TDMS Study 05211-05 Pathology Tables
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
FINAL#3;REVISION#1
Facility: Southern Research Institute
Chemical CAS #: 518-82-1
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Mixed Cell | 2 1 3 1 1 2 1 2 1 1 |
Mixed Cell Focus | X X |
Necrosis, Focal | 1 4 1 |
Bile Duct, Hyperplasia | |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 3 1 3 1 2 3 3 2 |
Metaplasia, Hepatocyte | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 |
Degeneration, Fatty | 2 2 3 1 1 3 3 |
Hemorrhage | 2 |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 1 3 |
Hypertrophy, Focal | 2 1 2 2 1 4 3 1|
Hypertrophy | 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 2 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 1 3 3 2 3 2 1 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 3 2 1 2 1 1 2 2|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 3 |
Inflammation, Chronic | 2 3 4 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 3 3 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 2 |
Hyperplasia, Cystic | 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 2 2 2 3 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 1 2 1 1 1 2 1 2 2 4 1 2|
Hemorrhage | |
Necrosis | |
Pigmentation | 2 2 2 3 3 3 3 3 3 2 2 3 3 2|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 1 2 3 3 2 3 3 2 2 3 3 2 3 2 2 2 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 4 |
Ulcer | 3 3 |
Epidermis, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 2 3 |
Femur, Osteopetrosis | 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 3 |
Hydrocephalus | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 2| 5| 2| 2| 1| 1| 1| 1| 1| 7| 0| 0| 0| 0| 4| 0| 2| 2| 2| 2| 7| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 2 2 |
Goblet Cell, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Cataract | 4 3 |
Retina, Degeneration | 4 4 |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyaline Droplet | 1 1 1 3 2 1 1 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 1 1 2 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + M + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + M + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 39 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X X X X X X | 18 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X | 3 |
Infiltration Cellular, Mixed Cell | 3 1 1 3 2 | 15 1.7|
Mixed Cell Focus | X X | 4 |
Necrosis, Focal | 2 | 4 2.0|
Bile Duct, Hyperplasia | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 4 4 | 3 3.7|
Kupffer Cell, Pigmentation | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Atrophy | 2 2| 13 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Metaplasia, Hepatocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cardiomyopathy | 1 1 1 2 1 1 3 2 1 1 2 2 2| 22 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 | 6 3.0|
Degeneration, Fatty | 1 2 1 1 2 | 12 1.8|
Hemorrhage | | 1 2.0|
Hyperplasia, Diffuse | 2 | 1 2.0|
Hyperplasia, Focal | 1 | 3 1.7|
Hypertrophy, Focal | 2 3 1 3 | 12 2.1|
Hypertrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + A + + + + + + + +| 47 |
Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 4 2 3 2| 9 2.6|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3| 22 3.0|
Pars Distalis, Hyperplasia, Focal | 1 1 2 2 3 | 13 1.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Ultimobranchial Cyst | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 1 3 2 2 1 2 3 1 2| 21 1.7|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 | 3 2.3|
Inflammation, Chronic | 3 3 | 5 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cyst | 4 3 3 4 3 | 10 3.4|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hydrometra | 4 3 | 5 2.8|
Hyperplasia, Cystic | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia | 3 4 | 5 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Mediastinal, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Ectasia | | 1 2.0|
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 3 2 2 2 2 3 2 2 2 2 | 18 2.2|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hemorrhage | | 2 2.0|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 3 4 2 2 1 1 1 1 1 1| 27 1.7|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Pigmentation | 3 2 2 3 3 3 2 3 2 3 2 3 2 3 2 3| 30 2.6|
|__________________________________________________________________________|____________|
Thymus | + + M + + + I + + + + + + + + + A + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia | 3 3 2 3 3 2 3 2 4 3 2 3 2 2 3 4 3 3 2 3 2 3 4 4| 44 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic | | 1 4.0|
Ulcer | | 2 3.0|
Epidermis, Hyperplasia | 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cranium, Osteopetrosis | 3 3 3 3 | 7 2.9|
Femur, Osteopetrosis | 3 2 4 | 6 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Compression | 3 3 3 3 | 8 3.0|
Hydrocephalus | 3 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hemorrhage | 3 1 | 3 1.7|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 2 2 2 1 1 1 1 1 | 38 1.1|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 3 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Foreign Body | | 1 |
Inflammation, Chronic | 1 2 1 2| 6 1.7|
Goblet Cell, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 1| 6 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1| 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 4| 4| 3| 9| 8| 0| 4| 3| 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 0| 8| 3| 3| |
| 0| 6| 8| 2| 6| 5| 4| 5| 1| 1| 1| 1| 2| 2| 5| 2| 8| 2| 2| 2| 1| 4| 6| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
0 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
PPM | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Eye | + + + | 5 |
Cataract | 3 3 | 4 3.3|
Retina, Degeneration | 4 4 | 4 4.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.0|
Renal Tubule, Hyaline Droplet | 1 1 1 4 1 1 2 2 2 1 2 3 2 2| 22 1.6|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 4 1 1 1| 45 1.2|
Transitional Epithelium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
280 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X |
Eosinophilic Focus | X X X X |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Mixed Cell | 1 1 2 1 3 1 1 2 |
Mixed Cell Focus | X X |
Necrosis, Focal | 2 1 |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Pigmentation | 2 2 |
|__________________________________________________________________________|
Mesentery | + +|
Accessory Spleen | X|
