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https://ntp.niehs.nih.gov/go/4677

TDMS Study 05212-04 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              OXAZEPAM


NTP Experiment-Test: 05212-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 11:54:31




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           13           11                                                  
    Natural Death                                      4           18           31                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           27           17                                                  
    Natural Death                                                   1                                                               
  Missing                                                           1            1                                                  
  Animals Examined Microscopically                    60           59           59                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (58)         (55)                                                
      Amyloid Deposition                               6 (10%)     24 (41%)     30 (55%)                                            
      Hemorrhage                                                    1 (2%)                                                          
   Intestine Large, Rectum                            (59)         (56)         (56)                                                
      Amyloid Deposition                               1 (2%)       4 (7%)      12 (21%)                                            
   Intestine Large, Cecum                             (58)         (56)         (51)                                                
      Amyloid Deposition                               6 (10%)     23 (41%)     34 (67%)                                            
      Hemorrhage                                                    1 (2%)                                                          
      Ulcer                                                         2 (4%)                                                          
   Intestine Small, Duodenum                          (59)         (56)         (56)                                                
      Amyloid Deposition                              45 (76%)     40 (71%)     47 (84%)                                            
      Ulcer                                            1 (2%)       2 (4%)                                                          
   Intestine Small, Jejunum                           (59)         (59)         (56)                                                
      Amyloid Deposition                              28 (47%)     42 (71%)     49 (88%)                                            
      Ulcer                                            3 (5%)       2 (3%)                                                          
   Intestine Small, Ileum                             (58)         (56)         (54)                                                
      Amyloid Deposition                              52 (90%)     43 (77%)     46 (85%)                                            
   Liver                                              (60)         (59)         (59)                                                
      Amyloid Deposition                              28 (47%)     31 (53%)     35 (59%)                                            
      Eosinophilic Focus                                           20 (34%)     14 (24%)                                            
      Hematopoietic Cell Proliferation                 5 (8%)       4 (7%)       2 (3%)                                             
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Inflammation, Subacute                           4 (7%)       4 (7%)                                                          
      Necrosis                                        10 (17%)      8 (14%)      7 (12%)                                            
      Centrilobular, Hypertrophy                       3 (5%)      51 (86%)     53 (90%)                                            
   Mesentery                                          (3)          (1)          (3)                                                 
      Inflammation, Granulomatous                      1 (33%)      1 (100%)     1 (33%)                                            
      Inflammation, Subacute                           1 (33%)                                                                      
      Inflammation, Suppurative                        1 (33%)                   1 (33%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                                              1 (33%)                                            
   Pancreas                                           (60)         (59)         (59)                                                
      Amyloid Deposition                               1 (2%)       3 (5%)       1 (2%)                                             
      Ectopic Tissue                                                1 (2%)                                                          
   Salivary Glands                                    (60)         (59)         (59)                                                
      Amyloid Deposition                              35 (58%)     36 (61%)     40 (68%)                                            
   Stomach, Forestomach                               (59)         (59)         (57)                                                
      Amyloid Deposition                                            1 (2%)       3 (5%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)       5 (9%)                                             
   Stomach, Glandular                                 (59)         (59)         (57)                                                
      Amyloid Deposition                               2 (3%)      17 (29%)     19 (33%)                                            
      Mineralization                                                2 (3%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (59)         (58)                                                
      Mineralization                                                1 (2%)                                                          
   Heart                                              (60)         (59)         (59)                                                
      Amyloid Deposition                              50 (83%)     44 (75%)     53 (90%)                                            
      Degeneration                                     1 (2%)                                                                       
      Atrium, Thrombosis                               2 (3%)      23 (39%)     31 (53%)                                            
      Coronary Artery, Inflammation, Chronic                        1 (2%)                                                          
      Valve, Inflammation, Chronic                                  1 (2%)                                                          
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)                                                
      Amyloid Deposition                              24 (40%)     32 (54%)     41 (69%)                                            
      Hematopoietic Cell Proliferation                 2 (3%)       2 (3%)       3 (5%)                                             
      Infiltration Cellular, Mononuclear Cell                       1 (2%)                                                          
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Adrenal Medulla                                    (59)         (58)         (57)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (55)         (50)         (45)                                                
      Amyloid Deposition                              24 (44%)     32 (64%)     33 (73%)                                            
   Thyroid Gland                                      (60)         (59)         (59)                                                
      Amyloid Deposition                              22 (37%)     38 (64%)     46 (78%)                                            
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (58)         (57)                                                
      Inflammation, Suppurative                        1 (2%)                    2 (4%)                                             
   Ovary                                              (59)         (58)         (55)                                                
      Amyloid Deposition                              24 (41%)     13 (22%)     15 (27%)                                            
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Cyst                                             7 (12%)      5 (9%)       1 (2%)                                             
      Arteriole, Inflammation, Chronic                 3 (5%)       4 (7%)       4 (7%)                                             
   Uterus                                             (60)         (59)         (57)                                                
