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TDMS Study 05211-05 Pathology Tables


NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01
Route: DOSED FEED                                                                                                 Time: 12:57:48

                                                       FINAL#3;REVISION#1




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X              X                    X        X           X     X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                             X            |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X                       X     X           X                       X   |             
      Pars Intermedia, Adenoma             |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                    X                    X  X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X           X              X              X        X           X     X   |             
      Carcinoma                            |                         X                                                |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |          X        X                                                  X  X|             
      Sarcoma Stromal                      |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                                   +                              |             
      Iliac, Leukemia Mononuclear          |       X                                                                  |             
      Mediastinal, Leukemia Mononuclear    |                                           X                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X              X                    X        X           X     X   |             
      Osteosarcoma, Metastatic, Bone       |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Thymoma Benign                       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         | X  X  X        X  X     X     X  X           X  X  X              X      |             
      Fibroadenoma, Multiple               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Schwannoma Malignant                 |                      X                                                   |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                 X                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|             
                                           | 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0                                      | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |             
      Leukemia Mononuclear                 |                                           X                              |             
      Osteosarcoma, Metastatic, Bone       |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                +                                      +                  |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                               +                                          |             
      Carcinoma                            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                   X                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X              X                    X        X           X     X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3|            |
                                           | 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    0                                      | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    PPM                                    | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X                    X     X                          X        X  X      |         13 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3|            |
                                           | 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    0                                      | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    PPM                                    | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                X         |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Pars Distalis, Adenoma               |    X  X     X  X        X           X        X     X                 X   |         15 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |                                                                          |          4 |
      C-Cell, Carcinoma                    |                                     X              X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                        X                             X  X|         10 |
      Carcinoma                            |                   X                                                      |          2 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3|            |
                                           | 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    0                                      | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    PPM                                    | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Polyp Stromal                        | X     X        X     X        X                                   X      |         10 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |    +                 +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X     X                                   X  X      |          6 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                +  +  +   |   5        |
      Iliac, Leukemia Mononuclear          |                                                                   X      |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                X         |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                X  X      |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X                          X                                   X  X      |          5 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                    X     X                    X     X        X  X      |         14 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3|            |
                                           | 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    0                                      | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    PPM                                    | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma                         | X     X              X                             X     X  X            |         18 |
      Fibroadenoma, Multiple               |    X        X                          X     X                 X         |          5 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                               X                                          |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                   +      |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                   +      |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                         X  X      |          4 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3|            |
                                           | 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |
    0                                      | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |
    PPM                                    | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |    +        +                                               +            |   5        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                            X                                             |          3 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                    X     X                    X     X        X  X      |         14 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    280                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 |          X  X     X  X        X  X                       X               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                       +                 +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    280                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |          X           X                                                   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Pars Distalis, Adenoma               | X     X  X  X  X              X     X  X     X     X              X  X   |             
      Pars Intermedia, Carcinoma           |                                           X                              |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                                                                      X   |             
      C-Cell, Carcinoma                    |                         X                                                |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                    X                 X|             
      Carcinoma                            |                                                                          |             
      Bilateral, Adenoma                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    280                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X  X                                                            |             
      Bilateral, Granulosa Cell Tumor      |                                                                          |             
          Benign                           |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |    X                                   X                    X           X|             
      Polyp Stromal, Multiple              | X                                                                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |          +  M        +                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X     X  X                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +        +                                                   |             
      Mediastinal, Leukemia Mononuclear    |             X        X                                                   |             
      Pancreatic, Leukemia Mononuclear     |             X        X                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X        X                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X                                                   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X     X  X        X  X                       X  X            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X                                                   |             
      Thymoma Malignant                    |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                   X     X                    X              X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    280                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibroadenoma, Multiple               |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor Malignant        |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X     X  X                                                   |             
