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TDMS Study 05214-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL


NTP Experiment-Test: 05214-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: GAVAGE                                                                                                     Time: 12:55:03




       Facility:  TSI Mason Research

       Chemical CAS #:  1972-08-3

       Lock Date:  06/01/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10            5           13           14                                     
    Moribund Sacrifice                                 3            5            3            3                                     
    Accidently Killed                                                                         1                                     
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           50           44           41                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Gallbladder                                        (53)         (59)         (54)         (54)                                   
   Intestine Large, Cecum                             (57)         (60)         (58)         (57)                                   
   Intestine Small, Jejunum                           (57)         (60)         (57)         (55)                                   
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Ileum                             (57)         (60)         (57)         (55)                                   
   Liver                                              (60)         (60)         (59)         (60)                                   
      Hepatocellular Carcinoma                         6 (10%)      5 (8%)       4 (7%)       1 (2%)                                
      Hepatocellular Adenoma                          13 (22%)      8 (13%)      7 (12%)      3 (5%)                                
      Hepatocellular Adenoma, Multiple                 4 (7%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Mesentery                                          (11)         (1)          (1)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                   1 (9%)                                                                       
   Pancreas                                           (59)         (60)         (59)         (57)                                   
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (58)         (60)         (58)         (57)                                   
      Squamous Cell Papilloma                          3 (5%)                                 2 (4%)                                
   Stomach, Glandular                                 (58)         (60)         (58)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
   Adrenal Medulla                                    (59)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Pituitary Gland                                    (55)         (58)         (58)         (57)                                   
      Pars Distalis, Adenoma                           9 (16%)      5 (9%)       2 (3%)       4 (7%)                                
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Follicular Cell, Adenoma                         4 (7%)       9 (15%)      3 (5%)       1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (59)         (56)         (54)                                   
   Ovary                                              (59)         (59)         (60)         (59)                                   
      Cystadenoma                                      1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (6)          (3)          (1)          (2)                                    
      Pancreatic, Fibrosarcoma, Metastatic, Skin       1 (17%)                                                                      
   Lymph Node, Mandibular                             (56)         (59)         (59)         (57)                                   
   Lymph Node, Mesenteric                             (57)         (60)         (57)         (53)                                   
   Spleen                                             (59)         (60)         (60)         (59)                                   
   Thymus                                             (59)         (58)         (56)         (58)                                   
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (59)         (60)         (59)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)         (60)                                   
      Ependymoma NOS                                                1 (2%)                                                          
   Peripheral Nerve                                   (60)         (60)         (60)         (59)                                   
   Spinal Cord                                        (60)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                    2 (3%)       2 (3%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (3%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                                                                       
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Nose                                               (59)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (1)          (1)          (1)                                    
      Adenoma                                          3 (100%)     1 (100%)     1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Urinary Bladder                                    (59)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   3 (5%)       1 (2%)       3 (5%)       2 (3%)                                
      Lymphoma Malignant Mixed                         7 (12%)      5 (8%)       1 (2%)       3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          31          26          16                                       
     Total Primary Neoplasms                           67          50          32          23                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          22          18          11                                       
     Total Benign Neoplasms                            40          31          20          15                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          14          12           6                                       
     Total Malignant Neoplasms                         27          18          12           8                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           1           1                                       
     Total Metastatic Neoplasm                          4           1           1           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           60           70           70                                     
  Scheduled Sacrifice                                 18                         9           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      9            5           11           21                                     
    Moribund Sacrifice                                 3            2            3            4                                     
    Accidently Killed                                                            2                                                  
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                50           53           45           33                                     
    Natural Death                                                                             1                                     
  Animals Examined Microscopically                    80           60           70           70                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (57)         (56)         (54)                                   
   Intestine Large, Rectum                            (60)         (57)         (56)         (54)                                   
      Anus, Squamous Cell Papilloma                    1 (2%)                                                                       
   Intestine Large, Cecum                             (60)         (57)         (56)         (55)                                   
   Intestine Small, Duodenum                          (60)         (57)         (54)         (54)                                   
      Adenoma                                                                    1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (57)         (53)         (53)                                   
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (60)         (57)         (54)         (54)                                   
      Sarcoma                                                                                 1 (2%)                                
   Liver                                              (62)         (60)         (61)         (57)                                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatoblastoma                                   2 (3%)                                                                       
      Hepatocellular Carcinoma                         9 (15%)      3 (5%)       5 (8%)       1 (2%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                                                                       
      Hepatocellular Adenoma                          16 (26%)     11 (18%)      5 (8%)       2 (4%)                                
      Hepatocellular Adenoma, Multiple                 9 (15%)                   1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Intestine Small, Ileum                                             1 (2%)                                
   Mesentery                                          (7)          (1)          (1)          (2)                                    
      Sarcoma, Metastatic, Intestine Small, Ileum                                             1 (50%)                               
   Pancreas                                           (62)         (59)         (61)         (57)                                   
      Sarcoma, Metastatic, Intestine Small, Ileum                                             1 (2%)                                
   Stomach, Forestomach                               (62)         (58)         (58)         (56)                                   
      Mast Cell Tumor NOS                                           1 (2%)                                                          
      Squamous Cell Papilloma                          3 (5%)       2 (3%)                    2 (4%)                                
   Stomach, Glandular                                 (62)         (58)         (57)         (56)                                   
                                                             Page   7                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (62)         (60)         (61)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (62)         (59)         (61)         (59)                                   
      Adenoma                                                                    1 (2%)                                             
      Capsule, Adenoma                                 1 (2%)                                                                       
      Capsule, Sarcoma, Metastatic, Intestine                                                                                       
          Small, Ileum                                                                        1 (2%)                                
   Adrenal Medulla                                    (61)         (59)         (61)         (58)                                   
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (59)         (57)         (59)         (53)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (62)         (60)         (61)         (57)                                   
      Follicular Cell, Adenoma                                      6 (10%)      3 (5%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (80)         (60)         (70)         (69)                                   
   Prostate                                           (62)         (60)         (62)         (60)                                   
   Seminal Vesicle                                    (62)         (60)         (62)         (57)                                   
   Testes                                             (80)         (60)         (70)         (69)                                   
      Interstitial Cell, Adenoma                                                 1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (62)         (60)         (60)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (3)                       (2)          (2)                                    
      Pancreatic, Sarcoma, Metastatic, Intestine                                                                                    
          Small, Ileum                                                                        1 (50%)                               
                                                             Page   8                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (54)         (50)         (54)         (53)                                   
   Lymph Node, Mesenteric                             (59)         (55)         (57)         (54)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
   Spleen                                             (62)         (59)         (61)         (59)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (58)         (50)         (55)         (52)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (62)         (60)         (61)         (61)                                   
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (62)         (60)         (60)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (62)         (60)         (61)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (60)         (60)         (61)         (60)                                   
   Spinal Cord                                        (62)         (60)         (61)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (62)         (60)         (61)         (59)                                   
      Alveolar/Bronchiolar Adenoma                    10 (16%)     10 (17%)      7 (11%)      7 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   4 (6%)       3 (5%)       1 (2%)       1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      4 (6%)                    1 (2%)                                             
   Nose                                               (62)         (59)         (61)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)          (4)          (5)          (2)                                    
      Adenoma                                          2 (100%)     3 (75%)      5 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (62)         (60)         (61)         (60)                                   
      Renal Tubule, Adenoma                                         1 (2%)                    1 (2%)                                
      Renal Tubule, Adenoma, Multiple                  1 (2%)                                                                       
   Urinary Bladder                                    (62)         (60)         (62)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(80)        *(60)        *(70)        *(70)                                   
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Lymphoma Malignant                                                         1 (1%)                                             
      Lymphoma Malignant Lymphocytic                   2 (3%)                                                                       
      Lymphoma Malignant Mixed                         4 (5%)       1 (2%)       3 (4%)       2 (3%)                                
      Lymphoma Malignant Undifferentiated Cell                                   1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05214-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:55:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            125          250          500                                       
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          33          27          18                                       
     Total Primary Neoplasms                           74          45          39          20                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          29          20          14                                       
     Total Benign Neoplasms                            47          37          25          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25           7          12           5                                       
     Total Malignant Neoplasms                         27           7          14           6                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5                       1           1                                       
     Total Metastatic Neoplasm                          6                       1           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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