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 3 1 1 2 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
280 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Degeneration, Fatty | 1 2 1 |
Hemorrhage | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 2 1 |
Necrosis | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 4 |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 3 |
Pars Intermedia, Cyst | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
280 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
C-Cell, Hyperplasia | 1 1 2 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 3 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 1 2 |
Hyperplasia, Cystic | 2 |
|__________________________________________________________________________|
Vagina | + M + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 1 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 3 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 1 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
280 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 2 1 1 2 3 1 1 3 1 1 2 1 |
Necrosis | 3 |
Pigmentation | 3 3 3 2 3 3 4 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 3 2 3 3 3 3 3 3 3 3 4 3 1 2 2 2 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Ulcer | 4 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 |
Femur, Osteopetrosis | 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 4| 2| 3| 3| 7| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 4| 2| 2| 5| 2| 6| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 1| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
280 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 2 2 2 1 2 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Cataract | 1 3 |
Retina, Degeneration | 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 3 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyaline Droplet | 1 2 1 2 2 2 2 3 3 2 3 1 2 3 3 2 3 3 3 3 2 2 3 2 1|
Renal Tubule, Pigmentation | 1 1 1 1 2 1 2 4 2 2 2 1 1 1 2 2 2 2 1 1 1 2 2 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X | 10 |
Eosinophilic Focus | X X X X X X| 10 |
Hepatodiaphragmatic Nodule | X X X X X X X| 9 |
Infiltration Cellular, Mixed Cell | 2 2 1 2 | 12 1.6|
Mixed Cell Focus | X X X | 5 |
Necrosis, Focal | 1 1 | 4 1.3|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 3.5|
Kupffer Cell, Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Accessory Spleen | X | 2 |
Fat, Necrosis | 3 2 2 | 4 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 1 2 1 1 3 3 | 15 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 2 1 1 2| 16 1.2|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 | 4 3.0|
Degeneration, Fatty | 2 3 3 1 3 1| 9 1.9|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Focal | 2 2 3 | 3 2.3|
Hypertrophy, Focal | 1 2 3 3 | 7 1.9|
Necrosis | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + M + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 3 3 3 2 3 | 10 3.1|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 | 11 3.0|
Pars Distalis, Hyperplasia, Focal | 3 2 2 3 3 2 3 | 10 2.6|
Pars Intermedia, Cyst | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 2| 9 1.6|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic | 2 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 3 3 4 | 6 3.7|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hydrometra | 3 | 3 2.0|
Hyperplasia, Cystic | 2 3 2 2 | 5 2.2|
|__________________________________________________________________________|____________|
Vagina | + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Infiltration Cellular, Histiocyte | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Mediastinal, Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 2 2.0|
Hemorrhage | 1 | 4 1.3|
Pigmentation | 2 2 2 2 2 2 | 19 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 5 2.0|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 1 2 2 1 2 4 1 1 1 2| 24 1.6|
Necrosis | | 1 3.0|
Pigmentation | 3 3 4 3 3 3 3 2 4 3 3 2 3 2 3 2 | 30 2.9|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 4 3 2 3 3 3 1 2 4 2 3 2 4 3 1 3 4 4 2 3| 44 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Ulcer | | 1 4.0|
Epidermis, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 3 3 3 | 5 3.0|
Femur, Osteopetrosis | 2 2 3 2 2 2| 8 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 3 | 7 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 2 4 1 1 2 1 2 1 1 1| 37 1.3|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 4 | 4 2.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 3 1.7|
Respiratory Epithelium, Hyperplasia | 2 1 | 4 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.0|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| |
| 1| 2| 6| 4| 2| 1| 0| 1| 1| 6| 1| 1| 1| 1| 0| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
280 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 43 1.1|
Renal Tubule, Hyaline Droplet | 1 1 3 1 2 1 1 3 2 2 2 3 2 2 1 2 2 1 2 3 3 1 2 2| 49 2.1|
Renal Tubule, Pigmentation | 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 2 2 1 1 1| 49 1.4|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 3 |
Inflammation, Acute | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X X X X X X X X X |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X X X X X |
Infiltration Cellular, Mixed Cell | 3 1 1|
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 1 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 1 2 2 1 1 2 2 2 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Perforation | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Degeneration, Fatty | 1 2 1 2 3 2 |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | 1 1 2 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 1 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 1 1 2 1 1 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 3 3 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 3 2 2|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 4 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 2 |
Hyperplasia, Cystic | 2 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
Infiltration Cellular, Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Hemorrhage | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 2 2 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 4 2 1 1 1 4 1 1 1 1 1 2 1 3 2 1 1 1|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | |
Pigmentation | 3 2 2 3 3 3 3 2 2 2 3 3 2 2 3 2 2 3|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 4 3 2 3 2 2 3 4 2 3 2 4 1 3 4 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 1 |
