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TDMS Study 05217-04 Pathology Tables

NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 08:12:00




       Facility:  Southern Research Institute

       Chemical CAS #:  1948330

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                39           32                                                               
    Natural Death                                      3            4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           24                                                               

  Animals Examined Microscopically                    70           70                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (69)         (69)                                                             
   Intestine Small, Jejunum                           (70)         (69)                                                             
   Intestine Small, Ileum                             (70)         (69)                                                             
   Liver                                              (70)         (70)                                                             
      Hepatocellular Adenoma                           1 (1%)                                                                       
   Mesentery                                          (8)          (6)                                                              
   Pancreas                                           (70)         (69)                                                             
   Salivary Glands                                    (70)         (70)                                                             
      Schwannoma Malignant                                          1 (1%)                                                          
   Stomach, Forestomach                               (69)         (69)                                                             
      Squamous Cell Papilloma                                       2 (3%)                                                          
   Stomach, Glandular                                 (69)         (70)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (70)                                                             
      Schwannoma Benign                                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)                                                             
      Adenoma                                                       1 (1%)                                                          
   Adrenal Medulla                                    (67)         (70)                                                             
      Pheochromocytoma Malignant                                    1 (1%)                                                          
      Pheochromocytoma Benign                          3 (4%)       4 (6%)                                                          
      Pheochromocytoma Benign, Multiple                1 (1%)                                                                       
   Islets, Pancreatic                                 (70)         (69)                                                             
      Adenoma                                          1 (1%)       2 (3%)                                                          
   Pituitary Gland                                    (69)         (70)                                                             

                                                             Page   2                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          30 (43%)     18 (26%)                                                         
   Thyroid Gland                                      (70)         (69)                                                             
      C-Cell, Adenoma                                  3 (4%)       6 (9%)                                                          
      C-Cell, Carcinoma                                             1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (69)         (69)                                                             
      Adenoma                                          3 (4%)      10 (14%)                                                         
      Carcinoma                                        2 (3%)       5 (7%)                                                          
   Ovary                                              (70)         (70)                                                             
      Granulosa Cell Tumor Malignant                   1 (1%)                                                                       
      Granulosa Cell Tumor Benign                      2 (3%)       1 (1%)                                                          
   Uterus                                             (70)         (70)                                                             
      Polyp Stromal                                    8 (11%)      6 (9%)                                                          
      Sarcoma Stromal                                               1 (1%)                                                          
   Vagina                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)                                                             
   Lymph Node                                         (19)         (23)                                                             
   Lymph Node, Mandibular                             (70)         (69)                                                             
   Lymph Node, Mesenteric                             (69)         (69)                                                             
   Spleen                                             (70)         (70)                                                             
   Thymus                                             (67)         (69)                                                             
      Thymoma Benign                                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (70)         (69)                                                             
      Carcinoma                                        1 (1%)                                                                       
      Fibroadenoma                                    22 (31%)     16 (23%)                                                         
      Fibroadenoma, Multiple                           8 (11%)      1 (1%)                                                          
   Skin                                               (70)         (70)                                                             
      Basal Cell Carcinoma                             1 (1%)                                                                       
      Trichoepithelioma                                1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (1%)       1 (1%)                                                          

                                                             Page   3                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)                                                             
      Astrocytoma Malignant                            1 (1%)                                                                       
   Spinal Cord                                        (4)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (3%)       2 (3%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (1%)                                                                       
   Nose                                               (70)         (70)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)                                                             
   Urinary Bladder                                    (70)         (70)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(70)        *(70)                                                             
      Leukemia Mononuclear                            37 (53%)     34 (49%)                                                         
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          57                                                               
     Total Primary Neoplasms                          133         114                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          42                                                               
     Total Benign Neoplasms                            88          71                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              40          41                                                               
     Total Malignant Neoplasms                         45          43                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   5                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70                                                               

  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      7            5                                                               
    Moribund Sacrifice                                43           33                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           22                                                               

  Animals Examined Microscopically                    70           70                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (70)                                                             
   Intestine Large, Cecum                             (70)         (70)                                                             
   Intestine Small, Duodenum                          (70)         (70)                                                             
   Intestine Small, Jejunum                           (70)         (70)                                                             
      Leiomyosarcoma                                   1 (1%)                                                                       
   Intestine Small, Ileum                             (70)         (69)                                                             
   Liver                                              (70)         (70)                                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (1%)                                                                       
   Mesentery                                          (8)          (5)                                                              
      Hemangiosarcoma                                               1 (20%)                                                         
   Oral Mucosa                                                     (2)                                                              
      Carcinoma                                                     1 (50%)                                                         
      Squamous Cell Papilloma                                       1 (50%)                                                         
   Pancreas                                           (68)         (70)                                                             
      Acinus, Leiomyosarcoma, Metastatic, Stomach,                                                                                  
           Forestomach                                              1 (1%)                                                          
   Salivary Glands                                    (70)         (70)                                                             
   Stomach, Forestomach                               (70)         (70)                                                             
      Leiomyosarcoma                                                1 (1%)                                                          
      Squamous Cell Papilloma                                       3 (4%)                                                          
   Stomach, Glandular                                 (70)         (70)                                                             
   Tongue                                             (1)          (2)                                                              
      Squamous Cell Carcinoma                          1 (100%)                                                                     
      Squamous Cell Papilloma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   6                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (69)         (70)                                                             
   Heart                                              (70)         (70)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (70)                                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (1%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (1%)                                                          
   Adrenal Medulla                                    (69)         (70)                                                             
      Pheochromocytoma Malignant                       2 (3%)       2 (3%)                                                          
      Pheochromocytoma Complex                         1 (1%)                                                                       
      Pheochromocytoma Benign                          7 (10%)     11 (16%)                                                         
      Pheochromocytoma Benign, Multiple                5 (7%)       1 (1%)                                                          
   Islets, Pancreatic                                 (68)         (70)                                                             
      Adenoma                                          2 (3%)       5 (7%)                                                          
      Adenoma, Multiple                                             1 (1%)                                                          
   Pituitary Gland                                    (67)         (66)                                                             
      Pars Distalis, Adenoma                          13 (19%)     16 (24%)                                                         
   Thyroid Gland                                      (70)         (69)                                                             
      C-Cell, Adenoma                                  7 (10%)      5 (7%)                                                          
      C-Cell, Adenoma, Multiple                                     1 (1%)                                                          
      C-Cell, Carcinoma                                             5 (7%)                                                          
      Follicular Cell, Carcinoma                       2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (3)          (3)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (70)         (69)                                                             
      Adenoma                                          1 (1%)       1 (1%)                                                          
      Carcinoma                                        1 (1%)       2 (3%)                                                          
   Prostate                                           (70)         (70)                                                             
   Seminal Vesicle                                    (70)         (70)                                                             
   Testes                                             (70)         (70)                                                             
      Bilateral, Interstitial Cell, Adenoma           52 (74%)     56 (80%)                                                         
      Interstitial Cell, Adenoma                       7 (10%)      4 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (70)                                                             
   Lymph Node                                         (36)         (23)                                                             
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                1 (3%)       1 (4%)                                                          
   Lymph Node, Mandibular                             (70)         (70)                                                             
      Carcinoma, Metastatic, Thyroid Gland             1 (1%)                                                                       
   Lymph Node, Mesenteric                             (70)         (70)                                                             
   Spleen                                             (70)         (70)                                                             
   Thymus                                             (64)         (67)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (68)         (68)                                                             
      Carcinoma                                        1 (1%)       1 (1%)                                                          
      Fibroadenoma                                     4 (6%)       6 (9%)                                                          
   Skin                                               (70)         (70)                                                             
      Basal Cell Adenoma                                            1 (1%)                                                          
      Basal Cell Carcinoma                             1 (1%)                                                                       
      Keratoacanthoma                                  1 (1%)       1 (1%)                                                          
      Sebaceous Gland, Adenoma                         1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                     6 (9%)       3 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (1%)                                                          
      Subcutaneous Tissue, Schwannoma Malignant                     1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (70)                                                             
      Osteosarcoma                                                  2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (70)                                                             
      Astrocytoma Malignant                                         1 (1%)                                                          
   Spinal Cord                                        (2)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (70)                                                             
      Alveolar/Bronchiolar Adenoma                     1 (1%)       1 (1%)                                                          
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (1%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (1%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (1%)       1 (1%)                                                          

                                                             Page   8                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Fibrosarcoma, Metastatic, Skin                                1 (1%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                               1 (1%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (1%)                                                          
   Nose                                               (70)         (70)                                                             
      Squamous Cell Carcinoma                                       1 (1%)                                                          
      Vomeronasal Organ, Adenoma                                    1 (1%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (70)                                                             
      Renal Tubule, Adenoma                                         1 (1%)                                                          
      Transitional Epithelium, Carcinoma                            1 (1%)                                                          
   Urinary Bladder                                    (70)         (70)                                                             
      Papilloma                                                     1 (1%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(70)        *(70)                                                             
      Leukemia Mononuclear                            46 (66%)     39 (56%)                                                         
      Mesothelioma Malignant                           3 (4%)       4 (6%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   9                                                               
NTP Experiment-Test: 05217-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:12:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.5%                                                                
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          60                                                               
     Total Primary Neoplasms                          166         187                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 59          60                                                               
     Total Benign Neoplasms                           107         122                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              52          49                                                               
     Total Malignant Neoplasms                         59          65                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           4                                                               
     Total Metastatic Neoplasm                          5           7                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  10                                                               
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