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TDMS Study 05212-05 Pathology Tables

NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96
Route: DOSED FEED                                                                                                 Time: 15:50:37

                                                           CORE STUDY




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  05/12/94

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 004    625 PPM
                               Include 008    2500 PPM
                               Include 010    5000 PPM
                               Include 012    10,000  PPM STOP
                               Include 001    0 PPM
                               Include 003    625 PPM
                               Include 007    2500 PPM
                               Include 009    5000 PPM
                               Include 011    10,000  PPM STOP
























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1

NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Natural Death                                      6            6           12            3            6                        
    Moribund Sacrifice                                11           18           18           16           19                        
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           26           20           31           25                        
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (49)         (1)                       
      Periesophageal Tissue, Necrosis                                                                      1 (100%)                 
   Intestine Large, Colon                             (50)         (48)         (49)         (50)                                   
      Parasite Metazoan                                2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
   Intestine Large, Rectum                            (50)         (49)         (49)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Parasite Metazoan                                2 (4%)       2 (4%)       1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (47)         (49)                                   
      Ulcer                                                                      2 (4%)                                             
   Intestine Small, Jejunum                           (46)         (48)         (47)         (48)         (1)                       
      Parasite Metazoan                                                          1 (2%)                                             
      Ulcer                                                                                                1 (100%)                 
   Liver                                              (50)         (50)         (50)         (50)         (49)                      
      Basophilic Focus                                44 (88%)     41 (82%)     28 (56%)     26 (52%)     16 (33%)                  
      Clear Cell Focus                                 6 (12%)      3 (6%)      11 (22%)     22 (44%)                               
      Degeneration, Cystic                                                                                 2 (4%)                   
      Degeneration, Fatty                              1 (2%)                    2 (4%)                                             
      Eosinophilic Focus                              17 (34%)     18 (36%)      4 (8%)      11 (22%)     11 (22%)                  
      Hepatodiaphragmatic Nodule                      12 (24%)      2 (4%)       4 (8%)       5 (10%)      6 (12%)                  
      Inflammation, Granulomatous                      1 (2%)                    2 (4%)       3 (6%)                                
      Mixed Cell Focus                                 5 (10%)     15 (30%)      7 (14%)      3 (6%)       2 (4%)                   
      Necrosis, Focal                                                                         2 (4%)       1 (2%)                   
      Centrilobular, Atrophy                           1 (2%)                                                                       
      Centrilobular, Necrosis                                                    1 (2%)       2 (4%)       1 (2%)                   
      Hepatocyte, Centrilobular, Hypertrophy                                    10 (20%)     31 (62%)                               
   Mesentery                                          (10)         (9)          (4)          (6)          (13)                      
      Accessory Spleen                                 1 (10%)                                                                      
      Fat, Necrosis                                    8 (80%)      9 (100%)     4 (100%)     6 (100%)    13 (100%)                 
   Pancreas                                           (50)         (50)         (49)         (49)                                   
      Acinus, Atrophy                                  6 (12%)      6 (12%)      1 (2%)       8 (16%)                               
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (3)                       
      Abscess                                                                    1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                                      4 (8%)       1 (2%)                                
      Inflammation, Chronic Active                                  3 (6%)       4 (8%)       1 (2%)                                
      Ulcer                                            1 (2%)       2 (4%)       8 (16%)      6 (12%)      2 (67%)                  
      Epithelium, Hyperkeratosis                                                                           1 (33%)                  
      Epithelium, Hyperplasia                          1 (2%)       4 (8%)       8 (16%)      3 (6%)                                
      Epithelium, Ulcer                                                          1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (1)                       
      Erosion                                                       2 (4%)       1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)                    1 (2%)       2 (4%)                                
      Ulcer                                            2 (4%)       2 (4%)       6 (12%)                   1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (49)                                   
      Aorta, Mineralization                                                                   1 (2%)                                
   Heart                                              (50)         (50)         (49)         (49)                                   
      Atrium, Thrombosis                                            1 (2%)                                                          
      Myocardium, Degeneration                        32 (64%)     34 (68%)     35 (71%)     32 (65%)                               
      Myocardium, Fibrosis, Focal                                                             2 (4%)                                