Ulcer | 2 3 |
Epidermis, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 3 |
Femur, Osteopetrosis | 3 2 3 |
|__________________________________________________________________________|
Skeletal Muscle | |
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
Hydrocephalus | |
|__________________________________________________________________________|
Peripheral Nerve | + |
Atrophy | |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Infiltration Cellular, Histiocyte | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 3 |
Goblet Cell, Hyperplasia | 2|
Respiratory Epithelium, Hyperplasia | 3 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
Cataract | 3 2 |
Hemorrhage | 3 |
Inflammation, Chronic | |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Glomerulosclerosis | 3 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 6| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 2| 3| 3| 4| 3|
| 2| 5| 2| 2| 7| 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 7| 2| 9| 1| 5| 1| 1| 8| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
830 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Hydronephrosis | 3 |
Infarct | 3 1 |
Inflammation, Chronic | |
Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | 4 |
Renal Tubule, Hyaline Droplet | 2 3 3 3 2 2 3 2 3 3 2 3 3 2 3 2 3 1 3 3 3 3 2 3|
Renal Tubule, Pigmentation | 2 3 2 2 2 2 3 2 3 3 2 3 2 2 3 2 3 3 3 3 3 3 2 3|
Transitional Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Necrosis | 4 |
__________________________________________|__________________________________________________________________________
Page 29
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + I +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X | 41 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X X X X X X X X X | 18 |
Hematopoietic Cell Proliferation | 2 | 2 3.0|
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X X| 7 |
Infiltration Cellular, Mixed Cell | 1 2 1 1 1 1 | 9 1.3|
Mixed Cell Focus | X X X X X | 6 |
Necrosis, Focal | 1 1 | 3 1.0|
Bile Duct, Hyperplasia | 3 2| 4 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 | 2 2.5|
Kupffer Cell, Pigmentation | 2 | 3 1.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 3 2 1 2 2 1 | 18 1.6|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Perforation | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Erosion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 1 1 3 1 2 1 3 1 | 17 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 7 3.0|
Degeneration, Fatty | 3 1 1 2 1 3 1 1 | 14 1.7|
Hyperplasia, Focal | 1 2 2 1 1 2| 8 1.5|
Hypertrophy, Focal | 3 2 1 1 2 1 1 | 12 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + + + + + + + + + + + M + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Pars Distalis, Angiectasis | 3 2 3 | 6 2.5|
Pars Distalis, Cyst | 3 3 3 3 3 3 | 13 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 | 3 2.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 3.0|
C-Cell, Hyperplasia | 2 1 1 1 1 | 11 1.2|
Follicle, Cyst | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 3 | 4 3.0|
Hyperplasia | 1 2 2 3 | 6 2.0|
Inflammation, Chronic | 2 3 2 | 6 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 4 | 6 3.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 | 5 2.2|
Hyperplasia, Cystic | 1 1 | 4 1.5|
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Vagina | + | 3 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 4 3.0|
Infiltration Cellular, Histiocyte | 2 2 1 | 4 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + +| 4 |
Mediastinal, Hemorrhage | 4 | 2 3.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Pancreatic, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 1 2 2 | 6 1.8|
Hemorrhage | 2 | 4 1.8|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Pigmentation | 3 2 3 2 2 2 2 2 2 2 2| 21 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 2 3 1 3 1 2 1 1 1 2 | 31 1.6|
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Pigmentation | 2 4 3 2 3 3 3 3 3 2 4 2 3 2 3 3 3 | 35 2.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 3 2 1 3 3 3 3 4 3 3 4 2 3 2 3 2 3 3 2 2 4| 42 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 2 1 | 4 2.0|
Epidermis, Hyperplasia | 2 3 | 5 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 3 3| 6 2.8|
Femur, Osteopetrosis | 3 2 2 3 | 7 2.6|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 3 3 3 | 10 3.0|
Hydrocephalus | 1 2 2 | 3 1.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 2 1 | 34 1.2|
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 3| 3| 3| 3| 1| 3| 6| 3| 0| 3| 3| 3| 3| 2| 7| 3| 2| 3| 3| 3| 3| 3| 3| 7| |
| 2| 0| 0| 0| 1| 1| 1| 5| 1| 2| 2| 2| 2| 1| 5| 4| 1| 7| 1| 1| 1| 1| 1| 1| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
830 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic | 1 3 1 1 | 5 1.8|
Goblet Cell, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 3 | 4 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 3 | 3 2.7|
Hemorrhage | 3 | 2 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Retina, Degeneration | 2 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Glomerulosclerosis | | 1 3.0|
Hydronephrosis | | 1 3.0|
Infarct | | 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Hyaline Droplet | 2 3 3 2 3 2 3 3 3 2 3 2 2 3 2 2 3 3 3 2 2 2 3 3 4| 49 2.6|
Renal Tubule, Pigmentation | 2 3 3 2 3 2 3 3 2 3 2 2 2 2 2 1 3 3 2 2 2 1 1 2 3| 49 2.4|
Transitional Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Eosinophilic Focus | X X X X X X X X X X X X |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 2|
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X X |
Fat, Necrosis | 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 3 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atrophy | 4 |
Degeneration, Fatty | 1 3 2 1 |
Hyperplasia, Focal | 1 1 1 1 2 |
Hypertrophy, Focal | 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 3 2 3 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 1|
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 2 2 |
Inflammation, Chronic | 2 2 2 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 4 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Hyperplasia, Cystic | 1 2 2|
Inflammation, Chronic | 2 4 |
|__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2|
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 2 |
