TDMS Study 05214-02 Pathology Tables
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
Facility: TSI Mason Research
Chemical CAS #: 1972-08-3
Lock Date: 06/01/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 3| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 4| 4| 2| 3| 3| 0| 4| 5| 4| 4| 4| 1| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3|
| 0| 2| 0| 3| 3| 7| 7| 6| 1| 9| 0| 3| 0| 8| 2| 7| 1| 3| 1| 7| 0| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X |
Fatty Change | 1 2 1 1 1 |
Hematopoietic Cell Proliferation | 1 2|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 4 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 2 |
Arteriole, Infiltration Cellular, | |
Lymphocyte | 3 3|
Arteriole, Inflammation, Chronic | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 2 2 |
Inflammation, Chronic | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 3 2 |
Hyperplasia | 2 |
Mineralization | |
Ulcer | 1 |
Glands, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 3| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 4| 4| 2| 3| 3| 0| 4| 5| 4| 4| 4| 1| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3|
| 0| 2| 0| 3| 3| 7| 7| 6| 1| 9| 0| 3| 0| 8| 2| 7| 1| 3| 1| 7| 0| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + + + |
__________________________________________________________________________|
Tooth | + |
Abscess | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2|
Degeneration | 1 |
Inflammation, Chronic | 1 |
Valve, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Capsule, Hyperplasia | 3 2 2 2 2 1 2 2 2 1 1 2 2 1 2 2 1 2 1 1 1 1 2|
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 2 1 3 1 1 2 2 3 2|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + M M M + + + + + + + + M + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + M M + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 1 1 2 2 3 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 3 1 3 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + + + + + + + + + + + + + + + + M + + +|
Atrophy | 1 |
Hyperplasia, Squamous | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Angiectasis | 2 |
Cyst | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 3| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 4| 4| 2| 3| 3| 0| 4| 5| 4| 4| 4| 1| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3|
| 0| 2| 0| 3| 3| 7| 7| 6| 1| 9| 0| 3| 0| 8| 2| 7| 1| 3| 1| 7| 0| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Pigmentation | |
Periovarian Tissue, Cyst | X X |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 |
Inflammation, Acute | 2|
Endometrium, Atrophy | |
Endometrium, Hyperplasia, Cystic | 2 1 2 2 1 3 2 2 2 2 1 3 3 1 3 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 2 2 1 2 1 1 2 2 2 1 1 1 1|
Proliferation | |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Cyst | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Lymphoid Follicle, Atrophy | 2 2 2 2 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 2 2 2 1 2 2 1 1 1 2 2 2 2|
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 2 2 3 2 3 2 2 3 1 2 2 3 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 3| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 4| 4| 2| 3| 3| 0| 4| 5| 4| 4| 4| 1| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3|
| 0| 2| 0| 3| 3| 7| 7| 6| 1| 9| 0| 3| 0| 8| 2| 7| 1| 3| 1| 7| 0| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Mineralization | 1 2 2 2 1 2 1 1 1 2 1 1 2 2|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Perineural, Inflammation, Chronic | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Foreign Body | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 2 1 2 2 2 2 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Lumen, Exudate | 3 |
Nasolacrimal Duct, Hyperplasia | 2 |
Olfactory Epithelium, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 3| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 4| 4| 2| 3| 3| 0| 4| 5| 4| 4| 4| 1| 4| 3| 4| 4| 4| 3| 4| 4| 4| 3| 3|
| 0| 2| 0| 3| 3| 7| 7| 6| 1| 9| 0| 3| 0| 8| 2| 7| 1| 3| 1| 7| 0| 0| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 1 1 2 1|
Glomerulus, Amyloid Deposition | 3 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 1| 3| 4| 4| 3| 4| 4| 4| 7| 3| 4| 4| 4| 4| 8| 3| 4| 3| 3| 3| 4| 4| 3|
| 5| 0| 0| 7| 2| 1| 7| 2| 1| 1| 7| 7| 2| 3| 0| 1| 6| 2| 0| 7| 7| 7| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + A + + + M + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Fatty Change | 1 2 1 1 1 1 1 2 |
Hematopoietic Cell Proliferation | 1 1 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Mixed Cell Focus | X X |
Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 2 2 |
Arteriole, Infiltration Cellular, | |
Lymphocyte | |
Arteriole, Inflammation, Chronic | |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 1 1 2 2 4|
Inflammation, Chronic | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 2 2|
Mineralization | 1 |
Ulcer | |
Glands, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 1| 3| 4| 4| 3| 4| 4| 4| 7| 3| 4| 4| 4| 4| 8| 3| 4| 3| 3| 3| 4| 4| 3|
| 5| 0| 0| 7| 2| 1| 7| 2| 1| 1| 7| 7| 2| 3| 0| 1| 6| 2| 0| 7| 7| 7| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
Abscess | 3 |
Dysplasia | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 |
Degeneration | |
Inflammation, Chronic | |
Valve, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Capsule, Hyperplasia | 2 1 1 2 2 2 2 2 1 3 2 2 2 1 1 1 2 1 2 2 1 1 1 1|
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + A + + + + + + + + + + + + + +|
Pigmentation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M M + + + + M + + M + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X|
Pars Distalis, Hyperplasia | 2 1 3 3 2 3 2 3 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 2 2 2 1 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Squamous | 2|
Inflammation, Chronic | 1 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + A + + + + + + + + + + + + + +|
Abscess | 4 |
Angiectasis | 1 |
Cyst | X X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 1| 3| 4| 4| 3| 4| 4| 4| 7| 3| 4| 4| 4| 4| 8| 3| 4| 3| 3| 3| 4| 4| 3|
| 5| 0| 0| 7| 2| 1| 7| 2| 1| 1| 7| 7| 2| 3| 0| 1| 6| 2| 0| 7| 7| 7| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 1 |
Pigmentation | 2 |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Necrosis | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 4 4|
Inflammation, Acute | 4 |
Endometrium, Atrophy | 4|
Endometrium, Hyperplasia, Cystic | 2 2 3 2 1 1 3 4 2 2 2 1 2 3 3 2 3 3 3 4 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 |
Proliferation | 3 2|
__________________________________________________________________________|
Lymph Node | + +|
Lumbar, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + A + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + A + + M + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 3 |
Lymphoid Follicle, Atrophy | 3 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 1 2 2 2 2 1 2 1 1 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 2 3 2 3 2 2 3 2 2 2 1 3 2 2 3 2 3 2 3 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + A + + + + + + + + + + + + + +|
Cyst | X X X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 4 |
Inflammation, Chronic Active | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 1| 3| 4| 4| 3| 4| 4| 4| 7| 3| 4| 4| 4| 4| 8| 3| 4| 3| 3| 3| 4| 4| 3|
| 5| 0| 0| 7| 2| 1| 7| 2| 1| 1| 7| 7| 2| 3| 0| 1| 6| 2| 0| 7| 7| 7| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 2 |
Mineralization | 1 1 1 1 1 1 2 1 2 2 2 1 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Perineural, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | 2 1 2 |
Inflammation, Chronic | 1 2 2 1 1 1 2 2|
Inflammation, Chronic Active | |
Lumen, Exudate | 2 |
Nasolacrimal Duct, Hyperplasia | 1 |
Olfactory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 1| 3| 4| 4| 3| 4| 4| 4| 7| 3| 4| 4| 4| 4| 8| 3| 4| 3| 3| 3| 4| 4| 3|
| 5| 0| 0| 7| 2| 1| 7| 2| 1| 1| 7| 7| 2| 3| 0| 1| 6| 2| 0| 7| 7| 7| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 1 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Glomerulus, Amyloid Deposition | |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Necrosis | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 4| 3| 3| 7| 3| 4| 5| 4| 4| 4| | |
| 2| 7| 7| 7| 7| 0| 6| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + M + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 | 1 1.0|
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 9 |
Fatty Change | | 13 1.2|
Hematopoietic Cell Proliferation | 2 | 6 1.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Mixed Cell Focus | | 2 |
Necrosis | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Fat, Necrosis | 2 | 9 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | | 4 2.0|
Arteriole, Infiltration Cellular, | | |
Lymphocyte | | 2 3.0|
Arteriole, Inflammation, Chronic | | 1 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 4 3 2 4 2 | 15 2.3|
Inflammation, Chronic | | 1 2.0|
Ulcer | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 4| 3| 3| 7| 3| 4| 5| 4| 4| 4| | |
| 2| 7| 7| 7| 7| 0| 6| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 3 2.3|
Hyperplasia | | 3 2.0|
Mineralization | | 1 1.0|
Ulcer | | 1 1.0|
Glands, Dilatation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 4 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Abscess | | 1 3.0|
Dysplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 6 1.7|
Degeneration | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Valve, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 3 |
Capsule, Hyperplasia | 2 1 2 1 2 1 1 2 2 1 | 57 1.6|
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 1 3 1 1 1 | 29 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 55 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | 3 1 2 2 | 25 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 2 1 1 2 1 | 28 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 4| 3| 3| 7| 3| 4| 5| 4| 4| 4| | |
| 2| 7| 7| 7| 7| 0| 6| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Atrophy | | 1 1.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Abscess | | 2 4.0|
Angiectasis | | 2 1.5|
Cyst | | 3 |
Hemorrhage | 3 | 2 2.5|
Hyperplasia | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Pigmentation | | 1 2.0|
Periovarian Tissue, Cyst | | 3 |
Periovarian Tissue, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | 4 4 | 10 3.5|
