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TDMS Study 05212-03 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              OXAZEPAM


NTP Experiment-Test: 05212-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 09:53:46




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  02/20/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3            2           26           35                                     
    Moribund Sacrifice                                 8            7           22           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           41            2                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatoblastoma                                                1 (2%)       8 (13%)      9 (15%)                               
      Hepatoblastoma, Multiple                                                                1 (2%)                                
      Hepatocellular Carcinoma                        10 (17%)      4 (7%)       9 (15%)      4 (7%)                                
      Hepatocellular Carcinoma, Multiple                            1 (2%)      42 (70%)     50 (83%)                               
      Hepatocellular Adenoma                          13 (22%)     17 (28%)      6 (10%)      6 (10%)                               
      Hepatocellular Adenoma, Multiple                13 (22%)     19 (32%)     38 (63%)     40 (67%)                               
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
   Mesentery                                          (3)          (3)                                                              
      Histiocytic Sarcoma                                           1 (33%)                                                         
      Teratoma Malignant, Metastatic, Ovary            1 (33%)                                                                      
      Fat, Lipoma                                      1 (33%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Capsule, Adenoma                                              1 (2%)                                                          
      Capsule, Histiocytic Sarcoma                                  1 (2%)                                                          
   Pituitary Gland                                    (60)         (59)         (53)         (59)                                   
      Pars Distalis, Adenoma                           3 (5%)       9 (15%)                                                         
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Follicular Cell, Adenoma                                      4 (7%)       5 (8%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)         (60)         (58)         (60)                                   
      Cystadenoma                                      1 (2%)       3 (5%)       1 (2%)                                             
      Granulosa Cell Tumor Malignant                   1 (2%)                                                                       
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Luteoma                                          2 (3%)                                                                       
      Teratoma Malignant                               1 (2%)       1 (2%)                                                          
      Follicle, Adenoma                                1 (2%)                    2 (3%)                                             
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    1 (2%)                    1 (2%)                                             
      Cervix, Histiocytic Sarcoma                      1 (2%)                    1 (2%)                                             
      Endometrium, Carcinoma                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (3)          (2)          (1)                                                 
      Pancreatic, Histiocytic Sarcoma                               1 (50%)                                                         
      Renal, Teratoma Malignant, Metastatic, Ovary     1 (33%)                                                                      
      Thoracic, Histiocytic Sarcoma                                 1 (50%)                                                         
   Lymph Node, Bronchial                              (1)                                                                           
   Lymph Node, Mandibular                             (58)         (57)         (58)         (54)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (58)         (56)         (48)         (47)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Teratoma Malignant, Metastatic, Ovary            1 (2%)                                                                       
   Lymph Node, Mediastinal                            (1)          (2)          (3)                                                 
      Histiocytic Sarcoma                                           1 (50%)                                                         
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Thymus                                             (60)         (58)         (44)         (43)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Thymoma NOS                                      1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Melanoma NOS                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Diaphragm, Teratoma Malignant, Metastatic,                                                                                    
           Ovary                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     3 (5%)       1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       3 (5%)       1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                          2 (3%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (5%)       2 (3%)       8 (13%)     10 (17%)                               
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Teratoma Malignant, Metastatic, Ovary            1 (2%)                                                                       
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)          (1)                                                 
      External Ear, Fibrosarcoma                                                 1 (100%)                                           
   Harderian Gland                                    (3)          (3)          (1)          (1)                                    
      Adenoma                                          1 (33%)      3 (100%)     1 (100%)     1 (100%)                              
      Carcinoma                                        1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           2 (3%)                                                          
      Teratoma Malignant, Metastatic, Ovary            1 (2%)                                                                       
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       2 (3%)       1 (2%)                                             
      Lymphoma Malignant                                                         1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   2 (3%)       2 (3%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         1 (2%)       1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          45          59          57                                       
     Total Primary Neoplasms                           63          77         122         118                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 31          42          47          48                                       
     Total Benign Neoplasms                            41          59          55          54                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          15          52          54                                       
     Total Malignant Neoplasms                         21          17          66          64                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           2           8          12                                       