      Amyloid Deposition                              26 (43%)     28 (47%)     40 (70%)                                            
      Dilatation                                                                 1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                13 (22%)      2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (8)          (10)         (7)                                                 
      Axillary, Hematopoietic Cell Proliferation                    1 (10%)                                                         
      Inguinal, Hyperplasia, Lymphoid                  1 (13%)                   1 (14%)                                            
      Mediastinal, Hematopoietic Cell Proliferation                 1 (10%)                                                         
      Renal, Hematopoietic Cell Proliferation                       1 (10%)                                                         
   Lymph Node, Mandibular                             (58)         (57)         (58)                                                
      Amyloid Deposition                               3 (5%)      23 (40%)     35 (60%)                                            
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
   Lymph Node, Mesenteric                             (60)         (57)         (56)                                                
      Amyloid Deposition                              16 (27%)     30 (53%)     35 (63%)                                            
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Lymphoid                            5 (8%)       6 (11%)                                                         
      Inflammation, Suppurative                        1 (2%)                                                                       
   Spleen                                             (60)         (59)         (59)                                                
      Amyloid Deposition                              12 (20%)     20 (34%)     39 (66%)                                            
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 5 (8%)       4 (7%)       2 (3%)                                             
      Hyperplasia, Lymphoid                           14 (23%)      5 (8%)       1 (2%)                                             
   Thymus                                             (56)         (57)         (55)                                                
      Amyloid Deposition                                            1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (59)         (59)                                                
      Hyperkeratosis                                   1 (2%)       1 (2%)       1 (2%)                                             
      Ulcer                                            2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (59)         (59)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (4)          (5)          (5)                                                 
      Axon, Degeneration                               2 (50%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (59)                                                
      Fibrosis                                         1 (2%)      14 (24%)      8 (14%)                                            
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            3 (5%)       2 (3%)       6 (10%)                                            
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Subacute                           4 (7%)       4 (7%)       3 (5%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 6 (10%)      3 (5%)       2 (3%)                                             
      Alveolus, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         2 (3%)      16 (27%)     26 (44%)                                            
   Nose                                               (60)         (59)         (59)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (59)                                                
      Cyst                                                          1 (2%)                                                          
      Infarct                                                       1 (2%)                                                          
      Necrosis                                                                   1 (2%)                                             
      Glomerulus, Amyloid Deposition                  48 (80%)     39 (66%)     39 (66%)                                            
      Interstitium, Amyloid Deposition                 5 (8%)       5 (8%)       7 (12%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           24                                                  
    Natural Death                                      5           28           26                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           19           10                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)         (60)         (59)                                                
      Amyloid Deposition                               3 (5%)      29 (48%)     29 (49%)                                            
      Lumen, Hemorrhage                                                          1 (2%)                                             
   Intestine Large, Rectum                            (59)         (58)         (59)                                                
      Amyloid Deposition                                            5 (9%)       9 (15%)                                            
   Intestine Large, Cecum                             (59)         (59)         (55)                                                
      Amyloid Deposition                               6 (10%)     24 (41%)     29 (53%)                                            
      Ulcer                                                         1 (2%)       1 (2%)                                             
      Lumen, Hemorrhage                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (60)         (57)         (58)                                                
      Amyloid Deposition                              39 (65%)     49 (86%)     50 (86%)                                            
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (59)         (59)         (56)                                                
      Amyloid Deposition                              31 (53%)     49 (83%)     48 (86%)                                            
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Intestine Small, Ileum                             (59)         (58)         (54)                                                
      Amyloid Deposition                              46 (78%)     48 (83%)     43 (80%)                                            
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)                                                
      Amyloid Deposition                              22 (37%)     31 (52%)     28 (47%)                                            
      Basophilic Focus                                 1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                                           22 (37%)     22 (37%)                                            
      Fatty Change                                                               1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (3%)                                             
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                         2 (3%)       1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                    1 (2%)                                             
      Necrosis                                        10 (17%)     13 (22%)      8 (13%)                                            
      Centrilobular, Hypertrophy                      12 (20%)     46 (77%)     47 (78%)                                            
      Oval Cell, Hyperplasia                                        1 (2%)                                                          
   Pancreas                                           (60)         (60)         (60)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Duct, Cyst                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (60)         (60)         (60)                                                
      Amyloid Deposition                              32 (53%)     44 (73%)     44 (73%)                                            
   Stomach, Forestomach                               (60)         (60)         (60)                                                
      Acanthosis                                                    1 (2%)                                                          
      Amyloid Deposition                                                         4 (7%)                                             
      Hyperkeratosis                                                3 (5%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (59)         (60)                                                
      Amyloid Deposition                               8 (13%)     29 (49%)     22 (37%)                                            
