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TDMS Study 05211-06 Pathology Tables

NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99
Route: DOSED FEED                                                                                                 Time: 10:51:14

                                                 CORE STUDY; FINAL#1,REVISION#1




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            9            2            7                                     
    Natural Death                                      6            2            7            7                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           40           36                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (49)         (48)         (48)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (49)         (47)         (46)                                   
      Ectasia                                                       1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                                                                       
   Intestine Small, Jejunum                           (45)         (48)         (45)         (46)                                   
      Edema                                                         1 (2%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (48)         (49)         (47)         (46)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   1 (2%)       2 (4%)       1 (2%)                                
      Basophilic Focus                                                           1 (2%)                                             
      Clear Cell Focus                                              1 (2%)                                                          
      Congestion, Focal                                1 (2%)                    2 (4%)       1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                                                                      1 (2%)                                
      Fibrosis, Focal                                               1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hemorrhage, Focal                                1 (2%)                    1 (2%)       2 (4%)                                
      Hyperplasia, Focal, Histiocytic                  1 (2%)                                                                       
      Hyperplasia, Focal, Lymphoid                                               2 (4%)                                             
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Focal                              5 (10%)      3 (6%)                                                          
      Mineralization, Focal                                         1 (2%)                                                          
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)                    2 (4%)                                
      Pigmentation, Focal                                           1 (2%)                    1 (2%)                                
      Tension Lipidosis                                                                       1 (2%)                                
      Bile Duct, Cyst                                                                         1 (2%)                                
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Fatty Change, Diffuse                1 (2%)       3 (6%)       2 (4%)       4 (8%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal                               1 (2%)                                             
      Hepatocyte, Periportal, Atrophy                  1 (2%)       1 (2%)                                                          
      Hepatocyte, Periportal, Necrosis                              1 (2%)                                                          
      Hepatocyte, Periportal, Regeneration                          1 (2%)                                                          
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                  1 (2%)                                                                       
      Hepatocyte, Centrilobular, Cytomegaly                                                   1 (2%)                                
   Mesentery                                          (14)         (16)         (15)         (11)                                   
      Angiectasis                                                   1 (6%)                                                          
      Inflammation, Chronic                                                                   1 (9%)                                
      Fat, Necrosis                                    7 (50%)     10 (63%)     12 (80%)      6 (55%)                               
   Pancreas                                           (48)         (49)         (49)         (48)                                   
      Lipomatosis                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Acinus, Atrophy, Diffuse                                                   1 (2%)                                             
      Acinus, Atrophy, Focal                           1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Acinus, Focal Cellular Change                                              1 (2%)                                             
      Duct, Cyst                                       3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
   Stomach, Forestomach                               (50)         (49)         (48)         (49)                                   
      Epithelium, Hyperplasia                          1 (2%)                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (49)         (48)         (48)                                   
      Erosion                                                                                 1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                                                                       
      Glands, Degeneration, Cystic, Focal              1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
   Tooth                                                                        (2)                                                 
      Developmental Malformation                                                 1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (4)          (2)          (2)                                    
      Inflammation, Chronic                                         1 (25%)                                                         
      Aorta, Mineralization                                                      1 (50%)      1 (50%)                               
      Pulmonary Artery, Media, Hyperplasia                          3 (75%)                   1 (50%)                               
      Pulmonary Artery, Media, Hypertrophy                          1 (25%)      1 (50%)                                            
   Heart                                              (50)         (50)         (50)         (50)                                   
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)       1 (2%)       1 (2%)                                             
      Angiectasis                                                                             1 (2%)                                
      Cyst                                                                                    2 (4%)                                
      Cytoplasmic Alteration, Focal                                 1 (2%)       2 (4%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Capsule, Hyperplasia, Focal                      1 (2%)                                 1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Parathyroid Gland                                  (44)         (47)         (45)         (47)                                   
      Cyst                                                          3 (6%)                                                          
