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TDMS Study 05212-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                              OXAZEPAM


NTP Experiment-Test: 05212-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: DOSED FEED                                                                                                 Time: 11:54:34




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           13           11                                                  
    Natural Death                                      4           18           31                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           27           17                                                  
    Natural Death                                                   1                                                               
  Missing                                                           1            1                                                  
  Animals Examined Microscopically                    60           59           59                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (58)         (56)                                                
   Intestine Large, Cecum                             (58)         (56)         (51)                                                
   Intestine Small, Duodenum                          (59)         (56)         (56)                                                
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (59)         (56)                                                
      Carcinoma                                                                  1 (2%)                                             
   Liver                                              (60)         (59)         (59)                                                
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)       6 (10%)                                            
      Hepatocellular Carcinoma, Multiple                                         5 (8%)                                             
      Hepatocellular Adenoma                                        9 (15%)      8 (14%)                                            
      Hepatocellular Adenoma, Multiple                             13 (22%)     39 (66%)                                            
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Pancreas                                           (60)         (59)         (59)                                                
   Salivary Glands                                    (60)         (59)         (59)                                                
   Stomach, Glandular                                 (59)         (59)         (57)                                                
   Tooth                                              (2)                       (2)                                                 
      Adamantinoma NOS                                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (59)         (58)         (57)                                                
   Pituitary Gland                                    (57)         (58)         (58)                                                
   Thyroid Gland                                      (60)         (59)         (59)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (58)         (55)                                                
      Hemangioma                                       1 (2%)                    1 (2%)                                             
   Uterus                                             (60)         (59)         (57)                                                
      Polyp Stromal                                    1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (59)         (59)                                                
   Lymph Node                                         (8)          (10)         (7)                                                 
      Pancreatic, Histiocytic Sarcoma                                            1 (14%)                                            
   Lymph Node, Mandibular                             (58)         (57)         (58)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (57)         (56)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (60)         (59)         (59)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (56)         (57)         (55)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (59)         (59)                                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (59)                                                
      Alveolar/Bronchiolar Adenoma                     6 (10%)      4 (7%)       6 (10%)                                            
      Alveolar/Bronchiolar Carcinoma                   5 (8%)       3 (5%)       1 (2%)                                             
   Nose                                               (60)         (59)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (59)                                                
   Urinary Bladder                                    (59)         (59)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(59)        *(59)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         6 (10%)      8 (14%)      1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         3 (5%)       4 (7%)       5 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE FEMALE                 0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            24          37          49                                                   
     Total Primary Neoplasms                           26          46          75                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                  9          26          47                                                   
     Total Benign Neoplasms                             9          29          55                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          16          17                                                   
     Total Malignant Neoplasms                         16          17          20                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          1                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                10           13           24                                                  
    Natural Death                                      5           28           26                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           19           10                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (57)         (58)                                                
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (59)         (56)                                                
   Liver                                              (60)         (60)         (60)                                                
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                                      4 (7%)      13 (22%)                                            
      Hepatocellular Carcinoma, Multiple                            1 (2%)       6 (10%)                                            
      Hepatocellular Adenoma                           1 (2%)      14 (23%)      8 (13%)                                            
      Hepatocellular Adenoma, Multiple                             21 (35%)     42 (70%)                                            
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Pancreas                                           (60)         (60)         (60)                                                
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)         (60)                                                
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (59)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)                                                
      Adenoma                                          1 (2%)                                                                       
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Medulla                                    (60)         (58)         (56)                                                
   Thyroid Gland                                      (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (58)         (60)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Testes                                             (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)                                                
   Lymph Node                                         (7)          (7)          (4)                                                 
      Inguinal, Sarcoma, Metastatic, Skeletal                                                                                       
          Muscle                                       1 (14%)                                                                      
      Lumbar, Histiocytic Sarcoma                      1 (14%)                                                                      
      Mediastinal, Histiocytic Sarcoma                 1 (14%)                                                                      
      Pancreatic, Sarcoma, Metastatic, Skeletal                                                                                     
          Muscle                                       1 (14%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (14%)                                                                      
   Lymph Node, Mandibular                             (57)         (56)         (55)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (55)         (57)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Thymus                                             (59)         (57)         (51)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (59)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Neurofibrosarcoma                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (60)         (60)                                                
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Alveolar/Bronchiolar Adenoma                    10 (17%)      5 (8%)       7 (12%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   5 (8%)       3 (5%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Nose                                               (60)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Urinary Bladder                                    (60)         (59)         (59)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   2 (3%)       2 (3%)       2 (3%)                                             
      Lymphoma Malignant Mixed                         3 (5%)                    3 (5%)                                             
      Lymphoma Malignant Undifferentiated Cell         4 (7%)       5 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   8                                                               
NTP Experiment-Test: 05212-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/18/94  
Route: DOSED FEED                                                                                                 Time: 11:54:34  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS WEBSTER MICE MALE                   0 PPM        2500 PPM     5000 PPM                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            26          42          54                                                   
     Total Primary Neoplasms                           33          61          83                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          36          51                                                   
     Total Benign Neoplasms                            14          43          57                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          17          25                                                   
     Total Malignant Neoplasms                         19          18          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                                                                           
     Total Metastatic Neoplasm                          9                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   9                                                               
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                             ----------              END OF REPORT             ----------                                           
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