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TDMS Study 05217-04 Pathology Tables

NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 08:12:00




       Facility:  Southern Research Institute

       Chemical CAS #:  1948330

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                39           32                                                               
    Natural Death                                      3            4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           24                                                               

  Animals Examined Microscopically                    70           70                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (68)         (69)                                                             
      Epithelium, Hyperplasia                          1 (1%)                                                                       
   Intestine Large, Colon                             (69)         (70)                                                             
      Parasite Metazoan                                5 (7%)       6 (9%)                                                          
   Intestine Large, Rectum                            (70)         (70)                                                             
      Parasite Metazoan                                5 (7%)       7 (10%)                                                         
   Intestine Large, Cecum                             (70)         (69)                                                             
      Edema                                            1 (1%)       1 (1%)                                                          
      Parasite Metazoan                                1 (1%)                                                                       
   Intestine Small, Duodenum                          (69)         (69)                                                             
      Erosion                                          1 (1%)                                                                       
      Epithelium, Hyperplasia                          1 (1%)                                                                       
   Liver                                              (70)         (70)                                                             
      Angiectasis                                                   5 (7%)                                                          
      Basophilic Focus                                26 (37%)     23 (33%)                                                         
      Clear Cell Focus                                 2 (3%)       2 (3%)                                                          
      Cyst                                                          1 (1%)                                                          
      Eosinophilic Focus                               7 (10%)     13 (19%)                                                         
      Hematopoietic Cell Proliferation                 2 (3%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (3%)       5 (7%)                                                          
      Inflammation, Granulomatous                      7 (10%)      3 (4%)                                                          
      Inflammation, Subacute                           1 (1%)                                                                       
      Mixed Cell Focus                                 8 (11%)      1 (1%)                                                          
      Necrosis, Focal                                  7 (10%)      2 (3%)                                                          
      Bile Duct, Hyperplasia                          23 (33%)     24 (34%)                                                         
      Centrilobular, Necrosis                                       1 (1%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            7 (10%)      9 (13%)                                                         
      Kupffer Cell, Pigmentation                      14 (20%)     19 (27%)                                                         
   Mesentery                                          (8)          (6)                                                              
      Accessory Spleen                                 2 (25%)                                                                      
      Fat, Necrosis                                    5 (63%)      5 (83%)                                                         
   Pancreas                                           (70)         (69)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                         15 (21%)     11 (16%)                                                         
      Acinus, Cytoplasmic Alteration                   1 (1%)       1 (1%)                                                          
   Stomach, Forestomach                               (69)         (69)                                                             
      Edema                                            1 (1%)       1 (1%)                                                          
      Erosion                                          1 (1%)       2 (3%)                                                          
      Ulcer                                            4 (6%)                                                                       
      Epithelium, Hyperplasia                          5 (7%)       5 (7%)                                                          
   Stomach, Glandular                                 (69)         (70)                                                             
      Edema                                            1 (1%)                                                                       
      Erosion                                          1 (1%)       2 (3%)                                                          
      Mineralization                                   1 (1%)                                                                       
      Ulcer                                            2 (3%)                                                                       
   Tongue                                                          (3)                                                              
      Epithelium, Hyperplasia                                       1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (70)                                                             
      Cardiomyopathy                                  30 (43%)     30 (43%)                                                         
      Mineralization                                   1 (1%)                                                                       
      Thrombosis                                       2 (3%)       2 (3%)                                                          
      Endocardium, Hyperplasia                                      1 (1%)                                                          
      Schwann Cell, Hyperplasia                        1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)                                                             
      Accessory Adrenal Cortical Nodule               10 (14%)     10 (14%)                                                         
      Atrophy                                                       2 (3%)                                                          
      Degeneration, Fatty                             11 (16%)     10 (14%)                                                         
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia, Diffuse                             1 (1%)                                                                       
      Hyperplasia, Focal                               7 (10%)      1 (1%)                                                          
      Hypertrophy, Focal                               5 (7%)       8 (11%)                                                         
      Necrosis                                         1 (1%)                                                                       
   Adrenal Medulla                                    (67)         (70)                                                             
      Hyperplasia                                      5 (7%)      15 (21%)                                                         
   Islets, Pancreatic                                 (70)         (69)                                                             
      Hyperplasia                                                   1 (1%)                                                          
   Parathyroid Gland                                  (62)         (64)                                                             
