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TDMS Study 05212-05 Pathology Tables

NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96
Route: DOSED FEED                                                                                                 Time: 07:56:27

                                                   CONTROL VS 10,000 PPM STOP




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  05/12/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 011    10,000  PPM STOP
                               Include 012    10,000  PPM STOP































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      6            6                                                               
    Moribund Sacrifice                                11           19                                                               
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           25                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)                                                                          
      Polyp Adenomatous                                1 (2%)                                                                       
   Liver                                              (50)         (49)                                                             
      Histiocytic Sarcoma, Metastatic, Skin                         1 (2%)                                                          
   Mesentery                                          (10)         (13)                                                             
   Salivary Glands                                    (50)         (1)                                                              
      Myoepithelioma                                                1 (100%)                                                        
   Stomach, Forestomach                               (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (2)                                                              
      Adenoma                                                       1 (50%)                                                         
   Adrenal Medulla                                    (50)                                                                          
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (50)                                                                          
      Adenoma                                          1 (2%)                                                                       
   Pituitary Gland                                    (50)         (35)                                                             
      Pars Distalis, Adenoma                          30 (60%)     23 (66%)                                                         
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)                                                             
      Bilateral, C-Cell, Adenoma                                    2 (4%)                                                          
      C-Cell, Adenoma                                  6 (12%)      2 (4%)                                                          
      C-Cell, Carcinoma                                1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (11)                                                             
      Adenoma                                          6 (12%)      7 (64%)                                                         
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (4)                                                              
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
   Uterus                                             (50)         (5)                                                              
      Polyp Stromal                                    2 (4%)                                                                       
      Sarcoma Stromal                                  1 (2%)       1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (4)          (4)                                                              
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (25%)                                                                      
      Renal, Pheochromocytoma Malignant,                                                                                            
          Metastatic, Adrenal Medulla                  1 (25%)                                                                      
   Lymph Node, Mandibular                             (50)         (3)                                                              
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (33%)                                                         
   Lymph Node, Mesenteric                             (50)         (2)                                                              
   Spleen                                             (50)         (12)                                                             
   Thymus                                             (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (23)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)                                                                       
      Carcinoma, Multiple                                           1 (4%)                                                          
      Fibroadenoma                                    11 (22%)     17 (74%)                                                         
      Fibroadenoma, Multiple                          14 (29%)      6 (26%)                                                         
   Skin                                               (50)         (6)                                                              
      Fibroma                                                       2 (33%)                                                         
      Squamous Cell Carcinoma                                       1 (17%)                                                         
                                                             Page   3                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Histiocytic Sarcoma                      1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (1)                                                              
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                                                                          
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            14 (28%)     15 (30%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          43                                                               
     Total Primary Neoplasms                          101          80                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          38                                                               
     Total Benign Neoplasms                            77          61                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          17                                                               
     Total Malignant Neoplasms                         24          19                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                                                               
     Total Metastatic Neoplasm                          2           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           39                                                               
    Natural Death                                      8           11                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                17                                                                            
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (49)                                                                          
      Carcinoma                                        2 (4%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
   Mesentery                                          (7)          (5)                                                              
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                     1 (14%)                                                                      
   Pancreas                                           (50)                                                                          
      Acinus, Adenoma                                  1 (2%)                                                                       
      Acinus, Adenoma, Mixed Cell                      1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)                                                             
   Stomach, Glandular                                 (50)         (47)                                                             
   Tooth                                              (1)                                                                           
      Odontoma                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (50)         (1)                                                              
      Pheochromocytoma Malignant                                    1 (100%)                                                        
      Pheochromocytoma Benign                          9 (18%)                                                                      
      Bilateral, Pheochromocytoma Benign               5 (10%)                                                                      
   Islets, Pancreatic                                 (50)                                                                          
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)                                                                       
   Pituitary Gland                                    (49)         (5)                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          17 (35%)      5 (100%)                                                        
   Thyroid Gland                                      (50)         (50)                                                             
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  9 (18%)      1 (2%)                                                          
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)                                                          
      Follicular Cell, Carcinoma                       3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (1)                                                              
   Preputial Gland                                    (48)         (14)                                                             
      Adenoma                                          6 (13%)      7 (50%)                                                         
      Carcinoma                                        1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)       3 (21%)                                                         
   Testes                                             (50)         (48)                                                             
      Bilateral, Interstitial Cell, Adenoma           35 (70%)     44 (92%)                                                         
      Interstitial Cell, Adenoma                      10 (20%)      4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (9)                                                              
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (11%)                                                         
   Lymph Node, Mandibular                             (50)         (4)                                                              
   Lymph Node, Mesenteric                             (49)         (4)                                                              
   Spleen                                             (50)         (33)                                                             
      Fibroma                                          1 (2%)                                                                       
   Thymus                                             (49)                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (2)                                                              
      Adenoma                                                       1 (50%)                                                         
      Carcinoma                                                     1 (50%)                                                         
      Fibroadenoma                                     4 (8%)                                                                       
   Skin                                               (50)         (8)                                                              
      Fibroma                                          3 (6%)       2 (25%)                                                         
      Fibrosarcoma                                     2 (4%)       1 (13%)                                                         
                                                             Page   7                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  3 (6%)       2 (25%)                                                         
      Sarcoma                                          1 (2%)                                                                       
      Schwannoma Malignant                             3 (6%)                                                                       
      Squamous Cell Papilloma                          2 (4%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)       2 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (3)                                                              
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Skin           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (42)                                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            27 (54%)     34 (68%)                                                         
      Lymphoma Malignant                                            1 (2%)                                                          
      Mesothelioma Malignant                           2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 10/25/96    
Route: DOSED FEED                                                                                                 Time: 07:56:27    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        10,000                                                              
                                                                PPM STOP                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          48                                                               
     Total Primary Neoplasms                          160         116                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          48                                                               
     Total Benign Neoplasms                           115          74                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          35                                                               
     Total Malignant Neoplasms                         45          42                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1                                                               
     Total Metastatic Neoplasm                          3           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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                             ----------              END OF REPORT             ----------                                           
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