Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/5070

TDMS Study 05217-04 Pathology Tables


                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-04                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 03/25/95
Route: DOSED FEED                                                                                                 Time: 02:47:17


                                                    RESTRICTED 131 WEEK CORE


       Facility:  Southern Research Institute

       Chemical CAS #:  1948330

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    UNTREATDCONTROL
                               Include 002    UNTREATDCONTROL
                               Include 003    0.5%
                               Include 004    0.5%





























                                                             Page   1

NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 8| 9| 8| 5| 9| 6| 6| 8| 8| 7| 9| 9| 7| 8| 8| 7| 9| 8| 8| 9| 8| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 1| 2| 6| 1| 3| 8| 7| 5| 7| 1| 1| 8| 2| 2| 1| 1| 0| 5| 1| 2| 1|             
                                           | 2| 0| 8| 2| 2| 3| 2| 1| 8| 8| 0| 6| 1| 2| 1| 8| 0| 8| 1| 2| 8| 6| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                               X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                 X  X     X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Epithelium, Hyperplasia              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 3        2           1  2  1           1  3  2  2     1  3     2  3     3|             
      Clear Cell Focus                     |                2              3                                          |             
      Eosinophilic Focus                   |                3                          3                              |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Inflammation, Granulomatous          |                            1                    3                        |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |          4                 3        4           4                        |             
      Necrosis, Focal                      |                      1  1                 2        1                     |             
      Bile Duct, Hyperplasia               | 1           2     2                       2              1              1|             
      Hepatocyte, Vacuolization Cytoplasmic|       3                       1  3  3                                    |             
      Kupffer Cell, Pigmentation           |                                        2  2        3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                    +                                +            |             
      Accessory Spleen                     |                            X                                             |             
      Fat, Necrosis                        |       3                                                     2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        3                    1                    1  1        2         |             
      Acinus, Cytoplasmic Alteration       |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                     4                                    |             
      Epithelium, Hyperplasia              |       2                          1  3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Edema                                |                                     3                                    |             
      Erosion                              |                                                                      3   |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                  2  3                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 8| 9| 8| 5| 9| 6| 6| 8| 8| 7| 9| 9| 7| 8| 8| 7| 9| 8| 8| 9| 8| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 1| 2| 6| 1| 3| 8| 7| 5| 7| 1| 1| 8| 2| 2| 1| 1| 0| 5| 1| 2| 1|             
                                           | 2| 0| 8| 2| 2| 3| 2| 1| 8| 8| 0| 6| 1| 2| 1| 8| 0| 8| 1| 2| 8| 6| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        3                       1  1  1  2                    2     2  3|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                    3                     |             
      Schwann Cell, Hyperplasia            |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                   3      |             
      Degeneration, Fatty                  | 1     1                       3     2                    1  4        2   |             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |             4                       2  1                          4      |             
      Hypertrophy, Focal                   | 2                                         2                              |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                     3  3     3                           |             
      Pars Distalis, Hyperplasia, Focal    |                               2  2                                       |             
      Pars Intermedia, Angiectasis         |                               3                                          |             
      Pars Intermedia, Cyst                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                             3            |             
      C-Cell, Hyperplasia                  |                                           1     1                        |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             2        2                                      3            |             
      Inflammation, Chronic                |                      2                                      3            |             
      Inflammation, Suppurative            |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 8| 9| 8| 5| 9| 6| 6| 8| 8| 7| 9| 9| 7| 8| 8| 7| 9| 8| 8| 9| 8| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 1| 2| 6| 1| 3| 8| 7| 5| 7| 1| 1| 8| 2| 2| 1| 1| 0| 5| 1| 2| 1|             
                                           | 2| 0| 8| 2| 2| 3| 2| 1| 8| 8| 0| 6| 1| 2| 1| 8| 0| 8| 1| 2| 8| 6| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                                            2                     |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                           2     2                        |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |    M  M        M        M     M     M                    +           M   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +        +                       +     +              +      |             
      Iliac, Ectasia                       |                                              3                           |             
      Mediastinal, Pigmentation            |       3              2                             4              3      |             
      Pancreatic, Ectasia                  | 3                                                                        |             
      Pancreatic, Pigmentation             |       4     3                                                            |             
      Renal, Pigmentation                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           2                       2      |             
      Hemorrhage                           |                                                          2        1     3|             
      Hyperplasia, Lymphoid                |                                                       2  2               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                   2     2  2        2     2     2     2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                             2  2      |             
      Hematopoietic Cell Proliferation     |                2                       2                 1  2     1      |             
      Necrosis                             |       3                                                                  |             
      Pigmentation, Hemosiderin            |          2                 2        3  3  2     3  3  2  3     2  2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3  2  3  2        1  2  2  2  3  2     2  3  2  3     2  2     2  3  2   |             
      Galactocele                          |                                                             4            |             
      Hyperplasia                          |                                     3              2                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 8| 9| 8| 5| 9| 6| 6| 8| 8| 7| 9| 9| 7| 8| 8| 7| 9| 8| 8| 9| 8| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 1| 2| 6| 1| 3| 8| 7| 5| 7| 1| 1| 8| 2| 2| 1| 1| 0| 5| 1| 2| 1|             
                                           | 2| 0| 8| 2| 2| 3| 2| 1| 8| 8| 0| 6| 1| 2| 1| 8| 0| 8| 1| 2| 8| 6| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                     2                                    |             
      Cranium, Osteopetrosis               |                               3                                   3      |             
      Femur, Osteopetrosis                 |                                           2                       3      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3     3  3     1                 4     3  2  3      |             
      Hemorrhage                           |                                                                      3   |             
      Hydrocephalus                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +           +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         2                                                |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2     2  1              3  1     1  1  2  2     1           1        1  1|             
      Inflammation, Subacute               |             1                                                            |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          1                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                                           2                              |             
      Goblet Cell, Hyperplasia             |                         1  1                                             |             
      Mucosa, Hyperplasia                  |    2                    1                 2                              |             
      Mucosa, Metaplasia, Squamous         |                                           3                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
      Inflammation, Chronic                |                                                                         4|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |                                                                          |             
      Mineralization                       | 2  2  2  2  3  2  2  2  2  2  3  2  3  3  1  3  2  3  1  2  3  2  1  2  2|             
      Nephropathy                          | 1     2  1  1  1     1     1  1  1  4  1  1  1        1  2  3  1  1     2|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 8| 8| 9| 8| 5| 9| 6| 6| 8| 8| 7| 9| 9| 7| 8| 8| 7| 9| 8| 8| 9| 8| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 1| 2| 6| 1| 3| 8| 7| 5| 7| 1| 1| 8| 2| 2| 1| 1| 0| 5| 1| 2| 1|             
                                           | 2| 0| 8| 2| 2| 3| 2| 1| 8| 8| 0| 6| 1| 2| 1| 8| 0| 8| 1| 2| 8| 6| 1| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    UNTREATD                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |    3              2                                                      |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2     3     2  2                 2                                 |             
      Transitional Epithelium, Hyperplasia |                         1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 8| 5| 8| 6| 9| 9| 6| 9| 8| 8| 9| 7| 7| 8| 6| 8| 7| 9| 8| 9| 7| 7| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 3| 4| 1| 1| 2| 1| 6| 8| 1| 3| 8| 6| 9| 3| 2| 1| 7| 1| 5| 3| 1|             
                                           | 2| 1| 7| 5| 7| 1| 2| 1| 6| 3| 2| 0| 2| 1| 6| 6| 8| 7| 5| 3| 0| 2| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                                                               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2           2     4  3           2                       2  3  3        2|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                            3           2                    3  3         |             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Hepatodiaphragmatic Nodule           |       X                                                                  |             
      Inflammation, Granulomatous          |                   1                                2                 2  2|             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |                                  3                 2     2               |             
      Necrosis, Focal                      |                                  1                                      2|             
      Bile Duct, Hyperplasia               | 2  1  3  2        1                 2  2  2     2     1  3  1  1  3      |             
      Hepatocyte, Vacuolization Cytoplasmic|                         4                                                |             
      Kupffer Cell, Pigmentation           | 2        3              1        2     2        3     2           3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +                                   +                 +      |             
      Accessory Spleen                     |                                                 X                        |             
      Fat, Necrosis                        |    3        2                                                     2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1        1     1                    3        1  1           2  3     1|             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Erosion                              |                                                                      2   |             
      Ulcer                                |                         3                                                |             
      Epithelium, Hyperplasia              |                                                                      1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Mineralization                       |                               4                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 8| 5| 8| 6| 9| 9| 6| 9| 8| 8| 9| 7| 7| 8| 6| 8| 7| 9| 8| 9| 7| 7| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 3| 4| 1| 1| 2| 1| 6| 8| 1| 3| 8| 6| 9| 3| 2| 1| 7| 1| 5| 3| 1|             
                                           | 2| 1| 7| 5| 7| 1| 2| 1| 6| 3| 2| 0| 2| 1| 6| 6| 8| 7| 5| 3| 0| 2| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  2  2  3  2  2           1  1  1     3     2     1        3     1|             
      Mineralization                       |                               4                                          |             
      Thrombosis                           |                                  3                                       |             
      Schwann Cell, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    4        2        1                    2        1  2                  |             
      Degeneration, Fatty                  |             2                 1     2                                    |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |                               3                                          |             
      Hyperplasia, Focal                   |       2                                      3                           |             
      Hypertrophy, Focal                   |       3                             3                                    |             
      Necrosis                             |                                                                   1      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                   3  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            2                       3                     |             
      Pars Distalis, Cyst                  |                3                             3  3     3                  |             
      Pars Distalis, Hyperplasia, Focal    |    3           2           1                    3  3                     |             
