TDMS Study 05212-03 Pathology Tables
NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 Facility: Battelle Columbus Laboratory Chemical CAS #: 604-75-1 Lock Date: 02/20/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| DAY ON TEST | 5| 3| 3| 3| 7| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6| 7| 6| 3| 3| 3| | 9| 6| 5| 6| 6| 0| 6| 5| 5| 0| 5| 5| 5| 6| 6| 6| 5| 6| 4| 0| 0| 0| 6| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X | Clear Cell Focus | | Eosinophilic Focus | X X X X X | Necrosis, Multifocal | | Vacuolization Cytoplasmic | 1 | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | 2 | Hyperplasia, Focal, Squamous | 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | 3 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + M + + + + + + + + + + + + + + M + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| DAY ON TEST | 5| 3| 3| 3| 7| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6| 7| 6| 3| 3| 3| | 9| 6| 5| 6| 6| 0| 6| 5| 5| 0| 5| 5| 5| 6| 6| 6| 5| 6| 4| 0| 0| 0| 6| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia | 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 3 3 3 3 2 2 3 3 2 2 3 4 2 4 3| Cyst | 3 | Follicle, Cyst | X X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 2 3 2 3 | Endometrium, Hyperplasia, Cystic | 3 2 3 3 3 3 3 4 3 3 3 3 1 3 3 3 2 3 3 4| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Bronchial, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Bronchial | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 3 | Hyperplasia, Focal, Reticulum Cell | | Hyperplasia, Lymphoid | 2 | Capsule, Mineralization | | Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 2 3 2 3 2 2 3 3 3 2 2 3 2 2 2| Hyperplasia, Focal, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 | __________________________________________________________________________| Skin | + + + + + + + + + M + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| DAY ON TEST | 5| 3| 3| 3| 7| 6| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 2| 6| 7| 6| 3| 3| 3| | 9| 6| 5| 6| 6| 0| 6| 5| 5| 0| 5| 5| 5| 6| 6| 6| 5| 6| 4| 0| 0| 0| 6| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Femur, Hyperostosis, Focal | 3 | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + | Sciatic, Axon, Degeneration | 2 2 | __________________________________________________________________________| Spinal Cord | + + | Degeneration | 2 | Nerve, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | Phthisis Bulbi | X | __________________________________________________________________________| Harderian Gland | + + | Cyst | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 2 2 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 6| 4| 4| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 3| 2| 6| 6| 5| 3| 5| 3| 6| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| | 5| 2| 0| 0| 2| 5| 7| 5| 0| 6| 5| 5| 6| 5| 0| 5| 8| 6| 5| 6| 6| 5| 0| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X| Clear Cell Focus | X X | Eosinophilic Focus | X X X X | Necrosis, Multifocal | 2 3 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | | Hyperplasia, Focal, Squamous | | Ulcer | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Hypertrophy | 2 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 3 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 6| 4| 4| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 3| 2| 6| 6| 5| 3| 5| 3| 6| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| | 5| 2| 0| 0| 2| 5| 7| 5| 0| 6| 5| 5| 6| 5| 0| 5| 8| 6| 5| 6| 6| 5| 0| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia | 2 1 2 2 1 2 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 2 2 3 3 2 2 2 3 2 3 4 4 2 3| Cyst | | Follicle, Cyst | X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 2 2 1 3 | Endometrium, Hyperplasia, Cystic | 3 2 3 3 3 3 2 2 3 3 3 2 3 3 3 2 2 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Bronchial, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Bronchial | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +| Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mediastinal | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 3 2 3 3 3 3 2 4 3| Hyperplasia, Focal, Reticulum Cell | 3 | Hyperplasia, Lymphoid | 3 | Capsule, Mineralization | 3 | Lymphoid Follicle, Atrophy | 3 | Red Pulp, Atrophy | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 2 1 2 2 1 1 1 3 1 2 2 2 3 2 3| Hyperplasia, Focal, Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 6| 4| 4| 6| 7| 3| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| DAY ON TEST | 3| 2| 6| 6| 5| 3| 5| 3| 6| 3| 3| 3| 3| 3| 6| 3| 9| 3| 3| 3| 1| 3| 3| 3| 3| | 5| 2| 0| 0| 2| 5| 7| 5| 0| 6| 5| 5| 6| 5| 0| 5| 8| 6| 5| 6| 6| 5| 0| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Femur, Hyperostosis, Focal | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | | Degeneration | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Phthisis Bulbi | | __________________________________________________________________________| Harderian Gland | + | Cyst | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 2 1 1 1 1 1 1 1 2 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| | | | 6| 5| 6| 0| 6| 6| 8| 5| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Basophilic Focus | | 4 | Clear Cell Focus | | 2 | Eosinophilic Focus | X | 10 | Necrosis, Multifocal | | 2 2.5| Vacuolization Cytoplasmic | | 1 1.0| __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Acinus, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Dysplasia | | 1 2.0| Hyperplasia, Focal, Squamous | | 1 3.0| Ulcer | 2 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | Aorta, Mineralization | 4 | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Mineralization | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Hyperplasia | | 1 2.0| Hypertrophy | | 2 2.5| Vacuolization Cytoplasmic | | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + M + M | 52 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| | | | 6| 5| 6| 0| 6| 6| 8| 5| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Pars Distalis, Angiectasis | | 2 2.0| Pars Distalis, Cyst | X X | 2 | Pars Distalis, Hyperplasia | 2 2 | 6 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Hyperplasia | 2 1 | 16 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Atrophy | 4 3 3 2 4 3 | 39 2.8| Cyst | X | 2 3.0| Follicle, Cyst | X X | 15 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 1 | 10 2.1| Endometrium, Hyperplasia, Cystic | 3 3 3 2 2 3 2 3 | 46 2.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | | 3 | Bronchial, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Bronchial | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 58 | Hyperplasia, Plasma Cell | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 58 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hematopoietic Cell Proliferation | 3 | 13 3.0| Hyperplasia, Focal, Reticulum Cell | | 1 3.0| Hyperplasia, Lymphoid | | 2 2.5| Capsule, Mineralization | | 1 3.0| Lymphoid Follicle, Atrophy | | 2 2.5| Red Pulp, Atrophy | | 2 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 4| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| | | | 6| 5| 6| 0| 6| 6| 8| 5| 6| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Atrophy | 3 4 2 2 2 3 2 | 41 2.3| Hyperplasia, Focal, Lymphoid | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | Hyperplasia, Cystic | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Femur, Hyperostosis, Focal | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | Sciatic, Axon, Degeneration | | 2 2.0| __________________________________________________________________________|____________| Spinal Cord | | 2 | Degeneration | | 1 2.0| Nerve, Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 2 | Phthisis Bulbi | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Cyst | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Nephropathy, Chronic | 4 | 17 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 3| 6| | 6| 6| 6| 5| 5| 0| 5| 0| 0| 5| 0| 0| 5| 6| 5| 6| 4| 5| 2| 2| 5| 6| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | | Developmental Malformation | | Eosinophilic Focus | X X X X X X X X | Bile Duct, Hyperplasia, Focal | 4 | Centrilobular, Hypertrophy | | __________________________________________________________________________| Mesentery | + | Artery, Inflammation, Chronic | | Fat, Inflammation, Chronic | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | | Ulcer | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hypertrophy | 2 | Capsule, Accessory Adrenal Cortical | | Nodule | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Hyperplasia | 2 2 2 3 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 3| 6| | 6| 6| 6| 5| 5| 0| 5| 0| 0| 5| 0| 0| 5| 6| 5| 6| 4| 5| 2| 2| 5| 6| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | 2 | Follicular Cell, Hyperplasia | 2 1 1 2 1 3 3 2 2 3 1 4 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + M + + + + +| Duct, Ectasia | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 3 3 3 4 3 3 3 2 2 4 3 3 2 | Bilateral, Follicle, Cyst | X | Follicle, Cyst | X X X X X X | Periovarian Tissue, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 3 2 3 3 2| Endometrium, Hyperplasia, Cystic | 4 4 3 4 4 3 2 2 2 3 3 2 3 2 4 3 3 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | | Myeloid Cell, Erythroid Cell, Atrophy| 3 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 2 | Hyperplasia, Lymphoid | | Lymphoid Follicle, Degeneration | 3 | Red Pulp, Atrophy | 3 | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| Atrophy | 2 2 3 2 2 2 3 2 3 3 2 2 3 4 4 2 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Multifocal | | Dermis, Sebaceous Gland, Hyperplasia | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 6| 3| 6| 6| 3| 3| 3| 3| 1| 3| 3| 9| 3| 3| 3| 3| 6| | 6| 6| 6| 5| 5| 0| 5| 0| 0| 5| 0| 0| 5| 6| 5| 6| 4| 5| 2| 2| 5| 6| 6| 5| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | __________________________________________________________________________| Peripheral Nerve | + | Sciatic, Axon, Degeneration | 2 | __________________________________________________________________________| Spinal Cord | + | Degeneration | 2 | Nerve, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Phthisis Bulbi | 4 | __________________________________________________________________________| Harderian Gland | + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 2 1 1 2 1 1 | Artery, Pelvis, Inflammation, Chronic| | Renal Tubule, Necrosis, Acute, | | Diffuse | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 4| 6| 3| 3| 3| 3| 0| 3| 6| 6| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| | 0| 6| 5| 5| 9| 0| 6| 6| 5| 6| 1| 6| 2| 0| 5| 5| 5| 6| 1| 0| 5| 6| 5| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | X X | Developmental Malformation | X | Eosinophilic Focus | X X X X X X X X X | Bile Duct, Hyperplasia, Focal | | Centrilobular, Hypertrophy | 1 | __________________________________________________________________________| Mesentery | + + | Artery, Inflammation, Chronic | 3 | Fat, Inflammation, Chronic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | 2 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hypertrophy | | Capsule, Accessory Adrenal Cortical | | Nodule | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Hyperplasia | 3 3 | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 4| 6| 3| 3| 3| 3| 0| 3| 6| 6| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| | 0| 6| 5| 5| 9| 0| 6| 6| 5| 6| 1| 6| 2| 0| 5| 5| 5| 6| 1| 0| 5| 6| 5| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | | Follicular Cell, Hyperplasia | 1 1 1 1 1 3 3 1 2 2 1 2 3 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Duct, Ectasia | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 3 4 2 4 4 4 3 3 3 3 2 3 3 3 | Bilateral, Follicle, Cyst | | Follicle, Cyst | X X X X X X| Periovarian Tissue, Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 3 2 | Endometrium, Hyperplasia, Cystic | 3 2 2 3 2 3 2 2 2 4 4 4 4 2 2 2 3 4 3 2 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Myelofibrosis | 3 | Myeloid Cell, Erythroid Cell, Atrophy| | __________________________________________________________________________| Lymph Node | + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + M + + + + + M + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Lymph Node, Mediastinal | + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | | Lymphoid Follicle, Degeneration | | Red Pulp, Atrophy | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 3 4 3 4 2 3 4 3 2 4 3 2 3 3 2 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Multifocal | 3 | Dermis, Sebaceous Gland, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 3| 4| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 4| 6| 3| 3| 3| 3| 0| 3| 6| 6| 3| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| | 0| 6| 5| 5| 9| 0| 6| 6| 5| 6| 1| 6| 2| 0| 5| 5| 5| 6| 1| 0| 5| 6| 5| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 125 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | __________________________________________________________________________| Peripheral Nerve | + + | Sciatic, Axon, Degeneration | 1 1 | __________________________________________________________________________| Spinal Cord | + + | Degeneration | | Nerve, Degeneration | 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | | Phthisis Bulbi | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 2 1 1 1 1 | Artery, Pelvis, Inflammation, Chronic| 3 | Renal Tubule, Necrosis, Acute, | | Diffuse | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| | | | 6| 5| 5| 0| 6| 6| 5| 1| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 125 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Clear Cell Focus | X | 3 | Developmental Malformation | | 1 | Eosinophilic Focus | X X | 19 | Bile Duct, Hyperplasia, Focal | | 1 4.0| Centrilobular, Hypertrophy | 2 | 2 1.5| __________________________________________________________________________|____________| Mesentery | | 3 | Artery, Inflammation, Chronic | | 1 3.0| Fat, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Acinus, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hyperplasia, Focal, Squamous | | 1 2.0| Ulcer | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | Artery, Inflammation, Chronic | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Atrium, Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Cyst | | 1 2.0| Hypertrophy | | 1 2.0| Capsule, Accessory Adrenal Cortical | | | Nodule | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| | | | 6| 5| 5| 0| 6| 6| 5| 1| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 125 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + | 56 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Pars Distalis, Angiectasis | 3 | 2 2.5| Pars Distalis, Hyperplasia | 2 3 2 | 9 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Inflammation, Chronic Active, Focal | | 1 2.0| Follicular Cell, Hyperplasia | 4 2 1 1 3 | 34 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 57 | Duct, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Atrophy | 3 3 3 3 3 3 3 | 39 3.1| Bilateral, Follicle, Cyst | | 1 | Follicle, Cyst | X X X X | 16 | Periovarian Tissue, Cyst | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 3 | 10 2.7| Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 3 2 3 4 | 50 2.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Calvarium, Myelofibrosis | | 1 3.0| Myeloid Cell, Erythroid Cell, Atrophy| | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M M + M + M | 56 | Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hematopoietic Cell Proliferation | | 4 2.5| Hyperplasia, Lymphoid | 2 | 1 2.0| Lymphoid Follicle, Degeneration | | 1 3.0| Red Pulp, Atrophy | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| | | | 6| 5| 5| 0| 6| 6| 5| 1| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 125 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + | 58 | Atrophy | 3 4 3 3 4 3 2 3 | 44 2.