      Vacuolization Cytoplasmic, Focal                                                        1 (2%)                                
   Pituitary Gland                                    (46)         (45)         (46)         (44)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Pars Distalis, Cyst                                           1 (2%)       1 (2%)                                             
      Pars Distalis, Cytoplasmic Alteration, Focal     2 (4%)       2 (4%)       3 (7%)       3 (7%)                                
      Pars Distalis, Hyperplasia, Focal                3 (7%)       1 (2%)       3 (7%)       3 (7%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (48)                                   
      Cyst                                                                                    1 (2%)                                
      Degeneration, Cystic, Focal                     14 (28%)      1 (2%)       5 (10%)      9 (19%)                               
      Inflammation, Chronic, Focal                     2 (4%)                    1 (2%)                                             
      C-Cell, Hyperplasia                                                                     1 (2%)                                
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     9 (18%)     11 (22%)     20 (40%)      8 (17%)                               
      Follicular Cell, Hyperplasia, Diffuse                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)                                                                           
      Mesothelium, Hyperplasia, Focal                  1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (48)         (50)         (49)                                   
      Degeneration, Cystic                             1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Ovary                                              (45)         (44)         (48)         (48)                                   
      Angiectasis                                      3 (7%)                    4 (8%)       2 (4%)                                
      Cyst                                            16 (36%)     11 (25%)     11 (23%)     11 (23%)                               
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Thrombosis                                       1 (2%)                                                                       
      Bilateral, Cyst                                                            1 (2%)                                             
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Atrophy                                                       1 (2%)                                                          
      Cyst                                                                                    2 (4%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hydrometra                                      17 (34%)     16 (32%)     13 (27%)     13 (26%)                               
      Inflammation, Suppurative                                                               1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Lymphangiectasis                                                           1 (2%)                                             
      Cervix, Hyperplasia                              1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                47 (94%)     45 (90%)     48 (98%)     45 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Depletion Cellular                                            1 (2%)                                                          
      Hyperplasia                                      3 (6%)       1 (2%)       1 (2%)       5 (10%)                               
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
   Lymph Node                                         (8)          (7)          (9)          (7)                                    
      Bronchial, Hyperplasia                           1 (13%)                                                                      
      Iliac, Angiectasis                                                                      2 (29%)                               
      Iliac, Hyperplasia                                            1 (14%)                                                         
      Inguinal, Hyperplasia, Lymphoid                                                         1 (14%)                               
      Mediastinal, Angiectasis                                                                1 (14%)                               
      Mediastinal, Hyperplasia                                                                1 (14%)                               
      Pancreatic, Hyperplasia, Lymphoid                1 (13%)                   1 (11%)                                            
      Renal, Angiectasis                                                                      1 (14%)                               
      Renal, Hyperplasia                                            1 (14%)                   1 (14%)                               
   Lymph Node, Mandibular                             (48)         (46)         (47)         (47)                                   
      Angiectasis                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Lymph Node, Mesenteric                             (49)         (48)         (50)         (49)                                   
      Angiectasis                                                   1 (2%)                    2 (4%)                                
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                                                              2 (4%)                                
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Spleen                                             (48)         (49)         (49)         (49)                                   
      Angiectasis                                                   1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 9 (19%)     14 (29%)     17 (35%)     16 (33%)                               
      Hyperplasia, Lymphoid                            9 (19%)     10 (20%)     10 (20%)     12 (24%)                               
      Pigmentation, Focal                                                        1 (2%)                                             
   Thymus                                             (49)         (49)         (46)         (48)                                   
      Atrophy                                                                    1 (2%)                                             
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
      Inflammation                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)         (50)                                   
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia                                      2 (4%)                    1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Subcutaneous Tissue, Edema                       1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hyperplasia, Focal,                                                                                      
           Mast Cell                                                1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                       1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                                                                  1 (2%)                                
      Hyperostosis                                     1 (2%)                                                                       
      Osteoporosis                                                  1 (2%)                                                          
   Skeletal Muscle                                    (2)                       (2)          (3)                                    
      Hemorrhage, Focal                                                          1 (50%)                                            
