FISHER EXACT           |               P=0.357N     P=0.357N     P=0.218N   |                 (e)        P=0.121        (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   3/50 (6%)    3/50 (6%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)  |
|ADJUSTED (b)           |  20.1%        15.6%        23.1%        54.5%      |   0.0%         0.0%         5.9%         0.0%      |
|TERMINAL (d)           |  2/15 (13%)   1/14 (7%)    3/13 (23%)   1/2 (50%)  |  0/31 (0%)    0/31 (0%)    2/34 (6%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   528          637          734 (T)      672       |   ---          ---          734 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.483      P=0.393N     P=0.407N     P=0.646    |  P=0.670N       (e)        P=0.259        (e)      |
|INCIDENTAL TUMOR       |  P=0.453N     P=0.378N     P=0.417N     P=0.407N   |  P=0.670N       (e)        P=0.259        (e)      |
|LOGISTIC REGRESSION    |  P=0.422N     P=0.368N     P=0.353N     P=0.342N   |  P=0.670N       (e)        P=0.259        (e)      |
|COCHRAN-ARMITAGE       |  P=0.225N                                          |  P=0.702N                                          |
|FISHER EXACT           |               P=0.357N     P=0.357N     P=0.218N   |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 36/50 (72%)  33/50 (66%)  40/50 (80%)  44/50 (88%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |                                                    |
|TERMINAL (d)           | 15/15 (100%) 14/14 (100%) 13/13 (100%)  2/2 (100%) |                                                    |
|FIRST INCIDENCE (DAYS) |   497          538          420          483       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.480N     P=0.259      P<0.001 ** |                                                    |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.463N     P=0.146      P=0.002 ** |                                                    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.404N     P=0.194      P=0.001 ** |                                                    |
|COCHRAN-ARMITAGE       |  P=0.010 **                                        |                                                    |
|FISHER EXACT           |               P=0.333N     P=0.241      P=0.039 *  |                                                    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/49 (12%)   3/50 (6%)    2/50 (4%)  |  2/48 (4%)    4/50 (8%)    2/50 (4%)    3/49 (6%)  |
|ADJUSTED (b)           |  20.0%        32.7%        13.0%        30.8%      |   6.2%        12.4%         5.9%         8.6%      |
|TERMINAL (d)           |  3/15 (20%)   3/14 (21%)   1/13 (8%)    0/2 (0%)   |  1/31 (3%)    3/31 (10%)   2/34 (6%)    3/35 (9%)  |
|FIRST INCIDENCE (DAYS) |   734 (T)      617          591          665       |   721          731          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.366      P=0.223      P=0.633      P=0.208    |  P=0.580N     P=0.348      P=0.666N     P=0.554    |
|INCIDENTAL TUMOR       |  P=0.478N     P=0.205      P=0.617      P=0.463    |  P=0.591N     P=0.307      P=0.677N     P=0.535    |
|LOGISTIC REGRESSION    |  P=0.539N     P=0.217      P=0.659N     P=0.390    |  P=0.585N     P=0.354      P=0.675N     P=0.558    |
|COCHRAN-ARMITAGE       |  P=0.217N                                          |  P=0.567                                           |
|FISHER EXACT           |               P=0.233      P=0.661N     P=0.500N   |               P=0.359      P=0.676N     P=0.510    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |  0/48 (0%)    0/50 (0%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   9.4%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   661          ---          ---          ---       |   ---          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.370N     P=0.242N     P=0.238N     P=0.495N   |  P=0.232        (e)          (e)        P=0.524    |
|INCIDENTAL TUMOR       |  P=0.211N     P=0.270N     P=0.183N     P=0.207N   |  P=0.232        (e)          (e)        P=0.524    |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.245N     P=0.236N     P=0.359N   |  P=0.232        (e)          (e)        P=0.524    |
|COCHRAN-ARMITAGE       |  P=0.241N                                          |  P=0.213                                           |
|FISHER EXACT           |               P=0.253N     P=0.247N     P=0.247N   |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   6/49 (12%)   3/50 (6%)    2/50 (4%)  |  2/48 (4%)    4/50 (8%)    2/50 (4%)    4/49 (8%)  |
|ADJUSTED (b)           |  27.5%        32.7%        13.0%        30.8%      |   6.2%        12.4%         5.9%        11.4%      |
|TERMINAL (d)           |  3/15 (20%)   3/14 (21%)   1/13 (8%)    0/2 (0%)   |  1/31 (3%)    3/31 (10%)   2/34 (6%)    4/35 (11%) |
|FIRST INCIDENCE (DAYS) |   661          617          591          665       |   721          731          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.553      P=0.481      P=0.384N     P=0.444    |  P=0.436      P=0.348      P=0.666N     P=0.394    |