      Pars Intermedia, Angiectasis         |                                                    3                     |             
      Pars Intermedia, Cyst                |                         3                    3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      3                                                   |             
      C-Cell, Hyperplasia                  |                            1                                      1      |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3                                               3  3                     |             
      Hyperplasia                          |                                           2     2                        |             
      Inflammation, Chronic                |                                  2                                       |             
      Inflammation, Suppurative            |                            2                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 8| 5| 8| 6| 9| 9| 6| 9| 8| 8| 9| 7| 7| 8| 6| 8| 7| 9| 8| 9| 7| 7| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 3| 4| 1| 1| 2| 1| 6| 8| 1| 3| 8| 6| 9| 3| 2| 1| 7| 1| 5| 3| 1|             
                                           | 2| 1| 7| 5| 7| 1| 2| 1| 6| 3| 2| 0| 2| 1| 6| 6| 8| 7| 5| 3| 0| 2| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                3  3                             3  3                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                   3        2                                             |             
      Hyperplasia, Cystic                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Vagina                                  |                M  M           M           M  M  M                 M      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +        +     +     +  +                 +      |             
      Iliac, Ectasia                       |                                                                          |             
      Mediastinal, Pigmentation            |                                  3                                3      |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Pigmentation                  |                         3              2     3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                             2            |             
      Hemorrhage                           |                                                                      3   |             
      Hyperplasia, Lymphoid                |    3     3  2     2  3                             2           2         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         | 3     2  2  2     2  2     2        2              2     2  2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      3                                                   |             
      Hemorrhage                           |                   2                                                      |             
      Hyperplasia, Lymphoid                |          3                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |             2                 1                    2                     |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |    1     2  2     1  3        2  3  1                       3  2     3  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2  2  3  2  2  2  2  2  2     2  3  2  3  2  2  1  1  2  2  2  2  2  2|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     1                                    |             
      Epidermis, Hyperplasia               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 8| 5| 8| 6| 9| 9| 6| 9| 8| 8| 9| 7| 7| 8| 6| 8| 7| 9| 8| 9| 7| 7| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 3| 4| 1| 1| 2| 1| 6| 8| 1| 3| 8| 6| 9| 3| 2| 1| 7| 1| 5| 3| 1|             
                                           | 2| 1| 7| 5| 7| 1| 2| 1| 6| 3| 2| 0| 2| 1| 6| 6| 8| 7| 5| 3| 0| 2| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               3                                          |             
      Cranium, Osteopetrosis               |                                           2                              |             
      Femur, Osteopetrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4           3        2        3  3  4                       2            |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Foreign Body                         |                      X                                                   |             
      Hemorrhage                           |                                              2                           |             
      Infiltration Cellular, Histiocyte    |    2  2     2        2     1  3  2  2        2  1  1     1     1     1  1|             
      Inflammation, Subacute               |                                                                          |             
      Mineralization                       |                               3                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3           3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               X                                          |             
      Inflammation, Suppurative            |                               2        1                                 |             
      Goblet Cell, Hyperplasia             |                            1     1                 1  1                 1|             
      Mucosa, Hyperplasia                  |                               2                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glomerulosclerosis                   |          4                                                               |             
      Mineralization                       | 3  3  3  4  2  3     2  2  2  3  3  2  2  3  2  3  2  3  3  3  3  3  3  3|             
      Nephropathy                          | 1  1     2  2        1        4  2  1     2        1     1  3  1  1     1|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  10                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 9| 8| 5| 8| 6| 9| 9| 6| 9| 8| 8| 9| 7| 7| 8| 6| 8| 7| 9| 8| 9| 7| 7| 9|             
                             DAY ON TEST   | 1| 1| 2| 7| 3| 4| 1| 1| 2| 1| 6| 8| 1| 3| 8| 6| 9| 3| 2| 1| 7| 1| 5| 3| 1|             
                                           | 2| 1| 7| 5| 7| 1| 2| 1| 6| 3| 2| 0| 2| 1| 6| 6| 8| 7| 5| 3| 0| 2| 2| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Atrophy                |                                  3                                       |             
      Renal Tubule, Cytoplasmic Alteration |                                     3                             2      |             
      Renal Tubule, Dilatation             |          2                                2                              |             
      Renal Tubule, Necrosis               |                                                       4                  |             
      Renal Tubule, Pigmentation           | 3                                2  2  3  2           3        2  2      |             
      Transitional Epithelium, Hyperplasia |                               1        1                          2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 7| 7| 9| 5| 8| 6| 5|                                            |            |
                             DAY ON TEST   | 9| 8| 7| 9| 7| 1| 0| 0| 9| 9|                                            |            |
                                           | 2| 0| 7| 3| 7| 2| 4| 8| 1| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    UNTREATD                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Epithelium, Hyperplasia              |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erosion                              |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     | 2  1                 1                                                   |     26  2.2|
      Clear Cell Focus                     |                                                                          |      2  2.5|
      Eosinophilic Focus                   |                3                                                         |      7  2.9|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Granulomatous          |                3                                                         |      7  2.0|
      Inflammation, Subacute               | 2                                                                        |      1  2.0|
      Mixed Cell Focus                     |    3                                                                     |      8  3.1|
      Necrosis, Focal                      |             1                                                            |      7  1.3|
      Bile Duct, Hyperplasia               |       1  3  2                                                            |     23  1.8|
      Hepatocyte, Vacuolization Cytoplasmic|                         2  4                                             |      7  2.9|
      Kupffer Cell, Pigmentation           |             2           2  4                                             |     14  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   8        |
      Accessory Spleen                     |                                                                          |      2     |
      Fat, Necrosis                        |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |     15  1.5|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                | 2  3                                                                     |      4  3.0|
      Epithelium, Hyperplasia              |    4                                                                     |      5  2.2|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  12                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 7| 7| 9| 5| 8| 6| 5|                                            |            |
                             DAY ON TEST   | 9| 8| 7| 9| 7| 1| 0| 0| 9| 9|                                            |            |
                                           | 2| 0| 7| 3| 7| 2| 4| 8| 1| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    UNTREATD                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2     1  3     2           2                                             |     29  1.9|
      Mineralization                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      2  3.0|
      Schwann Cell, Hyperplasia            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                1        1                                                |      9  1.9|
      Degeneration, Fatty                  |       1                                                                  |     11  1.8|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |          1                                                               |      7  2.4|
      Hypertrophy, Focal                   |       1                                                                  |      5  2.2|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  I                                             |  57        |
      Hyperplasia                          |          1  2                                                            |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  55        |
      Hyperplasia                          |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |                3           3                                             |      9  3.0|
      Pars Distalis, Hyperplasia, Focal    |          3  2        1  1                                                |     11  2.1|
      Pars Intermedia, Angiectasis         |                                                                          |      2  3.0|
      Pars Intermedia, Cyst                |          3                                                               |      4  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      2  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      4  1.0|
      Follicle, Cyst                       | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  13                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 7| 7| 9| 5| 8| 6| 5|                                            |            |
                             DAY ON TEST   | 9| 8| 7| 9| 7| 1| 0| 0| 9| 9|                                            |            |
                                           | 2| 0| 7| 3| 7| 2| 4| 8| 1| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    UNTREATD                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                3     3                                                   |      5  3.0|
      Hyperplasia                          |                                                                          |      5  2.2|
      Inflammation, Chronic                |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 |       3                 3                                                |      6  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      4  2.3|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         M  M                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |    2                                                                     |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +           +  +                                             |  19        |
      Iliac, Ectasia                       |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                         3  3                                             |      8  3.0|
      Pancreatic, Ectasia                  |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      2  3.5|
      Renal, Pigmentation                  |          3              3                                                |      6  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      3  2.0|
      Hemorrhage                           |                2                                                         |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      9  2.3|
      Hyperplasia, Plasma Cell             |                      3                                                   |      1  3.0|
      Pigmentation                         | 2  3  2                                                                  |     22  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      4  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 7| 7| 9| 5| 8| 6| 5|                                            |            |
                             DAY ON TEST   | 9| 8| 7| 9| 7| 1| 0| 0| 9| 9|                                            |            |
                                           | 2| 0| 7| 3| 7| 2| 4| 8| 1| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    UNTREATD                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |    2                                                                     |      9  1.7|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            | 2  2  2        2     3     3                                             |     30  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |    2  3  2  2  1     2  2  1                                             |     51  2.1|
      Galactocele                          |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  1.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      2  2.5|
      Cranium, Osteopetrosis               |                                                                          |      3  2.7|
      Femur, Osteopetrosis                 |    2                                                                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 3  4                                                                     |     17  2.9|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                   +                                                      |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1     |
      Hemorrhage                           | 3                                                                        |      2  2.5|
      Infiltration Cellular, Histiocyte    | 3        1     2     2     1                                             |     33  1.6|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 7| 7| 9| 5| 8| 6| 5|                                            |            |
                             DAY ON TEST   | 9| 8| 7| 9| 7| 1| 0| 0| 9| 9|                                            |            |
                                           | 2| 0| 7| 3| 7| 2| 4| 8| 1| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    UNTREATD                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Goblet Cell, Hyperplasia             |                                                                          |      7  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      4  1.8|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glomerulosclerosis                   |                                                                          |      1  4.0|
      Mineralization                       | 3  3  3  1  2  2  3  2  2  3                                             |     59  2.4|
      Nephropathy                          | 3  2  2        1                                                         |     38  1.6|
      Renal Tubule, Atrophy                |                                                                          |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration |                         3                                                |      5  2.6|
      Renal Tubule, Dilatation             |                                                                          |      2  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |          2  2                                                            |     17  2.2|
      Transitional Epithelium, Hyperplasia |                         1                                                |      5  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 6| 8| 9| 8| 9| 9| 8| 9| 8| 6| 9| 9| 9| 8| 9| 8| 7| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 5| 9| 4| 7| 6| 1| 9| 1| 1| 5| 1| 0| 4| 1| 1| 0| 3| 1| 3| 8| 1| 1| 1| 1| 4|             
                                           | 2| 6| 1| 2| 6| 2| 7| 1| 1| 5| 2| 2| 9| 1| 2| 9| 7| 2| 7| 8| 1| 1| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                    X                                X  X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X              X  X                                   X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2     2                 3   |             
      Basophilic Focus                     |                2              2     1  2  2  3  1  1        1  1  2  2   |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |    2           3        3     2           3        3     3        2      |             
      Hepatodiaphragmatic Nodule           |                   X           X                                          |             
      Inflammation, Granulomatous          |                      1                                                   |             
      Mixed Cell Focus                     |                                                    3                     |             
      Necrosis, Focal                      |                            2                                             |             
      Bile Duct, Hyperplasia               |       1     1        1           1     1  1     3                 1     2|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|       3     2                    3                                      3|             
      Kupffer Cell, Pigmentation           |       3                    2     3  1                          3        3|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                        |             
      Fat, Necrosis                        |    1                                            2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2           3  1  2  3           1  1                        |             
      Acinus, Cytoplasmic Alteration       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             2                                                            |             
      Erosion                              |                                  1                                       |             
      Epithelium, Hyperplasia              |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                  1                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                    +        +   |             
      Epithelium, Hyperplasia              |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                 2  3     1  2  4  1     3     2  2  2              3|             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 6| 8| 9| 8| 9| 9| 8| 9| 8| 6| 9| 9| 9| 8| 9| 8| 7| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 5| 9| 4| 7| 6| 1| 9| 1| 1| 5| 1| 0| 4| 1| 1| 0| 3| 1| 3| 8| 1| 1| 1| 1| 4|             
                                           | 2| 6| 1| 2| 6| 2| 7| 1| 1| 5| 2| 2| 9| 1| 2| 9| 7| 2| 7| 8| 1| 1| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Endocardium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 2           2              1                          2                 1|             
      Atrophy                              | 3                                                                        |             
      Degeneration, Fatty                  |             2     1           1                       1           2      |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |       3     1                                2                    2     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  1           1        2  1        1     3     3        1  1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3        2  3                    2  2              1                     |             
      Pars Distalis, Cyst                  | 3  3  3           3                    3     3                           |             
      Pars Distalis, Hyperplasia, Focal    |             1     3           2  1     3           1              2      |             
      Pars Intermedia, Angiectasis         |             3                       3                                    |             
      Pars Intermedia, Cyst                |    3                             3     3           3                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                 3                        |             
      C-Cell, Hyperplasia                  |                   1                                            2         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                3  3                              |             
      Hyperplasia                          | 2     3                                         2              2         |             
      Inflammation, Chronic                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3           3                             3  3     3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |       M  M        M              M           M           M               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                         3                                                |             
      Inflammation, Granulomatous          |                                                                          |             
      Myelofibrosis                        |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 6| 8| 9| 8| 9| 9| 8| 9| 8| 6| 9| 9| 9| 8| 9| 8| 7| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 5| 9| 4| 7| 6| 1| 9| 1| 1| 5| 1| 0| 4| 1| 1| 0| 3| 1| 3| 8| 1| 1| 1| 1| 4|             
                                           | 2| 6| 1| 2| 6| 2| 7| 1| 1| 5| 2| 2| 9| 1| 2| 9| 7| 2| 7| 8| 1| 1| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Stromal Cell, Hyperplasia            | 4                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +        +        +        +              +  +        +|             
      Iliac, Hemorrhage                    |                                     3                                    |             
      Iliac, Pigmentation                  |                                                                          |             
      Mediastinal, Hemorrhage              |                                     2        2                           |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     2                                    |             
      Mediastinal, Pigmentation            |                            3        3        3              2  3         |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Pigmentation                  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         2           2                                    |             
      Hemorrhage                           |                                     3        3                           |             
      Hyperplasia, Lymphoid                |                         2           3     2                              |             
      Hyperplasia, Plasma Cell             | 3                                                                        |             
      Pigmentation                         | 2           2  2     2           2     2        2  2  2           2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                             4            |             
      Hemorrhage                           |                                     3        3              3            |             
      Pigmentation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     | 3  2                                      1  2        2                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |    2           3     2  2     2  2  3     2  2     3  1  2     2  2  2   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             2     2     1  2  1  2           2                 2     2   |             
      Galactocele                          |       3                                                           4      |             
      Hyperplasia                          |                      2                                   3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Edema           |                                     4        3                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 | 3        2                                                               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 6| 8| 9| 8| 9| 9| 8| 9| 8| 6| 9| 9| 9| 8| 9| 8| 7| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 5| 9| 4| 7| 6| 1| 9| 1| 1| 5| 1| 0| 4| 1| 1| 0| 3| 1| 3| 8| 1| 1| 1| 1| 4|             
                                           | 2| 6| 1| 2| 6| 2| 7| 1| 1| 5| 2| 2| 9| 1| 2| 9| 7| 2| 7| 8| 1| 1| 2| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  3              4     2                             3  1            |             
      Gliosis                              |                                                       2                  |             
      Hydrocephalus                        |                                                          2               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                               1                                         1|             
      Infiltration Cellular, Histiocyte    |       1  1           1  1     1     1           1  1  1  1     1         |             
      Alveolar Epithelium, Hyperplasia     |       2                       1     1                                   3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |       3                                                                  |             
      Goblet Cell, Hyperplasia             | 2                    3     1        1                                    |             
      Mucosa, Hyperplasia                  |       2  1                                                               |             
      Mucosa, Metaplasia, Squamous         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                                          2               |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2  2  1  2  1  1     2  1  3  2  3  2  2  1  1  2  1  1  1  3  1  2  1  2|             
      Nephropathy                          |       1     2  1  1  3  1  1  2  1     1  1  1  1        3  1     1  1  1|             
      Renal Tubule, Atrophy                |       2           3        2  2        3     3  3                    2   |             
      Renal Tubule, Cytoplasmic Alteration |       2                                                                  |             
      Renal Tubule, Dilatation             |                   2                          2                           |             
      Renal Tubule, Pigmentation           | 2                          2  2        2        1           1  2        3|             
      Transitional Epithelium, Hyperplasia |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 9| 8| 8| 8| 7| 6| 5| 8| 7| 7| 9| 9| 9| 9| 5| 7| 9| 8| 9| 4| 9| 7| 6| 9|             
                             DAY ON TEST   | 0| 1| 5| 8| 4| 7| 7| 9| 5| 8| 1| 1| 1| 1| 1| 4| 4| 1| 2| 1| 9| 1| 6| 8| 1|             
                                           | 0| 1| 6| 5| 1| 3| 3| 3| 6| 0| 2| 2| 1| 1| 2| 0| 1| 1| 3| 2| 9| 1| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X     X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2        2            |             
      Basophilic Focus                     |                         1  2  1     3     1        2     1     2         |             
      Clear Cell Focus                     |                                                    4                     |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                  3     2                                3|             
      Hepatodiaphragmatic Nodule           |          X                                                               |             
      Inflammation, Granulomatous          |                                                    1           1         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               |       3  1     2  2        2                             2     1  2  1  1|             
      Centrilobular, Necrosis              |                                                       2                  |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  2                                4      |             
      Kupffer Cell, Pigmentation           |             2     3        4                 1        3  1        1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +                                                |             
      Fat, Necrosis                        |       4                 4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1                 1                       1                     |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                  2                                       |             
      Epithelium, Hyperplasia              |          1              1        2                 2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       3                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2  2              3  3     2        1        2  1  2     3  2      |             
      Thrombosis                           |          4                                                  3            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 9| 8| 8| 8| 7| 6| 5| 8| 7| 7| 9| 9| 9| 9| 5| 7| 9| 8| 9| 4| 9| 7| 6| 9|             
                             DAY ON TEST   | 0| 1| 5| 8| 4| 7| 7| 9| 5| 8| 1| 1| 1| 1| 1| 4| 4| 1| 2| 1| 9| 1| 6| 8| 1|             
                                           | 0| 1| 6| 5| 1| 3| 3| 3| 6| 0| 2| 2| 1| 1| 2| 0| 1| 1| 3| 2| 9| 1| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Endocardium, Hyperplasia             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      3                          1  1                     |             
      Atrophy                              |                                              3                           |             
      Degeneration, Fatty                  |    2        2                 1        1                       3         |             
      Hyperplasia, Focal                   |    2                                                                     |             
      Hypertrophy, Focal                   |          2                                               3     3         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3  1              1                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                                               2        3      |             
      Pars Distalis, Cyst                  |          3                 3                       3                     |             
      Pars Distalis, Hyperplasia, Focal    |                                              2     2  3           3     4|             
      Pars Intermedia, Angiectasis         |          2              2                                                |             
      Pars Intermedia, Cyst                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                        3                       3         |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          3               |             
      Hyperplasia                          |                                                                   2      |             
      Inflammation, Chronic                |                                                                2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3  3              3        3              3        3                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Granulomatous          |                                                    2                     |             
      Myelofibrosis                        |             2     4     4                    3                           |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 9| 8| 8| 8| 7| 6| 5| 8| 7| 7| 9| 9| 9| 9| 5| 7| 9| 8| 9| 4| 9| 7| 6| 9|             
                             DAY ON TEST   | 0| 1| 5| 8| 4| 7| 7| 9| 5| 8| 1| 1| 1| 1| 1| 4| 4| 1| 2| 1| 9| 1| 6| 8| 1|             
                                           | 0| 1| 6| 5| 1| 3| 3| 3| 6| 0| 2| 2| 1| 1| 2| 0| 1| 1| 3| 2| 9| 1| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Stromal Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +     +                 +     +        +     +     +  +   |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Pigmentation                  |                                        3                                 |             
      Mediastinal, Hemorrhage              |                                        3                                 |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |             3        3                 3                    4            |             
      Pancreatic, Pigmentation             |       3                                      3        3              3   |             
      Renal, Pigmentation                  |                                              3                    3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                               1                          1  3            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |       2                 2     2  2     2        2        2  3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                           2              2  3            |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                                                |             
      Hematopoietic Cell Proliferation     |    1     2                                1     2           2  1         |             
      Hyperplasia, Lymphoid                |                                                    4                     |             
      Necrosis                             |                                                                      4   |             
      Pigmentation, Hemosiderin            |    3     2              2  2  3  2  2  2  2  2  2  3        2           2|             
      Lymphoid Follicle, Atrophy           |          3              3                                                |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2  1     2  3  2     2  2  2  3  2  1        3     2  2     1  2     2|             
      Galactocele                          |                                           4                              |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1                                   2                        |             
      Ulcer                                |       2                                         2                        |             
      Epidermis, Hyperplasia               |       2     2                                   2                        |             
      Subcutaneous Tissue, Edema           |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                     3                    3               |             
      Femur, Osteopetrosis                 |                         2  3                             2               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  23                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 9| 8| 8| 8| 7| 6| 5| 8| 7| 7| 9| 9| 9| 9| 5| 7| 9| 8| 9| 4| 9| 7| 6| 9|             
                             DAY ON TEST   | 0| 1| 5| 8| 4| 7| 7| 9| 5| 8| 1| 1| 1| 1| 1| 4| 4| 1| 2| 1| 9| 1| 6| 8| 1|             
                                           | 0| 1| 6| 5| 1| 3| 3| 3| 6| 0| 2| 2| 1| 1| 2| 0| 1| 1| 3| 2| 9| 1| 8| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.5%                                   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  3     1                 3  4        3     4                        |             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                                  3              2                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3        2                                                  2            |             
      Fibrosis                             |                                              4                           |             
      Hemorrhage                           | 3                                                                        |             
      Infiltration Cellular, Histiocyte    |    2     3        1     1  1     1  2  1  1     1        1     1        1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Hyperplasia             |    1  1                                      1                           |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cataract                             |          3                                                               |             
      Retina, Degeneration                 |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                              2                           |             
      Inflammation, Chronic                |                                           2                              |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2  3  2  3  2  2  2  2  2     1  1     2  2  2  1  2  2  1  3  2  1  3   |             
      Nephropathy                          |    3  2     2     1     1  1     3  1  1  3     1  2  1  1     1  1  2  2|             
      Renal Tubule, Atrophy                |                         2  3              3        3                    3|             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                      2  2                          3                     |             
      Renal Tubule, Pigmentation           |                         2                    2        2                  |             
      Transitional Epithelium, Hyperplasia |                   1                       1                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  24                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 8| 8| 6| 9| 9| 9| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 7| 6| 9| 1| 1| 1| 5| 8|                                            |            |
                                           | 7| 2| 2| 2| 6| 3| 2| 3| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |       X              X                                                   |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      5  2.2|
      Basophilic Focus                     |    1              2  2                                                   |     23  1.7|
      Clear Cell Focus                     |                      1                                                   |      2  2.5|
      Cyst                                 |          3                                                               |      1  3.0|
      Eosinophilic Focus                   |    2                 3                                                   |     13  2.6|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation, Granulomatous          |                                                                          |      3  1.0|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis, Focal                      |             1                                                            |      2  1.5|
      Bile Duct, Hyperplasia               |    1     1        1  1     1                                             |     24  1.4|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|             3           2  3                                             |      9  2.8|
      Kupffer Cell, Pigmentation           | 2           1     1     2  3                                             |     19  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +        +                                                |   6        |
      Fat, Necrosis                        |                         2                                                |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |    1                                                                     |     11  1.5|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      2  1.5|
      Epithelium, Hyperplasia              |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   3        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  25                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 8| 8| 6| 9| 9| 9| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 7| 6| 9| 1| 1| 1| 5| 8|                                            |            |
                                           | 7| 2| 2| 2| 6| 3| 2| 3| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    1  1     2  3  3  2  1                                                |     30  2.1|
      Thrombosis                           |                                                                          |      2  3.5|
      Endocardium, Hyperplasia             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |          1     1                                                         |     10  1.5|
      Atrophy                              |                                                                          |      2  3.0|
      Degeneration, Fatty                  |                                                                          |     10  1.6|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          2                                                               |     15  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M                                             |  57        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                         4                                                |     10  2.4|
      Pars Distalis, Cyst                  |          3        3                                                      |     11  3.0|
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |     13  2.2|
      Pars Intermedia, Angiectasis         |                                                                          |      4  2.5|
      Pars Intermedia, Cyst                |          3                                                               |      6  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      3  3.0|
      C-Cell, Hyperplasia                  |                   2                                                      |      3  1.7|
      Follicle, Cyst                       |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                      3                                                   |      5  3.0|
      Hyperplasia                          |          2                                                               |      6  2.2|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  26                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 8| 8| 6| 9| 9| 9| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 7| 6| 9| 1| 1| 1| 5| 8|                                            |            |
                                           | 7| 2| 2| 2| 6| 3| 2| 3| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                            3                                             |     12  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                3                                                         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                   M                                                      |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      5  3.2|
      Stromal Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +     +     +                                                |  23        |
      Iliac, Hemorrhage                    |                                                                          |      1  3.0|
      Iliac, Pigmentation                  |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      3  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |          3  2                                                            |     11  2.9|
      Pancreatic, Pigmentation             |                                                                          |      5  2.8|
      Renal, Pigmentation                  |          3  3                                                            |      5  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Pigmentation                         | 3              2        2                                                |     22  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              | 3                                                                        |      2  3.5|
      Hemorrhage                           |                                                                          |      6  2.7|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |                      1                                                   |     12  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |                      2                                                   |     30  2.2|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  27                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 8| 8| 6| 9| 9| 9| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 7| 6| 9| 1| 1| 1| 5| 8|                                            |            |
                                           | 7| 2| 2| 2| 6| 3| 2| 3| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |    2  2  3  3     4  2  3  2                                             |     34  2.1|
      Galactocele                          |             4                                                            |      4  3.8|
      Hyperplasia                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      2  2.0|
      Epidermis, Hyperplasia               |                                                                          |      3  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               |                                                                          |      2  3.0|
      Femur, Osteopetrosis                 |       2     2                                                            |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |    3        3                                                            |     15  2.8|
      Gliosis                              |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      3  2.3|
      Fibrosis                             |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      3  1.7|
      Infiltration Cellular, Histiocyte    |    2     1     1  1  1     2                                             |     30  1.2|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                            X                                             |      1     |
      Inflammation, Suppurative            |                            1                                             |      2  2.0|
      Goblet Cell, Hyperplasia             | 1                          1                                             |      9  1.3|
      Mucosa, Hyperplasia                  |                            1                                             |      3  1.3|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  28                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 8| 8| 6| 9| 9| 9| 7| 7|                                            |            |
                             DAY ON TEST   | 0| 1| 7| 6| 9| 1| 1| 1| 5| 8|                                            |            |
                                           | 7| 2| 2| 2| 6| 3| 2| 3| 3| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    0.5%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                   2                                                      |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
      Mineralization                       | 2  2  2  2  2  3  2  1  2  1                                             |     56  1.8|
      Nephropathy                          |    1     1  2  1  2                                                      |     41  1.5|
      Renal Tubule, Atrophy                |                   3                                                      |     14  2.6|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                2  3                                                      |      7  2.3|
      Renal Tubule, Pigmentation           |       2  2  3     3     2  2                                             |     17  2.1|
      Transitional Epithelium, Hyperplasia |                   3     2                                                |      5  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  29                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 5| 8| 8| 6| 7| 7| 8| 9| 6| 6| 8| 6| 7| 8| 6| 7| 7| 7| 6| 6| 9| 7| 5| 7|             
                             DAY ON TEST   | 1| 7| 4| 0| 9| 8| 5| 4| 1| 3| 7| 4| 6| 5| 0| 2| 0| 7| 7| 0| 9| 1| 1| 5| 8|             
                                           | 2| 8| 1| 8| 1| 6| 3| 1| 3| 2| 0| 1| 1| 2| 8| 6| 7| 3| 8| 4| 8| 2| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                             X                    X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                    X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      3                    3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |       2              3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4                       2                                      2         |             
      Basophilic Focus                     |                                                          1  2            |             
      Degeneration, Cystic                 | 3     2                                   3                              |             
      Eosinophilic Focus                   |                                              4                 2         |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Focal                      |                                                 1                        |             
      Bile Duct, Hyperplasia               | 3  3  2  2  3  3  2  2  2     4     3  2  3  3  2     3        1  1  1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  1                 3                     |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |    2  3  3        2  2        3        2     2                          2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +                              |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              | 1                          1     1  3  1                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  2                       1                          2               |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                          3               |             
      Inflammation, Subacute               |                                                          4               |             
      Thrombosis                           |                                                          3               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 5| 8| 8| 6| 7| 7| 8| 9| 6| 6| 8| 6| 7| 8| 6| 7| 7| 7| 6| 6| 9| 7| 5| 7|             
                             DAY ON TEST   | 1| 7| 4| 0| 9| 8| 5| 4| 1| 3| 7| 4| 6| 5| 0| 2| 0| 7| 7| 0| 9| 1| 1| 5| 8|             
                                           | 2| 8| 1| 8| 1| 6| 3| 1| 3| 2| 0| 1| 1| 2| 8| 6| 7| 3| 8| 4| 8| 2| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2              1  1  2     3     2  3  2  2  3     1     2        3|             
      Thrombosis                           | 3     4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 2                                      2  2           2     2           1|             
      Angiectasis                          |                                                                3         |             
      Degeneration, Fatty                  |          1                    1     3              3                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |             1                       3                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3  3     1  2        3                    1           1        3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                      3                 3                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                              2                    4      |             
      Pars Distalis, Cyst                  |             3                                                           3|             
      Pars Distalis, Hyperplasia, Focal    |                         3              2     2        2  3     2        2|             
      Pars Intermedia, Cyst                |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                             +        +   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 3              3     3              3        3  3  3  3  3  3           3|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                                               3|             
      Hyperplasia                          |                   2                                                      |             
      Inflammation, Chronic                |                                  2              2           2            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1           2        1  1  2  2  1  1     2     1     1  1     2  3      |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 5| 8| 8| 6| 7| 7| 8| 9| 6| 6| 8| 6| 7| 8| 6| 7| 7| 7| 6| 6| 9| 7| 5| 7|             
                             DAY ON TEST   | 1| 7| 4| 0| 9| 8| 5| 4| 1| 3| 7| 4| 6| 5| 0| 2| 0| 7| 7| 0| 9| 1| 1| 5| 8|             
                                           | 2| 8| 1| 8| 1| 6| 3| 1| 3| 2| 0| 1| 1| 2| 8| 6| 7| 3| 8| 4| 8| 2| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             3            |             
      Myelofibrosis                        |    3  3           3           2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +  +     +        +  +     +  +  +  +  +           +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                   3        3        3  3     3  2     2  2              3|             
      Pancreatic, Pigmentation             | 3        2  3                                                            |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |             4                       3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         3                                      2         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |                      2        2     2  2              2           2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            3                          3                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3     1  3                             3  3        2                  |             
      Hematopoietic Cell Proliferation     |                                                             3            |             
      Necrosis                             |                      2                                                   |             
      Pigmentation, Hemosiderin            |                         3                                                |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                1  2  3        2  1     1           1  2           2      |             
      Hyperplasia                          | 2                                                              2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 5| 8| 8| 6| 7| 7| 8| 9| 6| 6| 8| 6| 7| 8| 6| 7| 7| 7| 6| 6| 9| 7| 5| 7|             
                             DAY ON TEST   | 1| 7| 4| 0| 9| 8| 5| 4| 1| 3| 7| 4| 6| 5| 0| 2| 0| 7| 7| 0| 9| 1| 1| 5| 8|             
                                           | 2| 8| 1| 8| 1| 6| 3| 1| 3| 2| 0| 1| 1| 2| 8| 6| 7| 3| 8| 4| 8| 2| 4| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                  4                                       |             
      Hemorrhage                           |                                                                   4      |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                      3   |             
      Infiltration Cellular, Histiocyte    | 2              3                          1                          2  1|             
      Alveolar Epithelium, Hyperplasia     | 2                                   3                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                                                    4                     |             
      Inflammation, Suppurative            |                         2                                                |             
      Goblet Cell, Hyperplasia             |                      1     2                                2            |             
      Mucosa, Hyperplasia                  |                         3                          3                     |             
      Mucosa, Metaplasia, Squamous         |                         3                          3                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    3           3         |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Mineralization                       |    1                    2                                   1            |             
      Nephropathy                          | 2     1  1  1  1  1  2  2  1  1  3  2  1  3  1  1  1  1        3     1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Necrosis               |             3                 4                                          |             
      Renal Tubule, Pigmentation           |       2  2     3  1        3              2  3        3     3        2   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 9| 6| 8| 8| 8| 5| 6| 7| 8| 6| 6| 9| 7| 8| 8| 7| 5| 9| 6| 7| 7| 6| 9|             
                             DAY ON TEST   | 5| 2| 1| 7| 9| 4| 0| 9| 8| 4| 9| 9| 0| 1| 8| 2| 0| 3| 9| 1| 1| 1| 5| 4| 1|             
                                           | 4| 6| 2| 4| 8| 1| 2| 3| 8| 5| 2| 1| 3| 2| 6| 2| 8| 2| 0| 2| 2| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                       X  X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3           1               |             
      Basophilic Focus                     |          1                                                              2|             
      Degeneration, Cystic                 |                   4                 2                    2               |             
      Eosinophilic Focus                   |       2                                   3                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |             X                       X                                    |             
      Necrosis, Focal                      |          1  1                       1        3                           |             
      Bile Duct, Hyperplasia               | 3  1  2  2     3  3  2        2  3  3  1  1  2  3  3  2  1  1  3  3  2  1|             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                   3      |             
      Kupffer Cell, Pigmentation           |          4  2     2        2  3     3              3  1           3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +           +              +                           |             
      Accessory Spleen                     |                   X           X                                          |             
      Fat, Necrosis                        |             4                                2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1     2  2  2  2        2           1        1  2  1  2     2     3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
      Ulcer                                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       3                  |             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  34                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 9| 6| 8| 8| 8| 5| 6| 7| 8| 6| 6| 9| 7| 8| 8| 7| 5| 9| 6| 7| 7| 6| 9|             
                             DAY ON TEST   | 5| 2| 1| 7| 9| 4| 0| 9| 8| 4| 9| 9| 0| 1| 8| 2| 0| 3| 9| 1| 1| 1| 5| 4| 1|             
                                           | 4| 6| 2| 4| 8| 1| 2| 3| 8| 5| 2| 1| 3| 2| 6| 2| 8| 2| 0| 2| 2| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2              2  3     2     2  2  1  2        1        2     3|             
      Thrombosis                           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                3                 3           2           2  2     2      |             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty                  |       1                                               1  3              1|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |             1                                                            |             
      Hypertrophy, Focal                   |                3                                         3               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1           3           2           3              3           2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                      2   |             
      Pars Distalis, Cyst                  |                               3           3                    3         |             
      Pars Distalis, Hyperplasia, Focal    | 2     1                                                              2  2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1        3                                3              1|             
      Follicle, Cyst                       | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 3        3        3  3        3     3     3  3     3              3  3   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |             2     2                                               2      |             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1  1     1                       1     1  1  1  3     1     1  3|             
      Epithelium, Hyperplasia              |                   1        3                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 9| 6| 8| 8| 8| 5| 6| 7| 8| 6| 6| 9| 7| 8| 8| 7| 5| 9| 6| 7| 7| 6| 9|             
                             DAY ON TEST   | 5| 2| 1| 7| 9| 4| 0| 9| 8| 4| 9| 9| 0| 1| 8| 2| 0| 3| 9| 1| 1| 1| 5| 4| 1|             
                                           | 4| 6| 2| 4| 8| 1| 2| 3| 8| 5| 2| 1| 3| 2| 6| 2| 8| 2| 0| 2| 2| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
      Myelofibrosis                        |                               2              2                 2     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +     +  +     +     +  +  +        +  +  +  +     +  +     +   |             
      Mediastinal, Hemorrhage              |                         2                                                |             
      Mediastinal, Pigmentation            | 3        3     3        3                    3  3     3                  |             
      Pancreatic, Pigmentation             |          3     3        3     2     3                                    |             
      Renal, Hemorrhage                    |                         3                                                |             
      Renal, Pigmentation                  |          4              4     4                                3     3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                                                               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                      2                              |             
      Hyperplasia, Plasma Cell             |                      2                                                   |             
      Pigmentation                         |                      3  2              2                 2  2           2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2           3        3  1     3                        |             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Necrosis                             |                                                       3                  |             
      Pigmentation, Hemosiderin            |                            3                                             |             
      Lymphoid Follicle, Atrophy           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Dilatation                           |                   2        3                 2        3              1   |             