      Hyperplasia                                      2 (3%)                                                                       
   Pituitary Gland                                    (69)         (70)                                                             
      Pars Distalis, Angiectasis                       2 (3%)      10 (14%)                                                         
      Pars Distalis, Cyst                              9 (13%)     11 (16%)                                                         
      Pars Distalis, Hyperplasia, Focal               11 (16%)     13 (19%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Angiectasis                     2 (3%)       4 (6%)                                                          
      Pars Intermedia, Cyst                            4 (6%)       6 (9%)                                                          
   Thyroid Gland                                      (70)         (69)                                                             
      Ectopic Thymus                                                1 (1%)                                                          
      Ultimobranchial Cyst                             2 (3%)       4 (6%)                                                          
      C-Cell, Hyperplasia                              4 (6%)       3 (4%)                                                          
      Follicle, Cyst                                   1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (69)         (69)                                                             
      Cyst                                             5 (7%)       6 (9%)                                                          
      Hyperplasia                                      5 (7%)       6 (9%)                                                          
      Inflammation, Chronic                            3 (4%)       2 (3%)                                                          
      Inflammation, Suppurative                        2 (3%)                                                                       
   Ovary                                              (70)         (70)                                                             
      Angiectasis                                      2 (3%)                                                                       
      Cyst                                             6 (9%)      14 (20%)                                                         
   Uterus                                             (70)         (70)                                                             
      Hydrometra                                       5 (7%)       3 (4%)                                                          
      Hyperplasia, Cystic                              1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)                                                             
      Hyperplasia                                      1 (1%)                                                                       
      Infiltration Cellular, Histiocyte                             1 (1%)                                                          
      Inflammation, Granulomatous                      1 (1%)       1 (1%)                                                          
      Myelofibrosis                                    1 (1%)       5 (7%)                                                          
      Stromal Cell, Hyperplasia                                     1 (1%)                                                          
   Lymph Node                                         (19)         (23)                                                             
      Iliac, Ectasia                                   1 (5%)                                                                       
      Iliac, Hemorrhage                                             1 (4%)                                                          
      Iliac, Pigmentation                                           1 (4%)                                                          
      Mediastinal, Hemorrhage                                       3 (13%)                                                         
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)                                                          
      Mediastinal, Pigmentation                        8 (42%)     11 (48%)                                                         
      Pancreatic, Ectasia                              1 (5%)                                                                       
      Pancreatic, Pigmentation                         2 (11%)      4 (17%)                                                         
      Renal, Pigmentation                              6 (32%)      5 (22%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                             (70)         (69)                                                             
      Ectasia                                          3 (4%)       2 (3%)                                                          
      Hemorrhage                                       5 (7%)       5 (7%)                                                          
      Hyperplasia, Lymphoid                            9 (13%)      3 (4%)                                                          
      Hyperplasia, Plasma Cell                         1 (1%)       1 (1%)                                                          
      Pigmentation                                    22 (31%)     22 (32%)                                                         
   Lymph Node, Mesenteric                             (69)         (69)                                                             
      Ectasia                                          1 (1%)       2 (3%)                                                          
      Hemorrhage                                       2 (3%)       6 (9%)                                                          
      Hyperplasia, Lymphoid                            1 (1%)                                                                       
      Pigmentation                                                  1 (1%)                                                          
   Spleen                                             (70)         (70)                                                             
      Fibrosis                                         4 (6%)       2 (3%)                                                          
      Hematopoietic Cell Proliferation                 9 (13%)     12 (17%)                                                         
      Hyperplasia, Lymphoid                                         1 (1%)                                                          
      Necrosis                                         1 (1%)       1 (1%)                                                          
      Pigmentation, Hemosiderin                       30 (43%)     38 (54%)                                                         
      Lymphoid Follicle, Atrophy                                    2 (3%)                                                          
      Red Pulp, Atrophy                                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (70)         (69)                                                             
      Dilatation                                      51 (73%)     34 (49%)                                                         
      Galactocele                                      1 (1%)       4 (6%)                                                          
      Hyperplasia                                      3 (4%)       2 (3%)                                                          
   Skin                                               (70)         (70)                                                             
      Inflammation, Chronic                                         2 (3%)                                                          
      Ulcer                                            1 (1%)       2 (3%)                                                          
      Epidermis, Hyperplasia                           1 (1%)       3 (4%)                                                          
      Subcutaneous Tissue, Edema                       1 (1%)       3 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (70)                                                             
      Fibrous Osteodystrophy                           2 (3%)                                                                       
      Cranium, Osteopetrosis                           3 (4%)       2 (3%)                                                          