Inflammation, Acute | | 2 3.0|
Endometrium, Atrophy | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 2 3 1 3 4 | 52 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | 1 1 1 3 1 | 35 1.3|
Proliferation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Lumbar, Cyst | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Lymphoid Follicle, Atrophy | 3 3 | 9 2.4|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 1 1 2 2 | 30 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 4| 3| 3| 7| 3| 4| 5| 4| 4| 4| | |
| 2| 7| 7| 7| 7| 0| 6| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 3 1 3 3 2 3 2 2 | 53 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | X X | 6 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Degeneration | 1 | 6 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Mineralization | 2 2 1 1 1 | 32 1.4|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 60 |
Degeneration | 1 | 1 1.0|
Perineural, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 60 |
Meninges, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Hemorrhage | | 3 1.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Bronchiole, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 4| 3| 3| 7| 3| 4| 5| 4| 4| 4| | |
| 2| 7| 7| 7| 7| 0| 6| 0| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Foreign Body | 3 | 1 3.0|
Inflammation, Acute | | 4 1.8|
Inflammation, Chronic | 1 1 1 | 24 1.4|
Inflammation, Chronic Active | 3 | 1 3.0|
Lumen, Exudate | | 2 2.5|
Nasolacrimal Duct, Hyperplasia | | 2 1.5|
Olfactory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 1 1 1 1 | 27 1.0|
Nephropathy | 2 1 1 2 1 3 1 | 39 1.2|
Glomerulus, Amyloid Deposition | | 1 3.0|
Renal Tubule, Degeneration, Hyaline | 2 | 1 2.0|
Renal Tubule, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 4| 4| 4| 4| 9| 0| 4| 6| 4| 4| 3| 4| 4| 4| 9| 4| 4| 4| 8| 1| 4|
| 7| 7| 4| 2| 0| 1| 2| 3| 9| 6| 2| 1| 2| 0| 7| 3| 1| 2| 2| 1| 2| 3| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Epithelium, Ulcer, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | X X |
Fatty Change | 2 2 |
Hematopoietic Cell Proliferation | 4 |
Infiltration Cellular, Lymphocyte | |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 2 4 3 |
Inflammation | 1 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 1 1 4 2 2 3 3 |
Ulcer | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 4| 4| 4| 4| 9| 0| 4| 6| 4| 4| 3| 4| 4| 4| 9| 4| 4| 4| 8| 1| 4|
| 7| 7| 4| 2| 0| 1| 2| 3| 9| 6| 2| 1| 2| 0| 7| 3| 1| 2| 2| 1| 2| 3| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Capsule, Hyperplasia | 2 1 1 1 2 2 1 1 2 2 2 1 1 1 1 2 2 2 1 2 2 1 2 1 2|
Capsule, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 2 3 1 2 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + M + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 1 1 1 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Hyperplasia | 2 1 1 2 1 1 1 2 1 1 2 4 1 2 1 1 1 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Dilatation | 2 1 |
Hyperplasia, Squamous | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4|
Cyst | |
Hemorrhage | |
Inflammation, Chronic | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 2|
Inflammation, Chronic | 4 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 2 1 1 1 1 1 1 2 1 1 2 1 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 1 2 1 1 1 2 1 2 1 2 1 2 |
Proliferation | X |
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 4| 4| 4| 4| 9| 0| 4| 6| 4| 4| 3| 4| 4| 4| 9| 4| 4| 4| 8| 1| 4|
| 7| 7| 4| 2| 0| 1| 2| 3| 9| 6| 2| 1| 2| 0| 7| 3| 1| 2| 2| 1| 2| 3| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 1 1 1 1 1 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 3 2 2 2 4 3 3 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hippocampus, Neuron, Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 9| 4| 4| 4| 4| 4| 9| 0| 4| 6| 4| 4| 3| 4| 4| 4| 9| 4| 4| 4| 8| 1| 4|
| 7| 7| 4| 2| 0| 1| 2| 3| 9| 6| 2| 1| 2| 0| 7| 3| 1| 2| 2| 1| 2| 3| 1| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
125 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 |
Inflammation, Chronic | 1 1 1 2 2 3 2 2 1 2 2 2 3|
Olfactory Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Chronic | |
Active | 4 |
Mucosa, Middle Ear, Hyperplasia | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 3| 2| 1| 0| 1| 1| 7| 2| 2| 2| 0| 1| 0| 3| 0| 1| 0| 1| 0| 0| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Epithelium, Ulcer, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X|
Clear Cell Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphocyte | 2 |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | 1 1|
Inflammation | |
Duct, Ectasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 3| 2| 1| 0| 1| 1| 7| 2| 2| 2| 0| 1| 0| 3| 0| 1| 0| 1| 0| 0| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Capsule, Hyperplasia | 1 2 2 2 1 1 1 2 2 2 2 1 2 2 2 2 2 1 2 2 1 2 1 2 2|
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 2 1 3 2 2 2 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 3 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Hyperplasia | 2 1 1 2 2 1 2 2 2 2 2 1 2 1 2 1 1 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia, Squamous | 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
Hemorrhage | |
Inflammation, Chronic | 4 |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 1 2 1 3 2 2 2 1 2 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
Proliferation | |
__________________________________________________________________________|
Lymph Node | + +|
Pancreatic, Hyperplasia, Lymphoid | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 3| 2| 1| 0| 1| 1| 7| 2| 2| 2| 0| 1| 0| 3| 0| 1| 0| 1| 0| 0| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 2 1 3 4 1 1 2|
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 2 2 2 1 2 3 1 2 2 2 2 1 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Hippocampus, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 1 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 3| 2| 1| 0| 1| 1| 7| 2| 2| 2| 0| 1| 0| 3| 0| 1| 0| 1| 0| 0| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 2 |
Inflammation, Chronic | 2 1 1|
Olfactory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Chronic | |
Active | |
Mucosa, Middle Ear, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 3| 3| 3| 4| 4| 4| | |
| 1| 0| 2| 1| 7| 7| 7| 1| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Epithelium, Ulcer, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Dysplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | | 3 |
Fatty Change | 1 | 3 1.7|
Hematopoietic Cell Proliferation | | 2 2.5|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Mixed Cell Focus | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 5 2.2|
Inflammation | | 1 1.0|
Duct, Ectasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | 3 | 11 2.5|
Ulcer | 2 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Dysplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 3| 3| 3| 4| 4| 4| | |
| 1| 0| 2| 1| 7| 7| 7| 1| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 2 | 4 1.3|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X | 2 |
Capsule, Hyperplasia | 2 2 1 2 1 3 2 1 2 1 | 60 1.6|
Capsule, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 1 2 3 | 33 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 54 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 1 1 2 1 | 19 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 | 3 1.0|
Follicular Cell, Hyperplasia | 4 2 1 1 1 2 1 4 2 | 46 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Dilatation | | 3 1.7|
Hyperplasia, Squamous | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Abscess | | 2 4.0|
Cyst | X | 1 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 3.0|
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 4 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 3| 3| 3| 4| 4| 4| | |
| 1| 0| 2| 1| 7| 7| 7| 1| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 2 2 2 2 | 53 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 1 1 1 1 1 2 2 2 | 40 1.3|
Proliferation | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Chronic | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Fibrosis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Lymphoid Follicle, Atrophy | | 1 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 1 | 18 1.6|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 3 1 2 3 1 | 37 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Cyst | X X X X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Fibrosis | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Degeneration | 1 | 3 1.3|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 4| 4| 4| 4| 3| 3| 3| 4| 4| 4| | |
| 1| 0| 2| 1| 7| 7| 7| 1| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 | 27 1.0|
Hippocampus, Neuron, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | 1 | 8 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | | 5 2.4|
Inflammation, Chronic | 1 1 1 1 1 1 | 22 1.5|
Olfactory Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Middle Ear, Inflammation, Chronic | | |
Active | | 1 4.0|
Mucosa, Middle Ear, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 | 17 1.0|
Nephropathy | 1 1 1 1 | 22 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 3 1.7|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 0| 7| 7| 7| 6| 7| 6| 7| 7| 3| 7| 5| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 4| 0| 4| 3| 0| 4| 3| 3| 7| 3| 5| 4| 4| 7| 4| 4| 6| 4| 4|
| 3| 2| 4| 1| 2| 1| 0| 9| 3| 5| 5| 2| 2| 7| 0| 7| 1| 0| 2| 4| 2| 8| 0| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A M + + M M + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Atrophy | |
Basophilic Focus | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Infarct | |
Mixed Cell Focus | |
Central Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 2 1 |
Inflammation, Chronic | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Erosion | 2 |
Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Atrium, Thrombosis | |
Valve, Bacterium | 3 4 |
Valve, Inflammation, Chronic | 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Capsule, Hyperplasia | 1 1 2 2 2 2 2 1 1 1 2 1 2 2 1 1 1 1 1 1 2 1 2 2|
Zona Reticularis, Hemorrhage | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 0| 7| 7| 7| 6| 7| 6| 7| 7| 3| 7| 5| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 4| 0| 4| 3| 0| 4| 3| 3| 7| 3| 5| 4| 4| 7| 4| 4| 6| 4| 4|
