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TDMS Study 05211-07 Pathology Tables

NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99
Route: DOSED FEED                                                                                                 Time: 10:52:03

                                                   53 WEEK SPECIAL STUDY RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  518-82-1

       Lock Date:  07/30/97

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    0                                      | 3| 3| 3| 3| 3|                                                           |      L     |
    PPM                                    | 1| 2| 3| 4| 5|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X     X  X  X                                                            |      4     |
      Bile Duct, Hyperplasia               |          2                                                               |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          |       1  1  1                                                            |      3  1.0|
      Renal Tubule, Hyaline Droplet        |    1     2  2                                                            |      3  1.7|
      Renal Tubule, Pigmentation           | 1  1  1  2  2                                                            |      5  1.4|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    280                                    | 3| 3| 3| 3| 4|                                                           |      L     |
    PPM                                    | 6| 7| 8| 9| 0|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X                                                                        |      1     |
      Infiltration Cellular, Mixed Cell    |             3                                                            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1                                                                  |      3  1.0|
      Renal Tubule, Hyaline Droplet        | 3  3  2  3  2                                                            |      5  2.6|
      Renal Tubule, Pigmentation           | 2  2  2  2  2                                                            |      5  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    830                                    | 4| 4| 4| 4| 4|                                                           |      L     |
    PPM                                    | 1| 2| 3| 4| 5|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     |    X     X                                                               |      2     |
      Infiltration Cellular, Mixed Cell    |             1                                                            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1     1  1  1                                                            |      4  1.0|
      Renal Tubule, Hyaline Droplet        | 3  2  3  2  2                                                            |      5  2.4|
      Renal Tubule, Pigmentation           | 2  2  2  1  2                                                            |      5  1.8|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    2500                                   | 4| 4| 4| 4| 5|                                                           |      L     |
    PPM                                    | 6| 7| 8| 9| 0|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     |    X  X  X  X                                                            |      4     |
      Infiltration Cellular, Mixed Cell    |       1                                                                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1     1                                                            |      4  1.0|
      Renal Tubule, Hyaline Droplet        | 3  3  3  3  3                                                            |      5  3.0|
      Renal Tubule, Pigmentation           | 3  3  3  3  3                                                            |      5  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    0                                      | 1| 1| 1| 1| 1|                                                           |      L     |
    PPM                                    | 1| 2| 3| 4| 5|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     |          X                                                               |      1     |
      Infiltration Cellular, Mixed Cell    |    1        1                                                            |      2  1.0|
      Bile Duct, Hyperplasia               | 1                                                                        |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Inflammation, Chronic                |          1                                                               |      1  1.0|
      Nephropathy                          | 1  1  1  2  1                                                            |      5  1.2|
      Renal Tubule, Pigmentation           | 1  1  1  1  1                                                            |      5  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        


                                                             Page   6                                                               
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    280                                    | 1| 1| 1| 1| 2|                                                           |      L     |
    PPM                                    | 6| 7| 8| 9| 0|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1  2  1                                                            |      5  1.2|
      Renal Tubule, Hyaline Droplet        | 2  2  3  2  2                                                            |      5  2.2|
      Renal Tubule, Pigmentation           | 1  1  1  1  1                                                            |      5  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    830                                    | 2| 2| 2| 2| 2|                                                           |      L     |
    PPM                                    | 1| 2| 3| 4| 5|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X                                                                        |      1     |
      Infiltration Cellular, Mixed Cell    |       1                                                                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1  2  1                                                            |      5  1.2|
      Renal Tubule, Hyaline Droplet        | 3  1  3  3  3                                                            |      5  2.6|
      Renal Tubule, Pigmentation           | 1  1  1  1  1                                                            |      5  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    2500                                   | 2| 2| 2| 2| 3|                                                           |      L     |
    PPM                                    | 6| 7| 8| 9| 0|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     |    X                                                                     |      1     |
      Infiltration Cellular, Mixed Cell    |          1                                                               |      1  1.0|
      Mixed Cell Focus                     |    X                                                                     |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
      Nephropathy                          | 1  1  1  1  2                                                            |      5  1.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05211-07                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               EMODIN                                          Date: 01/08/99  
Route: DOSED FEED                                                                                                 Time: 10:52:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 5| 5| 5| 5| 5|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    2500                                   | 2| 2| 2| 2| 3|                                                           |      L     |
    PPM                                    | 6| 7| 8| 9| 0|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyaline Droplet        | 3  2  3  3  3                                                            |      5  2.8|
      Renal Tubule, Pigmentation           | 2     1  1  1                                                            |      4  1.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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