      Inflammation, Suppurative                                                               1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Atrophy, Focal                                   1 (2%)                    1 (2%)       3 (6%)                                
      Demyelination, Focal                                          1 (2%)                                                          
      Gliosis, Focal                                                1 (2%)                                                          
      Hemorrhage, Focal                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 2 (4%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (2%)                    1 (2%)                                
      Bronchus, Glands, Cyst                                                     1 (2%)                                             
      Mediastinum, Infiltration Cellular, Mixed                                                                                     
          Cell                                                                                1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0            312          625          1250                                      
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Cataract                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
      Atrophy, Focal                                   1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
      Metaplasia, Focal, Osseous                                    2 (4%)       2 (4%)                                             
      Nephropathy                                     22 (45%)     46 (92%)     41 (82%)     48 (98%)                               
      Pelvis, Dilatation                                            1 (2%)                                                          
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Renal Tubule, Dilatation                                                                1 (2%)                                
      Renal Tubule, Pigmentation                                   37 (74%)     48 (96%)     49 (100%)                              
      Renal Tubule, Epithelium, Pigmentation                                                  1 (2%)                                
   Urinary Bladder                                    (49)         (50)         (49)         (48)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            7            4                                                  
    Moribund Sacrifice                                 4            6            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           37           40           43                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (46)         (50)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (46)         (49)         (50)                                   
      Inflammation, Focal                                                                     2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (49)         (50)         (50)                                   
      Inflammation, Focal                              1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                 2 (4%)                                 2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                    4 (8%)                                
      Congestion, Focal                                                                       1 (2%)                                
      Eosinophilic Focus                               7 (14%)                   1 (2%)       2 (4%)                                
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Focal                              1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Focal                                               4 (8%)       2 (4%)       2 (4%)                                
      Centrilobular, Vacuolization Cytoplasmic                      1 (2%)                                                          
      Hepatocyte, Fatty Change, Diffuse                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic, Focal    13 (26%)     10 (20%)      7 (14%)      6 (12%)                               
   Mesentery                                          (2)          (4)          (6)          (5)                                    
      Inflammation, Chronic                                                      1 (17%)      1 (20%)                               
      Fat, Necrosis                                    2 (100%)     2 (50%)      1 (17%)      1 (20%)                               
   Pancreas                                           (49)         (50)         (50)         (50)                                   
      Atrophy, Focal                                                1 (2%)                                                          
      Lipomatosis                                                                             1 (2%)                                
      Lipomatosis, Focal                               1 (2%)                                                                       
      Acinus, Atrophy, Focal                                                     1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Vacuolization Cytoplasmic                        1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Cyst                                                           1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)       1 (2%)       3 (6%)                                
      Serosa, Hemorrhage                                                                      1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Erosion                                          1 (2%)                    1 (2%)                                             
      Inflammation, Focal                                                                     1 (2%)                                
      Pigmentation, Focal                                                        1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
      Glands, Degeneration, Cystic, Focal              1 (2%)       3 (6%)       5 (10%)      1 (2%)                                
      Glands, Dysplasia, Focal                                      1 (2%)                                                          
   Tooth                                              (12)         (17)         (18)         (10)                                   
      Developmental Malformation                      12 (100%)    16 (94%)     18 (100%)    10 (100%)                              
      Inflammation, Chronic, Suppurative                                         2 (11%)                                            
      Epithelium Alveolus, Hyperplasia                              1 (6%)                                                          
      Peridontal Tissue, Inflammation, Chronic                      1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)          (1)                                                 
      Inflammation, Chronic                                         1 (100%)                                                        
      Aorta, Inflammation, Chronic                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)       1 (2%)                    1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                                 4 (8%)       1 (2%)       3 (6%)                                
      Hyperplasia, Focal                               3 (6%)                                                                       
      Hypertrophy, Focal                               2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Capsule, Hemorrhage                                                                     1 (2%)                                
      Capsule, Hyperplasia, Focal                      2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)       2 (4%)                    1 (2%)                                