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Ulcer, Multifocal | | 1 3.0| Dermis, Sebaceous Gland, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Compression | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | | 3 | Sciatic, Axon, Degeneration | | 3 1.3| __________________________________________________________________________|____________| Spinal Cord | | 3 | Degeneration | | 1 2.0| Nerve, Degeneration | | 3 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | __________________________________________________________________________|____________| Eye | | 1 | Phthisis Bulbi | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Nephropathy, Chronic | 1 | 15 1.2| Artery, Pelvis, Inflammation, Chronic| | 1 3.0| Renal Tubule, Necrosis, Acute, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| | | DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| | | | 6| 5| 5| 0| 6| 6| 5| 1| 6| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 125 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Diffuse | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 6| 4| 5| 7| 3| 7| 4| 6| 6| 6| 4| 6| 7| 4| 6| 7| 7| 6| 7| DAY ON TEST | 1| 1| 1| 1| 6| 6| 3| 6| 9| 0| 9| 1| 6| 3| 1| 1| 6| 8| 0| 6| 3| 1| 1| 4| 1| | 2| 9| 9| 9| 5| 3| 0| 0| 6| 2| 6| 2| 0| 6| 5| 4| 0| 9| 6| 0| 8| 9| 9| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + + + + + + + M + M M M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | X X X X | Hemorrhage | | Infiltration Cellular, Lymphocyte | 2 | Centrilobular, Hypertrophy | 2 3 2 2 2 2 | Hepatocyte, Centrilobular, | | Hypertrophy | 3 3 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Liver | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Diffuse, Squamous | | Hyperplasia, Multifocal, Squamous | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Accessory Adrenal Cortical | | Nodule | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + M + M + + + M + + + M +| __________________________________________________________________________| Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + M +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 2 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 3 3 3 3 4 3 4 2 3 3 3 1 3 2 2 2 2 3 1 4 3 3 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 6| 4| 5| 7| 3| 7| 4| 6| 6| 6| 4| 6| 7| 4| 6| 7| 7| 6| 7| DAY ON TEST | 1| 1| 1| 1| 6| 6| 3| 6| 9| 0| 9| 1| 6| 3| 1| 1| 6| 8| 0| 6| 3| 1| 1| 4| 1| | 2| 9| 9| 9| 5| 3| 0| 0| 6| 2| 6| 2| 0| 6| 5| 4| 0| 9| 6| 0| 8| 9| 9| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + M +| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4| Mineralization | 3 | Follicle, Cyst | X X | Periovarian Tissue, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 2 2 4 | Endometrium, Hyperplasia, Cystic | 4 2 3 2 1 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + M + + + + + +| Atrophy | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + M + + + M + + + M M + + M + M +| Atrophy | | __________________________________________________________________________| Lymph Node, Mediastinal | + | Angiectasis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Hematopoietic Cell Proliferation | 2 3 2 3 | __________________________________________________________________________| Thymus | M + + + M + M + + + + + + + M M + + + + + M M M M| Atrophy | 4 4 4 4 4 4 4 4 4 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | | Degeneration | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 6| 6| 4| 5| 7| 3| 7| 4| 6| 6| 6| 4| 6| 7| 4| 6| 7| 7| 6| 7| DAY ON TEST | 1| 1| 1| 1| 6| 6| 3| 6| 9| 0| 9| 1| 6| 3| 1| 1| 6| 8| 0| 6| 3| 1| 1| 4| 1| | 2| 9| 9| 9| 5| 3| 0| 0| 6| 2| 6| 2| 0| 6| 5| 4| 0| 9| 6| 0| 8| 9| 9| 4| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Infiltration Cellular, Lymphocyte | 2 | Alveolar Epithelium, Hyperplasia | 3 | Arteriole, Infiltration Cellular, | | Lymphocyte | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 1 2 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 7| 7| 7| 6| 5| 6| 7| 6| 6| 4| 6| 3| 6| 6| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 1| 6| 6| 6| 0| 1| 1| 9| 7| 6| 1| 4| 9| 6| 3| 9| 9| 6| 1| 3| 1| 7| 1| 6| 1| | 9| 0| 0| 6| 1| 2| 9| 2| 5| 7| 1| 2| 1| 0| 5| 3| 9| 4| 9| 5| 1| 0| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + M + + + + M M + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 4 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | X X X X | Hemorrhage | 4 | Infiltration Cellular, Lymphocyte | | Centrilobular, Hypertrophy | 3 3 3 | Hepatocyte, Centrilobular, | | Hypertrophy | 3 3 3 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectopic Liver | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Diffuse, Squamous | 2 | Hyperplasia, Multifocal, Squamous | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Accessory Adrenal Cortical | | Nodule | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + M + + M + + + + M + + + M +| __________________________________________________________________________| Pituitary Gland | + + + M + + + I M + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 3 3 1 3 3 3 4 3 3 3 3 3 3 2 4 1 3 3 4 4 3 1 4 1 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 7| 7| 7| 6| 5| 6| 7| 6| 6| 4| 6| 3| 6| 6| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 1| 6| 6| 6| 0| 1| 1| 9| 7| 6| 1| 4| 9| 6| 3| 9| 9| 6| 1| 3| 1| 7| 1| 6| 1| | 9| 0| 0| 6| 1| 2| 9| 2| 5| 7| 1| 2| 1| 0| 5| 3| 9| 4| 9| 5| 1| 0| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + I + + +| __________________________________________________________________________| Ovary | + + + + + + + + + + M + + + + + + + + + + + + + +| Atrophy | 4 3 4 4 4 4 4 3 4 4 4 4 4 4 4 4 2 4 3| Mineralization | | Follicle, Cyst | | Periovarian Tissue, Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 2 2 3 | Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M M + M + + + + + + + + + M + + + +| Atrophy | 2 | __________________________________________________________________________| Lymph Node, Mediastinal | + | Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Hematopoietic