      Osteosarcoma, Metastatic, Bone       |                            X                                             |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |    +                                                                 +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    280                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                                                            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X     X  X        X  X                       X  X            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    280                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |    X                                                                     |          1 |
      Leukemia Mononuclear                 |          X     X                 X           X  X  X  X  X               |         15 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +              +              +           +                     |   6        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    280                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                                            X                  |          4 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                            X                  |          3 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X                                                                     |          1 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
      Pars Distalis, Adenoma               |       X  X  X  X        X                 X                 X        X  X|         21 |
      Pars Intermedia, Carcinoma           |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, C-Cell, Adenoma           |                                                 X                        |          1 |
      C-Cell, Adenoma                      |          X              X                 X                             X|          5 |
      C-Cell, Carcinoma                    |                                                    X                     |          2 |
      Follicular Cell, Adenoma             |                                           X                              |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    280                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X     X  X           X     X                          X           X|         10 |
      Carcinoma                            |          X                          X           X                        |          3 |
      Bilateral, Adenoma                   |                                        X           X                     |          2 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Granulosa Cell Tumor      |                                                                          |            |
          Benign                           |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        | X                       X                 X                              |          7 |
      Polyp Stromal, Multiple              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                   X  X                        |          7 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   3        |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                       X                  |          4 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X  X                  |          4 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    280                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X     X                 X           X  X  X  X  X           X   |         17 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroadenoma                         |       X  X        X              X     X  X     X              X        X|         13 |
      Fibroadenoma, Multiple               |                X     X              X                                X   |          5 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granular Cell Tumor Malignant        |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                            +                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    280                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                   X        X  X               |          8 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                                            X                  |          4 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X     X                 X           X  X  X  X  X           X   |         17 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|             
                                           | 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    830                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X  X              X                 X        X                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|             
                                           | 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    830                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |    X                          X                          X     X         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X     X     X     X  X              X     X        X        X  X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X                                X                              |             
      Follicular Cell, Carcinoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                         X           X              X|             
      Carcinoma                            |    X  X                                                                  |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                          |             
      Polyp Stromal                        |       X           X                    X                                X|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|             
                                           | 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    830                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |    +                                            +                        |             
      Granular Cell Tumor Benign           |                                                 X                        |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                         X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                             +                  |             
      Mediastinal, Leukemia Mononuclear    |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 | X        X  X              X                 X        X                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Thymoma Benign                       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         | X  X  X  X           X     X              X  X  X           X     X  X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                    X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|             
                                           | 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    830                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                      +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                               +                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|             
                                           | 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    830                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X  X              X                 X        X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    830                                    | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X     X              X                 X  X  X     X     X        X|         16 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangiosarcoma, Metastatic, Spleen  |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    830                                    | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                            X|          4 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Pheochromocytoma Benign              |                                                                          |          4 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                X                                                         |          1 |
      Carcinoma                            |                                           X                              |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
      Pars Distalis, Adenoma               |       X  X        X  X  X     X     X        X  X     X     X  X  X  X   |         25 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      | X                                                     X                  |          4 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    830                                    | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |    X                          X        X                          X      |          8 |
      Carcinoma                            |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leiomyoma                            |                X                                                         |          1 |
      Polyp Stromal                        |                X                                   X                    X|          7 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                         +                                                |   3        |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Squamous Cell Papilloma              |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                            X|          4 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                     +|   4        |
      Mediastinal, Leukemia Mononuclear    |                                                                         X|          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                            X                                            X|          3 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X     X     X              X                 X  X  X     X     X        X|         16 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    830                                    | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroadenoma                         | X  X  X                             X                 X  X        X  X   |         20 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                X                                                         |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glioma Malignant                     |                                                 X                        |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                           +           +                  |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                           +           +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7|            |
                                           | 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    830                                    | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                       X                     |          3 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |       +                                               +                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                    X                    X|          3 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X     X              X                 X  X  X     X     X        X|         16 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2500                                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +              +                 +                       +   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2500                                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Complex             |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Pars Distalis, Adenoma               | X     X     X           X     X        X  X     X  X  X  X     X        X|             