      Myocardium, Mineralization                                                              1 (2%)                                
      Pericardium, Inflammation, Chronic               1 (2%)                                                                       
      Valve, Inflammation, Chronic                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (1)                       
      Degeneration                                                               1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Diffuse                                                                    1 (2%)                                
      Hyperplasia, Focal                               9 (18%)      8 (16%)      5 (10%)      4 (8%)                                
      Hypertrophy, Focal                                            2 (4%)                    1 (2%)                                
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Degeneration                                                               1 (2%)                                             
      Hyperplasia                                      8 (16%)      3 (6%)       1 (2%)       4 (8%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (49)                                   
      Hyperplasia                                      2 (4%)       1 (2%)                    1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (35)                      
      Angiectasis                                                                             2 (4%)                                
      Cyst                                             1 (2%)                                              2 (6%)                   
      Pars Distalis, Angiectasis                                    1 (2%)                                                          
      Pars Distalis, Cyst                              5 (10%)      2 (4%)       1 (2%)       3 (6%)       2 (6%)                   
      Pars Distalis, Degeneration, Cystic                                        1 (2%)       3 (6%)       5 (14%)                  
      Pars Distalis, Hyperplasia                       4 (8%)       5 (10%)      3 (6%)       8 (16%)      1 (3%)                   
      Pars Distalis, Vacuolization Cytoplasmic,                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
           Focal                                                                                           1 (3%)                   
   Thyroid Gland                                      (50)         (50)         (48)         (49)         (50)                      
      Ultimobranchial Cyst                                                                    1 (2%)                                
      C-Cell, Hyperplasia                             40 (80%)     43 (86%)     35 (73%)     42 (86%)     43 (86%)                  
      Follicle, Cyst                                                1 (2%)       2 (4%)       2 (4%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
      Inflammation, Granulomatous                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)         (11)                      
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Inflammation, Granulomatous                                                1 (2%)                                             
      Inflammation, Suppurative                                                                            1 (9%)                   
      Duct, Cyst                                       1 (2%)       4 (8%)       6 (12%)      2 (4%)       3 (27%)                  
   Ovary                                              (50)         (50)         (50)         (50)         (4)                       
      Cyst                                             5 (10%)      6 (12%)      5 (10%)      6 (12%)      4 (100%)                 
   Uterus                                             (50)         (50)         (50)         (50)         (5)                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                                            1 (20%)                  
      Cervix, Cyst                                     2 (4%)       1 (2%)       1 (2%)                    1 (20%)                  
      Cervix, Inflammation, Suppurative                                                                    1 (20%)                  
      Cervix, Myometrium, Hyperplasia                                                         2 (4%)       1 (20%)                  
      Endometrium, Hyperplasia, Cystic                 1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                                      1 (2%)                                                          
   Lymph Node                                         (4)          (2)          (9)          (3)          (4)                       
      Lumbar, Ectasia                                                            1 (11%)                                            
      Mediastinal, Pigmentation, Hemosiderin                                                  1 (33%)                               
      Pancreatic, Inflammation, Granulomatous                                    1 (11%)                                            
      Renal, Ectasia                                   1 (25%)                                                                      
   Lymph Node, Mandibular                             (50)         (48)         (48)         (49)         (3)                       
      Ectasia                                                       1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)         (2)                       
      Ectasia                                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Acute                              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (49)         (12)                      
      Fibrosis                                                      1 (2%)       2 (4%)       2 (4%)       2 (17%)                  
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)       3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)       1 (2%)       1 (8%)                   
      Pigmentation, Hemosiderin                       25 (50%)     27 (54%)     13 (26%)     22 (45%)                               
      Lymphoid Follicle, Atrophy                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (49)         (50)         (23)                      
      Hyperplasia, Cystic                              2 (4%)       3 (6%)       1 (2%)       1 (2%)       1 (4%)                   
      Metaplasia, Squamous                                                       1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)         (6)                       
      Hyperkeratosis                                                                                       1 (17%)                  
      Ulcer                                                                      2 (4%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                                                                      1 (17%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (1)                       
