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TDMS Study 05217-05 Pathology Tables

NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 08:56:46




       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  08/04/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                  9            8            9            6                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                11            7            6            6                                     
    Natural Death                                      2           10            5            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           35           40           42                                     
    Natural Death                                      1                                      1                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (58)         (58)         (56)         (60)                                   
   Intestine Large, Cecum                             (60)         (58)         (57)         (59)                                   
   Intestine Small, Duodenum                          (60)         (59)         (57)         (59)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Jejunum                           (60)         (59)         (57)         (59)                                   
   Intestine Small, Ileum                             (60)         (59)         (56)         (59)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         7 (12%)      9 (15%)      7 (12%)      4 (7%)                                
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           8 (13%)     11 (18%)     12 (20%)      4 (7%)                                
      Hepatocellular Adenoma, Multiple                 1 (2%)       9 (15%)      5 (8%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
   Mesentery                                          (10)         (13)         (7)          (9)                                    
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (14%)                                            
      Histiocytic Sarcoma                                                        1 (14%)                                            
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (8%)                                                          
   Pancreas                                           (60)         (60)         (58)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Salivary Glands                                    (60)         (60)         (60)         (58)                                   
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                 2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (58)         (60)                                   

                                                             Page   2                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (59)         (59)         (60)                                   
      Capsule, Hepatocellular Carcinoma,                                                                                            
          Metastatic, Liver                                                      1 (2%)                                             
   Adrenal Medulla                                    (60)         (59)         (60)         (60)                                   
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (57)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (58)         (52)         (55)         (55)                                   
      Pars Distalis, Adenoma                           5 (9%)       5 (10%)      5 (9%)       4 (7%)                                
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (60)         (59)         (59)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       3 (5%)       2 (3%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (2)          (1)                                                 
      Pelvic, Hemangiosarcoma, Multiple                                          1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (59)         (60)                                   
   Ovary                                              (59)         (57)         (56)         (56)                                   
      Cystadenoma                                      2 (3%)       2 (4%)       4 (7%)       2 (4%)                                
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Luteoma                                          1 (2%)                                                                       
      Teratoma NOS                                                                            1 (2%)                                
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
      Endometrium, Adenoma                             1 (2%)                    1 (2%)                                             
      Endometrium, Carcinoma                           1 (2%)                                                                       
      Endometrium, Polyp Stromal                                                 3 (5%)       1 (2%)                                

                                                             Page   3                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (7)          (8)          (12)         (9)                                    
      Iliac, Histiocytic Sarcoma                       1 (14%)                   1 (8%)                                             
      Inguinal, Histiocytic Sarcoma                                 1 (13%)                                                         
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (8%)                                             
      Mediastinal, Histiocytic Sarcoma                                           1 (8%)                                             
      Renal, Histiocytic Sarcoma                       1 (14%)                   1 (8%)                                             
   Lymph Node, Mandibular                             (57)         (60)         (59)         (57)                                   
   Lymph Node, Mesenteric                             (59)         (56)         (58)         (56)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       2 (4%)                                
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Thymus                                             (53)         (59)         (56)         (54)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (59)         (60)         (60)                                   
      Carcinoma                                                                               1 (2%)                                
      Myoepithelioma                                                             1 (2%)                                             
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     2 (3%)       2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (50%)                                            
____________________________________________________________________________________________________________________________________

