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TDMS Study 05214-01 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL


NTP Experiment-Test: 05214-01                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 03/18/94
Route: GAVAGE                                                                                                     Time: 18:28:14


                                                       2 YEAR CORE STUDY


       Facility:  TSI Mason Research

       Chemical CAS #:  1972-08-3

       Lock Date:  06/17/92

       Cage Range:  All

       Reasons For Removal:    25008 Accident                          25022 Accidently Killed
                               25018 Dosing Accident                   25003 Moribund
                               25019 Moribund Sacrifice                25020 Natural Death
                               25006 Terminal Sacrifice                25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    0       MG/KG
                               Include 004    12.5    MG/KG
                               Include 006    25      MG/KG
                               Include 008    50      MG/KG
                               Include 001    0       MG/KG
                               Include 003    12.5    MG/KG
                               Include 005    25      MG/KG
                               Include 007    50      MG/KG























                                                             Page   1
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|             
                                           | 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Dilatation                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Dilatation                           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X     X  X     X  X  X     X     X  X  X  X  X|             
      Clear Cell Focus                     |                         X  X     X        X                    X         |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |             X                    X                                       |             
      Fatty Change                         |                   2                                3     2               |             
      Hepatodiaphragmatic Nodule           | X        X                 X           X     X                          X|             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Mixed Cell Focus                     | X                                                           X           X|             
      Necrosis                             |                               1                                          |             
      Pigmentation                         |                1                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                             +      |             
      Fat, Necrosis                        |                                     3                             3      |             
      Fat, Pigmentation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1  1     1           1           1  2  2     1  2  1  1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Duct, Metaplasia, Squamous           |             1                 1  1           1                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |    2                                                     2               |             
      Hyperplasia, Basal Cell              |    2                                   2                 2               |             
      Inflammation, Acute                  |                         1                                                |             
      Inflammation, Chronic                |                                        2                                 |             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                    1                     |             
      Hyperplasia                          |                                                    1                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|             
                                           | 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1     2     1  1     2  1  2  2  1  2  1     2  2  2     2  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
      Hyperplasia                          |                                                 1           2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          3                                                               |             
      Pars Distalis, Cyst                  | X              X     X     X  X  X     X        X           X            |             
      Pars Distalis, Hyperplasia           |                            3  3     3        2           3               |             
      Pars Intermedia, Atypia Cellular     |                               X                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  2     2  2                                2  2        1     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Dilatation                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                          X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            3                       1                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                        +                 +     +         |             
      Mediastinal, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|             
                                           | 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Hyperkeratosis                       |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   1      |             
      Edema                                |                                           2                              |             
      Foreign Body                         | 1     1  2           2     1                 1        1        1  1      |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                1                             1                          1|             
      Inflammation, Chronic Active         | 1  1     1        1        2     1  1  1  1                 1  1  1  1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Bacterium                    |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                          1               |             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                    2                     |             
      Inflammation, Acute                  |                      3     1        2              2     1  1        1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|             
                                           | 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +     +                     |             
      Lens, Cataract                       |                                              3     2                     |             
      Retina, Atrophy                      |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |          1  2  1  1     1  1  1  1     1  1  1  2  1  1  2  2  1  1  1  1|             
      Cortex, Mineralization               |    1                 1        1  1  1              1     1           1   |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|             
                                           | 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X  X   |             
      Clear Cell Focus                     |    X  X     X     X  X  X              X  X     X     X        X         |             
      Cyst                                 |                                     X                                    |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change                         |             2                       3                 2     2            |             
      Hepatodiaphragmatic Nodule           |    X                 X  X                                X               |             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Chronic                |                1                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                           2                              |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +                    +                 +            |             
      Fat, Necrosis                        |             2                             2                 3            |             
      Fat, Pigmentation                    |                      2                                                   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2     1     1     1        3  2  1        1     1              1     1  2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                            1                                             |             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                              1     3                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                     3              1        2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                        |             
      Foreign Body                         |                                                 4                        |             
      Inflammation, Chronic Active         |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|             
                                           | 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     1  1  1  2  2  1  2  2  1  1  2  2  2  2  2     1  2     2  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Focal Cellular Change                |                      2  1                                                |             
      Hyperplasia                          |                   1                             2                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            1                                            2|             
      Pars Distalis, Cyst                  |       X  X              X     X        X  X  X     X              X      |             
      Pars Distalis, Hyperplasia           |    4           2  3        3  3  1  2  3           2        2  2  2     3|             
      Pars Intermedia, Atypia Cellular     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1        1     1                    1  2           1        1        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Abscess                              |                                        3                                 |             
      Dilatation                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                 X     X     X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           1           2                  |             
                                            __________________________________________________________________________|             
   Vagina                                  | M        M                    M  M           M                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                    +        +            |             
      Mediastinal, Angiectasis             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3                     |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|             
                                           | 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                          1               |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                               3                    2                     |             
      Necrosis                             |                                                             4            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             1            |             
      Cyst Epithelial Inclusion            |             X                                                            |             
      Hyperkeratosis                       |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                X                                                         |             
      Hyperostosis                         |                X                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |          1                                   1                           |             
      Foreign Body                         |             1  1     1              1  1                 1               |             
      Hemorrhage                           |                                              2                           |             
      Infiltration Cellular, Histiocyte    |                   1                                                      |             
      Inflammation, Chronic Active         |    2  1        1     2  1  1           1        1     1        1  1  1   |             
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |             
      Pleura, Bacterium                    |                                              2                           |             
      Pleura, Inflammation, Acute          |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          2                                                               |             
      Foreign Body                         |                                  1                                       |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |             2        2  2                                               2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|             
                                           | 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1  2     2  1  2  1  1  1           1  1     1     2  1  1  1     1  1|             
      Cortex, Mineralization               | 1  1        1                             1  1                 1     1   |             
      Renal Tubule, Degeneration, Hyaline  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0                                      | 5|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  49        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  46        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Basophilic Focus                     | X                                                                        |     43     |
      Clear Cell Focus                     |                                                                          |     16     |
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Fatty Change                         |                                                                          |      7  2.3|
      Hepatodiaphragmatic Nodule           | X                                                                        |     11     |
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Necrosis                             |                                                                          |      2  1.5|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
      Fat, Necrosis                        |                                                                          |      5  2.6|
      Fat, Pigmentation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Acinus, Atrophy                      | 2                                                                        |     24  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Degeneration                         |                                                                          |      1  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      5  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0                                      | 5|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Foreign Body                         |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       | 2                                                                        |     39  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Focal Cellular Change                |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.0|
      Pars Distalis, Cyst                  |                                                                          |     18     |
      Pars Distalis, Hyperplasia           | 2                                                                        |     19  2.5|
      Pars Intermedia, Atypia Cellular     |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  | 2                                                                        |     17  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  48        |
      Abscess                              |                                                                          |      1  3.0|
      Dilatation                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  51        |
      Cyst                                 |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Dilatation                           |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0                                      | 5|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Mediastinal, Angiectasis             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Ectasia                              | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Depletion Lymphoid                   |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Acanthosis                           |                                                                          |      1  1.0|
      Cyst Epithelial Inclusion            |                                                                          |      2     |
      Hyperkeratosis                       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Developmental Malformation           |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Congestion                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5|                                                                       |            |
                             DAY ON TEST   | 2|                                                                       |            |
                                           | 8|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 3|                                                                       |      A     |
    0                                      | 5|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      3  1.3|
      Foreign Body                         |                                                                          |     15  1.1|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      4  1.0|
      Inflammation, Chronic Active         |                                                                          |     25  1.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Pleura, Bacterium                    |                                                                          |      1  2.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Bacterium                            |                                                                          |      2  1.5|
      Foreign Body                         |                                                                          |      1  1.0|
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute                  | 1                                                                        |     13  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      2  2.5|
      Retina, Atrophy                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Nephropathy                          | 1                                                                        |     38  1.2|
      Cortex, Mineralization               | 1                                                                        |     16  1.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|             
                                           | 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.5                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       2                  |             
      Mineralization                       |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X        X  X  X  X  X  X  X  X        X  X  X  X  X   |             
      Clear Cell Focus                     |    X  X  X     X  X  X     X  X           X                 X  X     X  X|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |       X                       X                       X                  |             
      Hepatodiaphragmatic Nodule           | X  X              X                                   X                  |             