Hemorrhage | 1 1 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 2 2 2 2 2 2 1 2 3 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Developmental Malformation | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 2 1 1 3 1 1 2 3 1 3 1 2 2 2 3 2|
Pigmentation | 4 2 3 4 3 3 3 3 3 2 2 3 3 3 3 2 3 2 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 3 2 1 4 4 3 1 2 3 3 3 4 3 4 3 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 3 |
Epidermis, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 2 3 3 |
Femur, Osteopetrosis | 3 3 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
Hydrocephalus | 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 2 1 2 1 1 1 2 1 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 3| 7| 5|
DAY ON TEST | 3| 2| 1| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 3| 3| 3| 3| 6| 3| 9|
| 2| 9| 0| 1| 1| 5| 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 0| 0| 0| 0| 0| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2500 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
PPM | 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 2 2 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + |
Cataract | |
Inflammation, Chronic | 3 |
Retina, Degeneration | |
|__________________________________________________________________________|
Zymbal's Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 3 |
Inflammation, Chronic | 2 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyaline Droplet | 3 3 3 3 3 4 3 3 3 3 3 3 3 3 4 3 3 4 4 3 3 3 3 2 3|
Renal Tubule, Hyperplasia, Oncocytic | 2 2 |
Renal Tubule, Pigmentation | 3 3 3 3 3 4 3 3 3 3 3 3 3 3 4 3 3 4 3 3 3 3 3 2 3|
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 40
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + I + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 2 | 4 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X X X X X | 11 |
Eosinophilic Focus | X X X X X X X X X X X X X X X | 27 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hepatodiaphragmatic Nodule | X X X X X | 7 |
Infiltration Cellular, Mixed Cell | 1 3 1 1 1 | 11 1.3|
Mixed Cell Focus | | 1 |
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Necrosis | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 3.5|
Kupffer Cell, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Accessory Spleen | | 2 |
Fat, Necrosis | 3 2 | 5 2.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Atrophy | 2 1 2 1 1 1 | 13 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 | 16 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 3 3 3| 10 3.0|
Atrophy | 3 | 2 3.5|
Degeneration, Fatty | 1 1 2 3 1 3 | 10 1.8|
Hyperplasia, Focal | 1 1 | 7 1.1|
Hypertrophy, Focal | 2 1 1 1 4 3 2 | 10 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 | 3 1.7|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 1 2 1 3 | 5 2.0|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 | 16 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia, Focal | 1 | 5 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 1 1 1 1| 12 1.3|
Follicle, Cyst | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 3.0|
Hyperplasia | 2 | 3 2.0|
Inflammation, Chronic | 3 | 5 2.2|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 4 3 | 7 3.4|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 2 2 2 | 6 2.3|
Hyperplasia, Cystic | 2 2 1 2 | 7 1.7|
Inflammation, Chronic | | 2 3.0|
|__________________________________________________________________________|____________|
Vagina | + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 | 6 2.7|
Infiltration Cellular, Histiocyte | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + | 3 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 | 6 2.2|
Hemorrhage | 1 1 | 4 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 3 2 2 2 2 2 2 2 2 2 3 2 2 2 | 25 2.1|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 3 1 3| 4 2.0|
Pigmentation | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Developmental Malformation | | 1 |
Fibrosis | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | 1 1 2 1 2 2 1 1 1 1 2 1 2 2 4 2 1 2 | 40 1.7|
Pigmentation | 3 2 3 2 2 4 3 2 3 3 2 3 3 3 2 2 4 3 3 2 2 3 3 3| 43 2.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 1 2 3 1 2 1 4 2 3 3 3 4 2 4 2 3 3 2 2 3 3 2| 42 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 1 1 | 3 1.3|
Ulcer | 1 3 | 3 2.3|
Epidermis, Hyperplasia | 3 1 2 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 3 3 3 | 8 2.9|
Femur, Osteopetrosis | 2 2 3 2 | 7 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 | 7 3.0|
Hydrocephalus | 3 3 1 3 | 7 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 5 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1| 32 1.2|
Alveolar Epithelium, Hyperplasia | 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 2 |
Inflammation, Chronic | 1 | 5 1.6|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 5| 1| 0| 4| 1| 3| 3| 3| 3| 0| |
| 9| 2| 2| 2| 2| 1| 1| 1| 4| 1| 2| 2| 7| 2| 2| 7| 6| 3| 6| 8| 2| 2| 2| 1| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
2500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Degeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | M + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 | 3 2.3|
Inflammation, Chronic | 1 | 3 1.7|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 2 1 1 1 1 1 1 1| 49 1.1|
Renal Tubule, Hyaline Droplet | 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 2 3 3 3 3 3 3| 50 3.0|
Renal Tubule, Hyperplasia, Oncocytic | | 2 2.0|
Renal Tubule, Pigmentation | 2 3 3 3 3 4 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3| 50 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 |
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X |
Degeneration, Cystic | 2 3 2 2 2 3 2|
Eosinophilic Focus | X X X X |
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | X X X X |
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 2 4 3 2 1 2 3 2 2 3 4 2 3 4 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 4 4 |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | X |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 1 2 3 1 1 3 3 2 2 |
Metaplasia, Hepatocyte | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Hyperplasia, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Edema | 3 2 |
Ulcer | 4 3 3 4 |
Epithelium, Hyperplasia | 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 2 2 2 2 3 2 2 2 2 1 3 2 3 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3|
Degeneration, Fatty | 1 3 2 2 |
Hyperplasia, Focal | 1|