Cell Proliferation | 3 2 2 2 2 2 3 2 | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + M + + + M M + + + + +| Atrophy | 2 3 3 4 4 3 4 3 4 3 4 4 3 4 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | + | Degeneration | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 4| 4| 6| 7| 7| 7| 6| 5| 6| 7| 6| 6| 4| 6| 3| 6| 6| 7| 7| 7| 4| 7| 4| 7| DAY ON TEST | 1| 6| 6| 6| 0| 1| 1| 9| 7| 6| 1| 4| 9| 6| 3| 9| 9| 6| 1| 3| 1| 7| 1| 6| 1| | 9| 0| 0| 6| 1| 2| 9| 2| 5| 7| 1| 2| 1| 0| 5| 3| 9| 4| 9| 5| 1| 0| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Infiltration Cellular, Lymphocyte | | Alveolar Epithelium, Hyperplasia | | Arteriole, Infiltration Cellular, | | Lymphocyte | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 6| 7| 6| 6| 4| 7| 7| | | DAY ON TEST | 4| 6| 2| 4| 3| 3| 7| 6| 0| 0| | | | 5| 0| 2| 8| 5| 4| 7| 0| 0| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 51 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Eosinophilic Focus | X X | 10 | Hemorrhage | | 1 4.0| Infiltration Cellular, Lymphocyte | | 1 2.0| Centrilobular, Hypertrophy | 3 2 | 11 2.5| Hepatocyte, Centrilobular, | | | Hypertrophy | 2 2 | 10 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Ectopic Liver | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hyperplasia, Diffuse, Squamous | | 1 2.0| Hyperplasia, Multifocal, Squamous | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Capsule, Accessory Adrenal Cortical | | | Nodule | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + | 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + + M | 53 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia | 2 2 | 6 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 6| 7| 6| 6| 4| 7| 7| | | DAY ON TEST | 4| 6| 2| 4| 3| 3| 7| 6| 0| 0| | | | 5| 0| 2| 8| 5| 4| 7| 0| 0| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Hyperplasia | 2 2 3 3 3 3 4 2 3 4 | 59 2.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Ovary | + + + + + + M + + + | 58 | Atrophy | 4 4 4 4 4 4 | 44 3.8| Mineralization | | 1 3.0| Follicle, Cyst | X X | 4 | Periovarian Tissue, Cyst | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 3 2 | 10 2.6| Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 | 19 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Myelofibrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 58 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M | 48 | Atrophy | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mediastinal | + | 3 | Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Developmental Malformation | X | 1 | Hematopoietic Cell Proliferation | 2 | 13 2.3| __________________________________________________________________________|____________| Thymus | + + M + + M + + + M | 44 | Atrophy | 4 4 4 4 3 | 30 3.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + M | 57 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 6| 4| 6| 6| 7| 6| 6| 4| 7| 7| | | DAY ON TEST | 4| 6| 2| 4| 3| 3| 7| 6| 0| 0| | | | 5| 0| 2| 8| 5| 4| 7| 0| 0| 6| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Peripheral Nerve | + + | 2 | Sciatic, Axon, Degeneration | 2 | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | + | 2 | Degeneration | 2 | 1 2.0| Nerve, Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Foreign Body | X | 1 | Infiltration Cellular, Lymphocyte | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 1 3.0| Arteriole, Infiltration Cellular, | | | Lymphocyte | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Nephropathy, Chronic | 2 | 10 1.4| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 5| 6| 4| 5| 5| 4| 4| 4| 6| 5| 4| 4| 6| 5| 5| 4| 6| 4| 5| 5| 5| 6| 5| 4| 4| DAY ON TEST | 2| 1| 1| 6| 7| 6| 6| 6| 1| 9| 6| 5| 1| 6| 9| 6| 1| 7| 9| 6| 6| 1| 3| 5| 6| | 6| 7| 5| 6| 7| 0| 0| 0| 4| 5| 0| 0| 7| 9| 6| 0| 4| 0| 6| 8| 7| 3| 5| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + M + + + M + M + + M + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Eosinophilic Focus | X X X X | Hematopoietic Cell Proliferation, | | Focal | 2 | Hemorrhage | | Infarct | 4 | Mixed Cell Focus | | Necrosis, Multifocal | | Thrombosis | X | Centrilobular, Hypertrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | Hepatocyte, Centrilobular, | | Hypertrophy | 3 3 3 3 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Focal | 4 | Inflammation, Granulomatous | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Multifocal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 5| 6| 4| 5| 5| 4| 4| 4| 6| 5| 4| 4| 6| 5| 5| 4| 6| 4| 5| 5| 5| 6| 5| 4| 4| DAY ON TEST | 2| 1| 1| 6| 7| 6| 6| 6| 1| 9| 6| 5| 1| 6| 9| 6| 1| 7| 9| 6| 6| 1| 3| 5| 6| | 6| 7| 5| 6| 7| 0| 0| 0| 4| 5| 0| 0| 7| 9| 6| 0| 4| 0| 6| 8| 7| 3| 5| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Infiltration Cellular, Lymphocyte | | Follicular Cell, Hyperplasia | 3 4 2 3 3 2 3 2 3 3 2 3 4 3 3 3 4 3 3 3 3 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Duct, Ectasia | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 4 4 3 4 4 4 4 4 2 3 4 3 4 | Follicle, Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 3 3 3| Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | M M + M + + + + + + + + + + + + + + + + + M + + +| Hemorrhage | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 | __________________________________________________________________________| Thymus | M M + M + + M + M + + + M + + + + + + M M M + + +| Atrophy | 4 4 4 3 4 3 4 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 5| 6| 4| 5| 5| 4| 4| 4| 6| 5| 4| 4| 6| 