      Pars Intermedia, Adenoma             |    X                                                                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                               X                          X               |             
      C-Cell, Carcinoma                    |                   X                                                      |             
      Follicular Cell, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                           +                              |             
      Mesothelioma Malignant               |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X     X                             X              X                 X|             
      Bilateral, Adenoma                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Polyp Stromal                        |                                  X     X           X     X     X     X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2500                                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +     +                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                                   +                     |             
      Leukemia Mononuclear                 |                X                                                         |             
      Deep Cervical, Leukemia Mononuclear  |                X                                                         |             
      Iliac, Leukemia Mononuclear          |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                               X                                X         |             
      Fibroadenoma                         |    X  X  X  X        X  X     X  X                                       |             
      Fibroadenoma, Multiple               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2500                                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Basal Cell Adenoma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Adrenal Cortex|                                                    X                     |             
      Leukemia Mononuclear                 |                X                                                         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +     +|             
      Carcinoma                            |                                                                   X     X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|             
                                           | 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    2500                                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    PPM                                    | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X                                       |             
      Mesothelioma Malignant               |                                           X                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0|            |
                                           | 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    2500                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma, Multiple     |                                        X                                 |          1 |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                +                                         +               |   6        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0|            |
                                           | 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    2500                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Complex             |    X                                                                     |          1 |
      Pheochromocytoma Benign              |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X        X  X           X  X           X  X     X     X  X     X        X|         25 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |                                                                X         |          3 |
      C-Cell, Carcinoma                    |                                                 X     X                  |          3 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   1        |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |    X        X        X                 X                                 |          9 |
      Bilateral, Adenoma                   |                            X                                             |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0|            |
                                           | 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    2500                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |          X     X                          X                    X         |         10 |
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                 +  +     +               |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                    +                     |   3        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                    X                     |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                    X                     |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |          1 |
      Renal, Leukemia Mononuclear          |                                                    X                     |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          3 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0|            |
                                           | 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    2500                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                                                                          |          2 |
      Fibroadenoma                         |                         X  X     X     X  X           X              X  X|         16 |
      Fibroadenoma, Multiple               |                                                 X                        |          1 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Adenoma                   |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Adrenal Cortex|                                                                          |          1 |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
      Osteosarcoma, Metastatic, Bone       |                                              X                           |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                               +                                          |   1        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0|            |
                                           | 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    2500                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Eye                                     |                                                    +                     |   2        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |       M                             +                                    |   3        |
      Carcinoma                            |                                     X                                    |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          2 |
      Osteosarcoma, Metastatic, Bone       |                                              X                           |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                     |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|             
                                           | 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                X         |             
      Leukemia Mononuclear                 |    X     X  X        X     X        X  X        X  X  X  X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                                        +               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Mixed Tumor Benign                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X           X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|             
                                           | 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
   Blood Vessel                            |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X           X           X                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                 X           X           X                 X   |             
      Pheochromocytoma Malignant           | X                                                                        |             
      Pheochromocytoma Benign              |             X                                                            |             
      Bilateral, Pheochromocytoma Benign   |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                 X   |             
      Pars Distalis, Adenoma               | X              X                                X  X        X           X|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                         X                 X           X                  |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|             
                                           | 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X           X                    X|             
      Carcinoma                            |    X                             X  X                                    |             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X        X  X     X  X     X  X     X  X  X  X  X     X  X|             
      Interstitial Cell, Adenoma           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X                       X  X  X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +  +                 +              +              +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                      X   |             
      Mediastinal, Leukemia Mononuclear    |             X                          X              X              X   |             
      Pancreatic, Leukemia Mononuclear     |                      X                 X                                 |             
      Renal, Leukemia Mononuclear          |                                        X                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                       X  X        X  X  X     X        X   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                 X           X                 X   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|             
                                           | 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X        X  X  X        X  X        X  X  X  X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Thymoma Malignant                    |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                             X            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                 X                        |             