Hypertrophy, Focal | 3 2 2 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 2 3 3 2 2 3 3 2 2 3 3 3 3 3 2 3|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 2 3 1 2 2 2 2 3|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 |
Inflammation, Chronic | 2 2 2 2 2 2 1 2 1 2 3 2 2 3 |
Epithelium, Hyperplasia | 1 1 1 2 1 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 3 3 |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 3 2 3 3 4 2 |
Hematopoietic Cell Proliferation | 3 3 3 |
Necrosis | 4 |
Pigmentation | 3 |
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 2 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hydrocephalus | |
Necrosis | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 3 1 1 1|
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Chronic | 1 3 3 1 3 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 3 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 4| 2| 7| 5| 1| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 4| 2| 2| 3| 8| 3| 0| 8| 3| 9| 2| 9| 2| 7| 2| 3| 3| 2| 2| 0| 2| 3| 1| 9| 3|
| 6| 9| 9| 0| 6| 0| 6| 4| 0| 9| 2| 0| 9| 2| 9| 0| 0| 5| 9| 0| 9| 0| 7| 7| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Inflammation, Chronic | 2 3 2 2 2 3 2 2 2 2|
Nephropathy | 3 2 2 1 1 3 3 1 2 2 1 3 1 2 1 3 2 2 2 3 2 2 1 2|
Renal Tubule, Hyaline Droplet | 1 1 |
Renal Tubule, Pigmentation | 3 3 2 1 2 1 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2| 5 2.0|
Basophilic Focus | X X X X X X X X X X X | 20 |
Clear Cell Focus | X X X X X X | 7 |
Degeneration, Cystic | | 7 2.3|
Eosinophilic Focus | X X | 6 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | X X| 6 |
Necrosis, Focal | 3 | 2 2.0|
Bile Duct, Hyperplasia | 3 1 2 2 2 3 4 3 2 3 2 2 2 3 2 1 2 2 | 33 2.4|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 3 4.0|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Accessory Spleen | X X X | 4 |
Fat, Necrosis | 4 3 4 3 | 5 3.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 2 3 3 2 1 3 2 2 2 | 23 2.1|
Metaplasia, Hepatocyte | 2 | 1 2.0|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 |
Edema | 4 1| 4 2.5|
Ulcer | 4 3 | 6 3.5|
Epithelium, Hyperplasia | 1 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 3 2 3 3 3 2 3 2 2 2 3 2 1 3| 34 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3| 13 3.0|
Degeneration, Fatty | 1 1 2 | 7 1.7|
Hyperplasia, Focal | 2 2 | 3 1.7|
Hypertrophy, Focal | 1 2 | 6 2.2|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 2 1 1 | 10 1.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 | 5 2.4|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 3 3 3 | 7 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 3 | 6 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 1| 7 1.4|
Follicle, Cyst | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 2 2 3 3 3 3 2 2 3 2 2 | 29 2.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 2 2 2 2 4 2 2 3 | 17 2.2|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2| 5 2.0|
Inflammation, Chronic | 3 4 2 2 3 2 3 2 3 2 2 3 3| 27 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Epithelium, Hyperplasia | 3 1 1 2 1 2 | 12 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 4 4 4 | 7 2.9|
Interstitial Cell, Hyperplasia | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 1.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 2 | 8 2.8|
Hematopoietic Cell Proliferation | | 3 3.0|
Necrosis | | 1 4.0|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + M + I + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 2 2 3 2 2 | 14 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 3 | 2 3.0|
Inflammation, Chronic | 4 1 | 2 2.5|
Epidermis, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3| 4 3.0|
Hydrocephalus | 3| 1 3.0|
Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + M | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 26 1.1|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 3 | 5 2.2|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 9| 2| 3| 2| 2| 3| 1| 2| 1| 2| 3| 7| 2| 2| 0| 3| 0| 2| 2| 2| 3| 3| 2| 1| |
| 0| 0| 8| 0| 9| 9| 0| 6| 9| 1| 9| 0| 9| 9| 9| 4| 0| 4| 9| 9| 9| 0| 0| 9| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
PPM | 9| 0| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Foreign Body | X X | 4 |
Inflammation, Chronic | 3 2 2 | 9 2.2|
Respiratory Epithelium, Hyperplasia | 2 1 2 2 1 | 6 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 4 2.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + | 3 |
Atrophy | | 1 4.0|
Cataract | 2 | 2 2.5|
Retina, Degeneration | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 | 15 2.1|
Nephropathy | 1 2 2 2 3 1 3 1 2 1 1 1 1 3 3 1 2 2 2 1 1 1 2 2| 48 1.8|
Renal Tubule, Hyaline Droplet | 1 | 3 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 2 1 1 1 1| 35 1.3|
Transitional Epithelium, Hyperplasia | 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X X|
Degeneration, Cystic | 1 2 3 |
Eosinophilic Focus | X X X X X|
Hepatodiaphragmatic Nodule | X X X X |
Infiltration Cellular, Mixed Cell | 1 |
Mixed Cell Focus | X |
Necrosis, Focal | 4 2 |
Bile Duct, Hyperplasia | 3 2 4 2 3 4 2 3 3 4 2 3 3|
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 |
Kupffer Cell, Pigmentation | 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Fat, Necrosis | 2 3 3 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 3 4 2 3 2 3 2|
Acinus, Hyperplasia, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 2 |
Ulcer | 3 3 |
Epithelium, Hyperplasia | 2 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | 2 |
Ulcer | 3 3 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 1 2 2 2 3 3 1 1 2 2 1|
Thrombosis | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 3 3 |
Degeneration, Fatty | 2 1 4 3 2 |
Hyperplasia, Diffuse | 4 |
Hypertrophy, Focal | 1 2 3 1 |
Necrosis | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 1 2 2 3 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + M + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 |
Pars Intermedia, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 3 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 2 2 2 2 2 2 3 3 2 2 2 3|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 2 2 2 2 4 3 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 1 1 2 2 3 1 2 2 2 2 2 3 2 1 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 3 2 3|
Interstitial Cell, Hyperplasia | 2 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Pigmentation | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Pancreatic, Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 3 3 2 |
Hematopoietic Cell Proliferation | 1 |