5| 5| 4| 6| 4| 5| 5| 5| 6| 5| 4| 4| DAY ON TEST | 2| 1| 1| 6| 7| 6| 6| 6| 1| 9| 6| 5| 1| 6| 9| 6| 1| 7| 9| 6| 6| 1| 3| 5| 6| | 6| 7| 5| 6| 7| 0| 0| 0| 4| 5| 0| 0| 7| 9| 6| 0| 4| 0| 6| 8| 7| 3| 5| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | | Nephropathy, Chronic | 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Ulcer | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 4| 4| 5| 4| 6| 4| 0| 5| 5| 5| 4| 6| 5| 0| 5| 5| 5| 4| 5| 4| 5| 4| 5| 0| DAY ON TEST | 1| 0| 6| 5| 7| 1| 7| 0| 3| 9| 4| 1| 0| 7| 0| 4| 6| 8| 5| 8| 6| 6| 9| 8| 0| | 2| 3| 0| 4| 9| 7| 1| 7| 3| 4| 1| 2| 0| 0| 7| 7| 3| 3| 4| 9| 0| 2| 1| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + M M + + + + M M + + M M + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Eosinophilic Focus | X X X X X X X | Hematopoietic Cell Proliferation, | | Focal | | Hemorrhage | 3 | Infarct | | Mixed Cell Focus | X | Necrosis, Multifocal | | Thrombosis | | Centrilobular, Hypertrophy | 3 3 3 3 3 3 2 3 3 3 | Hepatocyte, Centrilobular, | | Hypertrophy | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct, Focal | | Inflammation, Granulomatous | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Multifocal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | Hypertrophy | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + M + M + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 4| 4| 5| 4| 6| 4| 0| 5| 5| 5| 4| 6| 5| 0| 5| 5| 5| 4| 5| 4| 5| 4| 5| 0| DAY ON TEST | 1| 0| 6| 5| 7| 1| 7| 0| 3| 9| 4| 1| 0| 7| 0| 4| 6| 8| 5| 8| 6| 6| 9| 8| 0| | 2| 3| 0| 4| 9| 7| 1| 7| 3| 4| 1| 2| 0| 0| 7| 7| 3| 3| 4| 9| 0| 2| 1| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Infiltration Cellular, Lymphocyte | 2 | Follicular Cell, Hyperplasia | 4 2 3 3 3 3 4 3 4 2 4 3 3 3 3 2 4 3 3 3 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + M + + + + M + + + + + + + + + + + + +| Duct, Ectasia | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 2 4 2 3 3 2 4 4 4 4 3 3 3 2 4 | Follicle, Cyst | X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + M + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 3 2 | Endometrium, Hyperplasia, Cystic | 2 3 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + M + + + M + + + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + M + M + M + M + M + + + + + + + M + + +| Hemorrhage | | __________________________________________________________________________| Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + M M + + M M + + + + + + + + + + +| Atrophy | 4 4 4 4 3 4 4 4 3 4 2 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + M + + + + + + M + + + + + + + + + M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 6| 4| 4| 5| 4| 6| 4| 0| 5| 5| 5| 4| 6| 5| 0| 5| 5| 5| 4| 5| 4| 5| 4| 5| 0| DAY ON TEST | 1| 0| 6| 5| 7| 1| 7| 0| 3| 9| 4| 1| 0| 7| 0| 4| 6| 8| 5| 8| 6| 6| 9| 8| 0| | 2| 3| 0| 4| 9| 7| 1| 7| 3| 4| 1| 2| 0| 0| 7| 7| 3| 3| 4| 9| 0| 2| 1| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar Epithelium, Hyperplasia, | | Focal | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | 2 | Nephropathy, Chronic | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | Ulcer | 3 | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 5| 4| 4| 5| 4| 4| 5| | | DAY ON TEST | 7| 6| 1| 6| 9| 1| 0| 9| 6| 7| | | | 8| 0| 0| 9| 9| 4| 4| 4| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Congestion | | 1 3.0| Eosinophilic Focus | X | 12 | Hematopoietic Cell Proliferation, | | | Focal | | 1 2.0| Hemorrhage | | 1 3.0| Infarct | | 1 4.0| Mixed Cell Focus | | 1 | Necrosis, Multifocal | 3 | 1 3.0| Thrombosis | X | 2 | Centrilobular, Hypertrophy | 3 3 3 2 3 | 29 2.9| Hepatocyte, Centrilobular, | | | Hypertrophy | 3 3 | 10 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Infarct, Focal | | 1 4.0| Inflammation, Granulomatous | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Congestion, Multifocal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Hyperplasia | | 1 2.0| Hypertrophy | | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 5| 4| 4| 5| 4| 4| 5| | | DAY ON TEST | 7| 6| 1| 6| 9| 1| 0| 9| 6| 7| | | | 8| 0| 0| 9| 9| 4| 4| 4| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + M + + M + + | 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Pars Distalis, Hyperplasia | 2 | 3 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Infiltration Cellular, Lymphocyte | | 1 2.0| Follicular Cell, Hyperplasia | 1 2 1 3 3 2 3 4 1 3 | 54 2.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + | 56 | Duct, Ectasia | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 60 | Atrophy | 2 4 3 2 4 4 | 38 3.3| Follicle, Cyst | | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 59 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 3 | 8 2.8| Endometrium, Hyperplasia, Cystic | 3 | 14 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M | 54 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + M + + + + + | 47 | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | Hematopoietic Cell Proliferation | | 4 2.0| __________________________________________________________________________|____________| Thymus | M + + M + + M + + M | 43 | Atrophy | 4 4 | 22 3.