| 3| 2| 4| 1| 2| 1| 0| 9| 3| 5| 5| 2| 2| 7| 0| 7| 1| 0| 2| 4| 2| 8| 0| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + M + + + + + + M M + + M + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 2 1 1 1 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Cyst | |
Inflammation, Acute | 2 |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
Endometrium, Hyperplasia, Cystic | 1 2 1 2 1 1 2 1 1 1 2 1 2 2 1 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | A |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Myelofibrosis | 1 1 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + A + A + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | 1 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 2 1 4 2 2 1 1 |
Red Pulp, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 0| 7| 7| 7| 6| 7| 6| 7| 7| 3| 7| 5| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 4| 0| 4| 3| 0| 4| 3| 3| 7| 3| 5| 4| 4| 7| 4| 4| 6| 4| 4|
| 3| 2| 4| 1| 2| 1| 0| 9| 3| 5| 5| 2| 2| 7| 0| 7| 1| 0| 2| 4| 2| 8| 0| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 1 3 1 2 2 2 3 3 2 1 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + A + A + + + + + + + + + +|
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + M + + + + + + + + A + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 3 |
Inflammation, Chronic | 1 1 2 3 2 2 2 2 1 |
Nasolacrimal Duct, Hyperplasia | 2 |
Olfactory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
Nephropathy | 1 1 4 2 1 1 3 1 1 |
Pelvis, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 0| 7| 7| 7| 6| 7| 6| 7| 7| 3| 7| 5| 2| 7| 7|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 4| 0| 4| 3| 0| 4| 3| 3| 7| 3| 5| 4| 4| 7| 4| 4| 6| 4| 4|
| 3| 2| 4| 1| 2| 1| 0| 9| 3| 5| 5| 2| 2| 7| 0| 7| 1| 0| 2| 4| 2| 8| 0| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 3| 7| 7|
DAY ON TEST | 4| 4| 5| 4| 4| 4| 4| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 7| 0| 4| 3|
| 0| 1| 5| 1| 2| 4| 0| 7| 2| 3| 7| 2| 0| 7| 7| 0| 1| 3| 2| 3| 1| 4| 8| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Basophilic Focus | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 2 2 |
Infarct | X |
Mixed Cell Focus | |
Central Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 3 3 3 2 1 |
Inflammation, Chronic | 1 |
Ulcer | 2 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
Atrium, Thrombosis | X |
Valve, Bacterium | 3 |
Valve, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Capsule, Hyperplasia | 1 2 1 2 2 1 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2|
Zona Reticularis, Hemorrhage | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 3| 7| 7|
DAY ON TEST | 4| 4| 5| 4| 4| 4| 4| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 7| 0| 4| 3|
| 0| 1| 5| 1| 2| 4| 0| 7| 2| 3| 7| 2| 0| 7| 7| 0| 1| 3| 2| 3| 1| 4| 8| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + M + + + M + +|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 3 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1|
Follicular Cell, Hyperplasia | 2 2 2 1 1 1 2 1 1 2 1 1 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M M + + + + + + + + M + +|
Abscess | 4 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X |
Inflammation, Acute | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 |
Endometrium, Hyperplasia, Cystic | 2 1 1 1 1 2 1 1 1 1 2 2 2 3 1 1 2 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Myelofibrosis | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 1 3 1 2 2 3 |
Red Pulp, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 3| 7| 7|
DAY ON TEST | 4| 4| 5| 4| 4| 4| 4| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 7| 0| 4| 3|
| 0| 1| 5| 1| 2| 4| 0| 7| 2| 3| 7| 2| 0| 7| 7| 0| 1| 3| 2| 3| 1| 4| 8| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2 1 2 2 1 2 2 1 4 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 1 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 2 3 |
Inflammation, Chronic | 1 2 1 1 1 1 1 1|
Nasolacrimal Duct, Hyperplasia | |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
Nephropathy | 1 1 3 |
Pelvis, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 3| 7| 7|
DAY ON TEST | 4| 4| 5| 4| 4| 4| 4| 3| 4| 4| 3| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 7| 0| 4| 3|
| 0| 1| 5| 1| 2| 4| 0| 7| 2| 3| 7| 2| 0| 7| 7| 0| 1| 3| 2| 3| 1| 4| 8| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| | |
| 7| 3| 1| 1| 0| 0| 2| 1| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Basophilic Focus | | 1 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 2 2.0|
Infarct | | 1 |
Mixed Cell Focus | X X | 2 |
Central Vein, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperkeratosis | | 1 1.0|
Hyperplasia, Squamous | 1 4 2 | 10 2.2|
Inflammation, Chronic | | 1 1.0|
Ulcer | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Erosion | | 1 2.0|
Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 | 5 2.0|
Atrium, Thrombosis | | 1 |
Valve, Bacterium | | 3 3.3|
Valve, Inflammation, Chronic | | 3 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| | |
| 7| 3| 1| 1| 0| 0| 2| 1| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 2 2.0|
Capsule, Hyperplasia | 2 2 2 2 3 2 1 2 2 2 | 59 1.7|
Zona Reticularis, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | 2 1 3 1 1 | 19 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 2 | 10 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Follicular Cell, Hyperplasia | 1 1 1 1 3 1 2 | 40 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
Abscess | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Cyst | | 2 |
Inflammation, Acute | | 1 2.0|
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 5 2.6|
Endometrium, Hyperplasia, Cystic | 1 1 1 2 2 2 2 1 1 | 52 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Angiectasis | 3 | 1 3.0|
Myelofibrosis | 1 1 2 1 1 | 31 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| | |
| 7| 3| 1| 1| 0| 0| 2| 1| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Angiectasis | | 1 2.0|
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Lymphoid Follicle, Atrophy | | 2 1.5|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 2 2 | 17 1.9|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 1 2 1 1 1 | 28 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Cyst | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Degeneration | | 3 1.3|
Infiltration Cellular, Lymphocyte | | 2 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Mineralization | 1 1 1 1 1 | 25 1.1|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | 1 | 2 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | 1 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 4| 4| 4| 4| 4| 3| 4| 4| 4| | |
| 7| 3| 1| 1| 0| 0| 2| 1| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 | 19 1.4|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Olfactory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 | 6 1.0|
Nephropathy | 1 1 1 | 15 1.5|
Pelvis, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 5| 2| 7| 7| 2| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 7| 9| 6| 1| 4| 3| 1| 3| 4| 4| 4| 4| 7| 4| 4| 3| 4| 3| 9| 4| 4|
| 3| 0| 1| 1| 2| 5| 7| 0| 0| 7| 5| 7| 2| 3| 0| 2| 4| 1| 0| 7| 1| 7| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
500 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
Periesophageal Tissue, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + A + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Congestion | |
Eosinophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 1 1 |
Inflammation, Acute | 2 |
Necrosis | |
Bile Duct, Hyperplasia | |
Centrilobular, Fibrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Hyperplasia | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
Abscess | 3 |
Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | |
Epicardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 5| 2| 7| 7| 2| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 7| 9| 6| 1| 4| 3| 1| 3| 4| 4| 4| 4| 7| 4| 4| 3| 4| 3| 9| 4| 4|
| 3| 0| 1| 1| 2| 5| 7| 0| 0| 7| 5| 7| 2| 3| 0| 2| 4| 1| 0| 7| 1| 7| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
500 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Capsule, Hyperplasia | 1 3 1 1 1 1 1 2 1 2 1 2 2 1 1 2 1 1 1 2 1 2 1|
Zona Reticularis, Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | 1 |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | X X X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 3 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 1 2 1 3 1 1 1 1|
__________________________________________________________________________|
Lymph Node | |
Bronchial, Amyloid Deposition | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + M + + + + + + M + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 5| 2| 7| 7| 2| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 7| 9| 6| 1| 4| 3| 1| 3| 4| 4| 4| 4| 7| 4| 4| 3| 4| 3| 9| 4| 4|
| 3| 0| 1| 1| 2| 5| 7| 0| 0| 7| 5| 7| 2| 3| 0| 2| 4| 1| 0| 7| 1| 7| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
500 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M M + + + + + + + + + + M + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | 2 2 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 3 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 2 3 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Abscess | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + M + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hemorrhage | 2 2 2 2 |
Inflammation, Acute | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 3 1 1 1 1 |
Olfactory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 4| 5| 2| 7| 7| 2| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7|
DAY ON TEST | 4| 4| 0| 4| 7| 9| 6| 1| 4| 3| 1| 3| 4| 4| 4| 4| 7| 4| 4| 3| 4| 3| 9| 4| 4|
| 3| 0| 1| 1| 2| 5| 7| 0| 0| 7| 5| 7| 2| 3| 0| 2| 4| 1| 0| 7| 1| 7| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
500 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
Lens, Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
Mineralization | 1 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Bacterium | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 3| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 4| 0| 4| 2| 8| 3| 4|
| 0| 2| 3| 8| 7| 5| 7| 1| 3| 2| 2| 7| 2| 0| 0| 0| 0| 7| 2| 5| 1| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
Periesophageal Tissue, Inflammation, | |
Subacute | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + A + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + A + + + + + A + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Congestion | 3 |
Eosinophilic Focus | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Acute | |
Necrosis | |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Fibrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | 2 3 |
Duct, Ectasia | 1 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + A + + + + + + + A + + + + +|
Hyperplasia, Squamous | 1 2 2 3 2 |
Ulcer | 2 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + A + + + + + + + A + + + + +|
Dysplasia | |
Hyperplasia | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Abscess | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Inflammation, Chronic | 2 |
Epicardium, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 3| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 4| 0| 4| 2| 8| 3| 4|
| 0| 2| 3| 8| 7| 5| 7| 1| 3| 2| 2| 7| 2| 0| 0| 0| 0| 7| 2| 5| 1| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Capsule, Hyperplasia | 2 2 2 1 1 1 2 2 2 1 2 1 1 1 1 2 1 1 1 2 2 1 1 2|
Zona Reticularis, Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + A + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + M + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + I + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 3 2 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 3 1 2 1 2 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + + M + + + M + + + +|
Abscess | 2 |
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Periovarian Tissue, Cyst | X |
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 1 4 |
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 2 1 2 1 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + |
Bronchial, Amyloid Deposition | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 3| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 4| 0| 4| 2| 8| 3| 4|
| 0| 2| 3| 8| 7| 5| 7| 1| 3| 2| 2| 7| 2| 0| 0| 0| 0| 7| 2| 5| 1| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + M + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 2 1 1 1 2 1 1 1 2 2|
Red Pulp, Hematopoietic Cell | |
Proliferation | 1 2 2 2 3 1 2 1 3 1 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + A + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Hemorrhage | 1 2 1|
Inflammation, Acute | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 2 2 1 1 1 |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 0| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 3| 4| 3| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 2| 4| 0| 4| 2| 8| 3| 4|
| 0| 2| 3| 8| 7| 5| 7| 1| 3| 2| 2| 7| 2| 0| 0| 0| 0| 7| 2| 5| 1| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
500 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic Active | 4 |
Mineralization | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1|
Pelvis, Inflammation, Chronic | 2 |
Renal Tubule, Bacterium | X |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 4| 3| 4| 1| 3| 3| 8| 2| 4| | |
| 0| 2| 7| 3| 3| 7| 7| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 59 |
Perforation | | 1 |
Periesophageal Tissue, Inflammation, | | |
Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 |
Congestion | | 1 3.0|
Eosinophilic Focus | | 1 |
Fatty Change | 2 | 2 1.5|
Hematopoietic Cell Proliferation | | 3 1.7|
Inflammation, Acute | | 1 2.0|
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | | 1 1.0|
Centrilobular, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + | 57 |
Inflammation, Chronic | | 3 2.3|
Duct, Ectasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 57 |
Hyperplasia, Squamous | 2 3 4 | 9 2.2|
Ulcer | 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Dysplasia | 1 | 1 1.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + | 3 |
Abscess | | 1 3.0|
Dysplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 4| 3| 4| 1| 3| 3| 8| 2| 4| | |
| 0| 2| 7| 3| 3| 7| 7| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Epicardium, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 1 1.0|
Capsule, Hyperplasia | 2 1 1 2 1 1 1 2 1 2 | 57 1.4|
Zona Reticularis, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + | 56 |
Hyperplasia | 1 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M + M | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 57 |
Pars Distalis, Hyperplasia | 2 | 8 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 2 1 1 1 1 1 4 | 33 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + + + | 54 |
Abscess | | 1 2.0|
Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + | 59 |
Abscess | | 1 3.0|
Cyst | X | 6 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Periovarian Tissue, Cyst | | 2 |
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 4| 3| 4| 1| 3| 3| 8| 2| 4| | |
| 0| 2| 7| 3| 3| 7| 7| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 3 | 7 2.7|
Endometrium, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 | 39 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 2 1 1 | 23 1.3|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Bronchial, Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + M + | 53 |
Angiectasis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Lymphoid Follicle, Atrophy | | 4 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 2 2 3 2 1 1 | 19 1.6|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 3 1 1 1 1 1 | 23 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Abscess | | 1 2.0|
Cyst | X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Degeneration | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 6| 7| 7| | |
DAY ON TEST | 4| 4| 3| 4| 1| 3| 3| 8| 2| 4| | |
| 0| 2| 7| 3| 3| 7| 7| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
500 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Hemorrhage | 1 | 8 1.6|
Inflammation, Acute | | 1 4.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 1 | 18 1.3|
Olfactory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 2.0|
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Mineralization | | 3 1.0|
Nephropathy | 1 1 1 2 1 1 | 38 1.1|
Pelvis, Inflammation, Chronic | | 1 2.0|
Renal Tubule, Bacterium | | 1 |
Renal Tubule, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Dilatation | 4 | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 6| 6| 3| 0| 3| 4| 3| 3| 3| 6| 3| 7| 3| 3| 3| 5| 2|
| 4| 5| 4| 5| 5| 4| 0| 8| 3| 1| 0| 5| 4| 6| 1| 5| 0| 3| 6| 2| 0| 5| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M M + + A + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X |
Fatty Change | 1 1 2 2 1 2 1 2 |
Hematopoietic Cell Proliferation | 2 2 |
Infarct | |
Necrosis | |
Regeneration | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 3 |
Ulcer | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1|
Hyperplasia | 2|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
Abscess | 4 |
Dysplasia | 1 1 4 3 3 4 4 2 2 4 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 6| 6| 3| 0| 3| 4| 3| 3| 3| 6| 3| 7| 3| 3| 3| 5| 2|
| 4| 5| 4| 5| 5| 4| 0| 8| 3| 1| 0| 5| 4| 6| 1| 5| 0| 3| 6| 2| 0| 5| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | 1 2 |
Capsule, Hyperplasia | 3 1 1 2 1 1 1 1 1 2 4 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 3 4 3 2 2 3 2 4 1 1 4 2 4 4 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + + + + M + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 2 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 3 3 4 2 2 2 4 2 3 2 3 3 2|
Dilatation | 4 |
Inflammation, Chronic | 1 1 2 2 1 2 2 1 2 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration | |
Granuloma Sperm | |
Inflammation, Chronic | |
Mineralization | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 6| 6| 3| 0| 3| 4| 3| 3| 3| 6| 3| 7| 3| 3| 3| 5| 2|
| 4| 5| 4| 5| 5| 4| 0| 8| 3| 1| 0| 5| 4| 6| 1| 5| 0| 3| 6| 2| 0| 5| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | 2 |
Proliferation | X X |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + M + + + + M + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Atrophy | 3 2 2|
Congestion | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Lymphoid Follicle, Atrophy | 2|
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 1 1 2 2 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 1 2 3 2 2 1 2 3 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | |
Cyst | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + M + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 1 1 1 2 1 1 2 1 1 1 2 1 1|
Cerebrum, Neuron, Necrosis | |
Thalamus, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + +|
Degeneration | 1|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 4| 7| 6| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 6| 6| 3| 0| 3| 4| 3| 3| 3| 6| 3| 7| 3| 3| 3| 5| 2|
| 4| 5| 4| 5| 5| 4| 0| 8| 3| 1| 0| 5| 4| 6| 1| 5| 0| 3| 6| 2| 0| 5| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Hemorrhage | 1 1 |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 2 3 2 1 1 4 3|
Lumen, Foreign Body | 2 3 |
Nasolacrimal Duct, Hyperplasia | 2|
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Olfactory Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Fibrosis | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Nephropathy | 2 2 1 2 2 1 2 1 2 1 1 2 1 2 2 2 2 2 2 1 3|
Pelvis, Inflammation, Chronic | 1 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 6| 4| 7| 4| 4| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 6| 3| 3| 9| 6| 3| 3| 3| 3| 7| 6| 3| 6| 6| 8| 3| 3| 6| 3|
| 0| 0| 5| 1| 1| 1| 3| 0| 0| 1| 1| 5| 1| 1| 4| 8| 1| 0| 1| 3| 5| 0| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X |
Fatty Change | 1 2 1 1 1 2 1 1|
Hematopoietic Cell Proliferation | |
Infarct | X X |
Necrosis | 3 3 |
Regeneration | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Hyperplasia, Lymphoid | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia | |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Dysplasia | 1 2 1 1 2 3 3 2 2 1 1 2 3 2 1 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 6| 4| 7| 4| 4| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 6| 3| 3| 9| 6| 3| 3| 3| 3| 7| 6| 3| 6| 6| 8| 3| 3| 6| 3|
| 0| 0| 5| 1| 1| 1| 3| 0| 0| 1| 1| 5| 1| 1| 4| 8| 1| 0| 1| 3| 5| 0| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 |
Hypertrophy | 2 1 1 1 |
Capsule, Hyperplasia | 1 2 1 1 1 1 1 1 1 1 1 3 1 1 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 3 2 1 2 3 4 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 3 2 4 3 3 2 3 2 1 2 3 4 3 4 3 2|