   Islets, Pancreatic                                 (49)         (50)         (50)         (50)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (44)         (47)         (46)         (45)                                   
      Cyst                                             1 (2%)       4 (9%)       1 (2%)                                             
   Pituitary Gland                                    (40)         (38)         (42)         (46)                                   
      Pars Distalis, Cyst                              1 (3%)       2 (5%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic, Focal                      3 (6%)       6 (12%)      8 (16%)      4 (8%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Follicle, Cyst                                   2 (4%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Hyperplasia                    11 (22%)      6 (12%)     16 (32%)     18 (36%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (2)                                                 
      Abdominal, Hemorrhage                                                      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Hypertrophy                                                                             1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Preputial Gland                                    (47)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Degeneration, Cystic                            15 (32%)     21 (42%)     24 (48%)     24 (48%)                               
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
      Inflammation, Chronic                            8 (17%)      6 (12%)      2 (4%)       2 (4%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Dilatation                                      28 (56%)     25 (50%)     18 (36%)     19 (38%)                               
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Hypoplasia                                                                              1 (2%)                                
      Germinal Epithelium, Degeneration                1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
   Lymph Node                                         (6)          (3)          (4)          (1)                                    
      Iliac, Hyperplasia                               1 (17%)                                                                      
      Inguinal, Hyperplasia, Lymphoid                               1 (33%)                                                         
      Inguinal, Infiltration Cellular, Mast Cell       1 (17%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid                                         1 (25%)                                            
      Pancreatic, Hyperplasia                                                    1 (25%)                                            
      Pancreatic, Hyperplasia, Lymphoid                                          1 (25%)                                            
      Renal, Hyperplasia                               1 (17%)                                                                      
   Lymph Node, Mesenteric                             (49)         (46)         (50)         (49)                                   
      Angiectasis                                                                             1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       7 (14%)      4 (9%)       3 (6%)       5 (10%)                               
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Hyperplasia, Histiocytic                         1 (2%)                                 3 (6%)                                
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)       2 (4%)                                
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Depletion Cellular                                                         1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                13 (26%)     14 (28%)     14 (28%)     10 (20%)                               
      Hyperplasia, Lymphoid                                         4 (8%)       3 (6%)       2 (4%)                                
   Thymus                                             (42)         (45)         (46)         (39)                                   
      Atrophy                                                                                 1 (3%)                                
      Cyst                                             2 (5%)       4 (9%)       3 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Subcutaneous Tissue, Angiectasis, Focal                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (50)                                   
      Hemorrhage, Focal                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    3 (6%)                    2 (4%)                                
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       1 (2%)       4 (8%)                                             
      Bronchus, Glands, Cyst                           1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
      Mucosa, Glands, Dilatation, Focal                1 (2%)                                                                       
      Nasolacrimal Duct, Cyst                          1 (2%)                                                                       
      Squamous Epithelium, Nasolacrimal Duct,                                                                                       
          Hyperplasia, Focal                                                     1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05211-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               EMODIN                                          Date: 04/07/99  
Route: DOSED FEED                                                                                                 Time: 10:51:14  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0            160          312          625                                       
                                                   PPM          PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (2)                                    
      Atrophy                                                                                 1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Congestion                                                                              1 (2%)                                
      Cyst                                                          4 (8%)       3 (6%)       3 (6%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Metaplasia, Focal, Osseous                                                 2 (4%)       1 (2%)                                
      Nephropathy                                     49 (100%)    49 (98%)     50 (100%)    49 (98%)                               
      Pelvis, Dilatation                               3 (6%)       3 (6%)       1 (2%)       6 (12%)                               
      Renal Tubule, Accumulation, Hyaline Droplet                                             1 (2%)                                
      Renal Tubule, Degeneration                                                              1 (2%)                                
      Renal Tubule, Dilatation                                                                3 (6%)                                
      Renal Tubule, Hyperplasia, Focal                 1 (2%)                                                                       
      Renal Tubule, Pigmentation                                   46 (92%)     50 (100%)    50 (100%)                              
      Renal Tubule, Epithelium, Pigmentation                                     1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                    2 (4%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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