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + M | 53 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 5| 4| 4| 5| 4| 4| 5| | | DAY ON TEST | 7| 6| 1| 6| 9| 1| 0| 9| 6| 7| | | | 8| 0| 0| 9| 9| 4| 4| 4| 0| 0| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | Sciatic, Axon, Degeneration | 1 | 1 1.0| __________________________________________________________________________|____________| Spinal Cord | + | 1 | Nerve, Degeneration | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar Epithelium, Hyperplasia, | | | Focal | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Inflammation, Subacute | | 1 2.0| Nephropathy, Chronic | 2 | 5 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Inflammation, Chronic | | 1 3.0| Ulcer | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 5| 1| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 6| 3| 2| 2| 6| 3| 6| 3| 3| 6| 2| 8| 1| 3| 3| 3| 6| | 9| 9| 4| 0| 9| 9| 0| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 0| 9| 6| 7| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + A + + + +| Basophilic Focus | X X | Clear Cell Focus | X X X X X | Clear Cell Focus, Multifocal | X | Eosinophilic Focus | X X X X X X X X X | Mixed Cell Focus | X | Necrosis | | Necrosis, Multifocal | | Vacuolization Cytoplasmic | 1 2 1 1| __________________________________________________________________________| Mesentery | + | Fat, Inflammation, Chronic | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | Gingiva, Hyperplasia, Focal, Squamous| | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| Hypertrophy | 2 2 3 2 2 2 | Capsule, Hyperplasia | 2 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| Hyperplasia, Focal | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Cyst | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 5| 1| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 6| 3| 2| 2| 6| 3| 6| 3| 3| 6| 2| 8| 1| 3| 3| 3| 6| | 9| 9| 4| 0| 9| 9| 0| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 0| 9| 6| 7| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Infiltration Cellular, Lymphocyte | 1 1 | Spermatocele | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Infiltration Cellular, Lymphocyte | 3 | Inflammation, Chronic | 1 | Duct, Ectasia | 2 3 3 3 2 3 3 3 3 3 3 2 2 2 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Inguinal, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + M + M + + + + + + + M M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| Hematopoietic Cell Proliferation | 3 3 | Hyperplasia, Lymphoid | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + M + + + + + + + + + + +| Atrophy | 2 2 3 2 2 3 2 3 2 2 2 2 4 1 3 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 4| 7| 7| 4| 7| 5| 1| 7| 7| 7| 4| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 6| 3| 2| 2| 6| 3| 6| 3| 3| 6| 2| 8| 1| 3| 3| 3| 6| | 9| 9| 4| 0| 9| 9| 0| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 0| 9| 6| 7| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Bilateral, Inflammation, Chronic | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Nephropathy, Chronic | 2 1 4 2 2 2 2 2 2 2 1 2 3 1 1 1 1 1 1 2 1 2| Cortex, Cyst | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 2| 6| 2| 6| 2| 3| 2| 2| 6| 3| 6| 3| 3| 3| 3| 3| 6| 2| 3| 3| 0| 2| 3| | 9| 0| 9| 0| 9| 0| 9| 0| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X 1 X | Clear Cell Focus, Multifocal | | Eosinophilic Focus | X X X X X | Mixed Cell Focus | | Necrosis | 1 3 | Necrosis, Multifocal | | Vacuolization Cytoplasmic | 1 1 1 2 | __________________________________________________________________________| Mesentery | | Fat, Inflammation, Chronic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | Gingiva, Hyperplasia, Focal, Squamous| 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis, Focal | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 1 2 3 3 2 3 | Capsule, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Pars Distalis, Cyst | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 2| 6| 2| 6| 2| 3| 2| 2| 6| 3| 6| 3| 3| 3| 3| 3| 6| 2| 3| 3| 0| 2| 3| | 9| 0| 9| 0| 9| 0| 9| 0| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Hyperplasia | 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 4 | Infiltration Cellular, Lymphocyte | | Spermatocele | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 | Infiltration Cellular, Lymphocyte | | Inflammation, Chronic | 2 1 4 2 | Duct, Ectasia | 2 2 2 2 3 3 3 2 2 3 2 3 2 3 3 3 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Inguinal, Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + + M + + + M + M + + + M + + + + + + + + + M +| Atrophy | 2 2 2 3 2 1 2 2 2 3 2 3 2 4 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 3| 2| 6| 2| 6| 2| 3| 2| 2| 6| 3| 6| 3| 3| 3| 3| 3| 6| 2| 3| 3| 0| 2| 3| | 9| 0| 9| 0| 9| 0| 9| 0| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 7| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia, | | Focal | | Alveolar Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Bilateral, Inflammation, Chronic | 3 | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Nephropathy, Chronic | 1 1 1 1 1 2 2 1 1 3 1 2 1 1 2 2 2 2 2 1 2 2 2 1| Cortex, Cyst | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| | | | 0| 9| 7| 0| 9| 0| 0| 9| 0| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | Peyer's Patch, Hyperplasia, Lymphoid | 2 | 2 2.5| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Basophilic Focus | | 2 | Clear Cell Focus | X | 9 1.0| Clear Cell Focus, Multifocal | X X X | 4 | Eosinophilic Focus | X X X X | 18 | Mixed Cell Focus | X | 2 | Necrosis | | 2 2.0| Necrosis, Multifocal | 3 | 1 3.0| Vacuolization Cytoplasmic | 2 | 9 1.3| __________________________________________________________________________|____________| Mesentery | + | 2 | Fat, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hyperplasia, Focal, Squamous | 2 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | | 1 | Gingiva, Hyperplasia, Focal, Squamous| | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Angiectasis, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 59 | Hypertrophy | 2 | 13 2.2| Capsule, Hyperplasia | | 3 2.