Dilatation | 3 4 |
Inflammation, Chronic | 4 1 2 1 2 2 1 2 2 1 1 2 1 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Fibrosis | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | 2 |
Granuloma Sperm | |
Inflammation, Chronic | 2 |
Mineralization | 2 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 6| 4| 7| 4| 4| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 6| 3| 3| 9| 6| 3| 3| 3| 3| 7| 6| 3| 6| 6| 8| 3| 3| 6| 3|
| 0| 0| 5| 1| 1| 1| 3| 0| 0| 1| 1| 5| 1| 1| 4| 8| 1| 0| 1| 3| 5| 0| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Proliferation | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + M + +|
Angiectasis | |
Atrophy | |
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Lymphoid Follicle, Atrophy | 1 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 1 2 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 3 2 4 1 3 1 2 2 1 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + + + M + + +|
Angiectasis | 3 |
Cyst | X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 1 2 2 1 2 2 |
Cerebrum, Neuron, Necrosis | |
Thalamus, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 4| 7| 7| 5| 4| 7| 7| 7| 7| 6| 4| 7| 4| 4| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 6| 3| 3| 9| 6| 3| 3| 3| 3| 7| 6| 3| 6| 6| 8| 3| 3| 6| 3|
| 0| 0| 5| 1| 1| 1| 3| 0| 0| 1| 1| 5| 1| 1| 4| 8| 1| 0| 1| 3| 5| 0| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 2 2 |
Lumen, Foreign Body | |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hematopoietic Cell Proliferation | |
Metaplasia, Osseous | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 3 1 2 1 2 2 1 1 1 3 2 2 1 1 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 6| 3| 6| 6| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 6| 6| 3|
| 3| 1| 1| 1| 6| 4| 0| 4| 5| 1| 4| 1| 6| 4| 2| 7| 6| 1| 8| 6| 5| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X |
Fatty Change | 1 2 1 2 |
Hematopoietic Cell Proliferation | |
Infarct | |
Necrosis | |
Regeneration | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Mineralization | |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia, Squamous | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + +|
Abscess | 4 |
Dysplasia | 3 3 4 3 3 4 2 1 3 3 4 4 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 6| 3| 6| 6| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 6| 6| 3|
| 3| 1| 1| 1| 6| 4| 0| 4| 5| 1| 4| 1| 6| 4| 2| 7| 6| 1| 8| 6| 5| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 1 2|
Hypertrophy | 1 1 1 1 |
Capsule, Hyperplasia | 1 1 2 1 3 1 1 1 1 2 2 1 2 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 4 4 2 2 1 4|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + M M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 3 3 4 2 4 3 3 3 2 3 2 4 3 2 2|
Dilatation | |
Inflammation, Chronic | 1 2 1 3 2 4 2 1 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Concretion | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 |
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Degeneration | 2 3 |
Granuloma Sperm | 3 |
Inflammation, Chronic | |
Mineralization | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 6| 3| 6| 6| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 6| 6| 3|
| 3| 1| 1| 1| 6| 4| 0| 4| 5| 1| 4| 1| 6| 4| 2| 7| 6| 1| 8| 6| 5| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Proliferation | X 1 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Atrophy | |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 1 2 2 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 3 3 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
Degeneration | 2 1 2 1 |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 2 1 1 2 2 1 2 1 1|
Cerebrum, Neuron, Necrosis | 3 |
Thalamus, Neuron, Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + M + + + + + + + + +|
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 4| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7|
DAY ON TEST | 6| 3| 6| 6| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 6| 6| 3|
| 3| 1| 1| 1| 6| 4| 0| 4| 5| 1| 4| 1| 6| 4| 2| 7| 6| 1| 8| 6| 5| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 4 |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 1 2 1 2 1 2 1 1|
Lumen, Foreign Body | |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
Olfactory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | X|
Hematopoietic Cell Proliferation | |
Metaplasia, Osseous | 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 2 2 1 1 1 1 2 2 2 2 2 2 2 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| | |
| 3| 0| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 | 7| 7| 7| 7| 8| | L |
MG/KG | 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 62 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 60 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + | 62 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 2 |
Clear Cell Focus | | 7 |
Eosinophilic Focus | X | 18 |
Fatty Change | | 20 1.4|
Hematopoietic Cell Proliferation | | 2 2.0|
Infarct | | 2 |
Necrosis | | 2 3.0|
Regeneration | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Fat, Necrosis | 2 | 6 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + | 62 |
Atrophy | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 62 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 62 |
Hyperplasia, Squamous | 4 | 7 2.7|
Ulcer | 3 | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 62 |
Erosion | | 3 1.0|
Hyperplasia | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + | 48 |
Abscess | | 3 3.0|
Dysplasia | 2 2 2 4 | 46 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| | |
| 3| 0| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 | 7| 7| 7| 7| 8| | L |
MG/KG | 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 62 |
Cardiomyopathy | 2 | 6 1.8|
Mineralization | | 1 1.0|
Endothelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 62 |
Hyperplasia | 1 3 2 | 14 1.6|
Hypertrophy | | 10 1.2|
Capsule, Hyperplasia | 2 2 2 | 52 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 61 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 62 |
Hyperplasia | 2 1 3 4 | 41 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 59 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 | 9 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 62 |
Follicular Cell, Hyperplasia | 1 1 1 | 16 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 80 |
Granuloma Sperm | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 62 |
Abscess | | 1 4.0|
Atrophy | 3 | 46 2.8|
Dilatation | | 3 3.7|
Inflammation, Chronic | 2 1 4 | 36 1.8|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + | 62 |
Concretion | | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 62 |
Dilatation | 4 3 | 7 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| | |
| 3| 0| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 | 7| 7| 7| 7| 8| | L |
MG/KG | 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + | 80 |
Atrophy | | 1 2.0|
Degeneration | | 3 2.3|
Granuloma Sperm | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 62 |
Hyperplasia, Megakaryocyte | | 1 2.0|
Proliferation | | 8 1.8|
__________________________________________________________________________|____________|
Lymph Node | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 54 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 59 |
Angiectasis | | 5 2.0|
Atrophy | | 3 2.3|
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 62 |
Angiectasis | | 1 3.0|
Lymphoid Follicle, Atrophy | | 4 2.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 | 17 1.6|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 1 2 | 33 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + | 58 |
Angiectasis | | 1 3.0|
Cyst | | 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M | 51 |
__________________________________________________________________________|____________|
Skin | + + + + | 62 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| | |
| 3| 0| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 | 7| 7| 7| 7| 8| | L |
MG/KG | 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 62 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 62 |
Degeneration | | 10 1.4|
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 62 |
Mineralization | 2 2 2 | 42 1.4|
Cerebrum, Neuron, Necrosis | | 1 3.0|
Thalamus, Neuron, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + | 60 |
Degeneration | | 2 1.5|
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 62 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 62 |
Edema | | 2 2.0|
Hemorrhage | | 3 1.0|
Inflammation, Chronic | | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 5 2.8|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + | 62 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 1 | 26 1.6|
Lumen, Foreign Body | | 2 2.5|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 2 2.0|
Olfactory Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 62 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Fibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| | |
| 3| 0| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| | A |
0 | 7| 7| 7| 7| 8| | L |
MG/KG | 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 62 |
Cyst | X | 12 |
Hematopoietic Cell Proliferation | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 1 1 1 1 | 55 1.0|
Nephropathy | 1 1 1 2 | 61 1.6|
Pelvis, Inflammation, Chronic | | 1 1.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 62 |
Dilatation | 4 | 6 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 0| 1| 5| 0| 4| 6| 1| 0| 5| 4| 0| 5| 6| 4| 5| 6| 0| 1| 6| 8| 5| 6| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M A + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + A + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + A + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Squamous | 4 3 4 4 2 3 2 2 2 3 4 2 4 4 4|
Infiltration Cellular, Lymphocyte | |
Ulcer | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Erosion | 2 |
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Tongue | + + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + |
Abscess | |
Dysplasia | 1 1 1 1 1 1 1 1 2 2 1 1 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Cardiomyopathy | 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 0| 1| 5| 0| 4| 6| 1| 0| 5| 4| 0| 5| 6| 4| 5| 6| 0| 1| 6| 8| 5| 6| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 |