      Trichoepithelioma                    |                                                                          |             
      Sebaceous Gland, Adenoma             |                                                       X                  |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Hemangiopericytoma               |                                                                   X      |             
      Subcutaneous Tissue, Hemangiosarcoma |                   X                                                      |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                X                                                         |             
      Leukemia Mononuclear                 |                      X     X                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|             
                                           | 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    PPM                                    | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X                       X                 X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Eye                                     |       +                 +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X           X        X  X     X  X        X   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X        X  X  X        X  X        X  X  X  X  X  X     X   |             
      Mesothelioma Malignant               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Carcinoma                            |                               X                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X     X     X     X  X  X     X  X     X        X        X  X      |         27 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +  +     +           +     +  +                                    |   8        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                    X        X                                    |          4 |
      Mixed Tumor Benign                   |       X        X                                                         |          2 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X                                    |          3 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X        X                           |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                             X        X                           |          7 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                             X        X                           |          8 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                   X           X  X     X              X                  |          6 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                X  X                                                      |          2 |
      Carcinoma                            | X                             X        X                                 |          3 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pars Distalis, Adenoma               |                                           X  X  X  X  X  X        X  X  X|         15 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |                            X                                             |          1 |
      Follicular Cell, Adenoma             |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                     +        +                           |   2        |
      Mesothelioma Malignant               |                                     X        X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                                X                                 |          5 |
      Carcinoma                            |                                                                          |          3 |
      Leukemia Mononuclear                 |                            X        X                                    |          2 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                      X   |          1 |
      Leukemia Mononuclear                 |                                     X                                    |          2 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X                                    |          2 |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma|       X  X  X  X  X           X  X  X  X  X     X     X  X  X  X  X      |         34 |
      Interstitial Cell, Adenoma           | X                       X  X                       X                 X  X|          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X                 X  X  X     X        X        X        X         |         18 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +                    +        +        +        +                  |  12        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                     X                                    |          1 |
      Iliac, Leukemia Mononuclear          |                                     X                                    |          2 |
      Mediastinal, Leukemia Mononuclear    |    X  X                    X        X        X                           |          9 |
      Pancreatic, Leukemia Mononuclear     |       X                    X        X                 X                  |          6 |
      Renal, Leukemia Mononuclear          |                            X        X                                    |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X  X                 X  X        X        X        X                  |         15 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X  X     X                                    |          7 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X     X     X     X  X  X     X  X     X        X        X  X      |         28 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |    X                    X  X        X        X                           |          6 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroadenoma                         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                                                 X  X                     |          3 |
      Trichoepithelioma                    |                                                                X         |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue,                 |                                                                          |            |
          Hemangiopericytoma               |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          | X                                                                        |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                                                          X               |          2 |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                            M                     |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +                                            +                     |   2        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X                    X        X        X        X                  |         11 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1|            |
                                           | 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    0                                      | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    PPM                                    | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                     +                                    |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X           X        X        X        X                           |         15 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X                                    |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X     X     X     X  X  X     X  X     X        X        X  X      |         28 |
      Mesothelioma Malignant               |                                     X        X                           |          2 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    280                                    | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                 X                        |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Adenoma               |                                                                   X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X  X  X     X  X     X              X  X|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +                             +                                +      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X  X        X              X              X   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X     X                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X  X                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    280                                    | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X  X              X                    X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X     X  X  X           X     X              X   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X  X                 X                 X|             
      Pheochromocytoma Benign              |          X                       X           X        X                  |             
      Bilateral, Pheochromocytoma Benign   |                         X                 X                              |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X     X                                                      |             
      Carcinoma                            |                                           X                              |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X  X              X                       X|             
      Pars Distalis, Adenoma               |                                        X           X     X               |             
      Pars Intermedia, Adenoma             |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X           X                                                            |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |             X                                                            |             
      Follicular Cell, Carcinoma           |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    280                                    | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Carcinoma                            |                                     X     X                              |             
      Leukemia Mononuclear                 |                                  X                                      X|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X     X  X  X     X     X  X  X     X     X  X  X     X  X  X  X   |             
      Interstitial Cell, Adenoma           | X        X           X                 X     X           X              X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X        X     X     X  X  X  X  X  X  X     X  X     X              X  X|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +        +     +           +  +     +           +     +              +   |             
      Leukemia Mononuclear                 |                            X  X                                          |             
      Deep Cervical, Leukemia Mononuclear  | X                             X                                          |             