      Hyperostosis                                     1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                                                                                1 (100%)                 
      Osteopetrosis                                                              3 (6%)                                             
      Cranium, Hyperostosis, Focal                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hydrocephalus                                    7 (14%)     12 (24%)      3 (6%)       3 (6%)                                
      Cerebellum, Mineralization                                    1 (2%)                                                          
      Cerebrum, Degeneration, Focal                                              1 (2%)                                             
      Hypothalamus, Hemorrhage                         2 (4%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)                                   
      Congestion                                       1 (2%)                                                                       
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                                       2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Granulomatous                      2 (4%)       2 (4%)       5 (10%)      8 (16%)                               
      Alveolar Epithelium, Hyperplasia                 3 (6%)       4 (8%)       1 (2%)       3 (6%)                                
      Interstitium, Inflammation, Chronic              1 (2%)       2 (4%)                    2 (4%)                                
      Serosa, Inflammation, Chronic                    1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                        5 (10%)      2 (4%)       6 (12%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)                       (1)          (2)                       
      Choroid, Inflammation, Chronic                                                          1 (100%)                              
      Lens, Cataract                                   2 (100%)     1 (100%)                               2 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (1)                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      Nephropathy                                     32 (64%)     43 (86%)     41 (82%)     48 (96%)      1 (100%)                 
      Pigmentation, Lipofuscin                                                   2 (4%)                                             
      Renal Tubule, Cyst                                            1 (2%)       1 (2%)       1 (2%)                                
      Renal Tubule, Vacuolization Cytoplasmic                                                 1 (2%)                                
   Urinary Bladder                                    (48)         (49)         (49)         (50)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           27           33           43           39                        
    Natural Death                                      8           12           11            7           11                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                17           11            6                                                  
  Animals Examined Microscopically                    50           50           50           50           50                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (50)         (50)         (1)                       
      Parasite Metazoan                                             4 (9%)                    2 (4%)                                
      Serosa, Inflammation, Chronic                                                                        1 (100%)                 
   Intestine Large, Rectum                            (50)         (48)         (49)         (50)         (1)                       
      Congestion                                                                 1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Parasite Metazoan                                                          1 (2%)       2 (4%)                                
      Serosa, Inflammation, Chronic                                                                        1 (100%)                 
   Intestine Large, Cecum                             (50)         (48)         (49)         (50)         (1)                       
      Congestion                                                                 1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Serosa, Inflammation, Chronic                                                                        1 (100%)                 
   Intestine Small, Duodenum                          (50)         (48)         (49)         (50)                                   
      Erosion                                          2 (4%)                    6 (12%)      3 (6%)                                
      Ulcer                                            3 (6%)       3 (6%)       5 (10%)     13 (26%)                               
   Intestine Small, Ileum                             (50)         (47)         (46)         (49)                                   
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)         (50)         (50)                      
      Angiectasis                                      1 (2%)                                              1 (2%)                   
      Basophilic Focus                                21 (42%)     11 (22%)      4 (8%)       2 (4%)      13 (26%)                  
      Clear Cell Focus                                 2 (4%)       4 (8%)                                                          
      Degeneration, Cystic                             3 (6%)       1 (2%)       1 (2%)                                             
      Degeneration, Fatty                              1 (2%)                    1 (2%)                                             
      Eosinophilic Focus                               8 (16%)      5 (10%)      5 (10%)      6 (12%)      2 (4%)                   
      Hepatodiaphragmatic Nodule                       1 (2%)       3 (6%)       1 (2%)       2 (4%)       3 (6%)                   
      Mixed Cell Focus                                 2 (4%)       4 (8%)       2 (4%)       1 (2%)       1 (2%)                   
      Necrosis, Focal                                  1 (2%)                    5 (10%)      4 (8%)                                
      Bile Duct, Hyperplasia                           1 (2%)                    1 (2%)                                             
      Centrilobular, Congestion                                     1 (2%)                                                          
      Centrilobular, Degeneration                      1 (2%)                                 1 (2%)       1 (2%)                   
      Centrilobular, Necrosis                          3 (6%)       1 (2%)       4 (8%)       3 (6%)       2 (4%)                   
      Hepatocyte, Centrilobular, Hypertrophy                        1 (2%)       8 (16%)     14 (28%)                               
      Serosa, Fibrosis                                              1 (2%)                                                          