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| | | | 0| 9| 7| 0| 9| 0| 0| 9| 0| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 58 | Pars Distalis, Cyst | | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | Follicular Cell, Hyperplasia | 1 | 4 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Granuloma Sperm | | 1 4.0| Infiltration Cellular, Lymphocyte | | 2 1.0| Spermatocele | X | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Ectasia | | 2 3.0| Infiltration Cellular, Lymphocyte | | 1 3.0| Inflammation, Chronic | 3 3 | 7 2.3| Duct, Ectasia | 3 3 2 3 2 3 2 2 | 40 2.6| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node | + | 2 | Inguinal, Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 54 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | Hematopoietic Cell Proliferation | 3 | 3 3.0| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + M + + + + | 52 | Atrophy | 3 3 3 2 2 2 2 2 | 39 2.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| | | | 0| 9| 7| 0| 9| 0| 0| 9| 0| 9| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar Epithelium, Hyperplasia, | | | Focal | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 4 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Bilateral, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Hydronephrosis | | 1 3.0| Nephropathy, Chronic | 1 2 1 2 1 2 1 | 53 1.6| Cortex, Cyst | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| DAY ON TEST | 3| 2| 3| 0| 3| 3| 3| 6| 2| 6| 3| 6| 1| 2| 2| 2| 2| 3| 6| 5| 3| 2| 2| 2| 3| | 0| 9| 0| 1| 0| 0| 0| 0| 9| 0| 0| 0| 5| 9| 9| 9| 9| 0| 0| 3| 0| 7| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X | Clear Cell Focus | X X | Clear Cell Focus, Multifocal | X | Eosinophilic Focus | X X X X X X | Mixed Cell Focus | | Vacuolization Cytoplasmic | 2 1 2 1 | Centrilobular, Hypertrophy | 2 2 | Hepatocyte, Centrilobular, | | Hypertrophy | 1 1 1 1 | __________________________________________________________________________| Mesentery | + + | Fat, Inflammation, Chronic | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 2 2 1 1 | Capsule, Hyperplasia | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| DAY ON TEST | 3| 2| 3| 0| 3| 3| 3| 6| 2| 6| 3| 6| 1| 2| 2| 2| 2| 3| 6| 5| 3| 2| 2| 2| 3| | 0| 9| 0| 1| 0| 0| 0| 0| 9| 0| 0| 0| 5| 9| 9| 9| 9| 0| 0| 3| 0| 7| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 1 1 1 1 3 1| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 4 2 | Duct, Ectasia | 3 3 2 3 3 3 3 3 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + M + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mediastinal | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + M + + + + + + M + + + + + + + + + + + + +| Atrophy | 3 2 3 3 2 2 1 2 2 2 3 1 2 3 3 2 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cartilage, Vertebra, Fracture | X | Joint, Cartilage, Fracture | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | | Sciatic, Axon, Degeneration | | __________________________________________________________________________| Spinal Cord | | Nerve, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Multifocal, | | Histiocyte | | Alveolar Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| DAY ON TEST | 3| 2| 3| 0| 3| 3| 3| 6| 2| 6| 3| 6| 1| 2| 2| 2| 2| 3| 6| 5| 3| 2| 2| 2| 3| | 0| 9| 0| 1| 0| 0| 0| 0| 9| 0| 0| 0| 5| 9| 9| 9| 9| 0| 0| 3| 0| 7| 9| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 1 2 2 1 2 1 1 1 3 2 1 2 2 2 1 2 1 | Cortex, Cyst | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 5| DAY ON TEST | 6| 6| 3| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 6| 3| 2| 6| 0| | 0| 0| 0| 9| 9| 9| 0| 0| 9| 9| 9| 9| 5| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 0| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 125 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | X X X | Clear Cell Focus, Multifocal | | Eosinophilic Focus | X X X X X X | Mixed Cell Focus | X | Vacuolization Cytoplasmic | 1 2 2 | Centrilobular, Hypertrophy | | Hepatocyte, Centrilobular, | | Hypertrophy | 2 1 1 1 | __________________________________________________________________________| Mesentery | | Fat, Inflammation, Chronic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal, Squamous | 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 2 | Capsule, Hyperplasia | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + M + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Hyperplasia | 1 1 2 1 2 1 2 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05212-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OXAZEPAM Date: 08/07/96 Route: DOSED FEED Time: 13:51:15 _____________________________________________________________________________________________________________________ | 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 5| DAY ON TEST | 6| 6| 3| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 6| 3| 2| 6| 0| | 0| 0| 0| 9| 9| 9| 0| 0| 9| 9| 9| 9| 5| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 0| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 125 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 2 1 1 1 2 1 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 4 | Duct, Ectasia | 3 3 3 2 3 3 2 2 2 3 2 3 2 2 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | |