Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/4649

TDMS Study 05212-05 Pathology Tables

NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96
Route: DOSED FEED                                                                                                 Time: 09:41:08

                                                   STANDARD TREATMENT GROUPS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  604-75-1

       Lock Date:  05/12/94

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 PPM
                               Include 002    0 PPM
                               Include 003    625 PPM
                               Include 004    625 PPM
                               Include 007    2500 PPM
                               Include 008    2500 PPM
                               Include 009    5000 PPM
                               Include 010    5000 PPM


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            6           12            3                                     
    Moribund Sacrifice                                11           18           18           16                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           26           20           31                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (48)         (49)         (50)                                   
      Polyp Adenomatous                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
   Mesentery                                          (10)         (9)          (4)          (6)                                    
   Pancreas                                           (50)         (50)         (49)         (49)                                   
      Acinus, Adenoma                                                                         1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Tongue                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                          1 (2%)       3 (6%)                    1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (38)         (38)         (33)                                   
      Adenoma                                                                    1 (3%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          30 (60%)     28 (56%)     20 (40%)     12 (24%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                    1 (2%)                                             
      Pars Distalis, Carcinoma                                                   1 (2%)                                             

                                                             Page   2                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (48)         (49)                                   
      C-Cell, Adenoma                                  6 (12%)      3 (6%)       6 (13%)      2 (4%)                                
      C-Cell, Carcinoma                                1 (2%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 2 (4%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                          6 (12%)      3 (6%)       3 (6%)       4 (8%)                                
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Tubulostromal Adenoma                                                                   1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Polyp Stromal                                    2 (4%)       4 (8%)       3 (6%)       4 (8%)                                
      Sarcoma Stromal                                  1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (4)          (2)          (9)          (3)                                    
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (25%)                                                                      
      Renal, Pheochromocytoma Malignant,                                                                                            
          Metastatic, Adrenal Medulla                  1 (25%)                                                                      
   Lymph Node, Mandibular                             (50)         (48)         (48)         (49)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (49)                                   
   Spleen                                             (50)         (50)         (50)         (49)                                   
   Thymus                                             (50)         (48)         (46)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (49)         (50)                                   
      Adenoma                                          1 (2%)       2 (4%)                                                          
      Carcinoma                                        2 (4%)       3 (6%)                                                          
      Fibroadenoma                                    11 (22%)     14 (29%)      8 (16%)     12 (24%)                               
      Fibroadenoma, Multiple                          14 (29%)      5 (10%)      1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   

                                                             Page   3                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Fibroma                                                                                 1 (2%)                                
      Fibrosarcoma                                                  2 (4%)                                                          
      Keratoacanthoma                                                                         1 (2%)                                
      Trichoepithelioma                                                          1 (2%)                                             
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Benign                                            1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)                                   
      Alveolar/Bronchiolar Adenoma                                                            2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (2)                                    
      Carcinoma                                                                               2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Nephroblastoma                                                1 (2%)                                                          
   Urinary Bladder                                    (48)         (49)         (49)         (50)                                   
      Sarcoma Stromal, Metastatic, Uterus                                                     1 (2%)                                
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            14 (28%)     19 (38%)     29 (58%)     18 (36%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          45          38                                       
     Total Primary Neoplasms                          101          93          80          67                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          39          30          26                                       
     Total Benign Neoplasms                            77          65          45          44                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          26          34          22                                       
     Total Malignant Neoplasms                         24          28          35          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       2           1                                       
     Total Metastatic Neoplasm                          2                       2           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           27           33           43                                     
    Natural Death                                      8           12           11            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                17           11            6                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (50)         (50)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (48)         (49)         (50)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (48)         (46)         (49)                                   
      Carcinoma                                        2 (4%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (49)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           1 (2%)                                 3 (6%)                                
   Mesentery                                          (7)          (6)          (4)          (4)                                    
      Leiomyosarcoma, Metastatic, Intestine Small,                                                                                  
           Jejunum                                     1 (14%)                                                                      
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                 1 (17%)                                                         
   Oral Mucosa                                                                  (1)                                                 
      Gingival, Squamous Cell Carcinoma                                          1 (100%)                                           
   Pancreas                                           (50)         (48)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
      Acinus, Adenoma                                  1 (2%)                    1 (2%)                                             
      Acinus, Adenoma, Mixed Cell                      1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (48)         (50)         (50)                                   
      Leiomyosarcoma                                                             1 (2%)                                             
   Stomach, Glandular                                 (50)         (48)         (50)         (50)                                   
      Leiomyosarcoma                                                1 (2%)                                                          
   Tongue                                                          (1)                       (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Tooth                                              (1)                                                                           
      Odontoma                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________