      Serosa, Inflammation, Chronic                                                                        1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (7)          (6)          (4)          (4)          (5)                       
      Accessory Spleen                                 1 (14%)      1 (17%)                                1 (20%)                  
      Necrosis, Acute, Focal                                        1 (17%)                                                         
      Fat, Necrosis                                    6 (86%)      3 (50%)      3 (75%)      4 (100%)     4 (80%)                  
   Pancreas                                           (50)         (48)         (49)         (50)                                   
      Acinus, Atrophy                                 17 (34%)     10 (21%)     14 (29%)      1 (2%)                                
      Acinus, Hyperplasia                                                                     1 (2%)                                
      Artery, Inflammation, Granulomatous              1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
      Parotid Gland, Degeneration                                                             1 (2%)                                
      Parotid Gland, Hyperplasia, Focal                                                       1 (2%)                                
   Stomach, Forestomach                               (50)         (48)         (50)         (50)         (10)                      
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)       2 (4%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)       4 (8%)       3 (6%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       5 (10%)      5 (10%)      1 (10%)                  
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            9 (18%)     12 (25%)     17 (34%)     11 (22%)      7 (70%)                  
      Epithelium, Hyperkeratosis                                                                           2 (20%)                  
      Epithelium, Hyperplasia                          1 (2%)       3 (6%)      11 (22%)     11 (22%)                               
   Stomach, Glandular                                 (50)         (48)         (50)         (50)         (4)                       
      Erosion                                          2 (4%)       1 (2%)       4 (8%)       3 (6%)                                
      Mineralization                                                3 (6%)       1 (2%)       4 (8%)       2 (50%)                  
      Ulcer                                            2 (4%)       6 (13%)     13 (26%)      5 (10%)      2 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)         (50)                                   
      Aorta, Mineralization                                         1 (2%)                    3 (6%)                                
      Aorta, Thrombosis                                1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (50)         (7)                       
      Atrium, Thrombosis                               7 (14%)                   1 (2%)                    5 (71%)                  
      Myocardium, Degeneration                        46 (92%)     40 (80%)     43 (86%)     37 (74%)      1 (14%)                  
      Myocardium, Mineralization                                    1 (2%)       2 (4%)       1 (2%)       4 (57%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic                                          1 (2%)                                                          
      Hyperplasia, Focal                               5 (10%)     10 (20%)      8 (16%)      6 (12%)                               
      Hypertrophy, Focal                                                         1 (2%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (1)                       
      Hyperplasia                                      9 (18%)      9 (18%)     15 (30%)     16 (32%)                               
   Islets, Pancreatic                                 (50)         (48)         (49)         (50)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      3 (6%)       2 (4%)                    1 (2%)                                
   Parathyroid Gland                                  (39)         (41)         (46)         (40)         (13)                      
      Hyperplasia                                      3 (8%)       6 (15%)      9 (20%)     16 (40%)     13 (100%)                 
   Pituitary Gland                                    (49)         (50)         (50)         (48)         (5)                       
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)                                                                       
      Pars Distalis, Cyst                                           2 (4%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                       9 (18%)      5 (10%)      3 (6%)       1 (2%)                                
      Pars Distalis, Thrombosis                        1 (2%)                                                                       
      Pars Nervosa, Gliosis, Focal                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)         (50)         (50)                      
      Mineralization                                                                          1 (2%)                                
      C-Cell, Hyperplasia                             33 (66%)     36 (73%)     38 (76%)     38 (76%)     41 (82%)                  
      Follicle, Cyst                                   4 (8%)       2 (4%)       4 (8%)       6 (12%)      9 (18%)                  
      Follicle, Hyperplasia                                                      1 (2%)                                             
      Follicle, Ultimobranchial Cyst                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (1)          (1)          (2)          (1)                       
      Inflammation, Chronic                                                                   1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)         (1)                       
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Preputial Gland                                    (48)         (50)         (50)         (49)         (14)                      
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                     2 (4%)                                 1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                    4 (8%)       3 (21%)                  
      Duct, Cyst                                       1 (2%)       4 (8%)       4 (8%)       3 (6%)       1 (7%)                   
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (50)         (1)                       
      Atrophy                                                                                              1 (100%)                 
      Cyst                                             1 (2%)                                 1 (2%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)         (48)                      
      Germinal Epithelium, Atrophy                     2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (5)          (8)          (8)          (1)          (9)                       
      Renal, Ectasia                                                             1 (13%)                                            
      Renal, Pigmentation                                                                                  1 (11%)                  
   Lymph Node, Mesenteric                             (49)         (49)         (50)         (47)         (4)                       
      Congestion                                                                 1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)         (33)                      
      Fibrosis                                         7 (14%)      3 (6%)       3 (6%)       4 (8%)       8 (24%)                  
      Hematopoietic Cell Proliferation                 6 (12%)      1 (2%)       3 (6%)       5 (10%)                               
      Necrosis                                         1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                                     1 (2%)       3 (6%)       2 (4%)                                
      Lymphoid Follicle, Atrophy                                    1 (2%)                    1 (2%)                                
      Red Pulp, Congestion                                          1 (2%)       1 (2%)       2 (4%)                                
   Thymus                                             (49)         (47)         (49)         (47)                                   
      Ectopic Parathyroid Gland                                                               2 (4%)                                
      Ectopic Thyroid                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (44)         (48)         (48)         (2)                       
      Hyperplasia, Cystic                              3 (6%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
   Skin                                               (50)         (49)         (49)         (50)         (8)                       
      Ulcer                                                                                   2 (4%)                                
      Epidermis, Cyst                                  1 (2%)                                                                       
      Epidermis, Inflammation, Suppurative                                                                 1 (13%)                  
      Hair Follicle, Cyst                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (4)                       
      Fibrosis                                                                                             1 (25%)                  
      Fibrous Osteodystrophy                                        1 (2%)       6 (12%)      8 (16%)      3 (75%)                  
      Hyperostosis                                     3 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (2)                       
      Hydrocephalus                                    6 (12%)      2 (4%)                    1 (2%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Hypothalamus, Degeneration                       1 (2%)                                                                       
      Medulla, Gliosis, Focal                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (3)                       
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Acute, Focal                                                              1 (2%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)       2 (4%)                    3 (6%)                                
      Metaplasia, Squamous                                                       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    1 (2%)                                
      Interstitium, Inflammation, Acute                1 (2%)                                                                       
      Interstitium, Inflammation, Chronic              2 (4%)                    3 (6%)                                             
      Interstitium, Inflammation, Chronic, Focal       1 (2%)                                                                       
      Interstitium, Mineralization                                  1 (2%)                    1 (2%)                                
      Mediastinum, Inflammation, Chronic                                                      1 (2%)                                
      Vein, Thrombosis                                 1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Suppurative                       13 (26%)     14 (28%)      9 (18%)      7 (14%)                               
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)          (1)          (2)                       
      Cataract                                                      1 (33%)                                                         
      Inflammation, Suppurative                                                               1 (100%)                              
      Anterior Chamber, Inflammation, Acute                         1 (33%)                                1 (50%)                  
      Anterior Chamber, Inflammation, Suppurative                                1 (50%)                                            
      Lens, Cataract                                   2 (100%)     1 (33%)      1 (50%)                   1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (42)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Fibrosis, Focal                                               1 (2%)                                                          
      Infarct                                          1 (2%)                                                                       
      Nephropathy                                     49 (98%)     44 (88%)     49 (98%)     50 (100%)    42 (100%)                 
      Renal Tubule, Cyst                               1 (2%)       1 (2%)       6 (12%)      8 (16%)      3 (7%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05212-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 07/19/96  
Route: DOSED FEED                                                                                                 Time: 15:50:37  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM     10,000                       
                                                                                                       PPM STOP                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Hyperplasia                                     1 (2%)       3 (6%)       1 (2%)                                
      Renal Tubule, Pigmentation, Lipofuscin           1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)         (50)         (1)                       
      Hemorrhage                                       1 (2%)                                                                       
      Ulcer                                                                                                1 (100%)                 
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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