      Femur, Osteopetrosis                             3 (4%)       7 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)                                                             
      Atrophy                                         17 (24%)     15 (21%)                                                         
      Gliosis                                                       1 (1%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Hydrocephalus                                    1 (1%)       3 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)                                                             
      Edema                                            1 (1%)       3 (4%)                                                          
      Fibrosis                                                      1 (1%)                                                          
      Foreign Body                                     1 (1%)                                                                       
      Hemorrhage                                       2 (3%)       3 (4%)                                                          
      Infiltration Cellular, Histiocyte               33 (47%)     30 (43%)                                                         
      Inflammation, Subacute                           1 (1%)                                                                       
      Mineralization                                   1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (4%)       4 (6%)                                                          
   Nose                                               (70)         (70)                                                             
      Foreign Body                                     1 (1%)       1 (1%)                                                          
      Inflammation, Suppurative                        3 (4%)       2 (3%)                                                          
      Goblet Cell, Hyperplasia                         7 (10%)     13 (19%)                                                         
      Mucosa, Hyperplasia                              4 (6%)       3 (4%)                                                          
      Mucosa, Metaplasia, Squamous                     1 (1%)       1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Inflammation, Chronic                            1 (50%)                                                                      
   Eye                                                             (1)                                                              
      Cataract                                                      1 (100%)                                                        
      Retina, Degeneration                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)                                                             
      Glomerulosclerosis                               1 (1%)                                                                       
      Hydronephrosis                                                2 (3%)                                                          
      Inflammation, Chronic                                         2 (3%)                                                          
      Inflammation, Suppurative                                     1 (1%)                                                          
      Mineralization                                  69 (99%)     66 (94%)                                                         
      Nephropathy                                     38 (54%)     41 (59%)                                                         
      Renal Tubule, Atrophy                            1 (1%)      14 (20%)                                                         
      Renal Tubule, Cytoplasmic Alteration             5 (7%)       1 (1%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         2 (3%)       7 (10%)                                                         
      Renal Tubule, Necrosis                           1 (1%)                                                                       
      Renal Tubule, Pigmentation                      17 (24%)     17 (24%)                                                         
      Transitional Epithelium, Hyperplasia             5 (7%)       5 (7%)                                                          
   Urinary Bladder                                    (70)         (70)                                                             
      Transitional Epithelium, Hyperplasia             1 (1%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      7            5                                                               
    Moribund Sacrifice                                43           33                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           22                                                               

  Animals Examined Microscopically                    70           70                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (70)                                                             
      Parasite Metazoan                                7 (10%)      8 (11%)                                                         
   Intestine Large, Rectum                            (69)         (70)                                                             
      Erosion                                                       1 (1%)                                                          
      Parasite Metazoan                                4 (6%)       7 (10%)                                                         
   Intestine Large, Cecum                             (70)         (70)                                                             
      Edema                                            3 (4%)       2 (3%)                                                          
      Parasite Metazoan                                             3 (4%)                                                          
   Intestine Small, Duodenum                          (70)         (70)                                                             
      Ulcer                                            3 (4%)                                                                       
   Liver                                              (70)         (70)                                                             
      Angiectasis                                      5 (7%)       6 (9%)                                                          
      Basophilic Focus                                 5 (7%)       1 (1%)                                                          
      Clear Cell Focus                                              3 (4%)                                                          
      Cyst                                                          1 (1%)                                                          
      Degeneration, Cystic                             6 (9%)      12 (17%)                                                         
      Eosinophilic Focus                               6 (9%)       9 (13%)                                                         
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (3%)       5 (7%)                                                          
      Inflammation, Subacute                                        1 (1%)                                                          
      Mixed Cell Focus                                              3 (4%)                                                          
      Necrosis, Focal                                  7 (10%)      6 (9%)                                                          
      Thrombosis                                                    2 (3%)                                                          
      Bile Duct, Hyperplasia                          45 (64%)     30 (43%)                                                         
      Centrilobular, Necrosis                                       2 (3%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            2 (3%)       2 (3%)                                                          
      Kupffer Cell, Hyperplasia                        1 (1%)                                                                       
      Kupffer Cell, Pigmentation                      19 (27%)     14 (20%)                                                         
   Mesentery                                          (8)          (5)                                                              
      Accessory Spleen                                 2 (25%)      1 (20%)                                                         
      Fat, Necrosis                                    4 (50%)      1 (20%)                                                         
   Pancreas                                           (68)         (70)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                         21 (31%)     19 (27%)                                                         
      Acinus, Cytoplasmic Alteration                                1 (1%)                                                          
   Salivary Glands                                    (70)         (70)                                                             
      Atrophy                                          1 (1%)       1 (1%)                                                          
   Stomach, Forestomach                               (70)         (70)                                                             
      Erosion                                                       2 (3%)                                                          
      Hyperplasia                                      5 (7%)       3 (4%)                                                          
      Ulcer                                            1 (1%)       1 (1%)                                                          
   Stomach, Glandular                                 (70)         (70)                                                             
      Edema                                            1 (1%)       1 (1%)                                                          
      Erosion                                          1 (1%)       2 (3%)                                                          
      Mineralization                                                1 (1%)                                                          
      Ulcer                                            1 (1%)                                                                       
   Tongue                                             (1)          (2)                                                              
      Epithelium, Hyperplasia                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (69)         (70)                                                             
      Hypertrophy                                      1 (1%)       1 (1%)                                                          
      Inflammation, Subacute                           1 (1%)       1 (1%)                                                          
      Thrombosis                                       1 (1%)                                                                       
   Heart                                              (70)         (70)                                                             
      Cardiomyopathy                                  37 (53%)     45 (64%)                                                         
      Thrombosis                                       5 (7%)       6 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)                                                             
      Accessory Adrenal Cortical Nodule               15 (21%)      7 (10%)                                                         
      Angiectasis                                      1 (1%)       1 (1%)                                                          
      Degeneration, Fatty                             13 (19%)      5 (7%)                                                          
      Hematopoietic Cell Proliferation                              1 (1%)                                                          
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia, Diffuse                             1 (1%)                                                                       
      Hyperplasia, Focal                               2 (3%)       2 (3%)                                                          
      Hypertrophy, Focal                               5 (7%)       5 (7%)                                                          
      Necrosis                                                      1 (1%)                                                          
   Adrenal Medulla                                    (69)         (70)                                                             
      Hyperplasia                                     18 (26%)     15 (21%)                                                         
   Islets, Pancreatic                                 (68)         (70)                                                             
      Hyperplasia                                      2 (3%)       1 (1%)                                                          
   Parathyroid Gland                                  (66)         (66)                                                             
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (67)         (66)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                       3 (4%)       3 (5%)                                                          
      Pars Distalis, Cyst                              8 (12%)      8 (12%)                                                         
      Pars Distalis, Hyperplasia, Focal               14 (21%)      7 (11%)                                                         
      Pars Distalis, Hypertrophy                                    1 (2%)                                                          
      Pars Intermedia, Cyst                            3 (4%)       4 (6%)                                                          
   Thyroid Gland                                      (70)         (69)                                                             
      Ultimobranchial Cyst                             2 (3%)       2 (3%)                                                          
      C-Cell, Hyperplasia                              5 (7%)       5 (7%)                                                          
      Follicle, Cyst                                   2 (3%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (70)                                                             
      Atypia Cellular                                 25 (36%)     19 (27%)                                                         
   Preputial Gland                                    (70)         (69)                                                             
      Cyst                                             3 (4%)       1 (1%)                                                          
      Hyperplasia                                      1 (1%)       2 (3%)                                                          
      Inflammation, Chronic                            9 (13%)     13 (19%)                                                         
      Inflammation, Suppurative                        1 (1%)                                                                       
   Prostate                                           (70)         (70)                                                             
      Inflammation, Suppurative                       30 (43%)     23 (33%)                                                         
      Epithelium, Hyperplasia                          3 (4%)       5 (7%)                                                          
   Testes                                             (70)         (70)                                                             
      Atrophy                                          2 (3%)       4 (6%)                                                          
      Interstitial Cell, Hyperplasia                   3 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)                                                             
      Hyperplasia                                      2 (3%)       2 (3%)                                                          
      Myelofibrosis                                    8 (11%)      3 (4%)                                                          
   Lymph Node                                         (36)         (23)                                                             
      Iliac, Hyperplasia, Lymphoid                                  1 (4%)                                                          
      Iliac, Pigmentation                                           2 (9%)                                                          
      Mediastinal, Hemorrhage                          2 (6%)                                                                       
      Mediastinal, Pigmentation                       19 (53%)     11 (48%)                                                         
      Pancreatic, Pigmentation                         8 (22%)      4 (17%)                                                         
      Renal, Hemorrhage                                1 (3%)                                                                       