Necrosis | |
Pigmentation | 3 |
|__________________________________________________________________________|
Thymus | + + I + + + + + + + + + + I + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + + + M + + + + + + + + +|
Hyperplasia | 2 3 3 2 3 1 3 2 3 3 2 3 2 4 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 4 |
Hyperplasia, Basal Cell | 3 |
Inflammation, Chronic | 2 |
Ulcer | 4 |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Fibrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hydrocephalus | |
Necrosis | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 3 3 3 2 2 |
Respiratory Epithelium, Hyperplasia | 3 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Zymbal's Gland | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 7| 5| 7| 6| 7| 4| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 9| 7| 2| 6| 3| 1| 1| 9| 5| 2| 0| 7| 1| 7| 1| 2| 0| 3| 3| 3| 2| 3| 3|
| 2| 0| 6| 9| 9| 1| 0| 0| 4| 1| 7| 5| 4| 9| 6| 9| 7| 9| 4| 0| 0| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
280 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic | 2 2 3 2 2 |
Nephropathy | 1 1 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 4 1 3 1 1 2 1 3|
Renal Tubule, Hyaline Droplet | 1 1 1 1 3 3 4 2 1 3 2 3 1 1 4 1 4 3 1 2 2 3|
Renal Tubule, Necrosis | 4 |
Renal Tubule, Pigmentation | 4 4 4 1 3 1 3 1 1 1 3 1 3 2 1 3 1 4 1 1 1 1 3|
Transitional Epithelium, Hyperplasia | 1 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Edema | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Edema | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + I +| 48 |
Congestion | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 5 1.8|
Basophilic Focus | X X X X X X X X X X X| 18 |
Clear Cell Focus | X X X X X | 7 |
Degeneration, Cystic | 1 2 2 1 1 2 1 | 10 1.6|
Eosinophilic Focus | X X X | 8 |
Hepatodiaphragmatic Nodule | X | 5 |
Infiltration Cellular, Mixed Cell | 3 | 2 2.0|
Mixed Cell Focus | X X X | 4 |
Necrosis, Focal | | 2 3.0|
Bile Duct, Hyperplasia | 2 2 3 3 3 2 2 3 2 3 2| 24 2.7|
Centrilobular, Necrosis | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 3.3|
Kupffer Cell, Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Accessory Spleen | X | 2 |
Fat, Necrosis | 3 3 3 | 6 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 3 4 2 3 2 3 | 19 2.6|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 3 2.3|
Ulcer | | 2 3.0|
Epithelium, Hyperplasia | 1 | 4 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 3 2.0|
Erosion | 1 | 2 1.5|
Ulcer | 2 | 3 2.7|
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 2 2 2 3 2 1 1 2 2 1 3 3| 31 1.9|
Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 3 3 | 18 3.0|
Degeneration, Fatty | 1 2 2 1 | 9 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Diffuse | 4 | 2 4.0|
Hypertrophy, Focal | 3 1 2 3 2 | 9 2.0|
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 1 3 | 9 1.9|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + + + + M + +| 45 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 3 3 3 3 | 9 3.0|
Pars Distalis, Hyperplasia, Focal | 2 1 | 3 2.0|
Pars Intermedia, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 | 2 1.5|
Follicle, Cyst | | 3 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 2 2 3 2 2 3 3 3 2 2 2 3| 26 2.4|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 3 3 2 2 2 2 | 20 2.4|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Fibrosis | 2 2 2 2 2 | 5 2.0|
Inflammation, Chronic | 3 3 3 3 2 3 3 2 2 2 | 24 2.2|
Epithelium, Hyperplasia | 1 3 1 | 3 1.7|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 4 2 3 4 2 1 3 | 12 2.6|
Interstitial Cell, Hyperplasia | 1 1 2 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 | 5 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 21 |
Iliac, Pigmentation | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 3 3 | 2 3.0|
Pancreatic, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 3 2.3|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hemorrhage | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 2 3 2 | 9 2.4|
Hematopoietic Cell Proliferation | 1 2 4 3 | 5 2.2|
Necrosis | 4 | 1 4.0|
Pigmentation | 3 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 3 2 3 2 3 3 2 | 23 2.6|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 3 3.7|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
Ulcer | 1 | 2 2.5|
Epidermis, Hyperplasia | 3 3 | 3 2.7|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 3.0|
Hydrocephalus | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 5 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 6| 5| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 8| 2| 6| 9| 0| 3| 2| 2| 2| 3| 3| 6| 6| 2| 5| 7| 1| 2| 3| 2| |
| 0| 0| 1| 9| 0| 4| 9| 5| 0| 6| 0| 9| 9| 9| 0| 0| 2| 4| 9| 5| 3| 1| 9| 6| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
280 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
PPM | 0| 1| 2| 3| 6| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1| 28 1.1|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X X | 3 |
Inflammation, Chronic | 3 3 3 | 8 2.8|
Respiratory Epithelium, Hyperplasia | 3 2 2 | 7 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 2.3|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic | 3 3 2 2 2 2| 11 2.3|
Nephropathy | 3 2 1 3 2 3 2 3 4 1 2 1 1 2 1 2 2 2 1 1 2 1 3 2 3| 50 1.9|
Renal Tubule, Hyaline Droplet | 1 2 3 2 3 3 3 1 1 3 1 1 3 1 2 2 2 1 3 1 1 2 2| 45 2.0|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Pigmentation | 2 1 1 1 1 1 2 3 1 4 1 1 1 1 1 1 1 2 1 3 1 1 2 1| 47 1.8|
Transitional Epithelium, Hyperplasia | 1 2 | 4 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic | 2 2 2 2 2 2|
Eosinophilic Focus | X X|
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 3 4 3 4 3 4 2|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 3 3 |
Kupffer Cell, Pigmentation | 2 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + +|
Accessory Spleen | X X |
Fat, Necrosis | 3 3 3 3 3 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 1 2 1 3 3 |
Metaplasia, Hepatocyte | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + + + + + + +|
Edema | |
Perforation | |
Ulcer | 4 3 |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Erosion | 2 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 1 3 2 2 3 3 2 2 2 2 2 1 2|
Thrombosis | 4 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 3 3|
Degeneration, Fatty | 2 1 2 1 1|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 3 2 2 |