|INCIDENTAL TUMOR       |  P=0.255N     P=0.441      P=0.363N     P=0.505N   |  P=0.426      P=0.307      P=0.677N     P=0.377    |
|LOGISTIC REGRESSION    |  P=0.342N     P=0.474      P=0.349N     P=0.676N   |  P=0.431      P=0.354      P=0.675N     P=0.396    |
|COCHRAN-ARMITAGE       |  P=0.112N                                          |  P=0.371                                           |
|FISHER EXACT           |               P=0.486      P=0.357N     P=0.218N   |               P=0.359      P=0.676N     P=0.349    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    3/50 (6%)    5/50 (10%)   3/49 (6%)  |
|ADJUSTED (b)           |                                                    |   6.2%         7.5%        14.7%         8.6%      |
|TERMINAL (d)           |                                                    |  1/31 (3%)    0/31 (0%)    5/34 (15%)   3/35 (9%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   721          601          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.569      P=0.511      P=0.252      P=0.554    |
|INCIDENTAL TUMOR       |                                                    |  P=0.543      P=0.571      P=0.244      P=0.535    |
|LOGISTIC REGRESSION    |                                                    |  P=0.546      P=0.508      P=0.238      P=0.558    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.495                                           |
|FISHER EXACT           |                                                    |               P=0.500      P=0.218      P=0.490    |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  21
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    4/50 (8%)    5/50 (10%)   3/49 (6%)  |
|ADJUSTED (b)           |                                                    |   6.2%         9.3%        14.7%         8.6%      |
|TERMINAL (d)           |                                                    |  1/31 (3%)    0/31 (0%)    5/34 (15%)   3/35 (9%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   721          462          734 (T)      734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.545N     P=0.355      P=0.252      P=0.554    |
|INCIDENTAL TUMOR       |                                                    |  P=0.590      P=0.433      P=0.244      P=0.535    |
|LOGISTIC REGRESSION    |                                                    |  P=0.585      P=0.309      P=0.238      P=0.558    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.568                                           |
|FISHER EXACT           |                                                    |               P=0.339      P=0.218      P=0.490    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   0.0%         2.7%         0.0%         0.0%      |   5.7%         0.0%         0.0%         2.9%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    1/35 (3%)  |
|FIRST INCIDENCE (DAYS) |   ---          601          ---          ---       |   683          ---          ---          734 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.664N     P=0.490        (e)          (e)      |  P=0.617N     P=0.233N     P=0.231N     P=0.458N   |
|INCIDENTAL TUMOR       |  P=0.515N     P=0.523        (e)          (e)      |  P=0.641N     P=0.280N     P=0.256N     P=0.508N   |
|LOGISTIC REGRESSION    |  P=0.558N     P=0.515        (e)          (e)      |  P=0.635N     P=0.230N     P=0.228N     P=0.477N   |
|COCHRAN-ARMITAGE       |  P=0.576N                                          |  P=0.656N                                          |
|FISHER EXACT           |               P=0.500        (e)          (e)      |               P=0.247N     P=0.247N     P=0.508N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  22
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  26/50 (52%)  32/50 (64%)   9/50 (18%) | 13/50 (26%)  18/50 (36%)  16/50 (32%)  11/49 (22%) |
|ADJUSTED (b)           |  74.7%        79.3%        83.1%        62.2%      |  34.0%        46.2%        38.3%        25.0%      |
|TERMINAL (d)           |  7/15 (47%)   8/14 (57%)   7/13 (54%)   1/2 (50%)  |  7/31 (23%)  11/31 (35%)   9/34 (26%)   5/35 (14%) |
|FIRST INCIDENCE (DAYS) |   570          582          496          383       |   507          412          486          448       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.412N     P=0.543      P=0.264      P=0.287N   |  P=0.118N     P=0.217      P=0.429      P=0.315N   |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.562N     P=0.175      P<0.001N** |  P=0.171N     P=0.198      P=0.402      P=0.398N   |
|LOGISTIC REGRESSION    |  P<0.001N**   P=0.555N     P=0.166      P<0.001N** |  P=0.195N     P=0.222      P=0.370      P=0.458N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.196N                                          |