      Hyperplasia                          |                                                                      2  2|             
      Mixed Cell Focus                     |             X                                                        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +        +                                                   |             
      Fat, Necrosis                        |    3        2        3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                  2                                       |             
      Acinus, Atrophy                      |    1        1           1  1                             2  1     1     2|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Duct, Metaplasia, Squamous           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        2                                 |             
      Hyperplasia, Basal Cell              |                   1                                                      |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                  2                 2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         2                                                |             
      Ulcer                                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  1  1  2  1  1  1        1     2  1  1  2  2     1  1  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|             
                                           | 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.5                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia                          |                      1                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     2                          1         |             
      Pars Distalis, Cyst                  | X     X  X     X     X  X  X        X  X  X  X  X        X     X        X|             
      Pars Distalis, Hyperplasia           | 2        2        1     2  3              2        4        2            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      C-Cell, Hyperplasia                  |    1     3        1  2     1     1                       2  1  2        1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mediastinum, Granuloma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                          X           X              X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                       +                          +  +                  |             
      Mediastinal, Ectasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|             
                                           | 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.5                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Neuron, Necrosis           |                                                                          |             
      Hippocampus, Neuron, Necrosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                   1      |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       2                  |             
      Foreign Body                         |       1           1  1           1        1                       1      |             
      Hemorrhage                           |                                           1                              |             
      Inflammation, Chronic Active         | 2  2  1  1  1  2  2  1     2  1  1  2  1  1  1  1  1  1  2  2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                1     1                 2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                     2                                    |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1     1  1  1  1     1  1  1  1  1  1     1     1           1  3  1|             
      Cortex, Mineralization               | 1  1  1                    1  1  1  1  1                             1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|             
                                           | 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    12.5                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|             
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|             
                                           | 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12.5                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    MG/KG                                  | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                   X  X     X     X           X              X        X   |             
      Congestion                           |                      2     2                                             |             
      Cyst                                 |                                           X                              |             
      Developmental Malformation           |                            X                                             |             
      Eosinophilic Focus                   |             X  X                    X                                    |             
      Hepatodiaphragmatic Nodule           |       X           X              X     X  X        X              X  X   |             
      Hyperplasia                          |       3                       2                             2  3         |             
      Mixed Cell Focus                     |                X  X              X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Necrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                                                          |             
      Acinus, Atrophy                      |    1     1     1              1  2     1  2        1  1     1  1  1  1  2|             
      Acinus, Hyperplasia                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                1              1                             1            |             
      Duct, Metaplasia, Squamous           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Basal Cell              |                2                    2                                    |             
      Hyperplasia, Focal, Squamous         |                                           2                              |             
      Inflammation, Acute                  |                                     2                                    |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  2  2  2  1  2     2  1  2        2        2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|             
                                           | 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12.5                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    MG/KG                                  | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                  1                                       |             
      Hyperplasia                          |          1                    1        2                             2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                       3  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                 2  1                  |             
      Pars Distalis, Cyst                  | X                    X        X  X  X     X        X     X  X        X   |             
      Pars Distalis, Hyperplasia           | 2                                3        1           2     3     2      |             
      Pars Intermedia, Cyst                |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                2  1  2           1        1  1        2              1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Mediastinum, Granuloma               |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X     X         |             
      Hyperplasia                          |       2                       3                                          |             
      Inflammation, Acute                  |                               1                                          |             
      Inflammation, Chronic                |                                                             1            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |    X  X           X           X                       X     X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                                                           3      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 M                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                         1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                     +                                    |             
      Mediastinal, Ectasia                 |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                               3                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|             
                                           | 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12.5                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    MG/KG                                  | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |          X     X                                   X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Neuron, Necrosis           |                                     2                                    |             
      Hippocampus, Neuron, Necrosis        |                                     4                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Foreign Body                         | 1           2        1        1        1  2                 1            |             
      Hemorrhage                           |             3                                               1            |             
      Inflammation, Chronic Active         | 1  1  1  1  1  1  2  2  1  2  2  1     1  1  1     1  1  2  2  1  1  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               2                                          |             
      Inflammation, Acute                  |                               2                                   2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                          +            |             
      Phthisis Bulbi                       |                                                             4            |             
      Lens, Cataract                       |                                  3                                       |             
      Retina, Atrophy                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  2  2  2  2  1  1     1  3  1  1  1  1     2     1     2  1     1     1|             
      Cortex, Mineralization               |                      1                                   1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|             
                                           | 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    12.5                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|             
    MG/KG                                  | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 7|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    12.5                                   | 1|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | X                                                                        |     44     |
      Clear Cell Focus                     | X                                                                        |     21     |
      Congestion                           |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Hepatodiaphragmatic Nodule           |                                                                          |     12     |
      Hyperplasia                          |                                                                          |      6  2.3|
      Mixed Cell Focus                     |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Metaplasia                           |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |     22  1.2|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Focal Cellular Change                |                                                                          |      3  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      3  1.7|
      Hyperplasia, Focal, Squamous         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 7|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    12.5                                   | 1|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       | 2                                                                        |     41  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      5  1.6|
      Pars Distalis, Cyst                  |                                                                          |     25     |
      Pars Distalis, Hyperplasia           | 2                                                                        |     15  2.2|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                                                          |     19  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Mediastinum, Granuloma               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  46        |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Cyst                                 |                                                                          |     10     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  51        |
      Dilatation                           |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 7|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    12.5                                   | 1|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  51        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  47        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  49        |
      Galactocele                          |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Cerebrum, Neuron, Necrosis           |                                                                          |      1  2.0|
      Hippocampus, Neuron, Necrosis        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |  51        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |     13  1.2|
      Hemorrhage                           |                                                                          |      3  1.7|
      Inflammation, Chronic Active         | 1                                                                        |     48  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 7|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    12.5                                   | 1|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      2  2.5|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Nephropathy                          |                                                                          |     37  1.3|
      Cortex, Mineralization               |                                                                          |     11  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|             
                                           | 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   1                                                      |             
      Ulcer                                |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X        X        X   |             
      Clear Cell Focus                     |          X     X  X        X     X  X     X                              |             
      Eosinophilic Focus                   |                X                                                         |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X                                   X   |             
      Hepatodiaphragmatic Nodule, Multiple |                      X                                                   |             
      Hyperplasia                          |                            3        2                       3            |             
      Mixed Cell Focus                     |                                  X                                       |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |    2  1           1           1  1        4     1  1  2        1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                1                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       2                  |             
      Hemorrhage                           |                                                 1                        |             
      Hyperkeratosis                       |                               1                                          |             
      Hyperplasia, Basal Cell              |       1              2        2                                3  3      |             
      Inflammation, Acute                  |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                   4      |             
      Perforation                          |                                                                   X      |             
      Ulcer                                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 1                                                                        |             
      Ulcer                                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|             
                                           | 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     2  2  3  1  1  2  2  2  2  2  2  1  2  1  2     1     1  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                        X                                 |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  1        3                    2  3      |             
      Pars Distalis, Cyst                  |       X  X        X     X  X  X           X  X  X     X     X  X        X|             
      Pars Distalis, Hyperplasia           |                2           1  3  2           2                    2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             3                          1  1  2              2  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                   X   |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        2                                 |             
      Hemorrhage                           |                                                                   4      |             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Acute                  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   M                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                              +  +                 +      |             
      Pancreatic, Ectasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                        2           3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|             
                                           | 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
      Pigmentation                         |                                                       2                  |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thyroid                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    X                                   X                 X           X   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Foreign Body                         | 1     1     1        2  1  1     1                          1        1   |             
      Hemorrhage                           |                   1                                                      |             
      Infiltration Cellular, Histiocyte    |                                                 3                        |             
      Inflammation, Chronic Active         | 1  2  2  2  2  2     1  1  1  1  2  2  1  1  1     1  1  1  1  1  1  1   |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 1                                                                        |             
      Foreign Body                         | 1     1     2                                      1                     |             
      Fungus                               |       X                                                                  |             
      Inflammation, Acute                  |       2  1  2                                      1  1                 1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|             
                                           | 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    MG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +                                                            |             