Hypertrophy | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 2 3 3 2 3 2 2 3 3 2 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic | 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Inflammation, Chronic | 2 2 2 2 1 3 2 2 2 3|
Epithelium, Hyperplasia | 2 1 2 2 4 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 4 3 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 4 2 3 |
Renal, Hemorrhage | 4 |
Renal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 3 3 2 |
Necrosis | 3 |
Pigmentation | 3 3 3 |
|__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X X |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3|
Hydrocephalus | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 2 2 1 1|
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 1 3 1 1 |
Respiratory Epithelium, Hyperplasia | 1 3 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic | 2 2 2 3 2 2 |
Nephropathy | 2 2 2 1 1 1 2 3 1 1 3 1 3 3 1 1 2 2 1 2 2 2 2 1 3|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 3| 3| 0| 1| 2| 2| 4| 3| 1| 3| 1| 0| 2| 8| 3| 2| 0| 0| 0| 3| 2| 4| 3|
| 0| 3| 0| 0| 0| 0| 9| 9| 5| 0| 7| 0| 7| 0| 5| 9| 8| 9| 4| 4| 2| 0| 9| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
830 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
PPM | 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 1|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Hyaline Droplet | 2 2 1 1 3 2 1 1 1 2 1 1 2 3 1 1 2 1 1 1 1|
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 3 1 1 3 3 1 1 1 2 2 2 2 1 1 2 1 1 3 2 2 2 2 2 1|
Transitional Epithelium, Hyperplasia | 2 1|
|__________________________________________________________________________|
Urethra | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________
Page 76
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 3 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X| 18 |
Clear Cell Focus | X X X X X X | 9 |
Degeneration, Cystic | 2 1 1 3 1 | 11 1.8|
Eosinophilic Focus | X X X X| 6 |
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Infiltration Cellular, Mixed Cell | 1 2 | 2 1.5|
Mixed Cell Focus | X X X | 3 |
Necrosis, Focal | 1 3 | 2 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 1 3 3 2 4 3 1 3 | 20 2.6|
Hepatocyte, Vacuolization Cytoplasmic| | 4 3.3|
Kupffer Cell, Pigmentation | | 2 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Accessory Spleen | | 2 |
Fat, Necrosis | 3 3 2 3 4 | 11 2.9|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 1 1 3 1 2 2 | 16 1.8|
Metaplasia, Hepatocyte | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 3 | 2 3.0|
Perforation | X | 1 |
Ulcer | 3 3 | 4 3.3|
Epithelium, Hyperplasia | 2 2 2 4 | 7 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 3 2.3|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 3 2 1 2 2 2 2 2 1 2 2 2 2 2 2| 35 2.0|
Thrombosis | 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 | 16 3.0|
Degeneration, Fatty | 2 2 1 1 3 | 10 1.6|
Hyperplasia, Diffuse | 2 | 1 2.0|
Hyperplasia, Focal | 2 1 | 4 1.8|
Hypertrophy, Focal | 2 3 2 1 | 7 2.1|
Hypertrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + I + + + + + + + + + + + + M + M + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 3 3 3 3 | 5 3.0|
Pars Distalis, Hyperplasia, Focal | 1 3 | 5 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 3 | 1 3.0|
C-Cell, Hyperplasia | 1 1 1 2 2 | 7 1.3|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 3 3 3 3 2 3 2 3 2 3 3| 25 2.6|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic | 3 2 2 2 3 2 2 2 3| 13 2.2|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2| 4 2.3|
Inflammation, Chronic | 2 2 3 2 1 2 2 3 2 2 3 2 3 2 2 4 2 3 | 28 2.3|
Epithelium, Hyperplasia | 2 2 2 1 | 10 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 3 | 3 3.3|
Interstitial Cell, Hyperplasia | 1 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 18 |
Mediastinal, Hemorrhage | 3 | 2 3.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Pigmentation | 2 | 4 2.8|
Renal, Hemorrhage | | 1 4.0|
Renal, Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + I + +| 48 |
Ectasia | 2 2 | 2 2.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 1.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 2| 3 2.7|
Hematopoietic Cell Proliferation | 3 | 4 2.8|
Necrosis | 3 | 2 3.0|
Pigmentation | 3 | 4 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hyperplasia | 3 3 2 3 | 10 2.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + I + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | | 3 |
Hyperkeratosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 5 3.0|
Hydrocephalus | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + | 8 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 3 | 2 2.5|
Infiltration Cellular, Histiocyte | 2 3 1 1 1 1 1 1 3 1 2 1 2 1 1| 27 1.4|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic | 3 4 2 4 | 9 2.2|
Respiratory Epithelium, Hyperplasia | 3 3 2 3 2 | 8 2.3|
Respiratory Epithelium, Metaplasia, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 5| 7| 7| 7| 4| 5| 7| 7| 7| 5| 6| 7| 7| 3| 6| 6| 7| 3| 6| 7| 7| |
DAY ON TEST | 7| 2| 4| 3| 7| 2| 2| 3| 8| 3| 3| 3| 2| 5| 4| 2| 2| 6| 0| 9| 3| 7| 0| 2| 2| |
| 3| 4| 4| 1| 5| 9| 9| 0| 3| 3| 0| 0| 0| 0| 5| 9| 9| 8| 5| 6| 0| 3| 9| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
830 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
PPM | 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Squamous | 2 3 2 3 | 5 2.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 3.0|
Inflammation, Chronic | 2 2 3 2 2 2 2| 13 2.2|
Nephropathy | 2 1 2 2 2 2 2 3 3 3 2 2 2 1 1 1 1 1 2 2 2 1 1 1 2| 50 1.8|
Renal Tubule, Hyaline Droplet | 3 1 3 2 2 3 2 2 1 4 1 1 3 1 2 3 3 1 2 1 3 2| 43 1.8|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | 2 3 1 2 2 1 1 1 2 1 1 4 2 1 3 1 2 4 2 1 3 1 2 2| 49 1.8|
Transitional Epithelium, Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +|
Edema | 3 2 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 1 1 |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Degeneration, Cystic | 1 4 2 2 3 3|
Eosinophilic Focus | X X X X X X |
Hepatodiaphragmatic Nodule | X X X |
Infiltration Cellular, Mixed Cell | 2 |
Mixed Cell Focus | X X X X X |
Bile Duct, Hyperplasia | 2 4 3 2 2 2 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 3 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Atrophy | 1 3 4 2 1 1 2 1 3 4 3 4 1|
Acinus, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + M + + + +|
Edema | 3 2 2 3|
Ulcer | 1 |
Epithelium, Hyperplasia | 3 2 2|
|__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + M + + + +|
