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https://ntp.niehs.nih.gov/go/4711

TDMS Study 05214-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL


NTP Experiment-Test: 05214-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: GAVAGE                                                                                                     Time: 12:11:42




       Facility:  TSI Mason Research

       Chemical CAS #:  1972-08-3

       Lock Date:  06/17/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  9            9            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18            9            9           10                                     
    Natural Death                                      8            2            6            5                                     
    Dosing Accident                                    2                         3            1                                     
    Accidently Killed                                                                         2                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        1                                     
    Natural Death                                                   1                         1                                     
    Terminal Sacrifice                                23           39           33           30                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Intestine Large, Colon                             (58)         (59)         (60)         (57)                                   
      Dilatation                                       1 (2%)                                                                       
   Intestine Large, Rectum                            (55)         (59)         (59)         (57)                                   
      Dilatation                                       1 (2%)                                                                       
   Intestine Large, Cecum                             (54)         (59)         (58)         (57)                                   
      Dilatation                                                    1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Lymphoid Tissue, Hyperplasia, Lymphoid                                                  1 (2%)                                
   Intestine Small, Duodenum                          (59)         (60)         (59)         (57)                                   
      Ectopic Tissue                                                                          1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Angiectasis                                                   1 (2%)       1 (2%)       1 (2%)                                
      Basophilic Focus                                52 (87%)     52 (87%)     51 (85%)     51 (85%)                               
      Clear Cell Focus                                19 (32%)     21 (35%)     22 (37%)     15 (25%)                               
      Congestion                                                    2 (3%)                                                          
      Cyst                                             1 (2%)       1 (2%)                                                          
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                               3 (5%)       7 (12%)      4 (7%)       9 (15%)                               
      Fatty Change                                     7 (12%)                   1 (2%)       1 (2%)                                
      Fatty Change, Focal                                                                     2 (3%)                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                      14 (23%)     13 (22%)      9 (15%)      9 (15%)                               
      Hepatodiaphragmatic Nodule, Multiple                                       1 (2%)                                             
      Hyperplasia                                      2 (3%)       6 (10%)      7 (12%)      5 (8%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mixed Cell Focus                                 3 (5%)       5 (8%)       2 (3%)       7 (12%)                               
      Necrosis                                         2 (3%)                                 1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Serosa, Fibrosis                                                           1 (2%)                                             
   Mesentery                                          (6)          (5)          (2)          (1)                                    
      Fat, Fibrosis                                                                           1 (100%)                              
      Fat, Hemorrhage                                               1 (20%)                   1 (100%)                              
      Fat, Necrosis                                    5 (83%)      4 (80%)      2 (100%)                                           
      Fat, Pigmentation                                1 (17%)                                                                      
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Cyst                                                                       1 (2%)                                             
      Ectopic Tissue                                                             2 (3%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Metaplasia                                                    1 (2%)                    2 (3%)                                
      Acinus, Atrophy                                 27 (45%)     27 (45%)     23 (38%)     31 (53%)                               
      Acinus, Hyperplasia                              1 (2%)       1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Degeneration                                     1 (2%)                                                                       
      Focal Cellular Change                                         3 (5%)       4 (7%)                                             
      Duct, Inflammation, Acute                                                               1 (2%)                                
      Duct, Metaplasia, Squamous                       5 (8%)       1 (2%)       2 (3%)       3 (5%)                                
      Duct, Mineralization                                                                    1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Dilatation                                                    1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                   2 (3%)                    2 (3%)       1 (2%)                                
      Hyperplasia, Basal Cell                          6 (10%)      4 (7%)       6 (10%)      3 (5%)                                
      Hyperplasia, Cystic                                                                     1 (2%)                                
      Hyperplasia, Focal, Squamous                                  1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Perforation                                                                1 (2%)                                             
      Ulcer                                            4 (7%)       2 (3%)       1 (2%)       3 (5%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (58)                                   
      Erosion                                          1 (2%)       1 (2%)       1 (2%)       4 (7%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Ulcer                                                         1 (2%)       1 (2%)       1 (2%)                                
   Tooth                                              (1)                                                                           
      Foreign Body                                     1 (100%)                                                                     
      Inflammation, Chronic Active                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Cardiomyopathy                                  48 (80%)     49 (82%)     49 (82%)     50 (83%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Clear Cell Focus                                                           3 (5%)                                             
      Congestion                                                                              1 (2%)                                
      Focal Cellular Change                            2 (3%)       1 (2%)                                                          
      Hyperplasia                                      2 (3%)       5 (8%)       4 (7%)       2 (3%)                                
      Hypertrophy                                                                1 (2%)                                             
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      3 (5%)       3 (5%)       3 (5%)       2 (3%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (59)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (57)         (56)         (57)         (52)                                   
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Angiectasis                       4 (7%)       5 (8%)       7 (12%)      5 (8%)                                
      Pars Distalis, Cyst                             22 (37%)     30 (50%)     29 (48%)     24 (40%)                               
      Pars Distalis, Hyperplasia                      25 (42%)     18 (30%)     12 (20%)     22 (37%)                               
      Pars Intermedia, Atypia Cellular                 1 (2%)                                                                       
      Pars Intermedia, Cyst                                         1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Cyst                                                          1 (2%)                    1 (2%)                                
      C-Cell, Hyperplasia                             17 (28%)     19 (32%)     14 (23%)     12 (20%)                               
      Follicular Cell, Hyperplasia                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Mediastinum, Granuloma                                        1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (57)         (55)         (60)         (59)                                   
      Abscess                                          1 (2%)                                                                       
      Cyst                                                          2 (4%)       5 (8%)       1 (2%)                                
      Dilatation                                       2 (4%)                    1 (2%)       1 (2%)                                
      Hyperplasia                                                   3 (5%)       2 (3%)       1 (2%)                                
      Inflammation, Acute                                           1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                                            2 (3%)                                
   Ovary                                              (60)         (59)         (59)         (60)                                   
      Cyst                                             6 (10%)     11 (19%)      5 (8%)       7 (12%)                               
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Dilatation                                       4 (7%)       5 (8%)       7 (12%)      2 (3%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Glandular                                                     1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hyperplasia, Re Cell                                                       1 (2%)       1 (2%)                                
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (6)          (6)          (10)         (7)                                    
      Lumbar, Necrosis                                                                        1 (14%)                               
      Mediastinal, Angiectasis                         2 (33%)      1 (17%)      3 (30%)                                            
      Mediastinal, Ectasia                                          1 (17%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (14%)                               
      Mediastinal, Pigmentation                        1 (17%)      1 (17%)      3 (30%)                                            
      Pancreatic, Ectasia                                                        1 (10%)                                            
      Pancreatic, Infiltration Cellular, Histiocyte                              1 (10%)                                            
   Lymph Node, Mandibular                             (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Infiltration Cellular, Plasma Cell                            2 (3%)       3 (5%)                                             
      Necrosis                                                                                1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Depletion Lymphoid                               1 (2%)                                 1 (2%)                                
      Fibrosis                                         1 (2%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 3 (5%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                     1 (2%)                    1 (2%)                                             
      Capsule, Fibrosis                                                          1 (2%)                                             
   Thymus                                             (55)         (56)         (59)         (57)                                   
      Cyst                                                          1 (2%)                                                          
      Ectopic Thyroid                                                            1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (58)         (59)         (56)                                   
      Galactocele                                                   4 (7%)       7 (12%)      5 (9%)                                
      Hyperplasia                                                                1 (2%)                                             
   Skin                                               (60)         (60)         (60)         (60)                                   
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                       1 (2%)                                                                       
      Cyst Epithelial Inclusion                        2 (3%)                    1 (2%)       1 (2%)                                
      Erosion                                                       1 (2%)                                                          
      Hyperkeratosis                                   2 (3%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ulcer                                                                      1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Developmental Malformation                       1 (2%)                                                                       
      Hyperostosis                                     1 (2%)                                                                       
   Skeletal Muscle                                    (60)         (60)         (59)         (60)                                   
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Mineralization                                                                          2 (3%)                                
      Cerebrum, Neuron, Necrosis                                    1 (2%)                                                          
      Hippocampus, Neuron, Necrosis                                 1 (2%)                                                          
   Spinal Cord                                        (60)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Edema                                            3 (5%)       1 (2%)       4 (7%)       3 (5%)                                
      Foreign Body                                    15 (25%)     13 (22%)     19 (32%)     12 (20%)                               
      Hemorrhage                                       1 (2%)       3 (5%)       4 (7%)       2 (3%)                                
      Infiltration Cellular, Histiocyte                7 (12%)      2 (3%)       4 (7%)       7 (12%)                               
      Inflammation, Chronic Active                    28 (47%)     51 (85%)     48 (80%)     46 (77%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                 2 (3%)                                
      Mediastinum, Inflammation, Acute                                           1 (2%)                                             
      Pleura, Bacterium                                1 (2%)                                                                       
      Pleura, Inflammation, Acute                      1 (2%)                                                                       
   Nose                                               (60)         (60)         (60)         (60)                                   
      Bacterium                                        2 (3%)                    1 (2%)                                             