Hypertrophy | 1 |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + M + + + + + M + M + + M M M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 1 1 2 1 2 1 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 3 4 3 2 2 1 2 2 2 2 2 |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 4 2 3 2 3 1 4 2 1 3 2 1 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 1 |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 0| 1| 5| 0| 4| 6| 1| 0| 5| 4| 0| 5| 6| 4| 5| 6| 0| 1| 6| 8| 5| 6| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 |
Atrophy | |
Ectasia | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 1 1 1 1 1 1 1 2 1 1|
Red Pulp, Hematopoietic Cell | |
Proliferation | 3 3 2 2 2 2 1|
__________________________________________________________________________|
Thymus | + M + + + + + + M + + + + + + + + + + M + + M + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 1 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Leukocytosis | 3 |
Bronchiole, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 0| 1| 5| 0| 4| 6| 1| 0| 5| 4| 0| 5| 6| 4| 5| 6| 0| 1| 6| 8| 5| 6| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
125 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 2 2 1 1 1 1 |
Nasolacrimal Duct, Hyperplasia | 1 2 |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 4 3 |
Cyst | |
Inflammation, Chronic Active | 4 1 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Pelvis, Inflammation, Chronic | |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 1| 0| 4| 0| 8| 6| 6| 0| 1| 1| 4| 1| 1| 1| 6| 1| 0| 5| 4| 1| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change | 1 2 1 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 2|
Mixed Cell Focus | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 4 3 3 4 1 2 3 2 2 2 2 2|
Infiltration Cellular, Lymphocyte | |
Ulcer | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 3 |
Dysplasia | 3 1 2 3 1 1 1 1 2 4 3 2 2 1 1 3 1 2 1 1 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 1| 0| 4| 0| 8| 6| 6| 0| 1| 1| 4| 1| 1| 1| 6| 1| 0| 5| 4| 1| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 |
Hypertrophy | 1 1 1 |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 2 1 1 1 2 1 3 3 2|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M + + + + + + + M M + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 1 1 4 1 1 2 1 1 1 2 3 1 3 2 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 2 3 2 1 2 2 1 1 1 2 2 2 2 3 2 2 4 2|
Hyperplasia | 1 |
Inflammation, Chronic | 2 2 2 1 2 2 1 1 3 1 1 3 3 2 3 2 2 4 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Hyperplasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + + + + + M + + M + + + + M + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 1| 0| 4| 0| 8| 6| 6| 0| 1| 1| 4| 1| 1| 1| 6| 1| 0| 5| 4| 1| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + M + + + + + + + + M + + +|
Angiectasis | 2 |
Atrophy | 2 |
Ectasia | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | 4 |
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 1 1 1 1 1 1 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 4 1 1 2 2 3 1|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + M + M + + + + + + + M + +|
Cyst | X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M + M M + M + + + M + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Leukocytosis | |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 4| 1| 0| 4| 0| 8| 6| 6| 0| 1| 1| 4| 1| 1| 1| 6| 1| 0| 5| 4| 1| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
125 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 3 1 1 2 1 2 1 1 1 2 |
Nasolacrimal Duct, Hyperplasia | |
Olfactory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | X |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cyst | X X |
Inflammation, Chronic Active | |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation, Chronic | 1 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 3| 1| 6| 9| 6| 5| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + | 57 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + | 57 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change | 1 2 | 11 1.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 | 4 1.5|
Mixed Cell Focus | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + | 59 |
Atrophy | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + | 58 |
Hyperplasia, Squamous | 1 3 2 3 | 33 2.8|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Ulcer | 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + | 58 |
Erosion | | 1 2.0|
Hyperplasia | | 2 2.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 3 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + | 48 |
Abscess | | 2 3.5|
Dysplasia | 2 1 1 1 1 1 2 1 | 47 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 3| 1| 6| 9| 6| 5| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Bacterium | | 1 2.0|
Cardiomyopathy | | 9 1.4|
Inflammation, Acute | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 8 1.6|
Hypertrophy | 1 1 | 6 1.0|
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 2 | 50 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + | 59 |
Hyperplasia | 2 2 4 1 | 27 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 47 |
Cyst | X | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 1 1 2 2 2 | 48 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | 3 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Abscess | | 1 4.0|
Atrophy | 3 3 3 2 3 1 2 2 | 37 2.2|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | 3 3 2 1 2 1 2 | 43 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Concretion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 3| 1| 6| 9| 6| 5| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Proliferation | 1 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + + | 55 |
Angiectasis | | 2 2.0|
Atrophy | | 1 2.0|
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + M + + + + + + + + | 59 |
Capsule, Inflammation, Chronic | | 1 4.0|
Lymphoid Follicle, Atrophy | | 1 3.0|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 | 20 1.1|
Red Pulp, Hematopoietic Cell | | |
Proliferation | | 14 2.1|
__________________________________________________________________________|____________|
Thymus | + A + + + + + M + + | 50 |
Cyst | X X X X | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M M M M + + + | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 3| 1| 6| 9| 6| 5| 4| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
125 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Degeneration | | 7 1.0|
Infiltration Cellular, Lymphocyte | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Mineralization | 1 1 1 2 1 1 | 33 1.1|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 4 1.0|
Leukocytosis | | 1 3.0|
Bronchiole, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + | 59 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 | 23 1.3|
Nasolacrimal Duct, Hyperplasia | | 2 1.5|
Olfactory Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Phthisis Bulbi | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 2 3.5|
Cyst | | 2 |
Inflammation, Chronic Active | | 2 2.5|
Mineralization | 1 1 1 1 1 1 1 1 1 | 56 1.0|
Nephropathy | 1 3 1 1 1 1 1 1 | 50 1.1|
Pelvis, Inflammation, Chronic | 2 | 2 1.5|
Renal Tubule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 7| 0| 7| 7| 7| 3| 7| 4| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 0| 2| 3| 7| 3| 9| 3| 3| 3| 9| 3| 6| 3| 3| 4| 3| 2| 1| 3| 3| 3| 3|
| 6| 4| 1| 5| 5| 0| 0| 6| 4| 5| 6| 0| 5| 6| 1| 0| 1| 6| 1| 8| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + M M + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + A + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + A + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A + + + + + + + + + A + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + A + A + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + A + A + + + A + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + A + A + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 1 2 |
Hemorrhage | |
Mixed Cell Focus | |
Bile Duct, Dilatation | 3|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Arteriole, Inflammation, Chronic | 2 |
Arteriole, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Squamous | 2 1 3 2 2 1 2 4 1 2 4 4 2|
Ulcer | 2 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + M + + + + + + + A + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | + + |
Dysplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + +|
Dysplasia | 1 1 1 1 1 2 1 1 1 2 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 |
Inflammation, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 7| 0| 7| 7| 7| 3| 7| 4| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 0| 2| 3| 7| 3| 9| 3| 3| 3| 9| 3| 6| 3| 3| 4| 3| 2| 1| 3| 3| 3| 3|
| 6| 4| 1| 5| 5| 0| 0| 6| 4| 5| 6| 0| 5| 6| 1| 0| 1| 6| 1| 8| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 2 4 1 1 4 3 2 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + +|
Abscess | 4 |
Atrophy | 3 3 2 1 2 1 2 2 2|
Dilatation | |
Inflammation, Chronic | 1 1 2 1 3 1 4 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + +|
Myelofibrosis | |
Proliferation | 3 2 2|
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + + + + + +|
Atrophy | 2 2 2 |
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + M + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | 2 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 7| 0| 7| 7| 7| 3| 7| 4| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 0| 2| 3| 7| 3| 9| 3| 3| 3| 9| 3| 6| 3| 3| 4| 3| 2| 1| 3| 3| 3| 3|
| 6| 4| 1| 5| 5| 0| 0| 6| 4| 5| 6| 0| 5| 6| 1| 0| 1| 6| 1| 8| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Red Pulp, Hematopoietic Cell | |
Proliferation | 1 1 4 1 2 4 1 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + M + + + M + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Subcutaneous Tissue, Foreign Body | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 2 2 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1|
Olfactory Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 7| 0| 7| 7| 7| 3| 7| 4| 7| 7| 2| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 0| 2| 3| 7| 3| 9| 3| 3| 3| 9| 3| 6| 3| 3| 4| 3| 2| 1| 3| 3| 3| 3|
| 6| 4| 1| 5| 5| 0| 0| 6| 4| 5| 6| 0| 5| 6| 1| 0| 1| 6| 1| 8| 1| 1| 1| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Inflammation, Chronic Active | 4 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 2 1 1 1 1 1 1 1 1 1 3 1 1 1|