      Phthisis Bulbi                       |          4                                                               |             
      Synechia                             |             2                                                            |             
      Retina, Atrophy                      |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1     1  2        1  1  1  1     1  1     1  2  1  1     1        1  1|             
      Pigmentation                         |                                                                          |             
      Cortex, Mineralization               |       1     1     1  1        1  1     1           1                     |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|             
                                           | 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     |    X     X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X        X        X        X     X  X        X        X     X  X  X  X|             
      Eosinophilic Focus                   |    X                                      X        X                     |             
      Fatty Change                         |                         2                                                |             
      Hematopoietic Cell Proliferation     |    3                                                                     |             
      Hepatodiaphragmatic Nodule           |    X           X           X  X        X              X  X               |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Hyperplasia                          |                                                             2     2     2|             
      Mixed Cell Focus                     |                                                                          |             
      Serosa, Fibrosis                     |                2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis                        |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Ectopic Tissue                       |                X                             X                           |             
      Inflammation, Chronic                |                            1                                             |             
      Acinus, Atrophy                      |    1     1     2     1  3        1        1  2     1     1              1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |          1                                               1              1|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |       2                                                                  |             
      Hyperplasia, Basal Cell              |                                                          2               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation, Chronic Active         |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|             
                                           | 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  1  2  2  2     2     2     1  1  1  1  1  2  1     2     2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                         X           X                                    |             
      Hyperplasia                          |                                        2        1                        |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2           1                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          3                       2                                       |             
      Pars Distalis, Cyst                  |    X  X  X  X                    X  X        X     X           X  X      |             
      Pars Distalis, Hyperplasia           |                                                 2  1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2           1        3     1     1     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X           X                             X               |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |          X                       X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Dilatation                           |                      2                    2  3                           |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Glandular               |                                  2                                       |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   M                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                          +                       +                     |             
      Pancreatic, Ectasia                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|             
                                           | 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                             3            |             
      Pigmentation                         |                                                                          |             
      Capsule, Fibrosis                    |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thyroid                      |                                                                      X   |             
      Hemorrhage                           |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                X           X                                         X   |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                           X                              |             
      Inflammation, Chronic                |                            3                                             |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |       2           1                                                      |             
      Foreign Body                         |          1        1     1     2        1        1  1     1  1     1      |             
      Hemorrhage                           |                   2           2                                          |             
      Infiltration Cellular, Histiocyte    |       2                                                                  |             
      Inflammation, Chronic Active         |    2     2  2  1     1  1  1  1  1  1  1     1  1  1  1  1     1  2  2  1|             
      Mediastinum, Inflammation, Acute     |                               2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Foreign Body                         |                                                          1               |             
      Fungus                               |                                                                          |             
      Inflammation, Acute                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|             
                                           | 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    25                                     | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|             
    MG/KG                                  | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Synechia                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  1  1  1  2     1  2     1     1  1  1  1     1  1  1  3  1  1  1  1|             
      Pigmentation                         |                            2                                             |             
      Cortex, Mineralization               |             1                                      1  1  1  1     1     1|             
      Renal Tubule, Degeneration, Hyaline  |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    25                                     | 7|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | X                                                                        |     42     |
      Clear Cell Focus                     | X                                                                        |     20     |
      Eosinophilic Focus                   |                                                                          |      4     |
      Fatty Change                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      9     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia                          | 2                                                                        |      7  2.3|
      Mixed Cell Focus                     |                                                                          |      1     |
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Cyst                                 |                                                                          |      1     |
      Ectopic Tissue                       |                                                                          |      2     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |     21  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  50        |
      Focal Cellular Change                |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  51        |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      2  1.5|
      Hyperplasia, Basal Cell              |                                                                          |      6  2.2|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Perforation                          |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    25                                     | 7|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
      Erosion                              |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Cardiomyopathy                       | 1                                                                        |     42  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Clear Cell Focus                     |                                                                          |      3     |
      Hyperplasia                          | 1                                                                        |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  48        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Pars Distalis, Angiectasis           | 2                                                                        |      7  2.3|
      Pars Distalis, Cyst                  |                                                                          |     23     |
      Pars Distalis, Hyperplasia           |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  51        |
      C-Cell, Hyperplasia                  | 1                                                                        |     13  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                                                        |  51        |
      Cyst                                 |                                                                          |      5     |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +                                                                        |  50        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +                                                                        |  50        |
      Dilatation                           | 2                                                                        |      5  2.2|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    25                                     | 7|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Hyperplasia, Re Cell                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  50        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  50        |
      Ectopic Thyroid                      |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |  51        |
      Galactocele                          |                                                                          |      7     |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7|                                                                       |            |
                             DAY ON TEST   | 3|                                                                       |            |
                                           | 1|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS FEMALE                 | 0|                                                                       |      T     |
                               ANIMAL ID   | 4|                                                                       |      A     |
    25                                     | 7|                                                                       |      L     |
    MG/KG                                  | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Edema                                |                                                                          |      2  1.5|
      Foreign Body                         |                                                                          |     19  1.1|
      Hemorrhage                           |                                                                          |      3  1.7|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.5|
      Inflammation, Chronic Active         | 1                                                                        |     43  1.3|
      Mediastinum, Inflammation, Acute     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      5  1.2|
      Fungus                               |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Phthisis Bulbi                       |                                                                          |      1  4.0|
      Synechia                             |                                                                          |      1  2.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Nephropathy                          | 1                                                                        |     39  1.2|
      Pigmentation                         |                                                                          |      1  2.0|
      Cortex, Mineralization               | 1                                                                        |     16  1.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|             
                                           | 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    50                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X           X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X                       X     X  X        X  X              X     X      |             
      Eosinophilic Focus                   |    X           X           X                       X                 X   |             
      Fatty Change, Focal                  |                                                 2                 1      |             
      Fatty Change                         |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X        X                                      X      |             
      Hyperplasia                          |                3  3                                                      |             
      Mixed Cell Focus                     | X                    X              X                                    |             
      Necrosis                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Fat, Fibrosis                        |                         1                                                |             
      Fat, Hemorrhage                      |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                   1                                                      |             
      Acinus, Atrophy                      |    2           1     2  2     1  2  3     2  2        1                 2|             
      Acinus, Hyperplasia                  |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Inflammation, Acute            |                         2                                                |             
      Duct, Metaplasia, Squamous           |                1              1                                          |             
      Duct, Mineralization                 |                         2                                                |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Cystic                  |                      4                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |             3                                            3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                          2  1                                 |             
      Ulcer                                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     1  1  2     2  2  1  1     1  2  2        2  2  2  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|             
                                           | 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    50                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          2                                                               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 1                 1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | X  X                    X     X        X  X                 X     X     X|             
      Pars Distalis, Hyperplasia           |       1                    2  2  2     2  1  3     2        2        2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X                              |             
      C-Cell, Hyperplasia                  |                1                 2  2                             1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                  X        X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |          M  +                                                           +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +           +           +     +                                 |             
      Lumbar, Necrosis                     |          3                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Necrosis                             |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Necrosis                             |          1                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|             
                                           | 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    50                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                       2                  |             
      Hematopoietic Cell Proliferation     |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Galactocele                          |                                  X  X  X                 X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         2                                                |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              3                 2         |             
      Foreign Body                         |                               1                 1  1     1  1  1         |             
      Hemorrhage                           |          2  2                                                            |             
      Infiltration Cellular, Histiocyte    |                         1                                                |             
      Inflammation, Chronic Active         | 2  1  1        2  2  1     2  2  2  1  1  3  1  1  1  1     1  1  1  1   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               | 2                                                                        |             
      Inflammation, Acute                  | 2                          2        2                                    |             
      Respiratory Epithelium, Metaplasia   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|             
                                           | 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    50                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 2  1  1           1  1  2     1  2  1  1  1     1  1     1  1  1  1  2   |             
      Cortex, Mineralization               |             1                                                  1         |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    50                                     | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|      L     |
    MG/KG                                  | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Ectopic Tissue                       |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                        2                                 |      1  2.0|
      Basophilic Focus                     | X     X  X  X     X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X|     41     |
      Clear Cell Focus                     |                            X                       X              X  X   |     12     |
      Eosinophilic Focus                   |       X                    X                             X        X      |      9     |
      Fatty Change, Focal                  |                                                                          |      2  1.5|
      Fatty Change                         |          3                                                               |      1  3.0|
      Hepatodiaphragmatic Nodule           |                      X                       X        X  X               |      7     |
      Hyperplasia                          |       2              2                 2                                 |      5  2.4|
      Mixed Cell Focus                     |                      X                 X     X                       X   |      7     |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Fibrosis                        |                                                                          |      1  1.0|
      Fat, Hemorrhage                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia                           |                                                                          |      1  1.0|
      Acinus, Atrophy                      | 1     3     2        1  1  1     2     1     1  1  2           2  1  1  1|     26  1.6|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Inflammation, Acute            |                                                                          |      1  2.0|
      Duct, Metaplasia, Squamous           |             1                                                            |      3  1.0|
      Duct, Mineralization                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                           2                              |      1  2.0|
      Hyperplasia, Basal Cell              |          3                                1     2                        |      3  2.0|
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |          3                                                               |      1  3.0|
      Ulcer                                |    1                                                                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Erosion                              |                                                 1                        |      4  1.5|
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    50                                     | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|      L     |
    MG/KG                                  | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2           2  1  1  1  1  1  1  2  1  1  2     2  1  2  2  2  2|     41  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                      1                                            1      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                           2     1                 2      |      3  1.7|
      Pars Distalis, Cyst                  |    X        X                 X  X     X              X  X        X     X|     18     |
      Pars Distalis, Hyperplasia           | 2  3        4                    2  2  1  3        3              2      |     20  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 2     1     1     1              1     1     1                           |     11  1.3|
      Follicular Cell, Hyperplasia         |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              X                           |      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X     X                          X|      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                             M            |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Re Cell                 |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                                   +      |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    50                                     | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|      L     |
    MG/KG                                  | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Necrosis                     |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Galactocele                          |                   X                                                      |      5     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |             X                                                            |      1     |
      Ulcer                                |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |    2                                                                     |      3  2.3|
      Foreign Body                         |    1     2              1  1                          1                 1|     12  1.1|
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |                            3                                   2         |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3|            |
                                           | 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    50                                     | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|      L     |
    MG/KG                                  | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 3     1  2  2     1  2  1  1  1  1  1  1  1  2  1  1  2  3     1  1  1  2|     42  1.4|
      Alveolar Epithelium, Hyperplasia     |                         1        2                                       |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute                  |          1                    2     2                          1         |      7  1.7|
      Respiratory Epithelium, Metaplasia   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   1        |
      Retina, Atrophy                      |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          |       2  1        1     1  1  1  1  1  1  1  1     1  1  1           1  2|     34  1.2|
      Cortex, Mineralization               |                   1        1     1     1     1     1  1  1               |     10  1.0|
      Renal Tubule, Hyperplasia            |                            2                                             |      1  2.0|
      Transitional Epithelium, Hyperplasia |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|             
                                           | 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/KG                                  | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Dilatation                           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X  X              X           X        X        X     X  X      |             
      Clear Cell Focus                     | X        X  X  X           X        X  X  X     X     X  X     X        X|             
      Eosinophilic Focus                   |    X     X                             X  X                              |             
      Fatty Change, Focal                  |                   1     2        1           1           1     1     1   |             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                   +                           |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    1        2  1  2     2           1  2  2                    3        1|             
      Acinus, Hyperplasia                  |    1  3  3  1  3                    3     2        1                    3|             
      Artery, Inflammation, Chronic Active |             3                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |                                     1                 1  1     1         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                          3               |             
      Hyperplasia, Diffuse, Squamous       |          2        2  2  2        2                          2            |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Ulcer                                |       2  2           1  2        2                          3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2  3                                                     1        1   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |          1                                                           1   |             
      Ulcer                                |    2     2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       | 3  1  3  2  2  2  2  1  2  2  2  1  2  2  1  2  2  2  3  2  1  2  2  2  1|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|             
                                           | 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/KG                                  | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |       2                                                              1   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        2        1  2  1  1                 2  1  2     1  3  1     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 1  2        1           3  2           2  2                    4  1  2   |             
      Pars Intermedia, Cyst                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            1     1           1           2           2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                1        1|             
      Concretion                           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
      Interstitial Cell, Hyperplasia       |                                     3           2           2            |             
      Seminiferous Tubule, Atrophy         |       2                 3                       2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +     +                       +     +        +   |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                      3   |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|             
                                           | 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/KG                                  | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                          2               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             1                                                            |             
      Mineralization                       |                                                          2               |             
      Hippocampus, Neuron, Necrosis        |                                           2                              |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                      1   |             
      Foreign Body                         |                2                                   1                     |             
      Hemorrhage                           |                1                                                         |             
      Infiltration Cellular, Histiocyte    |                   1                                                      |             
      Inflammation, Chronic Active         | 1     1  2  2              2  3     2  1  2  1  2  2  2  2     1  1  1  2|             
      Alveolar Epithelium, Hyperplasia     |          3                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                 1                        |             
      Fungus                               | 2     2                       2                                          |             
      Inflammation, Acute                  | 2     2        1              2        2  2     2     1  1     1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|             
                                           | 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    MG/KG                                  | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       2                       2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +              +  +                       +  +     +        +|             
      Lens, Cataract                       |          2  2              1  2                       2  2     2        2|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                    X     X                                    |             
      Nephropathy                          | 2  2  3  3  2  1  2  2  2  3  3  1  2  3  2  2  2  3  2  3  2  3  2  3  3|             
      Cortex, Mineralization               |       1  1                                                           2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|             
                                           | 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    MG/KG                                  | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X           X  X        X                 X  X     X  X  X  X  X     X|             
      Clear Cell Focus                     | X  X           X     X     X           X     X        X  X  X     X     X|             
      Eosinophilic Focus                   |    X                             X                                       |             
      Fatty Change, Focal                  |       1                       2     1     1        1                 1   |             
      Hepatodiaphragmatic Nodule           |                                           X                       X      |             
      Mixed Cell Focus                     |                                                          X               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                                                                 +   |             
      Fat, Inflammation, Chronic Active    | 2                                                                        |             
      Fat, Necrosis                        |    4                                                                 4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  2           1  1  2     2     2        1        1  1  2  2     2      |             
      Acinus, Hyperplasia                  | 2  2                 2              1              2  1  2  2     2     2|             
      Artery, Inflammation, Chronic Active |                                                       1                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |                            1           1                 1               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     1                                    |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Diffuse, Squamous       |       2                       2     2           2                    2   |             
      Hyperplasia, Focal, Squamous         |                                                                         3|             
      Ulcer                                |       2                                         2                    2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1  3  1                          1           2                 2   |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                               3                                          |             
      Cardiomyopathy                       | 3  2  2  2     2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  1  3  2  2  3|             
      Inflammation, Acute                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|             
                                           | 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    MG/KG                                  | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     1  1                    1     2              2        2  3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  1           2                 1                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X                                               X        X   |             
      Pars Distalis, Hemorrhage            |                                                       3                  |             
      Pars Distalis, Hyperplasia           |             1                                      2  1                  |             
      Pars Intermedia, Cyst                |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1        1     2              1  2              1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      1                                   1     2         |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       2                  |             
      Interstitial Cell, Hyperplasia       |       1     2     1              1                    1                 1|             
      Seminiferous Tubule, Atrophy         |       3                                               1              3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +                                         +                 +  +|             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Ectasia                 |                                                                         1|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|             
                                           | 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    MG/KG                                  | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                       3                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  M  +  +  +  M  +  M  +  +  M  +  M  +  +  +  +  +  +|             
      Galactocele                          | X                 X     X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                                                          |             
      Hippocampus, Neuron, Necrosis        |                               1                                2     1   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                                           2                              |             
      Edema                                |                                                                          |             
      Foreign Body                         |             1     1     1                                2           1   |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1                                                      |             
      Inflammation, Chronic Active         | 2  2     3     2        1  2  2        2  1  1  1  1  2  2  1  1  2     2|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               | 2     2        2  1     3     2     3                    3               |             
      Inflammation, Acute                  | 2     3        2  2  1  2     2     2  1           2     3  2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|             
                             DAY ON TEST   | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|             
                                           | 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0                                      | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    MG/KG                                  | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +           +        +  +                 +     +        +  +  +      |             
      Lens, Cataract                       | 2  2           2        2  2                 2     2        2  2  2      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X           X           X                                             |             
      Nephropathy                          | 3  3  2  1  2  3  2  2  3  3  3  2  2  2  1  3  3  2  2  2  2  3  2  2  3|             
      Cortex, Mineralization               |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                 X     X                  |             
      Calculus Micro Observation Only      |                                                 X     X                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1|                                                                    |            |
                             DAY ON TEST   | 1| 1|                                                                    |            |
                                           | 5| 3|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 0| 0|                                                                    |      A     |
    0                                      | 7| 7|                                                                    |      L     |
    MG/KG                                  | 6| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |  52        |
      Perforation                          |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  45        |
      Dilatation                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                                                                     |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                                                                     |  48        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |  52        |
      Basophilic Focus                     | X                                                                        |     23     |
      Clear Cell Focus                     |                                                                          |     25     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Fatty Change, Focal                  |                                                                          |     13  1.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   6        |
      Fat, Inflammation, Chronic Active    |                                                                          |      1  2.0|
      Fat, Necrosis                        | 1                                                                        |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |  52        |
      Acinus, Atrophy                      | 2  1                                                                     |     25  1.6|
      Acinus, Hyperplasia                  | 3                                                                        |     20  2.1|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
      Duct, Metaplasia, Squamous           |                                                                          |      7  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |  52        |
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Diffuse, Squamous       |                                                                          |     11  2.0|
      Hyperplasia, Focal, Squamous         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      9  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |  52        |
      Erosion                              |                                                                          |     10  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Ulcer                                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1|                                                                    |            |
                             DAY ON TEST   | 1| 1|                                                                    |            |
                                           | 5| 3|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 0| 0|                                                                    |      A     |
    0                                      | 7| 7|                                                                    |      L     |
    MG/KG                                  | 6| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
      Bacterium                            |                                                                          |      1  3.0|
      Cardiomyopathy                       | 2  1                                                                     |     51  1.9|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |     21  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |  52        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           | 2                                                                        |     14  1.9|
      Pars Intermedia, Cyst                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |  52        |
      C-Cell, Hyperplasia                  |                                                                          |     11  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                                                                     |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |  52        |
      Atrophy                              |                                                                          |      5  1.2|
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |  52        |
      Inflammation                         |                                                                          |      2  2.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      9  1.6|
      Seminiferous Tubule, Atrophy         |                                                                          |      6  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1|                                                                    |            |
                             DAY ON TEST   | 1| 1|                                                                    |            |
                                           | 5| 3|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 0| 0|                                                                    |      A     |
    0                                      | 7| 7|                                                                    |      L     |
    MG/KG                                  | 6| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                                                                     |  13        |
      Mediastinal, Angiectasis             |    1                                                                     |      1  1.0|
      Mediastinal, Ectasia                 |                                                                          |      1  1.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |  52        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |  52        |
      Infiltration Cellular                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |  52        |
      Depletion Lymphoid                   |    1                                                                     |      1  1.0|
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |  51        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  36        |
      Galactocele                          |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
      Fracture                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +                                                                     |  52        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
      Hemorrhage                           | 1                                                                        |      2  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Hippocampus, Neuron, Necrosis        |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +                                                                     |  52        |
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1|                                                                    |            |
                             DAY ON TEST   | 1| 1|                                                                    |            |
                                           | 5| 3|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 0| 0|                                                                    |      A     |
    0                                      | 7| 7|                                                                    |      L     |
    MG/KG                                  | 6| 7|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Bacterium                            |    2                                                                     |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  1.0|
      Foreign Body                         |    1                                                                     |      8  1.3|
      Hemorrhage                           |    3                                                                     |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.0|
      Inflammation, Chronic Active         | 2                                                                        |     37  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
      Foreign Body                         |                                                                          |      1  1.0|
      Fungus                               |                                                                          |     11  2.2|
      Inflammation, Acute                  | 1                                                                        |     24  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  18        |
      Lens, Cataract                       |                                                                          |     18  1.9|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |  52        |
      Cyst                                 |                                                                          |      6     |
      Nephropathy                          | 2                                                                        |     51  2.3|
      Cortex, Mineralization               |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Calculus Gross Observation           |                                                                          |      2     |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|             
                                           | 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 1                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 1                                                                        |             
      Ulcer                                |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 2                                                                        |             
      Basophilic Focus                     |    X        X     X        X     X        X           X     X  X  X     X|             
      Clear Cell Focus                     | X  X  X  X  X  X     X  X  X  X  X  X     X                    X        X|             
      Congestion                           |                                                          2               |             
      Developmental Malformation           | X                                                                        |             
      Eosinophilic Focus                   |                                        X     X     X           X         |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |       1  1              1     1  1  1                 1     1  1        1|             
      Hepatodiaphragmatic Nodule           |                            X                                      X     X|             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                             X            |             
      Necrosis                             | 2                                                                        |             
      Vein, Dilatation                     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                       +                  |             
      Fat, Necrosis                        |                               2                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Acinus, Atrophy                      |    1  2        1              1  2     2  2  2     2  2     2           2|             
      Acinus, Hyperplasia                  |                1           2     2           2                 2         |             
      Artery, Inflammation, Chronic Active |                                                 2                        |             
      Artery, Pigmentation                 |                                                 2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Metaplasia, Squamous           |       1                                                     1            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Diffuse, Squamous       |                                                       2                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 2                                                                        |             
      Erosion                              | 2                                                  1     2        1      |             
      Hyperplasia                          |                            1                                             |             
      Inflammation, Chronic Active         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|             
                                           | 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 1                                                                        |             
      Cardiomyopathy                       | 1  2  2  2  3  3  2  2  2  2  2  1  2  2  2  3  2  1  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Hyperplasia                          |             3  2  2                       1              1  2  1         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2           1                                             |             
      Pars Distalis, Cyst                  |             X           X     X                          X               |             
      Pars Distalis, Hyperplasia           |       2        1     2        2     3     2        2     2     1  2  1   |             
      Pars Intermedia, Cyst                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     1                                   1        1        1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    1  1              1                 2           1  1  2        1     1|             
      Seminiferous Tubule, Atrophy         |    3           3                       3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                   +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|             
                                           | 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Depletion Lymphoid                   | 2                                                                        |             
      Necrosis                             |                                                                      2   |             
      Pigmentation                         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibrosis                             |                                                 2                        |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Epithelial Cell, Hyperplasia         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Mineralization                       |                                                 1                        |             
      Necrosis                             |                                                 3                        |             
      Pigmentation                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hippocampus, Neuron, Necrosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            | 1                                                                        |             
      Congestion                           | 3                                                                        |             
      Edema                                |                                                             2            |             
      Fibrosis                             |                                     1                                    |             
      Foreign Body                         | 1  1           1  1  1     1  1     1  1              1                 1|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1                                                            |             
      Inflammation, Chronic Active         |    2  3  2     1  2  1  1  2  2  2  1  2  1  2  1     2     1        1  1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|             
                             DAY ON TEST   | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|             
                                           | 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bacterium                            | 2                                                                        |             
      Foreign Body                         |                                              2                           |             
      Fungus                               |                            2                                             |             
      Inflammation, Acute                  |                1           2                 2  1  1           1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +              +  +  +  +     +     +        +        +|             
      Lens, Cataract                       |    2              2              2  2  2  2     2     2        2        2|             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    2  2  2  2  2  3  1  1  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2|             
      Cortex, Mineralization               |                                                                1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|             
                                           | 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Bacterium                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A|             
      Bacterium                            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Basophilic Focus                     | X     X                    X     X  X  X  X  X     X                     |             
      Clear Cell Focus                     | X  X  X           X     X  X           X  X  X     X        X  X  X      |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |    X     X                 X                                             |             
      Fatty Change, Diffuse                |                                                 3                        |             
      Fatty Change, Focal                  | 1     1  1  1           1                                      1     1   |             
      Hepatodiaphragmatic Nodule           |                      X  X                                                |             
      Hyperplasia                          |                                              2                           |             
      Mixed Cell Focus                     |                                           X                              |             
      Necrosis                             |                      2                                                   |             
      Vein, Dilatation                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                         1|             
      Acinus, Atrophy                      | 2                 2     2        1  2  1        2  2  1  2        2  1  1|             
      Acinus, Hyperplasia                  |             1     2     1                                                |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Artery, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1                                                               |             
      Duct, Metaplasia, Squamous           | 1                 1        1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Diffuse, Squamous       |                                                 3                        |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Erosion                              |                                        1        2                    2   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|             
                                           | 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Cardiomyopathy                       | 2  1  2  2  2  1  2  3  1  2  2  2  2  2  1  1  2     2  2     1     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                         1|             
      Hyperplasia                          |    1  2  1              1        1        1  1                           |             
      Necrosis                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               3              3                           |             
      Pars Distalis, Cyst                  |                X        X              X                                 |             
      Pars Distalis, Hyperplasia           | 1                    3  1           3        2                    3     2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1        1              1              1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       1                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    1  1     1        2  2     2     2           1     1              1   |             
      Seminiferous Tubule, Atrophy         |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |          1                                1                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|             
                                           | 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                         2|             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis                             |                                                                         3|             
      Pigmentation                         |                                                 2           2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           1                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hippocampus, Neuron, Necrosis        |                                                          3               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                                                             3            |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Foreign Body                         | 1  1  1  1     1     1  1     1  1  2     1     1  1     1     2         |             
      Hemorrhage                           |                                                    3  2                  |             
      Infiltration Cellular, Histiocyte    |                                  1     1                                 |             
      Inflammation, Chronic Active         | 1  1  2  1  2  1     1  2  2  1     1     1  3  2  1  1  2        1  1  1|             
      Alveolar Epithelium, Hyperplasia     |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|             
                                           | 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    12.5                                   | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bacterium                            |                                                                          |             
      Foreign Body                         |                                                                      2   |             
      Fungus                               |             3     2                                                      |             
      Inflammation, Acute                  |             2     2        1           1           2              1  2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +  +  +        +  +              +  +  +        +               |             
      Lens, Cataract                       | 2     2  2  2  2           2              2  2  2        2               |             
      Retina, Atrophy                      |                         3                       2                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                         1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1  2  2  2  2  2  2  2  1  1  1  1  1  2  2  2  3  2  2  2     1  1  1  2|             
      Cortex, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                  X                                       |             
      Calculus Micro Observation Only      |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    12.5                                   | 4|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  49        |
      Bacterium                            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  48        |
      Bacterium                            |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |     20     |
      Clear Cell Focus                     |                                                                          |     28     |
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      7     |
      Fatty Change, Diffuse                |                                                                          |      1  3.0|
      Fatty Change, Focal                  |                                                                          |     17  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      5     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                                                                          |      2  2.0|
      Vein, Dilatation                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Acinus, Atrophy                      | 2                                                                        |     26  1.7|
      Acinus, Hyperplasia                  |                                                                          |      8  1.6|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Artery, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  50        |
      Hyperplasia, Diffuse, Squamous       | 2                                                                        |      3  2.3|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    12.5                                   | 4|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Bacterium                            |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      7  1.6|
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Cardiomyopathy                       | 2                                                                        |     48  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |     14  1.4|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  51        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      4  2.3|
      Pars Distalis, Cyst                  |                                                                          |      7     |
      Pars Distalis, Hyperplasia           |                                                                          |     18  1.9|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  50        |
      C-Cell, Hyperplasia                  |                                                                          |      9  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  51        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    12.5                                   | 4|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 1                                                                        |     20  1.3|
      Seminiferous Tubule, Atrophy         |                                                                          |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  51        |
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  51        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Pigmentation                         |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                                                                        |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M                                                                        |  44        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  51        |
      Abscess                              | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  51        |
      Hyperostosis                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |  51        |
      Atrophy                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  50        |
      Hippocampus, Neuron, Necrosis        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 8|                                                                       |            |
                                           | 6|                                                                       |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0|                                                                       |      O     |
   FISCHER 344 RATS MALE                   | 0|                                                                       |      T     |
                               ANIMAL ID   | 1|                                                                       |      A     |
    12.5                                   | 4|                                                                       |      L     |
    MG/KG                                  | 0|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                                        |  48        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      2  3.0|
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |     26  1.1|
      Hemorrhage                           |                                                                          |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  1.0|
      Inflammation, Chronic Active         | 1                                                                        |     40  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      2  2.0|
      Fungus                               |                                                                          |      3  2.3|
      Inflammation, Acute                  |                                                                          |     13  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |  22        |
      Lens, Cataract                       | 2                                                                        |     21  2.0|
      Retina, Atrophy                      |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Bacterium                            |                                                                          |      1  1.0|
      Necrosis                             | 2                                                                        |      1  2.0|
      Nephropathy                          | 2                                                                        |     49  1.8|
      Cortex, Mineralization               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  51        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|             
                                           | 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    25                                     | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X  X  X  X  X  X  X        X  X        X  X  X  X  X  X  X   |             
      Clear Cell Focus                     | X  X  X     X  X     X     X  X        X     X        X     X  X  X  X  X|             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                               X                       X                  |             
      Fatty Change, Diffuse                |                                                 2                        |             
      Fatty Change, Focal                  | 1  2           1  2                 1  1     1              1  1  1      |             
      Hepatodiaphragmatic Nodule           |                      X                 X     X                 X         |             
      Mixed Cell Focus                     |    X                 X     X                    X              X         |             
      Necrosis                             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Mineralization                  |                                     1                                    |             
      Fat, Necrosis                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                         2                                                |             
      Acinus, Atrophy                      | 2  2  2  1  1  2           2        2  1  2     1  2  3     1     4  1  2|             
      Acinus, Hyperplasia                  |                                        3                             1   |             
      Artery, Hyperplasia                  |                                        3                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Duct, Metaplasia, Squamous           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                   3                                                      |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Cystic                  |                            3                                             |             
      Hyperplasia, Diffuse, Squamous       |                   2                 3           2        3               |             
      Hyperplasia, Focal, Squamous         |                                           1                              |             
      Ulcer                                |                                     2           2        2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  1                                       |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
      Abscess                              |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|             
                                           | 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    25                                     | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3     2  3  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2                          1  1  2  1                 1  1  3  1  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        2                                 |             
      Pars Distalis, Cyst                  | X                       X     X                       X           2      |             
      Pars Distalis, Hyperplasia           |    2  3              3  2           2  3              3              3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1                       3        1              1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     1                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    2                     |             
      Interstitial Cell, Hyperplasia       |                      2                    2     2        1     1  1     3|             
      Seminiferous Tubule, Atrophy         |                                  3  3           3                 3      |             
      Seminiferous Tubule, Mineralization  |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                   +  +           +        +                              |             
      Pancreatic, Degeneration             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|             
                                           | 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    25                                     | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                   3                       2                       3      |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           X                    X         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                 X                        |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |    1                                                                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Neuron, Necrosis         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Acute                  |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Edema                                |                                                                          |             
      Foreign Body                         |    2  1     1  1     1     1  1        2           1  1     1           1|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                        2           1                     |             
      Inflammation, Acute                  |                                                 2                        |             
      Inflammation, Chronic Active         | 2  2  1     1  2  2  1  1  3  1  1  1  1  2  2  2     1  1  2  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|             
                                           | 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    25                                     | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                    1              2      |             
      Fungus                               |                   3                                                      |             
      Inflammation, Acute                  |             2     2                 1              1     2     1  2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Erosion                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Perforation                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +     +        +        +        +  +                 +     +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |             2                                                            |             
      Lens, Cataract                       | 2  2  2     2        2        2        1  2                 2     2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                     3                                    |             
      Nephropathy                          | 2  2  2  1  2  2  1  2  2  3  2  1  2  2  2  2  3  3  2  2  2  2  1  2  1|             
      Transitional Epithelium, Hyperplasia |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                 X                        |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|             
                             DAY ON TEST   | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|             
                                           | 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    25                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                     3                                    |             
      Perforation                          |    2                                3                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Dilatation                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X                    X        X  X  X  X        X            |             
      Clear Cell Focus                     |       X  X  X        X        X  X     X  X  X  X  X        X  X     X   |             
      Cyst                                 |                         X                                                |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  | 1           1                          1     1  1           1  1         |             
      Hepatodiaphragmatic Nodule           |                                                 X  X              X      |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                                                          |             
      Acinus, Atrophy                      |    2        2     2  1  1  2                    1  1           2         |             
      Acinus, Hyperplasia                  |                               2                                          |             
      Artery, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     1                                    |             
      Duct, Metaplasia, Squamous           |                                                 1  1        1            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                     1                                    |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Diffuse, Squamous       |                         2                                                |             
      Hyperplasia, Focal, Squamous         |                2                                                         |             
      Ulcer                                |                         3  2                                            1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 3                          1                                            1|             
      Hyperplasia                          |                      1                    1                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|             
                             DAY ON TEST   | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|             
                                           | 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    25                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1  1  1  1  2  2  2  2  1     2  1  2  2  2  2  1  2  2  1     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                 1        1                 1  1        2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X  X              X        X                 X  X                     |             
      Pars Distalis, Hyperplasia           |       1                    1  2        2        3  1        3        3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2                       1              1        1     1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                2                                                         |             
      Degeneration                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4                                                                        |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  1                    1                 1           1     1        2  2|             
      Seminiferous Tubule, Atrophy         |                         2                 3                 2  3         |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Pancreatic, Degeneration             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|             
                             DAY ON TEST   | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|             
                                           | 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    25                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Infiltration Cellular, Histiocyte    | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                3                                                         |             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Necrosis                             |                         2                                                |             
      Pigmentation                         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |                            4                                             |             
      Hyperkeratosis                       |                         2                                                |             
      Thrombosis                           |                            3                                             |             
      Ulcer                                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Neuron, Necrosis         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |    2                                                                     |             
      Edema                                | 1  2                                                              1      |             
      Foreign Body                         |    2  1     1     1           1        2        1        1  2  1  2  1   |             
      Hemorrhage                           |                                                                   2      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  | 4  2                                                                     |             
      Inflammation, Chronic Active         |       2  1  2     1  1        1  2     1  2  1  1  2  1     2        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|             
                             DAY ON TEST   | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|             
                                           | 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    25                                     | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
    MG/KG                                  | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2  3     1                                 |             
      Pleura, Inflammation, Acute          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    2                                                                     |             
      Fungus                               |                3                                                         |             
      Inflammation, Acute                  | 2  3     1     2     2              2                 1                  |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                     4                                    |             
      Erosion                              |                                                                   1      |             
      Hemorrhage                           |                                                                   1      |             
      Perforation                          |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                          +     +        +     +        +     +   |             
      Hemorrhage                           |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Lens, Cataract                       |       3                          2              2     2        2     2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                X         |             
      Inflammation, Acute                  |                                                                          |             
      Nephropathy                          | 1  2  2  1  2     1  2  2  1  2  2  1  2  2  1  2  2  2     2  2     2  1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                            X                    X                        |             
      Calculus Micro Observation Only      |                            X                    X                        |             
      Hemorrhage                           |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7|                                                                    |            |
                             DAY ON TEST   | 9| 2|                                                                    |            |
                                           | 2| 5|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    25                                     | 0| 1|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |  52        |
      Abscess                              |                                                                          |      1  3.0|
      Perforation                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  50        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                                                                     |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |  52        |
      Basophilic Focus                     |    X                                                                     |     26     |
      Clear Cell Focus                     | X  X                                                                     |     32     |
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      2     |
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |    1                                                                     |     18  1.1|
      Hepatodiaphragmatic Nodule           | X                                                                        |      8     |
      Mixed Cell Focus                     |                                                                          |      5     |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Mineralization                  |                                                                          |      1  1.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |  52        |
      Metaplasia                           |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1                                                                        |     27  1.7|
      Acinus, Hyperplasia                  |                                                                          |      3  2.0|
      Artery, Hyperplasia                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |  52        |
      Erosion                              |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Hyperplasia, Diffuse, Squamous       | 2                                                                        |      6  2.3|
      Hyperplasia, Focal, Squamous         |                                                                          |      2  1.5|
      Ulcer                                | 1                                                                        |      7  1.9|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7|                                                                    |            |
                             DAY ON TEST   | 9| 2|                                                                    |            |
                                           | 2| 5|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    25                                     | 0| 1|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      4  1.5|
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Abscess                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
      Cardiomyopathy                       | 2  1                                                                     |     47  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |     17  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                                                                     |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |  51        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  | X                                                                        |     12  2.0|
      Pars Distalis, Hyperplasia           | 2                                                                        |     17  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |  51        |
      C-Cell, Hyperplasia                  |                                                                          |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |  52        |
      Atypia Cellular                      |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                                                                     |  52        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |  52        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |  52        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |  52        |
      Inflammation                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7|                                                                    |            |
                             DAY ON TEST   | 9| 2|                                                                    |            |
                                           | 2| 5|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    25                                     | 0| 1|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 2                                                                        |     16  1.5|
      Seminiferous Tubule, Atrophy         |                                                                          |      8  2.8|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
      Degeneration                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Pancreatic, Degeneration             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |  52        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |  52        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |  47        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  45        |
      Galactocele                          |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
      Fracture                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +                                                                     |  51        |
      Atrophy                              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7|                                                                    |            |
                             DAY ON TEST   | 9| 2|                                                                    |            |
                                           | 2| 5|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    25                                     | 0| 1|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
      Cerebellum, Neuron, Necrosis         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +                                                                     |  51        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +                                                                     |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Bacterium                            |                                                                          |      1  2.0|
      Edema                                |                                                                          |      3  1.3|
      Foreign Body                         | 1  2                                                                     |     26  1.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Inflammation, Acute                  |                                                                          |      3  2.7|
      Inflammation, Chronic Active         | 1  2                                                                     |     40  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
      Foreign Body                         |                                                                          |      3  1.7|
      Fungus                               |                                                                          |      2  3.0|
      Inflammation, Acute                  |                                                                          |     14  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |  52        |
      Abscess                              |                                                                          |      1  4.0|
      Erosion                              |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Perforation                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  17        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Lens, Cataract                       |                                                                          |     16  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |  52        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7|                                                                    |            |
                             DAY ON TEST   | 9| 2|                                                                    |            |
                                           | 2| 5|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    25                                     | 0| 1|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          | 1  2                                                                     |     49  1.8|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |  52        |
      Calculus Gross Observation           |                                                                          |      2     |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|             
                                           | 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/KG                                  | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
      Dilatation                           |                                                    1                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X        X           X     X  X  X           X               |             
      Clear Cell Focus                     | X  X        X     X     X     X  X     X        X        X  X     X     X|             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Focal                  |    1     1  1  2              1  1           1           1               |             
      Hepatodiaphragmatic Nodule           |                   X           X                                          |             
      Hyperplasia                          |                         2                                                |             
      Mixed Cell Focus                     |                                     X  X                 X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                               2                                          |             
      Acinus, Atrophy                      | 2           2  1  1  1     2     2     2  1  2        1           3      |             
      Acinus, Hyperplasia                  |                      2                                                   |             
      Artery, Inflammation, Chronic Active |                                  3                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |             1     1     1     1        1                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                2                                                         |             
      Hyperplasia, Diffuse, Squamous       |                                                    2                     |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Hyperplasia                          |          1                                                               |             
      Inflammation, Chronic                |                                                          1               |             
      Ulcer                                |                3                                                     2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     2  2  3  3  2  2  2  3  2  2  3     2  1  2  2  1  1  1  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|             
                                           | 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/KG                                  | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |          2     1        2     2  3           2              1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |             X     X     X     X        X                                 |             
      Pars Distalis, Hemorrhage            |                                                             3            |             
      Pars Distalis, Hyperplasia           | 3              2  2  1        2           2     2                 2     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Congestion                           |                                                                          |             
      C-Cell, Hyperplasia                  | 1        1                 2     1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2                                                               |             
      Interstitial Cell, Hyperplasia       |                3     2     1        2  2        2     2           2     2|             
      Seminiferous Tubule, Atrophy         |                            2     3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |       2                                                                  |             
      Pigmentation                         |                                                                2         |             
      Capsule, Necrosis                    |                                                                      4   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|             
                                           | 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/KG                                  | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  M  +  +  M  +  M  +  M  +  +  M  +  +  +  M  +  +  +  +  M  +|             
      Fibrosis                             |                                                          2               |             
      Galactocele                          |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Inflammation, Chronic Active         |                                                                         1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   1                                                  2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       1                                                                  |             
      Gliosis, Focal                       |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |          2                                                               |             
      Cerebellum, Neuron, Necrosis         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3                                                                  |             
      Edema                                |                            2                                             |             
      Fibrosis                             |                                                                          |             
      Foreign Body                         |       1  1        2                 2        1           1               |             
      Granuloma                            |          2                                                               |             