      Foreign Body                                     1 (2%)       1 (2%)       5 (8%)                                             
      Fungus                                           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Acute                             13 (22%)      6 (10%)      8 (13%)      7 (12%)                               
      Respiratory Epithelium, Metaplasia                                                      1 (2%)                                
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (3)          (3)          (1)                                    
      Phthisis Bulbi                                                1 (33%)      1 (33%)                                            
      Synechia                                         1 (33%)                   2 (67%)                                            
      Lens, Cataract                                   3 (100%)     2 (67%)      1 (33%)                                            
      Retina, Atrophy                                  1 (33%)      1 (33%)      1 (33%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Nephropathy                                     43 (72%)     41 (68%)     42 (70%)     39 (65%)                               
      Pigmentation                                                               1 (2%)                                             
      Cortex, Mineralization                          25 (42%)     18 (30%)     22 (37%)     20 (33%)                               
      Renal Tubule, Degeneration, Hyaline              1 (2%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (60)         (59)                                   
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          80           60           70           70                                     
  Scheduled Sacrifice                                 10            9            9            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19            8           11           10                                     
    Natural Death                                     10            8            6           10                                     
    Dosing Accident                                    1                         2                                                  
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                                             1                                     
    Terminal Sacrifice                                22           35           33           30                                     
  Special Study                                       18                         9            9                                     
  Animals Examined Microscopically                    62           60           61           61                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (62)         (60)         (61)         (61)                                   
      Abscess                                                                    1 (2%)                                             
      Perforation                                      1 (2%)                    2 (3%)                                             
   Intestine Large, Colon                             (62)         (58)         (59)         (58)                                   
      Bacterium                                                     1 (2%)                                                          
      Dilatation                                                                              1 (2%)                                
   Intestine Large, Cecum                             (55)         (57)         (59)         (56)                                   
      Bacterium                                                     1 (2%)                                                          
      Dilatation                                       2 (4%)                    1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (58)         (58)         (60)         (55)                                   
      Dilatation                                       1 (2%)                                                                       
   Liver                                              (62)         (60)         (61)         (61)                                   
      Bacterium                                                     1 (2%)                                                          
      Basophilic Focus                                23 (37%)     20 (33%)     27 (44%)     22 (36%)                               
      Clear Cell Focus                                33 (53%)     34 (57%)     37 (61%)     36 (59%)                               
      Congestion                                                    1 (2%)                                                          
      Cyst                                                                       1 (2%)       1 (2%)                                
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                               7 (11%)      8 (13%)      2 (3%)       5 (8%)                                
      Fatty Change                                     1 (2%)                                                                       
      Fatty Change, Diffuse                                         1 (2%)       1 (2%)                                             
      Fatty Change, Focal                             14 (23%)     17 (28%)     18 (30%)     13 (21%)                               
      Hepatodiaphragmatic Nodule                       3 (5%)       6 (10%)      9 (15%)      2 (3%)                                
      Hyperplasia                                                   1 (2%)                    1 (2%)                                
      Mixed Cell Focus                                 1 (2%)       2 (3%)       5 (8%)       3 (5%)                                
      Necrosis                                         1 (2%)       2 (3%)       1 (2%)                                             
      Vein, Dilatation                                              2 (3%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (6)          (5)          (3)          (4)                                    
      Artery, Inflammation, Chronic Active                                                    1 (25%)                               
      Fat, Fibrosis                                                 1 (20%)      1 (33%)                                            
      Fat, Hemorrhage                                               1 (20%)                                                         
      Fat, Inflammation, Chronic Active                1 (17%)                   1 (33%)      1 (25%)                               
      Fat, Mineralization                                                        1 (33%)                                            
      Fat, Necrosis                                    4 (67%)      4 (80%)      1 (33%)                                            
   Pancreas                                           (62)         (60)         (61)         (61)                                   
      Bacterium                                                     1 (2%)                                                          
      Metaplasia                                                                 1 (2%)       1 (2%)                                
      Acinus, Atrophy                                 30 (48%)     31 (52%)     30 (49%)     30 (49%)                               
      Acinus, Hyperplasia                             21 (34%)     10 (17%)      3 (5%)       3 (5%)                                
      Artery, Hyperplasia                                                        1 (2%)                                             
      Artery, Inflammation, Chronic Active             2 (3%)       1 (2%)                    1 (2%)                                
      Artery, Pigmentation                                          1 (2%)                                                          
   Salivary Glands                                    (62)         (60)         (61)         (61)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Acinus, Atrophy                                               1 (2%)                                                          
      Duct, Metaplasia, Squamous                       9 (15%)      6 (10%)      4 (7%)       7 (11%)                               
   Stomach, Forestomach                               (62)         (59)         (61)         (61)                                   
      Erosion                                          1 (2%)                    1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                    1 (2%)                                             
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Hyperplasia, Cystic                                                        1 (2%)                                             
      Hyperplasia, Diffuse, Squamous                  11 (18%)      3 (5%)       6 (10%)      1 (2%)                                
      Hyperplasia, Focal, Squamous                     1 (2%)                    2 (3%)       1 (2%)                                
      Ulcer                                            9 (15%)      1 (2%)       7 (11%)                                            
   Stomach, Glandular                                 (62)         (60)         (61)         (58)                                   
      Bacterium                                                     1 (2%)                                                          
      Erosion                                         10 (16%)      7 (12%)      4 (7%)       4 (7%)                                
      Hyperplasia                                      1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                   2 (3%)                                                                       
      Ulcer                                            3 (5%)                                 2 (3%)                                
   Tooth                                                                        (1)                                                 
      Abscess                                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (62)         (60)         (61)         (61)                                   
      Bacterium                                        1 (2%)       1 (2%)                                                          
      Cardiomyopathy                                  60 (97%)     55 (92%)     56 (92%)     56 (92%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Mineralization                                   2 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (62)         (60)         (61)         (61)                                   
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy                                                                             1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
   Adrenal Medulla                                    (62)         (60)         (61)         (61)                                   
      Bacterium                                                     1 (2%)                                                          
      Hyperplasia                                     21 (34%)     14 (23%)     17 (28%)     15 (25%)                               
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (62)         (60)         (61)         (61)                                   
      Hyperplasia                                      5 (8%)       1 (2%)       1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (58)         (55)         (53)         (56)                                   
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (62)         (60)         (60)         (61)                                   
      Pars Distalis, Angiectasis                                    4 (7%)       1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                              3 (5%)       7 (12%)     12 (20%)      9 (15%)                               
      Pars Distalis, Hemorrhage                        1 (2%)                                 1 (2%)                                
      Pars Distalis, Hyperplasia                      17 (27%)     22 (37%)     21 (35%)     22 (36%)                               
      Pars Intermedia, Cyst                            2 (3%)       1 (2%)                                                          
   Thyroid Gland                                      (62)         (59)         (60)         (59)                                   
      Congestion                                                                              1 (2%)                                
      C-Cell, Hyperplasia                             11 (18%)      9 (15%)      9 (15%)      8 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (62)         (60)         (61)         (61)                                   
      Atypia Cellular                                                            1 (2%)                                             
      Degeneration                                                               1 (2%)                                             
   Preputial Gland                                    (62)         (60)         (61)         (59)                                   
      Dilatation                                                                 3 (5%)       1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Prostate                                           (62)         (60)         (61)         (61)                                   
      Abscess                                                                    1 (2%)       1 (2%)                                
      Concretion                                                                              1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Seminal Vesicle                                    (62)         (60)         (61)         (61)                                   
      Atrophy                                          5 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Concretion                                       2 (3%)       1 (2%)                                                          
   Testes                                             (62)         (60)         (61)         (61)                                   
      Inflammation                                     2 (3%)                    1 (2%)       1 (2%)                                
      Interstitial Cell, Hyperplasia                  13 (21%)     28 (47%)     25 (41%)     30 (49%)                               
      Seminiferous Tubule, Atrophy                     7 (11%)      5 (8%)       9 (15%)      5 (8%)                                
      Seminiferous Tubule, Mineralization                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (62)         (60)         (61)         (61)                                   
      Degeneration                                                               1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
   Lymph Node                                         (14)         (5)          (5)          (3)                                    
      Mediastinal, Angiectasis                         1 (7%)       1 (20%)                   1 (33%)                               
      Mediastinal, Ectasia                             1 (7%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (7%)                                                                       
      Mediastinal, Pigmentation                        1 (7%)                                 1 (33%)                               
      Pancreatic, Degeneration                                                   1 (20%)                                            
      Pancreatic, Hyperplasia, Lymphoid                1 (7%)                                                                       
   Lymph Node, Mandibular                             (62)         (59)         (61)         (61)                                   
      Ectasia                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                                   2 (3%)                                                          
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
   Lymph Node, Mesenteric                             (62)         (60)         (61)         (61)                                   
      Congestion                                                                              1 (2%)                                
      Infiltration Cellular                            1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Spleen                                             (62)         (60)         (61)         (60)                                   
      Angiectasis                                                                             1 (2%)                                
      Bacterium                                                     1 (2%)                                                          
      Congestion                                       1 (2%)                                 1 (2%)                                
      Depletion Lymphoid                               1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                         2 (3%)                    4 (7%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    2 (3%)                                             
      Necrosis                                                      2 (3%)       1 (2%)                                             
      Pigmentation                                                  3 (5%)       2 (3%)       2 (3%)                                
      Capsule, Necrosis                                                                       1 (2%)                                
   Thymus                                             (59)         (57)         (55)         (57)                                   
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (43)         (52)         (52)         (46)                                   
      Fibrosis                                                                                2 (4%)                                
      Galactocele                                      3 (7%)                    2 (4%)       1 (2%)                                
      Hemorrhage                                                                              2 (4%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (2%)                                
   Skin                                               (62)         (60)         (61)         (61)                                   
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                                                              1 (2%)                                
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (62)         (60)         (61)         (61)                                   
      Fracture                                         1 (2%)                    1 (2%)                                             
      Hyperostosis                                                  1 (2%)                                                          
   Skeletal Muscle                                    (62)         (60)         (60)         (61)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (62)         (59)         (61)         (61)                                   
      Congestion                                                                              1 (2%)                                
      Gliosis, Focal                                                                          1 (2%)                                
      Hemorrhage                                       2 (3%)                                 1 (2%)                                
      Mineralization                                   1 (2%)                                 1 (2%)                                
      Cerebellum, Neuron, Necrosis                                               1 (2%)       1 (2%)                                
      Hippocampus, Neuron, Necrosis                    4 (6%)       1 (2%)                                                          
   Spinal Cord                                        (62)         (59)         (58)         (59)                                   
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (62)         (60)         (61)         (61)                                   
      Bacterium                                        1 (2%)       1 (2%)       1 (2%)                                             
      Congestion                                       1 (2%)       2 (3%)                    1 (2%)                                
      Edema                                            1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Fibrosis                                                      1 (2%)                    1 (2%)                                
      Foreign Body                                     8 (13%)     26 (43%)     26 (43%)     15 (25%)                               
      Granuloma                                                                               1 (2%)                                
      Hemorrhage                                       2 (3%)       2 (3%)       1 (2%)       7 (11%)                               
      Infiltration Cellular, Histiocyte                4 (6%)       5 (8%)       5 (8%)       8 (13%)                               
      Inflammation, Acute                                                        3 (5%)       1 (2%)                                
      Inflammation, Chronic Active                    40 (65%)     44 (73%)     43 (70%)     39 (64%)                               
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (3%)       4 (7%)       2 (3%)                                
      Mediastinum, Bacterium                                                                  1 (2%)                                
      Mediastinum, Inflammation, Chronic Active                                               1 (2%)                                
      Pleura, Inflammation, Acute                                                1 (2%)                                             
   Nose                                               (62)         (60)         (61)         (61)                                   
      Bacterium                                                     1 (2%)                                                          
      Cyst                                                                                    1 (2%)                                
      Foreign Body                                     1 (2%)       3 (5%)       3 (5%)       5 (8%)                                
      Fungus                                          14 (23%)      4 (7%)       3 (5%)       6 (10%)                               
      Inflammation, Acute                             28 (45%)     15 (25%)     15 (25%)     15 (25%)                               
      Respiratory Epithelium, Metaplasia, Squamous     6 (10%)      2 (3%)       2 (3%)                                             
   Trachea                                            (62)         (60)         (61)         (61)                                   
      Abscess                                                                    1 (2%)                                             
      Erosion                                                                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Perforation                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (18)         (22)         (17)         (21)                                   
      Hemorrhage                                                                 1 (6%)                                             
      Inflammation, Chronic Active                                               1 (6%)                                             
      Lens, Cataract                                  18 (100%)    21 (95%)     16 (94%)     20 (95%)                               
      Retina, Atrophy                                               2 (9%)                    1 (5%)                                
   Harderian Gland                                                                           (1)                                    
      Hyperplasia                                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05214-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (62)         (60)         (61)         (61)                                   
      Bacterium                                                     1 (2%)                                                          
      Cyst                                             6 (10%)                   1 (2%)                                             
      Degeneration                                                                            1 (2%)                                
      Hydronephrosis                                                                          1 (2%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Nephropathy                                     61 (98%)     57 (95%)     56 (92%)     56 (92%)                               
      Cortex, Mineralization                           4 (6%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Degeneration, Hyaline                                                     1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (61)         (60)         (61)         (61)                                   
      Calculus Gross Observation                       2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Calculus Micro Observation Only                  2 (3%)       1 (2%)       3 (5%)       2 (3%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------