Pelvis, Inflammation, Chronic | 2 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Bacterium | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 2 |
Transitional Epithelium, Bacterium | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3|
| 4| 3| 5| 0| 4| 1| 1| 1| 5| 0| 1| 0| 1| 6| 0| 1| 6| 1| 5| 6| 4| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Mixed Cell Focus | X X|
Bile Duct, Dilatation | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Arteriole, Inflammation, Chronic | |
Arteriole, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Squamous | 2 3 2 3 2 2 2 3 2 2 2 1 2 1 3|
Ulcer | 2 2 3 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tongue | + |
Dysplasia | 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + +|
Dysplasia | 1 1 1 1 1 3 3 1 2 1 3 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Inflammation, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 1 |
Hypertrophy | 1 2 2|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3|
| 4| 3| 5| 0| 4| 1| 1| 1| 5| 0| 1| 0| 1| 6| 0| 1| 6| 1| 5| 6| 4| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 3 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + M + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 1 3 1 1 2 3 1 3 1 3 2 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 2 1 2 1 2 2 1 3|
Dilatation | |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 4 1 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + M + + + + + + M + + + + M|
Atrophy | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3|
| 4| 3| 5| 0| 4| 1| 1| 1| 5| 0| 1| 0| 1| 6| 0| 1| 6| 1| 5| 6| 4| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 2 2 3 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + M + + + +|
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + M + M + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Subcutaneous Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 2 |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 |
Olfactory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Bacterium | 4 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 6| 6| 3| 3| 3| 3| 3| 6| 8| 3| 3| 3| 6| 3| 3| 3| 3| 3| 6| 3|
| 4| 3| 5| 0| 4| 1| 1| 1| 5| 0| 1| 0| 1| 6| 0| 1| 6| 1| 5| 6| 4| 1| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
250 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X X |
Inflammation, Chronic Active | 4 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 1 3 1 1 1 3 1 2 1 1 1 1 1 1 1|
Pelvis, Inflammation, Chronic | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Bacterium | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | |
Transitional Epithelium, Bacterium | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 5| 5| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 7| 6| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| | |
| 8| 6| 4| 0| 4| 3| 8| 5| 1| 4| 0| 6| 0| 4| 4| 5| 1| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 56 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 61 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Fatty Change | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Hemorrhage | 3 | 1 3.0|
Mixed Cell Focus | | 2 |
Bile Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 61 |
Inflammation, Chronic | | 2 1.0|
Arteriole, Inflammation, Chronic | | 1 2.0|
Arteriole, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 58 |
Hyperplasia, Squamous | 3 3 2 2 2 3 3 2 3 2 | 38 2.3|
Ulcer | 2 2 2 1 | 14 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 57 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Tongue | | 3 |
Dysplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + | 43 |
Dysplasia | 2 2 1 1 1 1 1 1 2 1 2 1 | 42 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 61 |
Cardiomyopathy | | 6 1.5|
Inflammation, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 5| 5| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 7| 6| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| | |
| 8| 6| 4| 0| 4| 3| 8| 5| 1| 4| 0| 6| 0| 4| 4| 5| 1| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 61 |
Hyperplasia | 2 | 5 1.8|
Hypertrophy | 1 | 7 1.4|
Capsule, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 1 2 1 | 51 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 61 |
Hyperplasia | 1 1 2 1 1 1 2 1 | 17 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M M + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M | 59 |
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 61 |
Inflammation, Chronic | | 1 1.0|
Follicular Cell, Hyperplasia | 2 1 1 2 2 3 4 3 2 2 2 3 | 45 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Granuloma Sperm | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Atrophy | 2 2 2 1 1 2 2 1 | 25 1.8|
Dilatation | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 2 4 1 2 1 2 1 1 2 | 35 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 62 |
Abscess | | 1 2.0|
Inflammation, Acute | 2 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 62 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Granuloma Sperm | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 60 |
Myelofibrosis | | 1 1.0|
Proliferation | 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 5| 5| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 7| 6| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| | |
| 8| 6| 4| 0| 4| 3| 8| 5| 1| 4| 0| 6| 0| 4| 4| 5| 1| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 54 |
Atrophy | | 3 2.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 57 |
Atrophy | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 61 |
Lymphoid Follicle, Atrophy | 3 | 2 2.5|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 2 1 | 11 1.6|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 1 2 3 2 | 17 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + | 55 |
Cyst | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + M | 54 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 61 |
Abscess | | 1 4.0|
Subcutaneous Tissue, Foreign Body | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + | 61 |
Degeneration | 1 1 | 8 1.1|
Infiltration Cellular, Lymphocyte | | 2 1.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 61 |
Mineralization | 1 1 1 1 1 1 1 1 1 2 | 28 1.1|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + | 61 |
Degeneration | | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 61 |
Hemorrhage | 1 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 5| 5| 5| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 7| 6| 0| 3| 6| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| | |
| 8| 6| 4| 0| 4| 3| 8| 5| 1| 4| 0| 6| 0| 4| 4| 5| 1| 1| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
250 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 61 |
Inflammation, Chronic | 1 2 1 1 1 | 14 1.1|
Olfactory Epithelium, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 61 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 61 |
Bacterium | 4 | 2 4.0|
Cyst | X | 3 |
Inflammation, Chronic Active | 4 | 3 4.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 1 | 43 1.2|
Pelvis, Inflammation, Chronic | 2 2 | 5 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
Renal Tubule, Bacterium | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 62 |
Dilatation | | 2 4.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | 2 2 | 4 2.0|
Transitional Epithelium, Bacterium | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 4| 7| 7| 7| 2| 0| 7| 4| 5| 7| 6| 7| 4| 2| 7| 7| 4| 4| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 0| 6| 3| 3| 3| 5| 8| 3| 6| 8| 3| 2| 3| 6| 7| 3| 3| 6| 5| 3|
| 6| 4| 8| 1| 4| 6| 1| 5| 0| 4| 1| 6| 4| 1| 7| 4| 5| 6| 1| 5| 5| 5| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Subacute | 2 |
Perforation | |
__________________________________________________________________________|
Gallbladder | + + + + + A + + + A + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + A + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + A + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + A + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + A + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + A + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + A + + M + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + +|
Basophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | X |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + A + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + A + + + + + + + + + + +|
Cyst | |
Hyperplasia, Squamous | 2 3 2 4 2|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + A + + + + + + + + + + +|
Edema | |
Erosion | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Abscess | 4 |
Dysplasia | 1 2 1 2 1 1 4 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 4| 7| 7| 7| 2| 0| 7| 4| 5| 7| 6| 7| 4| 2| 7| 7| 4| 4| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 0| 6| 3| 3| 3| 5| 8| 3| 6| 8| 3| 2| 3| 6| 7| 3| 3| 6| 5| 3|
| 6| 4| 8| 1| 4| 6| 1| 5| 0| 4| 1| 6| 4| 1| 7| 4| 5| 6| 1| 5| 5| 5| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia | |
Hypertrophy | 1 1 |
Inflammation, Chronic | 1 |
Capsule, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + A + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + A + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + M + + A + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 1 4 2 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 1 3 1 2 3 1 |
Hyperplasia | |
Inflammation, Chronic | 2 1 2 1 1 4 1 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Concretion | 2 |
Congestion | |
Hyperplasia | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 4| 7| 7| 7| 2| 0| 7| 4| 5| 7| 6| 7| 4| 2| 7| 7| 4| 4| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 0| 6| 3| 3| 3| 5| 8| 3| 6| 8| 3| 2| 3| 6| 7| 3| 3| 6| 5| 3|
| 6| 4| 8| 1| 4| 6| 1| 5| 0| 4| 1| 6| 4| 1| 7| 4| 5| 6| 1| 5| 5| 5| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2 1 1 X |
Myeloid Cell, Proliferation | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + +|
Atrophy | |
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + A + + + A M + + + M + + + + + +|
Angiectasis | |
Atrophy | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | 2 2 3 |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 2 |
Red Pulp, Atrophy | |
Red Pulp, Hematopoietic Cell | |