     Total Metastatic Neoplasm                         12           2          10          12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1                                                   
     Total Uncertain Neoplasms                          1           1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            4           22           30                                     
    Natural Death                                      3            2           13           20                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           44           15                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (60)         (54)         (32)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Intestine Large, Colon                             (59)         (60)         (60)         (59)                                   
   Intestine Small, Duodenum                          (59)         (60)         (59)         (60)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Liver                                              (59)         (60)         (60)         (60)                                   
      Hemangiosarcoma, Multiple                        1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
      Hepatoblastoma                                                2 (3%)      20 (33%)     13 (22%)                               
      Hepatoblastoma, Multiple                                                   1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma                         8 (14%)      4 (7%)       7 (12%)      6 (10%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       2 (3%)      42 (70%)     53 (88%)                               
      Hepatocellular Adenoma                          10 (17%)     12 (20%)      7 (12%)      5 (8%)                                
      Hepatocellular Adenoma, Multiple                 7 (12%)      9 (15%)     36 (60%)     36 (60%)                               
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Kidney                                                1 (2%)                                             
   Mesentery                                          (2)          (2)          (2)          (2)                                    
      Histiocytic Sarcoma                              1 (50%)      1 (50%)                                                         
      Fat, Hepatocellular Carcinoma, Metastatic,                                                                                    
           Liver                                                                 1 (50%)                                            
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (59)         (60)                                   
      Adenoma                                                                    1 (2%)                                             
      Capsule, Adenoma                                 6 (10%)      4 (7%)                                                          
      Capsule, Hepatoblastoma, Metastatic, Liver                                 1 (2%)                                             
      Capsule, Histiocytic Sarcoma                     1 (2%)                                                                       
   Adrenal Medulla                                    (59)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Pituitary Gland                                    (58)         (60)         (52)         (47)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
   Thyroid Gland                                      (59)         (60)         (60)         (60)                                   
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Prostate                                           (59)         (60)         (60)         (60)                                   
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (2)          (1)          (1)          (2)                                    
      Lumbar, Histiocytic Sarcoma                      1 (50%)                                                                      
      Popliteal, Histiocytic Sarcoma                                1 (100%)                                                        
      Renal, Hepatoblastoma, Metastatic, Liver                                   1 (100%)                                           
   Lymph Node, Mandibular                             (54)         (54)         (52)         (52)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (58)         (57)         (55)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma, Metastatic, Kidney                                                1 (2%)                                             
   Lymph Node, Mediastinal                                         (1)                       (1)                                    
      Histiocytic Sarcoma                                           1 (100%)                                                        
   Spleen                                             (59)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                                          1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Thymus                                             (52)         (52)         (46)         (40)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Melanoma NOS                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    11 (18%)     12 (20%)      5 (8%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)       6 (10%)                                                         
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)       7 (12%)      5 (8%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (5%)      10 (17%)     17 (28%)                               
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Sarcoma, Metastatic, Kidney                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (1)                                                              
      External Ear, Fibrosarcoma                                    1 (100%)                                                        
   Eye                                                (2)          (2)                                                              
      Carcinoma, Metastatic, Harderian Gland           1 (50%)      1 (50%)                                                         
      Ciliary Body, Adenoma                                         1 (50%)                                                         
   Harderian Gland                                    (3)          (2)                       (1)                                    
      Adenoma                                          1 (33%)      1 (50%)                   1 (100%)                              
      Carcinoma                                        1 (33%)      1 (50%)                                                         
      Bilateral, Adenoma                               1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         2 (3%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05212-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 09:53:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        125 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            39          40          59          60                                       
     Total Primary Neoplasms                           59          69         125         118                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          35          46          42                                       
     Total Benign Neoplasms                            41          48          51          44                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          19          51          60                                       
     Total Malignant Neoplasms                         18          21          73          74                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4          21          22                                       
     Total Metastatic Neoplasm                          2           7          27          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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