      Iliac, Leukemia Mononuclear          |                               X                       X                  |             
      Inguinal, Leukemia Mononuclear       |                            X                                             |             
      Mediastinal, Leukemia Mononuclear    | X        X     X           X  X     X           X                        |             
      Pancreatic, Leukemia Mononuclear     | X        X                 X  X     X           X                    X   |             
      Renal, Leukemia Mononuclear          |                            X  X                       X                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X        X  X  X  X  X  X        X     X              X  X|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    280                                    | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X           X  X  X  X  X  X  X              X              X  X|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X  X  X     X  X     X              X  X|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X  X  X                 X              X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |          X        X                                                  X   |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |          X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |             
      Subcutaneous Tissue, Lipoma          |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                               X                 X                    X   |             
      Oligodendroglioma Malignant          |    X                                                                     |             
      Pineal Gland, Meningioma Malignant   |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|             
                                           | 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    280                                    | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    PPM                                    | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Peripheral Nerve                        |    +                             +     +                             +   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +                             +     +                             +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X  X     X     X  X     X  X  X  X     X  X     X              X  X|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X  X  X  X        X     X              X  X|             
      Renal Tubule, Stromal Nephroma       |                                                                         X|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                    X                 X|             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X  X  X  X  X  X     X  X     X              X  X|             
      Mesothelioma Malignant               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                     X               |          3 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                   X     X                                                |          3 |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                    X                     |          1 |
      Leukemia Mononuclear                 | X  X  X           X  X  X  X     X        X              X  X  X         |         30 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                     +     +           +                  |   7        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          7 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X                                                                     |          4 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                     X     X         |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X  X  X                             X  X            |         13 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                            X              X              X               |          8 |
      Pheochromocytoma Benign              |    X              X  X  X                             X     X  X         |         11 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X                                   X     X                           |          5 |
      Carcinoma                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                   X  X            |          7 |
      Pars Distalis, Adenoma               |       X        X        X     X                       X        X         |          9 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Adenoma                      |                                  X                                X     X|          5 |
      C-Cell, Carcinoma                    |                               X                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                     X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                                      +   |   1        |
      Mesothelioma Malignant               |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |    X                                                     X  X            |          5 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X           X     X  X  X        X  X  X     X        X           X  X  X|         30 |
      Interstitial Cell, Adenoma           |    X     X                    X           X              X  X            |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                    X                     |          1 |
      Leukemia Mononuclear                 |    X  X           X  X  X  X              X              X  X  X         |         25 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +           +  +  +  +              +        +     +  +  +     +   |  21        |
      Leukemia Mononuclear                 |                            X                             X               |          4 |
      Deep Cervical, Leukemia Mononuclear  |                                                          X               |          3 |
      Iliac, Leukemia Mononuclear          |    X                                                     X  X            |          5 |
      Inguinal, Leukemia Mononuclear       |                                                          X               |          2 |
      Mediastinal, Leukemia Mononuclear    |    X  X              X     X                                X  X         |         13 |
      Pancreatic, Leukemia Mononuclear     |    X  X           X  X  X                 X              X  X            |         15 |
      Renal, Leukemia Mononuclear          |    X                 X                                                   |          5 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X  X  X              X              X  X  X         |         21 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X  X                    X                 X  X         |         18 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X           X  X  X  X     X        X              X  X  X  X      |         31 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |    X              X  X                                   X  X            |         11 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibroadenoma                         |                                  X                                       |          2 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Adenoma                   |                                                                   X      |          1 |
      Basal Cell Carcinoma                 |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Keratoacanthoma                      |                                                                          |          3 |
      Squamous Cell Papilloma              |                               X                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |       X        X                                                         |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                                                    X                     |          1 |
      Leukemia Mononuclear                 |    X                                                           X         |          5 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
      Pineal Gland, Meningioma Malignant   |                               X                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |    +                                                                     |   5        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   5        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Carcinoma       |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                    X                     |          1 |
      Leukemia Mononuclear                 |    X              X  X     X                             X  X  X         |         22 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2|            |
                                           | 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    280                                    | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     L      |
    PPM                                    | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                 +                        |   1        |
      Carcinoma                            |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                 X  X  X                             X  X  X         |         16 |
      Renal Tubule, Stromal Nephroma       |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                     X               |          5 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                    X                     |          1 |
      Leukemia Mononuclear                 | X  X  X           X  X  X  X     X        X              X  X  X  X      |         31 |
      Mesothelioma Malignant               |                                                                      X   |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|             
                                           | 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    830                                    | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    PPM                                    | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                               X                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X           X  X     X                    X  X  X  X  X  X  X     X  X|             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +     +        +                          +  +     +        +  +|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                               X                                          |             
      Leukemia Mononuclear                 |                X                             X        X                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|             
                                           | 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    830                                    | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    PPM                                    | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X        X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                            |             