                                                             Page   4                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     3 (5%)       2 (3%)       4 (7%)       3 (5%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (3%)                    1 (2%)                                             
      Basal Cell Carcinoma, Metastatic, Skin           1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                                          1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)       4 (7%)       2 (3%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
      Mediastinum, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Stomach, Forestomach                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (6)          (1)                                    
      Adenoma                                                                    6 (100%)     1 (100%)                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                              1 (2%)                                                          
   Urinary Bladder                                    (60)         (59)         (59)         (59)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)       2 (3%)       3 (5%)       4 (7%)                                
      Lymphoma Malignant                               3 (5%)       9 (15%)     10 (17%)      8 (13%)                               
      Lymphoma Malignant Mixed                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          42          38          33                                       
     Total Primary Neoplasms                           47          62          73          49                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          26          27          19                                       
     Total Benign Neoplasms                            26          34          44          25                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          23          22          22                                       
     Total Malignant Neoplasms                         21          28          29          23                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           6           3                                       
     Total Metastatic Neoplasm                          2           6          12           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10            9            9                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            1            6            2                                     
    Moribund Sacrifice                                 6            3            7            7                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           46           38           42                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (60)         (60)         (57)         (59)                                   
      Carcinoma                                                     1 (2%)       3 (5%)                                             
   Intestine Small, Ileum                             (59)         (59)         (58)         (58)                                   
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemangiosarcoma, Multiple                        2 (3%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         5 (8%)       9 (15%)      8 (13%)      8 (13%)                               
      Hepatocellular Carcinoma, Multiple               3 (5%)       2 (3%)       4 (7%)       1 (2%)                                
      Hepatocellular Adenoma                          22 (37%)     15 (25%)     18 (30%)     11 (18%)                               
      Hepatocellular Adenoma, Multiple                 7 (12%)      8 (13%)      5 (8%)       3 (5%)                                
      Histiocytic Sarcoma                                                        2 (3%)                                             
   Mesentery                                          (2)          (7)          (15)         (1)                                    
      Histiocytic Sarcoma                                           1 (14%)      2 (13%)                                            
   Pancreas                                           (59)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (59)                                   
      Carcinoid Tumor Benign                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (60)                                   
      Subcapsular, Adenoma                             1 (2%)       4 (7%)       1 (2%)       2 (3%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)       1 (2%)                    2 (3%)                                
   Parathyroid Gland                                  (59)         (56)         (58)         (53)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (55)         (52)         (53)         (57)                                   
      Pars Distalis, Adenoma                           1 (2%)                                                                       
   Thyroid Gland                                      (60)         (60)         (59)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       2 (3%)                                             
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (59)                                   
      Hemangioma                                       1 (2%)                                                                       
   Preputial Gland                                    (60)         (59)         (59)         (59)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Testes                                             (60)         (60)         (60)         (60)                                   
      Interstitial Cell, Adenoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Lymph Node                                         (3)          (3)          (6)          (3)                                    
      Iliac, Histiocytic Sarcoma                                                 2 (33%)                                            
      Inguinal, Histiocytic Sarcoma                                 1 (33%)                                                         
      Mediastinal, Histiocytic Sarcoma                              1 (33%)      1 (17%)                                            
      Pancreatic, Histiocytic Sarcoma                                            1 (17%)                                            
      Renal, Histiocytic Sarcoma                                    1 (33%)      1 (17%)                                            
   Lymph Node, Mandibular                             (58)         (58)         (58)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (58)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  4 (7%)       1 (2%)                                                          

                                                             Page   8                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Thymus                                             (53)         (48)         (52)         (51)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             2 (3%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                       (1)          (1)                                    
      Hemangiosarcoma, Multiple                        1 (50%)                                                                      
      Histiocytic Sarcoma                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                    11 (18%)      9 (16%)     10 (17%)     10 (17%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       2 (3%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       3 (5%)       2 (3%)       4 (7%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      2 (3%)       1 (2%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       1 (2%)       2 (3%)       1 (2%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      External Ear, Histiocytic Sarcoma                                                       1 (100%)                              
   Harderian Gland                                    (3)          (9)          (6)          (3)                                    
      Adenoma                                          2 (67%)      8 (89%)      4 (67%)      3 (100%)                              
      Carcinoma                                                                  2 (33%)                                            
      Bilateral, Adenoma                               1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)       2 (3%)       1 (2%)                                
      Lymphoma Malignant                               4 (7%)       2 (3%)       6 (10%)      4 (7%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05217-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 08:56:46  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          UNTREATD     0.125%       0.25%        0.5%                                      
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          46          45          39                                       
     Total Primary Neoplasms                           79          74          73          59                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          39          34          27                                       
     Total Benign Neoplasms                            51          50          43          35                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              21          23          25          21                                       
     Total Malignant Neoplasms                         28          24          30          24                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           1           2           1                                       
     Total Metastatic Neoplasm                          5           1           2           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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