Proliferation | 2 3 2 1 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + A + M + + + + + + + + M|
Cyst | X |
Ectopic Parathyroid Gland | |
Inflammation, Chronic | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + M + + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + M + + + + +|
Mineralization | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 1 1|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 0| 4| 7| 7| 7| 2| 0| 7| 4| 5| 7| 6| 7| 4| 2| 7| 7| 4| 4| 7|
DAY ON TEST | 3| 3| 1| 3| 3| 0| 6| 3| 3| 3| 5| 8| 3| 6| 8| 3| 2| 3| 6| 7| 3| 3| 6| 5| 3|
| 6| 4| 8| 1| 4| 6| 1| 5| 0| 4| 1| 6| 4| 1| 7| 4| 5| 6| 1| 5| 5| 5| 1| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Glands, Hyperplasia, Glandular | |
Nasolacrimal Duct, Hyperplasia | 3 2 |
Olfactory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cyst | X |
Hydronephrosis | |
Inflammation, Chronic Active | 3 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 1 2 1 2 1 1 1 2 2 3 3 2 1 1|
Pelvis, Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Chronic | 2 3 1 |
Transitional Epithelium, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 5| 7| 5| 4| 6| 7| 0| 0| 7| 2| 7| 2| 5| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 3| 0| 3| 3| 3| 6| 3| 0| 6| 0| 3| 8| 9| 3| 6| 3| 5| 5| 3| 3| 4| 3| 3| 3|
| 1| 1| 6| 6| 4| 4| 1| 0| 3| 1| 0| 0| 5| 0| 6| 7| 5| 6| 4| 4| 6| 4| 0| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Subacute | |
Perforation | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Squamous | 2 2 3 2 3 2 2 3 3|
Ulcer | 2 2 2 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + |
Abscess | 2 |
Dysplasia | 2 1 2 1 2 4 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1|
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 5| 7| 5| 4| 6| 7| 0| 0| 7| 2| 7| 2| 5| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 3| 0| 3| 3| 3| 6| 3| 0| 6| 0| 3| 8| 9| 3| 6| 3| 5| 5| 3| 3| 4| 3| 3| 3|
| 1| 1| 6| 6| 4| 4| 1| 0| 3| 1| 0| 0| 5| 0| 6| 7| 5| 6| 4| 4| 6| 4| 0| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M|
Focal Cellular Change | 1 |
Hyperplasia | |
Hypertrophy | 1 |
Inflammation, Chronic | |
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + + + + + M + + M + + M M +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + M +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1|
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 3 2 1 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 1 2 |
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 2 2 1 3 2 1 2|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Concretion | 2 2 2 2|
Congestion | 3 |
Hyperplasia | 1 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 5| 7| 5| 4| 6| 7| 0| 0| 7| 2| 7| 2| 5| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 3| 0| 3| 3| 3| 6| 3| 0| 6| 0| 3| 8| 9| 3| 6| 3| 5| 5| 3| 3| 4| 3| 3| 3|
| 1| 1| 6| 6| 4| 4| 1| 0| 3| 1| 0| 0| 5| 0| 6| 7| 5| 6| 4| 4| 6| 4| 0| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | X 2 |
Myeloid Cell, Proliferation | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + M + + + + + + + + M +|
Atrophy | 3 |
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia, | |
Lymphoid | 1 2 2|
Red Pulp, Atrophy | 1 |
Red Pulp, Hematopoietic Cell | |
Proliferation | 1 3 2 3 1 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | X |
Ectopic Parathyroid Gland | |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + M + + + + + + + M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 1 |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
_____________________________________________________________________________________________________________________
| 6| 7| 2| 7| 7| 7| 5| 7| 5| 4| 6| 7| 0| 0| 7| 2| 7| 2| 5| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 3| 0| 3| 3| 3| 6| 3| 0| 6| 0| 3| 8| 9| 3| 6| 3| 5| 5| 3| 3| 4| 3| 3| 3|
| 1| 1| 6| 6| 4| 4| 1| 0| 3| 1| 0| 0| 5| 0| 6| 7| 5| 6| 4| 4| 6| 4| 0| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
500 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 1 1 1 1|
Glands, Hyperplasia, Glandular | 2 |
Nasolacrimal Duct, Hyperplasia | |
Olfactory Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 4 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cyst | 3 X X|
Hydronephrosis | |
Inflammation, Chronic Active | 2 4 4 3 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 3 1 2 2 1 3 3 1 1 1 1 3 2 2 3 2 3|
Pelvis, Inflammation, Chronic | 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 |
Inflammation, Chronic | 2 2 3 3 2 |
Transitional Epithelium, Hyperplasia | 1 2 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 5| 1| 7| 5| 7| 4| 4| 7| 6| 4| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 6| 6| 6| 3| 6| 9| 3| 9| 3| 5| 6| 3| 2| 6| 6| 3| 3| 5| 3| | |
| 0| 1| 1| 1| 4| 3| 1| 4| 9| 5| 4| 1| 6| 9| 1| 8| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + A + + + + | 59 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Subacute | | 1 2.0|
Perforation | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + M + M + + + + + A A + + + + | 53 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A A + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A A + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A A + + A + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A A + + A + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A A + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A A + + A + | 54 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + A A + + + + | 57 |
Basophilic Focus | | 1 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + | 57 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A A + + + + | 56 |
Cyst | 1 | 1 1.0|
Hyperplasia, Squamous | 2 3 2 2 | 18 2.4|
Ulcer | 1 1 | 8 1.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A A + + + + | 56 |
Edema | | 1 2.0|
Erosion | 2 | 1 2.0|
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + + + + | 23 |
Abscess | | 2 3.0|
Dysplasia | 2 1 1 2 2 | 23 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 5| 1| 7| 5| 7| 4| 4| 7| 6| 4| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 6| 6| 6| 3| 6| 9| 3| 9| 3| 5| 6| 3| 2| 6| 6| 3| 3| 5| 3| | |
| 0| 1| 1| 1| 4| 3| 1| 4| 9| 5| 4| 1| 6| 9| 1| 8| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 6 1.2|
Inflammation, Chronic | | 3 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 59 |
Focal Cellular Change | | 1 1.0|
Hyperplasia | 2 | 1 2.0|
Hypertrophy | | 3 1.0|
Inflammation, Chronic | | 1 1.0|
Capsule, Hyperplasia | 2 1 2 2 1 1 2 1 1 1 | 45 1.2|
Capsule, Inflammation, Chronic Active| 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A A + + + + | 55 |
Hyperplasia | 1 | 6 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + A + + + + | 49 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + M + + + + | 53 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 3 1 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + | 57 |
Follicular Cell, Hyperplasia | 1 2 3 1 2 2 | 27 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + A + + + + | 69 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + A + + + + | 59 |
Atrophy | 3 4 3 | 17 2.2|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 1 1 1 2 1 1 2 | 23 1.6|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Concretion | 2 2 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 5| 1| 7| 5| 7| 4| 4| 7| 6| 4| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 6| 6| 6| 3| 6| 9| 3| 9| 3| 5| 6| 3| 2| 6| 6| 3| 3| 5| 3| | |
| 0| 1| 1| 1| 4| 3| 1| 4| 9| 5| 4| 1| 6| 9| 1| 8| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
Hyperplasia | | 1 1.0|
Inflammation, Chronic | 2 | 3 2.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + | 57 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + A + + + + | 69 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + | 58 |
Proliferation | | 6 1.5|
Myeloid Cell, Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + A + M + + | 53 |
Atrophy | | 1 3.0|
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + | 54 |
Angiectasis | 2 2 | 2 2.0|
Atrophy | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + M + + + + | 59 |
Lymphoid Follicle, Atrophy | 2 3 1 2 | 7 2.1|
Lymphoid Follicle, Hyperplasia, | | |
Lymphoid | 1 | 5 1.6|
Red Pulp, Atrophy | | 1 1.0|
Red Pulp, Hematopoietic Cell | | |
Proliferation | 2 3 | 13 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + A + + + + | 52 |
Cyst | X X | 4 |
Ectopic Parathyroid Gland | X | 1 |
Inflammation, Chronic | | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + M + + M M + M | 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 61 |
Subcutaneous Tissue, Abscess | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 5| 1| 7| 5| 7| 4| 4| 7| 6| 4| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 6| 6| 6| 3| 6| 9| 3| 9| 3| 5| 6| 3| 2| 6| 6| 3| 3| 5| 3| | |
| 0| 1| 1| 1| 4| 3| 1| 4| 9| 5| 4| 1| 6| 9| 1| 8| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 60 |
Degeneration | 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 59 |
Mineralization | 1 1 1 1 1 2 | 23 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + A + + + + | 59 |
Congestion | | 1 3.0|
Hemorrhage | 1 | 6 1.2|
Inflammation, Chronic | | 3 1.7|
Leukocytosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + | 58 |
Inflammation, Chronic | 1 2 1 1 1 1 | 13 1.3|
Glands, Hyperplasia, Glandular | | 1 2.0|
Nasolacrimal Duct, Hyperplasia | 2 | 3 2.3|
Olfactory Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 60 |
Bacterium | 2 | 1 2.0|
Cyst | X X X | 7 3.0|
Hydronephrosis | 3 | 1 3.0|
Inflammation, Chronic Active | | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05214-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 10/21/96
Route: GAVAGE Time: 15:13:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 5| 1| 7| 5| 7| 4| 4| 7| 6| 4| 4| 7| 7| 4| 7| | |
DAY ON TEST | 3| 6| 6| 6| 3| 6| 9| 3| 9| 3| 5| 6| 3| 2| 6| 6| 3| 3| 5| 3| | |
| 0| 1| 1| 1| 4| 3| 1| 4| 9| 5| 4| 1| 6| 9| 1| 8| 0| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
500 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | 1 1 2 1 1 1 1 1 | 32 1.0|
Nephropathy | 2 1 4 2 2 1 1 3 2 | 42 1.8|
Pelvis, Inflammation, Chronic | 1 4 | 12 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + | 58 |
Dilatation | 3 3 4 4 | 7 2.9|
Inflammation, Chronic | 2 | 9 2.2|
Transitional Epithelium, Hyperplasia | | 8 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
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