      Hyperplasia                          |             3                 3                          3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 9| 6| 8| 8| 8| 5| 6| 7| 8| 6| 6| 9| 7| 8| 8| 7| 5| 9| 6| 7| 7| 6| 9|             
                             DAY ON TEST   | 5| 2| 1| 7| 9| 4| 0| 9| 8| 4| 9| 9| 0| 1| 8| 2| 0| 3| 9| 1| 1| 1| 5| 4| 1|             
                                           | 4| 6| 2| 4| 8| 1| 2| 3| 8| 5| 2| 1| 3| 2| 6| 2| 8| 2| 0| 2| 2| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                   4        4                                             |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                   3                                                      |             
      Necrosis                             |                               2                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2                                                                     |             
      Edema                                |    2                                                        2            |             
      Hemorrhage                           |                      2                          2                        |             
      Infiltration Cellular, Histiocyte    |                               1  1  1           1        1     2         |             
      Alveolar Epithelium, Hyperplasia     |                               1  2                                      2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      X                    X                              |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                      2                       2                           |             
      Goblet Cell, Hyperplasia             |                         1                 2                          1   |             
      Mucosa, Hyperplasia                  |             1        3                       3                       1   |             
      Mucosa, Metaplasia, Squamous         |                      2  2                 2                          2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cataract                             | 3                                                                        |             
      Retina, Degeneration                 | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Mineralization                       |                               2                                          |             
      Nephropathy                          | 1     2  2  2  2  3  1  1  3  1  1  1  1  2  1  2  1     2  1  1  2     1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                         2                                                |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Necrosis               |                               3                                          |             
      Renal Tubule, Pigmentation           |                      3           2           3  2              2  1      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 4| 7| 7| 9| 9| 5| 9| 7|                                            |            |
                             DAY ON TEST   | 2| 1| 8| 8| 3| 1| 1| 6| 0| 9|                                            |            |
                                           | 6| 2| 4| 0| 0| 2| 2| 9| 0| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                X                                                         |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |    X                                                                     |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                         2                                                |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      5  2.4|
      Basophilic Focus                     |                   1                                                      |      5  1.4|
      Degeneration, Cystic                 |                                                                          |      6  2.7|
      Eosinophilic Focus                   |             2  3                                                         |      6  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Necrosis, Focal                      |          1              1                                                |      7  1.3|
      Bile Duct, Hyperplasia               | 3        3  3              2                                             |     45  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  2.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  3.0|
      Kupffer Cell, Pigmentation           | 3                                                                        |     19  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +        +  +                                                            |   8        |
      Accessory Spleen                     |                                                                          |      2     |
      Fat, Necrosis                        | 3           3                                                            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 1  2     3                                                               |     21  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      5  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |       2                                                                  |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  38                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 4| 7| 7| 9| 9| 5| 9| 7|                                            |            |
                             DAY ON TEST   | 2| 1| 8| 8| 3| 1| 1| 6| 0| 9|                                            |            |
                                           | 6| 2| 4| 0| 0| 2| 2| 9| 0| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypertrophy                          |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  1     2              2  1                                             |     34  1.9|
      Thrombosis                           | 3                       4                                                |      5  3.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |     13  2.0|
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty                  |    3     2           3  2  1                                             |     13  1.9|
      Hemorrhage                           |                      3                                                   |      1  3.0|
      Hyperplasia, Diffuse                 |                      3                                                   |      1  3.0|
      Hyperplasia, Focal                   |             1                                                            |      2  1.0|
      Hypertrophy, Focal                   |                            1                                             |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |    2              3  4     3                                             |     18  2.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.7|
      Pars Distalis, Cyst                  |                   3     3                                                |      7  3.0|
      Pars Distalis, Hyperplasia, Focal    | 1        1                 1                                             |     14  1.9|
      Pars Intermedia, Cyst                |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                         3                                                |      5  2.2|
      Follicle, Cyst                       |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      | 3                    3  3                                                |     25  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  39                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 4| 7| 7| 9| 9| 5| 9| 7|                                            |            |
                             DAY ON TEST   | 2| 1| 8| 8| 3| 1| 1| 6| 0| 9|                                            |            |
                                           | 6| 2| 4| 0| 0| 2| 2| 9| 0| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      3  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |          4     2        2                                                |      9  2.2|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 1                       2  1                                             |     28  1.4|
      Epithelium, Hyperplasia              |          2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                      3                                                   |      2  3.0|
      Interstitial Cell, Hyperplasia       |                      2                                                   |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                          |      8  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +     +        +                                             |  36        |
      Mediastinal, Hemorrhage              |                   3                                                      |      2  2.5|
      Mediastinal, Pigmentation            | 2           3     3                                                      |     19  2.8|
      Pancreatic, Pigmentation             |                                                                          |      8  2.8|
      Renal, Hemorrhage                    |                                                                          |      1  3.0|
      Renal, Pigmentation                  |                                                                          |      7  3.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  2.5|
      Hemorrhage                           |                   1                                                      |      1  1.0|
      Hyperplasia, Lymphoid                |                   3                                                      |      5  2.6|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Pigmentation                         |                         2                                                |     13  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  3.0|
      Hemorrhage                           |                      3                                                   |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |    3        3                                                            |     13  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      2  2.5|
      Pigmentation, Hemosiderin            |    2                                                                     |      3  2.7|
      Lymphoid Follicle, Atrophy           |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |  54        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  40                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 4| 7| 7| 9| 9| 5| 9| 7|                                            |            |
                             DAY ON TEST   | 2| 1| 8| 8| 3| 1| 1| 6| 0| 9|                                            |            |
                                           | 6| 2| 4| 0| 0| 2| 2| 9| 0| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Dilatation                           |          2                 2                                             |     16  1.9|
      Hyperplasia                          |    2                                                                     |      7  2.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       | 3                                                                        |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Osteopetrosis                 |          3                                                               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |       2                                                                  |      3  2.0|
      Hemorrhage                           |                            2                                             |      4  2.3|
      Infiltration Cellular, Histiocyte    | 1                       2  2                                             |     14  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                      X                                                   |      3     |
      Inflammation                         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |          2           2                                                   |      5  2.0|
      Goblet Cell, Hyperplasia             |                1     2                                                   |      8  1.5|
      Mucosa, Hyperplasia                  |          1           3                                                   |      8  2.3|
      Mucosa, Metaplasia, Squamous         |          2                                                               |      7  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  41                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 9| 4| 7| 7| 9| 9| 5| 9| 7|                                            |            |
                             DAY ON TEST   | 2| 1| 8| 8| 3| 1| 1| 6| 0| 9|                                            |            |
                                           | 6| 2| 4| 0| 0| 2| 2| 9| 0| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  3.0|
      Infiltration Cellular, Lipocyte      |          3                                                               |      1  3.0|
      Mineralization                       |                                                                          |      4  1.5|
      Nephropathy                          | 1  3     2  1  3  2  3  2                                                |     51  1.6|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  2.0|
      Renal Tubule, Atrophy                | 2                                                                        |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      3  3.3|
      Renal Tubule, Pigmentation           |          2                                                               |     17  2.3|
      Transitional Epithelium, Hyperplasia |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |             1                                                            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  42                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 7| 8| 9| 9| 9| 7| 9| 7| 8| 8| 8| 9| 8| 7| 9| 9| 6| 9| 6| 7| 7| 9|             
                             DAY ON TEST   | 2| 6| 5| 9| 9| 1| 1| 1| 3| 1| 3| 5| 3| 1| 1| 4| 9| 1| 1| 7| 1| 0| 7| 4| 1|             
                                           | 0| 6| 9| 6| 5| 2| 1| 1| 0| 1| 2| 5| 7| 7| 2| 5| 6| 1| 2| 7| 2| 0| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X     X                                   X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                              4                           |             
      Parasite Metazoan                    |                                           X                          X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                3         |             
      Cyst                                 |                                                       3                  |             
      Degeneration, Cystic                 | 4                             3              1              1            |             
      Eosinophilic Focus                   |                      3     3  3           2                 3            |             
      Hepatodiaphragmatic Nodule           |                         X           X                                X   |             
      Inflammation, Subacute               |                                                 2                        |             
      Mixed Cell Focus                     |                                                             1            |             
      Necrosis, Focal                      | 4                       2           1                                    |             
      Thrombosis                           |    2                                                                     |             
      Bile Duct, Hyperplasia               | 3  3  3           2  1     2  3              2              1     3      |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                       1                  |             