      Leukemia Mononuclear                 |                X                             X     X  X  X               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X        X  X           X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                 X     X           X  X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Carcinoma                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Adenoma                              |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Pars Distalis, Adenoma               |             X                    X  X                             X     X|             
      Pars Intermedia, Adenoma             |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                    X                     |             
      Follicular Cell, Carcinoma           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |    +                                         +                           |             
      Mesothelioma Malignant               |    X                                         X                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|             
                                           | 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    830                                    | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    PPM                                    | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                                                   X      |             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X     X  X        X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           |    X        X  X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                    X  X  X  X  X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +        +  +        +                    +  +  +  +  +  +        +   |             
      Leukemia Mononuclear                 |                                              X                           |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X        X                    X     X  X  X           X   |             
      Pancreatic, Leukemia Mononuclear     |                X                                X     X  X  X            |             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                    X     X  X     X           X|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                    X     X  X  X  X           X|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|             
                                           | 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    830                                    | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    PPM                                    | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                               X                                          |             
      Leukemia Mononuclear                 |    X           X  X     X        X           X  X  X  X  X  X  X     X  X|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                    X        X  X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                      X   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                      X     X                                             |             
      Subcutaneous Tissue, Fibroma         |                                        X                                 |             
      Subcutaneous Tissue, Histiocytic     |                                                                          |             
          Sarcoma                          |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +        +                       +        +                           |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +        +                       +        +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|             
                                           | 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    830                                    | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    PPM                                    | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X        X                    X     X  X  X  X  X     X   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X     X                    X        X  X  X  X        X|             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X           X               |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X           X  X     X        X           X  X  X  X  X  X  X     X  X|             
      Mesothelioma Malignant               |    X                                         X                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                  X  X                 X                  |          3 |
      Hepatocellular Adenoma               |                                              X                           |          1 |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Leukemia Mononuclear                 | X  X     X        X              X  X  X  X  X        X  X     X     X  X|         27 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +     +           +                                   +     +         |  13        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X        X                  |          5 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant                 |       X                                                                  |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                          X     X                    X         |          9 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X                          X                 X        X         |         10 |
      Pheochromocytoma Malignant           |                X                                                         |          1 |
      Pheochromocytoma Benign              |                   X                                                      |          5 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                   X      |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|  45        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 | X                                   X        X                       X   |          5 |
      Pars Distalis, Adenoma               |                         X     X  X  X                             X      |         10 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |    X        X                       X                                    |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                      X   |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |       +                                                                  |   3        |
      Mesothelioma Malignant               |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                         X                                                |          2 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                           X                              |          2 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                X                                                         |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X  X  X  X     X     X     X  X  X        X  X  X     X  X  X|         37 |
      Interstitial Cell, Adenoma           |    X                          X                 X                        |          7 |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X                          X  X  X  X        X  X     X         |         20 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +                          +                 +  +               |  18        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |          X                                            X                  |          2 |
      Mediastinal, Leukemia Mononuclear    | X        X                          X                 X                  |         11 |
      Pancreatic, Leukemia Mononuclear     | X  X     X                                            X                  |          9 |
      Renal, Leukemia Mononuclear          |                                                          X               |          2 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  48        |
      Leukemia Mononuclear                 | X  X     X                          X        X        X              X   |         14 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                      X     X        X              X   |         13 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X     X        X              X  X  X  X  X        X  X  X  X     X  X|         29 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 | X        X                             X     X        X              X   |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Fibroadenoma                         |                                                                         X|          2 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                                                                      X   |          3 |
      Subcutaneous Tissue, Fibroma         |          X                                                               |          2 |
      Subcutaneous Tissue, Histiocytic     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Sarcoma                          |          X                                                               |          1 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                       +     +           +                     |   8        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |          +                       +     +           +                     |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Leukemia Mononuclear                 |    X     X                          X     X  X        X  X     X     X   |         18 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7|            |
                             DAY ON TEST   | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2|            |
                                           | 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    830                                    | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|     L      |
    PPM                                    | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X                          X     X  X        X  X     X     X   |         19 |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                              X                           |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |          X                                                               |          1 |
      Leukemia Mononuclear                 | X  X     X        X              X  X  X  X  X        X  X  X  X     X  X|         29 |
      Mesothelioma Malignant               |       X                                                                  |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                         X|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cholangiocarcinoma                   |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |             X  X  X     X     X        X        X        X  X  X  X      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +        +                 +              +  +        +     +         |             