      Mineralization                                                3 (5%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Amyloid Deposition                              43 (72%)     52 (87%)     52 (87%)                                            
      Degeneration                                     2 (3%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)      34 (57%)     35 (58%)                                            
      Valve, Thrombosis                                1 (2%)       2 (3%)                                                          
      Ventricle, Thrombosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)                                                
      Amyloid Deposition                              17 (28%)     37 (62%)     41 (68%)                                            
      Hyperplasia                                      4 (7%)                                                                       
      Capsule, Hyperplasia                             3 (5%)                                                                       
   Adrenal Medulla                                    (60)         (58)         (56)                                                
      Hyperplasia                                      2 (3%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)                                                
      Hyperplasia                                      4 (7%)                                                                       
   Parathyroid Gland                                  (54)         (52)         (52)                                                
      Amyloid Deposition                              10 (19%)     39 (75%)     42 (81%)                                            
   Thyroid Gland                                      (60)         (60)         (60)                                                
      Amyloid Deposition                              19 (32%)     48 (80%)     48 (80%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (60)         (59)         (58)                                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Suppurative                        5 (8%)       3 (5%)       1 (2%)                                             
   Seminal Vesicle                                    (60)         (59)         (60)                                                
      Fibrosis                                         1 (2%)                                                                       
   Testes                                             (60)         (60)         (60)                                                
      Edema                                            1 (2%)                                                                       
      Germinal Epithelium, Atrophy                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (7)          (7)          (4)                                                 
      Inguinal, Hyperplasia, Lymphoid                               1 (14%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                            1 (14%)                                                         
      Pancreatic, Inflammation, Granulomatous                       1 (14%)                                                         
      Renal, Hyperplasia, Lymphoid                     2 (29%)                                                                      
   Lymph Node, Mandibular                             (57)         (56)         (55)                                                
      Amyloid Deposition                               8 (14%)     29 (52%)     29 (53%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
   Lymph Node, Mesenteric                             (59)         (55)         (57)                                                
      Amyloid Deposition                              25 (42%)     36 (65%)     35 (61%)                                            
      Cyst                                             2 (3%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       2 (4%)                                             
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)                                                
      Amyloid Deposition                              16 (27%)     32 (53%)     30 (50%)                                            
      Hematopoietic Cell Proliferation                 3 (5%)       2 (3%)                                                          
      Hyperplasia, Lymphoid                            7 (12%)      4 (7%)       3 (5%)                                             
      Necrosis                                                                   1 (2%)                                             
      Capsule, Fibrosis                                             1 (2%)                                                          
   Thymus                                             (59)         (57)         (51)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Vein, Thrombosis                                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (59)                                                
      Edema                                            1 (2%)                                                                       
      Hyperkeratosis                                   2 (3%)                                                                       
      Ulcer                                            3 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (7)          (7)          (9)                                                 
      Axon, Degeneration                               2 (29%)      1 (14%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Fibrosis                                                     27 (45%)     25 (42%)                                            
      Inflammation, Chronic                            6 (10%)      3 (5%)       2 (3%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)       2 (3%)      11 (18%)                                            
      Thrombosis                                       1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       4 (7%)       3 (5%)                                             
      Alveolus, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)      31 (52%)     37 (62%)                                            
      Alveolus, Metaplasia, Osseous                    1 (2%)                                                                       
      Alveolus, Metaplasia, Squamous                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (4)          (1)          (6)                                                 
      External Ear, Ulcer                              1 (25%)                                                                      
   Eye                                                (2)          (1)          (1)                                                 
      Degeneration                                                               1 (100%)                                           
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Cyst                                                                       1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                          2 (3%)       1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous                      2 (3%)                                                                       
      Inflammation, Suppurative                                     1 (2%)       1 (2%)                                             
      Artery, Thrombosis                                            1 (2%)                                                          
      Glomerulus, Amyloid Deposition                  42 (70%)     35 (58%)     42 (70%)                                            
      Interstitium, Amyloid Deposition                 3 (5%)      14 (23%)     10 (17%)                                            
      Renal Tubule, Necrosis                                        1 (2%)                                                          
   Urethra                                            (1)                                                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05212-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:31  
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         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (100%)                                                                     
   Urinary Bladder                                    (60)         (59)         (59)                                                
      Calculus Gross Observation                                                 1 (2%)                                             
      Calculus Micro Observation Only                                            1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Suppurative                                                  2 (3%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)       2 (3%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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