      Hemorrhage                           |                2                    2     2           3                  |             
      Infiltration Cellular, Histiocyte    |                            2                                1        1   |             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic Active         | 2  2        1     2  2  2  2  2  2     2     1  2        1        2      |             
      Alveolar Epithelium, Hyperplasia     |             1                                                            |             
      Mediastinum, Bacterium               |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    1                                   1                                 |             
      Fungus                               |                1     2                 2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|             
                                           | 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    MG/KG                                  | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  | 1  2     1     3     2                 2     1  1  2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +     +  +     +  +  +     +  +           +           +  +     +      |             
      Lens, Cataract                       | 2  2     3  2     2  2  2     2  2           2           2  2     2      |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |             2                                                            |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2  2     3  2  3  2  2  3  2  3  2  1  2  1  2  2  2  1  2  2     2  2  2|             
      Cortex, Mineralization               |          1                                                               |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                X         |             
      Hyperplasia                          |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|             
                                           | 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X  X     X        X           X     X        X     X        X     X|             
      Clear Cell Focus                     | X  X     X     X     X  X        X  X  X           X           X  X  X  X|             
      Cyst                                 |                                                          X               |             
      Eosinophilic Focus                   |          X                       X     X                    X           X|             
      Fatty Change, Focal                  |    1           1                 1                 2                     |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                            +            |             
      Artery, Inflammation, Chronic Active |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                                                          |             
      Acinus, Atrophy                      | 1        2     1  3  2        1        2     1  1  2  1        1  2     1|             
      Acinus, Hyperplasia                  |                                  2                                2      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Metaplasia, Squamous           |       1                                            1                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Hyperplasia, Diffuse, Squamous       |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             1              1                 2        2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  2  2  2  3  2     1  1  2  2  2  3  2  1  2  2  2  1     2  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|             
                                           | 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |    1                             2                 1  1  1  2           1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   1                                                      |             
      Pars Distalis, Cyst                  |                            X           X                          X  X   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  2  1  2  2           1     2     2        1     3           2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               1                                          |             
      C-Cell, Hyperplasia                  |                                  1                          2  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2                                                                        |             
      Hyperplasia                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                          4               |             
      Concretion                           |                               1                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          1               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Interstitial Cell, Hyperplasia       | 1  2     2  1     1     2        2           1  1        1  2  2        2|             
      Seminiferous Tubule, Atrophy         |                   3                                3     3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               1                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Congestion                           |                                                                          |             
      Pigmentation                         |                               2                                          |             
      Capsule, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|             
                                           | 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  M  M  +  +  M  +  +  +  +  +  +  +  M  +  M|             
      Fibrosis                             |                                                    2                     |             
      Galactocele                          | X                                                                        |             
      Hemorrhage                           |                                                    2                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Gliosis, Focal                       |                                              1                           |             
      Hemorrhage                           |                      2                                                   |             
      Mineralization                       |                                                                          |             
      Cerebellum, Neuron, Necrosis         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                         2|             
      Foreign Body                         |          1                 1  1  1        1              1     2  1      |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                               3                 3                        |             
      Infiltration Cellular, Histiocyte    |                                           1              2              1|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |    2  2  2  2  1  1  1  2     1  2  2  1           2  1  2  1  2  2  2  1|             
      Alveolar Epithelium, Hyperplasia     |                3                                                         |             
      Mediastinum, Bacterium               |                                                       2                  |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   2        1                          1                  |             
      Fungus                               | 2                                            2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|             
                                           | 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50                                     | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
    MG/KG                                  | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  | 2                 2                          1        1           1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +        +     +           +              +           +        +|             
      Lens, Cataract                       |    2     3        3                 2              2           2        2|             
      Retina, Atrophy                      |                         1                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hydronephrosis                       |                                              2                           |             
      Nephropathy                          | 2  2  2  2  1  2  2  2  3  2     2  1  2  2  1  1  2  2  2  2  2  2  2  2|             
      Cortex, Mineralization               |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                      X                                                   |             
      Calculus Micro Observation Only      |                      X                                                   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7|                                                                    |            |
                             DAY ON TEST   | 2| 2|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    50                                     | 7| 8|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +                                                                     |  50        |
      Dilatation                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +                                                                     |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +                                                                     |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +                                                                     |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +                                                                     |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +                                                                     |  52        |
      Basophilic Focus                     |    X                                                                     |     22     |
      Clear Cell Focus                     | X  X                                                                     |     29     |
      Cyst                                 |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      5     |
      Fatty Change, Focal                  |    1                                                                     |     13  1.2|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +                                                                     |  52        |
      Metaplasia                           |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 2  1                                                                     |     28  1.6|
      Acinus, Hyperplasia                  |                                                                          |      3  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +                                                                     |  52        |
      Duct, Metaplasia, Squamous           |                                                                          |      7  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +                                                                     |  52        |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Hyperplasia, Diffuse, Squamous       |                                                                          |      1  2.0|
      Hyperplasia, Focal, Squamous         | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +                                                                     |  49        |
      Erosion                              |                                                                          |      4  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +                                                                     |  52        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7|                                                                    |            |
                             DAY ON TEST   | 2| 2|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    50                                     | 7| 8|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cardiomyopathy                       | 2  2                                                                     |     47  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +                                                                     |  52        |
      Hyperplasia                          |    3                                                                     |     15  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +                                                                     |  52        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +                                                                     |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +                                                                     |  52        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Cyst                  |                                                                          |      9     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                                          |     20  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +                                                                     |  50        |
      Congestion                           |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  | 1                                                                        |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                                                                     |  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +                                                                     |  52        |
      Abscess                              |                                                                          |      1  4.0|
      Concretion                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +                                                                     |  52        |
      Atrophy                              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +                                                                     |  52        |
      Inflammation                         |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                                                          |     22  1.7|
      Seminiferous Tubule, Atrophy         |                                                                          |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7|                                                                    |            |
                             DAY ON TEST   | 2| 2|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    50                                     | 7| 8|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +                                                                     |  52        |
      Congestion                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +                                                                     |  51        |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      2  2.0|
      Capsule, Necrosis                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +                                                                     |  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                                                                     |  38        |
      Fibrosis                             |                                                                          |      2  2.0|
      Galactocele                          |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +                                                                     |  52        |
      Acanthosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +                                                                     |  52        |
      Atrophy                              |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +                                                                     |  52        |
      Congestion                           |                                                                          |      1  1.0|
      Gliosis, Focal                       |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Cerebellum, Neuron, Necrosis         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +                                                                     |  52        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +                                                                     |  50        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +                                                                     |  52        |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05214-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 03/18/94  
Route: GAVAGE                                                                                                     Time: 18:28:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7|                                                                    |            |
                             DAY ON TEST   | 2| 2|                                                                    |            |
                                           | 5| 7|                                                                    |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0|                                                                    |      O     |
   FISCHER 344 RATS MALE                   | 0| 0|                                                                    |      T     |
                               ANIMAL ID   | 2| 2|                                                                    |      A     |
    50                                     | 7| 8|                                                                    |      L     |
    MG/KG                                  | 9| 0|                                                                    |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Foreign Body                         | 2                                                                        |     15  1.3|
      Granuloma                            |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      6  2.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      6  1.3|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2  2                                                                     |     36  1.7|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
      Mediastinum, Bacterium               |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +                                                                     |  52        |
      Foreign Body                         |                                                                          |      5  1.2|
      Fungus                               |                                                                          |      5  1.8|
      Inflammation, Acute                  |                                                                          |     14  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +                                                                     |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |  21        |
      Lens, Cataract                       |                                                                          |     20  2.2|
      Retina, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +                                                                     |  52        |
      Degeneration                         |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  2                                                                     |     49  2.0|
      Cortex, Mineralization               |                                                                          |      1  1.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +                                                                     |  52        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
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