      Kupffer Cell, Pigmentation           | 2     3        2        3     2              4           2        3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                         +         |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          1  2     3           3  2  1  1  3              2     1  3      |             
      Acinus, Cytoplasmic Alteration       |                                              3                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        1                                 |             
      Hyperplasia                          |       1                                                                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
      Erosion                              |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 7| 8| 9| 9| 9| 7| 9| 7| 8| 8| 8| 9| 8| 7| 9| 9| 6| 9| 6| 7| 7| 9|             
                             DAY ON TEST   | 2| 6| 5| 9| 9| 1| 1| 1| 3| 1| 3| 5| 3| 1| 1| 4| 9| 1| 1| 7| 1| 0| 7| 4| 1|             
                                           | 0| 6| 9| 6| 5| 2| 1| 1| 0| 1| 2| 5| 7| 7| 2| 5| 6| 1| 2| 7| 2| 0| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +                    +                                                |             
      Epithelium, Hyperplasia              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3        3  3  1  3  2  1  2        2  3  1  2  1  2  2     2  2     3  3|             
      Thrombosis                           |                                  2           2     3              4      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                1                    3                    1           1   |             
      Angiectasis                          |                3                                                         |             
      Degeneration, Fatty                  |    3     3                                                               |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hyperplasia, Focal                   |                         1                                                |             
      Hypertrophy, Focal                   |          3                                                               |             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                 1  3  1     3  3        2     3                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |                   2                                                      |             
      Pars Distalis, Cyst                  |                            3                 3                           |             
      Pars Distalis, Hyperplasia, Focal    | 2                 3        1                                             |             
      Pars Distalis, Hypertrophy           |                                                                          |             
      Pars Intermedia, Cyst                |       3                             3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                           1        1                 1   |             
      Follicle, Cyst                       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                      +     +                       +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 7| 8| 9| 9| 9| 7| 9| 7| 8| 8| 8| 9| 8| 7| 9| 9| 6| 9| 6| 7| 7| 9|             
                             DAY ON TEST   | 2| 6| 5| 9| 9| 1| 1| 1| 3| 1| 3| 5| 3| 1| 1| 4| 9| 1| 1| 7| 1| 0| 7| 4| 1|             
                                           | 0| 6| 9| 6| 5| 2| 1| 1| 0| 1| 2| 5| 7| 7| 2| 5| 6| 1| 2| 7| 2| 0| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atypia Cellular                      |    3                 3              3                    3     3         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |          2     2                                                         |             
      Inflammation, Chronic                |                                     3                    2               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          3           1  1           4  2           1           4     2  2|             
      Epithelium, Hyperplasia              |                                  1                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
      Myelofibrosis                        | 2                                2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +                    +     +     +  +           +     +     +         |             
      Iliac, Hyperplasia, Lymphoid         |                                                                4         |             
      Iliac, Pigmentation                  |                                                                          |             
      Mediastinal, Pigmentation            |                         3                          3     3               |             
      Pancreatic, Pigmentation             |                                        3                 3               |             
      Renal, Pigmentation                  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         4                                            2   |             
      Hemorrhage                           |                                                       2              2   |             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Hyperplasia, Plasma Cell             |                2                                                         |             
      Pigmentation                         |          2                    2                                   2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                       3                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2  2  4                          3  2     3      |             
      Hematopoietic Cell Proliferation     |             2                                            2     2         |             
      Necrosis                             | 4                                                                        |             
      Pigmentation, Hemosiderin            |                   2           2        2  2     2                 3  2   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             1                    2     2                             3   |             
      Galactocele                          |                                     2                                    |             
      Hyperplasia                          |    2     2     2                                      2                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 7| 8| 9| 9| 9| 7| 9| 7| 8| 8| 8| 9| 8| 7| 9| 9| 6| 9| 6| 7| 7| 9|             
                             DAY ON TEST   | 2| 6| 5| 9| 9| 1| 1| 1| 3| 1| 3| 5| 3| 1| 1| 4| 9| 1| 1| 7| 1| 0| 7| 4| 1|             
                                           | 0| 6| 9| 6| 5| 2| 1| 1| 0| 1| 2| 5| 7| 7| 2| 5| 6| 1| 2| 7| 2| 0| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |             X                                                            |             
      Subcutaneous Tissue, Edema           |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                   3              4              3   |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Infiltration Cellular, Histiocyte    | 1     2     1  1     1     1                 1  1  2           1  2     3|             
      Inflammation, Subacute               |                                                                         3|             
      Alveolar Epithelium, Hyperplasia     | 3        1                                                              3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               X                                          |             
      Inflammation, Suppurative            |                               1                                          |             
      Goblet Cell, Hyperplasia             |                   1  2     2              2        2     1     1         |             
      Mucosa, Hyperplasia                  |                      2                                                   |             
      Mucosa, Metaplasia, Squamous         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +           +                        |             
      Cataract                             |                                     3           2                        |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                                     4           3                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                     X                                    |             
      Hydronephrosis                       |                                     3                                    |             
      Inflammation, Suppurative            |             1                                               1           2|             
      Nephropathy                          | 2  3  2  1  2  2  1  1  2  3  1  2  2  3  3  3  2  2  3  1  3  1  2  2  3|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 7| 8| 9| 9| 9| 7| 9| 7| 8| 8| 8| 9| 8| 7| 9| 9| 6| 9| 6| 7| 7| 9|             
                             DAY ON TEST   | 2| 6| 5| 9| 9| 1| 1| 1| 3| 1| 3| 5| 3| 1| 1| 4| 9| 1| 1| 7| 1| 0| 7| 4| 1|             
                                           | 0| 6| 9| 6| 5| 2| 1| 1| 0| 1| 2| 5| 7| 7| 2| 5| 6| 1| 2| 7| 2| 0| 8| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Atrophy                |                   2                                                     3|             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |    2           2                    2              3     2               |             
      Transitional Epithelium, Hyperplasia |    1                          1     3                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  47                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 7| 9| 9| 7| 9| 9| 9| 9| 8| 7| 9| 8| 6| 7| 7| 9| 9| 7| 7| 6| 7| 8| 7|             
                             DAY ON TEST   | 1| 9| 3| 1| 1| 9| 1| 1| 1| 1| 0| 4| 0| 2| 7| 4| 1| 1| 1| 3| 5| 8| 3| 4| 9|             
                                           | 2| 0| 0| 1| 1| 6| 2| 1| 1| 2| 7| 3| 2| 8| 1| 3| 2| 2| 1| 1| 4| 3| 2| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X  X     X                 X                 X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Parasite Metazoan                    |          X                 X                                   X        X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      2   |             
      Parasite Metazoan                    |                   X                                                  X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                       2                       3        2  2|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |             2                                                            |             
      Cyst                                 |                                                                          |             
      Degeneration, Cystic                 |                            3              2  3        3              3  3|             
      Eosinophilic Focus                   |             3        1                       4                          3|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mixed Cell Focus                     |                                                          3               |             
      Necrosis, Focal                      |                   2                                                     2|             
      Thrombosis                           |                                                                      2   |             
      Bile Duct, Hyperplasia               |    3  2        4  3     1  3     2  3  2     2  2     3           2  3  4|             
      Centrilobular, Necrosis              |    2                                                                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                        1                                 |             
      Kupffer Cell, Pigmentation           |       2           2              3     2     3                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Accessory Spleen                     |                                                 X                        |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2              2  2  1  1  3                                 |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1                                                                  |             
      Hyperplasia                          |                                                          1  3            |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  48                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 7| 9| 9| 7| 9| 9| 9| 9| 8| 7| 9| 8| 6| 7| 7| 9| 9| 7| 7| 6| 7| 8| 7|             
                             DAY ON TEST   | 1| 9| 3| 1| 1| 9| 1| 1| 1| 1| 0| 4| 0| 2| 7| 4| 1| 1| 1| 3| 5| 8| 3| 4| 9|             
                                           | 2| 0| 0| 1| 1| 6| 2| 1| 1| 2| 7| 3| 2| 8| 1| 3| 2| 2| 1| 1| 4| 3| 2| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  2  3     3  2     2  3     3  1  1     2  3  1           3  2  3|             
      Thrombosis                           |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              1                           |             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty                  |          1                          2                             2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |             1                                                            |             
      Hypertrophy, Focal                   |    3                             2  2                 1                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4                    2     3                    2           1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               2                       3                  |             
      Pars Distalis, Cyst                  | 3        3                 3                 3        3                  |             
      Pars Distalis, Hyperplasia, Focal    | 2     2                                      2                           |             
      Pars Distalis, Hypertrophy           |                                                                          |             
      Pars Intermedia, Cyst                |                            3        3                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                    3                    3|             
      C-Cell, Hyperplasia                  |                2                                   1                     |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  49                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 7| 9| 9| 7| 9| 9| 9| 9| 8| 7| 9| 8| 6| 7| 7| 9| 9| 7| 7| 6| 7| 8| 7|             
                             DAY ON TEST   | 1| 9| 3| 1| 1| 9| 1| 1| 1| 1| 0| 4| 0| 2| 7| 4| 1| 1| 1| 3| 5| 8| 3| 4| 9|             
                                           | 2| 0| 0| 1| 1| 6| 2| 1| 1| 2| 7| 3| 2| 8| 1| 3| 2| 2| 1| 1| 4| 3| 2| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atypia Cellular                      |          3        3     3        3  3  3  3        3           3         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        3                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 2     2     2  2                                   2              2      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2        1  3              2  3     1                    2      |             
      Epithelium, Hyperplasia              |                                  1                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                       3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             3            |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +        +  +        +     +  +           +     +           +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Pigmentation                  |    3                                                  3                  |             
      Mediastinal, Pigmentation            |    3           4           3        3           2     3              4   |             
      Pancreatic, Pigmentation             |                4                                                  3      |             
      Renal, Pigmentation                  |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia, Lymphoid                |                         2                                      3         |             