                                                             Page   7                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                          9 (18%)      8 (16%)      5 (10%)      1 (2%)                                
      Bilateral, Pheochromocytoma Benign               5 (10%)      1 (2%)       1 (2%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (48)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        2 (4%)                                                                       
   Pituitary Gland                                    (49)         (50)         (50)         (48)                                   
      Pars Distalis, Adenoma                          17 (35%)     12 (24%)      9 (18%)      2 (4%)                                
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                    2 (4%)                                             
      C-Cell, Adenoma                                  9 (18%)      5 (10%)      4 (8%)       2 (4%)                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       2 (4%)                                
      Follicular Cell, Carcinoma                       3 (6%)       3 (6%)       3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (2)          (1)          (1)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)         (50)                                   
   Preputial Gland                                    (48)         (50)         (50)         (49)                                   
      Adenoma                                          6 (13%)      9 (18%)      5 (10%)      3 (6%)                                
      Carcinoma                                        1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
      Bilateral, Adenoma                               1 (2%)                                 1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           35 (70%)     42 (84%)     47 (94%)     46 (92%)                               
      Interstitial Cell, Adenoma                      10 (20%)      6 (12%)      2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
   Lymph Node                                         (5)          (8)          (8)          (1)                                    
   Lymph Node, Mandibular                             (50)         (49)         (49)         (50)                                   
   Lymph Node, Mesenteric                             (49)         (49)         (50)         (47)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibroma                                          1 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Thymus                                             (49)         (47)         (49)         (47)                                   
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (44)         (48)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
      Fibroadenoma                                     4 (8%)       5 (11%)      4 (8%)       2 (4%)                                
   Skin                                               (50)         (49)         (49)         (50)                                   
      Fibroma                                          3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Fibrosarcoma                                     2 (4%)       3 (6%)                                                          
      Keratoacanthoma                                  3 (6%)       5 (10%)      1 (2%)       2 (4%)                                
      Keratoacanthoma, Multiple                                                               1 (2%)                                
      Liposarcoma                                                                             1 (2%)                                
      Osteosarcoma                                                               1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Schwannoma Malignant                             3 (6%)                                                                       
      Squamous Cell Papilloma                          2 (4%)                    1 (2%)                                             
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chordoma                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
      Oligodendroglioma Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Chordoma, Metastatic, Bone                                                 1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                       (1)                                    
      Carcinoma                                                     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Fibrous Histiocytoma, Metastatic, Lung                        1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)                    3 (6%)       1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leukemia Mononuclear                            27 (54%)     36 (72%)     33 (66%)     19 (38%)                               
      Mesothelioma Malignant                           2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05212-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                              OXAZEPAM                                         Date: 09/13/96  
Route: DOSED FEED                                                                                                 Time: 09:41:08  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        625 PPM      2500 PPM     5000 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          48                                       
     Total Primary Neoplasms                          160         151         135          99                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          50          47                                       
     Total Benign Neoplasms                           115          99          89          71                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          43          40          25                                       
     Total Malignant Neoplasms                         45          52          46          28                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1                                                   
     Total Metastatic Neoplasm                          3           8           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------