      Renal, Pigmentation                              7 (19%)      3 (13%)                                                         
   Lymph Node, Mandibular                             (70)         (70)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Ectasia                                          2 (3%)       2 (3%)                                                          
      Hemorrhage                                       1 (1%)       3 (4%)                                                          
      Hyperplasia, Lymphoid                            5 (7%)       4 (6%)                                                          
      Hyperplasia, Plasma Cell                         1 (1%)       2 (3%)                                                          
      Pigmentation                                    13 (19%)     14 (20%)                                                         
   Lymph Node, Mesenteric                             (70)         (70)                                                             
      Ectasia                                          2 (3%)       4 (6%)                                                          
      Hemorrhage                                       2 (3%)                                                                       
      Hyperplasia, Lymphoid                            1 (1%)       2 (3%)                                                          
   Spleen                                             (70)         (70)                                                             
      Fibrosis                                        13 (19%)     16 (23%)                                                         
      Hematopoietic Cell Proliferation                 2 (3%)       7 (10%)                                                         
      Necrosis                                         2 (3%)       2 (3%)                                                          
      Pigmentation, Hemosiderin                        3 (4%)      18 (26%)                                                         
      Lymphoid Follicle, Atrophy                       2 (3%)       1 (1%)                                                          
   Thymus                                             (64)         (67)                                                             
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (68)         (68)                                                             
      Dilatation                                      16 (24%)     14 (21%)                                                         
      Galactocele                                                   1 (1%)                                                          
      Hyperplasia                                      7 (10%)      9 (13%)                                                         
   Skin                                               (70)         (70)                                                             
      Cyst Epithelial Inclusion                                     1 (1%)                                                          
      Hyperkeratosis                                   1 (1%)                                                                       
      Hyperplasia                                      1 (1%)                                                                       
      Subcutaneous Tissue, Edema                                    1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (70)                                                             
      Hyperostosis                                                  1 (1%)                                                          
      Cranium, Osteopetrosis                                        1 (1%)                                                          
      Femur, Osteopetrosis                             2 (3%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)                                                             
      Atrophy                                          3 (4%)       8 (11%)                                                         
      Hemorrhage                                       1 (1%)                                                                       
      Hydrocephalus                                    1 (1%)       2 (3%)                                                          
      Necrosis                                         1 (1%)       1 (1%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)                                                             
      Congestion                                       1 (1%)                                                                       
      Edema                                            3 (4%)                                                                       
      Hemorrhage                                       4 (6%)       6 (9%)                                                          
      Infiltration Cellular, Histiocyte               14 (20%)     21 (30%)                                                         
      Inflammation, Subacute                                        2 (3%)                                                          
      Alveolar Epithelium, Hyperplasia                 6 (9%)       8 (11%)                                                         
   Nose                                               (70)         (70)                                                             
      Foreign Body                                     3 (4%)       2 (3%)                                                          
      Inflammation                                     1 (1%)                                                                       
      Inflammation, Suppurative                        5 (7%)       2 (3%)                                                          
      Goblet Cell, Hyperplasia                         8 (11%)     17 (24%)                                                         
      Mucosa, Hyperplasia                              8 (11%)      2 (3%)                                                          
      Mucosa, Metaplasia, Squamous                     7 (10%)      1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (3)                                                              
      Cataract                                         1 (100%)     3 (100%)                                                        
      Hemorrhage                                                    1 (33%)                                                         
      Retina, Degeneration                             1 (100%)     3 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)                                                             
      Calculus Micro Observation Only                               2 (3%)                                                          
      Cyst                                             2 (3%)                                                                       
      Hydronephrosis                                                1 (1%)                                                          
      Infiltration Cellular, Lipocyte                  1 (1%)                                                                       
      Inflammation, Suppurative                                     3 (4%)                                                          
      Mineralization                                   4 (6%)                                                                       
      Nephropathy                                     53 (76%)     60 (86%)                                                         
      Renal Tubule, Accumulation, Hyaline Droplet      1 (1%)       1 (1%)                                                          
      Renal Tubule, Atrophy                            1 (1%)       4 (6%)                                                          
      Renal Tubule, Dilatation                                      1 (1%)                                                          
      Renal Tubule, Necrosis                           3 (4%)                                                                       
      Renal Tubule, Pigmentation                      17 (24%)     18 (26%)                                                         
      Transitional Epithelium, Hyperplasia             1 (1%)       5 (7%)                                                          
   Urinary Bladder                                    (70)         (70)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05217-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (1%)       1 (1%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
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