      Hyperplasia, Plasma Cell             |                                     3                                    |             
      Pigmentation                         |                   2  2              2                    2     2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                                               2                        |             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3  3           3        2     2                                      3|             
      Hematopoietic Cell Proliferation     |                                     3                       1            |             
      Necrosis                             |                                                                      4   |             
      Pigmentation, Hemosiderin            |                      2     2              3                    3         |             
      Lymphoid Follicle, Atrophy           |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   2        2           2                 2     1        1|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                      1  1           3                 2                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  50                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 7| 9| 9| 7| 9| 9| 9| 9| 8| 7| 9| 8| 6| 7| 7| 9| 9| 7| 7| 6| 7| 8| 7|             
                             DAY ON TEST   | 1| 9| 3| 1| 1| 9| 1| 1| 1| 1| 0| 4| 0| 2| 7| 4| 1| 1| 1| 3| 5| 8| 3| 4| 9|             
                                           | 2| 0| 0| 1| 1| 6| 2| 1| 1| 2| 7| 3| 2| 8| 1| 3| 2| 2| 1| 1| 4| 3| 2| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Cranium, Osteopetrosis               |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3  4                 3     3         |             
      Hydrocephalus                        |                                        2                 3               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2  2           3                 1                 1      |             
      Infiltration Cellular, Histiocyte    | 2           1     1  2        3        1        1                    1   |             
      Inflammation, Subacute               |                                           4                              |             
      Alveolar Epithelium, Hyperplasia     | 2              2  1  2                 1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              X                           |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Hyperplasia             |       1        1                                         1               |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                X         |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 3     1  2  2  1  3  3  2  3  3  1  3  4  1  2  1  1  3  2  1  3  1  3  2|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  51                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 7| 9| 9| 7| 9| 9| 9| 9| 8| 7| 9| 8| 6| 7| 7| 9| 9| 7| 7| 6| 7| 8| 7|             
                             DAY ON TEST   | 1| 9| 3| 1| 1| 9| 1| 1| 1| 1| 0| 4| 0| 2| 7| 4| 1| 1| 1| 3| 5| 8| 3| 4| 9|             
                                           | 2| 0| 0| 1| 1| 6| 2| 1| 1| 2| 7| 3| 2| 8| 1| 3| 2| 2| 1| 1| 4| 3| 2| 1| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.5%                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                   3      |             
      Renal Tubule, Atrophy                |                                  2                                      3|             
      Renal Tubule, Dilatation             |                                                                3         |             
      Renal Tubule, Pigmentation           |       3        3  2                          2  1  2              3  3   |             
      Transitional Epithelium, Hyperplasia |                                                                2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  52                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 6| 9| 6| 7| 9| 6| 9| 9| 7|                                            |            |
                             DAY ON TEST   | 1| 4| 1| 9| 5| 1| 3| 1| 1| 3|                                            |            |
                                           | 1| 1| 2| 6| 5| 1| 0| 2| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  4.0|
      Parasite Metazoan                    |                      X                                                   |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |    2                                                                     |      2  2.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                      3                                                   |      6  2.3|
      Basophilic Focus                     |                1                                                         |      1  1.0|
      Clear Cell Focus                     |       4                                                                  |      3  3.0|
      Cyst                                 |                                                                          |      1  3.0|
      Degeneration, Cystic                 | 2                    4                                                   |     12  2.7|
      Eosinophilic Focus                   |                                                                          |      9  2.8|
      Hepatodiaphragmatic Nodule           |                   X  X                                                   |      5     |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                2                                                         |      3  2.0|
      Necrosis, Focal                      |                      1                                                   |      6  2.0|
      Thrombosis                           |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               | 2  3     3           2     2                                             |     30  2.5|
      Centrilobular, Necrosis              |          2                                                               |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      2  1.0|
      Kupffer Cell, Pigmentation           | 4                                                                        |     14  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +                                                      |   5        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |          2           3                                                   |     19  2.0|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  53                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 6| 9| 6| 7| 9| 6| 9| 9| 7|                                            |            |
                             DAY ON TEST   | 1| 4| 1| 9| 5| 1| 3| 1| 1| 3|                                            |            |
                                           | 1| 1| 2| 6| 5| 1| 0| 2| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      3  1.7|
      Ulcer                                |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      2  2.5|
      Mineralization                       |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypertrophy                          |             2                                                            |      1  2.0|
      Inflammation, Subacute               |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 1  2  1  3  3     3  2                                                   |     43  2.2|
      Thrombosis                           |                3                                                         |      6  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                3        1                                                |      7  1.6|
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty                  |                                                                          |      5  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  1.0|
      Hypertrophy, Focal                   |                                                                          |      5  2.2|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          1              3                                                |     15  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M                                             |  57        |
      Hyperplasia                          |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +                                             |  56        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Cyst                  |                                                                          |      7  3.0|
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      7  2.0|
      Pars Distalis, Hypertrophy           |                   2                                                      |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      4  3.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  54                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 6| 9| 6| 7| 9| 6| 9| 9| 7|                                            |            |
                             DAY ON TEST   | 1| 4| 1| 9| 5| 1| 3| 1| 1| 3|                                            |            |
                                           | 1| 1| 2| 6| 5| 1| 0| 2| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      2  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      5  1.2|
      Follicle, Cyst                       |             3                                                            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      |    3        3     3  3     3                                             |     19  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Chronic                | 2     2           2  1     2                                             |     13  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 2     3           2  1  3  1                                             |     22  2.1|
      Epithelium, Hyperplasia              | 2                 2        1                                             |      5  1.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                      3                                                   |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      2  2.5|
      Myelofibrosis                        | 2                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                    +                                                |  23        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Iliac, Pigmentation                  |                                                                          |      2  3.0|
      Mediastinal, Pigmentation            |    3                                                                     |     11  3.1|
      Pancreatic, Pigmentation             |                                                                          |      4  3.3|
      Renal, Pigmentation                  |                         3                                                |      3  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      3  2.0|
      Hyperplasia, Lymphoid                |                   2                                                      |      4  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
      Pigmentation                         |    2  2  2        2                                                      |     14  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  55                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 6| 9| 6| 7| 9| 6| 9| 9| 7|                                            |            |
                             DAY ON TEST   | 1| 4| 1| 9| 5| 1| 3| 1| 1| 3|                                            |            |
                                           | 1| 1| 2| 6| 5| 1| 0| 2| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |                                                                          |      4  2.8|
      Hyperplasia, Lymphoid                |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |          3     2     3  3                                                |     16  2.7|
      Hematopoietic Cell Proliferation     |                2  1                                                      |      7  1.9|
      Necrosis                             |                                                                          |      2  4.0|
      Pigmentation, Hemosiderin            |       2     2     2     3                                                |     15  2.3|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +                                             |  58        |
      Dilatation                           |    2  2              2  3                                                |     14  1.9|
      Galactocele                          |                                                                          |      1  2.0|
      Hyperplasia                          | 3                                                                        |      9  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |             3                                                            |      1  3.0|
      Cranium, Osteopetrosis               | 3                                                                        |      1  3.0|
      Femur, Osteopetrosis                 | 3                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      8  3.1|
      Hydrocephalus                        |                                                                          |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      6  1.8|
      Infiltration Cellular, Histiocyte    |                      2                                                   |     21  1.5|
      Inflammation, Subacute               |                                                                          |      2  3.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      8  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  56                                                               
NTP Experiment-Test: 05217-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/25/95  
Route: DOSED FEED                                                                                                 Time: 02:47:17  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 6| 9| 6| 7| 9| 6| 9| 9| 7|                                            |            |
                             DAY ON TEST   | 1| 4| 1| 9| 5| 1| 3| 1| 1| 3|                                            |            |
                                           | 1| 1| 2| 6| 5| 1| 0| 2| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.5%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |                                                                          |      2     |
      Inflammation, Suppurative            |             1                                                            |      2  1.0|
      Goblet Cell, Hyperplasia             |                         2                                                |     11  1.5|
      Mucosa, Hyperplasia                  |             1                                                            |      2  1.5|
      Mucosa, Metaplasia, Squamous         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   3        |
      Cataract                             |                      3                                                   |      3  2.7|
      Hemorrhage                           |                      3                                                   |      1  3.0|
      Retina, Degeneration                 |                      3                                                   |      3  3.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  1.3|
      Nephropathy                          | 3  1  3  1  3  3  1  3  4  2                                             |     59  2.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
      Renal Tubule, Atrophy                |                                                                          |      4  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           | 2  3  2  2                 3                                             |     18  2.3|
      Transitional Epithelium, Hyperplasia |                         3                                                |      5  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  57                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------