Erosion | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 2 1 1 2 1 2 1 1 3 2 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 |
Degeneration, Fatty | 1 2 3 3 2|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 2 1 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + I + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 3 3 2 2 2 2 2 2 2 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 2 3 |
Inflammation, Chronic | 2 3 3 2 2 1 1 2 2 2 2 3 3 |
Epithelium, Hyperplasia | 1 4 4 2 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 4 1 4 4 3 4 |
Interstitial Cell, Hyperplasia | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Iliac, Pigmentation | 4 |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Hemorrhage | 4 |
Renal, Pigmentation | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 3 2 |
Hematopoietic Cell Proliferation | 2 3 3 1 |
Necrosis | 4 |
Pigmentation | 3 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 3 3 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Compression | 3 |
Hydrocephalus | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 4 1 2 1 1 1 2 1 1|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 3 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 1 1 3 2 2 3 2 |
Respiratory Epithelium, Hyperplasia | 1 3 2 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 1| 2| 2| 9| 3| 3| 3| 1| 3| 6| 2| 2| 0| 3| 3| 3| 0| 6| 0| 2| 2|
| 0| 0| 0| 9| 1| 9| 9| 2| 9| 0| 0| 1| 0| 8| 9| 9| 2| 0| 0| 0| 0| 6| 5| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
2500 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
PPM | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hydronephrosis | 2 |
Infarct | 3 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 |
Nephropathy | 3 2 3 1 1 1 1 1 2 3 2 4 3 2 2 1 1 1 2 3 1 1 1 3 1|
Renal Tubule, Hyaline Droplet | 2 1 1 3 3 3 2 3 2 2 2 3 1 2 2 1 1 1 2 1 1 2 1|
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 3 2 2 3 3 3 2 1 4 3 2 3 2 1 2 3 1 2 3 3 4 2 1 1 2|
Transitional Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Urethra | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 1 |
__________________________________________|__________________________________________________________________________
Page 88
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 2 2.5|
Inflammation, Chronic | 3 3 | 2 3.0|
Epithelium, Hyperplasia | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 2 2 1 1 | 11 1.7|
Basophilic Focus | X X X X X X X X X X | 23 |
Clear Cell Focus | X X X X X X X| 13 |
Degeneration, Cystic | 2 2 2 1 | 10 2.2|
Eosinophilic Focus | X X X X | 10 |
Hepatodiaphragmatic Nodule | X | 4 |
Infiltration Cellular, Mixed Cell | 2 | 2 2.0|
Mixed Cell Focus | X X X X| 9 |
Bile Duct, Hyperplasia | 3 1 3 2 1 1 | 14 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 2 4.0|
Kupffer Cell, Pigmentation | 2 2 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + + + + + | 15 |
Fat, Necrosis | 3 3 3 3 3 3 3 | 12 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 2 3 2 3 1 2 1 | 23 2.1|
Acinus, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Edema | 3 | 5 2.6|
Ulcer | 2 3 2 | 4 2.0|
Epithelium, Hyperplasia | 3 2 | 5 2.4|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 3 | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 2 1 1 3 2 3 3 3 2 1 2 1 2 3 2 1 2 2| 36 1.9|
Thrombosis | 2 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 | 10 3.0|
Degeneration, Fatty | 1 3 1 | 8 2.0|
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 2 1 2 1 2 2 2 2 1 2| 17 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | | 3 3.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 3.0|
C-Cell, Hyperplasia | 1 1 2 | 4 1.3|
Follicle, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 3 2 2 2 2 3 2 2 3 2 3 3 3 3 2 3 2| 29 2.4|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 | 20 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 6 2.8|
Inflammation, Chronic | 2 2 2 2 1 2 2 3 3 2 2 3 2 3 3 2| 29 2.2|
Epithelium, Hyperplasia | 1 2 3 4 | 9 2.6|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 4 | 8 3.1|
Interstitial Cell, Hyperplasia | 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 3 3 4 3 4 2 2 | 11 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 11 |
Iliac, Pigmentation | | 1 4.0|
Mediastinal, Hemorrhage | 3 4 3 | 4 2.8|
Mediastinal, Pigmentation | 2 | 2 2.0|
Pancreatic, Hemorrhage | | 1 4.0|
Renal, Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 1 2.0|
Hemorrhage | 2 2 | 2 2.0|
Pigmentation | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 3 4 4 4 | 6 3.3|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 3 3.0|
Hematopoietic Cell Proliferation | 2 3 2 2 | 8 2.3|
Necrosis | | 1 4.0|
Pigmentation | 3 3 | 4 3.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 3 1 3 3 | 13 2.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 2 |
Inflammation, Chronic | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Hemorrhage | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Compression | 3 3 3 3 | 5 3.0|
Hydrocephalus | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1| 35 1.2|
Inflammation, Chronic | 3 1| 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 3 | 5 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X| 2 |
Inflammation, Chronic | 3 | 8 2.1|
Respiratory Epithelium, Hyperplasia | | 5 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hydronephrosis | 2 | 2 2.0|
Infarct | 2 3 | 3 2.7|
Inflammation, Chronic | 2 2 3 3 2 2 3 2 2 3 2 2 2 | 25 2.2|
Nephropathy | 1 1 3 3 1 3 2 2 2 3 2 3 1 1 3 2 2 1 2 3 1 2 2 2 2| 50 1.9|
Renal Tubule, Hyaline Droplet | 1 1 1 1 2 1 1 3 2 2 1 3 2 3 1 2 1 1 3 1| 43 1.7|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 2 1 3 2 1 2 2 2 2 2 3 2 3 1 3 2 2 2 1 2 1 2 1 3 2| 50 2.1|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Urethra | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05211-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EMODIN Date: 01/25/01
Route: DOSED FEED Time: 13:02:23
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 0| 2| 2| 1| 3| 5| 3| 3| 0| 2| 4| 1| 3| 2| 2| 3| 9| 3| 2| 2| 2| 3| 9| 3| |
| 0| 2| 9| 9| 7| 4| 4| 1| 1| 7| 0| 5| 7| 0| 9| 9| 1| 0| 1| 9| 9| 9| 1| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
2500 | 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
PPM | 8| 9| 1| 3| 5| 6| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
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---------- END OF REPORT ----------
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