      Sarcoma                              |                                                          X               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                                         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X                          X      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X        X              X                                 |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                         X           X        X                           |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                           |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X                          X      |             
      Pars Distalis, Adenoma               | X  X           X           X        X  X                             X  X|             
      Pars Intermedia, Adenoma             |       X                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                                                                    X|             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X           X                                          |             
      Carcinoma                            |                   X                                                      |             
      Leukemia Mononuclear                 |             X                                                            |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X  X        X     X     X     X        X  X  X     X     X        X  X|             
      Interstitial Cell, Adenoma           | X        X  X     X     X     X     X  X           X     X        X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X  X     X              X        X        X  X  X  X      |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +  +        +                    +  +           +     +      |             
      Leukemia Mononuclear                 |             X                                                            |             
      Deep Cervical, Leukemia Mononuclear  |             X                                                            |             
      Iliac, Leukemia Mononuclear          |                                                 X                        |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |             X  X        X                                                |             
      Pancreatic, Leukemia Mononuclear     |                X                                X                 X      |             
      Renal, Leukemia Mononuclear          |             X                                               X     X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                                X                 X      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |             X  X                                X                 X      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X  X     X     X        X        X        X  X  X  X     X|             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |             X  X                       X        X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                   X                                         X            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                                                         X|             
      Squamous Cell Carcinoma              |                                     X                                    |             
      Squamous Cell Papilloma              |                                                 X                        |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |    X  X                             X                             X      |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                               X                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X              X         |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |             +                                                            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X        X              X        X           X  X  X      |             
      Osteosarcoma, Metastatic, Bone       |                               X                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Skin                            |                                  X                                       |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X              X        X              X  X      |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                  +                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                               X         |             
 __________________________________________|__________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X  X     X     X        X        X        X  X  X  X     X|             
 __________________________________________|__________________________________________________________________________|             
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________|__________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|             
                                           | 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|             
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    2500                                   | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    PPM                                    | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________              
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
      Sarcoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cholangiocarcinoma                   |                X                                                         |          1 |
      Hepatocellular Adenoma               |                                           X     X                        |          2 |
      Leukemia Mononuclear                 |                   X           X     X                                X   |         15 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +           +                    +     +     +  +     +      |  15        |
      Sarcoma                              |                                              X                           |          2 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                X                                                         |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                  X   |          5 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X                                      X   |          6 |
      Pheochromocytoma Malignant           |                                        X                                 |          1 |
      Pheochromocytoma Benign              |                   X  X  X                             X  X              X|          9 |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |                         X        X        X              X        X      |         13 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |       X                                                                  |          3 |
      C-Cell, Carcinoma                    |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                     +                                    |   1        |
      Mesothelioma Malignant               |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                          X               |          3 |
      Carcinoma                            |             X                       X                                    |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                 X                             X                  |          3 |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma| X     X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X|         35 |
      Interstitial Cell, Adenoma           |    X     X                                                               |         13 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X           X                                      X   |         13 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                               +              +           +           +   |  11        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                      X   |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                      X   |          1 |
      Mediastinal, Leukemia Mononuclear    |                               X                                      X   |          5 |
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |          4 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          5 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                  X   |          6 |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X           X     X                                X  X|         18 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                      X   |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroadenoma                         | X                                                                        |          3 |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basal Cell Carcinoma                 |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Keratoacanthoma                      |          X                                      X                        |          3 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |       X                                                                  |          2 |
      Trichoepithelioma                    |                                                    X                     |          1 |
      Subcutaneous Tissue, Fibroma         |                                  X                                       |          5 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   2        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +           +                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                   +           +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                  X   |         10 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 05211-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: CHRONIC                                               EMODIN                                          Date: 01/25/01    
Route: DOSED FEED                                                                                                 Time: 12:57:48    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3|            |
                                           | 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1|            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    2500                                   | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     L      |
    PPM                                    | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Skin                            |                                                                          |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |                                           X                              |          2 |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                                                                  |   1        |
      Carcinoma                            |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                  X   |          8 |
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X              X           X     X                                X  X|         18 |
      Mesothelioma Malignant               |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
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