|FISHER EXACT           |               P=0.500N     P=0.208      P<0.001N** |               P=0.194      P=0.330      P=0.430N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%        10.7%         2.2%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/15 (0%)    0/14 (0%)    0/13 (0%)    0/2 (0%)   |  0/31 (0%)    0/31 (0%)    0/34 (0%)    0/35 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          692          527          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.579N     P=0.250      P=0.496        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.271N     P=0.202      P=0.581        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.390N     P=0.229      P=0.525        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.378N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247      P=0.500        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  23
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 48/50 (96%)  44/50 (88%)  48/50 (96%)  48/50 (96%) | 37/50 (74%)  39/50 (78%)  37/50 (74%)  39/49 (80%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  90.1%        88.5%        88.0%        86.7%      |
|TERMINAL (d)           | 15/15 (100%) 14/14 (100%) 13/13 (100%)  2/2 (100%) | 27/31 (87%)  26/31 (84%)  29/34 (85%)  29/35 (83%) |
|FIRST INCIDENCE (DAYS) |   391          518          266          377       |   496          475          449          629       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.452N     P=0.475      P<0.001 ** |  P=0.293N     P=0.441      P=0.341N     P=0.386N   |
|INCIDENTAL TUMOR       |  P=0.291      P=0.310N     P=0.679N     P=0.725N   |  P=0.442N     P=0.544N     P=0.316N     P=0.495N   |
|LOGISTIC REGRESSION    |  P=0.184      P=0.205N     P=0.667      P=0.586    |  P=0.444N     P=0.565      P=0.381N     P=0.500N   |
|COCHRAN-ARMITAGE       |  P=0.296                                           |  P=0.346                                           |
|FISHER EXACT           |               P=0.134N     P=0.691N     P=0.691N   |               P=0.408      P=0.590N     P=0.337    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  32/50 (64%)  37/50 (74%)  17/50 (34%) | 20/50 (40%)  25/50 (50%)  22/50 (44%)  14/49 (29%) |
|ADJUSTED (b)           |  83.6%        85.7%        89.6%        85.3%      |  47.8%        56.7%        49.2%        31.9%      |
|TERMINAL (d)           |  9/15 (60%)   9/14 (64%)   9/13 (69%)   1/2 (50%)  | 10/31 (32%)  13/31 (42%)  12/34 (35%)   7/35 (20%) |
|FIRST INCIDENCE (DAYS) |   497          560          420          383       |   318          412          393          448       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.225      P=0.532      P=0.310      P=0.368    |  P=0.029N*    P=0.264      P=0.538      P=0.107N   |
|INCIDENTAL TUMOR       |  P<0.001N**   P=0.576      P=0.265      P=0.001N** |  P=0.054N     P=0.316      P=0.453      P=0.184N   |
|LOGISTIC REGRESSION    |  P=0.001N**   P=0.551N     P=0.247      P=0.003N** |  P=0.055N     P=0.335      P=0.527      P=0.165N   |
|COCHRAN-ARMITAGE       |  P<0.001N**                                        |  P=0.044N*                                         |
|FISHER EXACT           |               P=0.500N     P=0.257      P=0.001N** |               P=0.211      P=0.420      P=0.162N   |
|=================================================================================================================================|
         DATE: 03/14/96                     EXPERIMENT: 05210 TEST: 03                                                 PAGE  24
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ETHYLBENZENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      75 PPM       250          750       |   CONTROL      75 PPM       250          750       |
|                       |                             PPM          PPM       |                             PPM          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  45/50 (90%)  50/50 (100%) 50/50 (100%)| 42/50 (84%)  45/50 (90%)  44/50 (88%)  46/49 (94%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  93.3%        90.0%        89.8%        93.9%      |
|TERMINAL (d)           | 15/15 (100%) 14/14 (100%) 13/13 (100%)  2/2 (100%) | 28/31 (90%)  26/31 (84%)  29/34 (85%)  32/35 (91%) |
|FIRST INCIDENCE (DAYS) |   391          518          266          377       |   318          412          393          448       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.454N     P=0.430      P<0.001 ** |  P=0.389N     P=0.395      P=0.470N     P=0.494N   |
|INCIDENTAL TUMOR       |  P=0.160      P=0.220N     P=0.500        (e)      |  P=0.231      P=0.611      P=0.552N     P=0.342    |
|LOGISTIC REGRESSION    |  P=0.059      P=0.151N     P=0.349        (e)      |  P=0.236      P=0.442      P=0.595      P=0.318    |
|COCHRAN-ARMITAGE       |  P=0.081                                           |  P=0.124                                           |
|FISHER EXACT           |               P=0.102N     P=0.500      P=0.500    |               P=0.277      P=0.387      P=0.106    |
|=================================================================================================================================|
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).