Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4687

TDMS Study 05212-04 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/18/94   
EXP: 05212                        OXAZEPAM                     TIME: 12:07:47   
TEST: 04              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 062453   
CONT: NO1ES85213                                               CAS: 604-75-1    
PATHOLOGIST: M. RYAN                         HAILEY, JAMESR.                    
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/18/94  
EXP: 05212                        OXAZEPAM                     TIME: 12:07:47  
TEST: 04              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 062453  
CONT: NO1ES85213                                               CAS: 604-75-1   
PATHOLOGIST: M. RYAN                         HAILEY, JAMESR.                   

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 397 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 45        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      161   244   257   279   281   281   293   295   327   327                 |
 |      331   338   344   358   371                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 41     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      14    107   145   159   183   206   225   268   295   296                 |
 |      296   297   305   312   317   327   328   329   331   336                 |
 |      339   340   341   341   350   351   356   359   360   361                 |
 |      362   365   369   375   376   379   382   383   385   387                 |
 |      393                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 50     CENSORED DEATHS 0    TERMINAL 10        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      57    165   225   231   237   271   271   272   273   281                 |
 |      285   286   292   296   302   302   305   306   310   311                 |
 |      314   328   328   334   341   341   344   345   351   355                 |
 |      358   361   362   363   364   365   368   369   370   370                 |
 |      371   371   373   374   375   379   383   385   385   395                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 397 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   397 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0  98.3  95.0  76.7  75.0  75.0  75.0  75.0  75.0  75.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |    98.3  93.3  86.7  46.7  31.7  31.7  31.7  31.7  31.7  31.7      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |    98.3  96.7  91.7  40.0  16.7  16.7  16.7  16.7  16.7  16.7      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            2500 PPM         5000 PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       75.0%            31.7%            16.7%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P<0.001          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       299.1            310.5            322.0         |
 |NATURAL DEATHS (C)      |       (13.8)           (13.2)           ( 8.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       372.5            337.9            334.5         |
 |(STANDARD ERROR)        |       ( 6.5)           (10.4)           ( 8.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 397 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 47        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      184   193   272   306   322   358   361   362   372   372                 |
 |      375   392   396                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2500 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 31     CENSORED DEATHS 1    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      106   160   239   256   281   291   294   294   309   315                 |
 |      320   320   321   322   326   326   328   330   336   344                 |
 |      349   350   363   367   372   374   376   389   392   393                 |
 |      394                                                                       |
 |  CENSORED DEATHS                                                               |
 |      17                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5000 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 42     CENSORED DEATHS 1    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      197   284   294   295   305   306   314   316   318   320                 |
 |      321   321   325   325   327   328   336   337   337   339                 |
 |      340   342   349   350   350   355   357   360   363   364                 |
 |      365   366   375   376   376   376   379   381   381   385                 |
 |      390   395                                                                 |
 |  CENSORED DEATHS                                                               |
 |      111                                                                       |
 |                                                                                |
 ==================================================================================

                                     OXAZEPAM


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 397 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   397 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0  96.7  86.7  78.3  78.3  78.3  78.3  78.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |2500 PPM   |   100.0  96.6  93.2  61.0  47.5  47.5  47.5  47.5  47.5  47.5      |
 |           |                                                                    |
 |           |                                                                    |
 |5000 PPM   |   100.0 100.0  98.3  47.5  28.8  28.8  28.8  28.8  28.8  28.8      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            2500 PPM         5000 PPM      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       78.3%            47.5%            28.8%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P<0.001          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       328.1            320.5            341.0         |
 |NATURAL DEATHS (C)      |       (19.7)           (11.5)           ( 5.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       382.1            351.2            353.0         |
 |(STANDARD ERROR)        |       ( 5.5)           ( 9.5)           ( 6.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                              OXAZEPAM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        2500 PPM         = 2
                                                        5000 PPM         = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 +  1   2             3                           1
      |      2             3             2         2   1 3                 3   1   1
      |                                            2   2                           1     1
      |                                                2       2     2     3 3         3 1 1
   90 +                                                              2     2               1 1
      |                                                                    2           2     1 1       1
      |                                                                                3   3
      |                                                                                                1 1 1
   80 +                                                                                    3 3 2 2         1 1
      |                                                                                      3 3 2 2 2       1   1 1
P     |                                                                                              2 2           1       1
E     |
R  70 +                                                                                          3 3   2 2
C     |                                                                                                  2 2
E     |                                                                                            3   3
N     |                                                                                                3 3
T  60 +                                                                                                  3 2 2
      |                                                                                                    3 2 2
S     |                                                                                                        2 2
U     |                                                                                                      3 3
R  50 +                                                                                                        3 3
V     |                                                                                                          2 2
I     |                                                                                                            2 2
V     |                                                                                                          3 3 2 2
A  40 +
L     |
      |                                                                                                                2 2
      |                                                                                                                  2 2
   30 +                                                                                                            3 3
      |
      |                                                                                                              3 3
      |
   20 +
      |                                                                                                                3   3
      |
      |
   10 +
      |
      ---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
         0         5        10        15        20        25        30        35        40        45        50        55        60

                                                                   WEEK

NOTE: 19 obs hidden.

                                                              OXAZEPAM
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        2500 PPM         = 2
                                                        5000 PPM         = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 +  1                               2                     1   3
      |                                  2             2       1 1 3           2       1   3 3
      |                                                                        2   2   1     3 3 1
      |                                                                            2       2 2 3 1   1           1
   90 +                                                                                          3 3
      |                                                                                      2     2 3           1   1
      |
      |                                                                                            2 2               1   1
P  80 +                                                                                              3 3                 1 1
E     |                                                                                              2 2                   1
R     |
C     |                                                                                                3 3
E  70 +                                                                                                2 2 3
N     |                                                                                                  2   2
T     |
      |                                                                                                    3 2   2
S  60 +                                                                                                          2 2 2
U     |                                                                                                      3 3
R     |                                                                                                        3 3   2   2
V     |
I  50 +                                                                                                          3 3     2 2
V     |                                                                                                                    2
A     |                                                                                                            3 3
L     |
   40 +                                                                                                              3 3
      |
      |
      |                                                                                                                3 3
   30 +                                                                                                                  3 3
      |
      |
      |
   20 +
      |
      ---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
         0         5        10        15        20        25        30        35        40        45        50        55        60

                                                                   WEEK

NOTE: 13 obs hidden.