Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/2802

TDMS Study 05211-06 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     

LAB: Southern Research Inst                                      EMODIN                                        DATE: 12/02/98       

EXPERIMENT: 05211 TEST: 06                                                                                     TIME: 13:48:11       

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        

CONT: NO1-ES-85216                              ROUTE: DOSED FEED                                              NTP C#: C62408       

PATHOLOGIST: FARNELL, D.                                                                                       CAS: 518-82-1        

------------------------------------------------------------------------------------------------------------------------------------

                                                                                                                                    

                                                          CORE STUDY MICE                                                           

                                                                                                                                    


               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      

                                       25019 Moribund Sacrifice                                                                     

                                       25020 Natural Death                                                                          

                                       25021 Terminal Sacrifice                                                                     

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

               REMOVAL DATE RANGE:     ALL                                                                                          

                                                                                                                                    

               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    

LAB: Southern Research Inst                                      EMODIN                                        DATE: 12/02/98      

EXPERIMENT: 05211 TEST: 06                                                                                     TIME: 13:48:11      

TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       

CONT: NO1-ES-85216                              ROUTE: DOSED FEED                                              NTP C#: C62408      

PATHOLOGIST: FARNELL, D.                                                                                       CAS: 518-82-1       
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 729 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 0       PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      556   636   636   639   639   656   680   699   728                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 160     PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      446   461   554   631   632   636   639   645   677   695                 |

 |      699   705   715                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 312     PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      497   541   572   579   581   639   688   688   726   727                 |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 729 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 625     PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 43        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      281   604   632   633   684   723   725                                   |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                     MALE MICE

                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   729 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |0       PPM|   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  88.0  82.0      |

 |           |                                                                    |

 |           |                                                                    |

 |160     PPM|   100.0 100.0 100.0 100.0 100.0  96.0  96.0  94.0  84.0  74.0      |

 |           |                                                                    |

 |           |                                                                    |

 |312     PPM|   100.0 100.0 100.0 100.0 100.0 100.0  96.0  90.0  88.0  80.0      |

 |           |                                                                    |

 |           |                                                                    |

 |625     PPM|   100.0 100.0 100.0  98.0  98.0  98.0  98.0  96.0  92.0  86.0      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                0       PPM  160     PPM  312     PPM  625     P|M

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       82.0%        74.0%        80.0%        86.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.471N     P=0.428      P=0.949      P=0.796N |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       652.1        625.8        623.8        611.7    |

 |NATURAL DEATHS (C)      |       (16.2)       (24.3)       (25.6)       (57.9)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       715.2        702.2        708.0        712.6    |

 |(STANDARD ERROR)        |       ( 5.0)       ( 8.9)       ( 7.8)       ( 9.6)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 731 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 0       PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      484   541   548   587   592   606   608   643   645   681                 |

 |      684   699   721                                                           |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 312     PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      391   461   490   527   552   633   659   681   707   720                 |

 |      727                                                                       |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                DOSE = 625     PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 1    TERMINAL 40        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      461   625   658   673   698   719   720   730   730                       |

 |  CENSORED DEATHS                                                               |

 |      90                                                                        |

 |                                                                                |

 ==================================================================================
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 731 DAYS

                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)

 ==================================================================================

 |                                DOSE = 1250    PPM                              |

 |                             ---------------------                              |

 |                                                                                |

 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |

 |                                                                                |

 |  UNCENSORED DEATHS                                                             |

 |      445   515   525   604   608   646   670   680   681   681                 |

 |      693   695   709   724                                                     |

 |  CENSORED DEATHS                                                               |

 |      NONE                                                                      |

 |                                                                                |

 ==================================================================================
                                      EMODIN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA

                                    FEMALE MICE

                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================

 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |    DOSE                               TIME (DAYS)                              |

 |                 90   180   270   365   425   485   545   605   665   731 (A)   |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |           |                                                                    |

 |0       PPM|   100.0 100.0 100.0 100.0 100.0  98.0  96.0  90.0  82.0  74.0      |

 |           |                                                                    |

 |           |                                                                    |

 |312     PPM|   100.0 100.0 100.0 100.0  98.0  96.0  92.0  90.0  86.0  78.0      |

 |           |                                                                    |

 |           |                                                                    |

 |625     PPM|   100.0 100.0 100.0 100.0 100.0  98.0  98.0  98.0  93.9  81.6      |

 |           |                                                                    |

 |           |                                                                    |

 |1250    PPM|   100.0 100.0 100.0 100.0 100.0  98.0  94.0  92.0  88.0  72.0      |

 |           |                                                                    |

 |           |                                                                    |

 ==================================================================================

 ==================================================================================

 |                           SURVIVAL SUMMARY STATISTICS                          |

 |                                                                                |

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |                                                  DOSE                          |

 |                                                                                |

 |                                0       PPM  312     PPM  625     PPM  1250    P|M

 |                                                                                |

 |--------------------------------------------------------------------------------|

 |SURVIVAL AT END OF STUDY|       74.0%        78.0%        81.6%        72.0%    |

 |(KAPLAN-MEIER)          |                                                       |

 |                        |                                                       |

 |SIGNIFICANCE (B)        |       P=0.880      P=0.805N     P=0.405N     P=1.000  |

 |(LIFE TABLE)            |                                                       |

 |                        |                                                       |

 |MEAN DAY OF             |       618.4        595.3        668.2        634.0    |

 |NATURAL DEATHS (C)      |       (19.2)       (35.1)       (28.6)       (22.5)   |

 |(STANDARD ERROR)        |                                                       |

 |                        |                                                       |

 |MEAN LIFE SPAN (D)      |       701.7        701.1        706.9        703.8    |

 |(STANDARD ERROR)        |       ( 8.6)       (10.9)       (13.9)       ( 8.7)   |

 |                        |                                                       |

 ==================================================================================

                                    


       (A)  FIRST TERMINAL SACRIFICE

       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.

            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS

            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".

       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE

       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                               EMODIN

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        0       PPM      = 1

                                                        160     PPM      = 2

                                                        312     PPM      = 3

                                                        625     PPM      = 4



------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                                            4                        2       3         1

      |

      |                                              4                        2  2    3       3 1       4   1

      |

   96 +                                                                          2            3 2 3     4   4

      |

P     |                                                                                         2 33        11

E     |

R  92 +                                                                                                     4       4

C     |

E     |                                                                                            3         1 1    4     4

N     |

T  88 +                                                                                                     22 1    13

      |

S     |                                                                                                      22     1 1   4 4

U     |

R  84 +                                                                                                       2    2 31   1

V     |

I     |                                                                                                            2  2   1 1

V     |

A  80 +                                                                                                                   3 3

L     |

      |                                                                                                               22

      |

   76 +                                                                                                                2 2

      |

      |                                                                                                                  2  2

      |

   72 +

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 7 obs hidden.
                                                               EMODIN

                                                    KAPLAN-MEIER SURVIVAL CURVES

                                                        0       PPM      = 1

                                                        312     PPM      = 2

                                                        625     PPM      = 3

                                                        1250    PPM      = 4



----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------



                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.



      |

      |

  100 + 1                                                             2       4  3   1

      |

      |                                                               2       4  2   1   4    1            3

      |

   96 +                                                                          2   2   4 4  11           3   3

      |

P     |                                                                              2     42  1    1   4      3   3

E     |

R  92 +                                                                                     2  2    1 1            3  3

C     |

E     |                                                                                        2      1 1   2 4       3  3

N     |

T  88 +                                                                                                     2 4  24

      |

S     |                                                                                                 1    1   24 2    3  3

U     |

R  84 +                                                                                                      11     2  2

V     |

I     |                                                                                                       1     1  2 2  3

V     |

A  80 +                                                                                                             44   22

L     |

      |                                                                                                             141   2 2

      |

   76 +                                                                                                               1 41

      |

      |                                                                                                                 414 1

      |

   72 +                                                                                                                   4 4

      |

      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--

        0         10         20         30         40         50         60         70         80         90         100        110



                                                                   WEEK



NOTE: 8 obs hidden.